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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

TIAL1 Gene

protein-coding GIFtS: 54
GCID: GC10M121324

TIA1 cytotoxic granule-associated RNA binding protein-like...

(Previous name: TIA1 cytotoxic granule-associated RNA-binding protein-like...)

Explore 19 diseases affiliated with
TIAL1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
TIA1 Cytotoxic Granule-Associated RNA Binding Protein-Like 1¹ ²		Nucleolysin TIAR²
TIAR¹ ² ⁵		T-Cluster Binding Protein²
TCBP² ⁵		TIA-1-Related Nucleolysin²
TIA1 Cytotoxic Granule-Associated RNA-Binding Protein-Like 1¹		TIA-1-Related Protein³
Aging-Associated Gene 7 Protein²

External Ids:	HGNC: 11804¹	Entrez Gene: 7073²	Ensembl: ENSG00000151923⁷	OMIM: 603413⁵	UniProtKB: Q01085³

Export aliases for TIAL1 gene to outside databases

Previous GC identifers: GC10M120253 GC10M120578 GC10M121466 GC10M120999 GC10M114963

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TIAL1:

The protein encoded by this gene is a member of a family of RNA-binding proteins, has three RNA recognition motifs

(RRMs), and binds adenine and uridine-rich elements in mRNA and pre-mRNAs of a wide range of genes. It regulates

various activities including translational control, splicing and apoptosis. Alternate transcriptional splice variants,

encoding different isoforms, have been characterized. The different isoforms have been show to function differently

with respect to post-transcriptional silencing. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: TIAR_HUMAN, Q01085

Function: RNA-binding protein. Possesses nucleolytic activity against cytotoxic lymphocyte target cells. May be

involved in apoptosis

Gene Wiki entry for TIAL1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000010.10 NC_018921.1 NT_030059.13

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the TIAL1 gene promoter:
GR GR-beta Meis-1b C/EBPalpha CHOP-10 FOXJ2 (long isoform) c-Myb GR-alpha Meis-1a Meis-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): TIAL1 promoter sequence

Search SABiosciences Chromatin IP Primers for TIAL1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TIAL1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q Ensembl cytogenetic band: 10q26.11 HGNC cytogenetic band: 10q

TIAL1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TIAL1 gene location

GeneLoc information about chromosome 10 GeneLoc Exon Structure

GeneLoc location for GC10M121324: view genomic region (about GC identifiers)

Start:	121,332,977 bp from pter	End:	121,356,541 bp from pter
Size:	23,565 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: TIAR_HUMAN, Q01085 (See protein sequence)

Recommended Name: Nucleolysin TIAR

Size: 375 amino acids; 41591 Da

Subcellular location: Cytoplasm (By similarity). Nucleus (By similarity). Cytoplasmic granule. Note=The cytoplasmic

granules are stress granules which are a dense aggregation in the cytosol composed of proteins and RNAs that appear

when the cell is under stress. Co-localizes with NANOS3 in the stress granules (By similarity). Cytoplasmic granules

of cytolytic T-lymphocytes

3 PDB 3D structures from and Proteopedia for TIAL1:

1X4G (3D)

2CQI (3D)

2DH7 (3D)

Secondary accessions: A8K3T0 A8K4L9

Alternative splicing: 2 isoforms: Q01085-1 Q01085-2 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TIAL1: NX_Q01085

Post-translational modifications:

Phosphorylated by MAPK14 following DNA damage, releasing TIAR from GADD45A mRNA¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q01085

TIAL1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001029097.1 NP_003243.1

ENSEMBL proteins:

ENSP00000358089 ENSP00000431009 ENSP00000394902 ENSP00000403573 ENSP00000358082

ENSP00000358088

Human Recombinant Protein Products:

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	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate (see all 2): TIAL1 OriGene Custom Protein Services for TIAL1
	GenScript Custom Purified and Recombinant Proteins Services for TIAL1
	Novus Biologicals TIAL1 Proteins Novus Biologicals TIAL1 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for TIAL1

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	ISS	--
GO:0005737	cytoplasm	ISS	--
GO:0005764	lysosome	TAS	1326761
GO:0010494	cytoplasmic stress granule	ISS	--

TIAL1 for ontologies About GeneDecksing

TIAL1 Antibody Products:

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	Uscn ELISAs and CLIAs for TIAL1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

TIAL1 for domains About GeneDecksing

2 InterPro domains/families:

IPR000504 RRM_dom

IPR012677 Nucleotide-bd_a/b_plait

Graphical View of Domain Structure for InterPro Entry Q01085

ProtoNet protein and cluster: Q01085

1 Blocks protein family: IPB000504 RNA-binding region RNP-1 (RNA recognition motif)

UniProtKB/Swiss-Prot: TIAR_HUMAN, Q01085

Similarity: Contains 3 RRM (RNA recognition motif) domains

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: TIAR_HUMAN, Q01085

Function: RNA-binding protein. Possesses nucleolytic activity against cytotoxic lymphocyte target cells. May be

involved in apoptosis

miRNA Products:		OriGene 3'-UTR Clone (see all 2): TIAL1 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TIAL1
		8/26 QIAGEN miScript miRNA Assays for microRNAs that regulate TIAL1 (see all 26):
		hsa-miR-21* hsa-miR-300 hsa-miR-624 hsa-miR-197 hsa-miR-759 hsa-miR-1297 hsa-miR-890 hsa-miR-511

		SwitchGear 3'UTR luciferase reporter plasmid: TIAL1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TIAL1 (see all 7) OriGene shRNA RFP: TIAL1 OriGene siRNA: TIAL1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TIAL1

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for TIAL1

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TIAL1 (see all 5) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TIAL1 (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): TIAL1 (NM_003252)
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		DNA2.0 Custom Codon Optimized Gene Synthesis Service for TIAL1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TIAL1

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for TIAL1
		Search LifeMap BioReagents cell lines for TIAL1

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TIAL1

Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000166	nucleotide binding	IEA	--
GO:0003676	nucleic acid binding	--	--
GO:0003723	RNA binding	TAS	1326761
GO:0017091	AU-rich element binding	IEA	--

TIAL1 for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for TIAL1:

Increased G1 DNA content

Animal Models:
Mouse knock-out Tial1^tm1Mst for TIAL1
5 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Tial1):

embryogenesis

endocrine/exocrine gland

growth/size

mortality/aging

reproductive system

TIAL1 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Chromatin Regulation / Acetylation

Chromatin Regulation / Acetylation

1.00

Apoptosis and Autophagy

Apoptosis and Autophagy

1.00

Translational Control

Translational Control

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

3 Cell Signaling Technology (CST) Pathways for TIAL1

	Chromatin Regulation / Acetylation
	Apoptosis and Autophagy
	Translational Control

TIAL1 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for TIAL1

STRING Interaction Network Preview (showing 5 interactants - click image to see 12)

5/815 Interacting proteins for TIAL1 (Q01085^{2, 3} ENSP00000358089⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 815)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
SMN1	Q16637²^,³, ENSP00000370083⁴	MINT-7945693 MINT-50604 MINT-50603 MINT-7947479 I2D: score=3 STRING: ENSP00000370083
SMN2	Q16637²^,³, ENSP00000370119⁴	MINT-7945693 MINT-50604 MINT-50603 MINT-7947479 I2D: score=3 STRING: ENSP00000370119
SNRPD3	P62318²^,³, ENSP00000215829⁴	MINT-7945693 MINT-7947479 I2D: score=4 STRING: ENSP00000215829
DDX5	P17844²^,³	MINT-7945693 MINT-7947479 I2D: score=1
EEF1A1	P68104²^,³	MINT-7945693 MINT-7947479 I2D: score=1

About this table

Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006357	regulation of transcription from RNA polymerase II promoter	TAS	9207209
GO:0006915	apoptotic process	IEA	--
GO:0006917	induction of apoptosis	TAS	1326761
GO:0006952	defense response	TAS	1326761
GO:0007281	germ cell development	IEA	--

TIAL1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

TIAL1 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for TIAL1
4 Novoseek chemical compound relationships for TIAL1 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
flupirtine	74	2	9804146 (1), 9191602 (1)
uridine	36.8	1	16890199 (1)
vegf	2.2	3	16091628 (1), 11456315 (1)
atp	0	7	16890199 (1), 17466948 (1)

Search CenterWatch for drugs/clinical trials and news about TIAL1 / TIAR

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for TIAL1 gene (2 alternative transcripts):

NM_001033925.1 NM_003252.3

Unigene Cluster for TIAL1:

TIA1 cytotoxic granule-associated RNA binding protein-like 1

Hs.501203 [show with all ESTs]

Unigene Representative Sequence: NM_001033925

14 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000369093(uc001leh.1 uc001lei.1 uc001lej.1) ENST00000463089

ENST00000489822(uc010qtb.1) ENST00000497671(uc001lek.1) ENST00000470781

ENST00000436547 ENST00000369087 ENST00000495821 ENST00000470635 ENST00000412524

ENST00000369086 ENST00000462373 ENST00000479729 ENST00000369092

miRNA Products:		OriGene 3'-UTR Clone (see all 2): TIAL1 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TIAL1
		8/26 QIAGEN miScript miRNA Assays for microRNAs that regulate TIAL1 (see all 26):
		hsa-miR-21* hsa-miR-300 hsa-miR-624 hsa-miR-197 hsa-miR-759 hsa-miR-1297 hsa-miR-890 hsa-miR-511

		SwitchGear 3'UTR luciferase reporter plasmid: TIAL1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TIAL1 (see all 7) OriGene shRNA RFP: TIAL1 OriGene siRNA: TIAL1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TIAL1

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TIAL1 (see all 5) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TIAL1 (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): TIAL1 (NM_003252)
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		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TIAL1

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TIAL1 Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TIAL1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TIAL1

Additional cDNA sequence:

AB209260.1 AK125264.1 AK290695.1 AK290984.1 AK291239.1 AK295243.1 AL833106.1 AY633610.1

BC030025.1 BC128140.1 BC128141.1 D64015.1 M96954.1

23 DOTS entries:

DT.91753152 DT.92429719 DT.91651752 DT.97847277 DT.108784 DT.99987839 DT.100661560 DT.40105991

DT.75197813 DT.100661558 DT.92429710 DT.100036482 DT.121219191 DT.100661556 DT.102828636 DT.121219175

DT.75199696 DT.87017328 DT.92026162 DT.92035148 DT.92429709 DT.91825311 DT.97814716

24/378 AceView cDNA sequences (see all 378):

AA806424 W72125 AA504148 AL700149 BE328014 N39994 AA826209 AW294496

BQ268371 CB157414 BQ001953 BU580366 BM978957 N39410 AI701560 AI570856

BQ773815 CA432261 CB243773 AI351478 BM820306 AI371474 BQ010374 BI758963

GeneLoc Exon Structure

5/12 Alternative Splicing Database (ASD) splice patterns (SP) for TIAL1 (see all 12) About this scheme

ExUns:	1	^	2	^	3a	·	3b	·	3c	^	4a	·	4b	^	5	^	6a	·	6b	·	6c	^	7	^	8	^	9a	·	9b	^	10a	·	10b	^	11a	·	11b	^	12a	·	12b	^	13a	·	13b	^	14	^	15a	·	15b	^
SP1:			-								-										-		-		-		-				-																-
SP2:			-								-										-		-		-		-				-
SP3:																					-		-		-		-				-																-
SP4:																					-		-		-		-				-
SP5:																											-				-

ExUns:	16a	·	16b	·	16c
SP1:
SP2:
SP3:
SP4:
SP5:

ECgene alternative splicing isoforms for TIAL1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TIAL1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

About this image

TIAL1 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Kidney

Cap Mesenchyme

Cap Mesenchyme Cells

Kidney

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See TIAL1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TIAL1

SOURCE GeneReport for Unigene cluster: Hs.501203

SABiosciences Expression via Pathway-Focused PCR Array including TIAL1:

Apoptosis 384HT in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TIAL1 Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TIAL1

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TIAL1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for TIAL1 gene from 9/27 species (see all 27) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Tial1^{1 , 5}	Tia1 cytotoxic granule-associated RNA binding protein-like more^{1, 5}	94.81(n)¹ 99.23(a)¹		7 (70.20 cM)⁵ 21843¹ NM_009383.2¹ NP_033409.1¹ 128439777⁵
chicken (Gallus gallus)	Aves	TIAL1¹	TIA1 cytotoxic granule-associated RNA binding protein-like more	89.78(n) 96.91(a)		374274 NM_204356.1 NP_989687.1
lizard (Anolis carolinensis)	Reptilia	TIAL1⁶	--	96(a)	1 ↔ 1	3(66354562-66366429)
African clawed frog (Xenopus laevis)	Amphibia	tial1-A-prov²	TIA1 cytotoxic granule-associated RNA binding protein-like more	82.28(n)		AJ416631.1
zebrafish (Danio rerio)	Actinopterygii	zgc66130²	similar to TIA1 cytotoxic granule-associated RNA binding more	79.22(n)		394107 BC055501.1
fruit fly (Drosophila melanogaster)	Insecta	CG4787³ Rox8¹	RNA binding³ CG5422-PB¹	62(a)³ 55.6(n)¹ 55.47(a)¹		98C2³ 42848¹ NM_170118.1¹ NP_732944.1¹
worm (Caenorhabditis elegans)	Secernentea	C18A3.5a³ tiar-1¹	RNA binding protein³ Protein TIAR-1¹	51(a) (best of 4)³ 53.24(n)¹ 50(a)¹		II(5712808-5714773)³ 173967¹ NM_062720.2¹ NP_495121.1¹
thale cress (Arabidopsis thaliana)	eudicotyledons	UBP1B¹	oligouridylate binding protein 1B	51.54(n) 43.17(a)		838309 NM_001123829.1 NP_001117301.1
rice (Oryza sativa)	Liliopsida	Os11g0620100¹	hypothetical protein	53.14(n) 45.76(a)		4350940 NM_001074824.1 NP_001068292.1

ENSEMBL Gene Tree for TIAL1 (if available)
TreeFam Gene Tree for TIAL1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for TIAL1 gene

TIA1²

18/23 SIMAP similar genes for TIAL1 using alignment to 6 protein entries: TIAR_HUMAN (see all proteins) (see all similar genes):

TIA1 CIRBP RBMY1A1 RBM23 CSTF2 RALY

CELF3 ELAVL2 ELAVL4 PABPC4 ELAVL1 PABPC3

HNRPR RBM7 PUF60 HNRNPA1 SYNCRIP PABPC1L

TIAL1 for paralogs About GeneDecksing

1 Pseudogenes.org Pseudogene for TIAL1
PGOHUM00000243189

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 10 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs12266804^1,2		--	114962088(+)	`gattgC/Taccac`	2	--	ds500¹		0	--	--	--	--
rs11199022^1,2	C,H	--	114962514(+)	`TTTCAG/AATTAA`	2	--	ds500¹		7		NS EA NA	704
rs73366845^1,2	C,	--	114962529(+)	`AAGGAC/AACTTC`	2	--	ds500¹		1		WA	2
rs11813471^1,2	C,H	--	114962551(+)	`TACTGT/GGGCAA`	2	--	ut3¹ ese³		6		NS EA NA	420
rs3009878^1,2	C,H	--	114962855(+)	`TAAGGG/ATATAT`	2	--	ut3¹		2		NS NA	228
rs73366846^1,2	C,	--	114964034(+)	`GATTTC/TCCCCC`	2	--	ut3¹		1		WA	2
rs11199023^1,2	H	--	114964351(+)	`TCCCAG/TGTTTT`	2	--	ut3¹		4		NS EA	418
rs11199024^1,2	C,F,H,	--	114965225(+)	`AAAGCT/AATGGG`	2	--	int¹		5		NS EA WA	522
rs7088869^1,2	C,F,H,	--	114966099(+)	`TTCCAA/GAGCTT`	2	--	int¹		6		NS EA WA CSA	420
rs12245766^1,2	C,H	--	114966151(+)	`AAAATC/GGAATT`	2	--	int¹		4		NS EA	418

HapMap Linkage Disequilibrium report for TIAL1 (121332977 - 121356541 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for TIAL1: --

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

TIAL1 for disorders           About GeneDecksing

OMIM gene information: 603413    OMIM disorders: --

19 diseases for TIAL1:    About MalaCards

spinal muscular atrophy west nile virus muscular atrophy amyotrophic lateral sclerosis

lateral sclerosis systemic lupus erythematosus lupus erythematosus inflammatory bowel disease

herpes simplex neurofibromatosis breast cancer ischemia

cerebritis hypoxia retinitis schizophrenia

thyroiditis prostatitis neuronitis

2 Novoseek disease relationships for TIAL1 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
necrosis	0	2	9890998 (1), 18438838 (1)
tumors	0	3	15474296 (1), 9890998 (1), 18438838 (1)

Export disorders for TIAL1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for TIAL1 gene, integrated from 9 sources (see all 82):
(articles sorted by number of sources associating them with TIAL1)

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world of online information

Identification and functional characterization of a TIA-1-related nucleolysin. (PubMed id 1326761)^{1, 2, 3, 9} Kawakami A....Anderson P. (1992)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
TIA-1 or TIAR is required for DT40 cell viability. (PubMed id 12533540)^{1, 9} Le Guiner C....Breathnach R. (2003)
An alternative form of nucleolysin binds to a T-cluster DNA in the silencer element of platelet factor 4 gene. (PubMed id 9207209)^{1, 9} Doi T.... Imanishi T. (1997)
U1 snRNP-dependent function of TIAR in the regulation of alternative RNA processing of the human calcitonin/CGRP pre-mRNA. (PubMed id 12917321)^{1, 9} Zhu H....Lou H. (2003)
The RNA-binding protein TIAR is translocated from the nucleus to the cytoplasm during Fas-mediated apoptotic cell death. (PubMed id 7533298)^{1, 9} Taupin J.L....Anderson P. (1995)
Elucidation of a C-rich signature motif in target mRNAs of RNA-binding protein TIAR. (PubMed id 17682065)^{1, 9} Kim H.S....Wilce J.A. (2007)
Individual RNA recognition motifs of TIA-1 and TIAR have different RNA binding specificities. (PubMed id 8576255)^{1, 9} Dember L.M....Anderson P. (1996)
Control of the ATP synthase beta subunit expression by RNA-binding proteins TIA-1, TIAR, and HuR. (PubMed id 16890199)^{1, 9} Izquierdo J.M. (2006)
Competitive binding of AUF1 and TIAR to MYC mRNA controls its translation. (PubMed id 17486099)^{1, 9} Liao B....Brewer G. (2007)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 7073	HGNC: 11804	AceView: TIAL1	Ensembl:ENSG00000151923	euGenes: HUgn7073
ECgene: TIAL1	H-InvDB: TIAL1

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for TIAL1	Pharmacogenomics, SNPs, Pathways

Intellectual Property for TIAL1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for TIAL1 gene:
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GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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