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Aliases for TIAL1 Gene

Aliases for TIAL1 Gene

  • TIA1 Cytotoxic Granule Associated RNA Binding Protein Like 1 2 3 5
  • TIA1 Cytotoxic Granule-Associated RNA-Binding Protein-Like 1 2
  • Aging-Associated Gene 7 Protein 3
  • T-Cluster Binding Protein 3
  • TIA-1-Related Nucleolysin 3
  • TIA-1-Related Protein 4
  • Nucleolysin TIAR 3
  • TCBP 3
  • TIAR 3

External Ids for TIAL1 Gene

Previous GeneCards Identifiers for TIAL1 Gene

  • GC10M120253
  • GC10M120578
  • GC10M121466
  • GC10M120999
  • GC10M121324
  • GC10M114963

Summaries for TIAL1 Gene

Entrez Gene Summary for TIAL1 Gene

  • The protein encoded by this gene is a member of a family of RNA-binding proteins, has three RNA recognition motifs (RRMs), and binds adenine and uridine-rich elements in mRNA and pre-mRNAs of a wide range of genes. It regulates various activities including translational control, splicing and apoptosis. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The different isoforms have been show to function differently with respect to post-transcriptional silencing. [provided by RefSeq, Jul 2008]

GeneCards Summary for TIAL1 Gene

TIAL1 (TIA1 Cytotoxic Granule Associated RNA Binding Protein Like 1) is a Protein Coding gene. Among its related pathways are Apoptosis and Autophagy and Signaling by FGFR2. GO annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is TIA1.

UniProtKB/Swiss-Prot for TIAL1 Gene

  • RNA-binding protein. Possesses nucleolytic activity against cytotoxic lymphocyte target cells. May be involved in apoptosis.

Gene Wiki entry for TIAL1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TIAL1 Gene

Genomics for TIAL1 Gene

Regulatory Elements for TIAL1 Gene

Enhancers for TIAL1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH10G119515 1.7 FANTOM5 Ensembl ENCODE dbSUPER 11.3 +79.1 79068 5.4 HDGF TCF12 ZNF263 CAVIN1 JUNB TBX21 ZNF592 SMARCA4 NBN SP7 RGS10 TIAL1 EIF3A GC10P119418
GH10G119498 1.5 Ensembl ENCODE dbSUPER 11.3 +95.9 95877 5.6 PKNOX1 FOXA2 MLX ARID4B FEZF1 FOS ZNF263 MIER2 PPARG TBX21 RGS10 TIAL1 GC10P119418
GH10G119521 1.4 Ensembl ENCODE dbSUPER 11.3 +74.4 74436 2.4 ELF3 INSM2 SIN3A THRB RARA ZNF366 FOS CEBPB ZNF592 ZNF579 TIAL1 RGS10 GC10P119418
GH10G119494 1.4 Ensembl ENCODE dbSUPER 11.3 +101.7 101718 2.9 HDAC1 PKNOX1 FOXA2 TBL1XR1 FEZF1 TCF12 ZNF121 ZSCAN5C FOS RELB RGS10 TIAL1 GC10P119418
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TIAL1 on UCSC Golden Path with GeneCards custom track

Promoters for TIAL1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for TIAL1 Gene

119,571,802 bp from pter
119,597,029 bp from pter
25,228 bases
Minus strand

Genomic View for TIAL1 Gene

Genes around TIAL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TIAL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TIAL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TIAL1 Gene

Proteins for TIAL1 Gene

  • Protein details for TIAL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Nucleolysin TIAR
    Protein Accession:
    Secondary Accessions:
    • A8K3T0
    • A8K4L9

    Protein attributes for TIAL1 Gene

    375 amino acids
    Molecular mass:
    41591 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for TIAL1 Gene

    Alternative splice isoforms for TIAL1 Gene


neXtProt entry for TIAL1 Gene

Post-translational modifications for TIAL1 Gene

  • Phosphorylated by MAPK14 following DNA damage, releasing TIAR from GADD45A mRNA.
  • Ubiquitination at posLast=122122 and Lys203
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for TIAL1 Gene

Domains & Families for TIAL1 Gene

Gene Families for TIAL1 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TIAL1: view

No data available for UniProtKB/Swiss-Prot for TIAL1 Gene

Function for TIAL1 Gene

Molecular function for TIAL1 Gene

UniProtKB/Swiss-Prot Function:
RNA-binding protein. Possesses nucleolytic activity against cytotoxic lymphocyte target cells. May be involved in apoptosis.

Gene Ontology (GO) - Molecular Function for TIAL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0003723 RNA binding TAS,IDA 22658674
GO:0017091 AU-rich element binding IEA --
genes like me logo Genes that share ontologies with TIAL1: view
genes like me logo Genes that share phenotypes with TIAL1: view

Animal Models for TIAL1 Gene

MGI Knock Outs for TIAL1:

Animal Model Products

CRISPR Products

miRNA for TIAL1 Gene

miRTarBase miRNAs that target TIAL1

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TIAL1 Gene

Localization for TIAL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TIAL1 Gene

Cytoplasm. Nucleus. Cytoplasmic granule. Note=The cytoplasmic granules are stress granules which are a dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress. Colocalizes with NANOS3 in the stress granules (By similarity). Cytoplasmic granules of cytolytic T-lymphocytes. {ECO:0000250}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TIAL1 gene
Compartment Confidence
extracellular 5
nucleus 5
lysosome 4
cytosol 3

Gene Ontology (GO) - Cellular Components for TIAL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,ISS --
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm ISS --
GO:0005764 lysosome TAS 1326761
GO:0010494 cytoplasmic stress granule ISS --
genes like me logo Genes that share ontologies with TIAL1: view

Pathways & Interactions for TIAL1 Gene

genes like me logo Genes that share pathways with TIAL1: view

Pathways by source for TIAL1 Gene

Gene Ontology (GO) - Biological Process for TIAL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006357 regulation of transcription from RNA polymerase II promoter TAS 9207209
GO:0006915 apoptotic process TAS,IEA --
GO:0006952 defense response TAS 1326761
GO:0007281 germ cell development IEA --
GO:0008284 positive regulation of cell proliferation IEA --
genes like me logo Genes that share ontologies with TIAL1: view

No data available for SIGNOR curated interactions for TIAL1 Gene

Drugs & Compounds for TIAL1 Gene

(3) Drugs for TIAL1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for TIAL1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with TIAL1: view

Transcripts for TIAL1 Gene

Unigene Clusters for TIAL1 Gene

TIA1 cytotoxic granule-associated RNA binding protein-like 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for TIAL1 Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15a · 15b ^
SP1: - - - - - - - -
SP2: - - - - - - -
SP3: - - - - - -
SP4: - - - - -
SP5: - -
SP6: - -
SP7: -
SP8: - -
SP9: -

ExUns: 16a · 16b · 16c

Relevant External Links for TIAL1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TIAL1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TIAL1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TIAL1 Gene

This gene is overexpressed in Bone (10.5) and Peripheral blood mononuclear cells (7.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TIAL1 Gene

Protein tissue co-expression partners for TIAL1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TIAL1 Gene:


SOURCE GeneReport for Unigene cluster for TIAL1 Gene:


Evidence on tissue expression from TISSUES for TIAL1 Gene

  • Lung(4.4)
  • Nervous system(3.3)
  • Blood(2.1)
  • Kidney(2.1)
  • Stomach(2)
genes like me logo Genes that share expression patterns with TIAL1: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TIAL1 Gene

Orthologs for TIAL1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TIAL1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TIAL1 34 35
  • 99.74 (n)
(Monodelphis domestica)
Mammalia TIAL1 35
  • 98 (a)
(Canis familiaris)
Mammalia TIAL1 34 35
  • 97.28 (n)
(Bos Taurus)
Mammalia TIAL1 34 35
  • 95.56 (n)
(Ornithorhynchus anatinus)
Mammalia TIAL1 35
  • 95 (a)
(Rattus norvegicus)
Mammalia Tial1 34
  • 94.98 (n)
(Mus musculus)
Mammalia Tial1 34 16 35
  • 94.81 (n)
(Gallus gallus)
Aves TIAR 35
  • 98 (a)
TIA1 34
  • 87.89 (n)
(Anolis carolinensis)
Reptilia TIAL1 35
  • 92 (a)
African clawed frog
(Xenopus laevis)
Amphibia tial1-A-prov 34
(Danio rerio)
Actinopterygii tial1 34 35
  • 76.4 (n)
zgc66130 34
fruit fly
(Drosophila melanogaster)
Insecta CG4787 36
  • 62 (a)
Rox8 34 35
  • 55.84 (n)
CG34354 35
  • 30 (a)
CG34362 35
  • 20 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002335 34
  • 54.47 (n)
(Caenorhabditis elegans)
Secernentea C18A3.5a 36
  • 51 (a)
C07A4.1 36
  • 46 (a)
C18A3.5b 36
  • 44 (a)
Y46G5A.13 36
  • 44 (a)
tiar-1 35
  • 39 (a)
tiar-2 35
  • 34 (a)
tiar-3 35
  • 26 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PUB1 35
  • 26 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons UBP1B 34
  • 52.01 (n)
(Oryza sativa)
Liliopsida Os11g0620100 34
  • 53.14 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8430 35
  • 48 (a)
-- 35
  • 30 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5046 34
Species where no ortholog for TIAL1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for TIAL1 Gene

Gene Tree for TIAL1 (if available)
Gene Tree for TIAL1 (if available)

Paralogs for TIAL1 Gene

Paralogs for TIAL1 Gene Pseudogenes for TIAL1 Gene

genes like me logo Genes that share paralogs with TIAL1: view

Variants for TIAL1 Gene

Sequence variations from dbSNP and Humsavar for TIAL1 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs1000047430 -- 119,583,780(+) ACTGA(C/G)AACAA intron-variant
rs1000166312 -- 119,575,261(+) TATAT(A/G)TGATT nc-transcript-variant, utr-variant-3-prime
rs1000431168 -- 119,590,798(+) AAAGA(A/G)AGAAA intron-variant
rs1000500974 -- 119,573,585(+) TGGCA(C/G)ACCAA nc-transcript-variant, utr-variant-3-prime
rs1000651334 -- 119,582,083(+) TAGAG(A/G)AGGAA intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for TIAL1 Gene

Variant ID Type Subtype PubMed ID
nsv1044497 CNV gain 25217958
nsv552215 CNV loss 21841781

Variation tolerance for TIAL1 Gene

Residual Variation Intolerance Score: 27.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.14; 3.27% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TIAL1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TIAL1 Gene

Disorders for TIAL1 Gene

Relevant External Links for TIAL1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for TIAL1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TIAL1 Gene

Publications for TIAL1 Gene

  1. Identification and functional characterization of a TIA-1-related nucleolysin. (PMID: 1326761) Kawakami A. … Anderson P. (Proc. Natl. Acad. Sci. U.S.A. 1992) 2 3 4 22 64
  2. DNA damage activates a spatially distinct late cytoplasmic cell-cycle checkpoint network controlled by MK2-mediated RNA stabilization. (PMID: 20932473) Reinhardt H.C. … Yaffe M.B. (Mol. Cell 2010) 3 4 64
  3. A systematic analysis of intronic sequences downstream of 5' splice sites reveals a widespread role for U-rich motifs and TIA1/TIAL1 proteins in alternative splicing regulation. (PMID: 18456862) Aznarez I. … Blencowe B.J. (Genome Res. 2008) 3 22 64
  4. Competitive binding of AUF1 and TIAR to MYC mRNA controls its translation. (PMID: 17486099) Liao B. … Brewer G. (Nat. Struct. Mol. Biol. 2007) 3 22 64
  5. Two isoforms of the T-cell intracellular antigen 1 (TIA-1) splicing factor display distinct splicing regulation activities. Control of TIA-1 isoform ratio by TIA-1-related protein. (PMID: 17488725) Izquierdo J.M. … ValcA!rcel J. (J. Biol. Chem. 2007) 3 22 64

Products for TIAL1 Gene

Sources for TIAL1 Gene

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