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Aliases for TIAL1 Gene

Aliases for TIAL1 Gene

  • TIA1 Cytotoxic Granule-Associated RNA Binding Protein-Like 1 2 3
  • TCBP 3 6
  • TIAR 3 6
  • TIA1 Cytotoxic Granule-Associated RNA-Binding Protein-Like 1 2
  • Aging-Associated Gene 7 Protein 3
  • T-Cluster Binding Protein 3
  • TIA-1-Related Nucleolysin 3
  • TIA-1-Related Protein 4
  • Nucleolysin TIAR 3

External Ids for TIAL1 Gene

Previous GeneCards Identifiers for TIAL1 Gene

  • GC10M120253
  • GC10M120578
  • GC10M121466
  • GC10M120999
  • GC10M121324
  • GC10M114963

Summaries for TIAL1 Gene

Entrez Gene Summary for TIAL1 Gene

  • The protein encoded by this gene is a member of a family of RNA-binding proteins, has three RNA recognition motifs (RRMs), and binds adenine and uridine-rich elements in mRNA and pre-mRNAs of a wide range of genes. It regulates various activities including translational control, splicing and apoptosis. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The different isoforms have been show to function differently with respect to post-transcriptional silencing. [provided by RefSeq, Jul 2008]

GeneCards Summary for TIAL1 Gene

TIAL1 (TIA1 Cytotoxic Granule-Associated RNA Binding Protein-Like 1) is a Protein Coding gene. Among its related pathways are Translational Control and Chromatin Regulation / Acetylation. GO annotations related to this gene include RNA binding and AU-rich element binding. An important paralog of this gene is TIA1.

UniProtKB/Swiss-Prot for TIAL1 Gene

  • RNA-binding protein. Possesses nucleolytic activity against cytotoxic lymphocyte target cells. May be involved in apoptosis

Gene Wiki entry for TIAL1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TIAL1 Gene

Genomics for TIAL1 Gene

Regulatory Elements for TIAL1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TIAL1 Gene

119,571,802 bp from pter
119,597,029 bp from pter
25,228 bases
Minus strand

Genomic View for TIAL1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TIAL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TIAL1 Gene

Proteins for TIAL1 Gene

  • Protein details for TIAL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Nucleolysin TIAR
    Protein Accession:
    Secondary Accessions:
    • A8K3T0
    • A8K4L9

    Protein attributes for TIAL1 Gene

    375 amino acids
    Molecular mass:
    41591 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for TIAL1 Gene

    Alternative splice isoforms for TIAL1 Gene


neXtProt entry for TIAL1 Gene

Proteomics data for TIAL1 Gene at MOPED

Post-translational modifications for TIAL1 Gene

  • Phosphorylated by MAPK14 following DNA damage, releasing TIAR from GADD45A mRNA.
  • Ubiquitination at Lys122 and Lys203
  • Modification sites at PhosphoSitePlus

Other Protein References for TIAL1 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for TIAL1 (TIAL1)

No data available for DME Specific Peptides for TIAL1 Gene

Domains for TIAL1 Gene

Gene Families for TIAL1 Gene

  • RBM :RNA binding motif (RRM) containing

Protein Domains for TIAL1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Q01085
  • Contains 3 RRM (RNA recognition motif) domains.
genes like me logo Genes that share domains with TIAL1: view

Function for TIAL1 Gene

Molecular function for TIAL1 Gene

UniProtKB/Swiss-Prot Function: RNA-binding protein. Possesses nucleolytic activity against cytotoxic lymphocyte target cells. May be involved in apoptosis

Gene Ontology (GO) - Molecular Function for TIAL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003676 nucleic acid binding --
GO:0003723 RNA binding TAS 1326761
GO:0005515 protein binding --
GO:0017091 AU-rich element binding IEA --
genes like me logo Genes that share ontologies with TIAL1: view
genes like me logo Genes that share phenotypes with TIAL1: view

Animal Models for TIAL1 Gene

MGI Knock Outs for TIAL1:

Animal Model Products

CRISPR Products

miRNA for TIAL1 Gene

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TIAL1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for TIAL1 Gene

Localization for TIAL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TIAL1 Gene

Cytoplasm. Nucleus. Cytoplasmic granule. Note=The cytoplasmic granules are stress granules which are a dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress. Colocalizes with NANOS3 in the stress granules (By similarity). Cytoplasmic granules of cytolytic T-lymphocytes. {ECO:0000250}.

Subcellular locations from

Jensen Localization Image for TIAL1 Gene COMPARTMENTS Subcellular localization image for TIAL1 gene
Compartment Confidence
lysosome 4
nucleus 4
vacuole 4
cytosol 2

Gene Ontology (GO) - Cellular Components for TIAL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
GO:0005737 cytoplasm ISS --
GO:0005764 lysosome TAS 1326761
GO:0010494 cytoplasmic stress granule ISS --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with TIAL1: view

Pathways for TIAL1 Gene

genes like me logo Genes that share pathways with TIAL1: view

Pathways by source for TIAL1 Gene

3 Cell Signaling Technology pathways for TIAL1 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for TIAL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006357 regulation of transcription from RNA polymerase II promoter TAS 9207209
GO:0006915 apoptotic process IEA --
GO:0006952 defense response TAS 1326761
GO:0007281 germ cell development IEA --
GO:0008284 positive regulation of cell proliferation IEA --
genes like me logo Genes that share ontologies with TIAL1: view

Compounds for TIAL1 Gene

(4) Novoseek inferred chemical compound relationships for TIAL1 Gene

Compound -log(P) Hits PubMed IDs
flupirtine 74 2
uridine 36.8 1
vegf 2.2 2
atp 0 2
genes like me logo Genes that share compounds with TIAL1: view

Transcripts for TIAL1 Gene

Unigene Clusters for TIAL1 Gene

TIA1 cytotoxic granule-associated RNA binding protein-like 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TIAL1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TIAL1 Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15a · 15b ^
SP1: - - - - - - - -
SP2: - - - - - - -
SP3: - - - - - -
SP4: - - - - -
SP5: - -
SP6: - -
SP7: -
SP8: - -
SP9: -

ExUns: 16a · 16b · 16c

Relevant External Links for TIAL1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TIAL1 Gene

mRNA expression in normal human tissues for TIAL1 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TIAL1 Gene

SOURCE GeneReport for Unigene cluster for TIAL1 Gene Hs.501203

genes like me logo Genes that share expressions with TIAL1: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TIAL1 Gene

Orthologs for TIAL1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TIAL1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TIAL1 35
  • 99.74 (n)
  • 100 (a)
TIAL1 36
  • 100 (a)
(Bos Taurus)
Mammalia TIAL1 35
  • 95.56 (n)
  • 100 (a)
TIAL1 36
  • 99 (a)
(Canis familiaris)
Mammalia TIAL1 35
  • 97.28 (n)
  • 100 (a)
TIAL1 36
  • 100 (a)
(Mus musculus)
Mammalia Tial1 35
  • 94.81 (n)
  • 99.23 (a)
Tial1 16
Tial1 36
  • 99 (a)
(Monodelphis domestica)
Mammalia TIAL1 36
  • 98 (a)
(Ornithorhynchus anatinus)
Mammalia TIAL1 36
  • 95 (a)
(Rattus norvegicus)
Mammalia Tial1 35
  • 94.98 (n)
  • 99.23 (a)
(Gallus gallus)
Aves TIA1 35
  • 87.89 (n)
  • 95.1 (a)
  • 98 (a)
(Anolis carolinensis)
Reptilia TIAL1 36
  • 92 (a)
African clawed frog
(Xenopus laevis)
Amphibia tial1-A-prov 35
(Danio rerio)
Actinopterygii tial1 35
  • 76.4 (n)
  • 85.14 (a)
tial1 36
  • 85 (a)
zgc66130 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002335 35
  • 54.47 (n)
  • 56.16 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG34354 36
  • 30 (a)
CG34362 36
  • 20 (a)
Rox8 35
  • 55.84 (n)
  • 55.47 (a)
Rox8 36
  • 38 (a)
CG4787 37
  • 62 (a)
(Caenorhabditis elegans)
Secernentea tiar-1 36
  • 39 (a)
tiar-2 36
  • 34 (a)
tiar-3 36
  • 26 (a)
C07A4.1 37
  • 46 (a)
Y46G5A.13 37
  • 44 (a)
C18A3.5a 37
  • 51 (a)
C18A3.5b 37
  • 44 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PUB1 36
  • 26 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons UBP1B 35
  • 52.01 (n)
  • 43.61 (a)
(Oryza sativa)
Liliopsida Os11g0620100 35
  • 53.14 (n)
  • 45.76 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5046 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 30 (a)
CSA.8430 36
  • 48 (a)
Species with no ortholog for TIAL1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for TIAL1 Gene

Gene Tree for TIAL1 (if available)
Gene Tree for TIAL1 (if available)

Paralogs for TIAL1 Gene

Paralogs for TIAL1 Gene Pseudogenes for TIAL1 Gene

genes like me logo Genes that share paralogs with TIAL1: view

Variants for TIAL1 Gene

Sequence variations from dbSNP and Humsavar for TIAL1 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs1060033 -- 119,576,880(-) TTAGA(C/T)AATGA intron-variant, utr-variant-3-prime, nc-transcript-variant
rs1060034 -- 119,576,879(-) TAGAC(A/G)ATGAT intron-variant, utr-variant-3-prime, nc-transcript-variant
rs2069142 -- 119,582,875(-) GATCT(G/T)AGTTT intron-variant
rs2420637 -- 119,597,146(+) GTGGG(A/G)AAAAG upstream-variant-2KB
rs2901215 -- 119,597,066(+) GGACG(G/T)GCGAC upstream-variant-2KB

Relevant External Links for TIAL1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TIAL1 Gene

Disorders for TIAL1 Gene

(2) Novoseek inferred disease relationships for TIAL1 Gene

Disease -log(P) Hits PubMed IDs
necrosis 0 2
tumors 0 3
genes like me logo Genes that share disorders with TIAL1: view

No data available for UniProtKB/Swiss-Prot for TIAL1 Gene

Publications for TIAL1 Gene

  1. Identification and functional characterization of a TIA-1-related nucleolysin. (PMID: 1326761) Kawakami A. … Anderson P. (Proc. Natl. Acad. Sci. U.S.A. 1992) 2 3 4 23
  2. The RNA-binding protein TIAR is translocated from the nucleus to the cytoplasm during Fas-mediated apoptotic cell death. (PMID: 7533298) Taupin J.L. … Anderson P. (Proc. Natl. Acad. Sci. U.S.A. 1995) 3 23
  3. Individual RNA recognition motifs of TIA-1 and TIAR have different RNA binding specificities. (PMID: 8576255) Dember L.M. … Anderson P. (J. Biol. Chem. 1996) 3 23
  4. TIA-1 and TIAR activate splicing of alternative exons with weak 5' splice sites followed by a U-rich stretch on their own pre-mRNAs. (PMID: 11514562) Le Guiner C. … Del Gatto-Konczak F. (J. Biol. Chem. 2001) 3 23
  5. An alternative form of nucleolysin binds to a T-cluster DNA in the silencer element of platelet factor 4 gene. (PMID: 9207209) Doi T. … Imanishi T. (Biochem. Biophys. Res. Commun. 1997) 3 23

Products for TIAL1 Gene

Sources for TIAL1 Gene

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