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TIAL1 Gene

protein-coding   GIFtS: 54
GCID: GC10M121324

TIA1 Cytotoxic Granule-Associated RNA Binding Protein-Like...

(Previous name: TIA1 cytotoxic granule-associated RNA-binding protein-like...)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
TIA1 Cytotoxic Granule-Associated RNA Binding Protein-Like 11 2     Nucleolysin TIAR2
TCBP2 5     T-Cluster Binding Protein2
TIAR2 5     TIA-1-Related Nucleolysin2
TIA1 Cytotoxic Granule-Associated RNA-Binding Protein-Like 11     TIA-1-Related Protein3
Aging-Associated Gene 7 Protein2     

External Ids:    HGNC: 118041   Entrez Gene: 70732   Ensembl: ENSG000001519237   OMIM: 6034135   UniProtKB: Q010853   

Export aliases for TIAL1 gene to outside databases

Previous GC identifers: GC10M120253 GC10M120578 GC10M121466 GC10M120999 GC10M114963


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TIAL1 Gene:
The protein encoded by this gene is a member of a family of RNA-binding proteins, has three RNA recognition motifs
(RRMs), and binds adenine and uridine-rich elements in mRNA and pre-mRNAs of a wide range of genes. It regulates
various activities including translational control, splicing and apoptosis. Alternate transcriptional splice
variants, encoding different isoforms, have been characterized. The different isoforms have been show to function
differently with respect to post-transcriptional silencing. (provided by RefSeq, Jul 2008)

GeneCards Summary for TIAL1 Gene:
TIAL1 (TIA1 cytotoxic granule-associated RNA binding protein-like 1) is a protein-coding gene. Diseases associated with TIAL1 include west nile virus, and spinal muscular atrophy. GO annotations related to this gene include RNA binding and AU-rich element binding. An important paralog of this gene is TIA1.

UniProtKB/Swiss-Prot: TIAR_HUMAN, Q01085
Function: RNA-binding protein. Possesses nucleolytic activity against cytotoxic lymphocyte target cells. May be
involved in apoptosis

Gene Wiki entry for TIAL1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000010.11  NT_030059.14  NC_018921.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TIAL1 gene promoter:
         GR   GR-beta   Meis-1b   C/EBPalpha   CHOP-10   FOXJ2 (long isoform)   c-Myb   GR-alpha   Meis-1a   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): TIAL1 promoter sequence
   Search Chromatin IP Primers for TIAL1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TIAL1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q   Ensembl cytogenetic band:  10q26.11   HGNC cytogenetic band: 10q

TIAL1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TIAL1 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M121324:  view genomic region     (about GC identifiers)

Start:
121,332,977 bp from pter      End:
121,356,541 bp from pter
Size:
23,565 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: TIAR_HUMAN, Q01085 (See protein sequence)
Recommended Name: Nucleolysin TIAR  
Size: 375 amino acids; 41591 Da
3 PDB 3D structures from and Proteopedia for TIAL1:
1X4G (3D)        2CQI (3D)        2DH7 (3D)    
Secondary accessions: A8K3T0 A8K4L9
Alternative splicing: 2 isoforms:  Q01085-1   Q01085-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TIAL1: NX_Q01085

Explore proteomics data for TIAL1 at MOPED

Post-translational modifications: 

  • Phosphorylated by MAPK14 following DNA damage, releasing TIAR from GADD45A mRNA1
  • Ubiquitination2 at Lys122, Lys203
  • Modification sites at PhosphoSitePlus

  • See TIAL1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001029097.1  NP_003243.1  

    ENSEMBL proteins: 
     ENSP00000358089   ENSP00000431009   ENSP00000394902   ENSP00000403573   ENSP00000358082  
     ENSP00000358088  

    TIAL1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for TIAL1
    OriGene Protein Over-expression Lysate for TIAL1
    OriGene Custom MassSpec
    OriGene Custom Protein Services for TIAL1
    GenScript Custom Purified and Recombinant Proteins Services for TIAL1
    Novus Biologicals TIAL1 Proteins
    Novus Biologicals TIAL1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for TIAL1

    TIAL1 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Cell Signaling Technology (CST) Antibodies for TIAL1 
    OriGene Antibodies for TIAL1
    OriGene Custom Antibody Services for TIAL1
    Novus Biologicals TIAL1 Antibodies
    Abcam antibodies for TIAL1
    Cloud-Clone Corp. Antibodies for TIAL1
    ThermoFisher Antibodies for TIAL1
    LSBio Antibodies in human, mouse, rat for TIAL1

    TIAL1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for TIAL1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for TIAL1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for TIAL1
    Cloud-Clone Corp. CLIAs for TIAL1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    RBM: RNA binding motif (RRM) containing

    2 InterPro protein domains:
     IPR000504 RRM_dom
     IPR012677 Nucleotide-bd_a/b_plait

    Graphical View of Domain Structure for InterPro Entry Q01085

    ProtoNet protein and cluster: Q01085

    1 Blocks protein domain: IPB000504 RNA-binding region RNP-1 (RNA recognition motif)

    UniProtKB/Swiss-Prot: TIAR_HUMAN, Q01085
    Similarity: Contains 3 RRM (RNA recognition motif) domains


    TIAL1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TIAR_HUMAN, Q01085
    Function: RNA-binding protein. Possesses nucleolytic activity against cytotoxic lymphocyte target cells. May be
    involved in apoptosis

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding IEA--
    GO:0003676nucleic acid binding ----
    GO:0003723RNA binding TAS1326761
    GO:0005515protein binding ----
    GO:0017091AU-rich element binding IEA--
         
    TIAL1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for TIAL1:
     Increased G1 DNA content 

         5 MGI mutant phenotypes (inferred from 1 allele(MGI details for Tial1):
     embryogenesis  endocrine/exocrine gland  growth/size/body  mortality/aging  reproductive system 

    TIAL1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Tial1tm1Mst for TIAL1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TIAL1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TIAL1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TIAL1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TIAL1

    miRNA
    Products:
        
    miRTarBase miRNAs that target TIAL1:
    hsa-mir-181a-5p (MIRT025099), hsa-mir-27a-3p (MIRT028690), hsa-mir-30a-5p (MIRT028531), hsa-mir-181c-5p (MIRT047221)

    Block miRNA regulation of human, mouse, rat TIAL1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TIAL1 (see all 26):
    hsa-miR-21* hsa-miR-300 hsa-miR-624 hsa-miR-197 hsa-miR-759 hsa-miR-1297 hsa-miR-890 hsa-miR-511
    SwitchGear 3'UTR luciferase reporter plasmidTIAL1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for TIAL1
    Predesigned siRNA for gene silencing in human, mouse, rat TIAL1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for TIAL1

    Clone
    Products:
         
    OriGene clones in human, mouse for TIAL1 (see all 12)
    OriGene ORF clones in mouse, rat for TIAL1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): TIAL1 (NM_003252)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TIAL1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TIAL1

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for TIAL1
    Browse ESI BIO Cell Lines and PureStem Progenitors for TIAL1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TIAL1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TIAR_HUMAN, Q01085: Cytoplasm (By similarity). Nucleus (By similarity). Cytoplasmic granule. Note=The
    cytoplasmic granules are stress granules which are a dense aggregation in the cytosol composed of proteins and
    RNAs that appear when the cell is under stress. Colocalizes with NANOS3 in the stress granules (By similarity).
    Cytoplasmic granules of cytolytic T-lymphocytes
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    lysosome4
    nucleus4
    vacuole4
    cytosol2

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ISS--
    GO:0005737cytoplasm ISS--
    GO:0005764lysosome TAS1326761
    GO:0010494cytoplasmic stress granule ISS--

    TIAL1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TIAL1 About    
    See pathways by source

    SuperPathContained pathways About
    1Translational Control
    Translational Control
    2Chromatin Regulation / Acetylation
    Chromatin Regulation / Acetylation
    3Apoptosis and Autophagy
    Apoptosis and Autophagy

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    3 Cell Signaling Technology (CST) Pathways for TIAL1
        Chromatin Regulation / Acetylation
    Apoptosis and Autophagy
    Translational Control



    TIAL1 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including TIAL1: 
              Apoptosis 384HT in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for TIAL1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for TIAL1 (Q010852, 3 ENSP000003580894) via UniProtKB, MINT, STRING, and/or I2D (see all 887)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SMN1Q166372, 3, ENSP000003700834MINT-7945693 MINT-50604 MINT-50603 MINT-7947479 I2D: score=3 STRING: ENSP00000370083
    SMN2Q166372, 3, ENSP000003701194MINT-7945693 MINT-50604 MINT-50603 MINT-7947479 I2D: score=3 STRING: ENSP00000370119
    SNRPD3P623182, 3, ENSP000002158294MINT-7945693 MINT-7947479 I2D: score=4 STRING: ENSP00000215829
    DDX5P178442, 3, ENSP000002257924MINT-7945693 MINT-7947479 I2D: score=1 STRING: ENSP00000225792
    EEF1A1P681042, 3MINT-7945693 MINT-7947479 I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006357regulation of transcription from RNA polymerase II promoter TAS9207209
    GO:0006915apoptotic process IEA--
    GO:0006952defense response TAS1326761
    GO:0007281germ cell development IEA--
    GO:0008284positive regulation of cell proliferation IEA--

    TIAL1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TIAL1 (TIAR)

    4 Novoseek inferred chemical compound relationships for TIAL1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    flupirtine 74 2 9804146 (1), 9191602 (1)
    uridine 36.8 1 16890199 (1)
    vegf 2.2 3 16091628 (1), 11456315 (1)
    atp 0 7 16890199 (1), 17466948 (1)



    TIAL1 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for TIAL1 gene (2 alternative transcripts): 
    NM_001033925.1  NM_003252.3  

    Unigene Cluster for TIAL1:

    TIA1 cytotoxic granule-associated RNA binding protein-like 1
    Hs.501203  [show with all ESTs]
    Unigene Representative Sequence: NM_001033925
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000369093(uc001leh.1 uc001lei.1 uc001lej.1) ENST00000463089
    ENST00000489822(uc010qtb.1) ENST00000497671(uc001lek.1) ENST00000470781
    ENST00000436547 ENST00000369087 ENST00000495821 ENST00000470635 ENST00000412524
    ENST00000369086 ENST00000462373 ENST00000479729 ENST00000369092
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat TIAL1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TIAL1 (see all 26):
    hsa-miR-21* hsa-miR-300 hsa-miR-624 hsa-miR-197 hsa-miR-759 hsa-miR-1297 hsa-miR-890 hsa-miR-511
    SwitchGear 3'UTR luciferase reporter plasmidTIAL1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for TIAL1
    Predesigned siRNA for gene silencing in human, mouse, rat TIAL1
    Clone
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    OriGene clones in human, mouse for TIAL1 (see all 12)
    OriGene ORF clones in mouse, rat for TIAL1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): TIAL1 (NM_003252)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TIAL1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TIAL1
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for TIAL1
    OriGene qSTAR qPCR primer pairs in human, mouse for TIAL1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TIAL1
      QuantiTect SYBR Green Assays in human, mouse, rat TIAL1
      QuantiFast Probe-based Assays in human, mouse, rat TIAL1

    Additional mRNA sequence: 

    AB209260.1 AK125264.1 AK290695.1 AK290984.1 AK291239.1 AK295243.1 AL833106.1 AY633610.1 
    BC030025.1 BC128140.1 BC128141.1 D64015.1 M96954.1 

    23 DOTS entries:

    DT.91753152  DT.92429719  DT.91651752  DT.97847277  DT.108784  DT.99987839  DT.100661560  DT.40105991 
    DT.75197813  DT.100661558  DT.92429710  DT.100036482  DT.121219191  DT.100661556  DT.102828636  DT.121219175 
    DT.75199696  DT.87017328  DT.92026162  DT.92035148  DT.92429709  DT.91825311  DT.97814716 

    Selected AceView cDNA sequences (see all 378):

    BQ268371 AA126766 BU580821 AI924569 AA744849 NM_022333 BQ002839 BQ000729 
    AI479531 AI890525 BI758963 CR621940 BU580366 BF433020 BU688962 BM980674 
    BM795980 BG575419 BQ001953 AA422177 CB143004 AA788747 BC030025 CB155494 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for TIAL1 (see all 12)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15a · 15b ^
    SP1:        -                       -                             -     -     -     -           -                                               -               
    SP2:        -                       -                             -     -     -     -           -                                                               
    SP3:                                                              -     -     -     -           -                                               -               
    SP4:                                                              -     -     -     -           -                                                               
    SP5:                                                                                -           -                                                               

    ExUns: 16a · 16b · 16c
    SP1:                  
    SP2:                  
    SP3:                  
    SP4:                  
    SP5:                  


    ECgene alternative splicing isoforms for TIAL1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TIAL1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    TIAL1 Expression
    About this image

    TIAL1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TIAL1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.501203
        Pathway & Disease-focused RT2 Profiler PCR Array including TIAL1: 
              Apoptosis 384HT in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for TIAL1
    OriGene qSTAR qPCR primer pairs in human, mouse for TIAL1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TIAL1
    QuantiTect SYBR Green Assays in human, mouse, rat TIAL1
    QuantiFast Probe-based Assays in human, mouse, rat TIAL1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TIAL1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for TIAL1 gene from Selected species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tial11 , 5 Tia1 cytotoxic granule-associated RNA binding protein-like more1, 5 94.81(n)1
    99.23(a)1
      7 (70.20 cM)5
    218431  NM_009383.21  NP_033409.11 
     1284397775 
    chicken
    (Gallus gallus)
    Aves TIA11 TIA1 cytotoxic granule-associated RNA binding protein 87.89(n)
    95.1(a)
      771327  NM_204356.1  NP_989687.1 
    lizard
    (Anolis carolinensis)
    Reptilia TIAL16
    TIA1 cytotoxic granule-associated RNA binding prot...
    92(a)
    1 ↔ 1
    3(66341540-66368928)
    African clawed frog
    (Xenopus laevis)
    Amphibia tial1-A-prov2 TIA1 cytotoxic granule-associated RNA binding protein-like more 82.28(n)    AJ416631.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc661302 similar to TIA1 cytotoxic granule-associated RNA binding more 79.22(n)   394107  BC055501.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG47873
    Rox81
    RNA binding3
    Rox81
    62(a)3
    55.84(n)1
    55.47(a)1
      98C23
    428481  NM_170119.21  NP_732945.11 
    worm
    (Caenorhabditis elegans)
    Secernentea C18A3.5a3 RNA binding protein 51(a)
    (best of 4)
      II(5712808-5714773)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes PUB16
    Poly (A)+ RNA-binding protein, abundant mRNP-compo...
    26(a)
    1 → many
    XIV(602907-604268) YNL016W
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons UBP1B1 UBP1B 52.01(n)
    43.61(a)
      838309  NM_101598.2  NP_564018.1 
    rice
    (Oryza sativa)
    Liliopsida Os11g06201001 Os11g0620100 53.14(n)
    45.76(a)
      4350940  NM_001074824.1  NP_001068292.1 


    ENSEMBL Gene Tree for TIAL1 (if available)
    TreeFam Gene Tree for TIAL1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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    Paralogs for TIAL1 gene
    TIA12  RBM422  
    Selected SIMAP similar genes for TIAL1 using alignment to 6 protein entries:     TIAR_HUMAN (see all proteins) (see all similar genes):
    TIA1    CIRBP    RBMY1A1    RBM23    CSTF2    RALY
    CELF3    ELAVL2    ELAVL4    PABPC3    PABPC4    ELAVL1
    HNRPR    RBM7    PUF60    SYNCRIP    PABPC1    PABPC1L

    TIAL1 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for TIAL1
    PGOHUM00000243189


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

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    Selected SNPs for TIAL1 (see all 501)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs111990341,2
    --114979870(+) agaaaA/Gaaaga 2 -- int1 trp30--------
    rs107123461,2
    C--121332691(+) TGAAA-/CCCCCA 2 -- ds50012Minor allele frequency- C:0.25NA 4
    rs579060921,2
    C--121334119(+) AAAAA-/A/AA  
            
    CAAAA
    4 -- ut311NA 2
    rs352967851,2
    C,F--121335715(+) AAAAGA/-AAAAA 2 -- int13Minor allele frequency- -:0.50NA 6
    rs2018767281,2
    C--121335734(-) ACTGGC/TCNNNN 2 -- int10--------
    rs105415951,2
    C--121337737(+) aaaaa-/A/A   
      A
    /AAAA
    aaaaa
    2 -- int11NA 2
    rs345462811,2
    C--121343684(+) GCACGG/-TGCAT 2 -- int11Minor allele frequency- -:0.50NA 2
    rs348868641,2
    C--121343896(+) AAAGT-/AAAAAA 2 -- int11Minor allele frequency- A:0.00NA 2
    rs1125697611,2
    C,F--121344200(+) GCTGGG/ATGTGG 2 -- int11Minor allele frequency- A:0.50WA 2
    rs115983481,2
    H--121344461(+) aaaatA/Ccaaaa 2 -- int10--------

    HapMap Linkage Disequilibrium report for TIAL1 (121332977 - 121356541 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for TIAL1: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TIAL1
    DNA2.0 Custom Variant and Variant Library Synthesis for TIAL1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 603413    OMIM disorders: --

    Selected diseases for TIAL1 (see all 23):    
    About MalaCards
    west nile virus    spinal muscular atrophy    rheumatic disease    muscular atrophy
    neurofibromatosis    brain cancer    lateral sclerosis    amyotrophic lateral sclerosis
    herpes simplex    inflammatory bowel disease    ischemia    systemic lupus erythematosus
    lupus erythematosus    cerebritis    retinitis    hypoxia
    schizophrenia    thyroiditis    endotheliitis    breast cancer


    TIAL1 for disorders           About GeneDecksing

    2 Novoseek inferred disease relationships for TIAL1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    necrosis 0 2 9890998 (1), 18438838 (1)
    tumors 0 3 15474296 (1), 9890998 (1), 18438838 (1)


    Export disorders for TIAL1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

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    PubMed articles for TIAL1 gene, integrated from 10 sources (see all 86):
    (articles sorted by number of sources associating them with TIAL1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and functional characterization of a TIA-1-related nucleolysin. (PubMed id 1326761)1, 2, 3, 9 Kawakami A....Anderson P. (Proc. Natl. Acad. Sci. U.S.A. 1992)
    2. DNA damage activates a spatially distinct late cytoplasmic cell-cycle checkpoint network controlled by MK2-mediated RNA stabilization. (PubMed id 20932473)1, 2 Reinhardt H.C....Yaffe M.B. (Mol. Cell 2010)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. TIA-1 or TIAR is required for DT40 cell viability. (PubMed id 12533540)1, 9 Le Guiner C....Breathnach R. (J. Biol. Chem. 2003)
    5. An alternative form of nucleolysin binds to a T-cluster DNA in the silencer element of platelet factor 4 gene. (PubMed id 9207209)1, 9 Doi T.... Imanishi T. (Biochem. Biophys. Res. Commun. 1997)
    6. U1 snRNP-dependent function of TIAR in the regulation of alternative RNA processing of the human calcitonin/CGRP pre-mRNA. (PubMed id 12917321)1, 9 Zhu H....Lou H. (Mol. Cell. Biol. 2003)
    7. The RNA-binding protein TIAR is translocated from the nucleus to the cytoplasm during Fas-mediated apoptotic cell death. (PubMed id 7533298)1, 9 Taupin J.L....Anderson P. (Proc. Natl. Acad. Sci. U.S.A. 1995)
    8. Elucidation of a C-rich signature motif in target mRNAs of RNA-binding protein TIAR. (PubMed id 17682065)1, 9 Kim H.S....Wilce J.A. (Mol. Cell. Biol. 2007)
    9. Individual RNA recognition motifs of TIA-1 and TIAR have different RNA binding specificities. (PubMed id 8576255)1, 9 Dember L.M....Anderson P. (J. Biol. Chem. 1996)
    10. Control of the ATP synthase beta subunit expression by RNA-binding proteins TIA-1, TIAR, and HuR. (PubMed id 16890199)1, 9 Izquierdo J.M. (Biochem. Biophys. Res. Commun. 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 7073 HGNC: 11804 AceView: TIAL1 Ensembl:ENSG00000151923 euGenes: HUgn7073
    ECgene: TIAL1 H-InvDB: TIAL1

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for TIAL1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for TIAL1 gene:
    Search GeneIP for patents involving TIAL1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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