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Aliases for TIAF1 Gene

Aliases for TIAF1 Gene

  • TGFB1-Induced Anti-Apoptotic Factor 1 2 3
  • 12 KDa TGF-Beta-1-Induced Antiapoptotic Factor 3 4
  • SPR210 3 6
  • MAJN 3 6
  • TGF-Beta-1-Induced Antiapoptotic Factor 1 3
  • Molecule Associated With Jak-3 N-Terminal 3
  • KIAA0216 6
  • MYSPDZ 6
  • MYO18A 6

External Ids for TIAF1 Gene

Previous GeneCards Identifiers for TIAF1 Gene

  • GC17P027417
  • GC15M096425
  • GC17M027252
  • GC17M027546
  • GC17U900088
  • GC17M024424
  • GC17M027401
  • GC17M023609

Summaries for TIAF1 Gene

GeneCards Summary for TIAF1 Gene

TIAF1 (TGFB1-Induced Anti-Apoptotic Factor 1) is a Protein Coding gene. Among its related pathways are Signaling by FGFR and Signaling by FGFR1 mutants.

UniProtKB/Swiss-Prot for TIAF1 Gene

  • Inhibits the cytotoxic effects of TNF-alpha and overexpressed TNF receptor adapters TRADD, FADD, and RIPK1. Involved in TGF-beta1 inhibition of IkappaB-alpha expression and suppression of TNF-mediated IkappaB-alpha degradation.

Gene Wiki entry for TIAF1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TIAF1 Gene

Genomics for TIAF1 Gene

Regulatory Elements for TIAF1 Gene

Genomic Location for TIAF1 Gene

Start:
29,073,521 bp from pter
End:
29,078,857 bp from pter
Size:
5,337 bases
Orientation:
Minus strand

Genomic View for TIAF1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TIAF1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TIAF1 Gene

Proteins for TIAF1 Gene

  • Protein details for TIAF1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95411-TIAF1_HUMAN
    Recommended name:
    TGFB1-induced anti-apoptotic factor 1
    Protein Accession:
    O95411
    Secondary Accessions:
    • A2RRE2
    • Q6PEG2

    Protein attributes for TIAF1 Gene

    Size:
    115 amino acids
    Molecular mass:
    12414 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TIAF1 Gene

Proteomics data for TIAF1 Gene at MOPED

Post-translational modifications for TIAF1 Gene

No Post-translational modifications

Other Protein References for TIAF1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TIAF1 Gene

Domains for TIAF1 Gene

Protein Domains for TIAF1 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for TIAF1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TIAF1: view

No data available for Gene Families and UniProtKB/Swiss-Prot for TIAF1 Gene

Function for TIAF1 Gene

Molecular function for TIAF1 Gene

UniProtKB/Swiss-Prot Function:
Inhibits the cytotoxic effects of TNF-alpha and overexpressed TNF receptor adapters TRADD, FADD, and RIPK1. Involved in TGF-beta1 inhibition of IkappaB-alpha expression and suppression of TNF-mediated IkappaB-alpha degradation.

Gene Ontology (GO) - Molecular Function for TIAF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with TIAF1: view

Phenotypes for TIAF1 Gene

GenomeRNAi human phenotypes for TIAF1:
genes like me logo Genes that share phenotypes with TIAF1: view

Animal Model Products

CRISPR Products

miRNA for TIAF1 Gene

miRTarBase miRNAs that target TIAF1

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TIAF1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for TIAF1 Gene

Localization for TIAF1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TIAF1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TIAF1 Gene COMPARTMENTS Subcellular localization image for TIAF1 gene
Compartment Confidence
nucleus 5
extracellular 2
cytosol 1

Gene Ontology (GO) - Cellular Components for TIAF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus NAS 9918798
genes like me logo Genes that share ontologies with TIAF1: view

Pathways for TIAF1 Gene

genes like me logo Genes that share pathways with TIAF1: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Apoptosis 384HT in human,mouse,rat

Gene Ontology (GO) - Biological Process for TIAF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process IEA --
GO:0007249 I-kappaB kinase/NF-kappaB signaling IDA 9918798
GO:0043066 negative regulation of apoptotic process IDA 9918798
genes like me logo Genes that share ontologies with TIAF1: view

Transcripts for TIAF1 Gene

mRNA/cDNA for TIAF1 Gene

(311) Selected AceView cDNA sequences:
(2) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TIAF1 Gene

TGFB1-induced anti-apoptotic factor 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TIAF1

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TIAF1 Gene

No ASD Table

Relevant External Links for TIAF1 Gene

GeneLoc Exon Structure for
TIAF1
ECgene alternative splicing isoforms for
TIAF1

Expression for TIAF1 Gene

mRNA expression in normal human tissues for TIAF1 Gene

SOURCE GeneReport for Unigene cluster for TIAF1 Gene Hs.743384

mRNA Expression by UniProt/SwissProt for TIAF1 Gene

O95411-TIAF1_HUMAN
Tissue specificity: Not detectable in normal kidney and liver. Up-regulated in chronic and acute allograft rejection: expressed in the inflammatory infiltrate and in tubular epithelial cells.
genes like me logo Genes that share expressions with TIAF1: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Expression partners for TIAF1 Gene

Orthologs for TIAF1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TIAF1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TIAF1 35
  • 99.71 (n)
  • 99.13 (a)
TIAF1 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia 11 16
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.15776 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.3080 35
zebrafish
(Danio rerio)
Actinopterygii wufb52c07 35
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ZIP1 38
Species with no ortholog for TIAF1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TIAF1 Gene

ENSEMBL:
Gene Tree for TIAF1 (if available)
TreeFam:
Gene Tree for TIAF1 (if available)

Paralogs for TIAF1 Gene

No data available for Paralogs for TIAF1 Gene

Variants for TIAF1 Gene

Structural Variations from Database of Genomic Variants (DGV) for TIAF1 Gene

Variant ID Type Subtype PubMed ID
nsv833408 CNV Loss 17160897
nsv908029 CNV Loss 21882294

Relevant External Links for TIAF1 Gene

HapMap Linkage Disequilibrium report
TIAF1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for TIAF1 Gene

Disorders for TIAF1 Gene

No disorders were found for TIAF1 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for TIAF1 Gene

Publications for TIAF1 Gene

  1. Cloning and characterization of a novel transforming growth factor- beta1-induced TIAF1 protein that inhibits tumor necrosis factor cytotoxicity. (PMID: 9918798) Chang N.-S. … Lee C. (Biochem. Biophys. Res. Commun. 1998) 2 3 4 23
  2. High expression of TIAF-1 in chronic kidney and liver allograft rejection and in activated T-helper cells. (PMID: 12829915) van der Leij J. … Poppema S. (Transplantation 2003) 3 4 23
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Alternative splice variants encoding unstable protein domains exist in the human brain. (PMID: 15491607) Homma K. … Nishikawa K. (J. Mol. Biol. 2004) 3
  5. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3

Products for TIAF1 Gene

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Apoptosis 384HT in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate TIAF1
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat
  • Predesigned siRNA for gene silencing in human,mouse,rat for TIAF1
  • Block miRNA regulation of TIAF1 using miScript Target Protectors

Sources for TIAF1 Gene

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