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Aliases for TIAF1 Gene

Aliases for TIAF1 Gene

  • TGFB1-Induced Anti-Apoptotic Factor 1 2 3 5
  • 12 KDa TGF-Beta-1-Induced Antiapoptotic Factor 3 4
  • TGF-Beta-1-Induced Antiapoptotic Factor 1 3
  • Molecule Associated With Jak-3 N-Terminal 3
  • SPR210 3
  • MAJN 3

External Ids for TIAF1 Gene

Previous GeneCards Identifiers for TIAF1 Gene

  • GC17P027417
  • GC15M096425
  • GC17M027252
  • GC17M027546
  • GC17U900088
  • GC17M024424
  • GC17M027401
  • GC17M023609

Summaries for TIAF1 Gene

GeneCards Summary for TIAF1 Gene

TIAF1 (TGFB1-Induced Anti-Apoptotic Factor 1) is a Protein Coding gene.

UniProtKB/Swiss-Prot for TIAF1 Gene

  • Inhibits the cytotoxic effects of TNF-alpha and overexpressed TNF receptor adapters TRADD, FADD, and RIPK1. Involved in TGF-beta1 inhibition of IkappaB-alpha expression and suppression of TNF-mediated IkappaB-alpha degradation.

Gene Wiki entry for TIAF1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TIAF1 Gene

Genomics for TIAF1 Gene

Regulatory Elements for TIAF1 Gene

Genomic Location for TIAF1 Gene

Chromosome:
17
Start:
29,073,521 bp from pter
End:
29,078,857 bp from pter
Size:
5,337 bases
Orientation:
Minus strand

Genomic View for TIAF1 Gene

Genes around TIAF1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TIAF1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TIAF1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TIAF1 Gene

Proteins for TIAF1 Gene

  • Protein details for TIAF1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95411-TIAF1_HUMAN
    Recommended name:
    TGFB1-induced anti-apoptotic factor 1
    Protein Accession:
    O95411
    Secondary Accessions:
    • A2RRE2
    • Q6PEG2

    Protein attributes for TIAF1 Gene

    Size:
    115 amino acids
    Molecular mass:
    12414 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TIAF1 Gene

Proteomics data for TIAF1 Gene at MOPED

Post-translational modifications for TIAF1 Gene

No Post-translational modifications

Other Protein References for TIAF1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TIAF1 Gene

Domains & Families for TIAF1 Gene

Protein Domains for TIAF1 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for TIAF1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TIAF1: view

No data available for Gene Families and UniProtKB/Swiss-Prot for TIAF1 Gene

Function for TIAF1 Gene

Molecular function for TIAF1 Gene

UniProtKB/Swiss-Prot Function:
Inhibits the cytotoxic effects of TNF-alpha and overexpressed TNF receptor adapters TRADD, FADD, and RIPK1. Involved in TGF-beta1 inhibition of IkappaB-alpha expression and suppression of TNF-mediated IkappaB-alpha degradation.
genes like me logo Genes that share phenotypes with TIAF1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TIAF1 Gene

Localization for TIAF1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TIAF1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TIAF1 Gene COMPARTMENTS Subcellular localization image for TIAF1 gene
Compartment Confidence
nucleus 5
extracellular 2
cytosol 1

No data available for Gene Ontology (GO) - Cellular Components for TIAF1 Gene

Pathways & Interactions for TIAF1 Gene

SuperPathways for TIAF1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TIAF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007249 I-kappaB kinase/NF-kappaB signaling IDA 9918798
genes like me logo Genes that share ontologies with TIAF1: view

No data available for Pathways by source and SIGNOR curated interactions for TIAF1 Gene

Drugs & Compounds for TIAF1 Gene

No Compound Related Data Available

Transcripts for TIAF1 Gene

mRNA/cDNA for TIAF1 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(311) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TIAF1 Gene

TGFB1-induced anti-apoptotic factor 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TIAF1 Gene

No ASD Table

Relevant External Links for TIAF1 Gene

GeneLoc Exon Structure for
TIAF1
ECgene alternative splicing isoforms for
TIAF1

Expression for TIAF1 Gene

mRNA expression in normal human tissues for TIAF1 Gene

SOURCE GeneReport for Unigene cluster for TIAF1 Gene Hs.743384

mRNA Expression by UniProt/SwissProt for TIAF1 Gene

O95411-TIAF1_HUMAN
Tissue specificity: Not detectable in normal kidney and liver. Up-regulated in chronic and acute allograft rejection: expressed in the inflammatory infiltrate and in tubular epithelial cells.
genes like me logo Genes that share expression patterns with TIAF1: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for TIAF1 Gene

Orthologs for TIAF1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TIAF1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TIAF1 35
  • 99.71 (n)
  • 99.13 (a)
TIAF1 36
  • 99 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.15776 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.3080 35
zebrafish
(Danio rerio)
Actinopterygii wufb52c07 35
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ZIP1 38
Species with no ortholog for TIAF1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TIAF1 Gene

ENSEMBL:
Gene Tree for TIAF1 (if available)
TreeFam:
Gene Tree for TIAF1 (if available)

Paralogs for TIAF1 Gene

No data available for Paralogs for TIAF1 Gene

Variants for TIAF1 Gene

Structural Variations from Database of Genomic Variants (DGV) for TIAF1 Gene

Variant ID Type Subtype PubMed ID
nsv833408 CNV Loss 17160897
nsv908029 CNV Loss 21882294

Variation tolerance for TIAF1 Gene

Residual Variation Intolerance Score: 73.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.27; 25.27% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TIAF1 Gene

HapMap Linkage Disequilibrium report
TIAF1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for TIAF1 Gene

Disorders for TIAF1 Gene

Relevant External Links for TIAF1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TIAF1

No disorders were found for TIAF1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TIAF1 Gene

Publications for TIAF1 Gene

  1. Cloning and characterization of a novel transforming growth factor- beta1-induced TIAF1 protein that inhibits tumor necrosis factor cytotoxicity. (PMID: 9918798) Chang N.-S. … Lee C. (Biochem. Biophys. Res. Commun. 1998) 2 3 4 23 67
  2. High expression of TIAF-1 in chronic kidney and liver allograft rejection and in activated T-helper cells. (PMID: 12829915) van der Leij J. … Poppema S. (Transplantation 2003) 3 23
  3. TIAF1 self-aggregation in peritumor capsule formation, spontaneous activation of SMAD-responsive promoter in p53-deficient environment, and cell death. (PMID: 22534828) Chang J.Y. … Chang N.S. (Cell Death Dis 2012) 3
  4. TGF-I^ induces TIAF1 self-aggregation via type II receptor-independent signaling that leads to generation of amyloid I^ plaques in Alzheimer's disease. (PMID: 21368882) Lee M.H. … Chang N.S. (Cell Death Dis 2010) 3
  5. E3 ubiquitin ligase SIAH1 mediates ubiquitination and degradation of TRB3. (PMID: 18276110) Zhou Y. … He F. (Cell. Signal. 2008) 3

Products for TIAF1 Gene

Sources for TIAF1 Gene

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