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Aliases for TIAF1 Gene

Aliases for TIAF1 Gene

  • TGFB1-Induced Anti-Apoptotic Factor 1 2 3 5
  • 12 KDa TGF-Beta-1-Induced Antiapoptotic Factor 3 4
  • TGF-Beta-1-Induced Antiapoptotic Factor 1 3
  • Molecule Associated With Jak-3 N-Terminal 3
  • SPR210 3
  • MAJN 3

External Ids for TIAF1 Gene

Previous GeneCards Identifiers for TIAF1 Gene

  • GC17P027417
  • GC15M096425
  • GC17M027252
  • GC17M027546
  • GC17U900088
  • GC17M024424
  • GC17M027401
  • GC17M023609

Summaries for TIAF1 Gene

GeneCards Summary for TIAF1 Gene

TIAF1 (TGFB1-Induced Anti-Apoptotic Factor 1) is a Protein Coding gene.

UniProtKB/Swiss-Prot for TIAF1 Gene

  • Inhibits the cytotoxic effects of TNF-alpha and overexpressed TNF receptor adapters TRADD, FADD, and RIPK1. Involved in TGF-beta1 inhibition of IkappaB-alpha expression and suppression of TNF-mediated IkappaB-alpha degradation.

Gene Wiki entry for TIAF1 Gene

Additional gene information for TIAF1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TIAF1 Gene

Genomics for TIAF1 Gene

Regulatory Elements for TIAF1 Gene

Enhancers for TIAF1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17H029146 1.9 FANTOM5 Ensembl ENCODE dbSUPER 18.3 -70.8 -70847 6 HDGF PKNOX1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF207 ZNF143 MYO18A TIAF1 CRYBA1 ENSG00000264044 NEK8 PHF12 ENSG00000263709
GH17H029041 1.5 Ensembl ENCODE dbSUPER 21.1 +35.9 35863 2 MLX ZFP64 FEZF1 DMAP1 GLI4 YY1 ETS1 GLIS2 ZNF143 SP3 ENSG00000264044 TIAF1 SUPT6H PHF12 MYO18A SEZ6 SGK494 TMEM199 ERAL1 ENSG00000267259
GH17H029037 1.5 FANTOM5 Ensembl ENCODE dbSUPER 20.6 +39.4 39440 4 PKNOX1 ZNF175 CEBPG ZNF121 ZFHX2 GATA3 POLR2A ATF7 RCOR1 TRIM24 TIAF1 MYO18A SEZ6 TAOK1 NDUFS5P7
GH17H029045 1.2 ENCODE dbSUPER 21.2 +32.7 32686 1 ELF3 FOXA2 ARID4B RAD21 RARA YY1 ATF7 CREM MIXL1 EGR2 TIAF1 MYO18A NDUFS5P7
GH17H029047 1.1 Ensembl ENCODE dbSUPER 21.1 +29.8 29784 2 PKNOX1 GATA3 POLR2A SIN3A FOS RCOR1 FOXP2 DPF2 ZBTB20 MYO18A TIAF1 NDUFS5P7
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TIAF1 on UCSC Golden Path with GeneCards custom track

Genomic Location for TIAF1 Gene

Chromosome:
17
Start:
29,073,521 bp from pter
End:
29,078,857 bp from pter
Size:
5,337 bases
Orientation:
Minus strand

Genomic View for TIAF1 Gene

Genes around TIAF1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TIAF1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TIAF1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TIAF1 Gene

Proteins for TIAF1 Gene

  • Protein details for TIAF1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95411-TIAF1_HUMAN
    Recommended name:
    TGFB1-induced anti-apoptotic factor 1
    Protein Accession:
    O95411
    Secondary Accessions:
    • A2RRE2
    • Q6PEG2

    Protein attributes for TIAF1 Gene

    Size:
    115 amino acids
    Molecular mass:
    12414 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TIAF1 Gene

Post-translational modifications for TIAF1 Gene

No Post-translational modifications

Other Protein References for TIAF1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TIAF1 Gene

Domains & Families for TIAF1 Gene

Gene Families for TIAF1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for TIAF1 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for TIAF1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TIAF1: view

No data available for UniProtKB/Swiss-Prot for TIAF1 Gene

Function for TIAF1 Gene

Molecular function for TIAF1 Gene

UniProtKB/Swiss-Prot Function:
Inhibits the cytotoxic effects of TNF-alpha and overexpressed TNF receptor adapters TRADD, FADD, and RIPK1. Involved in TGF-beta1 inhibition of IkappaB-alpha expression and suppression of TNF-mediated IkappaB-alpha degradation.

Phenotypes From GWAS Catalog for TIAF1 Gene

Gene Ontology (GO) - Molecular Function for TIAF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with TIAF1: view
genes like me logo Genes that share phenotypes with TIAF1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for TIAF1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TIAF1 Gene

Localization for TIAF1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TIAF1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TIAF1 gene
Compartment Confidence
nucleus 5
extracellular 2
cytosol 1

Gene Ontology (GO) - Cellular Components for TIAF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus NAS 9918798
genes like me logo Genes that share ontologies with TIAF1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TIAF1 Gene

Pathways & Interactions for TIAF1 Gene

SuperPathways for TIAF1 Gene

No Data Available

Interacting Proteins for TIAF1 Gene

Gene Ontology (GO) - Biological Process for TIAF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process IEA --
GO:0007249 I-kappaB kinase/NF-kappaB signaling IDA 9918798
GO:0043066 negative regulation of apoptotic process IDA 9918798
genes like me logo Genes that share ontologies with TIAF1: view

No data available for Pathways by source and SIGNOR curated interactions for TIAF1 Gene

Drugs & Compounds for TIAF1 Gene

No Compound Related Data Available

Transcripts for TIAF1 Gene

mRNA/cDNA for TIAF1 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(311) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TIAF1 Gene

TGFB1-induced anti-apoptotic factor 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for TIAF1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for TIAF1 Gene

No ASD Table

Relevant External Links for TIAF1 Gene

GeneLoc Exon Structure for
TIAF1
ECgene alternative splicing isoforms for
TIAF1

Expression for TIAF1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TIAF1 Gene

NURSA nuclear receptor signaling pathways regulating expression of TIAF1 Gene:

TIAF1

SOURCE GeneReport for Unigene cluster for TIAF1 Gene:

Hs.743384

mRNA Expression by UniProt/SwissProt for TIAF1 Gene:

O95411-TIAF1_HUMAN
Tissue specificity: Not detectable in normal kidney and liver. Up-regulated in chronic and acute allograft rejection: expressed in the inflammatory infiltrate and in tubular epithelial cells.

Evidence on tissue expression from TISSUES for TIAF1 Gene

  • Skin(4.1)
  • Muscle(2.4)
genes like me logo Genes that share expression patterns with TIAF1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for TIAF1 Gene

Orthologs for TIAF1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TIAF1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TIAF1 33 34
  • 99.71 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.15776 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.3080 33
zebrafish
(Danio rerio)
Actinopterygii wufb52c07 33
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ZIP1 36
Species where no ortholog for TIAF1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TIAF1 Gene

ENSEMBL:
Gene Tree for TIAF1 (if available)
TreeFam:
Gene Tree for TIAF1 (if available)

Paralogs for TIAF1 Gene

No data available for Paralogs for TIAF1 Gene

Variants for TIAF1 Gene

Sequence variations from dbSNP and Humsavar for TIAF1 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1000373849 -- 29,077,331(+) TCACA(A/G)GCCAG intron-variant, upstream-variant-2KB
rs1002238953 -- 29,073,213(+) TGGAG(A/G)CTAGG downstream-variant-500B
rs1003888717 -- 29,077,086(+) AAGAC(A/G)CTGGG intron-variant, upstream-variant-2KB
rs1004192093 -- 29,073,536(+) AGGGC(A/C)TTTAT utr-variant-3-prime
rs1006264250 -- 29,074,714(+) GGAGA(A/G)GTGCC utr-variant-3-prime, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for TIAF1 Gene

Variant ID Type Subtype PubMed ID
nsv833408 CNV loss 17160897

Variation tolerance for TIAF1 Gene

Residual Variation Intolerance Score: 73.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.27; 25.27% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TIAF1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TIAF1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TIAF1 Gene

Disorders for TIAF1 Gene

Relevant External Links for TIAF1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TIAF1

No disorders were found for TIAF1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TIAF1 Gene

Publications for TIAF1 Gene

  1. Cloning and characterization of a novel transforming growth factor-beta1-induced TIAF1 protein that inhibits tumor necrosis factor cytotoxicity. (PMID: 9918798) Chang NS … Lee C (Biochemical and biophysical research communications 1998) 2 3 4 22 60
  2. High expression of TIAF-1 in chronic kidney and liver allograft rejection and in activated T-helper cells. (PMID: 12829915) van der Leij J … Poppema S (Transplantation 2003) 3 4 22 60
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  4. TIAF1 self-aggregation in peritumor capsule formation, spontaneous activation of SMAD-responsive promoter in p53-deficient environment, and cell death. (PMID: 22534828) Chang JY … Chang NS (Cell death & disease 2012) 3 60
  5. TGF-β induces TIAF1 self-aggregation via type II receptor-independent signaling that leads to generation of amyloid β plaques in Alzheimer's disease. (PMID: 21368882) Lee MH … Chang NS (Cell death & disease 2010) 3 60

Products for TIAF1 Gene

Sources for TIAF1 Gene

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