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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

TIA1 Gene

protein-coding GIFtS: 55
GCID: GC02M070437

TIA1 cytotoxic granule-associated RNA binding protein

(Previous name: TIA1 cytotoxic granule-associated RNA-binding protein )

Explore 49 diseases affiliated with
TIA1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
TIA1 Cytotoxic Granule-Associated RNA Binding Protein¹ ²		Nucleolysin TIA-1 Isoform P40²
TIA-1² ³		P40-TIA-1 (Containing P15-TIA-1)²
T-Cell-Restricted Intracellular Antigen-1² ³		P40-TIA-1¹
TIA1 Cytotoxic Granule-Associated RNA-Binding Protein¹		RNA-Binding Protein TIA-1³

External Ids:	HGNC: 11802¹	Entrez Gene: 7072²	Ensembl: ENSG00000116001⁷	OMIM: 603518⁵	UniProtKB: P31483³

Export aliases for TIA1 gene to outside databases

Previous GC identifers: GC02M070448 GC02M070649 GC02M070396 GC02M070413 GC02M070350 GC02M070292 GC02M070173

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TIA1:

The product encoded by this gene is a member of a RNA-binding protein family and possesses nucleolytic activity against

cytotoxic lymphocyte (CTL) target cells. It has been suggested that this protein may be involved in the induction of

apoptosis as it preferentially recognizes poly(A) homopolymers and induces DNA fragmentation in CTL targets. The major

granule-associated species is a 15-kDa protein that is thought to be derived from the carboxyl terminus of the 40-kDa

product by proteolytic processing. Alternative splicing resulting in different isoforms of this gene product has been

described in the literature. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: TIA1_HUMAN, P31483

Function: Involved in alternative pre-RNA splicing and regulation of mRNA translation by binding to AU-rich elements

(AREs) located in mRNA 3' untranslated regions (3' UTRs). Possesses nucleolytic activity against cytotoxic lymphocyte

target cells. May be involved in apoptosis

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000002.11 NC_018913.1 NT_022184.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the TIA1 gene promoter:
Sox5 Pax-5 POU3F2 (N-Oct-5a) POU3F2 (N-Oct-5b) POU3F2 HEN1 FOXJ2 (long isoform) POU2F1a FOXJ2 LyF-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): TIA1 promoter sequence

Search SABiosciences Chromatin IP Primers for TIA1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TIA1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p13 Ensembl cytogenetic band: 2p13.3 HGNC cytogenetic band: 2p13

TIA1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TIA1 gene location

GeneLoc information about chromosome 2 GeneLoc Exon Structure

GeneLoc location for GC02M070437: view genomic region (about GC identifiers)

Start:	70,436,576 bp from pter	End:	70,475,792 bp from pter
Size:	39,217 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: TIA1_HUMAN, P31483 (See protein sequence)

Recommended Name: Nucleolysin TIA-1 isoform p40

Size: 386 amino acids; 42963 Da

Subcellular location: Cytoplasmic granule. Nucleus. Note=Accumulates in cytoplasmic stress granules (SG) following

cellular damage

1 PDB 3D structure from and Proteopedia for TIA1:

3BS9 (3D)

Secondary accessions: Q53SS9

Alternative splicing: 2 isoforms: P31483-1 P31483-2

Explore the universe of human proteins at neXtProt for TIA1: NX_P31483

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P31483

TIA1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_071320.2 NP_071505.2

ENSEMBL proteins:

ENSP00000401371 ENSP00000404023 ENSP00000282574 ENSP00000399567 ENSP00000402263

ENSP00000413751 ENSP00000430969 ENSP00000427794 ENSP00000354838

Human Recombinant Protein Products:

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	Novus Biologicals TIA1 Protein Novus Biologicals TIA1 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for TIA1

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--
GO:0005737	cytoplasm	--	--
GO:0010494	cytoplasmic stress granule	IEA	--

TIA1 for ontologies About GeneDecksing

TIA1 Antibody Products:

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	Uscn ELISAs and CLIAs for TIA1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

TIA1 for domains About GeneDecksing

2 InterPro domains/families:

IPR000504 RRM_dom

IPR012677 Nucleotide-bd_a/b_plait

Graphical View of Domain Structure for InterPro Entry P31483

ProtoNet protein and cluster: P31483

1 Blocks protein family: IPB000504 RNA-binding region RNP-1 (RNA recognition motif)

UniProtKB/Swiss-Prot: TIA1_HUMAN, P31483

Similarity: Contains 3 RRM (RNA recognition motif) domains

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: TIA1_HUMAN, P31483

Function: Involved in alternative pre-RNA splicing and regulation of mRNA translation by binding to AU-rich elements

(AREs) located in mRNA 3' untranslated regions (3' UTRs). Possesses nucleolytic activity against cytotoxic lymphocyte

target cells. May be involved in apoptosis

Genatlas biochemistry entry for TIA1:

cytotoxic granule associated RNA binding protein,p40-TIA1,40 kDa,expressed only in cytotoxic lymphocytes

(CTL),precursor of 15 kDa (p15-TIA-1),major granule associated species

miRNA Products:		OriGene 3'-UTR Clone (see all 2): TIA1 Browse MicroRNA Expression Plasmids
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		8/126 QIAGEN miScript miRNA Assays for microRNAs that regulate TIA1 (see all 126):
		hsa-miR-199a-3p hsa-miR-128 hsa-miR-30d hsa-miR-342-3p hsa-miR-1304 hsa-miR-3161 hsa-miR-30a hsa-miR-4325

		SwitchGear 3'UTR luciferase reporter plasmid: TIA1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TIA1 (see all 7) OriGene shRNA RFP: TIA1 OriGene siRNA: TIA1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TIA1

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for TIA1

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for TIA1
		Search LifeMap BioReagents cell lines for TIA1

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TIA1

Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000166	nucleotide binding	IEA	--
GO:0003676	nucleic acid binding	--	--
GO:0005515	protein binding	IPI	7544399
GO:0008143	poly(A) RNA binding	TAS	1934064
GO:0017091	AU-rich element binding	IEA	--

TIA1 for ontologies           About GeneDecksing

Animal Models:
     Mouse knock-out Tia1^tm1Andp for TIA1
     5 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Tia1):

growth/size

hematopoietic system

immune system

mortality/aging

skeleton

TIA1 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

IL-10 Pathway

IL-10 Pathway

1.00

1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for TIA1

IL-10 Pathway

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for TIA1

STRING Interaction Network Preview (showing 5 interactants - click image to see 14)

5/45 Interacting proteins for TIA1 (P31483^{2, 3} ENSP00000401371⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 45)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
RC3H2	Q9HBD1²^,³, ENSP00000349783⁴	MINT-7711447 MINT-7711460 I2D: score=1 STRING: ENSP00000349783
HABP4	Q5JVS0²^,³, ENSP00000364398⁴	MINT-8194441 I2D: score=1 STRING: ENSP00000364398
DCP1A	Q9NPI6²^,³	MINT-7711192 I2D: score=1
SND1	Q7KZF4²^,³, ENSP00000346762⁴	MINT-7968800 I2D: score=1 STRING: ENSP00000346762
SRSF1	Q07955³, ENSP00000258962⁴	I2D: score=1 STRING: ENSP00000258962

About this table

Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006915	apoptotic process	IEA	--
GO:0006917	induction of apoptosis	TAS	1934064
GO:0017148	negative regulation of translation	IEA	--
GO:0042036	negative regulation of cytokine biosynthetic process	IEA	--
GO:0048024	regulation of mRNA splicing, via spliceosome	IDA	11106748

TIA1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

TIA1 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for TIA1
9 Novoseek chemical compound relationships for TIA1 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
[alcl]	65.5	10	10029454 (4), 10396241 (2)
paraffin	47.9	10	10414505 (2), 11756181 (1), 15660281 (1), 12475440 (1) (see all 9)
arsenite	43.7	3	17626845 (1), 16982678 (1)
serine	20.3	6	8176212 (1), 17135269 (1), 8104216 (1), 7544399 (1) (see all 5)
threonine	14.2	2	17135269 (1), 7544399 (1)
prednisolone	4.54	1	12956685 (1)
atp	0	5	16890199 (1), 17466948 (1)
adenylate	0	2	11121440 (1), 8759725 (1)
adenine	0	2	17599736 (1), 16581801 (1)

Search CenterWatch for drugs/clinical trials and news about TIA1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for TIA1 gene (2 alternative transcripts):

NM_022037.2 NM_022173.2

Unigene Cluster for TIA1:

TIA1 cytotoxic granule-associated RNA binding protein

Hs.516075 [show with all ESTs]

Unigene Representative Sequence: AB209211

18/20 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 20):

ENST00000433529(uc002sgj.4 uc002sgl.4) ENST00000415783(uc002sgk.4)

ENST00000282574 ENST00000445587 ENST00000486392 ENST00000495774 ENST00000454815

ENST00000468787 ENST00000482876 ENST00000497672 ENST00000477415 ENST00000496096

ENST00000484065 ENST00000416149 ENST00000474699 ENST00000474809(uc002sgm.3)

ENST00000477044 ENST00000361692

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		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TIA1
		8/126 QIAGEN miScript miRNA Assays for microRNAs that regulate TIA1 (see all 126):
		hsa-miR-199a-3p hsa-miR-128 hsa-miR-30d hsa-miR-342-3p hsa-miR-1304 hsa-miR-3161 hsa-miR-30a hsa-miR-4325

		SwitchGear 3'UTR luciferase reporter plasmid: TIA1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TIA1 (see all 7) OriGene shRNA RFP: TIA1 OriGene siRNA: TIA1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TIA1

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TIA1 (see all 7) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TIA1 (see all 3) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): TIA1 (NM_022173)
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		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TIA1

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TIA1

Additional cDNA sequence:

AB209211.1 AF090093.1 AK093744.1 AK303345.1 BC015944.1 M77142.1

24/28 DOTS entries (see all 28):

DT.95122173 DT.95082382 DT.100791104 DT.87077948 DT.92439302 DT.444289 DT.100791110 DT.40110131

DT.206004 DT.100738048 DT.100791105 DT.120959510 DT.86845350 DT.100852947 DT.100791111 DT.100674885

DT.100791107 DT.120959559 DT.40107771 DT.91966244 DT.92045397 DT.92439310 DT.95122183 DT.99939529

24/364 AceView cDNA sequences (see all 364):

CA429517 BU620487 AA779686 CA391318 AI440220 BI438724 BC015944 AW614841

AA485194 AI619711 BQ937619 D60230 BM977942 BE351014 F08710 BM711447

BQ879464 AI923856 AU131849 BM801053 AA479542 CR607569 AA649204 AA600357

GeneLoc Exon Structure

5/11 Alternative Splicing Database (ASD) splice patterns (SP) for TIA1 (see all 11) About this scheme

ExUns:	1a	·	1b	·	1c	·	1d	·	1e	·	1f	^	2a	·	2b	^	3	^	4a	·	4b	^	5a	·	5b	^	6	^	7	^	8a	·	8b	·	8c	^	9a	·	9b	·	9c	^	10a	·	10b	^	11a	·	11b	^	12a	·
SP1:																					-				-				-		-										-
SP2:																					-		-		-				-		-								-		-
SP3:																					-				-				-		-								-		-
SP4:																					-				-				-		-								-		-
SP5:																					-				-				-		-

ExUns:	12b	^	13	^	14a	·	14b	^	15a	·	15b	·	15c
SP1:			-
SP2:			-
SP3:
SP4:
SP5:

ECgene alternative splicing isoforms for TIA1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TIA1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGAAAATCAA

About this image

TIA1 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Head Mesenchyme

Branchial Arch 1

Paraxial Mesoderm Cells

Bone, Skeletal Muscle

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See TIA1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TIA1

SOURCE GeneReport for Unigene cluster: Hs.516075

SABiosciences Expression via Pathway-Focused PCR Array including TIA1:

Apoptosis 384HT in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TIA1 Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TIA1

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TIA1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for TIA1 gene from 7/24 species (see all 24) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	TIA1¹	TIA1 cytotoxic granule-associated RNA binding protein	84.07(n) 96.08(a)		771327 XM_003642555.1 XP_003642603.1
tropical clawed frog (Xenopus tropicalis)	Amphibia	BC064164.1²	--	80.28(n)		BC064164.1
zebrafish (Danio rerio)	Actinopterygii	Dr.4576²	Danio rerio mRNA similar to TIA1 cytotoxic granule-associated more	77.02(n)		BC045368.1
fruit fly (Drosophila melanogaster)	Insecta	CG4787³	RNA binding	61(a)		98C2 --
worm (Caenorhabditis elegans)	Secernentea	C18A3.5a³	RNA binding protein	51(a) (best of 4)		II(5712808-5714773) --
thale cress (Arabidopsis thaliana)	eudicotyledons	PAB7⁶ PAB6⁶ (see all 13)	poly(A) binding protein 6 (see all 13)	8(a) 8(a) (see all 13)	possible ortholog possible ortholog (see all 13)	2(15361321-15364398) 3(5558676-5560993)
rice (Oryza sativa)	Liliopsida	Os07g0615400¹	hypothetical protein	52.01(n) 42.86(a)		4343900 NM_001066804.1 NP_001060269.1

ENSEMBL Gene Tree for TIA1 (if available)
TreeFam Gene Tree for TIA1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for TIA1 gene

TIAL1²

10 SIMAP similar genes for TIA1 using alignment to 9 protein entries: TIA1_HUMAN (see all proteins):

TIAL1 SF3B4 RBMY1A1 ELAVL2 HNRNPA1 PABPC3

PABPC1 PABPC4 RBM4B RBM38

TIA1 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 2 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs111770748^1,2	C,	--	70172989(+)	`CAAGAC/TCAGCC`	2	--	ds500¹		1		WA	2
rs113037684^1,2		--	70173024(+)	`TGTACT/CGAAAA`	2	--	ds500¹		2		CSA WA	120
rs78267475^1,2	C,	--	70173574(+)	`TGCTCA/GTGCTT`	2	--	ut3¹		3		WA CSA	121
rs75842076^1,2	F,	--	70173891(+)	`ATTTTC/TAACAA`	2	--	ut3¹		1		NA	120
rs74320214^1,2		--	70174185(+)	`GTAAAC/TCACTT`	2	--	ut3¹		0	--	--	--	--
rs11949^1,2	C,F,H,	--	70174812(+)	`ATGAAA/GTATCA`	2	--	ut3¹		9		MN NS EA WA	1388
rs10175751^1,2	C,F,H,	--	70175135(+)	`AGAGAC/TTCTGA`	2	--	ut3¹		7		NS EA NA WA	822
rs11454237^1,2	C,	--	70175322(+)	`TAAGGT/-TTTTT`	2	--	ut3¹		1		CSA	2
rs3207592^1,2	F	--	70176003(-)	`TTAAAT/AGGAAA`	2	--	ut3¹		1		MN	184
rs1059359^1,2	H	--	70176106(-)	`CCCTTT/GGGGGT`	2	--	ut3¹		5		NS EA NA	418

HapMap Linkage Disequilibrium report for TIA1 (70436576 - 70475792 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for TIA1: --

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

TIA1 for disorders           About GeneDecksing

OMIM gene information: 603518    OMIM disorders: --

20/49 diseases for TIA1 (see all 49):    About MalaCards

lymphomatoid papulosis enteropathy-associated t-cell lymphoma spinal muscular atrophy diffuse large b-cell lymphoma

mycosis fungoides b-cell lymphomas hemophagocytic lymphohistiocytosis anaplastic large cell lymphoma

non-hodgkin lymphoma composite lymphoma lichen sclerosus panniculitis

muscular atrophy hairy cell leukemia adenoid cystic carcinoma systemic lupus erythematosus

peripheral t-cell lymphoma reticulosarcoma lupus erythematosus hodgkin's lymphoma

4 diseases from the University of Copenhagen DISEASES database for TIA1:

Lymphoma Panniculitis Reticulosarcoma Hemophagocytic lymphohistiocytosis

10/26 Novoseek disease relationships for TIA1 gene (see all 26) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
lymphoma t-cell	83.9	10	12405910 (2), 11315625 (2), 19452707 (1), 9209634 (1) (see all 7)
lymphoma t-cell peripheral	81.5	3	8655683 (1), 10414505 (1), 16160469 (1)
lymphoma	69.6	37	9496260 (3), 11315625 (3), 14616965 (2), 10368677 (2) (see all 23)
lymphomatoid papulosis	61.2	2	10672058 (1), 10233858 (1)
lymphoid neoplasm	60	1	9176382 (1)
lymphoma large cell	59.2	1	15073603 (1)
panniculitis	55.6	2	12956685 (1)
lymphoproliferative disorders	50.2	1	10892713 (1)
hodgkin disease	50.1	3	9176382 (2), 20065852 (1)
subcutaneous nodule	47.3	1	12956685 (1)

Export disorders for TIA1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for TIA1 gene, integrated from 9 sources (see all 216):
(articles sorted by number of sources associating them with TIA1)

Utopia: connect your pdf to the dynamic
world of online information

Intron-exon organization and chromosomal localization of the human TIA-1 gene. (PubMed id 8176212)^{1, 2, 3, 9} Kawakami A....Anderson P. (1994)
Structure of the central RNA recognition motif of human TIA-1 at 1.95A resolution. (PubMed id 18201561)^{1, 2, 9} Kumar A.O....Kielkopf C.L. (2008)
The splicing regulator TIA-1 interacts with U1-C to promote U1 snRNP recruitment to 5' splice sites. (PubMed id 12486009)^{1, 3, 9} Forch P....Valcarcel J. (2002)
A polyadenylate binding protein localized to the granules of cytolytic lymphocytes induces DNA fragmentation in target cells. (PubMed id 1934064)^{1, 2, 9} Tian Q.... Anderson P. (1991)
An intronic polypyrimidine-rich element downstream of the donor site modulates cystic fibrosis transmembrane conductance regulator exon 9 alternative splicing. (PubMed id 14966131)^{1, 9} Zuccato E....Pagani F. (2004)
Effects of infliximab therapy on gene expression levels of tumor necrosis factor alpha, tristetraprolin, T cell intracellular antigen 1, and Hu antigen R in patients with rheumatoid arthritis. (PubMed id 17599736)^{1, 9} Sugihara M....Sumida T. (2007)
Identification and functional outcome of mRNAs associated with RNA-binding protein TIA-1. (PubMed id 16227602)^{1, 9} Lopez de Silanes I....Gorospe M. (2005)
Two isoforms of the T-cell intracellular antigen 1 (TIA-1) splicing factor display distinct splicing regulation activities. Control of TIA-1 isoform ratio by TIA-1-related protein. (PubMed id 17488725)^{1, 9} Izquierdo J.M. and Valcarcel J. (2007)
Regulation of cyclooxygenase-2 expression by the translational silencer TIA-1. (PubMed id 12885872)^{1, 9} Dixon D.A....Prescott S.M. (2003)
Individual RNA recognition motifs of TIA-1 and TIAR have different RNA binding specificities. (PubMed id 8576255)^{1, 9} Dember L.M....Anderson P. (1996)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 7072	HGNC: 11802	AceView: TIA1	Ensembl:ENSG00000116001	euGenes: HUgn7072
ECgene: TIA1	H-InvDB: TIA1

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for TIA1	Pharmacogenomics, SNPs, Pathways

Intellectual Property for TIA1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for TIA1 gene:
Search GeneIP for patents involving TIA1

GeneCards and IP:
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TIA1 cytotoxic granule-associated RNA binding protein

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TIA1 cytotoxic granule-associated RNA binding protein

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