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Aliases for TIA1 Gene

Aliases for TIA1 Gene

  • TIA1 Cytotoxic Granule-Associated RNA Binding Protein 2 3
  • T-Cell-Restricted Intracellular Antigen-1 2 3 4
  • Nucleolysin TIA-1 Isoform P40 2 3
  • TIA-1 3 4
  • WDM 3 6
  • TIA1 Cytotoxic Granule-Associated RNA-Binding Protein 2
  • P40-TIA-1 (Containing P15-TIA-1) 3
  • RNA-Binding Protein TIA-1 4
  • P40-TIA-1 4

External Ids for TIA1 Gene

Summaries for TIA1 Gene

Entrez Gene Summary for TIA1 Gene

  • The product encoded by this gene is a member of a RNA-binding protein family and possesses nucleolytic activity against cytotoxic lymphocyte (CTL) target cells. It has been suggested that this protein may be involved in the induction of apoptosis as it preferentially recognizes poly(A) homopolymers and induces DNA fragmentation in CTL targets. The major granule-associated species is a 15-kDa protein that is thought to be derived from the carboxyl terminus of the 40-kDa product by proteolytic processing. Alternative splicing resulting in different isoforms of this gene product has been described in the literature. [provided by RefSeq, Jul 2008]

GeneCards Summary for TIA1 Gene

TIA1 (TIA1 Cytotoxic Granule-Associated RNA Binding Protein) is a Protein Coding gene. Diseases associated with TIA1 include lymphomatoid papulosis and panniculitis. Among its related pathways are IL-10 Pathway. GO annotations related to this gene include nucleotide binding and poly(A) binding. An important paralog of this gene is TIAL1.

UniProtKB/Swiss-Prot for TIA1 Gene

  • Involved in alternative pre-RNA splicing and regulation of mRNA translation by binding to AU-rich elements (AREs) located in mRNA 3 untranslated regions (3 UTRs). Possesses nucleolytic activity against cytotoxic lymphocyte target cells. May be involved in apoptosis

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TIA1 Gene

Genomics for TIA1 Gene

Genomic Location for TIA1 Gene

70,209,444 bp from pter
70,248,744 bp from pter
39,301 bases
Minus strand

Genomic View for TIA1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TIA1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TIA1 Gene

Proteins for TIA1 Gene

  • Protein details for TIA1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Nucleolysin TIA-1 isoform p40
    Protein Accession:
    Secondary Accessions:
    • Q53SS9
    • Q96B58

    Protein attributes for TIA1 Gene

    386 amino acids
    Molecular mass:
    42963 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for TIA1 Gene

    Alternative splice isoforms for TIA1 Gene


neXtProt entry for TIA1 Gene

Proteomics data for TIA1 Gene at MOPED

Post-translational modifications for TIA1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TIA1 Gene

Domains for TIA1 Gene

Gene Families for TIA1 Gene

  • RBM :RNA binding motif (RRM) containing

Protein Domains for TIA1 Gene


  • Contains 3 RRM (RNA recognition motif) domains.:
    • P31483
genes like me logo Genes that share domains with TIA1: view

Function for TIA1 Gene

Molecular function for TIA1 Gene

GENATLAS Biochemistry: cytotoxic granule associated RNA binding protein,p40-TIA1,40 kDa,expressed only in cytotoxic lymphocytes (CTL),precursor of 15 kDa (p15-TIA-1),major granule associated species
UniProtKB/Swiss-Prot Function: Involved in alternative pre-RNA splicing and regulation of mRNA translation by binding to AU-rich elements (AREs) located in mRNA 3 untranslated regions (3 UTRs). Possesses nucleolytic activity against cytotoxic lymphocyte target cells. May be involved in apoptosis

Gene Ontology (GO) - Molecular Function for TIA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003676 nucleic acid binding --
GO:0005515 protein binding IPI 12486009
GO:0008143 poly(A) binding TAS 1934064
GO:0017091 AU-rich element binding IEA --
genes like me logo Genes that share ontologies with TIA1: view
genes like me logo Genes that share phenotypes with TIA1: view

Animal Models for TIA1 Gene

MGI Knock Outs for TIA1:

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for TIA1 Gene

Localization for TIA1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TIA1 Gene

Cytoplasmic granule. Nucleus. Note=Accumulates in cytoplasmic stress granules (SG) following cellular damage.

Subcellular locations from

Jensen Localization Image for TIA1 Gene COMPARTMENTS Subcellular localization image for TIA1 gene
Compartment Confidence
nucleus 5
lysosome 2
vacuole 2
cytosol 1
extracellular 1

Gene Ontology (GO) - Cellular Components for TIA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
GO:0010494 cytoplasmic stress granule IDA 21984414
GO:0097165 nuclear stress granule IDA 21984414
genes like me logo Genes that share ontologies with TIA1: view

Pathways for TIA1 Gene

SuperPathways for TIA1 Gene

Superpath Contained pathways
1 IL-10 Pathway
genes like me logo Genes that share pathways with TIA1: view

Pathways by source for TIA1 Gene

1 Qiagen pathway for TIA1 Gene

Gene Ontology (GO) - Biological Process for TIA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process IEA --
GO:0017148 negative regulation of translation IEA --
GO:0042036 negative regulation of cytokine biosynthetic process IEA --
GO:0048024 regulation of mRNA splicing, via spliceosome IDA 11106748
genes like me logo Genes that share ontologies with TIA1: view

Compounds for TIA1 Gene

(9) Novoseek inferred chemical compound relationships for TIA1 Gene

Compound -log(P) Hits PubMed IDs
[alcl] 65.5 6
paraffin 47.9 10
arsenite 43.7 2
serine 20.3 5
threonine 14.2 2
genes like me logo Genes that share compounds with TIA1: view

Transcripts for TIA1 Gene

Unigene Clusters for TIA1 Gene

TIA1 cytotoxic granule-associated RNA binding protein:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TIA1 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b · 9c ^ 10a · 10b ^ 11a · 11b ^ 12a ·
SP1: - - - - -
SP2: - - - - - - -
SP3: - - - - - -
SP4: - - - - - -
SP5: - - - -
SP6: - -
SP7: -
SP8: - -

ExUns: 12b ^ 13 ^ 14a · 14b ^ 15a · 15b · 15c
SP1: -
SP2: -
SP7: -

Relevant External Links for TIA1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TIA1 Gene

mRNA expression in normal human tissues for TIA1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TIA1 Gene

SOURCE GeneReport for Unigene cluster for TIA1 Gene Hs.413123

genes like me logo Genes that share expressions with TIA1: view

Orthologs for TIA1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TIA1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TIA1 36
  • 99.83 (n)
  • 100 (a)
TIA1 37
  • 100 (a)
(Bos Taurus)
Mammalia TIA1 36
  • 95.47 (n)
  • 97.91 (a)
TIA1 37
  • 98 (a)
(Canis familiaris)
Mammalia TIA1 36
  • 95.94 (n)
  • 98.96 (a)
TIA1 37
  • 94 (a)
(Mus musculus)
Mammalia Tia1 36
  • 91.97 (n)
  • 96.63 (a)
Tia1 16
Tia1 37
  • 97 (a)
(Monodelphis domestica)
Mammalia TIA1 37
  • 97 (a)
(Ornithorhynchus anatinus)
Mammalia TIA1 37
  • 82 (a)
(Rattus norvegicus)
Mammalia Tia1 36
  • 91.29 (n)
  • 96.27 (a)
(Gallus gallus)
Aves TIA1 37
  • 96 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia tia1 36
  • 79.74 (n)
  • 88.05 (a)
(Danio rerio)
Actinopterygii Dr.4576 36
tia1 36
  • 74.6 (n)
  • 85.56 (a)
tia1 37
  • 82 (a)
tia1l 37
  • 80 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG34354 37
  • 30 (a)
CG34362 37
  • 20 (a)
Rox8 37
  • 38 (a)
CG4787 38
  • 61 (a)
(Caenorhabditis elegans)
Secernentea tiar-1 37
  • 38 (a)
tiar-2 37
  • 33 (a)
tiar-3 37
  • 25 (a)
C07A4.1 38
  • 44 (a)
Y46G5A.13 38
  • 43 (a)
C18A3.5a 38
  • 51 (a)
C18A3.5b 38
  • 46 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGR390C 36
  • 41.86 (n)
  • 33.97 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PUB1 36
  • 47.71 (n)
  • 38.41 (a)
PUB1 37
  • 26 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E08779g 36
  • 46.35 (n)
  • 33.9 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU07874 36
  • 47.42 (n)
  • 41.03 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 31 (a)
CSA.8430 37
  • 52 (a)
Species with no ortholog for TIA1:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TIA1 Gene

Gene Tree for TIA1 (if available)
Gene Tree for TIA1 (if available)

Paralogs for TIA1 Gene

Paralogs for TIA1 Gene

genes like me logo Genes that share paralogs with TIA1: view

Variants for TIA1 Gene

Sequence variations from dbSNP and Humsavar for TIA1 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs11949 -- 70,210,910(+) ATGAA(A/G)TATCA utr-variant-3-prime, nc-transcript-variant
rs964392 -- 70,228,775(+) GCCCA(A/G)ATGGT intron-variant, utr-variant-5-prime
rs1004831 -- 70,242,423(+) GAACC(C/T)GGGAA intron-variant
rs1059359 -- 70,212,204(-) CCCTT(G/T)GGGGT utr-variant-3-prime, nc-transcript-variant
rs1059408 -- 70,209,686(-) AAATC(A/G)TCAAT utr-variant-3-prime, nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for TIA1 Gene

Variant ID Type Subtype PubMed ID
nsv518294 CNV Loss 19592680

Relevant External Links for TIA1 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

Disorders for TIA1 Gene

(1) OMIM Diseases for TIA1 Gene (603518)


  • Welander distal myopathy (WDM) [MIM:604454]: An autosomal dominant disorder characterized by adult onset of distal muscle weakness predominantly affecting the distal long extensors of the hands, with slow progression to involve all small hand muscles and the lower legs. Skeletal muscle biopsy shows myopathic changes and prominent rimmed vacuoles. Rare homozygous patients showed earlier onset, faster progression, and proximal muscle involvement. {ECO:0000269 PubMed:23348830, ECO:0000269 PubMed:23401021}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(3) University of Copenhagen DISEASES for TIA1 Gene

(26) Novoseek inferred disease relationships for TIA1 Gene

Disease -log(P) Hits PubMed IDs
lymphoma t-cell 83.9 9
lymphoma t-cell peripheral 81.5 3
lymphoma 69.6 31
lymphomatoid papulosis 61.2 2
lymphoid neoplasm 60 1
genes like me logo Genes that share disorders with TIA1: view

Publications for TIA1 Gene

  1. Intron-exon organization and chromosomal localization of the human TIA-1 gene. (PMID: 8176212) Kawakami A. … Anderson P. (J. Immunol. 1994) 2 3 4 23
  2. A polyadenylate binding protein localized to the granules of cytolytic lymphocytes induces DNA fragmentation in target cells. (PMID: 1934064) Tian Q. … Anderson P. (Cell 1991) 3 4 23
  3. The splicing regulator TIA-1 interacts with U1-C to promote U1 snRNP recruitment to 5' splice sites. (PMID: 12486009) FAPrch P. … ValcA!rcel J. (EMBO J. 2002) 2 3 23
  4. Structure of the central RNA recognition motif of human TIA-1 at 1.95A resolution. (PMID: 18201561) Kumar A.O. … Kielkopf C.L. (Biochem. Biophys. Res. Commun. 2008) 3 4 23
  5. A systematic analysis of intronic sequences downstream of 5' splice sites reveals a widespread role for U-rich motifs and TIA1/TIAL1 proteins in alternative splicing regulation. (PMID: 18456862) Aznarez I. … Blencowe B.J. (Genome Res. 2008) 3 23

Products for TIA1 Gene

Sources for TIA1 Gene

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