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Aliases for THYN1 Gene

Aliases for THYN1 Gene

  • Thymocyte Nuclear Protein 1 2 3
  • THY28 3 4 6
  • Thymocyte Protein Thy28 3 4
  • HSPC144 3 6
  • THY28KD 3
  • MDS012 3
  • MY105 3

External Ids for THYN1 Gene

Previous GeneCards Identifiers for THYN1 Gene

  • GC11M133624
  • GC11M134118
  • GC11M130072

Summaries for THYN1 Gene

Entrez Gene Summary for THYN1 Gene

  • This gene encodes a protein that is highly conserved among vertebrates and plant species and may be involved in the induction of apoptosis. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

GeneCards Summary for THYN1 Gene

THYN1 (Thymocyte Nuclear Protein 1) is a Protein Coding gene.

UniProtKB/Swiss-Prot for THYN1 Gene

  • Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC.

Gene Wiki entry for THYN1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for THYN1 Gene

Genomics for THYN1 Gene

Regulatory Elements for THYN1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for THYN1 Gene

Start:
134,248,278 bp from pter
End:
134,253,396 bp from pter
Size:
5,119 bases
Orientation:
Minus strand

Genomic View for THYN1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for THYN1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for THYN1 Gene

Proteins for THYN1 Gene

  • Protein details for THYN1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P016-THYN1_HUMAN
    Recommended name:
    Thymocyte nuclear protein 1
    Protein Accession:
    Q9P016
    Secondary Accessions:
    • Q567Q2
    • Q9H3L4
    • Q9HC20

    Protein attributes for THYN1 Gene

    Size:
    225 amino acids
    Molecular mass:
    25697 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for THYN1 Gene

    Alternative splice isoforms for THYN1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for THYN1 Gene

Proteomics data for THYN1 Gene at MOPED

Post-translational modifications for THYN1 Gene

Other Protein References for THYN1 Gene

No data available for DME Specific Peptides for THYN1 Gene

Domains for THYN1 Gene

Protein Domains for THYN1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for THYN1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with THYN1: view

No data available for Gene Families and UniProtKB/Swiss-Prot for THYN1 Gene

Function for THYN1 Gene

Molecular function for THYN1 Gene

UniProtKB/Swiss-Prot Function: Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC.

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for THYN1 Gene

Localization for THYN1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for THYN1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for THYN1 Gene COMPARTMENTS Subcellular localization image for THYN1 gene
Compartment Confidence
nucleus 3
mitochondrion 1

Gene Ontology (GO) - Cellular Components for THYN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS 14601557
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with THYN1: view

Pathways for THYN1 Gene

SuperPathways for THYN1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for THYN1 Gene

None

No data available for Pathways by source for THYN1 Gene

Transcripts for THYN1 Gene

Unigene Clusters for THYN1 Gene

Thymocyte nuclear protein 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for THYN1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for THYN1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9
SP1: - - - - - -
SP2: - - - - -
SP3: - - - - - -
SP4: - - -
SP5: - - - -
SP6: - -
SP7:
SP8:

Relevant External Links for THYN1 Gene

GeneLoc Exon Structure for
THYN1
ECgene alternative splicing isoforms for
THYN1

Expression for THYN1 Gene

mRNA expression in normal human tissues for THYN1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for THYN1 Gene

SOURCE GeneReport for Unigene cluster for THYN1 Gene Hs.13645

genes like me logo Genes that share expressions with THYN1: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for THYN1 Gene

Orthologs for THYN1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for THYN1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia THYN1 35
  • 99.7 (n)
  • 99.56 (a)
THYN1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia THYN1 36
  • 72 (a)
OneToOne
dog
(Canis familiaris)
Mammalia THYN1 35
  • 85.56 (n)
  • 78.8 (a)
THYN1 36
  • 76 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Thyn1 35
  • 84.15 (n)
  • 82.22 (a)
Thyn1 16
Thyn1 36
  • 82 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia THYN1 36
  • 69 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 66 (a)
OneToMany
-- 36
  • 61 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Thyn1 35
  • 84.89 (n)
  • 82.67 (a)
chicken
(Gallus gallus)
Aves THYN1 35
  • 68.18 (n)
  • 71.36 (a)
THYN1 36
  • 63 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia THYN1 36
  • 65 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.19690 35
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.9991 35
thyn1 35
  • 72.29 (n)
  • 74.7 (a)
zebrafish
(Danio rerio)
Actinopterygii thyn1 35
  • 68.93 (n)
  • 69.9 (a)
thyn1 36
  • 62 (a)
OneToOne
zgc66269 35
bread mold
(Neurospora crassa)
Ascomycetes NCU05893 35
  • 50.58 (n)
  • 45.93 (a)
Species with no ortholog for THYN1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for THYN1 Gene

ENSEMBL:
Gene Tree for THYN1 (if available)
TreeFam:
Gene Tree for THYN1 (if available)

Paralogs for THYN1 Gene

No data available for Paralogs for THYN1 Gene

Variants for THYN1 Gene

Sequence variations from dbSNP and Humsavar for THYN1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs2509063 -- 134,248,300(-) TTTCA(A/C/G)TAAAA utr-variant-3-prime
rs3741103 -- 134,251,244(-) GTGGA(A/T)GACTC synonymous-codon, reference, missense
rs3816440 -- 134,248,640(+) TACTG(G/T)GTAAT intron-variant
rs4489761 -- 134,250,250(+) TCTCA(C/G)GCGAC intron-variant
rs11223733 -- 134,248,694(+) acagg(C/T)gagga intron-variant

Structural Variations from Database of Genomic Variants (DGV) for THYN1 Gene

Variant ID Type Subtype PubMed ID
nsv521581 CNV Gain 19592680
nsv832299 CNV Loss 17160897
nsv898474 CNV Loss 21882294
nsv898475 CNV Gain 21882294

Relevant External Links for THYN1 Gene

HapMap Linkage Disequilibrium report
THYN1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for THYN1 Gene

Disorders for THYN1 Gene

No disorders were found for THYN1 Gene.

No data available for UniProtKB/Swiss-Prot for THYN1 Gene

Publications for THYN1 Gene

  1. Identification, expression, and purification of a unique stable domain from human HSPC144 protein. (PMID: 15939300) Song A.X. … Hu H.Y. (Protein Expr. Purif. 2005) 3 4 23
  2. Determining the DUF55-domain structure of human thymocyte nuclear protein 1 from crystals partially twinned by tetartohedry. (PMID: 19237743) Yu F. … He J. (Acta Crystallogr. D 2009) 3 4 23
  3. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang Q.-H. … Chen Z. (Genome Res. 2000) 3 4
  4. Molecular cloning and characterization of the mouse thymocyte protein gene. (PMID: 12384300) Miyaji H. … Mizuguchi J. (Gene 2002) 2 3
  5. Anti-IgM-induced down-regulation of nuclear Thy28 protein expression in Ramos B lymphoma cells. (PMID: 14601557) Jiang X.Z. … Mizuguchi J. (Apoptosis 2003) 2 3

Products for THYN1 Gene

Sources for THYN1 Gene

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