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Aliases for THYN1 Gene

Aliases for THYN1 Gene

  • Thymocyte Nuclear Protein 1 2 3 5
  • Thymocyte Protein Thy28 3 4
  • THY28 3 4
  • HSPC144 3
  • THY28KD 3
  • MDS012 3
  • MY105 3

External Ids for THYN1 Gene

Previous GeneCards Identifiers for THYN1 Gene

  • GC11M133624
  • GC11M134118
  • GC11M130072

Summaries for THYN1 Gene

Entrez Gene Summary for THYN1 Gene

  • This gene encodes a protein that is highly conserved among vertebrates and plant species and may be involved in the induction of apoptosis. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

GeneCards Summary for THYN1 Gene

THYN1 (Thymocyte Nuclear Protein 1) is a Protein Coding gene.

UniProtKB/Swiss-Prot for THYN1 Gene

  • Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC.

Gene Wiki entry for THYN1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for THYN1 Gene

Genomics for THYN1 Gene

Regulatory Elements for THYN1 Gene

Enhancers for THYN1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11F134252 1.1 ENCODE 18.9 +0.0 3 2.1 PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF207 ZNF143 SP3 ACAD8 THYN1 GLB1L3 PIR51401
GH11F134228 1 Ensembl ENCODE 11.6 +22.9 22901 4.2 CTCF PKNOX1 RAD21 RELA SCRT2 CREM MAZ MTA2 CBFB REST ACAD8 THYN1 GLB1L3 ENSG00000255348 LOC100533644 JAM3 NCAPD3 PIR33942
GH11F134232 0.2 ENCODE 11.6 +20.5 20469 0.4 THYN1 ACAD8 GLB1L3 ENSG00000255348 LOC100533644 NCAPD3 PIR33942
GH11F134050 1.5 FANTOM5 Ensembl ENCODE 11 +202.4 202372 1.3 ZNF48 ZNF2 RAD21 GLIS2 EGR1 ZNF143 ZNF391 EGR2 ZNF654 REST THYN1 SPATA19 JAM3 B3GAT1 LOC105369582
GH11F134046 0.9 Ensembl ENCODE 10.2 +205.8 205807 1.4 MAZ SP3 KLF17 ZIC2 ZFHX2 GLIS1 KLF9 FOS MAFK EGR2 JAM3 THYN1 LOC105369582
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around THYN1 on UCSC Golden Path with GeneCards custom track

Promoters for THYN1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000571846 -199 2801 CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF207 ZNF143 SP3 SP5

Genomic Location for THYN1 Gene

Chromosome:
11
Start:
134,248,278 bp from pter
End:
134,253,401 bp from pter
Size:
5,124 bases
Orientation:
Minus strand

Genomic View for THYN1 Gene

Genes around THYN1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
THYN1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for THYN1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for THYN1 Gene

Proteins for THYN1 Gene

  • Protein details for THYN1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P016-THYN1_HUMAN
    Recommended name:
    Thymocyte nuclear protein 1
    Protein Accession:
    Q9P016
    Secondary Accessions:
    • Q567Q2
    • Q9H3L4
    • Q9HC20

    Protein attributes for THYN1 Gene

    Size:
    225 amino acids
    Molecular mass:
    25697 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for THYN1 Gene

    Alternative splice isoforms for THYN1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for THYN1 Gene

Post-translational modifications for THYN1 Gene

No data available for DME Specific Peptides for THYN1 Gene

Domains & Families for THYN1 Gene

Protein Domains for THYN1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for THYN1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with THYN1: view

No data available for Gene Families and UniProtKB/Swiss-Prot for THYN1 Gene

Function for THYN1 Gene

Molecular function for THYN1 Gene

UniProtKB/Swiss-Prot Function:
Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC.
genes like me logo Genes that share phenotypes with THYN1: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for THYN1 Gene

Localization for THYN1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for THYN1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for THYN1 Gene COMPARTMENTS Subcellular localization image for THYN1 gene
Compartment Confidence
nucleus 5
cytosol 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for THYN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS 14601557
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with THYN1: view

Pathways & Interactions for THYN1 Gene

SuperPathways for THYN1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for THYN1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for THYN1 Gene

Transcripts for THYN1 Gene

Unigene Clusters for THYN1 Gene

Thymocyte nuclear protein 1:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for THYN1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9
SP1: - - - - - -
SP2: - - - - -
SP3: - - - - - -
SP4: - - -
SP5: - - - -
SP6: - -
SP7:
SP8:

Relevant External Links for THYN1 Gene

GeneLoc Exon Structure for
THYN1
ECgene alternative splicing isoforms for
THYN1

Expression for THYN1 Gene

mRNA expression in normal human tissues for THYN1 Gene

Protein differential expression in normal tissues from HIPED for THYN1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (18.4) and Uterus (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for THYN1 Gene



Protein tissue co-expression partners for THYN1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of THYN1 Gene:

THYN1

SOURCE GeneReport for Unigene cluster for THYN1 Gene:

Hs.13645
genes like me logo Genes that share expression patterns with THYN1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for THYN1 Gene

Orthologs for THYN1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for THYN1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia THYN1 34 35
  • 99.7 (n)
dog
(Canis familiaris)
Mammalia THYN1 34 35
  • 85.56 (n)
rat
(Rattus norvegicus)
Mammalia Thyn1 34
  • 84.89 (n)
mouse
(Mus musculus)
Mammalia Thyn1 34 16 35
  • 84.15 (n)
cow
(Bos Taurus)
Mammalia THYN1 35
  • 72 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia THYN1 35
  • 69 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 66 (a)
OneToMany
-- 35
  • 61 (a)
OneToMany
chicken
(Gallus gallus)
Aves THYN1 34 35
  • 68.18 (n)
lizard
(Anolis carolinensis)
Reptilia THYN1 35
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia thyn1 34
  • 72.29 (n)
Str.9991 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.19690 34
zebrafish
(Danio rerio)
Actinopterygii thyn1 34 35
  • 68.93 (n)
zgc66269 34
bread mold
(Neurospora crassa)
Ascomycetes NCU05893 34
  • 50.58 (n)
Species where no ortholog for THYN1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for THYN1 Gene

ENSEMBL:
Gene Tree for THYN1 (if available)
TreeFam:
Gene Tree for THYN1 (if available)

Paralogs for THYN1 Gene

No data available for Paralogs for THYN1 Gene

Variants for THYN1 Gene

Sequence variations from dbSNP and Humsavar for THYN1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs35181923 Benign 134,253,620(+) CTGCC(C/G)GCGTT upstream-variant-2KB, reference, missense, utr-variant-5-prime
rs1048761 -- 134,254,230(-) CTTGT(G/T)CAGTT intron-variant, upstream-variant-2KB
rs111412607 -- 134,251,768(+) CTCAC(G/T)GTGGC intron-variant, upstream-variant-2KB
rs111453185 -- 134,249,790(+) CCCTG(G/T)AGGAA intron-variant
rs111568257 -- 134,249,753(+) TTAAG(A/G)TATAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for THYN1 Gene

Variant ID Type Subtype PubMed ID
esv3892114 CNV gain 25118596
nsv521581 CNV gain 19592680
nsv556598 CNV loss 21841781
nsv832299 CNV loss 17160897

Variation tolerance for THYN1 Gene

Residual Variation Intolerance Score: 37.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.73; 15.51% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for THYN1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
THYN1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for THYN1 Gene

Disorders for THYN1 Gene

Relevant External Links for THYN1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
THYN1

No disorders were found for THYN1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for THYN1 Gene

Publications for THYN1 Gene

  1. Determining the DUF55-domain structure of human thymocyte nuclear protein 1 from crystals partially twinned by tetartohedry. (PMID: 19237743) Yu F. … He J. (Acta Crystallogr. D 2009) 3 4 22 64
  2. Identification, expression, and purification of a unique stable domain from human HSPC144 protein. (PMID: 15939300) Song A.X. … Hu H.Y. (Protein Expr. Purif. 2005) 3 4 22 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Anti-IgM-induced down-regulation of nuclear Thy28 protein expression in Ramos B lymphoma cells. (PMID: 14601557) Jiang X.Z. … Mizuguchi J. (Apoptosis 2003) 2 3 64
  5. Molecular cloning and characterization of the mouse thymocyte protein gene. (PMID: 12384300) Miyaji H. … Mizuguchi J. (Gene 2002) 2 3 64

Products for THYN1 Gene

Sources for THYN1 Gene

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