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Aliases for THYN1 Gene

Aliases for THYN1 Gene

  • Thymocyte Nuclear Protein 1 2 3 5
  • Thymocyte Protein Thy28 3 4
  • THY28 3 4
  • HSPC144 3
  • THY28KD 3
  • MDS012 3
  • MY105 3

External Ids for THYN1 Gene

Previous GeneCards Identifiers for THYN1 Gene

  • GC11M133624
  • GC11M134118
  • GC11M130072

Summaries for THYN1 Gene

Entrez Gene Summary for THYN1 Gene

  • This gene encodes a protein that is highly conserved among vertebrates and plant species and may be involved in the induction of apoptosis. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

GeneCards Summary for THYN1 Gene

THYN1 (Thymocyte Nuclear Protein 1) is a Protein Coding gene.

UniProtKB/Swiss-Prot for THYN1 Gene

  • Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC.

Gene Wiki entry for THYN1 Gene

Additional gene information for THYN1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for THYN1 Gene

Genomics for THYN1 Gene

Regulatory Elements for THYN1 Gene

Enhancers for THYN1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11H134252 1.1 ENCODE 18.9 +0.0 3 2 PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF766 ZNF207 ZNF143 ACAD8 THYN1 GLB1L3 PIR51401
GH11H134050 1.6 FANTOM5 Ensembl ENCODE dbSUPER 11 +202.4 202372 1 CTCF MXI1 BACH1 ZIC2 ZNF2 BCL11B RAD21 ZFHX2 GLIS2 EGR1 THYN1 SPATA19 JAM3 B3GAT1 LOC105369582
GH11H134715 0.7 dbSUPER 21.9 -464.6 -464634 4 ZNF146 ZFP64 ZC3H11A ZNF140 REST ZNF623 ZNF781 ZNF518A ZNF697 ZNF555 THYN1 NCAPD3 LOC105369584 LOC729305
GH11H134868 0.9 ENCODE 13.7 -615.4 -615391 0 HDAC1 ZNF473 ZSCAN4 ZNF133 SIN3A RAD21 ZEB1 GATA2 ZNF366 ZNF143 LOC100128239 THYN1 GC11P134876 GC11P134832
GH11H134118 1.4 FANTOM5 Ensembl ENCODE dbSUPER 8.2 +132.8 132810 4 GATA3 POLR2A IKZF1 JUN FOS NFE2 NCAPD3 JAM3 LOC100533644 ENSG00000255348 IGSF9B GLB1L3 THYN1 GC11M134124 LOC102725195
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around THYN1 on UCSC Golden Path with GeneCards custom track

Promoters for THYN1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000047446 -99 2201 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF766 ZNF207 ZNF143 SP3

Genomic Location for THYN1 Gene

Chromosome:
11
Start:
134,248,278 bp from pter
End:
134,253,401 bp from pter
Size:
5,124 bases
Orientation:
Minus strand

Genomic View for THYN1 Gene

Genes around THYN1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
THYN1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for THYN1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for THYN1 Gene

Proteins for THYN1 Gene

  • Protein details for THYN1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P016-THYN1_HUMAN
    Recommended name:
    Thymocyte nuclear protein 1
    Protein Accession:
    Q9P016
    Secondary Accessions:
    • Q567Q2
    • Q9H3L4
    • Q9HC20

    Protein attributes for THYN1 Gene

    Size:
    225 amino acids
    Molecular mass:
    25697 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for THYN1 Gene

    Alternative splice isoforms for THYN1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for THYN1 Gene

Post-translational modifications for THYN1 Gene

No data available for DME Specific Peptides for THYN1 Gene

Domains & Families for THYN1 Gene

Gene Families for THYN1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for THYN1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for THYN1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with THYN1: view

No data available for UniProtKB/Swiss-Prot for THYN1 Gene

Function for THYN1 Gene

Molecular function for THYN1 Gene

UniProtKB/Swiss-Prot Function:
Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC.
genes like me logo Genes that share phenotypes with THYN1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for THYN1
  • Applied Biological Materials Clones for THYN1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for THYN1 Gene

Localization for THYN1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for THYN1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for THYN1 gene
Compartment Confidence
nucleus 5
cytosol 2
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli fibrillar center (3)
  • Nucleus (3)
  • Cytosol (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for THYN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS 14601557
genes like me logo Genes that share ontologies with THYN1: view

Pathways & Interactions for THYN1 Gene

SuperPathways for THYN1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for THYN1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for THYN1 Gene

Drugs & Compounds for THYN1 Gene

No Compound Related Data Available

Transcripts for THYN1 Gene

Unigene Clusters for THYN1 Gene

Thymocyte nuclear protein 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for THYN1
  • Applied Biological Materials Clones for THYN1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for THYN1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9
SP1: - - - - - -
SP2: - - - - -
SP3: - - - - - -
SP4: - - -
SP5: - - - -
SP6: - -
SP7:
SP8:

Relevant External Links for THYN1 Gene

GeneLoc Exon Structure for
THYN1
ECgene alternative splicing isoforms for
THYN1

Expression for THYN1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for THYN1 Gene

Protein differential expression in normal tissues from HIPED for THYN1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (18.4) and Uterus (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for THYN1 Gene



Protein tissue co-expression partners for THYN1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of THYN1 Gene:

THYN1

SOURCE GeneReport for Unigene cluster for THYN1 Gene:

Hs.13645

Evidence on tissue expression from TISSUES for THYN1 Gene

  • Nervous system(4.6)
  • Liver(4.3)
  • Blood(4.2)
genes like me logo Genes that share expression patterns with THYN1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for THYN1 Gene

Orthologs for THYN1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for THYN1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia THYN1 33 34
  • 99.7 (n)
dog
(Canis familiaris)
Mammalia THYN1 33 34
  • 85.56 (n)
rat
(Rattus norvegicus)
Mammalia Thyn1 33
  • 84.89 (n)
mouse
(Mus musculus)
Mammalia Thyn1 33 16 34
  • 84.15 (n)
cow
(Bos Taurus)
Mammalia THYN1 34
  • 72 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia THYN1 34
  • 69 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 66 (a)
OneToMany
-- 34
  • 61 (a)
OneToMany
chicken
(Gallus gallus)
Aves THYN1 33 34
  • 68.18 (n)
lizard
(Anolis carolinensis)
Reptilia THYN1 34
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia thyn1 33
  • 72.29 (n)
Str.9991 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.19690 33
zebrafish
(Danio rerio)
Actinopterygii thyn1 33 34
  • 68.93 (n)
zgc66269 33
bread mold
(Neurospora crassa)
Ascomycetes NCU05893 33
  • 50.58 (n)
Species where no ortholog for THYN1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for THYN1 Gene

ENSEMBL:
Gene Tree for THYN1 (if available)
TreeFam:
Gene Tree for THYN1 (if available)

Paralogs for THYN1 Gene

No data available for Paralogs for THYN1 Gene

Variants for THYN1 Gene

Sequence variations from dbSNP and Humsavar for THYN1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs112372624 Likely benign 134,253,534(+) GTCCC(A/G/T)CCAGT upstream-variant-2KB, utr-variant-5-prime
rs35181923 Likely benign 134,253,620(+) CTGCC(C/G)GCGTT upstream-variant-2KB, reference, missense, utr-variant-5-prime
rs886048021 Uncertain significance 134,253,699(+) ACCTC(C/T)TGCAT upstream-variant-2KB, reference, synonymous-codon, utr-variant-5-prime
rs1000054002 -- 134,254,346(+) TTATT(A/G)CCAGT intron-variant, upstream-variant-2KB
rs1000160445 -- 134,248,688(+) GTGTT(-/A)ACAGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for THYN1 Gene

Variant ID Type Subtype PubMed ID
esv3892114 CNV gain 25118596
nsv521581 CNV gain 19592680
nsv556598 CNV loss 21841781
nsv832299 CNV loss 17160897

Variation tolerance for THYN1 Gene

Residual Variation Intolerance Score: 37.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.73; 15.51% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for THYN1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
THYN1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for THYN1 Gene

Disorders for THYN1 Gene

Relevant External Links for THYN1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
THYN1

No disorders were found for THYN1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for THYN1 Gene

Publications for THYN1 Gene

  1. Determining the DUF55-domain structure of human thymocyte nuclear protein 1 from crystals partially twinned by tetartohedry. (PMID: 19237743) Yu F … He J (Acta crystallographica. Section D, Biological crystallography 2009) 3 4 22 60
  2. Identification, expression, and purification of a unique stable domain from human HSPC144 protein. (PMID: 15939300) Song AX … Hu HY (Protein expression and purification 2005) 3 4 22 60
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  4. Anti-IgM-induced down-regulation of nuclear Thy28 protein expression in Ramos B lymphoma cells. (PMID: 14601557) Jiang XZ … Mizuguchi J (Apoptosis : an international journal on programmed cell death 2003) 2 3 60
  5. Molecular cloning and characterization of the mouse thymocyte protein gene. (PMID: 12384300) Miyaji H … Mizuguchi J (Gene 2002) 2 3 60

Products for THYN1 Gene

  • Addgene plasmids for THYN1

Sources for THYN1 Gene

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