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Aliases for THY1 Gene

Aliases for THY1 Gene

  • Thy-1 Cell Surface Antigen 2 3
  • Thy-1 Antigen 3 4
  • CDw90 3 4
  • Thy-1 Membrane Glycoprotein 3
  • Thy-1 T-Cell Antigen 3
  • CD90 Antigen 4
  • CD90 3

External Ids for THY1 Gene

Previous GeneCards Identifiers for THY1 Gene

  • GC11M121288
  • GC11M120800
  • GC11M119322
  • GC11M118826
  • GC11M118795
  • GC11M119288
  • GC11M115230

Summaries for THY1 Gene

GeneCards Summary for THY1 Gene

THY1 (Thy-1 Cell Surface Antigen) is a Protein Coding gene. Diseases associated with THY1 include central retinal artery occlusion and mesangial proliferative glomerulonephritis. Among its related pathways are Integrin Pathway and amb2 Integrin signaling. GO annotations related to this gene include protein kinase binding.

UniProtKB/Swiss-Prot for THY1 Gene

  • May play a role in cell-cell or cell-ligand interactions during synaptogenesis and other events in the brain

Gene Wiki entry for THY1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for THY1 Gene

Genomics for THY1 Gene

Regulatory Elements for THY1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for THY1 Gene

Start:
119,417,378 bp from pter
End:
119,424,985 bp from pter
Size:
7,608 bases
Orientation:
Minus strand

Genomic View for THY1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for THY1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for THY1 Gene

Proteins for THY1 Gene

  • Protein details for THY1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P04216-THY1_HUMAN
    Recommended name:
    Thy-1 membrane glycoprotein
    Protein Accession:
    P04216
    Secondary Accessions:
    • Q16008
    • Q9NSP1

    Protein attributes for THY1 Gene

    Size:
    161 amino acids
    Molecular mass:
    17935 Da
    Quaternary structure:
    No Data Available

neXtProt entry for THY1 Gene

Proteomics data for THY1 Gene at MOPED

Post-translational modifications for THY1 Gene

  • Glycosylation at Asn42, Asn79, Asn119, and Asn139
  • Modification sites at PhosphoSitePlus

Other Protein References for THY1 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for THY1 (THY1)

No data available for DME Specific Peptides for THY1 Gene

Domains for THY1 Gene

Gene Families for THY1 Gene

HGNC:
  • CD :CD molecules
  • IGD :Immunoglobulin superfamily / Immunoglobulin-like domain containing

Protein Domains for THY1 Gene

Graphical View of Domain Structure for InterPro Entry

P04216

UniProtKB/Swiss-Prot:

THY1_HUMAN :
  • P04216
Domain:
  • Contains 1 Ig-like V-type (immunoglobulin-like) domain.
genes like me logo Genes that share domains with THY1: view

Function for THY1 Gene

Molecular function for THY1 Gene

GENATLAS Biochemistry: Thy-1 cell surface antigen
UniProtKB/Swiss-Prot Function: May play a role in cell-cell or cell-ligand interactions during synaptogenesis and other events in the brain

Gene Ontology (GO) - Molecular Function for THY1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity ISS --
GO:0005178 integrin binding IPI 15004192
GO:0005515 protein binding IPI 7513706
GO:0019899 enzyme binding --
GO:0019901 protein kinase binding IEA --
genes like me logo Genes that share ontologies with THY1: view
genes like me logo Genes that share phenotypes with THY1: view

Animal Models for THY1 Gene

MGI Knock Outs for THY1:

Animal Model Products

CRISPR Products

miRNA for THY1 Gene

miRTarBase miRNAs that target THY1

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for THY1 Gene

Localization for THY1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for THY1 Gene

Cell membrane; Lipid-anchor, GPI-anchor.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for THY1 Gene COMPARTMENTS Subcellular localization image for THY1 gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 4
cytoskeleton 3
extracellular 3
cytosol 2
nucleus 2

Gene Ontology (GO) - Cellular Components for THY1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IDA --
GO:0005829 cytosol IEA --
GO:0005886 plasma membrane ISS --
GO:0005887 integral component of plasma membrane TAS 2864289
GO:0005925 focal adhesion IDA 21423176
genes like me logo Genes that share ontologies with THY1: view

Pathways for THY1 Gene

genes like me logo Genes that share pathways with THY1: view

Pathways by source for THY1 Gene

1 Qiagen pathway for THY1 Gene
3 Cell Signaling Technology pathways for THY1 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for THY1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis ISS --
GO:0006469 negative regulation of protein kinase activity ISS --
GO:0007010 cytoskeleton organization ISS --
GO:0016337 single organismal cell-cell adhesion ISS --
GO:0030336 negative regulation of cell migration ISS --
genes like me logo Genes that share ontologies with THY1: view

Compounds for THY1 Gene

(2) Novoseek inferred chemical compound relationships for THY1 Gene

Compound -log(P) Hits PubMed IDs
lipid 0 4
tyrosine 0 1
genes like me logo Genes that share compounds with THY1: view

Transcripts for THY1 Gene

mRNA/cDNA for THY1 Gene

Unigene Clusters for THY1 Gene

Thy-1 cell surface antigen:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for THY1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for THY1 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c · 6d ^ 7 ^ 8a · 8b · 8c · 8d ^ 9a · 9b · 9c
SP1: - - - -
SP2: - - -
SP3: - - - - - - -
SP4: - - - -
SP5: - - - - - -
SP6: - - -
SP7: - - - - - - - -
SP8: - - - - -
SP9: - - - -
SP10: - - -
SP11: - - - - -
SP12: - -

Relevant External Links for THY1 Gene

GeneLoc Exon Structure for
THY1
ECgene alternative splicing isoforms for
THY1

Expression for THY1 Gene

mRNA expression in normal human tissues for THY1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for THY1 Gene

This gene is overexpressed in Brain - Cortex (5.3), Brain - Frontal Cortex (BA9) (4.8), and Brain - Anterior cingulate cortex (BA24) (4.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for THY1 Gene

SOURCE GeneReport for Unigene cluster for THY1 Gene Hs.644697

genes like me logo Genes that share expressions with THY1: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for THY1 Gene

Orthologs for THY1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for THY1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia THY1 35
  • 99.59 (n)
  • 100 (a)
THY1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia THY1 35
  • 80.12 (n)
  • 73.91 (a)
THY1 36
  • 74 (a)
OneToOne
dog
(Canis familiaris)
Mammalia THY1 35
  • 85.71 (n)
  • 82.61 (a)
THY1 36
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Thy1 35
  • 76.81 (n)
  • 70.19 (a)
Thy1 16
Thy1 36
  • 69 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia THY1 36
  • 60 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia THY1 36
  • 50 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Thy1 35
  • 77.85 (n)
  • 70.81 (a)
chicken
(Gallus gallus)
Aves gga-mir-1466 36
  • 49 (a)
OneToOne
THY1 35
  • 65.83 (n)
  • 54.37 (a)
lizard
(Anolis carolinensis)
Reptilia THY1 36
  • 48 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia thy1 35
  • 45.76 (n)
  • 36.02 (a)
Species with no ortholog for THY1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for THY1 Gene

ENSEMBL:
Gene Tree for THY1 (if available)
TreeFam:
Gene Tree for THY1 (if available)

Paralogs for THY1 Gene

No data available for Paralogs for THY1 Gene

Variants for THY1 Gene

Structural Variations from Database of Genomic Variants (DGV) for THY1 Gene

Variant ID Type Subtype PubMed ID
nsv898418 CNV Loss 21882294
nsv832284 CNV Gain 17160897

Relevant External Links for THY1 Gene

HapMap Linkage Disequilibrium report
THY1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for THY1 Gene

Disorders for THY1 Gene

(10) Novoseek inferred disease relationships for THY1 Gene

Disease -log(P) Hits PubMed IDs
proliferative nephritis 70.9 2
lymphoblastic leukemia acute 26.9 1
thymoma 23.2 1
acute leukemia 21 2
cancer 5.41 1

Relevant External Links for THY1

Genetic Association Database (GAD)
THY1
Human Genome Epidemiology (HuGE) Navigator
THY1
Tumor Gene Database (TGDB):
THY1
genes like me logo Genes that share disorders with THY1: view

No data available for UniProtKB/Swiss-Prot for THY1 Gene

Publications for THY1 Gene

  1. The human Thy-1 gene: structure and chromosomal location. (PMID: 2864690) Seki T. … Silver J. (Proc. Natl. Acad. Sci. U.S.A. 1985) 2 3 4
  2. Evidence for enhanced Thy-1 (CD90) expression in orbital fibroblasts of patients with Graves' ophthalmopathy. (PMID: 18976167) Khoo T.K. … Bahn R.S. (Thyroid 2008) 3 23
  3. [The study of CD90 expressing in orbital fibroblasts of thyroid associated ophthalmopathy]. (PMID: 17243294) Tang L. … Tang J. (Sichuan Da Xue Xue Bao Yi Xue Ban 2006) 3 23
  4. THY1 expression is associated with tumor suppression of human ovarian cancer. (PMID: 12781446) Abeysinghe H.R. … Wang N. (Cancer Genet. Cytogenet. 2003) 3 23
  5. Human Thy-1 (CD90) on activated endothelial cells is a counterreceptor for the leukocyte integrin Mac-1 (CD11b/CD18). (PMID: 15004192) Wetzel A. … Saalbach A. (J. Immunol. 2004) 3 23

Products for THY1 Gene

  • Addgene plasmids for THY1

Sources for THY1 Gene

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