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THY1 Gene

protein-coding   GIFtS: 64
GCID: GC11M119288

Thy-1 Cell Surface Antigen

  See THY1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Thy-1 Cell Surface Antigen1 2     Thy-1 Membrane Glycoprotein2
Thy-1 Antigen2 3     Thy-1 T-Cell Antigen2
CDw902 3     CD90 Antigen3
CD902     

External Ids:    HGNC: 118011   Entrez Gene: 70702   Ensembl: ENSG000001540967   OMIM: 1882305   UniProtKB: P042163   

Export aliases for THY1 gene to outside databases

Previous GC identifers: GC11M121288 GC11M120800 GC11M119322 GC11M118826 GC11M118795 GC11M115230


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for THY1 Gene:
THY1 (Thy-1 cell surface antigen) is a protein-coding gene. Diseases associated with THY1 include central retinal artery occlusion, and mesangial proliferative glomerulonephritis. GO annotations related to this gene include Rho GTPase activator activity and protein kinase binding.

UniProtKB/Swiss-Prot: THY1_HUMAN, P04216
Function: May play a role in cell-cell or cell-ligand interactions during synaptogenesis and other events in the
brain

Gene Wiki entry for THY1 (CD90) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NC_018922.2  NT_033899.9  
Regulatory elements:
   Regulatory transcription factor binding sites in the THY1 gene promoter:
         c-Fos   p53   AP-1   GR-beta   ATF-2   STAT3   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 5): THY1 promoter sequence
   Search Chromatin IP Primers for THY1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat THY1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q23.3   Ensembl cytogenetic band:  11q23.3   HGNC cytogenetic band: 11q23.3

THY1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
THY1 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M119288:  view genomic region     (about GC identifiers)

Start:
119,288,090 bp from pter      End:
119,295,695 bp from pter
Size:
7,606 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: THY1_HUMAN, P04216 (See protein sequence)
Recommended Name: Thy-1 membrane glycoprotein precursor  
Size: 161 amino acids; 17935 Da
Secondary accessions: Q16008 Q9NSP1

Explore the universe of human proteins at neXtProt for THY1: NX_P04216

Explore proteomics data for THY1 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn42, Asn79, Asn119, Asn139
  • Modification sites at PhosphoSitePlus

  • See THY1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_006279.2  
    ENSEMBL proteins: 
     ENSP00000284240   ENSP00000431301   ENSP00000432051   ENSP00000432808   ENSP00000464248  
     ENSP00000435753  

    THY1 Human Recombinant Protein Products:

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    Novus Biologicals THY1 Proteins
    Novus Biologicals THY1 Lysates
    Sino Biological Recombinant Protein for THY1
    Sino Biological Cell Lysate for THY1
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for THY1 

    THY1 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of THY1
    R&D Systems Antibodies for THY1 (CD90/Thy1)
    Cell Signaling Technology (CST) Antibodies for THY1 
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    OriGene Custom Antibody Services for THY1
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    Abcam antibodies for THY1
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibody for THY1
    LSBio Antibodies in human, mouse, rat for THY1

    THY1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    R&D Systems Proteome Profiler Antibody Arrays for THY1 (CD90/Thy1)
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    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for THY1 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CD: CD molecules
    IGD: Immunoglobulin superfamily / Immunoglobulin-like domain containing

    4 InterPro protein domains:
     IPR007110 Ig-like_dom
     IPR003599 Ig_sub
     IPR013783 Ig-like_fold
     IPR013151 Immunoglobulin

    Graphical View of Domain Structure for InterPro Entry P04216

    ProtoNet protein and cluster: P04216

    1 Blocks protein domain: IPB003599 Immunoglobulin subtype

    UniProtKB/Swiss-Prot: THY1_HUMAN, P04216
    Similarity: Contains 1 Ig-like V-type (immunoglobulin-like) domain


    Find genes that share domains with THY1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: THY1_HUMAN, P04216
    Function: May play a role in cell-cell or cell-ligand interactions during synaptogenesis and other events in the
    brain

         Genatlas biochemistry entry for THY1:
    Thy-1 cell surface antigen

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005100Rho GTPase activator activity ISS--
    GO:0005178integrin binding IPI15004192
    GO:0005515protein binding IPI7513706
    GO:0019899enzyme binding ----
    GO:0019901protein kinase binding IEA--
         
    Find genes that share ontologies with THY1           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for THY1:
     Decreased number of cells in m  Increased gamma-H2AX phosphory  Synthetic lethal with c-Myc af 

         3 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Thy1):
     nervous system  normal  respiratory system 

    Find genes that share phenotypes with THY1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for THY1: Thy1tm1Kak Thy1tm1Rjmo

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for THY1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for THY1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for THY1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for THY1

    miRNA
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    miRTarBase miRNAs that target THY1:
    hsa-mir-1 (MIRT024103)

    Block miRNA regulation of human, mouse, rat THY1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate THY1 (see all 16):
    hsa-miR-4291 hsa-miR-125a-5p hsa-miR-4300 hsa-miR-875-3p hsa-miR-922 hsa-miR-4328 hsa-miR-520a-5p hsa-miR-103a
    SwitchGear 3'UTR luciferase reporter plasmidTHY1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for THY1
    Predesigned siRNA for gene silencing in human, mouse, rat THY1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for THY1

    Clone
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    OriGene ORF clones in mouse, rat for THY1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: THY1 (NM_006288)
    Sino Biological Human cDNA Clone for THY1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for THY1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat THY1
    Addgene plasmids for THY1 

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for THY1

    Flow Cytometry
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    eBioscience FlowRNA Probe Sets ( VA1-12482) for THY1 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    THY1_HUMAN, P04216: Cell membrane; Lipid-anchor, GPI-anchor (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    endoplasmic reticulum4
    cytoskeleton3
    extracellular3
    cytosol2
    nucleus2

    Gene Ontology (GO): Selected cellular component terms (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005783endoplasmic reticulum IDA--
    GO:0005829cytosol IEA--
    GO:0005886plasma membrane ISS--
    GO:0005887integral component of plasma membrane TAS2864289
    GO:0009897external side of plasma membrane ISS--

    Find genes that share ontologies with THY1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for THY1 About   (see all 9)  
    See pathways by source

    SuperPathContained pathways About
    1Integrin Pathway
    Transendothelial Migration of Leukocytes0.38
    2Selected targets of Oct 3 4
    Selected targets of Oct 3 4
    3Neuroscience
    Neuroscience
    4Lymphocyte Signaling
    Lymphocyte Signaling
    5Leukocyte transendothelial migration
    Leukocyte transendothelial migration


    Find genes that share SuperPaths with THY1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for THY1
        Transendothelial Migration of Leukocytes

    3 Cell Signaling Technology (CST) Pathways for THY1
        Neuroscience
    Lymphocyte Signaling
    Adhesion

    3 BioSystems Pathways for THY1
        Cardiac Progenitor Differentiation
    IL4-mediated signaling events
    amb2 Integrin signaling



    1 Kegg Pathway  (Kegg details for THY1):
        Leukocyte transendothelial migration

        Pathway & Disease-focused RT2 Profiler PCR Arrays including THY1: 
              Mesenchymal Stem Cell in human mouse rat
              T-cell & B-cell Activation in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for THY1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 13)

    Selected Interacting proteins for THY1 (P042162, 3 ENSP000002842404) via UniProtKB, MINT, STRING, and/or I2D (see all 18)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FYNP062413, ENSP000003576564I2D: score=3 STRING: ENSP00000357656
    LCKP062393, ENSP000003378254I2D: score=3 STRING: ENSP00000337825
    ITGAVP067563, ENSP000002610234I2D: score=2 STRING: ENSP00000261023
    ITGAMP112153, ENSP000002874974I2D: score=1 STRING: ENSP00000287497
    SYPP082473, ENSP000002632334I2D: score=1 STRING: ENSP00000263233
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001525angiogenesis ISS--
    GO:0006469negative regulation of protein kinase activity ISS--
    GO:0007010cytoskeleton organization ISS--
    GO:0016337cell-cell adhesion ISS--
    GO:0030336negative regulation of cell migration ISS--

    Find genes that share ontologies with THY1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for THY1

    2 Novoseek inferred chemical compound relationships for THY1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lipid 0 5 17027000 (3), 15093746 (1)
    tyrosine 0 2 15093746 (1)



    Find genes that share compounds with THY1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for THY1 gene: 
    NM_006288.3  

    Unigene Cluster for THY1:

    Thy-1 cell surface antigen
    Hs.644697  [show with all ESTs]
    Unigene Representative Sequence: AK090996
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000284240(uc001pwr.3) ENST00000584021 ENST00000528522 ENST00000528295
    ENST00000527590 ENST00000524970 ENST00000580275 ENST00000524659 ENST00000532974
    ENST00000533840
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate THY1 (see all 16):
    hsa-miR-4291 hsa-miR-125a-5p hsa-miR-4300 hsa-miR-875-3p hsa-miR-922 hsa-miR-4328 hsa-miR-520a-5p hsa-miR-103a
    SwitchGear 3'UTR luciferase reporter plasmidTHY1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat THY1
    Clone
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    Addgene plasmids for THY1 
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat THY1
      QuantiTect SYBR Green Assays in human, mouse, rat THY1
      QuantiFast Probe-based Assays in human, mouse, rat THY1
    Flow Cytometry
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    eBioscience FlowRNA Probe Sets ( VA1-12482) for THY1 

    Additional mRNA sequence: 

    AF261093.1 AK057865.1 AK090644.1 AK090996.1 AK094374.1 AK314018.1 AL161958.1 BC005175.2 
    BC037832.1 BC065559.1 S59749.1 

    Selected DOTS entries (see all 35):

    DT.100879495  DT.449730  DT.100879521  DT.100879522  DT.100879501  DT.100879500  DT.91734104  DT.95374065 
    DT.100879515  DT.100879514  DT.100879505  DT.97786623  DT.120730329  DT.102835886  DT.95374052  DT.92452338 
    DT.120730315  DT.100648633  DT.95374053  DT.100879494  DT.95374068  DT.97776373  DT.100723539  DT.100811997 

    Selected AceView cDNA sequences (see all 719):

    CF528522 AI086967 AI288047 CR621600 CR620763 CA424068 AA902143 AL546583 
    CR613179 AW614885 CR612556 BQ632130 CR601651 AI754264 CA946700 AA376089 
    AU117958 BF446993 AI365342 AI679827 AI858867 BG910865 BE382899 CB153194 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for THY1 (see all 12)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c · 6d ^ 7 ^ 8a · 8b · 8c · 8d ^ 9a · 9b · 9c
    SP1:                          -     -           -     -                                                                     
    SP2:                          -                 -     -                                                                     
    SP3:        -     -     -     -     -           -     -                                                                     
    SP4:                          -     -           -     -                                                                     
    SP5:                          -     -           -     -     -     -                                                         


    ECgene alternative splicing isoforms for THY1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    THY1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAGTGAGACC
    THY1 Expression
    About this image


    THY1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 35) fully expand
     
     Mesenchymal Stem Cells
             Bone Marrow Stromal Cells Bone Marrow
             Decidua-derived mesenchymal stem cells
             Mesenchymal-like stem cells
     
     Bone (Muscoskeletal System)    fully expand to see all 34 entries
             Bone Marrow Stromal Cells Bone Marrow
             Bone marrow-derived mesenchymal stem cell (mouse)
     
     Umbilical Cord (Extraembryonic Tissues)    fully expand to see all 14 entries
             Mesenchymal Stem Cells Wharton's Jelly
             Umbilical tissue-derived cells (CNTO2476)
             Human Umbilical Vein Smooth Muscle Cells (HUVSMC)   
     
     Adipose (Muscoskeletal System)    fully expand to see all 12 entries
             Mesenchymal Stem Cells Subcutaneous White Adipose
             Adipose-derived stromal cells
     
     Fibroblasts
             Cardiac Fibroblasts Myocardium
             Collagen-producing cells derived from skin fibroblasts
             SR1 Dermal Fibroblasts   
    THY1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    THY1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.644697
        Pathway & Disease-focused RT2 Profiler PCR Arrays including THY1: 
              Mesenchymal Stem Cell in human mouse rat
              T-cell & B-cell Activation in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for THY1
    OriGene qSTAR qPCR primer pairs in human, mouse for THY1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat THY1
    QuantiTect SYBR Green Assays in human, mouse, rat THY1
    QuantiFast Probe-based Assays in human, mouse, rat THY1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for THY1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for THY1 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Thy11 , 5 thymus cell antigen 1, theta1, 5 76.81(n)1
    70.19(a)1
      9 (24.52 cM)5
    218381  NM_009382.31  NP_033408.11 
     440433845 
    chicken
    (Gallus gallus)
    Aves THY11 Thy-1 cell surface antigen 65.83(n)
    54.37(a)
      378897  NM_204381.1  NP_989712.1 
    lizard
    (Anolis carolinensis)
    Reptilia THY16
    Thy-1 cell surface antigen
    48(a)
    1 ↔ 1
    GL344636.1(17911-25271)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia thy11 Thy-1 cell surface antigen 45.76(n)
    36.02(a)
      100101744  XM_004916045.1  XP_004916102.1 


    ENSEMBL Gene Tree for THY1 (if available)
    TreeFam Gene Tree for THY1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for THY1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv898418CNV Loss21882294
    nsv832284CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 188230    OMIM disorders: --

    3 diseases for THY1:    
    About MalaCards
    central retinal artery occlusion    mesangial proliferative glomerulonephritis    retinal artery occlusion

    8 diseases from the University of Copenhagen DISEASES database for THY1:
    Nephritis     Lymphoma     Proteinuria     Leukemia
    Thymoma     Hypersensitivity reaction type II disease     Fibrosarcoma     Sarcoma

    Find genes that share disorders with THY1           About GenesLikeMe

    10 Novoseek inferred disease relationships for THY1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    proliferative nephritis 70.9 2 1724021 (1), 8651905 (1)
    lymphoblastic leukemia acute 26.9 1 9695410 (1)
    thymoma 23.2 1 7818491 (1)
    acute leukemia 21 4 9401277 (1), 8547671 (1)
    cancer 5.41 2 10791904 (1)
    inflammation 0 1 17621180 (1)
    lymphoma non-hodgkins 0 2 10791904 (1)
    tumors 0 8 12392158 (4), 12781446 (2), 16255990 (1)
    melanoma 0 8 15897908 (5), 10571119 (1)
    solid tumor 0 1 2330681 (1)

    Genetic Association Database (GAD): THY1
    Human Genome Epidemiology (HuGE) Navigator: THY1 (2 documents)
    Tumor Gene Database (TGDB): THY1

    Export disorders for THY1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for THY1 gene, integrated from 10 sources (see all 174):
    (articles sorted by number of sources associating them with THY1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human Thy-1 gene: structure and chromosomal location. (PubMed id 2864690)1, 2, 3 Seki T.... Silver J. (Proc. Natl. Acad. Sci. U.S.A. 1985)
    2. Evaluation of 6 candidate genes on chromosome 11q23 for coeliac disease susceptibility: a case control study. (PubMed id 20478055)1, 4 Brophy K....McManus R. (BMC Med. Genet. 2010)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. cDNA cloning by amplification of circularized first strand cDNAs reveals non-IRE-regulated iron-responsive mRNAs. (PubMed id 10944468)1, 2 Ye Z. and Connor J.R. (Biochem. Biophys. Res. Commun. 2000)
    5. Expression of Thy-1 on human hematopoietic progenitor cells. (PubMed id 7683034)1, 2 Craig W.... Lansdorp P.M. (J. Exp. Med. 1993)
    6. Evidence for enhanced Thy-1 (CD90) expression in orbital fibroblasts of patients with Graves' ophthalmopathy. (PubMed id 18976167)1, 9 Khoo T.K....Bahn R.S. (Thyroid 2008)
    7. Characterization of alphaX I-domain binding to Thy-1. (PubMed id 15850796)1, 9 Choi J....Nham S.U. (Biochem. Biophys. Res. Commun. 2005)
    8. Human Thy-1 (CD90) on activated endothelial cells is a counterreceptor for the leukocyte integrin Mac-1 (CD11b/CD18). (PubMed id 15004192)1, 9 Wetzel A....Saalbach A. (J. Immunol. 2004)
    9. Thy-1 regulates fibroblast focal adhesions, cytoskeletal organization and migration through modulation of p190 RhoGAP and Rho GTPase activity. (PubMed id 15093746)1, 9 Barker T.H....Hagood J.S. (Exp. Cell Res. 2004)
    10. Interaction of human Thy-1 (CD 90) with the integrin alphavbeta3 (CD51/CD61): an important mechanism mediating melanoma cell adhesion to activated endothelium. (PubMed id 15897908)1, 9 Saalbach A....Anderegg U. (Oncogene 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 7070 HGNC: 11801 AceView: THY1 Ensembl:ENSG00000154096 euGenes: HUgn7070
    ECgene: THY1 Kegg: 7070 H-InvDB: THY1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for THY1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for THY1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for THY1 gene:
    Search GeneIP for patents involving THY1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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