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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

THY1 Gene

protein-coding   GIFtS: 63
GCID: GC11M119288

Thy-1 cell surface antigen
 Explore 54 diseases affiliated with
THY1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for THY1    

Aliases
for THY1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Thy-1 Cell Surface Antigen1 2     Thy-1 Membrane Glycoprotein2
CD901 2     Thy-1 T-Cell Antigen2
Thy-1 Antigen2 3     CD90 Antigen3
CDw902 3     

External Ids:    HGNC: 118011   Entrez Gene: 70702   Ensembl: ENSG000001540967   OMIM: 1882305   UniProtKB: P042163   

Export aliases for THY1 gene to outside databases

Previous GC identifers: GC11M121288 GC11M120800 GC11M119322 GC11M118826 GC11M118795 GC11M115230


Summaries
for THY1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: THY1_HUMAN, P04216
Function: May play a role in cell-cell or cell-ligand interactions during synaptogenesis and other events in the brain

Gene Wiki entry for THY1 (CD90)


Genomic Views
for THY1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.1  NT_033899.8  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the THY1 gene promoter:
         c-Fos   p53   AP-1   GR-beta   ATF-2   STAT3   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 5): THY1 promoter sequence
   Search SABiosciences Chromatin IP Primers for THY1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat THY1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q23.3   Ensembl cytogenetic band:  11q23.3   HGNC cytogenetic band: 11q23.3

THY1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
THY1 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M119288:  view genomic region     (about GC identifiers)

Start:
 119,288,090 bp from pter      End:
 119,295,695 bp from pter
Size:
 7,606 bases      Orientation:
 minus strand

Proteins
for THY1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: THY1_HUMAN, P04216 (See protein sequence)
Recommended Name: Thy-1 membrane glycoprotein precursor  
Size: 161 amino acids; 17935 Da
Subcellular location: Cell membrane; Lipid-anchor, GPI-anchor (By similarity)
Secondary accessions: Q16008 Q9NSP1

Explore the universe of human proteins at neXtProt for THY1: NX_P04216

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P04216

    • THY1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_006279.2  
    ENSEMBL proteins: 
     ENSP00000284240   ENSP00000431301   ENSP00000432051   ENSP00000432808   ENSP00000464248  
     ENSP00000435753  

    Human Recombinant Protein Products: 
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    Enzo Life Sciences proteins for THY1
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    OriGene Protein Over-expression Lysate: THY1
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    GenScript Custom Purified and Recombinant Proteins Services for THY1
    Novus Biologicals THY1 Proteins
    Novus Biologicals THY1 Lysates
    Sino Biological Recombinant Protein for THY1
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Uscn

    Gene Ontology (GO): 5/12 cellular component terms (GO ID links to tree view) (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005783endoplasmic reticulum IDA--
    GO:0005829cytosol IEA--
    GO:0005886plasma membrane ISS--
    GO:0005887integral to plasma membrane TAS2864289
    GO:0009897external side of plasma membrane ISS--


    THY1 for ontologies           About GeneDecksing



    THY1 Antibody Products: 
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    R&D Systems Antibodies for THY1 (CD90/Thy1)
    Cell Signaling Technology (CST) Antibodies for THY1 
    OriGene Antibodies (see all 5): THY1
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    GenScript Custom Superior Antibodies Services for THY1
    Novus Biologicals THY1 Antibodies
    Abcam antibodies for THY1 
    Browse Antibodies at Uscn
    ThermoFisher Antibody for THY1

    Assay Products for THY1: 
    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for THY1
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs and CLIAs at Uscn

    Protein Domains /
    Families
    for THY1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    THY1 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR007110 Ig-like_dom
     IPR003599 Ig_sub
     IPR013783 Ig-like_fold
     IPR013151 Immunoglobulin

    Graphical View of Domain Structure for InterPro Entry P04216

    ProtoNet protein and cluster: P04216

    1 Blocks protein family: IPB003599 Immunoglobulin subtype

    UniProtKB/Swiss-Prot: THY1_HUMAN, P04216
    Similarity: Contains 1 Ig-like V-type (immunoglobulin-like) domain


    Function
    for THY1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: THY1_HUMAN, P04216
    Function: May play a role in cell-cell or cell-ligand interactions during synaptogenesis and other events in the brain

         Genatlas biochemistry entry for THY1:
    Thy-1 cell surface antigen

    miRNA
    Products:            		 OriGene 3'-UTR Clone: THY1
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat THY1
    8/16 QIAGEN miScript miRNA Assays for microRNAs that regulate THY1 (see all 16):
    hsa-miR-4291 hsa-miR-125a-5p hsa-miR-4300 hsa-miR-875-3p hsa-miR-922 hsa-miR-4328 hsa-miR-520a-5p hsa-miR-103a
    SwitchGear 3'UTR luciferase reporter plasmid: THY1 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for THY1 (see all 7)
    OriGene shRNA RFP: THY1
    OriGene siRNA: THY1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat THY1

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for THY1

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for THY1 (see all 3)
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    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: THY1 (NM_006288)
    Sino Biological Human cDNA Clone for THY1
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat THY1 

    Cell Line
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    Search LifeMap BioReagents cell lines for THY1

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for THY1

    Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005100Rho GTPase activator activity ISS--
    GO:0005178integrin binding IPI15004192
    GO:0005515protein binding IPI7513706
    GO:0019899enzyme binding ----
    GO:0019901protein kinase binding IEA--


    THY1 for ontologies           About GeneDecksing


    3 GenomeRNAi human phenotypes for THY1:
     Decreased number of cells in m  Increased gamma-H2AX phosphory  Synthetic lethal with c-Myc af 

    Animal Models:
         Mouse knock-outs for THY1: Thy1tm1Kak Thy1tm1Rjmo
         3 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Thy1):
     nervous system  normal  respiratory system 

    THY1 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for THY1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/8 super-pathways (see all 8) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Neuroscience
    		Neuroscience1.00
    2Lymphocyte Signaling
    		Lymphocyte Signaling1.00
    3Adhesion
    		Adhesion1.00
    4Selected targets of Oct-3/4
    		Selected targets of Oct-3/41.00
    5amb2 Integrin signaling
    		amb2 Integrin signaling1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for THY1
        Selected targets of Oct-3/4

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for THY1
        Transendothelial Migration of Leukocytes

    3 Cell Signaling Technology (CST) Pathways for THY1
        Neuroscience
    Lymphocyte Signaling
    Adhesion

    2 BioSystems Pathways for THY1 
        amb2 Integrin signaling
    IL4-mediated signaling events


    1         Kegg Pathway  (Kegg details for THY1):
        Leukocyte transendothelial migration


    THY1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for THY1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 12)

    5/16 Interacting proteins for THY1 (P042162, 3 ENSP000002842404) via UniProtKB, MINT, STRING, and/or I2D (see all 16)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FYNP062413, ENSP000003576564I2D: score=3 STRING: ENSP00000357656
    LCKP062393, ENSP000003378254I2D: score=3 STRING: ENSP00000337825
    ITGAVP067563, ENSP000002610234I2D: score=2 STRING: ENSP00000261023
    ITGAMP112153, ENSP000002874974I2D: score=1 STRING: ENSP00000287497
    ITGB3P051063, ENSP000002620174I2D: score=1 STRING: ENSP00000262017
    About this table

    Gene Ontology (GO): 5/14 biological process terms (GO ID links to tree view) (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001525angiogenesis ISS--
    GO:0006469negative regulation of protein kinase activity ISS--
    GO:0007010cytoskeleton organization ISS--
    GO:0016337cell-cell adhesion ISS--
    GO:0030336negative regulation of cell migration ISS--


    THY1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for THY1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    THY1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for THY1
    2 Novoseek chemical compound relationships for THY1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lipid 0 5 17027000 (3), 15093746 (1)
    tyrosine 0 2 15093746 (1)

    Search CenterWatch for drugs/clinical trials and news about THY1 

    Transcripts
    for THY1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for THY1 gene: 
    NM_006288.3  

    Unigene Cluster for THY1:

    Thy-1 cell surface antigen
    Hs.644697  [show with all ESTs]
    Unigene Representative Sequence: AK090996
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000284240(uc001pwr.3) ENST00000584021 ENST00000528522 ENST00000528295
    ENST00000527590 ENST00000524970 ENST00000580275 ENST00000524659 ENST00000532974
    ENST00000533840

    miRNA
    Products:             		 OriGene 3'-UTR Clone: THY1
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat THY1
    8/16 QIAGEN miScript miRNA Assays for microRNAs that regulate THY1 (see all 16):
    hsa-miR-4291 hsa-miR-125a-5p hsa-miR-4300 hsa-miR-875-3p hsa-miR-922 hsa-miR-4328 hsa-miR-520a-5p hsa-miR-103a
    SwitchGear 3'UTR luciferase reporter plasmid: THY1 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for THY1 (see all 7)
    OriGene shRNA RFP: THY1
    OriGene siRNA: THY1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat THY1
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for THY1 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for THY1
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: THY1 (NM_006288)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for THY1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat THY1 
    Primer
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    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat THY1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat THY1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat THY1

    Additional cDNA sequence: 

    AF261093.1 AK057865.1 AK090644.1 AK090996.1 AK094374.1 AK314018.1 AL161958.1 BC005175.2 
    BC037832.1 BC065559.1 S59749.1 

    24/35 DOTS entries (see all 35):

    DT.100879495  DT.449730  DT.100879521  DT.100879522  DT.100879501  DT.100879500  DT.91734104  DT.95374065 
    DT.100879515  DT.100879514  DT.100879505  DT.97786623  DT.120730329  DT.102835886  DT.95374052  DT.92452338 
    DT.120730315  DT.100648633  DT.95374053  DT.100879494  DT.95374068  DT.97776373  DT.100723539  DT.100811997 

    24/719 AceView cDNA sequences (see all 719):

    BE552202 BX324914 BM670838 BC065559 BU615479 CB153181 CR604314 CF529916 
    AA331303 AA419091 CR610225 AA350961 CR614097 AI969617 CR620763 AI679251 
    BM704951 BQ721506 CB155258 BF445667 AI287381 AA376089 BX463537 AA902143 

    GeneLoc Exon Structure

    5/12 Alternative Splicing Database (ASD) splice patterns (SP) for THY1 (see all 12)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c · 6d ^ 7 ^ 8a · 8b · 8c · 8d ^ 9a · 9b · 9c
    SP1:                          -     -           -     -                                                                     
    SP2:                          -                 -     -                                                                     
    SP3:        -     -     -     -     -           -     -                                                                     
    SP4:                          -     -           -     -                                                                     
    SP5:                          -     -           -     -     -     -                                                         


    ECgene alternative splicing isoforms for THY1

    Expression
    for THY1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    THY1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GAGTGAGACC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    THY1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    8 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    BloodPeripheral BloodB-cell Progenitor CellsBlood
    BoneBone MarrowHematopoietic Stem CellsBlood
    LiverLiver BudHematopoietic Stem CellsBlood
    Umbilical CordWharton's JellyUmbilical Cord Mesenchymal Stem CellsExtraembryonic Tissues, Umbilical Cord
    BoneZeugopod Epiphyseal EndChondrocytesBone, Cartilage
    KidneyMetanephrosKidney
    Lower Urinary TractUreterLower Urinary Tract
    Neural TubeTelencephalonNeural Tube
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 10/34 LifeMap Cells (see all 34) 
    NameCategory
    Human multipotent adipose-derived (hMAD) stem cells (Adult Stem / Progenitor Cell)Adipose
    Adipose-derived mesenchymal stem cells (Adult Stem / Progenitor Cell)Adipose
    Peripheral blood/mobilized hematopoietic stem cells (Adult Stem / Progenitor Cell)Blood
    Placenta-derived mesenchymal stem cells (Fetal Stem / Progenitor Cell)Adipose, Bone, Cartilage, Extraembryonic Tissues
    Bone marrow-derived adherent progenitor cells (MultiStem) (Adult Stem / Progenitor Cell)Bone
    Bone marrow-derived mesenchymal stem cells and myocytes (Ixmyelocel-T) (Adult Stem / Progenitor Cell)Bone
    Human bone marrow-derived mesenchymal stem cells (Adult Stem / Progenitor Cell)Bone
    Mesenchymal stem cell (Adult Stem / Progenitor Cell)Bone
    Hematopoietic stem cells (Umbilical Cord) (Fetal Stem / Progenitor Cell)Blood, Extraembryonic Tissues
    AS034 (Embryonic Stem Cell)Early Embryo, Inner Cell Mass

    See THY1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for THY1

    SOURCE GeneReport for Unigene cluster: Hs.644697
        SABiosciences Expression via Pathway-Focused PCR Arrays including THY1: 
              Mesenchymal Stem Cell in human mouse rat
              T-cell & B-cell Activation in human mouse rat

    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat THY1
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for THY1

    Orthologs
    for THY1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for THY1 gene from 3/9 species (see all 9)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Thy11 , 5 thymus cell antigen 1, theta1, 5 76.81(n)1
    70.19(a)1    		   9 (24.52 cM)5
    218381  NM_009382.31  NP_033408.11 
     440433845 
    chicken
    (Gallus gallus)    		 Aves THY11 Thy-1 cell surface antigen 65.83(n)
    54.37(a)    		   378897  NM_204381.1  NP_989712.1 
    lizard
    (Anolis carolinensis)    		 Reptilia THY16
    		 --
    		 46(a)
    		 1 ↔ 1
    		 GL344636.1(20432-22821)


    ENSEMBL Gene Tree for THY1 (if available)
    TreeFam Gene Tree for THY1 (if available) 

    Paralogs
    for THY1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    		  --

    Genomic Variants
    for THY1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/177 NCBI SNPs in THY1 are shown (see all 177)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 11 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1417513161,2
    		--119288242(+) CTGACA/TCTGAC 2 -- int1 ds50010--------
    rs1501636991,2
    		--119288312(+) CGCTTC/TCATTT 2 -- ds5001 int10--------
    rs1387830911,2
    		--119288345(+) CCAGGG/TATGGG 2 -- ds5001 int10--------
    rs340247121,2
    		C,--119288533(+) AGAAG-/AAAAAA 2 -- ds5001 int10--------
    rs455054911,2
    		C--119288536(+) GAAGA-/AAAAAG 2 -- ds5001 int12Minor allele frequency- A:0.12NS NA 42
    rs601293251,2
    		C,--119288560(+) TTAGCG/ACAGAT 2 -- ds5001 int11Minor allele frequency- A:0.50WA 2
    rs779354471,2
    		C,--119288561(+) TAGCGC/TAGATT 2 -- int1 ds50012Minor allele frequency- T:0.12WA 120
    rs1832020271,2
    		--119288569(+) ATTCAC/TGCAAA 2 -- int1 ds50010--------
    rs1864579401,2
    		--119288581(+) CCACTA/TGTGCA 2 -- ds5001 int10--------
    rs782106081,2
    		F,--119288611(+) TGGTTC/TGGCCC 2 -- int1 ds50011Minor allele frequency- T:0.02WA 118

    HapMap Linkage Disequilibrium report for THY1 (119288090 - 119295695 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for THY1: --

    SABiosciences Cancer Mutation PCR Assays
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    Disorders / Diseases
    for THY1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    THY1 for disorders           About GeneDecksing

    OMIM gene information: 188230    OMIM disorders: --

    20/54 diseases for THY1 (see all 54):    About MalaCards
    pre-b-cell acute lymphoblastic leukemia    hypersensitivity reaction type ii disease    central retinal artery occlusion    mesangial proliferative glomerulonephritis
    retinal artery occlusion    age related macular degeneration    proliferative glomerulonephritis    mast cell neoplasm
    mycosis fungoides    acute lymphoblastic leukemia    macular degeneration    lymphoblastic leukemia
    warthin tumor    myeloid leukemia    listeriosis    cytomegalovirus infection
    atopic dermatitis    chronic myeloid leukemia    acute myeloid leukemia    glomerulonephritis

    10 Novoseek disease relationships for THY1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    proliferative nephritis 70.9 2 1724021 (1), 8651905 (1)
    lymphoblastic leukemia acute 26.9 1 9695410 (1)
    thymoma 23.2 1 7818491 (1)
    acute leukemia 21 4 9401277 (1), 8547671 (1)
    cancer 5.41 2 10791904 (1)
    inflammation 0 1 17621180 (1)
    lymphoma non-hodgkins 0 2 10791904 (1)
    tumors 0 8 12392158 (4), 12781446 (2), 16255990 (1)
    melanoma 0 8 15897908 (5), 10571119 (1)
    solid tumor 0 1 2330681 (1)

    Genetic Association Database (GAD): THY1
    Human Genome Epidemiology (HuGE) Navigator: THY1 (2 documents)
    Tumor Gene Database (TGDB): THY1

    Export disorders for THY1 gene to outside databases

    Publications
    for THY1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for THY1 gene, integrated from 9 sources (see all 166):
    (articles sorted by number of sources associating them with THY1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The human Thy-1 gene: structure and chromosomal location. (PubMed id 2864690)1, 2, 3 Seki T.... Silver J. (1985)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. cDNA cloning by amplification of circularized first strand cDNAs reveals non-IRE-regulated iron-responsive mRNAs. (PubMed id 10944468)1, 2 Ye Z. and Connor J.R. (2000)
    4. Expression of Thy-1 on human hematopoietic progenitor cells. (PubMed id 7683034)1, 2 Craig W.... Lansdorp P.M. (1993)
    5. Evidence for enhanced Thy-1 (CD90) expression in orbital fibroblasts of patients with Graves' ophthalmopathy. (PubMed id 18976167)1, 9 Khoo T.K....Bahn R.S. (2008)
    6. Characterization of alphaX I-domain binding to Thy-1. (PubMed id 15850796)1, 9 Choi J....Nham S.U. (2005)
    7. Human Thy-1 (CD90) on activated endothelial cells is a counterreceptor for the leukocyte integrin Mac-1 (CD11b/CD18). (PubMed id 15004192)1, 9 Wetzel A....Saalbach A. (2004)
    8. Thy-1 regulates fibroblast focal adhesions, cytoskeletal organization and migration through modulation of p190 RhoGAP and Rho GTPase activity. (PubMed id 15093746)1, 9 Barker T.H....Hagood J.S. (2004)
    9. Interaction of human Thy-1 (CD 90) with the integrin alphavbeta3 (CD51/CD61): an important mechanism mediating melanoma cell adhesion to activated endothelium. (PubMed id 15897908)1, 9 Saalbach A....Anderegg U. (2005)
    10. THY1 expression is associated with tumor suppression of human ovarian cancer. (PubMed id 12781446)1, 9 Abeysinghe H.R....Wang N. (2003)

    External Searches for THY1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing THY1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7070 HGNC: 11801 AceView: THY1 Ensembl:ENSG00000154096 euGenes: HUgn7070
    ECgene: THY1 Kegg: 7070 H-InvDB: THY1

    Other Databases showing THY1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing THY1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for THY1 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for THY1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for THY1 gene:
    Search GeneIP for patents involving THY1

    GeneCards and IP:
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