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Aliases for THUMPD3 Gene

Aliases for THUMPD3 Gene

  • THUMP Domain Containing 3 2 3 5

External Ids for THUMPD3 Gene

Previous GeneCards Identifiers for THUMPD3 Gene

  • GC03P009380
  • GC03P009381
  • GC03P009341
  • GC03P009405
  • GC03P009406
  • GC03P009407
  • GC03P009408
  • GC03P009409
  • GC03P009410
  • GC03P009412

Summaries for THUMPD3 Gene

GeneCards Summary for THUMPD3 Gene

THUMPD3 (THUMP Domain Containing 3) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include RNA binding and methyltransferase activity. An important paralog of this gene is THUMPD2.

Additional gene information for THUMPD3 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for THUMPD3 Gene

Genomics for THUMPD3 Gene

GeneHancer (GH) Regulatory Elements for THUMPD3 Gene

Promoters and enhancers for THUMPD3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03I009362 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 562.6 +0.4 360 2.2 MLX FEZF1 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 NFYC SRGAP3 THUMPD3 ENSG00000254485 GC03M009360 THUMPD3-AS1 RAD18 BRPF1 SETD5 TTLL3 FANCD2
GH03I009394 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 20.6 +36.1 36149 9.8 CLOCK MLX FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SETD5 THUMPD3-AS1 GC03P009403 BRPF1 RAD18 GHRLOS TTLL3 FANCD2 JAGN1 SEC13
GH03I008496 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 12 -860.4 -860391 11 HDGF PKNOX1 FOXA2 ARID4B SIN3A FEZF1 DMAP1 ZNF2 IRF4 YY1 LMCD1 SETD5 RAD18 LMCD1-AS1 THUMPD3 PIR52959
GH03I009648 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 12 +286.9 286948 2.2 HDGF PKNOX1 CLOCK FOXA2 MLX ARNT ARID4B SIN3A ZNF2 IRF4 MTMR14 BRPF1 SETD5 RAD18 JAGN1 THUMPD3 GHRLOS RPUSD3 FANCD2 SEC13
GH03I009932 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 11.9 +570.7 570734 3 HDGF MLX ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZBTB7B YY1 CRELD1 RAD18 BRPF1 SETD5 THUMPD3 ENSG00000269886 THUMPD3-AS1 FANCD2OS GC03M009919 RNU6-882P
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around THUMPD3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the THUMPD3 gene promoter:

Genomic Locations for THUMPD3 Gene

Genomic Locations for THUMPD3 Gene
chr3:9,362,842-9,386,791
(GRCh38/hg38)
Size:
23,950 bases
Orientation:
Plus strand
chr3:9,404,526-9,428,475
(GRCh37/hg19)

Genomic View for THUMPD3 Gene

Genes around THUMPD3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
THUMPD3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for THUMPD3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for THUMPD3 Gene

Proteins for THUMPD3 Gene

  • Protein details for THUMPD3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BV44-THUM3_HUMAN
    Recommended name:
    THUMP domain-containing protein 3
    Protein Accession:
    Q9BV44
    Secondary Accessions:
    • Q9H8V6
    • Q9NVC1
    • Q9UFS3

    Protein attributes for THUMPD3 Gene

    Size:
    507 amino acids
    Molecular mass:
    57003 Da
    Quaternary structure:
    No Data Available

neXtProt entry for THUMPD3 Gene

Post-translational modifications for THUMPD3 Gene

  • Ubiquitination at posLast=369369, isoforms=376, isoforms=411, and posLast=449449

No data available for DME Specific Peptides for THUMPD3 Gene

Domains & Families for THUMPD3 Gene

Gene Families for THUMPD3 Gene

Protein Domains for THUMPD3 Gene

Suggested Antigen Peptide Sequences for THUMPD3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BV44

UniProtKB/Swiss-Prot:

THUM3_HUMAN :
  • Belongs to the methyltransferase superfamily.
Family:
  • Belongs to the methyltransferase superfamily.
genes like me logo Genes that share domains with THUMPD3: view

Function for THUMPD3 Gene

Phenotypes From GWAS Catalog for THUMPD3 Gene

Gene Ontology (GO) - Molecular Function for THUMPD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IEA --
GO:0008168 methyltransferase activity IEA --
GO:0016423 tRNA (guanine) methyltransferase activity IBA --
GO:0016740 transferase activity IEA --
genes like me logo Genes that share ontologies with THUMPD3: view

Phenotypes for THUMPD3 Gene

genes like me logo Genes that share phenotypes with THUMPD3: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for THUMPD3 Gene

Localization for THUMPD3 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for THUMPD3 gene
Compartment Confidence
nucleus 5
cytosol 5
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoli (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for THUMPD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005730 nucleolus IDA --
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with THUMPD3: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for THUMPD3 Gene

Pathways & Interactions for THUMPD3 Gene

SuperPathways for THUMPD3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for THUMPD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030488 tRNA methylation IBA --
GO:0032259 methylation IEA --
genes like me logo Genes that share ontologies with THUMPD3: view

No data available for Pathways by source and SIGNOR curated interactions for THUMPD3 Gene

Drugs & Compounds for THUMPD3 Gene

No Compound Related Data Available

Transcripts for THUMPD3 Gene

Unigene Clusters for THUMPD3 Gene

THUMP domain containing 3:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for THUMPD3 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b ^
SP1: - - -
SP2: - - - - -
SP3:
SP4: - - - - - -
SP5: - - - -
SP6: - - - -
SP7: - - -
SP8:
SP9: - - - -
SP10: - - - - -
SP11: - -
SP12:

ExUns: 13
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:

Relevant External Links for THUMPD3 Gene

GeneLoc Exon Structure for
THUMPD3
ECgene alternative splicing isoforms for
THUMPD3

Expression for THUMPD3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for THUMPD3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for THUMPD3 Gene

This gene is overexpressed in Testis (21.8) and Lung (11.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for THUMPD3 Gene



Protein tissue co-expression partners for THUMPD3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of THUMPD3 Gene:

THUMPD3

SOURCE GeneReport for Unigene cluster for THUMPD3 Gene:

Hs.443081

Evidence on tissue expression from TISSUES for THUMPD3 Gene

  • Liver(4.2)
  • Eye(4.1)
  • Nervous system(3)
genes like me logo Genes that share expression patterns with THUMPD3: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for THUMPD3 Gene

Orthologs for THUMPD3 Gene

This gene was present in the common ancestor of animals.

Orthologs for THUMPD3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia THUMPD3 33 34
  • 99.3 (n)
dog
(Canis familiaris)
Mammalia THUMPD3 33 34
  • 90.04 (n)
-- 34
  • 82 (a)
OneToMany
cow
(Bos Taurus)
Mammalia THUMPD3 33 34
  • 88.51 (n)
mouse
(Mus musculus)
Mammalia Thumpd3 33 16 34
  • 84.2 (n)
rat
(Rattus norvegicus)
Mammalia Thumpd3 33
  • 83.5 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 69 (a)
OneToMany
-- 34
  • 57 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia THUMPD3 34
  • 63 (a)
OneToOne
chicken
(Gallus gallus)
Aves THUMPD3 33 34
  • 69.41 (n)
lizard
(Anolis carolinensis)
Reptilia THUMPD3 34
  • 60 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia thumpd3 33
  • 63.3 (n)
zebrafish
(Danio rerio)
Actinopterygii thumpd3 33 34
  • 60.89 (n)
worm
(Caenorhabditis elegans)
Secernentea CELE_M04B2.2 33
  • 49.78 (n)
M04B2.2 34
  • 39 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 44 (a)
OneToMany
Species where no ortholog for THUMPD3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for THUMPD3 Gene

ENSEMBL:
Gene Tree for THUMPD3 (if available)
TreeFam:
Gene Tree for THUMPD3 (if available)

Paralogs for THUMPD3 Gene

Paralogs for THUMPD3 Gene

Pseudogenes.org Pseudogenes for THUMPD3 Gene

genes like me logo Genes that share paralogs with THUMPD3: view

Variants for THUMPD3 Gene

Sequence variations from dbSNP and Humsavar for THUMPD3 Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1000024181 -- 9,363,348(+) T/A 5_prime_UTR_variant, genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000049842 -- 9,362,763(+) A/T upstream_transcript_variant
rs1000469328 -- 9,370,661(+) G/T intron_variant
rs1000479284 -- 9,375,842(+) T/C intron_variant
rs1000636378 -- 9,364,644(+) G/A/T intron_variant

Variation tolerance for THUMPD3 Gene

Residual Variation Intolerance Score: 77.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.73; 73.29% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for THUMPD3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
THUMPD3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for THUMPD3 Gene

Disorders for THUMPD3 Gene

Additional Disease Information for THUMPD3

No disorders were found for THUMPD3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for THUMPD3 Gene

Publications for THUMPD3 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal KB … Olsen JV (Science signaling 2015) 3 58

Products for THUMPD3 Gene

Sources for THUMPD3 Gene

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