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Aliases for THUMPD3 Gene

Aliases for THUMPD3 Gene

  • THUMP Domain Containing 3 2 3 5

External Ids for THUMPD3 Gene

Previous GeneCards Identifiers for THUMPD3 Gene

  • GC03P009380
  • GC03P009381
  • GC03P009341
  • GC03P009405
  • GC03P009406
  • GC03P009407
  • GC03P009408
  • GC03P009409
  • GC03P009410
  • GC03P009412

Summaries for THUMPD3 Gene

GeneCards Summary for THUMPD3 Gene

THUMPD3 (THUMP Domain Containing 3) is a Protein Coding gene. GO annotations related to this gene include RNA binding and methyltransferase activity. An important paralog of this gene is THUMPD2.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for THUMPD3 Gene

Genomics for THUMPD3 Gene

Regulatory Elements for THUMPD3 Gene

Enhancers for THUMPD3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03G009389 0.8 dbSUPER 22.7 +24.1 24071 3.5 BRD4 CTCF ESRRA FOXA2 RARA POLR2A SCRT2 KDM5B BCLAF1 SCRT1 THUMPD3 THUMPD3-AS1 SRGAP3 ENSG00000254485 SETD5
GH03G009383 0.7 dbSUPER 23 +22.2 22151 2.3 ZSCAN5A ZNF792 ZNF384 CHD7 POLR2A SCRT2 ZNF600 PRDM10 PAF1 ZNF362 THUMPD3 THUMPD3-AS1 SRGAP3 ENSG00000254485 SETD5
GH03G009381 1.4 FANTOM5 dbSUPER 11.3 +18.6 18640 0.4 HDGF PKNOX1 FOXA2 ARNT CREB3L1 MLX ARID4B SIN3A DMAP1 FEZF1 THUMPD3-AS1 THUMPD3 SETD5 RAD18 ENSG00000254485
GH03G009362 1.2 ENCODE 12.6 +0.4 361 2.2 MLX CREB3L1 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC RAD18 THUMPD3-AS1 SRGAP3 FANCD2 LINC00852 THUMPD3 GHRLOS SETD5 PRRT3-AS1 ENSG00000254485
GH03G009385 0.6 dbSUPER 22.7 +22.9 22898 1.2 ZNF740 POLR2H POLR2A SCRT2 FOXJ2 KDM5B SUPT5H RBFOX2 THUMPD3 ENSG00000254485 SRGAP3 SETD5
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around THUMPD3 on UCSC Golden Path with GeneCards custom track

Promoters for THUMPD3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000148272 158 1601 MLX CREB3L1 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC

Genomic Location for THUMPD3 Gene

Chromosome:
3
Start:
9,362,842 bp from pter
End:
9,386,791 bp from pter
Size:
23,950 bases
Orientation:
Plus strand

Genomic View for THUMPD3 Gene

Genes around THUMPD3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
THUMPD3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for THUMPD3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for THUMPD3 Gene

Proteins for THUMPD3 Gene

  • Protein details for THUMPD3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BV44-THUM3_HUMAN
    Recommended name:
    THUMP domain-containing protein 3
    Protein Accession:
    Q9BV44
    Secondary Accessions:
    • Q9H8V6
    • Q9NVC1
    • Q9UFS3

    Protein attributes for THUMPD3 Gene

    Size:
    507 amino acids
    Molecular mass:
    57003 Da
    Quaternary structure:
    No Data Available

neXtProt entry for THUMPD3 Gene

Post-translational modifications for THUMPD3 Gene

  • Ubiquitination at Lys369, Lys376, Lys411, and posLast=449449
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for THUMPD3 Gene

Domains & Families for THUMPD3 Gene

Protein Domains for THUMPD3 Gene

Suggested Antigen Peptide Sequences for THUMPD3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BV44

UniProtKB/Swiss-Prot:

THUM3_HUMAN :
  • Belongs to the methyltransferase superfamily.
Family:
  • Belongs to the methyltransferase superfamily.
genes like me logo Genes that share domains with THUMPD3: view

Function for THUMPD3 Gene

Gene Ontology (GO) - Molecular Function for THUMPD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IEA --
GO:0008168 methyltransferase activity IEA --
GO:0016740 transferase activity IEA --
genes like me logo Genes that share ontologies with THUMPD3: view

Phenotypes for THUMPD3 Gene

genes like me logo Genes that share phenotypes with THUMPD3: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for THUMPD3 Gene

Localization for THUMPD3 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for THUMPD3 gene
Compartment Confidence
nucleus 5
cytosol 5
mitochondrion 1

Gene Ontology (GO) - Cellular Components for THUMPD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005730 nucleolus IDA --
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with THUMPD3: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for THUMPD3 Gene

Pathways & Interactions for THUMPD3 Gene

SuperPathways for THUMPD3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for THUMPD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0032259 methylation IEA --
genes like me logo Genes that share ontologies with THUMPD3: view

No data available for Pathways by source and SIGNOR curated interactions for THUMPD3 Gene

Transcripts for THUMPD3 Gene

Unigene Clusters for THUMPD3 Gene

THUMP domain containing 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for THUMPD3 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b ^
SP1: - - -
SP2: - - - - -
SP3:
SP4: - - - - - -
SP5: - - - -
SP6: - - - -
SP7: - - -
SP8:
SP9: - - - -
SP10: - - - - -
SP11: - -
SP12:

ExUns: 13
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:

Relevant External Links for THUMPD3 Gene

GeneLoc Exon Structure for
THUMPD3
ECgene alternative splicing isoforms for
THUMPD3

Expression for THUMPD3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for THUMPD3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for THUMPD3 Gene

This gene is overexpressed in Testis (21.8) and Lung (11.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for THUMPD3 Gene



Protein tissue co-expression partners for THUMPD3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of THUMPD3 Gene:

THUMPD3

SOURCE GeneReport for Unigene cluster for THUMPD3 Gene:

Hs.443081

Evidence on tissue expression from TISSUES for THUMPD3 Gene

  • Liver(4.2)
  • Eye(4.1)
  • Nervous system(3)
genes like me logo Genes that share expression patterns with THUMPD3: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for THUMPD3 Gene

Orthologs for THUMPD3 Gene

This gene was present in the common ancestor of animals.

Orthologs for THUMPD3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia THUMPD3 34 35
  • 99.3 (n)
dog
(Canis familiaris)
Mammalia THUMPD3 34 35
  • 90.04 (n)
-- 35
  • 82 (a)
OneToMany
cow
(Bos Taurus)
Mammalia THUMPD3 34 35
  • 88.51 (n)
mouse
(Mus musculus)
Mammalia Thumpd3 34 16 35
  • 84.2 (n)
rat
(Rattus norvegicus)
Mammalia Thumpd3 34
  • 83.5 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 69 (a)
OneToMany
-- 35
  • 57 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia THUMPD3 35
  • 63 (a)
OneToOne
chicken
(Gallus gallus)
Aves THUMPD3 34 35
  • 69.41 (n)
lizard
(Anolis carolinensis)
Reptilia THUMPD3 35
  • 60 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia thumpd3 34
  • 63.3 (n)
zebrafish
(Danio rerio)
Actinopterygii thumpd3 34 35
  • 60.89 (n)
worm
(Caenorhabditis elegans)
Secernentea CELE_M04B2.2 34
  • 49.78 (n)
M04B2.2 35
  • 39 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 44 (a)
OneToMany
Species where no ortholog for THUMPD3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for THUMPD3 Gene

ENSEMBL:
Gene Tree for THUMPD3 (if available)
TreeFam:
Gene Tree for THUMPD3 (if available)

Paralogs for THUMPD3 Gene

Paralogs for THUMPD3 Gene

Pseudogenes.org Pseudogenes for THUMPD3 Gene

genes like me logo Genes that share paralogs with THUMPD3: view

Variants for THUMPD3 Gene

Sequence variations from dbSNP and Humsavar for THUMPD3 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1000024181 -- 9,363,348(+) TTTCA(A/T)TCTGC intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs1000049842 -- 9,362,763(+) CAGAA(A/T)TCAGT intron-variant, upstream-variant-2KB
rs1000469328 -- 9,370,661(+) GTCTG(G/T)TCTCA intron-variant
rs1000479284 -- 9,375,842(+) CGCAG(C/T)GGTAT intron-variant
rs1000636378 -- 9,364,644(+) GCCCA(A/G/T)CCAAG intron-variant, upstream-variant-2KB

Variation tolerance for THUMPD3 Gene

Residual Variation Intolerance Score: 77.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.73; 73.29% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for THUMPD3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
THUMPD3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for THUMPD3 Gene

Disorders for THUMPD3 Gene

Relevant External Links for THUMPD3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
THUMPD3

No disorders were found for THUMPD3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for THUMPD3 Gene

Publications for THUMPD3 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
  4. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3 64
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64

Products for THUMPD3 Gene

Sources for THUMPD3 Gene

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