THUMPD3 Gene
protein-coding GIFtS : 44
GCID: GC03 P009409
THUMP domain containing 3
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Aliasesfor THUMPD3 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases THUMP Domain Containing 3 1 2 DKFZP434F0911 THUMP Domain-Containing Protein 32
Export aliases for THUMPD3 gene to outside databases Previous GC identifers: GC03P009380 GC03P009381 GC03P009341 GC03P009405 GC03P009406 GC03P009407 GC03P009408
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Summariesfor THUMPD3 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section --
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Genomic Viewsfor THUMPD3 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000003.11 NC_018914.1 NT_022517.18 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the THUMPD3 gene promoter: SRY POU2F1 AML1a POU2F1a FOXD3 Tal-1beta E47 Other transcription factors Search SABiosciences Chromatin IP Primers for THUMPD3 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat THUMPD3
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 3p25.3 Ensembl cytogenetic band: 3p25.3 HGNC cytogenetic band: 3p25.3 THUMPD3 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 3 GeneLoc Exon Structure
GeneLoc location for GC03P009409: view genomic region
(about GC identifiers )
Start:
9,404,526 bp from pter
End:
9,428,475 bp from pter
Size:
23,950 bases
Orientation:
plus strand
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Proteinsfor THUMPD3 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: THUM3_HUMAN, Q9BV44 (See
protein sequence )Recommended Name: THUMP domain-containing protein 3 Size : 507 amino acids; 57003 Da
Secondary accessions : Q9H8V6 Q9NVC1 Q9UFS3Explore the universe of human proteins at neXtProt for THUMPD3: NX_Q9BV44 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q9BV44 THUMPD3 Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins (2 alternative transcripts):
NP_001107564.1 NP_056268.2 ENSEMBL proteins: ENSP00000395893 ENSP00000402968 ENSP00000411126 ENSP00000339532 ENSP00000424064 ENSP00000396359 ENSP00000412199 Human Recombinant Protein Products: THUMPD3 Antibody Products: Assay Products for THUMPD3:
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Protein
Domains / Familiesfor THUMPD3 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
THUMPD3 for domains About GeneDecksing 2 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry Q9BV44 ProtoNet protein and cluster: Q9BV44
1 Blocks protein family : IPB000241 Putative RNA methylase UniProtKB/Swiss-Prot: THUM3_HUMAN, Q9BV44 Similarity : Belongs to the methyltransferase superfamilySimilarity : Contains 1 THUMP domain
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Functionfor THUMPD3 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for THUMPD3 (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for THUMPD3 (see all 2 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector (see all 2 ): THUMPD3 (NM_015453 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for THUMPD3 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat THUMPD3
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for THUMPD3
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0003723 RNA binding
IEA -- GO:0008168 methyltransferase activity
IEA --
THUMPD3 for ontologies About GeneDecksing
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Pathways & Interactionsfor THUMPD3 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for THUMPD3 STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)2 Interacting proteins for THUMPD3 (Q9BV44 3 ENSP00000339532 4 ) via UniProtKB, MINT, STRING , and/or I2D About this table
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Drugs & Compoundsfor THUMPD3 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for THUMPD3 Search CenterWatch for drugs/clinical trials and news about THUMPD3 / THUM3
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Transcriptsfor THUMPD3 gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for THUMPD3 gene (2 alternative transcripts): NM_001114092.1 NM_015453.2 Unigene Cluster for THUMPD3:
THUMP domain containing 3 Hs.443081 [show with all ESTs ] Unigene Representative Sequence: NM_015453 10 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000452837 ENST00000417036 ENST00000419437 ENST00000345094 (uc003bro.4 uc003brn.4 )ENST00000515662 ENST00000441127 ENST00000416603 ENST00000461636 ENST00000484006 ENST00000464045 Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for THUMPD3 (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for THUMPD3 (see all 2 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector (see all 2 ): THUMPD3 (NM_015453 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for THUMPD3 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat THUMPD3
Additional cDNA sequence: AK001680.1 AK023263.1 AL080228.1 AL117483.1 BC001622.1 BC010421.1
20 DOTS entries : DT.95326463 DT.92440533
DT.100794654 DT.100794658 DT.100794660 DT.97847632 DT.100794659 DT.120868666 DT.120868735 DT.95326457 DT.120868904 DT.103141 DT.75188256 DT.95295460 DT.99933793 DT.120868750 DT.92440534 DT.95251487 DT.100644577 DT.86839523 24/192 AceView cDNA sequences (see all 192 ):
AA804911 AU132977 AW297128 CR615742 BG575495 BM711853 CB122170 AI337459 AA461019 AA460671 BQ271630 AI827983 CF541119 N75051 AI457532 AI332410 BM693593 AL080228 BX280227 AI972851 CR603369 BM756926 AA744910 BQ271944 GeneLoc Exon Structure 5/12 Alternative Splicing Database (ASD) splice patterns (SP) for THUMPD3 (see all 12 ) About this scheme ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b ^ SP1 :                                           -   -       -   SP2 :         -   -   -   -     -                                   SP3 :                                                     SP4 :         -   -   -   -   -   -                                   SP5 :             -   -   -   -                                  
ExUns: 13 SP1 :   SP2 :   SP3 :   SP4 :   SP5 :  
ECgene alternative splicing isoforms for THUMPD3
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Expression for THUMPD3 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section THUMPD3 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: ATAATGAAGT
About this image THUMPD3 expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table 2 LifeMap In Vivo Development Anatomical Compartments/Cells Tissue Anatomical Compartment
Cell Category (developmental path) Bone Membranous Facial Bones Bone Cartilage Chondrocranium Cartilage Expression: Positive Negative
Selective markerExperimental details:
Curated
Microarrays
In-situ hybridization
See THUMPD3 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for THUMPD3 SOURCE GeneReport for Unigene cluster: Hs.443081 SABiosciences Custom PCR Arrays for THUMPD3 Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for THUMPD3Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat THUMPD3 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat THUMPD3 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat THUMPD3 In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for THUMPD3
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Orthologsfor THUMPD3 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of animals.
Orthologs for THUMPD3 gene from 6/19 species (see all 19 ) About this table
ENSEMBL Gene Tree for THUMPD3 (if available)TreeFam Gene Tree for THUMPD3 (if available)
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Paralogsfor THUMPD3 gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for THUMPD3 gene THUMPD2 2
THUMPD3 for paralogs About GeneDecksing 1 Pseudogenes.org Pseudogene for THUMPD3 PGOHUM00000233203
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Genomic Variantsfor THUMPD3 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 3 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for THUMPD3 (9404526 - 9428475 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for THUMPD3: --
SABiosciences Cancer Mutation PCR Assays
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Disorders
/ Diseasesfor THUMPD3 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section --
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Publicationsfor THUMPD3 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for THUMPD3 gene, integrated from 9 sources (see all 12 ): (articles sorted by number of sources associating them with THUMPD3) Utopia : connect your pdf to the dynamic world of online information
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 1 , 2 Gerhard D.S....Malek J. (2004) Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039) 1 , 2 Ota T.... Sugano S. (2004) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932) 1 , 3 Strausberg R.L....Marra M.A. (2002) A census of human soluble protein complexes. (PubMed id 22939629) 1 Havugimana P.C....Emili A. (2012) Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724) 1 Udeshi N.D....Carr S.A. (2012) A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883) 1 Kristensen A.R....Foster L.J. (2012) Initial characterization of the human central proteome. (PubMed id 21269460) 2 Burkard T.R.... Colinge J. (2011) Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048) 1 Danielsen J.M....Nielsen M.L. (2011) A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473) 1 Wagner S.A....Choudhary C. (2011) The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005) 2 Bechtel S.... Schupp I. (2007)
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External Searches for THUMPD3 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing THUMPD3 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing THUMPD3 gene
(According to HUGE )
About This Section --
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Specialized Databases showing THUMPD3 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for THUMPD3 Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for THUMPD3 gene: Search GeneIP for patents involving THUMPD3 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor THUMPD3 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
Browse OriGene Antibodies OriGene shRNA RFP for THUMPD3 OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for THUMPD3 OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for THUMPD3 OriGene Protein Over-expression Lysate for THUMPD3 Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for THUMPD3 OriGene 3'-UTR Clone for THUMPD3 OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for THUMPD3 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for THUMPD3 Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs OriGene Purified Protein for THUMPD3 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for THUMPD3 OriGene Custom Protein Services for THUMPD3 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat THUMPD3 Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing THUMPD3 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat THUMPD3 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat THUMPD3 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat THUMPD3 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat THUMPD3
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THUMPD3 Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for THUMPD3
ThermoFisher Antibodies for THUMPD3
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat THUMPD3
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