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Aliases for THUMPD2 Gene

Aliases for THUMPD2 Gene

  • THUMP Domain Containing 2 2 3 5
  • C2orf8 3 4
  • Chromosome 2 Open Reading Frame 8 2
  • SAM-Dependent Methyltransferase 3

External Ids for THUMPD2 Gene

Previous HGNC Symbols for THUMPD2 Gene

  • C2orf8

Previous GeneCards Identifiers for THUMPD2 Gene

  • GC02M039938
  • GC02M039875

Summaries for THUMPD2 Gene

GeneCards Summary for THUMPD2 Gene

THUMPD2 (THUMP Domain Containing 2) is a Protein Coding gene. Diseases associated with THUMPD2 include Bejel. GO annotations related to this gene include RNA binding and methyltransferase activity. An important paralog of this gene is THUMPD3.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for THUMPD2 Gene

Genomics for THUMPD2 Gene

Regulatory Elements for THUMPD2 Gene

Enhancers for THUMPD2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around THUMPD2 on UCSC Golden Path with GeneCards custom track

Promoters for THUMPD2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around THUMPD2 on UCSC Golden Path with GeneCards custom track

Genomic Location for THUMPD2 Gene

39,736,060 bp from pter
39,779,276 bp from pter
43,217 bases
Minus strand

Genomic View for THUMPD2 Gene

Genes around THUMPD2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
THUMPD2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for THUMPD2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for THUMPD2 Gene

Proteins for THUMPD2 Gene

  • Protein details for THUMPD2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    THUMP domain-containing protein 2
    Protein Accession:
    Secondary Accessions:
    • A8K7I7
    • Q53TT8
    • Q53TV0

    Protein attributes for THUMPD2 Gene

    503 amino acids
    Molecular mass:
    56433 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH04163.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH13299.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAL26317.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAY14769.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for THUMPD2 Gene


neXtProt entry for THUMPD2 Gene

Proteomics data for THUMPD2 Gene at MOPED

Post-translational modifications for THUMPD2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for THUMPD2 Gene

Domains & Families for THUMPD2 Gene

Protein Domains for THUMPD2 Gene

Suggested Antigen Peptide Sequences for THUMPD2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 THUMP domain.
  • Belongs to the methyltransferase superfamily.
  • Contains 1 THUMP domain.
  • Belongs to the methyltransferase superfamily.
genes like me logo Genes that share domains with THUMPD2: view

No data available for Gene Families for THUMPD2 Gene

Function for THUMPD2 Gene

genes like me logo Genes that share phenotypes with THUMPD2: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for THUMPD2 Gene

Localization for THUMPD2 Gene

Subcellular locations from

Jensen Localization Image for THUMPD2 Gene COMPARTMENTS Subcellular localization image for THUMPD2 gene
Compartment Confidence
cytosol 2
nucleus 2
mitochondrion 1
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for THUMPD2 Gene

Pathways & Interactions for THUMPD2 Gene

SuperPathways for THUMPD2 Gene

No Data Available

Interacting Proteins for THUMPD2 Gene

Gene Ontology (GO) - Biological Process for THUMPD2 Gene


No data available for Pathways by source and SIGNOR curated interactions for THUMPD2 Gene

Drugs & Compounds for THUMPD2 Gene

(1) Drugs for THUMPD2 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with THUMPD2: view

Transcripts for THUMPD2 Gene

Unigene Clusters for THUMPD2 Gene

THUMP domain containing 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for THUMPD2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c
SP1: -
SP2: - -
SP3: -

Relevant External Links for THUMPD2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for THUMPD2 Gene

mRNA expression in normal human tissues for THUMPD2 Gene

Protein differential expression in normal tissues from HIPED for THUMPD2 Gene

This gene is overexpressed in Prostate (24.7), CD4 Tcells (21.1), and Ovary (13.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for THUMPD2 Gene

SOURCE GeneReport for Unigene cluster for THUMPD2 Gene Hs.468254

mRNA Expression by UniProt/SwissProt for THUMPD2 Gene

Tissue specificity: Expressed in a variety of tissues including brain, colon, gingiva, heart, kidney, liver, lung, placenta, small intestine, spleen and thymus.
genes like me logo Genes that share expression patterns with THUMPD2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Protein tissue co-expression partners for THUMPD2 Gene

Orthologs for THUMPD2 Gene

This gene was present in the common ancestor of animals.

Orthologs for THUMPD2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia THUMPD2 35
  • 83.8 (n)
  • 75.8 (a)
  • 75 (a)
(Canis familiaris)
Mammalia THUMPD2 35
  • 87.56 (n)
  • 82.83 (a)
  • 81 (a)
(Mus musculus)
Mammalia Thumpd2 35
  • 77 (n)
  • 69.2 (a)
Thumpd2 16
Thumpd2 36
  • 63 (a)
(Pan troglodytes)
Mammalia THUMPD2 35
  • 99.47 (n)
  • 99.4 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia Thumpd2 35
  • 74.67 (n)
  • 66.8 (a)
(Monodelphis domestica)
Mammalia THUMPD2 36
  • 66 (a)
(Ornithorhynchus anatinus)
Mammalia THUMPD2 36
  • 59 (a)
(Gallus gallus)
Aves THUMPD2 35
  • 63.69 (n)
  • 56.13 (a)
  • 50 (a)
(Anolis carolinensis)
Reptilia THUMPD2 36
  • 48 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia thumpd2 35
  • 56.54 (n)
  • 50.11 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.7066 35
(Danio rerio)
Actinopterygii thumpd2 35
  • 53.18 (n)
  • 42.35 (a)
thumpd2 36
  • 37 (a)
(Caenorhabditis elegans)
Secernentea M04B2.2 36
  • 22 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 24 (a)
Species with no ortholog for THUMPD2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for THUMPD2 Gene

Gene Tree for THUMPD2 (if available)
Gene Tree for THUMPD2 (if available)

Paralogs for THUMPD2 Gene

Paralogs for THUMPD2 Gene

genes like me logo Genes that share paralogs with THUMPD2: view

Variants for THUMPD2 Gene

Sequence variations from dbSNP and Humsavar for THUMPD2 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs727376 -- 39,773,347(-) CATAC(A/C)TTTTC intron-variant, upstream-variant-2KB
rs1861258 -- 39,772,666(-) GGTTG(A/T)CCCTA intron-variant, upstream-variant-2KB
rs917960 -- 39,743,243(-) TACTA(A/C)ATTGT intron-variant
rs917961 -- 39,743,228(-) CTGGG(A/C)ATTTG intron-variant
rs917962 -- 39,739,454(-) AGTGG(C/T)TACCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for THUMPD2 Gene

Variant ID Type Subtype PubMed ID
nsv833870 CNV Gain 17160897
nsv833881 CNV Loss 17160897
nsv873890 CNV Gain 21882294
nsv2696 CNV Loss 18451855

Variation tolerance for THUMPD2 Gene

Residual Variation Intolerance Score: 26% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.32; 53.39% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for THUMPD2 Gene

Disorders for THUMPD2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for THUMPD2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
  • njovera
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for THUMPD2

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with THUMPD2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for THUMPD2 Gene

Publications for THUMPD2 Gene

  1. Localization, genomic organization, and alternative transcription of a novel human SAM-dependent methyltransferase gene on chromosome 2p22-->p21. (PMID: 12063391) Zhang Y. … Hart T.C. (Cytogenet. Cell Genet. 2001) 2 3 4 23 67
  2. Characterization of the Cardiac Overexpression of HSPB2 Reveals Mitochondrial and Myogenic Roles Supported by a Cardiac HspB2 Interactome. (PMID: 26465331) Grose J.H. … Benjamin I.J. (PLoS ONE 2015) 3
  3. A census of human soluble protein complexes. (PMID: 22939629) Havugimana P.C. … Emili A. (Cell 2012) 3
  4. Genome-wide association scan for five major dimensions of personality. (PMID: 18957941) Terracciano A. … Costa P.T. (Mol. Psychiatry 2010) 3
  5. Inhibition of methylation decreases osteoblast differentiation via a non-DNA-dependent methylation mechanism. (PMID: 19815105) Vaes B.L. … Steegenga W.T. (Bone 2010) 23

Products for THUMPD2 Gene

Sources for THUMPD2 Gene