Free for academic non-profit institutions. Other users need a Commercial license

Aliases for THUMPD2 Gene

Aliases for THUMPD2 Gene

  • THUMP Domain Containing 2 2 3
  • C2orf8 3 4 6
  • Chromosome 2 Open Reading Frame 8 2
  • THUMP Domain-Containing Protein 2 3
  • SAM-Dependent Methyltransferase 3

External Ids for THUMPD2 Gene

Previous HGNC Symbols for THUMPD2 Gene

  • C2orf8

Previous GeneCards Identifiers for THUMPD2 Gene

  • GC02M039938
  • GC02M039875

Summaries for THUMPD2 Gene

GeneCards Summary for THUMPD2 Gene

THUMPD2 (THUMP Domain Containing 2) is a Protein Coding gene. GO annotations related to this gene include RNA binding and methyltransferase activity. An important paralog of this gene is THUMPD3.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for THUMPD2 Gene

Genomics for THUMPD2 Gene

Genomic Location for THUMPD2 Gene

Start:
39,736,060 bp from pter
End:
39,779,276 bp from pter
Size:
43,217 bases
Orientation:
Minus strand

Genomic View for THUMPD2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for THUMPD2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for THUMPD2 Gene

Proteins for THUMPD2 Gene

  • Protein details for THUMPD2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BTF0-THUM2_HUMAN
    Recommended name:
    THUMP domain-containing protein 2
    Protein Accession:
    Q9BTF0
    Secondary Accessions:
    • A8K7I7
    • Q53TT8
    • Q53TV0

    Protein attributes for THUMPD2 Gene

    Size:
    503 amino acids
    Molecular mass:
    56433 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH04163.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH13299.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAL26317.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAY14769.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for THUMPD2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for THUMPD2 Gene

Proteomics data for THUMPD2 Gene at MOPED

Post-translational modifications for THUMPD2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for THUMPD2 Gene

No data available for DME Specific Peptides for THUMPD2 Gene

Domains for THUMPD2 Gene

Protein Domains for THUMPD2 Gene

Suggested Antigen Peptide Sequences for THUMPD2 Gene

Graphical View of Domain Structure for InterPro Entry

Q9BTF0

UniProtKB/Swiss-Prot:

THUM2_HUMAN :
  • Q9BTF0
Domain:
  • Contains 1 THUMP domain.
Family:
  • Belongs to the methyltransferase superfamily.
genes like me logo Genes that share domains with THUMPD2: view

No data available for Gene Families for THUMPD2 Gene

Function for THUMPD2 Gene

Gene Ontology (GO) - Molecular Function for THUMPD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IEA --
GO:0008168 methyltransferase activity IEA --
genes like me logo Genes that share ontologies with THUMPD2: view

Phenotypes for THUMPD2 Gene

genes like me logo Genes that share phenotypes with THUMPD2: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for THUMPD2 Gene

Localization for THUMPD2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for THUMPD2 Gene COMPARTMENTS Subcellular localization image for THUMPD2 gene
Compartment Confidence
cytosol 2
nucleus 2
mitochondrion 1
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for THUMPD2 Gene

Pathways for THUMPD2 Gene

SuperPathways for THUMPD2 Gene

No Data Available

Interacting Proteins for THUMPD2 Gene

Gene Ontology (GO) - Biological Process for THUMPD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008152 metabolic process --
GO:0032259 methylation IEA --
genes like me logo Genes that share ontologies with THUMPD2: view

No data available for Pathways by source for THUMPD2 Gene

Compounds for THUMPD2 Gene

(1) Novoseek inferred chemical compound relationships for THUMPD2 Gene

Compound -log(P) Hits PubMed IDs
s-adenosylmethionine 80 9
genes like me logo Genes that share compounds with THUMPD2: view

Transcripts for THUMPD2 Gene

Unigene Clusters for THUMPD2 Gene

THUMP domain containing 2:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for THUMPD2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for THUMPD2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c
SP1: -
SP2: - -
SP3: -
SP4:

Relevant External Links for THUMPD2 Gene

GeneLoc Exon Structure for
THUMPD2
ECgene alternative splicing isoforms for
THUMPD2

Expression for THUMPD2 Gene

mRNA expression in normal human tissues for THUMPD2 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for THUMPD2 Gene

SOURCE GeneReport for Unigene cluster for THUMPD2 Gene Hs.468254

mRNA Expression by UniProt/SwissProt for THUMPD2 Gene

Q9BTF0-THUM2_HUMAN
Tissue specificity: Expressed in a variety of tissues including brain, colon, gingiva, heart, kidney, liver, lung, placenta, small intestine, spleen and thymus.
genes like me logo Genes that share expressions with THUMPD2: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for THUMPD2 Gene

Orthologs for THUMPD2 Gene

This gene was present in the common ancestor of animals.

Orthologs for THUMPD2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia THUMPD2 35
  • 99.47 (n)
  • 99.4 (a)
THUMPD2 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia THUMPD2 35
  • 83.8 (n)
  • 75.8 (a)
THUMPD2 36
  • 75 (a)
OneToOne
dog
(Canis familiaris)
Mammalia THUMPD2 35
  • 87.56 (n)
  • 82.83 (a)
THUMPD2 36
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Thumpd2 35
  • 77 (n)
  • 69.2 (a)
Thumpd2 16
Thumpd2 36
  • 63 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia THUMPD2 36
  • 66 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia THUMPD2 36
  • 59 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Thumpd2 35
  • 74.67 (n)
  • 66.8 (a)
chicken
(Gallus gallus)
Aves THUMPD2 35
  • 63.69 (n)
  • 56.13 (a)
THUMPD2 36
  • 50 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia THUMPD2 36
  • 48 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.7066 35
tropical clawed frog
(Silurana tropicalis)
Amphibia thumpd2 35
  • 56.54 (n)
  • 50.11 (a)
zebrafish
(Danio rerio)
Actinopterygii thumpd2 35
  • 53.18 (n)
  • 42.35 (a)
thumpd2 36
  • 37 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea M04B2.2 36
  • 22 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 24 (a)
OneToMany
Species with no ortholog for THUMPD2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for THUMPD2 Gene

ENSEMBL:
Gene Tree for THUMPD2 (if available)
TreeFam:
Gene Tree for THUMPD2 (if available)

Paralogs for THUMPD2 Gene

Paralogs for THUMPD2 Gene

genes like me logo Genes that share paralogs with THUMPD2: view

Variants for THUMPD2 Gene

Sequence variations from dbSNP and Humsavar for THUMPD2 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs3311 -- 39,736,421(+) TTAAG(A/T)GAACC utr-variant-3-prime, nc-transcript-variant, downstream-variant-500B
rs8265 -- 39,736,527(-) AGTTA(C/T)CGAAT utr-variant-3-prime, nc-transcript-variant, downstream-variant-500B
rs727376 -- 39,773,347(-) CATAC(A/C)TTTTC intron-variant, upstream-variant-2KB
rs917960 -- 39,743,243(-) TACTA(A/C)ATTGT intron-variant
rs917961 -- 39,743,228(-) CTGGG(A/C)ATTTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for THUMPD2 Gene

Variant ID Type Subtype PubMed ID
nsv833870 CNV Gain 17160897
nsv833881 CNV Loss 17160897
nsv873890 CNV Gain 21882294
nsv2696 CNV Loss 18451855

Relevant External Links for THUMPD2 Gene

HapMap Linkage Disequilibrium report
THUMPD2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for THUMPD2 Gene

Disorders for THUMPD2 Gene

(1) University of Copenhagen DISEASES for THUMPD2 Gene

Relevant External Links for THUMPD2

Genetic Association Database (GAD)
THUMPD2
genes like me logo Genes that share disorders with THUMPD2: view

No data available for UniProtKB/Swiss-Prot for THUMPD2 Gene

Publications for THUMPD2 Gene

  1. Localization, genomic organization, and alternative transcription of a novel human SAM-dependent methyltransferase gene on chromosome 2p22-->p21. (PMID: 12063391) Zhang Y. … Hart T.C. (Cytogenet. Cell Genet. 2001) 2 3 4 23
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Genome-wide association scan for five major dimensions of personality. (PMID: 18957941) Terracciano A. … Costa P.T. (Mol. Psychiatry 2010) 3 48
  5. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PMID: 21906983) Kim W. … Gygi S.P. (Mol. Cell 2011) 3

Products for THUMPD2 Gene

Sources for THUMPD2 Gene

Back to Top

Content