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Aliases for THUMPD2 Gene

Aliases for THUMPD2 Gene

  • THUMP Domain Containing 2 2 3 5
  • C2orf8 3 4
  • Chromosome 2 Open Reading Frame 8 2
  • THUMP Domain-Containing Protein 2 3
  • SAM-Dependent Methyltransferase 3

External Ids for THUMPD2 Gene

Previous HGNC Symbols for THUMPD2 Gene

  • C2orf8

Previous GeneCards Identifiers for THUMPD2 Gene

  • GC02M039938
  • GC02M039875

Summaries for THUMPD2 Gene

GeneCards Summary for THUMPD2 Gene

THUMPD2 (THUMP Domain Containing 2) is a Protein Coding gene. GO annotations related to this gene include RNA binding and methyltransferase activity. An important paralog of this gene is THUMPD3.

Additional gene information for THUMPD2 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for THUMPD2 Gene

Genomics for THUMPD2 Gene

Regulatory Elements for THUMPD2 Gene

Enhancers for THUMPD2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02H039467 1.6 Ensembl ENCODE dbSUPER 31.7 +310.1 310104 3.9 PKNOX1 ATF1 FOXA2 MLX ZNF133 ARID4B DMAP1 ZNF766 FOS CAVIN1 THUMPD2 SOS1 SRSF7 MAP4K3 DHX57 ENSG00000252473 LOC728730 TMEM178A PIR40288
GH02H039229 1.2 Ensembl ENCODE 20.9 +549.4 549382 0.9 FOXA2 ATF1 ARNT ARID4B ZNF143 MXD4 NFYC REST MIER2 PPARG THUMPD2 MAP4K3 SOS1 HNRNPLL CDKL4 GC02M039185
GH02H039150 1.1 dbSUPER 18.5 +622.8 622767 13 FOXA2 MLX ARNT ARID4B YY1 SLC30A9 ZNF766 SP5 ZHX2 ZNF592 SOS1 SRSF7 THUMPD2 ENSG00000202309 MAP4K3 ENSG00000252473 GC02M039185 GC02M039129
GH02H039782 1 Ensembl ENCODE 19.2 -4.0 -4008 0.6 PKNOX1 ZSCAN4 BACH1 RFX5 FOSL1 CTBP1 GATA3 POLR2A SCRT2 FOSL2 THUMPD2 SOS1 MAP4K3 ENSG00000252473 SLC8A1-AS1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around THUMPD2 on UCSC Golden Path with GeneCards custom track

Promoters for THUMPD2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Locations for THUMPD2 Gene

Genomic Locations for THUMPD2 Gene
43,217 bases
Minus strand

Genomic View for THUMPD2 Gene

Genes around THUMPD2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
THUMPD2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for THUMPD2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for THUMPD2 Gene

Proteins for THUMPD2 Gene

  • Protein details for THUMPD2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    THUMP domain-containing protein 2
    Protein Accession:
    Secondary Accessions:
    • A8K7I7
    • Q53TT8
    • Q53TV0

    Protein attributes for THUMPD2 Gene

    503 amino acids
    Molecular mass:
    56433 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH04163.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH13299.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAL26317.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAY14769.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for THUMPD2 Gene


neXtProt entry for THUMPD2 Gene

Post-translational modifications for THUMPD2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for THUMPD2 Gene

Domains & Families for THUMPD2 Gene

Gene Families for THUMPD2 Gene

Protein Domains for THUMPD2 Gene

Suggested Antigen Peptide Sequences for THUMPD2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the methyltransferase superfamily.
  • Belongs to the methyltransferase superfamily.
genes like me logo Genes that share domains with THUMPD2: view

Function for THUMPD2 Gene

Phenotypes From GWAS Catalog for THUMPD2 Gene

Gene Ontology (GO) - Molecular Function for THUMPD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IEA --
GO:0008168 methyltransferase activity IEA --
GO:0016423 tRNA (guanine) methyltransferase activity IBA --
GO:0016740 transferase activity IEA --
genes like me logo Genes that share ontologies with THUMPD2: view
genes like me logo Genes that share phenotypes with THUMPD2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for THUMPD2 Gene

Localization for THUMPD2 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for THUMPD2 gene
Compartment Confidence
nucleus 2
cytosol 2
mitochondrion 1
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for THUMPD2 Gene

Pathways & Interactions for THUMPD2 Gene

SuperPathways for THUMPD2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for THUMPD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030488 tRNA methylation IBA --
GO:0032259 methylation IEA --
genes like me logo Genes that share ontologies with THUMPD2: view

No data available for Pathways by source and SIGNOR curated interactions for THUMPD2 Gene

Drugs & Compounds for THUMPD2 Gene

(1) Additional Compounds for THUMPD2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with THUMPD2: view

Transcripts for THUMPD2 Gene

Unigene Clusters for THUMPD2 Gene

THUMP domain containing 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for THUMPD2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c
SP1: -
SP2: - -
SP3: -

Relevant External Links for THUMPD2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for THUMPD2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for THUMPD2 Gene

Protein differential expression in normal tissues from HIPED for THUMPD2 Gene

This gene is overexpressed in Prostate (24.7), CD4 Tcells (21.1), and Ovary (13.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for THUMPD2 Gene

NURSA nuclear receptor signaling pathways regulating expression of THUMPD2 Gene:


SOURCE GeneReport for Unigene cluster for THUMPD2 Gene:


mRNA Expression by UniProt/SwissProt for THUMPD2 Gene:

Tissue specificity: Expressed in a variety of tissues including brain, colon, gingiva, heart, kidney, liver, lung, placenta, small intestine, spleen and thymus.

Evidence on tissue expression from TISSUES for THUMPD2 Gene

  • Intestine(4.2)
  • Muscle(4.2)
genes like me logo Genes that share expression patterns with THUMPD2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for THUMPD2 Gene

Orthologs for THUMPD2 Gene

This gene was present in the common ancestor of animals.

Orthologs for THUMPD2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia THUMPD2 33 34
  • 99.47 (n)
(Canis familiaris)
Mammalia THUMPD2 33 34
  • 87.56 (n)
(Bos Taurus)
Mammalia THUMPD2 33 34
  • 83.8 (n)
(Mus musculus)
Mammalia Thumpd2 33 16 34
  • 77 (n)
(Rattus norvegicus)
Mammalia Thumpd2 33
  • 74.67 (n)
(Monodelphis domestica)
Mammalia THUMPD2 34
  • 66 (a)
(Ornithorhynchus anatinus)
Mammalia THUMPD2 34
  • 59 (a)
(Gallus gallus)
Aves THUMPD2 33 34
  • 63.69 (n)
(Anolis carolinensis)
Reptilia THUMPD2 34
  • 48 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia thumpd2 33
  • 56.54 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.7066 33
(Danio rerio)
Actinopterygii thumpd2 33 34
  • 53.18 (n)
(Caenorhabditis elegans)
Secernentea M04B2.2 34
  • 22 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 24 (a)
Species where no ortholog for THUMPD2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for THUMPD2 Gene

Gene Tree for THUMPD2 (if available)
Gene Tree for THUMPD2 (if available)

Paralogs for THUMPD2 Gene

Paralogs for THUMPD2 Gene

genes like me logo Genes that share paralogs with THUMPD2: view

Variants for THUMPD2 Gene

Sequence variations from dbSNP and Humsavar for THUMPD2 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1000007173 -- 39,755,167(+) ACTGA(A/G)TATTA intron-variant
rs1000011613 -- 39,778,648(+) TACTG(C/T)GTGTT intron-variant
rs1000116185 -- 39,773,738(+) AAGAA(C/T)AGTAT intron-variant
rs1000126630 -- 39,741,522(+) GGTGA(A/C)TTTTT intron-variant
rs1000134730 -- 39,761,155(+) AATAA(C/T)ATATA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for THUMPD2 Gene

Variant ID Type Subtype PubMed ID
nsv833881 CNV loss 17160897
nsv833870 CNV gain 17160897
nsv2696 CNV deletion 18451855
esv3590439 CNV loss 21293372

Variation tolerance for THUMPD2 Gene

Residual Variation Intolerance Score: 26% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.32; 53.39% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for THUMPD2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for THUMPD2 Gene

Disorders for THUMPD2 Gene

Relevant External Links for THUMPD2

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for THUMPD2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for THUMPD2 Gene

Publications for THUMPD2 Gene

  1. Localization, genomic organization, and alternative transcription of a novel human SAM-dependent methyltransferase gene on chromosome 2p22-->p21. (PMID: 12063391) Zhang Y … Hart TC (Cytogenetics and cell genetics 2001) 2 3 4 22 60
  2. Genome-wide association scan for five major dimensions of personality. (PMID: 18957941) Terracciano A … Costa PT (Molecular psychiatry 2010) 3 45 60
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60

Products for THUMPD2 Gene

Sources for THUMPD2 Gene

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