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Aliases for THUMPD1 Gene

Aliases for THUMPD1 Gene

  • THUMP Domain Containing 1 2 3 5
  • TAN1 3

External Ids for THUMPD1 Gene

Previous GeneCards Identifiers for THUMPD1 Gene

  • GC16M020711
  • GC16M020652
  • GC16M019280

Summaries for THUMPD1 Gene

GeneCards Summary for THUMPD1 Gene

THUMPD1 (THUMP Domain Containing 1) is a Protein Coding gene. Among its related pathways are Gene Expression and rRNA processing. GO annotations related to this gene include poly(A) RNA binding and RNA binding.

UniProtKB/Swiss-Prot for THUMPD1 Gene

  • Functions as a tRNA-binding adapter to mediate NAT10-dependent tRNA acetylation (PubMed:25653167).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for THUMPD1 Gene

Genomics for THUMPD1 Gene

Regulatory Elements for THUMPD1 Gene

Promoters for THUMPD1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around THUMPD1 on UCSC Golden Path with GeneCards custom track

Genomic Location for THUMPD1 Gene

Chromosome:
16
Start:
20,733,664 bp from pter
End:
20,742,084 bp from pter
Size:
8,421 bases
Orientation:
Minus strand

Genomic View for THUMPD1 Gene

Genes around THUMPD1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
THUMPD1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for THUMPD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for THUMPD1 Gene

Proteins for THUMPD1 Gene

  • Protein details for THUMPD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NXG2-THUM1_HUMAN
    Recommended name:
    THUMP domain-containing protein 1
    Protein Accession:
    Q9NXG2
    Secondary Accessions:
    • Q9BWC3

    Protein attributes for THUMPD1 Gene

    Size:
    353 amino acids
    Molecular mass:
    39315 Da
    Quaternary structure:
    • Interacts with NAT10 (PubMed:25653167).

    Three dimensional structures from OCA and Proteopedia for THUMPD1 Gene

neXtProt entry for THUMPD1 Gene

Proteomics data for THUMPD1 Gene at MOPED

Post-translational modifications for THUMPD1 Gene

  • Ubiquitination at Lys 15, Lys 178, Lys 189, and Lys 254
  • Modification sites at PhosphoSitePlus

Other Protein References for THUMPD1 Gene

No data available for DME Specific Peptides for THUMPD1 Gene

Domains & Families for THUMPD1 Gene

Protein Domains for THUMPD1 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for THUMPD1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NXG2

UniProtKB/Swiss-Prot:

THUM1_HUMAN :
  • Contains 1 THUMP domain.
  • Belongs to the THUMPD1 family.
Domain:
  • Contains 1 THUMP domain.
Family:
  • Belongs to the THUMPD1 family.
genes like me logo Genes that share domains with THUMPD1: view

No data available for Gene Families for THUMPD1 Gene

Function for THUMPD1 Gene

Molecular function for THUMPD1 Gene

UniProtKB/Swiss-Prot Function:
Functions as a tRNA-binding adapter to mediate NAT10-dependent tRNA acetylation (PubMed:25653167).

Gene Ontology (GO) - Molecular Function for THUMPD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with THUMPD1: view
genes like me logo Genes that share phenotypes with THUMPD1: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for THUMPD1 Gene

Localization for THUMPD1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for THUMPD1 Gene COMPARTMENTS Subcellular localization image for THUMPD1 gene
Compartment Confidence
cytosol 3
nucleus 3
plasma membrane 2
extracellular 1
mitochondrion 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for THUMPD1 Gene

Pathways & Interactions for THUMPD1 Gene

genes like me logo Genes that share pathways with THUMPD1: view

Pathways by source for THUMPD1 Gene

Interacting Proteins for THUMPD1 Gene

Gene Ontology (GO) - Biological Process for THUMPD1 Gene

None

No data available for SIGNOR curated interactions for THUMPD1 Gene

Drugs & Compounds for THUMPD1 Gene

No Compound Related Data Available

Transcripts for THUMPD1 Gene

Unigene Clusters for THUMPD1 Gene

THUMP domain containing 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for THUMPD1 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b · 5c · 5d ^ 6
SP1: - - - -
SP2: - - -
SP3: -
SP4:
SP5:
SP6:
SP7: -

Relevant External Links for THUMPD1 Gene

GeneLoc Exon Structure for
THUMPD1
ECgene alternative splicing isoforms for
THUMPD1

Expression for THUMPD1 Gene

mRNA expression in normal human tissues for THUMPD1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for THUMPD1 Gene

This gene is overexpressed in Nasal epithelium (16.5) and Heart (7.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for THUMPD1 Gene



SOURCE GeneReport for Unigene cluster for THUMPD1 Gene Hs.700004

genes like me logo Genes that share expression patterns with THUMPD1: view

Protein tissue co-expression partners for THUMPD1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for THUMPD1 Gene

Orthologs for THUMPD1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for THUMPD1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia THUMPD1 35
  • 90.34 (n)
  • 90.06 (a)
THUMPD1 36
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia THUMPD1 35
  • 90.22 (n)
  • 89.74 (a)
THUMPD1 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Thumpd1 35
  • 85.62 (n)
  • 84.57 (a)
Thumpd1 16
Thumpd1 36
  • 84 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia THUMPD1 35
  • 99.53 (n)
  • 99.15 (a)
THUMPD1 36
  • 80 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Thumpd1 35
  • 85.23 (n)
  • 84.66 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 74 (a)
OneToMany
-- 36
  • 74 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia THUMPD1 36
  • 69 (a)
OneToOne
chicken
(Gallus gallus)
Aves THUMPD1 35
  • 72.47 (n)
  • 78.15 (a)
THUMPD1 36
  • 70 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 64 (a)
OneToMany
-- 36
  • 61 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC75804 35
thumpd1 35
  • 70.11 (n)
  • 74.33 (a)
zebrafish
(Danio rerio)
Actinopterygii thumpd1 35
  • 55.84 (n)
  • 52.23 (a)
thumpd1 36
  • 47 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007705 35
  • 49.73 (n)
  • 40.32 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG15014 35
  • 48.53 (n)
  • 38.7 (a)
CG15014 36
  • 31 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea W02G9.3 36
  • 17 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TAN1 36
  • 28 (a)
OneToOne
TAN1 38
Species with no ortholog for THUMPD1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for THUMPD1 Gene

ENSEMBL:
Gene Tree for THUMPD1 (if available)
TreeFam:
Gene Tree for THUMPD1 (if available)

Paralogs for THUMPD1 Gene

(1) SIMAP similar genes for THUMPD1 Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for THUMPD1 Gene

genes like me logo Genes that share paralogs with THUMPD1: view

No data available for Paralogs for THUMPD1 Gene

Variants for THUMPD1 Gene

Sequence variations from dbSNP and Humsavar for THUMPD1 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs11074471 - 20,737,009(+) GTATT(A/C)TCTGG reference, missense
rs3015 -- 20,735,438(+) tttgt(A/C)acatt utr-variant-3-prime
rs3016 -- 20,735,507(+) gtgtg(C/G)tataa utr-variant-3-prime
rs16417 -- 20,734,110(+) AATAC(-/AAATAA)ATATA cds-indel
rs192081 -- 20,742,815(+) tatat(A/T)tTTTT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for THUMPD1 Gene

Variant ID Type Subtype PubMed ID
nsv436835 CNV Insertion 17901297
nsv833165 CNV Loss 17160897

Variation tolerance for THUMPD1 Gene

Residual Variation Intolerance Score: 66.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.83; 67.10% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for THUMPD1 Gene

HapMap Linkage Disequilibrium report
THUMPD1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for THUMPD1 Gene

Disorders for THUMPD1 Gene

Relevant External Links for THUMPD1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
THUMPD1

No disorders were found for THUMPD1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for THUMPD1 Gene

Publications for THUMPD1 Gene

  1. Yeast Kre33 and human NAT10 are conserved 18S rRNA cytosine acetyltransferases that modify tRNAs assisted by the adaptor Tan1/THUMPD1. (PMID: 25653167) Sharma S. … Lafontaine D.L. (Nucleic Acids Res. 2015) 2 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  4. Global landscape of HIV-human protein complexes. (PMID: 22190034) JAoger S. … Krogan N.J. (Nature 2012) 3
  5. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. (PMID: 22658674) Castello A. … Hentze M.W. (Cell 2012) 3

Products for THUMPD1 Gene

Sources for THUMPD1 Gene

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