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THUMPD1 Gene

protein-coding   GIFtS: 48
GCID: GC16M020744

THUMP Domain Containing 1

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
THUMP Domain Containing 11 2
THUMP Domain-Containing Protein 12

External Ids:    HGNC: 238071   Entrez Gene: 556232   Ensembl: ENSG000000666547   UniProtKB: Q9NXG23   

Export aliases for THUMPD1 gene to outside databases

Previous GC identifers: GC16M020711 GC16M020652 GC16M019280


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for THUMPD1 Gene:
THUMPD1 (THUMP domain containing 1) is a protein-coding gene. GO annotations related to this gene include RNA binding.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the THUMPD1 gene promoter:
         PPAR-gamma1   p53   STAT3   PPAR-gamma2   C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTHUMPD1 promoter sequence
   Search Chromatin IP Primers for THUMPD1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat THUMPD1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p12.3   Ensembl cytogenetic band:  16p12.3   HGNC cytogenetic band: 16p13.11

THUMPD1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
THUMPD1 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M020744:  view genomic region     (about GC identifiers)

Start:
20,744,986 bp from pter      End:
20,753,406 bp from pter
Size:
8,421 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: THUM1_HUMAN, Q9NXG2 (See protein sequence)
Recommended Name: THUMP domain-containing protein 1  
Size: 353 amino acids; 39315 Da
1 PDB 3D structure from and Proteopedia for THUMPD1:
2DIR (3D)    
Secondary accessions: Q9BWC3

Explore the universe of human proteins at neXtProt for THUMPD1: NX_Q9NXG2

Explore proteomics data for THUMPD1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys15, Lys178, Lys189, Lys254
  • Modification sites at PhosphoSitePlus

  • See THUMPD1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_060206.2  
    ENSEMBL proteins: 
     ENSP00000370741   ENSP00000379392   ENSP00000455033   ENSP00000392282  

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    Cloud-Clone Corp. Proteins for THUMPD1

     
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    antibodies-online proteins for THUMPD1 (4 products) 

     
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    antibodies-online antibodies for THUMPD1 (15 products) 

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR004114 THUMP

    Graphical View of Domain Structure for InterPro Entry Q9NXG2

    ProtoNet protein and cluster: Q9NXG2

    1 Blocks protein domain: IPB004114 THUMP domain

    UniProtKB/Swiss-Prot: THUM1_HUMAN, Q9NXG2
    Similarity: Belongs to the THUMPD1 family
    Similarity: Contains 1 THUMP domain


    Find genes that share domains with THUMPD1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003723RNA binding ----
    GO:0044822poly(A) RNA binding IDA--
         
    Find genes that share ontologies with THUMPD1           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for THUMPD1:
     Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for THUMPD1
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for THUMPD1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for THUMPD1

    miRNA
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    miRTarBase miRNAs that target THUMPD1:
    hsa-mir-10b-5p (MIRT047484), hsa-mir-92a-3p (MIRT049811), hsa-mir-10a-5p (MIRT025618), hsa-mir-30a-5p (MIRT049931), hsa-mir-125b-5p (MIRT046075)

    Block miRNA regulation of human, mouse, rat THUMPD1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate THUMPD1 (see all 30):
    hsa-miR-26a-2* hsa-miR-3607-5p hsa-miR-562 hsa-miR-642a hsa-miR-15a hsa-miR-503 hsa-miR-431 hsa-miR-570
    SwitchGear 3'UTR luciferase reporter plasmidTHUMPD1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat THUMPD1

    Gene Editing
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    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat THUMPD1

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for THUMPD1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    plasma membrane2
    cytosol1
    extracellular1
    mitochondrion1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for THUMPD1
    Interactions:

        Search GeneGlobe Interaction Network for THUMPD1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for THUMPD1 (ENSP000003707414) via UniProtKB, MINT, STRING, and/or I2D (see all 72)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PSMA3ENSP000002164554STRING: ENSP00000216455
    PSMA5ENSP000002713084STRING: ENSP00000271308
    PSMA6ENSP000002614794STRING: ENSP00000261479
    MAD2L1ENSP000002965094STRING: ENSP00000296509
    PSMA2ENSP000002233214STRING: ENSP00000223321
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for THUMPD1 (THUM1)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for THUMPD1 gene: 
    NM_017736.3  

    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000381337(uc010vaz.2 uc002dhp.3 uc002dho.3) ENST00000396083
    ENST00000570231 ENST00000565248 ENST00000569768 ENST00000431224
    miRNA
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    Block miRNA regulation of human, mouse, rat THUMPD1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate THUMPD1 (see all 30):
    hsa-miR-26a-2* hsa-miR-3607-5p hsa-miR-562 hsa-miR-642a hsa-miR-15a hsa-miR-503 hsa-miR-431 hsa-miR-570
    SwitchGear 3'UTR luciferase reporter plasmidTHUMPD1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for THUMPD1
    Predesigned siRNA for gene silencing in human, mouse, rat THUMPD1
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    OriGene clones in human, mouse for THUMPD1 (see all 6)
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    GenScript: all cDNA clones in your preferred vector: THUMPD1 (NM_017736)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat THUMPD1
    Primer
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    OriGene qPCR primer pairs and template standards for THUMPD1
    OriGene qSTAR qPCR primer pairs in human, mouse for THUMPD1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat THUMPD1
      QuantiTect SYBR Green Assays in human, mouse, rat THUMPD1
      QuantiFast Probe-based Assays in human, mouse, rat THUMPD1

    Selected AceView cDNA sequences (see all 224):

    R76688 BM765897 BQ893363 AL134903 BM673561 AA251488 AW593186 BE350065 
    AA831172 BX459494 AI192416 Z39608 AA252018 AI674206 CA449642 BF115606 
    BP377292 AA115419 AA722928 NM_017736 BF222009 BX116504 BM787206 BC000448 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for THUMPD1 (see all 7)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b · 5c · 5d ^ 6
    SP1:              -                 -     -     -                                             
    SP2:              -                 -     -                                                   
    SP3:              -                                                                           
    SP4:                                                                                          
    SP5:                                                                                          


    ECgene alternative splicing isoforms for THUMPD1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    THUMPD1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATTCTCTGAG
    THUMPD1 Expression
    About this image


    THUMPD1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Epiblast (Early Embryonic Tissues)
             Epiblast Stem Cell line 7
    THUMPD1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    THUMPD1 Protein Expression
        Custom PCR Arrays for THUMPD1
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for THUMPD1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for THUMPD1 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Thumpd11 , 5 THUMP domain containing 11, 5 85.62(n)1
    84.57(a)1
      7 (64.13 cM)5
    2338021  NM_145585.21  NP_663560.11 
     1197150965 
    chicken
    (Gallus gallus)
    Aves THUMPD11 THUMP domain containing 1 72.47(n)
    78.15(a)
      426998  XM_424600.3  XP_424600.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    64(a)
    61(a)
    many → 1
    many → 1
    AAWZ02041611(21-5275)
    GL343402.1(765062-773631)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia MGC758042 hypothetical protein MGC75804 77.85(n)    BC061320.1 
    zebrafish
    (Danio rerio)
    Actinopterygii thumpd11 THUMP domain containing 1 55.84(n)
    52.23(a)
      402955  NM_205657.1  NP_991220.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG150141 CG15014 48.53(n)
    38.7(a)
      38533  NM_139635.2  NP_647892.1 
    worm
    (Caenorhabditis elegans)
    Secernentea W02G9.36
    Protein W02G9.3 (W02G9.3) mRNA, complete cds
    17(a)
    1 ↔ 1
    V(2671464-2673973) WBGene00020953
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes TAN1(YGL232W)4 Putative tRNA acetyltransferase, RNA-binding protein more   --   7(62075-63002) 852619  NP_011282.1 


    ENSEMBL Gene Tree for THUMPD1 (if available)
    TreeFam Gene Tree for THUMPD1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for THUMPD1 gene
    1 SIMAP similar gene for THUMPD1 using alignment to 4 protein entries:     THUM1_HUMAN (see all proteins):
    44M2.1

    Find genes that share paralogs with THUMPD1           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for THUMPD1
    PGOHUM00000239059


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for THUMPD1 (see all 271)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1819573801,2
    --20744524(+) TGATGA/GTTTCT 1 -- ds50010--------
    rs1155988951,2
    F--20744649(+) TTCAAG/AACAAT 1 -- ds50011Minor allele frequency- A:0.03WA 118
    rs2003375281,2
    C--20744655(+) ACAAT-/TTCTTCTA 1 -- ds50010--------
    rs99368801,2
    C,H--20744985(+) CACCAA/TTTTTT 1 -- ds50014Minor allele frequency- T:0.00NS EA 416
    rs759302101,2
    C,F--20745186(+) AACCAT/CAAGAC 1 -- ut311Minor allele frequency- C:0.13WA 118
    rs10589051,2
    C,F,A,H--20745255(-) GTGCTT/GTTTAT 1 -- ut3114Minor allele frequency- G:0.38MN NS EA NA WA 974
    rs10589041,2
    C,F,A,H--20745277(-) TGACGG/AGATTC 1 -- ut31 ese327Minor allele frequency- A:0.50MN NA NS EA WA CSA 2562
    rs80588151,2
    C,F--20745361(+) TTCAGG/CTTACA 1 -- ut311Minor allele frequency- C:0.03WA 118
    rs1846509601,2
    --20745370(+) CAACCA/GAACAC 1 -- ut310--------
    rs10589021,2
    C,F,A,H--20745451(-) TTTAAA/GTTGTC 1 -- ut3120Minor allele frequency- G:0.28MN NS EA NA WA 2522

    HapMap Linkage Disequilibrium report for THUMPD1 (20744986 - 20753406 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for THUMPD1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv436835CNV Insertion17901297
    nsv833165CNV Loss17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing THUMPD1
    DNA2.0 Custom Variant and Variant Library Synthesis for THUMPD1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for THUMPD1 gene, integrated from 10 sources (see all 20):
    (articles sorted by number of sources associating them with THUMPD1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    5. Global landscape of HIV-human protein complexes. (PubMed id 22190034)1 JAoger S....Krogan N.J. (Nature 2012)
    6. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    7. A high-throughput approach for measuring temporal changes in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (Nat. Methods 2012)
    8. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PubMed id 22814378)2 Van Damme P....Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012)
    9. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    10. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 55623 HGNC: 23807 AceView: THUMPD1 Ensembl:ENSG00000066654 euGenes: HUgn55623
    ECgene: THUMPD1 H-InvDB: THUMPD1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for THUMPD1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for THUMPD1 gene:
    Search GeneIP for patents involving THUMPD1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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