THUMPD1 Gene
protein-coding GIFtS: 45
GCID: GC16M020744
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THUMP domain containing 1
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Aliases
for THUMPD1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| THUMP Domain Containing 11 2 | | FLJ202741 | | THUMP Domain-Containing Protein 12 |
Export aliases for THUMPD1 gene to outside databasesPrevious GC identifers: GC16M020711 GC16M020652 GC16M019280 |
Summaries
for THUMPD1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for THUMPD1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000016.9 NC_018927.1 NT_010393.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the THUMPD1 gene promoter:
PPAR-gamma1 p53 STAT3 PPAR-gamma2 C/EBPalpha
Other transcription factors
Search SABiosciences Chromatin IP Primers for THUMPD1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat THUMPD1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 16p12.3 Ensembl cytogenetic band: 16p12.3 HGNC cytogenetic band: 16p13.11THUMPD1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 16 GeneLoc Exon Structure GeneLoc location for GC16M020744: view genomic region
(about GC identifiers)
Start:
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20,744,986 bp from pter |
End:
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20,753,406 bp from pter |
Size:
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8,421 bases |
Orientation:
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minus strand |
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Proteins
for THUMPD1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: THUM1_HUMAN, Q9NXG2 (See
protein sequence)Recommended Name: THUMP domain-containing protein 1 Size: 353 amino acids; 39315 Da
1 PDB 3D structure from  and Proteopedia  for THUMPD1:2DIR (3D)
Secondary accessions: Q9BWC3Explore the universe of human proteins at neXtProt for THUMPD1: NX_Q9NXG2
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9NXG2
THUMPD1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_060206.2
ENSEMBL proteins: ENSP00000370741 ENSP00000379392 ENSP00000455033 ENSP00000392282
Human Recombinant Protein Products:
THUMPD1 Antibody Products:
Assay Products for THUMPD1: |
Protein
Domains /
Families
for THUMPD1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
THUMPD1 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q9NXG2ProtoNet protein and cluster: Q9NXG2 1 Blocks protein family: IPB004114 THUMP domain
UniProtKB/Swiss-Prot: THUM1_HUMAN, Q9NXG2Similarity: Belongs to the THUMPD1 familySimilarity: Contains 1 THUMP domain |
Function
for THUMPD1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for THUMPD1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for THUMPD1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: THUMPD1 (NM_017736) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for THUMPD1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat THUMPD1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for THUMPD1 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003723 | RNA binding |
IEA | -- |
THUMPD1 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for THUMPD1:
|
Pathways & Interactions
for THUMPD1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for THUMPD1
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
1 Interacting protein for THUMPD1 (ENSP000003707414) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for THUMPD1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for THUMPD1
Search CenterWatch for drugs/clinical trials and news about THUMPD1 / THUM1
|
Transcripts
for THUMPD1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for THUMPD1 gene: NM_017736.3 Unigene Cluster for THUMPD1: THUMP domain containing 1 Hs.700004 [show with all ESTs]Unigene Representative Sequence: NM_0177366 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000381337(uc010vaz.2 uc002dhp.3 uc002dho.3) ENST00000396083
ENST00000570231 ENST00000565248 ENST00000569768 ENST00000431224
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for THUMPD1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for THUMPD1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: THUMPD1 (NM_017736) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for THUMPD1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat THUMPD1 |
Additional cDNA sequence: AK000281.1 AK294328.1 BC000448.2 BX640898.1 6 DOTS entries: DT.40260291 DT.417349 DT.120722673 DT.91837480 DT.91929761 DT.120722701 24/224 AceView cDNA sequences (see all 224): BC000448 R76688 AI867958 NM_017736 BQ893363 AA722928 AA831172 BM673561 BE350065 AL134903 AI377356 AA252018 BX459494 AI674206 CA449642 AW593186 AA326624 AA662495 BF222009 BX116504 AA478697 AI865166 BM787206 AI912243
GeneLoc Exon Structure
5/7 Alternative Splicing Database (ASD) splice patterns (SP) for THUMPD1 (see all 7) About this scheme
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | · | 2c | · | 2d | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5a | · | 5b | · | 5c | · | 5d | ^ | 6 |
|---|
|
| SP1: | | | | | - | | | | | | - | | - | | - | | | | | | | | | | | | | | | | |
| SP2: | | | | | - | | | | | | - | | - | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for THUMPD1
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Expression
for THUMPD1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| THUMPD1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ATTCTCTGAG
About this image
See THUMPD1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for THUMPD1
SOURCE GeneReport for Unigene cluster: Hs.700004
SABiosciences Custom PCR Arrays for THUMPD1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for THUMPD1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat THUMPD1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat THUMPD1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat THUMPD1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for THUMPD1 |
Orthologs
for THUMPD1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for THUMPD1 gene from 10/27 species (see all 27) About this table
ENSEMBL Gene Tree for THUMPD1 (if available)
TreeFam Gene Tree for THUMPD1 (if available) |
Paralogs
for THUMPD1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for THUMPD1 gene
1 SIMAP similar gene for THUMPD1 using alignment to 4 protein entries: THUM1_HUMAN (see all proteins):44M2.1
THUMPD1 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for THUMPD1
PGOHUM00000239059
|
Genomic Variants
for THUMPD1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 16 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for THUMPD1 (20744986 - 20753406 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for THUMPD1: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing THUMPD1 |
|
Disorders
/ Diseases
for THUMPD1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for THUMPD1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for THUMPD1 gene, integrated from 9 sources (see all 17):
(articles sorted by number of sources associating them with THUMPD1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Global landscape of HIV-human protein complexes. (PubMed id 22190034)1 Jager S....Krogan N.J. (2012)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
- A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
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External Searches for THUMPD1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing THUMPD1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing THUMPD1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing THUMPD1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for THUMPD1 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for THUMPD1 gene:
Search GeneIP for patents involving THUMPD1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for THUMPD1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for THUMPD1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for THUMPD1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for THUMPD1 | | | OriGene Protein Over-expression Lysate for THUMPD1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for THUMPD1 | | OriGene 3'-UTR Clone for THUMPD1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for THUMPD1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for THUMPD1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for THUMPD1 | | OriGene Custom Protein Services for THUMPD1 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat THUMPD1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing THUMPD1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat THUMPD1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat THUMPD1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat THUMPD1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat THUMPD1 |
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 | | | THUMPD1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for THUMPD1 |
|  |  |  | | | | Search ThermoFisher Antibodies for THUMPD1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat THUMPD1 |
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