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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

THTPA Gene

protein-coding   GIFtS: 52
GCID: GC14P024025

thiamine triphosphatase
 Explore 5 diseases affiliated with
THTPA via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for THTPA    

Aliases
for THTPA gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Thiamine Triphosphatase1 2
THTPASE1 2
EC 3.6.1.283 8
THTP2
Thiamine-Triphosphatase1
ThTPase3

External Ids:    HGNC: 189871   Entrez Gene: 791782   Ensembl: ENSG000002594317   OMIM: 6116125   UniProtKB: Q9BU023   
ORGUL members:         
NONCODE:n406446    

Export aliases for THTPA gene to outside databases

Previous GC identifers: GC14P021397 GC14P017812 GC14P022015 GC14P023095 GC14P004141


Summaries
for THTPA gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for THTPA:
This gene encodes an enzyme which catalyzes the biosynthesis of thiamine disphophate (vitamin B1) by hydrolysis of
thiamine triphosphate. Alternative splicing results in multiple transcript variants. (provided by RefSeq, Dec 2011)

UniProtKB/Swiss-Prot: THTPA_HUMAN, Q9BU02
Function: Hydrolase highly specific for thiamine triphosphate (ThTP)




Genomic Views
for THTPA gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000014.8  NC_018925.1  NT_026437.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the THTPA gene promoter:
         Tal-1beta   AP-2gamma   GATA-1   E47   POU2F1   COMP1   AP-2beta   AP-2alpha   AP-2alphaA   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: THTPA promoter sequence
   Search SABiosciences Chromatin IP Primers for THTPA

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat THTPA


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q11.2   Ensembl cytogenetic band:  14q11.2   HGNC cytogenetic band: 14q11.2

THTPA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
THTPA gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14P024025:  view genomic region     (about GC identifiers)

Start:
 24,025,198 bp from pter      End:
 24,029,480 bp from pter
Size:
 4,283 bases      Orientation:
 plus strand

Proteins
for THTPA gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: THTPA_HUMAN, Q9BU02 (See protein sequence)
Recommended Name: Thiamine-triphosphatase  
Size: 230 amino acids; 25566 Da
Subunit: Monomer (By similarity)
Subcellular location: Cytoplasm
2 PDB 3D structures from and Proteopedia for THTPA:
3BHD (3D)        3TVL (3D)    
Secondary accessions: D3DS50

Explore the universe of human proteins at neXtProt for THTPA: NX_Q9BU02

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9BU02

    • 3 DME Specific Peptides for THTPA (Q9BU02)
     VYLQRFRP  TEERLQELG  DFGYAVGEVEA 

    THTPA Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (6 alternative transcripts): 
    NP_001119811.1  NP_001242991.1  NP_001243250.1  NP_001243251.1  NP_001243252.1  NP_077304.1  

    ENSEMBL proteins: 
     ENSP00000384580   ENSP00000288014   ENSP00000452281   ENSP00000451835   ENSP00000452465  
     ENSP00000450459   ENSP00000452164  
    Reactome Protein details: Q9BU02
    Human Recombinant Protein Products: 
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    OriGene Purified Proteins (see all 2): THTPA
    OriGene Protein Over-expression Lysate (see all 2): THTPA
    OriGene Custom Protein Services for THTPA 
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    Novus Biologicals THTPA Proteins
    Novus Biologicals THTPA Lysates
    Browse Sino Biological Recombinant Proteins
    ProSpec Recombinant Protein for THTPA
    Uscn Proteins for THTPA

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005829cytosol TAS--


    THTPA for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for THTPA

    Protein Domains /
    Families
    for THTPA gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    THTPA for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR012177 ThTPase
     IPR023577 CYTH-like_domain

    Graphical View of Domain Structure for InterPro Entry Q9BU02

    ProtoNet protein and cluster: Q9BU02

    1 Blocks protein family: IPB008172 Adenylate cyclase

    UniProtKB/Swiss-Prot: THTPA_HUMAN, Q9BU02
    Similarity: Belongs to the ThTPase family


    Function
    for THTPA gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: THTPA_HUMAN, Q9BU02
    Function: Hydrolase highly specific for thiamine triphosphate (ThTP)
    Catalytic activity: Thiamine triphosphate + H(2)O = thiamine diphosphate + phosphate

    Enzyme Number (IUBMB): EC 3.6.1.281 2

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat THTPA
    8/30 QIAGEN miScript miRNA Assays for microRNAs that regulate THTPA (see all 30):
    hsa-miR-485-5p hsa-miR-1321 hsa-miR-605 hsa-miR-218 hsa-miR-606 hsa-miR-650 hsa-miR-1255a hsa-miR-3180-3p
    SwitchGear 3'UTR luciferase reporter plasmid: THTPA 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for THTPA (see all 7)
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    Gene Editing
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    Clone
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for THTPA
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat THTPA 

    Cell Line
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    Search LifeMap BioReagents cell lines for THTPA

    In Situ Assay
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    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016787hydrolase activity TAS11827967
    GO:0046872metal ion binding IEA--
    GO:0050333thiamin-triphosphatase activity TAS--


    THTPA for ontologies           About GeneDecksing



    Pathways & Interactions
    for THTPA gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Vitamin B1 (thiamin) metabolism
    		Vitamin B1 (thiamin) metabolism1.00
    		Thiamine metabolism0.33
    2Metabolism
    		Metabolism1.00
    		Metabolic pathways0.38
    3Vitamin B5 (pantothenate) metabolism
    		Metabolism of vitamins and cofactors0.21
    		Metabolism of water-soluble vitamins and cofactors0.21

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    4        Reactome Pathways for THTPA
        Vitamin B1 (thiamin) metabolism
    Metabolism
    Metabolism of vitamins and cofactors
    Metabolism of water-soluble vitamins and cofactors


    2         Kegg Pathways  (Kegg details for THTPA):
        Thiamine metabolism
    Metabolic pathways


    THTPA for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for THTPA

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    5/6 Interacting proteins for THTPA (Q9BU023 ENSP000002880144) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CAMKK2Q96RR43I2D: score=1 
    CLN3Q132863I2D: score=1 
    WIPI2Q9Y4P83I2D: score=1 
    TPK1ENSP000003531654STRING: ENSP00000353165
    NTPCRENSP000003555874STRING: ENSP00000355587
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006091generation of precursor metabolites and energy NAS11827967
    GO:0006766vitamin metabolic process TAS--
    GO:0006767water-soluble vitamin metabolic process TAS--
    GO:0006772thiamine metabolic process TAS11827967
    GO:0006796phosphate-containing compound metabolic process ----


    THTPA for ontologies           About GeneDecksing



    Drugs & Compounds
    for THTPA gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    THTPA for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for THTPA

    5 HMDB Compounds for THTPA    About this table
    CompoundSynonyms CAS #PubMed Ids
    PhosphateNFB Orthophosphate (see all 13)14265-44-2--
    ThiamineAneurin (see all 44)59-43-8--
    Thiamine pyrophosphateTPP (see all 11)154-87-0--
    Thiamine triphosphateThiamin triphosphate (see all 4)3475-65-8--
    WaterDihydrogen oxide (see all 2)7732-18-5--
    3 Novoseek chemical compound relationships for THTPA gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    thiamine triphosphate 98.3 9 11827967 (2), 14769791 (1), 15120844 (1), 15109578 (1) (see all 6)
    thiamine 84.5 21 12456267 (2), 15120844 (2), 11827967 (2), 15109578 (2) (see all 9)
    atp 12.7 1 15109578 (1)

    Search CenterWatch for drugs/clinical trials and news about THTPA 

    Transcripts
    for THTPA gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for THTPA gene (6 alternative transcripts): 
    NM_001126339.2  NM_001256062.1  NM_001256321.1  NM_001256322.1  NM_001256323.1  NM_024328.4  

    Unigene Cluster for THTPA:

    Thiamine triphosphatase
    Hs.655179  [show with all ESTs]
    Unigene Representative Sequence: AK094211
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000404535(uc001wkh.4 uc010akr.3) ENST00000288014(uc001wkg.4)
    ENST00000557630 ENST00000556015 ENST00000554970 ENST00000554789 ENST00000556545


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    8/30 QIAGEN miScript miRNA Assays for microRNAs that regulate THTPA (see all 30):
    hsa-miR-485-5p hsa-miR-1321 hsa-miR-605 hsa-miR-218 hsa-miR-606 hsa-miR-650 hsa-miR-1255a hsa-miR-3180-3p
    SwitchGear 3'UTR luciferase reporter plasmid: THTPA 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for THTPA (see all 7)
    OriGene shRNA RFP: THTPA
    OriGene siRNA: THTPA
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat THTPA
    Clone
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    Primer
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    Additional cDNA sequence: 

    AF432862.1 AK057691.1 AK094211.1 AK098604.1 BC002984.1 BC131549.1 BX161435.1 NR_023314.3 
    NR_046051.1 NR_046052.1 

    9 DOTS entries:

    DT.456303  DT.92424855  DT.100777724  DT.95280352  DT.120750802  DT.121639184  DT.100882738  DT.100777722 
    DT.100882753 

    24/162 AceView cDNA sequences (see all 162):

    CR624479 BE797506 BM673249 BQ025958 AA418844 BF882085 CR626464 AI554754 
    BX326107 AK094211 AA142884 AI272073 AW118859 CB054398 BI913387 BF725327 
    AA534941 AI753989 AK098604 CR615822 BF939968 BI522644 BM451289 BC002984 

    GeneLoc Exon Structure


    Expression
    for THTPA gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    THTPA expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    THTPA expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Neural TubeTelencephalonNeural Tube
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See THTPA Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for THTPA

    SOURCE GeneReport for Unigene cluster: Hs.655179

    UniProtKB/Swiss-Prot: THTPA_HUMAN, Q9BU02
    Tissue specificity: Widely expressed but at a low level

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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for THTPA

    Orthologs
    for THTPA gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for THTPA gene from 4/11 species (see all 11)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Thtpa1 , 5 thiamine triphosphatase1, 5 82.18(n)1
    74.65(a)1    		   14 (28.07 cM)5
    1056631  NM_153083.51  NP_694723.11 
     550948355 
    lizard
    (Anolis carolinensis)    		 Reptilia THTPA6
    		 --
    		 45(a)
    		 1 ↔ 1
    		 GL343877.1(139327-141038)
    tropical clawed frog
    (Xenopus tropicalis)    		 Amphibia 1420067652   -- 75.9(n)    142006765 
    zebrafish
    (Danio rerio)    		 Actinopterygii thtpa1 thiamine triphosphatase 48.68(n)
    38.61(a)    		   100048920  XM_001923019.2  XP_001923054.2 


    ENSEMBL Gene Tree for THTPA (if available)
    TreeFam Gene Tree for THTPA (if available) 

    Paralogs
    for THTPA gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    		  --

    Genomic Variants
    for THTPA gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/700 NCBI SNPs in THTPA are shown (see all 700)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 14 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs795817971,2
    		F,--23979019(+) TATCAC/GCTGGA 1 -- us2k11Minor allele frequency- G:0.02WA 118
    rs781370461,2
    		--23979028(+) GAAATA/TTGGCA 1 -- us2k10--------
    rs1423507071,2
    		C,--23979028(+) AAATA-/TGAATGT
    AGATCTCTT    TGGCA     		1 -- us2k10--------
    rs12683801,2
    		C,F,--23979041(+) TCAAAT/ATTGTA 1 -- us2k16Minor allele frequency- A:0.20NA WA EA 366
    rs1997716191,2
    		--23979120(+) TTGTT-/GGGGGG 1 -- us2k10--------
    rs1181162321,2
    		F,--23979123(+) GTTGGG/TGGGGG 1 -- us2k11Minor allele frequency- T:0.04EA 120
    rs1416985331,2
    		--23979150(+) TGGGTA/GTGACG 1 -- us2k10--------
    rs1847285181,2
    		--23979241(+) TTACCA/GTTGTT 1 -- us2k10--------
    rs172563571,2
    		C,F,H,--23979242(+) TACCAT/CTGTTC 1 -- us2k119Minor allele frequency- C:0.11NA NS EA 2202
    rs1145665361,2
    		--23979244(+) CCATTG/ATTCTT 1 -- us2k11Minor allele frequency- A:0.01WA 118

    HapMap Linkage Disequilibrium report for THTPA (24025198 - 24029480 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for THTPA: --

    SABiosciences Cancer Mutation PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing THTPA
    DNA2.0 Custom Variant and Variant Library Synthesis for THTPA

    Disorders / Diseases
    for THTPA gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    THTPA for disorders           About GeneDecksing

    OMIM gene information: 611612    OMIM disorders: --

    5 diseases for THTPA:    About MalaCards
    wernicke-korsakoff syndrome    leigh disease    parkinson's disease    alzheimer's disease
    neuronitis

    2 diseases from the University of Copenhagen DISEASES database for THTPA:
    Wernicke-Korsakoff syndrome     Leigh disease

    1 Novoseek disease relationship for THTPA gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    thiamine deficiency 71.9 2 8619543 (1), 15120844 (1)


    Export disorders for THTPA gene to outside databases

    Publications
    for THTPA gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for THTPA gene, integrated from 9 sources (see all 27):
    (articles sorted by number of sources associating them with THTPA)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular characterization of a specific thiamine triphosphatase widely expressed in mammalian tissues. (PubMed id 11827967)1, 2, 3, 9 Lakaye B.... Bettendorff L. (2002)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. The DNA sequence and analysis of human chromosome 14. (PubMed id 12508121)1, 2 Heilig R.... Weissenbach J. (2003)
    5. Human recombinant thiamine triphosphatase: purification, secondary structure and catalytic properties. (PubMed id 15109578)1, 9 Lakaye B....Bettendorff L. (2004)
    6. [The rate of molecular evolution of mammalian soluble thiamine triphosphatase] (PubMed id 20387656)1, 9 (2009)
    7. Proteome-wide identification of ubiquitylation sites b y conjugation of engineered lysine-less ubiquitin. (PubMed id 22053931)1 Oshikawa K....Nakayama K.I. (2012)
    8. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    9. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    10. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)

    External Searches for THTPA gene

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
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    Genome Databases showing THTPA gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 79178 HGNC: 18987 AceView: THTPA Ensembl:ENSG00000259431 euGenes: HUgn79178
    ECgene: THTPA Kegg: 79178 H-InvDB: THTPA

    Other Databases showing THTPA gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing THTPA gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for THTPA Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for THTPA gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for THTPA gene:
    Search GeneIP for patents involving THTPA

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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