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Aliases for THTPA Gene

Aliases for THTPA Gene

  • Thiamine Triphosphatase 2 3 5
  • EC 4 63
  • THTPASE 3 4
  • THTP 3

External Ids for THTPA Gene

Previous GeneCards Identifiers for THTPA Gene

  • GC14P021397
  • GC14P017812
  • GC14P022015
  • GC14P023095
  • GC14P024025
  • GC14P004141
  • GC14P023548
  • GC14P023556

Summaries for THTPA Gene

Entrez Gene Summary for THTPA Gene

  • This gene encodes an enzyme which catalyzes the biosynthesis of thiamine disphophate (vitamin B1) by hydrolysis of thiamine triphosphate. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2011]

GeneCards Summary for THTPA Gene

THTPA (Thiamine Triphosphatase) is a Protein Coding gene. Among its related pathways are Metabolism of water-soluble vitamins and cofactors and Metabolism. GO annotations related to this gene include hydrolase activity and thiamin-triphosphatase activity.

UniProtKB/Swiss-Prot for THTPA Gene

  • Hydrolase highly specific for thiamine triphosphate (ThTP).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for THTPA Gene

Genomics for THTPA Gene

Regulatory Elements for THTPA Gene

Enhancers for THTPA Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around THTPA on UCSC Golden Path with GeneCards custom track

Promoters for THTPA Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around THTPA on UCSC Golden Path with GeneCards custom track

Genomic Location for THTPA Gene

23,511,760 bp from pter
23,560,271 bp from pter
48,512 bases
Plus strand

Genomic View for THTPA Gene

Genes around THTPA on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
THTPA Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for THTPA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for THTPA Gene

Proteins for THTPA Gene

  • Protein details for THTPA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • D3DS50
    • G3V4J3

    Protein attributes for THTPA Gene

    230 amino acids
    Molecular mass:
    25566 Da
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Monomer.

    Three dimensional structures from OCA and Proteopedia for THTPA Gene

    Alternative splice isoforms for THTPA Gene


neXtProt entry for THTPA Gene

Proteomics data for THTPA Gene at MOPED

Selected DME Specific Peptides for THTPA Gene

Post-translational modifications for THTPA Gene

  • Ubiquitination at Lys 11 and Lys 193
  • Modification sites at PhosphoSitePlus

Domains & Families for THTPA Gene

Protein Domains for THTPA Gene


Suggested Antigen Peptide Sequences for THTPA Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 CYTH domain.
  • Belongs to the ThTPase family.
  • Contains 1 CYTH domain.
  • Belongs to the ThTPase family.
genes like me logo Genes that share domains with THTPA: view

No data available for Gene Families for THTPA Gene

Function for THTPA Gene

Molecular function for THTPA Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=8 uM for thiamine triphosphate {ECO:0000269 PubMed:23707715}; Vmax=59 umol/min/mg enzyme {ECO:0000269 PubMed:23707715};
UniProtKB/Swiss-Prot CatalyticActivity:
Thiamine triphosphate + H(2)O = thiamine diphosphate + phosphate.
UniProtKB/Swiss-Prot Function:
Hydrolase highly specific for thiamine triphosphate (ThTP).

Enzyme Numbers (IUBMB) for THTPA Gene

Gene Ontology (GO) - Molecular Function for THTPA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0050333 thiamin-triphosphatase activity TAS --
genes like me logo Genes that share ontologies with THTPA: view
genes like me logo Genes that share phenotypes with THTPA: view

Animal Model Products

miRNA for THTPA Gene

miRTarBase miRNAs that target THTPA

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for THTPA Gene

Localization for THTPA Gene

Subcellular locations from UniProtKB/Swiss-Prot for THTPA Gene


Subcellular locations from

Jensen Localization Image for THTPA Gene COMPARTMENTS Subcellular localization image for THTPA gene
Compartment Confidence
cytosol 5
mitochondrion 1

No data available for Gene Ontology (GO) - Cellular Components for THTPA Gene

Pathways & Interactions for THTPA Gene

genes like me logo Genes that share pathways with THTPA: view

Interacting Proteins for THTPA Gene

Gene Ontology (GO) - Biological Process for THTPA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006766 vitamin metabolic process TAS --
GO:0006772 thiamine metabolic process TAS 11827967
GO:0042357 thiamine diphosphate metabolic process ISS --
GO:0044281 small molecule metabolic process TAS --
genes like me logo Genes that share ontologies with THTPA: view

No data available for SIGNOR curated interactions for THTPA Gene

Drugs & Compounds for THTPA Gene

(3) Drugs for THTPA Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Thiamine Approved Nutra 94,94
thiamin diphosphate Experimental Pharma 0

(4) Additional Compounds for THTPA Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
thiamine triphosphate
  • Thiamin triphosphate
  • Thiamine triphosphate
  • ThTP
  • NFB Orthophosphate
  • O-Phosphoric acid
  • Ortho-phosphate
  • Orthophosphate (PO43-)
  • Orthophosphate(3-)
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
  • Dihydrogen oxide
  • Steam
genes like me logo Genes that share compounds with THTPA: view

Transcripts for THTPA Gene

Unigene Clusters for THTPA Gene

Thiamine triphosphatase:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for THTPA Gene

No ASD Table

Relevant External Links for THTPA Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for THTPA Gene

mRNA expression in normal human tissues for THTPA Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for THTPA Gene

This gene is overexpressed in Ovary (9.1) and Seminal vesicle (7.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for THTPA Gene

SOURCE GeneReport for Unigene cluster for THTPA Gene Hs.655179

mRNA Expression by UniProt/SwissProt for THTPA Gene

Tissue specificity: Widely expressed but at a low level.
genes like me logo Genes that share expression patterns with THTPA: view

Protein tissue co-expression partners for THTPA Gene

Primer Products

No data available for mRNA differential expression in normal tissues for THTPA Gene

Orthologs for THTPA Gene

This gene was present in the common ancestor of chordates.

Orthologs for THTPA Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia THTPA 35
  • 86.91 (n)
  • 84.47 (a)
  • 84 (a)
(Canis familiaris)
Mammalia THTPA 35
  • 86.67 (n)
  • 79.13 (a)
  • 79 (a)
(Mus musculus)
Mammalia Thtpa 35
  • 82.18 (n)
  • 74.65 (a)
Thtpa 16
Thtpa 36
  • 72 (a)
(Pan troglodytes)
Mammalia THTPA 35
  • 99.13 (n)
  • 98.26 (a)
  • 98 (a)
(Rattus norvegicus)
Mammalia Thtpa 35
  • 83.1 (n)
  • 73.73 (a)
(Monodelphis domestica)
Mammalia THTPA 36
  • 65 (a)
(Anolis carolinensis)
Reptilia THTPA 36
  • 44 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia thtpa 35
  • 53.27 (n)
  • 44.61 (a)
(Danio rerio)
Actinopterygii thtpa 35
  • 48.82 (n)
  • 39.9 (a)
thtpa 36
  • 32 (a)
Species with no ortholog for THTPA:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for THTPA Gene

Gene Tree for THTPA (if available)
Gene Tree for THTPA (if available)

Paralogs for THTPA Gene

No data available for Paralogs for THTPA Gene

Variants for THTPA Gene

Sequence variations from dbSNP and Humsavar for THTPA Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
VAR_062152 -
rs222670 -- 23,515,634(+) CCCAG(C/T)GACTG intron-variant
rs222671 -- 23,516,764(+) GCAGA(A/G)GATGC intron-variant
rs222672 -- 23,516,984(+) ACCCC(A/G)GGTGC intron-variant
rs222673 -- 23,518,055(+) TTGGG(A/G)TATGT intron-variant

Variation tolerance for THTPA Gene

Residual Variation Intolerance Score: 23.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.38; 76.96% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for THTPA Gene

Disorders for THTPA Gene

Relevant External Links for THTPA

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for THTPA Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for THTPA Gene

Publications for THTPA Gene

  1. Molecular characterization of a specific thiamine triphosphatase widely expressed in mammalian tissues. (PMID: 11827967) Lakaye B. … Bettendorff L. (J. Biol. Chem. 2002) 2 3 4 23 67
  2. [The rate of molecular evolution of mammalian soluble thiamine triphosphatase]. (PMID: 20387656) Makarchikov A.F. (Ukr. Biokhim. Zh. 2009) 3 23
  3. Human recombinant thiamine triphosphatase: purification, secondary structure and catalytic properties. (PMID: 15109578) Lakaye B. … Bettendorff L. (Int. J. Biochem. Cell Biol. 2004) 3 23
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. A census of human soluble protein complexes. (PMID: 22939629) Havugimana P.C. … Emili A. (Cell 2012) 3

Products for THTPA Gene

Sources for THTPA Gene