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Aliases for THTPA Gene

Aliases for THTPA Gene

  • Thiamine Triphosphatase 2 3
  • EC 4 63
  • THTPASE 3 4
  • Thiamine-Triphosphatase 3
  • THTP 3

External Ids for THTPA Gene

Previous GeneCards Identifiers for THTPA Gene

  • GC14P021397
  • GC14P017812
  • GC14P022015
  • GC14P023095
  • GC14P024025
  • GC14P004141

Summaries for THTPA Gene

Entrez Gene Summary for THTPA Gene

  • This gene encodes an enzyme which catalyzes the biosynthesis of thiamine disphophate (vitamin B1) by hydrolysis of thiamine triphosphate. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2011]

GeneCards Summary for THTPA Gene

THTPA (Thiamine Triphosphatase) is a Protein Coding gene. Diseases associated with THTPA include wernicke-korsakoff syndrome. Among its related pathways are Disease and Metabolism. GO annotations related to this gene include hydrolase activity and thiamin-triphosphatase activity.

UniProtKB/Swiss-Prot for THTPA Gene

  • Hydrolase highly specific for thiamine triphosphate (ThTP).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for THTPA Gene

Genomics for THTPA Gene

Regulatory Elements for THTPA Gene

Genomic Location for THTPA Gene

23,511,760 bp from pter
23,560,271 bp from pter
48,512 bases
Plus strand

Genomic View for THTPA Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for THTPA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for THTPA Gene

Proteins for THTPA Gene

  • Protein details for THTPA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • D3DS50
    • G3V4J3

    Protein attributes for THTPA Gene

    230 amino acids
    Molecular mass:
    25566 Da
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Note=Binds 1 Mg(2+) ion per subunit.;
    Quaternary structure:
    • Monomer.

    Three dimensional structures from OCA and Proteopedia for THTPA Gene

    Alternative splice isoforms for THTPA Gene


neXtProt entry for THTPA Gene

Proteomics data for THTPA Gene at MOPED

Selected DME Specific Peptides for THTPA Gene

Post-translational modifications for THTPA Gene

  • Ubiquitination at Lys11 and Lys193
  • Modification sites at PhosphoSitePlus

Antibody Products

Domains for THTPA Gene

Protein Domains for THTPA Gene


Suggested Antigen Peptide Sequences for THTPA Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 CYTH domain.
  • Belongs to the ThTPase family.
  • Contains 1 CYTH domain.
  • Belongs to the ThTPase family.
genes like me logo Genes that share domains with THTPA: view

No data available for Gene Families for THTPA Gene

Function for THTPA Gene

Molecular function for THTPA Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=8 uM for thiamine triphosphate {ECO:0000269 PubMed:23707715}; Vmax=59 umol/min/mg enzyme {ECO:0000269 PubMed:23707715};
UniProtKB/Swiss-Prot CatalyticActivity:
Thiamine triphosphate + H(2)O = thiamine diphosphate + phosphate.
UniProtKB/Swiss-Prot Function:
Hydrolase highly specific for thiamine triphosphate (ThTP).

Enzyme Numbers (IUBMB) for THTPA Gene

Gene Ontology (GO) - Molecular Function for THTPA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000287 magnesium ion binding ISS --
GO:0016787 hydrolase activity TAS 11827967
GO:0050333 thiamin-triphosphatase activity TAS --
genes like me logo Genes that share ontologies with THTPA: view

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for THTPA

In Situ Assay Products

Flow Cytometry Products

No data available for Phenotypes , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for THTPA Gene

Localization for THTPA Gene

Subcellular locations from UniProtKB/Swiss-Prot for THTPA Gene


Subcellular locations from

Jensen Localization Image for THTPA Gene COMPARTMENTS Subcellular localization image for THTPA gene
Compartment Confidence
cytosol 4
nucleus 4
extracellular 2
mitochondrion 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for THTPA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with THTPA: view

Pathways for THTPA Gene

genes like me logo Genes that share pathways with THTPA: view

Interacting Proteins for THTPA Gene

Gene Ontology (GO) - Biological Process for THTPA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006091 generation of precursor metabolites and energy NAS 11827967
GO:0006766 vitamin metabolic process TAS --
GO:0006767 water-soluble vitamin metabolic process TAS --
GO:0006772 thiamine metabolic process TAS 11827967
GO:0016311 dephosphorylation IDA 11827967
genes like me logo Genes that share ontologies with THTPA: view

Drugs for THTPA Gene

(6) HMDB Compounds for THTPA Gene

Compound Synonyms Cas Number PubMed IDs
  • NFB Orthophosphate
Phosphoric acid
  • Acide phosphorique (FRENCH)
  • Aneurin
Thiamine pyrophosphate
  • Thaimine pyrophosphate
Thiamine triphosphate
  • Thiamin triphosphate

(3) Novoseek inferred chemical compound relationships for THTPA Gene

Compound -log(P) Hits PubMed IDs
thiamine triphosphate 98.3 7
thiamine 84.5 14
atp 12.7 1
genes like me logo Genes that share compounds with THTPA: view

Transcripts for THTPA Gene

Unigene Clusters for THTPA Gene

Thiamine triphosphatase:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for THTPA

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for THTPA Gene

No ASD Table

Relevant External Links for THTPA Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for THTPA Gene

mRNA expression in normal human tissues for THTPA Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for THTPA Gene

This gene is overexpressed in Ovary (9.1) and Seminal vesicle (7.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for THTPA Gene

SOURCE GeneReport for Unigene cluster for THTPA Gene Hs.655179

mRNA Expression by UniProt/SwissProt for THTPA Gene

Tissue specificity: Widely expressed but at a low level.
genes like me logo Genes that share expressions with THTPA: view

Expression partners for THTPA Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for THTPA Gene

Orthologs for THTPA Gene

This gene was present in the common ancestor of chordates.

Orthologs for THTPA Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia THTPA 35
  • 86.91 (n)
  • 84.47 (a)
  • 84 (a)
(Canis familiaris)
Mammalia THTPA 35
  • 86.67 (n)
  • 79.13 (a)
  • 79 (a)
(Mus musculus)
Mammalia Thtpa 35
  • 82.18 (n)
  • 74.65 (a)
Thtpa 16
Thtpa 36
  • 72 (a)
(Pan troglodytes)
Mammalia THTPA 35
  • 99.13 (n)
  • 98.26 (a)
  • 98 (a)
(Rattus norvegicus)
Mammalia Thtpa 35
  • 83.1 (n)
  • 73.73 (a)
(Monodelphis domestica)
Mammalia THTPA 36
  • 65 (a)
(Anolis carolinensis)
Reptilia THTPA 36
  • 44 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia thtpa 35
  • 53.27 (n)
  • 44.61 (a)
(Danio rerio)
Actinopterygii thtpa 35
  • 48.82 (n)
  • 39.9 (a)
thtpa 36
  • 32 (a)
Species with no ortholog for THTPA:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for THTPA Gene

Gene Tree for THTPA (if available)
Gene Tree for THTPA (if available)

Paralogs for THTPA Gene

No data available for Paralogs for THTPA Gene

Variants for THTPA Gene

Sequence variations from dbSNP and Humsavar for THTPA Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs570342592 -- 23,516,849(+) ACTTA(A/G)TGCAG intron-variant
rs570479744 -- 23,516,388(+) TATGC(A/G)TTTTG intron-variant
rs570500693 -- 23,513,418(+) GTGCG(C/T)GCATG intron-variant
rs570537278 -- 23,512,360(+) GAGGA(A/T)TCAAA intron-variant, upstream-variant-2KB
rs570569066 -- 23,517,424(+) GGTCT(A/G)CAGAC intron-variant

Relevant External Links for THTPA Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for THTPA Gene

Disorders for THTPA Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for THTPA Gene in MalaCards »

(1) Disease for THTPA Gene

(1) University of Copenhagen DISEASES for THTPA Gene

(1) Novoseek inferred disease relationships for THTPA Gene

Disease -log(P) Hits PubMed IDs
thiamine deficiency 71.9 2
genes like me logo Genes that share disorders with THTPA: view

No data available for OMIM , UniProtKB/Swiss-Prot , Genatlas and External Links for THTPA Gene

Publications for THTPA Gene

  1. Molecular characterization of a specific thiamine triphosphatase widely expressed in mammalian tissues. (PMID: 11827967) Lakaye B. … Bettendorff L. (J. Biol. Chem. 2002) 2 3 4 23
  2. The DNA sequence and analysis of human chromosome 14. (PMID: 12508121) Heilig R. … Weissenbach J. (Nature 2003) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. [The rate of molecular evolution of mammalian soluble thiamine triphosphatase]. (PMID: 20387656) Makarchikov A.F. (Ukr. Biokhim. Zh. 2009) 3 23
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for THTPA Gene

Sources for THTPA Gene

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