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Aliases for THTPA Gene

Aliases for THTPA Gene

  • Thiamine Triphosphatase 2 3
  • EC 3.6.1.28 4 63
  • THTPASE 3 4
  • THTP 3

External Ids for THTPA Gene

Previous GeneCards Identifiers for THTPA Gene

  • GC14P021397
  • GC14P017812
  • GC14P022015
  • GC14P023095
  • GC14P024025
  • GC14P004141
  • GC14P023548

Summaries for THTPA Gene

Entrez Gene Summary for THTPA Gene

  • This gene encodes an enzyme which catalyzes the biosynthesis of thiamine disphophate (vitamin B1) by hydrolysis of thiamine triphosphate. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2011]

GeneCards Summary for THTPA Gene

THTPA (Thiamine Triphosphatase) is a Protein Coding gene. Among its related pathways are Metabolism and Metabolism of vitamins and cofactors. GO annotations related to this gene include hydrolase activity and thiamin-triphosphatase activity.

UniProtKB/Swiss-Prot for THTPA Gene

  • Hydrolase highly specific for thiamine triphosphate (ThTP).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for THTPA Gene

Genomics for THTPA Gene

Regulatory Elements for THTPA Gene

Genomic Location for THTPA Gene

Chromosome:
14
Start:
23,511,760 bp from pter
End:
23,560,271 bp from pter
Size:
48,512 bases
Orientation:
Plus strand

Genomic View for THTPA Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for THTPA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for THTPA Gene

Proteins for THTPA Gene

  • Protein details for THTPA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BU02-THTPA_HUMAN
    Recommended name:
    Thiamine-triphosphatase
    Protein Accession:
    Q9BU02
    Secondary Accessions:
    • D3DS50
    • G3V4J3

    Protein attributes for THTPA Gene

    Size:
    230 amino acids
    Molecular mass:
    25566 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Note=Binds 1 Mg(2+) ion per subunit.;
    Quaternary structure:
    • Monomer.

    Three dimensional structures from OCA and Proteopedia for THTPA Gene

    Alternative splice isoforms for THTPA Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for THTPA Gene

Proteomics data for THTPA Gene at MOPED

Selected DME Specific Peptides for THTPA Gene

Post-translational modifications for THTPA Gene

  • Ubiquitination at Lys 11 and Lys 193
  • Modification sites at PhosphoSitePlus

Domains & Families for THTPA Gene

Protein Domains for THTPA Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for THTPA Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BU02

UniProtKB/Swiss-Prot:

THTPA_HUMAN :
  • Contains 1 CYTH domain.
  • Belongs to the ThTPase family.
Domain:
  • Contains 1 CYTH domain.
Family:
  • Belongs to the ThTPase family.
genes like me logo Genes that share domains with THTPA: view

No data available for Gene Families for THTPA Gene

Function for THTPA Gene

Molecular function for THTPA Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=8 uM for thiamine triphosphate {ECO:0000269 PubMed:23707715}; Vmax=59 umol/min/mg enzyme {ECO:0000269 PubMed:23707715};
UniProtKB/Swiss-Prot CatalyticActivity:
Thiamine triphosphate + H(2)O = thiamine diphosphate + phosphate.
UniProtKB/Swiss-Prot Function:
Hydrolase highly specific for thiamine triphosphate (ThTP).

Enzyme Numbers (IUBMB) for THTPA Gene

Gene Ontology (GO) - Molecular Function for THTPA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000287 magnesium ion binding ISS --
GO:0016787 hydrolase activity TAS 11827967
GO:0050333 thiamin-triphosphatase activity TAS --
genes like me logo Genes that share ontologies with THTPA: view

Phenotypes for THTPA Gene

GenomeRNAi human phenotypes for THTPA:
genes like me logo Genes that share phenotypes with THTPA: view

Animal Model Products

miRNA for THTPA Gene

miRTarBase miRNAs that target THTPA

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for THTPA

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for THTPA Gene

Localization for THTPA Gene

Subcellular locations from UniProtKB/Swiss-Prot for THTPA Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for THTPA Gene COMPARTMENTS Subcellular localization image for THTPA gene
Compartment Confidence
cytosol 4
mitochondrion 1

Gene Ontology (GO) - Cellular Components for THTPA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with THTPA: view

Pathways & Interactions for THTPA Gene

genes like me logo Genes that share pathways with THTPA: view

Interacting Proteins for THTPA Gene

Gene Ontology (GO) - Biological Process for THTPA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006091 generation of precursor metabolites and energy NAS 11827967
GO:0006766 vitamin metabolic process TAS --
GO:0006767 water-soluble vitamin metabolic process TAS --
GO:0006772 thiamine metabolic process TAS 11827967
GO:0016311 dephosphorylation IDA 11827967
genes like me logo Genes that share ontologies with THTPA: view

No data available for SIGNOR curated interactions for THTPA Gene

Drugs & Compounds for THTPA Gene

(3) Drugs for THTPA Gene - From: NovoSeek and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Thiamine Approved Nutra 82,82
thiamin diphosphate Experimental Pharma 0
ATP Pharma Activator 0

(4) Additional Compounds for THTPA Gene - From: NovoSeek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
thiamine triphosphate
  • Thiamin triphosphate
  • Thiamine triphosphate
  • ThTP
3475-65-8
Phosphate
  • NFB Orthophosphate
  • O-Phosphoric acid
  • Ortho-phosphate
  • Orthophosphate (PO43-)
  • Orthophosphate(3-)
14265-44-2
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
7664-38-2
Water
  • Dihydrogen oxide
  • Steam
7732-18-5
genes like me logo Genes that share compounds with THTPA: view

Transcripts for THTPA Gene

Unigene Clusters for THTPA Gene

Thiamine triphosphatase:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for THTPA

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for THTPA Gene

No ASD Table

Relevant External Links for THTPA Gene

GeneLoc Exon Structure for
THTPA
ECgene alternative splicing isoforms for
THTPA

Expression for THTPA Gene

mRNA expression in normal human tissues for THTPA Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for THTPA Gene

This gene is overexpressed in Ovary (9.1) and Seminal vesicle (7.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for THTPA Gene



SOURCE GeneReport for Unigene cluster for THTPA Gene Hs.655179

mRNA Expression by UniProt/SwissProt for THTPA Gene

Q9BU02-THTPA_HUMAN
Tissue specificity: Widely expressed but at a low level.
genes like me logo Genes that share expression patterns with THTPA: view

Protein tissue co-expression partners for THTPA Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for THTPA Gene

Orthologs for THTPA Gene

This gene was present in the common ancestor of chordates.

Orthologs for THTPA Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia THTPA 35
  • 86.91 (n)
  • 84.47 (a)
THTPA 36
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia THTPA 35
  • 86.67 (n)
  • 79.13 (a)
THTPA 36
  • 79 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Thtpa 35
  • 82.18 (n)
  • 74.65 (a)
Thtpa 16
Thtpa 36
  • 72 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia THTPA 35
  • 99.13 (n)
  • 98.26 (a)
THTPA 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Thtpa 35
  • 83.1 (n)
  • 73.73 (a)
oppossum
(Monodelphis domestica)
Mammalia THTPA 36
  • 65 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia THTPA 36
  • 44 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia thtpa 35
  • 53.27 (n)
  • 44.61 (a)
zebrafish
(Danio rerio)
Actinopterygii thtpa 35
  • 48.82 (n)
  • 39.9 (a)
thtpa 36
  • 32 (a)
OneToOne
Species with no ortholog for THTPA:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for THTPA Gene

ENSEMBL:
Gene Tree for THTPA (if available)
TreeFam:
Gene Tree for THTPA (if available)

Paralogs for THTPA Gene

No data available for Paralogs for THTPA Gene

Variants for THTPA Gene

Sequence variations from dbSNP and Humsavar for THTPA Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs222670 -- 23,515,634(+) CCCAG(C/T)GACTG intron-variant
rs222671 -- 23,516,764(+) GCAGA(A/G)GATGC intron-variant
rs222672 -- 23,516,984(+) ACCCC(A/G)GGTGC intron-variant
rs222673 -- 23,518,055(+) TTGGG(A/G)TATGT intron-variant
rs222674 -- 23,518,781(+) GAGAA(A/G)TACCA intron-variant

Variation tolerance for THTPA Gene

Residual Variation Intolerance Score: 23.75% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.38; 76.96% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for THTPA Gene

HapMap Linkage Disequilibrium report
THTPA

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for THTPA Gene

Disorders for THTPA Gene

Relevant External Links for THTPA

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
THTPA
genes like me logo Genes that share disorders with THTPA: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for THTPA Gene

Publications for THTPA Gene

  1. Molecular characterization of a specific thiamine triphosphatase widely expressed in mammalian tissues. (PMID: 11827967) Lakaye B. … Bettendorff L. (J. Biol. Chem. 2002) 2 23 67
  2. [The rate of molecular evolution of mammalian soluble thiamine triphosphatase]. (PMID: 20387656) Makarchikov A.F. (Ukr. Biokhim. Zh. 2009) 23 67
  3. The iron-regulated metastasis suppressor, Ndrg-1: identification of novel molecular targets. (PMID: 18582504) Kovacevic Z. … Richardson D.R. (Biochim. Biophys. Acta 2008) 23 67
  4. Structure of the class IV adenylyl cyclase reveals a novel fold. (PMID: 16905149) Gallagher D.T. … Reddy P.T. (J. Mol. Biol. 2006) 23 67
  5. Pig tissues express a catalytically inefficient 25-kDa thiamine triphosphatase: insight in the catalytic mechanisms of this enzyme. (PMID: 16000236) Szyniarowski P. … Bettendorff L. (Biochim. Biophys. Acta 2005) 23 67

Products for THTPA Gene

Sources for THTPA Gene

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