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Aliases for THSD7B Gene

Aliases for THSD7B Gene

  • Thrombospondin, Type I, Domain Containing 7B 2 3
  • KIAA1679 4

External Ids for THSD7B Gene

Previous GeneCards Identifiers for THSD7B Gene

  • GC02P137465
  • GC02P137356
  • GC02P137239
  • GC02P129738

Summaries for THSD7B Gene

GeneCards Summary for THSD7B Gene

THSD7B (Thrombospondin, Type I, Domain Containing 7B) is a Protein Coding gene. An important paralog of this gene is THSD7A.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for THSD7B Gene

Genomics for THSD7B Gene

Regulatory Elements for THSD7B Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for THSD7B Gene

Start:
136,765,545 bp from pter
End:
137,677,717 bp from pter
Size:
912,173 bases
Orientation:
Plus strand

Genomic View for THSD7B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for THSD7B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for THSD7B Gene

Proteins for THSD7B Gene

  • Protein details for THSD7B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9C0I4-THS7B_HUMAN
    Recommended name:
    Thrombospondin type-1 domain-containing protein 7B
    Protein Accession:
    Q9C0I4
    Secondary Accessions:

    Protein attributes for THSD7B Gene

    Size:
    1608 amino acids
    Molecular mass:
    179402 Da
    Quaternary structure:
    No Data Available

neXtProt entry for THSD7B Gene

Proteomics data for THSD7B Gene at MOPED

Post-translational modifications for THSD7B Gene

  • Glycosylation at Asn150, Asn190, Asn219, Asn683, Asn757, Asn842, Asn933, Asn1188, Asn1310, Asn1458, and Asn1526
  • Modification sites at PhosphoSitePlus

Other Protein References for THSD7B Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for THSD7B Gene

Domains for THSD7B Gene

Protein Domains for THSD7B Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for THSD7B Gene

Graphical View of Domain Structure for InterPro Entry

Q9C0I4

UniProtKB/Swiss-Prot:

THS7B_HUMAN :
  • Q9C0I4
Domain:
  • Contains 18 TSP type-1 domains.
genes like me logo Genes that share domains with THSD7B: view

No data available for Gene Families for THSD7B Gene

Function for THSD7B Gene

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for THSD7B Gene

Localization for THSD7B Gene

Subcellular locations from UniProtKB/Swiss-Prot for THSD7B Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for THSD7B Gene COMPARTMENTS Subcellular localization image for THSD7B gene
Compartment Confidence
extracellular 3
plasma membrane 3
endoplasmic reticulum 1
golgi apparatus 1
lysosome 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for THSD7B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with THSD7B: view

Pathways for THSD7B Gene

SuperPathways for THSD7B Gene

No Data Available

Interacting Proteins for THSD7B Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000272643%0d%0a9606.ENSP00000316589%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: ENSP00000272643 Q9C0I4-THS7B_HUMAN for THSD7B Gene via STRING I2D

Gene Ontology (GO) - Biological Process for THSD7B Gene

None

No data available for Pathways by source for THSD7B Gene

Transcripts for THSD7B Gene

mRNA/cDNA for THSD7B Gene

(12) Selected AceView cDNA sequences:
(4) Additional mRNA sequences :
(2) REFSEQ mRNAs :
(6) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for THSD7B Gene

Thrombospondin, type I, domain containing 7B:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for THSD7B

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for THSD7B

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for THSD7B Gene

No ASD Table

Relevant External Links for THSD7B Gene

GeneLoc Exon Structure for
THSD7B
ECgene alternative splicing isoforms for
THSD7B

Expression for THSD7B Gene

mRNA expression in normal human tissues for THSD7B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for THSD7B Gene

This gene is overexpressed in Artery - Aorta (6.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for THSD7B Gene

SOURCE GeneReport for Unigene cluster for THSD7B Gene Hs.68533

genes like me logo Genes that share expressions with THSD7B: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for THSD7B Gene

Orthologs for THSD7B Gene

This gene was present in the common ancestor of animals.

Orthologs for THSD7B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia THSD7B 35
  • 99.41 (n)
  • 98.98 (a)
THSD7B 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia THSD7B 35
  • 88.17 (n)
  • 87.69 (a)
THSD7B 36
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 36
  • 20 (a)
ManyToMany
THSD7B 35
  • 89 (n)
  • 89.49 (a)
mouse
(Mus musculus)
Mammalia Thsd7b 35
  • 84.52 (n)
  • 85.91 (a)
Thsd7b 16
Thsd7b 36
  • 86 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia THSD7B 36
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia THSD7B 36
  • 52 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Thsd7b 35
  • 84.48 (n)
  • 85.84 (a)
chicken
(Gallus gallus)
Aves THSD7B 35
  • 67.94 (n)
  • 66.08 (a)
THSD7B 36
  • 65 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia THSD7B 36
  • 66 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia thsd7b 35
  • 64.54 (n)
  • 62.32 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC566298 35
  • 60.04 (n)
  • 56.6 (a)
THSD7B (1 of 2) 36
  • 49 (a)
OneToMany
thsd7ba 36
  • 56 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG17739 36
  • 19 (a)
ManyToMany
CG30046 36
  • 13 (a)
ManyToMany
CG30203 36
  • 12 (a)
ManyToMany
fat-spondin 36
  • 17 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea spon-1 36
  • 18 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 25 (a)
OneToMany
Species with no ortholog for THSD7B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for THSD7B Gene

ENSEMBL:
Gene Tree for THSD7B (if available)
TreeFam:
Gene Tree for THSD7B (if available)

Paralogs for THSD7B Gene

Paralogs for THSD7B Gene

Selected SIMAP similar genes for THSD7B Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with THSD7B: view

Variants for THSD7B Gene

Sequence variations from dbSNP and Humsavar for THSD7B Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs91435 -- 137,597,267(-) CATAA(G/T)CTAAC intron-variant
rs113906 -- 136,901,030(+) ATAAT(C/G)TTTTA intron-variant
rs352174 -- 137,627,793(+) ATAAT(A/G)TGTAA intron-variant
rs352175 -- 137,636,173(+) TACAG(A/G)ACCTT intron-variant
rs352176 -- 137,647,825(+) CTGAG(G/T)CCAGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for THSD7B Gene

Variant ID Type Subtype PubMed ID
nsv875148 CNV Gain 21882294
nsv875151 CNV Loss 21882294
nsv875152 CNV Gain 21882294
nsv7329 OTHER Inversion 18451855
nsv525899 CNV Loss 19592680
nsv459474 CNV Loss 19166990
esv2657968 CNV Deletion 23128226
nsv526606 CNV Loss 19592680
nsv508169 CNV Loss 20534489
dgv4318n71 CNV Loss 21882294
esv2720868 CNV Deletion 23290073
esv32614 CNV Loss 17666407
esv275211 CNV Loss 21479260
nsv508872 CNV Insertion 20534489
esv2720869 CNV Deletion 23290073
esv1006423 CNV Deletion 20482838
esv1756709 CNV Insertion 17803354
esv1683117 CNV Deletion 17803354
esv2678344 CNV Deletion 23128226
esv2421943 CNV Deletion 20811451
nsv2944 CNV Loss 18451855
nsv875155 CNV Gain 21882294
esv2674548 CNV Deletion 23128226
nsv521939 CNV Loss 19592680
nsv875156 CNV Loss 21882294
esv33322 CNV Loss 17666407
nsv524693 CNV Loss 19592680
esv271476 CNV Insertion 20981092
esv2561082 CNV Insertion 19546169
esv271396 CNV Insertion 20981092
esv272358 CNV Insertion 20981092
nsv215433 CNV Loss 16902084
esv5744 CNV Loss 19470904
esv1274201 CNV Deletion 17803354
esv272939 CNV Insertion 20981092
esv268099 CNV Insertion 20981092
esv274289 CNV Insertion 20981092
esv2672484 CNV Deletion 23128226
esv271725 CNV Insertion 20981092
nsv875157 CNV Loss 21882294

Relevant External Links for THSD7B Gene

HapMap Linkage Disequilibrium report
THSD7B
Human Gene Mutation Database (HGMD)
THSD7B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for THSD7B Gene

Disorders for THSD7B Gene

Relevant External Links for THSD7B

Genetic Association Database (GAD)
THSD7B
Human Genome Epidemiology (HuGE) Navigator
THSD7B
genes like me logo Genes that share disorders with THSD7B: view

No data available for UniProtKB/Swiss-Prot for THSD7B Gene

Publications for THSD7B Gene

  1. Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11214970) Nagase T. … Ohara O. (DNA Res. 2000) 2 3 4
  2. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 3 4
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  4. Genome-wide association study of pancreatic cancer in Japanese population. (PMID: 20686608) Low S.K. … Sakamoto H. (PLoS ONE 2010) 3
  5. A meta-analysis of two genome-wide association studies identifies 3 new loci for alcohol dependence. (PMID: 21703634) Wang K.S. … Zeng M. (J Psychiatr Res 2011) 3

Products for THSD7B Gene

Sources for THSD7B Gene

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