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Aliases for THSD7A Gene

Aliases for THSD7A Gene

  • Thrombospondin, Type I, Domain Containing 7A 2 3
  • KIAA0960 4 6

External Ids for THSD7A Gene

Summaries for THSD7A Gene

Entrez Gene Summary for THSD7A Gene

  • The protein encoded by this gene is found almost exclusively in endothelial cells from placenta and umbilical cord. The encoded protein appears to interact with alpha(V)beta(3) integrin and paxillin to inhibit endothelial cell migration and tube formation. This protein may be involved in cytoskeletal organization. Variations in this gene may be associated with low bone mineral density in osteoporosis. [provided by RefSeq, Aug 2010]

GeneCards Summary for THSD7A Gene

THSD7A (Thrombospondin, Type I, Domain Containing 7A) is a Protein Coding gene. Diseases associated with THSD7A include osteoporosis. An important paralog of this gene is SPON2.

UniProtKB/Swiss-Prot for THSD7A Gene

  • The soluble form promotes endothelial cell migration and filopodia formationduring angiogenesis via a FAK-dependent mechanism.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for THSD7A Gene

Genomics for THSD7A Gene

Genomic Location for THSD7A Gene

Start:
11,370,357 bp from pter
End:
11,832,198 bp from pter
Size:
461,842 bases
Orientation:
Minus strand

Genomic View for THSD7A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for THSD7A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for THSD7A Gene

Regulatory Elements for THSD7A Gene

Proteins for THSD7A Gene

  • Protein details for THSD7A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UPZ6-THS7A_HUMAN
    Recommended name:
    Thrombospondin type-1 domain-containing protein 7A
    Protein Accession:
    Q9UPZ6
    Secondary Accessions:

    Protein attributes for THSD7A Gene

    Size:
    1657 amino acids
    Molecular mass:
    185363 Da
    Quaternary structure:
    No Data Available

neXtProt entry for THSD7A Gene

Proteomics data for THSD7A Gene at MOPED

Post-translational modifications for THSD7A Gene

  • Extensively N-glycosylated.
  • Proteolytic cleavage in the extracellular region generates a 210 kDa soluble form.
  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn234, Asn332, Asn450, Asn500, Asn679, Asn717, Asn968, Asn1043, Asn1182, Asn1225, Asn1276, Asn1366, Asn1500, and Asn1547

Other Protein References for THSD7A Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for THSD7A Gene

Domains for THSD7A Gene

Protein Domains for THSD7A Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

THS7A_HUMAN
Domain:
  • Contains 15 TSP type-1 domains.:
    • Q9UPZ6
genes like me logo Genes that share domains with THSD7A: view

No data available for Gene Families for THSD7A Gene

Function for THSD7A Gene

Molecular function for THSD7A Gene

UniProtKB/Swiss-Prot Function: The soluble form promotes endothelial cell migration and filopodia formationduring angiogenesis via a FAK-dependent mechanism.

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for THSD7A Gene

Localization for THSD7A Gene

Subcellular locations from UniProtKB/Swiss-Prot for THSD7A Gene

Cell membrane; Single-pass type I membrane protein. Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for THSD7A Gene COMPARTMENTS Subcellular localization image for THSD7A gene
Compartment Confidence
extracellular 5
plasma membrane 5
cytoskeleton 1
lysosome 1
nucleus 1

Gene Ontology (GO) - Cellular Components for THSD7A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with THSD7A: view

Pathways for THSD7A Gene

SuperPathways for THSD7A Gene

No Data Available

Interacting Proteins for THSD7A Gene

Gene Ontology (GO) - Biological Process for THSD7A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis IEA --
GO:0030154 cell differentiation IEA --
genes like me logo Genes that share ontologies with THSD7A: view

No data available for Pathways by source for THSD7A Gene

Transcripts for THSD7A Gene

mRNA/cDNA for THSD7A Gene

(8) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for THSD7A Gene

Thrombospondin, type I, domain containing 7A:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for THSD7A Gene

No ASD Table

Relevant External Links for THSD7A Gene

GeneLoc Exon Structure for
THSD7A
ECgene alternative splicing isoforms for
THSD7A

Expression for THSD7A Gene

mRNA expression in normal human tissues for THSD7A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for THSD7A Gene

SOURCE GeneReport for Unigene cluster for THSD7A Gene Hs.120855

genes like me logo Genes that share expressions with THSD7A: view

Orthologs for THSD7A Gene

This gene was present in the common ancestor of animals.

Orthologs for THSD7A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia THSD7A 36
  • 99.5 (n)
  • 99.58 (a)
THSD7A 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia THSD7A 36
  • 89.19 (n)
  • 91.92 (a)
THSD7A 37
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia THSD7A 36
  • 91.04 (n)
  • 94.08 (a)
THSD7A 37
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Thsd7a 36
  • 86.49 (n)
  • 91.13 (a)
Thsd7a 16
Thsd7a 37
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia THSD7A 37
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia THSD7A 37
  • 74 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Thsd7a 36
  • 86.83 (n)
  • 91.61 (a)
chicken
(Gallus gallus)
Aves THSD7A 36
  • 78.39 (n)
  • 83.63 (a)
THSD7A 37
  • 82 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia THSD7A 37
  • 79 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia thsd7a 36
  • 73.98 (n)
  • 78.54 (a)
zebrafish
(Danio rerio)
Actinopterygii thsd7a 36
  • 67.18 (n)
  • 71.04 (a)
thsd7a 37
  • 69 (a)
OneToMany
THSD7A (2 of 2) 37
  • 63 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG17739 37
  • 18 (a)
ManyToMany
CG30046 37
  • 13 (a)
ManyToMany
CG30203 37
  • 11 (a)
ManyToMany
fat-spondin 37
  • 17 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea spon-1 37
  • 16 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 39 (a)
ManyToMany
-- 37
  • 36 (a)
ManyToMany
-- 37
  • 37 (a)
ManyToMany
CSA.10186 37
  • 37 (a)
ManyToMany
Species with no ortholog for THSD7A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for THSD7A Gene

ENSEMBL:
Gene Tree for THSD7A (if available)
TreeFam:
Gene Tree for THSD7A (if available)

Paralogs for THSD7A Gene

Paralogs for THSD7A Gene

Selected SIMAP similar genes for THSD7A Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with THSD7A: view

Variants for THSD7A Gene

Sequence variations from dbSNP and Humsavar for THSD7A Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs15 -- 11,563,305(-) GAAGC(A/G)CATTA intron-variant
rs16 -- 11,563,272(-) GCATT(A/G)TTTTA intron-variant
rs17 -- 11,544,172(-) tagag(A/T)cgggg intron-variant
rs18 -- 11,557,848(-) ggtgt(C/T)agaga intron-variant
rs19 -- 11,557,529(-) tgggt(C/T)tcaat intron-variant

Structural Variations from Database of Genomic Variants (DGV) for THSD7A Gene

Variant ID Type Subtype PubMed ID
dgv405n21 CNV Gain 19592680
nsv830902 CNV Gain 17160897
nsv830903 CNV Gain 17160897
esv2672996 CNV Deletion 23128226
nsv525858 CNV Loss 19592680
nsv887606 CNV Gain 21882294
nsv887607 CNV Loss 21882294
nsv523264 CNV Loss 19592680
nsv464366 CNV Loss 19166990
nsv527252 CNV Loss 19592680
nsv464367 CNV Loss 19166990
nsv887608 CNV Loss 21882294
dgv7187n71 CNV Loss 21882294
esv2408291 CNV Deletion 18987734
esv2733974 CNV Deletion 23290073
esv2674412 CNV Deletion 23128226
nsv510069 CNV Loss 20534489
esv28198 CNV Gain 19812545
esv2663598 CNV Deletion 23128226
esv2733975 CNV Deletion 23290073
dgv1123e201 CNV Deletion 23290073
nsv887611 CNV Loss 21882294
nsv510070 CNV Loss 20534489
dgv7188n71 CNV Loss 21882294
nsv524308 CNV Loss 19592680
nsv887614 CNV Gain 21882294
esv274953 CNV Gain+Loss 21479260
nsv525415 CNV Loss 19592680
nsv830905 CNV Loss 17160897
esv270634 CNV Insertion 20981092
nsv887615 CNV Loss 21882294

Relevant External Links for THSD7A Gene

HapMap Linkage Disequilibrium report
THSD7A
Human Gene Mutation Database (HGMD)
THSD7A

Disorders for THSD7A Gene

(1) MalaCards Diseases for THSD7A Gene

Search for THSD7A Gene in MalaCards »

Relevant External Links for THSD7A

Genetic Association Database (GAD)
THSD7A
Human Genome Epidemiology (HuGE) Navigator
THSD7A
genes like me logo Genes that share disorders with THSD7A: view

No data available for UniProtKB/Swiss-Prot for THSD7A Gene

Publications for THSD7A Gene

  1. Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10231032) Nagase T. … Ohara O. (DNA Res. 1999) 3 4
  2. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PMID: 12168954) Nakajima D. … Nagase T. (DNA Res. 2002) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. Association of genetic variations of genes encoding thrombospondin, type 1, domain-containing 4 and 7A with low bone mineral density in Japanese women with osteoporosis. (PMID: 18488137) Mori S. … Ikegawa S. (J. Hum. Genet. 2008) 3 49
  5. Soluble THSD7A is an N-glycoprotein that promotes endothelial cell migration and tube formation in angiogenesis. (PMID: 22194972) Kuo M.W. … Chuang Y.J. (PLoS ONE 2011) 3 4

Products for THSD7A Gene

Sources for THSD7A Gene

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