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THSD7A Gene

protein-coding   GIFtS: 50
GCID: GC07M011381

Thrombospondin, Type I, Domain Containing 7A

  See THSD7A-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Thrombospondin, Type I, Domain Containing 7A1 2
KIAA09603 5
Thrombospondin Type-1 Domain-Containing Protein 7A2

External Ids:    HGNC: 222071   Entrez Gene: 2219812   Ensembl: ENSG000000051087   OMIM: 6122495   UniProtKB: Q9UPZ63   

Export aliases for THSD7A gene to outside databases

Previous GC identifer: GC07M011268


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for THSD7A Gene:
The protein encoded by this gene is found almost exclusively in endothelial cells from placenta and umbilical
cord. The encoded protein appears to interact with alpha(V)beta(3) integrin and paxillin to inhibit endothelial
cell migration and tube formation. This protein may be involved in cytoskeletal organization. Variations in this
gene may be associated with low bone mineral density in osteoporosis. (provided by RefSeq, Aug 2010)

GeneCards Summary for THSD7A Gene:
THSD7A (thrombospondin, type I, domain containing 7A) is a protein-coding gene. Diseases associated with THSD7A include osteoporosis. An important paralog of this gene is SPON2.

UniProtKB/Swiss-Prot: THS7A_HUMAN, Q9UPZ6
Function: The soluble form promotes endothelial cell migration and filopodia formationduring angiogenesis via a
FAK-dependent mechanism




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000007.13  NT_007819.18  NC_018918.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the THSD7A gene promoter:
         STAT5B   AML1a   STAT6   XBP-1   AREB6   POU2F1   POU2F1a   IRF-7A   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for THSD7A

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat THSD7A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p21.3   Ensembl cytogenetic band:  7p21.3   HGNC cytogenetic band: 7p21.3

THSD7A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
THSD7A gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M011381:  view genomic region     (about GC identifiers)

Start:
11,409,984 bp from pter      End:
11,871,824 bp from pter
Size:
461,841 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 11,463,461-11,925,090     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: THS7A_HUMAN, Q9UPZ6 (See protein sequence)
Recommended Name: Thrombospondin type-1 domain-containing protein 7A precursor  
Size: 1657 amino acids; 185363 Da

Explore the universe of human proteins at neXtProt for THSD7A: NX_Q9UPZ6

Explore proteomics data for THSD7A at MOPED

Post-translational modifications: 

  • Proteolytic cleavage in the extracellular region generates a 210 kDa soluble form1
  • Extensively N-glycosylated1
  • Glycosylation2 at Asn234, Asn332, Asn450, Asn500, Asn679, Asn717, Asn968, Asn1043, Asn1182, Asn1225,
                                 Asn1276, Asn1366, Asn1500, Asn1547
  • Modification sites at PhosphoSitePlus

  • See THSD7A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_056019.1  
    ENSEMBL proteins: 
     ENSP00000406482  
    Reactome Protein details: Q9UPZ6

    THSD7A Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for THSD7A

     
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    THSD7A Assay Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR000884 Thrombospondin_1_rpt

    Graphical View of Domain Structure for InterPro Entry Q9UPZ6

    ProtoNet protein and cluster: Q9UPZ6

    UniProtKB/Swiss-Prot: THS7A_HUMAN, Q9UPZ6
    Similarity: Contains 15 TSP type-1 domains


    Find genes that share domains with THSD7A           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: THS7A_HUMAN, Q9UPZ6
    Function: The soluble form promotes endothelial cell migration and filopodia formationduring angiogenesis via a
    FAK-dependent mechanism

    Animal Models:

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    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate THSD7A (see all 106):
    hsa-miR-323-3p hsa-miR-548j hsa-miR-607 hsa-miR-200a hsa-miR-1273d hsa-miR-3613-3p hsa-miR-548a-5p hsa-miR-376c
    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    Gene Editing
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    THS7A_HUMAN, Q9UPZ6: Cell membrane; Single-pass type I membrane protein. Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    plasma membrane5
    cytoskeleton1
    lysosome1
    nucleus1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--
    GO:0005886plasma membrane IEA--
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with THSD7A           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Find genes that share SuperPaths with THSD7A           About GenesLikeMe

    Pathways by sourceSee SuperPaths
    Show all pathways


    1 Reactome Pathway for THSD7A
        O-glycosylation of TSR domain-containing proteins


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for THSD7A
    Interactions:

        Search GeneGlobe Interaction Network for THSD7A

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    4 Interacting proteins for THSD7A (Q9UPZ62, 3 ENSP000004064824) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SKILP127572, 3MINT-61682 I2D: score=2 
    ASAP2O431503, ENSP000002814194I2D: score=1 STRING: ENSP00000281419
    RANBP10ENSP000003165894STRING: ENSP00000316589
    REG3AENSP000003043114STRING: ENSP00000304311
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    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001525angiogenesis IEA--
    GO:0030154cell differentiation IEA--

    Find genes that share ontologies with THSD7A           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for THSD7A (THS7A)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for THSD7A gene: 
    NM_015204.2  

    Unigene Cluster for THSD7A:

    Thrombospondin, type I, domain containing 7A
    Hs.120855  [show with all ESTs]
    Unigene Representative Sequence: NM_015204
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000423059(uc003ssd.4 uc021zzn.1 uc021zzo.1) ENST00000408005
    ENST00000497575 ENST00000480061
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat THSD7A using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate THSD7A (see all 106):
    hsa-miR-323-3p hsa-miR-548j hsa-miR-607 hsa-miR-200a hsa-miR-1273d hsa-miR-3613-3p hsa-miR-548a-5p hsa-miR-376c
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Primer
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      QuantiFast Probe-based Assays in human, mouse, rat THSD7A

    Additional mRNA sequence: 

    AB023177.2 AK001884.1 AK092252.1 BC016980.2 BC030083.1 

    5 DOTS entries:

    DT.91945354  DT.85100740  DT.97836225  DT.91923370  DT.439769 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    THSD7A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGAAGATGTA
    THSD7A Expression
    About this image


    THSD7A expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Neural Tube (Nervous System)    fully expand to see all 5 entries
             Metencephalon
     
     Eye (Sensory Organs)    fully expand to see all 2 entries
             Mature Horizontal Cells Inner Nuclear Layer
             Retina
     
     Epithelial Cells
             Podocytes Podocyte Layer
     
     Kidney (Urinary System)
             Podocytes Podocyte Layer
     
     Neurons
             Mature Horizontal Cells Inner Nuclear Layer
    THSD7A Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    THSD7A Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.120855
        Custom PCR Arrays for THSD7A
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for THSD7A

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for THSD7A gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Thsd7a1 , 5 thrombospondin, type I, domain containing 7A1, 5 86.49(n)1
    91.13(a)1
      6 (5.31 cM)5
    3302671  NM_001164805.11  NP_001158277.11 
     123170875 
    chicken
    (Gallus gallus)
    Aves THSD7A1 thrombospondin, type I, domain containing 7A 78.39(n)
    83.63(a)
      420585  XM_418686.3  XP_418686.3 
    lizard
    (Anolis carolinensis)
    Reptilia THSD7A6
    thrombospondin, type I, domain containing 7A
    79(a)
    1 ↔ 1
    6(25222845-25549529)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia thsd7a1 thrombospondin, type I, domain containing 7A 73.98(n)
    78.54(a)
      100495599  XM_002939012.2  XP_002939058.2 
    zebrafish
    (Danio rerio)
    Actinopterygii thsd7a1 thrombospondin, type I, domain containing 7A 67.18(n)
    71.04(a)
      557991  NM_001122760.1  NP_001116232.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG177396
    fat-spondin6
    (see all 4)
    fat-spondin
    (see all 4)
    18(a)
    17(a)
    (see all 4)
    many ↔ many
    many ↔ many
    (see all 4)
    2R(8194029-8197917)
    2R(12941508-12946810)
    worm
    (Caenorhabditis elegans)
    Secernentea spon-16
    Protein SPON-1 (spon-1) mRNA, complete cds
    16(a)
    1 → many
    II(7116571-7120542) WBGene00006893


    ENSEMBL Gene Tree for THSD7A (if available)
    TreeFam Gene Tree for THSD7A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for THSD7A gene
    SPON22  THSD7B2  
    1 SIMAP similar gene for THSD7A using alignment to 1 protein entry:     THS7A_HUMAN:
    THSD7B

    Find genes that share paralogs with THSD7A           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for THSD7A (see all 11166)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs17178661,2
    C--11320741(-) accccG/Atctct 1 -- int11Minor allele frequency- A:0.50NA 2
    rs1489433041,2
    --11385457(+) AGCTAC/TTTCAG 1 -- ds50010--------
    rs1151676841,2
    F--11385488(+) TACCCC/TGGAAG 1 -- ds50011Minor allele frequency- T:0.01WA 118
    rs1848977341,2
    --11385559(+) ACTTTC/TAGGTT 1 -- ds50010--------
    rs1436625951,2
    --11385640(+) AAGCTA/GTACTC 1 -- ds50010--------
    rs576038521,2
    --11385798(+) TTATAC/TAACCC 1 -- ds50010--------
    rs1417991821,2
    --11385811(+) GAAAGA/GGCAAT 1 -- ds50010--------
    rs736759811,2
    C,F--11385826(+) TAGGTG/AAAAGG 1 -- ds50011Minor allele frequency- A:0.50WA 2
    rs1146123801,2
    C--11386072(+) TGTACA/GTAGAC 1 -- ut310--------
    rs1168953551,2
    C,F--11386307(+) TCTCTT/CCAAAT 1 -- ut311Minor allele frequency- C:0.02EA 120

    HapMap Linkage Disequilibrium report for THSD7A (11409984 - 11659984 bp, first 250kb of THSD7A)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for THSD7A (see all 31):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2408291CNV Deletion18987734
    esv2672996CNV Deletion23128226
    dgv1123e201CNV Deletion23290073
    esv2733974CNV Deletion23290073
    esv2733975CNV Deletion23290073
    esv2663598CNV Deletion23128226
    esv2674412CNV Deletion23128226
    esv270634CNV Insertion20981092
    nsv464367CNV Loss19166990
    nsv887615CNV Loss21882294

    Human Gene Mutation Database (HGMD): THSD7A
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing THSD7A
    DNA2.0 Custom Variant and Variant Library Synthesis for THSD7A

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 612249    OMIM disorders: --

    1 disease for THSD7A:    
    About MalaCards
    osteoporosis


    Find genes that share disorders with THSD7A           About GenesLikeMe

    Genetic Association Database (GAD): THSD7A
    Human Genome Epidemiology (HuGE) Navigator: THSD7A (4 documents)

    Export disorders for THSD7A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for THSD7A gene, integrated from 10 sources (see all 25):
    (articles sorted by number of sources associating them with THSD7A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Soluble THSD7A is an N-glycoprotein that promotes endothelial cell migration and tube formation in angiogenesis. (PubMed id 22194972)1, 2 Kuo M.W.... Chuang Y.J. (PLoS ONE 2011)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    3. Family-based association study for bipolar affective disorder. (PubMed id 20414141)1, 4 Secolin R....Lopes-Cendes I. (Psychiatr. Genet. 2010)
    4. Novel association strategy with copy number variation for identifying new risk Loci of human diseases. (PubMed id 20808825)1, 4 Chen X....Kong X. (PLoS ONE 2010)
    5. Association of genetic variations of genes encoding thrombospondin, type 1, domain-containing 4 and 7A with low bone mineral density in Japanese women with osteoporosis. (PubMed id 18488137)1, 4 Mori S....Ikegawa S. (J. Hum. Genet. 2008)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    7. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PubMed id 12168954)1, 2 Nakajima D.... Nagase T. (DNA Res. 2002)
    8. Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10231032)1, 2 Nagase T.... Ohara O. (DNA Res. 1999)
    9. Genome-wide association study of Tourette's syndrome. (PubMed id 22889924)1 Scharf J.M....Pauls D.L. (Mol. Psychiatry 2013)
    10. Association of the formiminotransferase N-terminal sub-domain containing gene and thrombospondin, type 1, domain-containing 7A gene with the prevalence of vertebral fracture in 2427 consecutive autopsy cases. (PubMed id 23303384)1 Zhou H....Ito H. (J. Hum. Genet. 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 221981 HGNC: 22207 Ensembl:ENSG00000005108 euGenes: HUgn221981 ECgene: THSD7A
    H-InvDB: THSD7A

    (According to HUGE)
    About This Section

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    HUGE: KIAA0960

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for THSD7A Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for THSD7A gene:
    Search GeneIP for patents involving THSD7A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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