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Aliases for THSD7A Gene

Aliases for THSD7A Gene

  • Thrombospondin Type 1 Domain Containing 7A 2 3 5
  • KIAA0960 4

External Ids for THSD7A Gene

Previous GeneCards Identifiers for THSD7A Gene

  • GC07M011268

Summaries for THSD7A Gene

Entrez Gene Summary for THSD7A Gene

  • The protein encoded by this gene is found almost exclusively in endothelial cells from placenta and umbilical cord. The encoded protein appears to interact with alpha(V)beta(3) integrin and paxillin to inhibit endothelial cell migration and tube formation. This protein may be involved in cytoskeletal organization. Variations in this gene may be associated with low bone mineral density in osteoporosis. [provided by RefSeq, Aug 2010]

GeneCards Summary for THSD7A Gene

THSD7A (Thrombospondin Type 1 Domain Containing 7A) is a Protein Coding gene. Diseases associated with THSD7A include Membranous Nephropathy and Osteoporosis. Among its related pathways are O-glycosylation of TSR domain-containing proteins and HIV Life Cycle. An important paralog of this gene is THSD7B.

UniProtKB/Swiss-Prot for THSD7A Gene

  • The soluble form promotes endothelial cell migration and filopodia formationduring angiogenesis via a FAK-dependent mechanism.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for THSD7A Gene

Genomics for THSD7A Gene

Regulatory Elements for THSD7A Gene

Enhancers for THSD7A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07F012111 1.3 Ensembl ENCODE 14.5 -279.6 -279554 1.1 CTCF RNF2 RAD21 ZBTB20 THSD7A GC07M012122 PIR44967
GH07F012210 0.4 ENCODE 8.6 -379.2 -379236 2.8 HDGF PKNOX1 ARNT CREB3L1 WRNIP1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 TMEM106B THSD7A VWDE GC07M012369
GH07F011820 0.3 FANTOM5 7.5 +12.0 12024 0.3 THSD7A LOC100421595 GC07P011685
GH07F012093 0.6 ENCODE 6.6 -262.3 -262290 1.0 JUND BCL11A POLR2A MAX KDM1A THSD7A GC07M012122 PIR44967
GH07F011539 1 Ensembl ENCODE 5.3 +292.0 291973 1.6 CEBPB MAX REST RAD21 SMARCA4 FOXP2 MAFK MYC THSD7A LOC105375151 GC07M011498
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around THSD7A on UCSC Golden Path with GeneCards custom track

Promoters for THSD7A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000621989 597 1999 CTCF SIN3A RAD21 YY1 ZFHX2 GLIS2 POLR2A PATZ1 ZBTB20 EGR2

Genomic Location for THSD7A Gene

Chromosome:
7
Start:
11,370,357 bp from pter
End:
11,832,198 bp from pter
Size:
461,842 bases
Orientation:
Minus strand

Genomic View for THSD7A Gene

Genes around THSD7A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
THSD7A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for THSD7A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for THSD7A Gene

Proteins for THSD7A Gene

  • Protein details for THSD7A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UPZ6-THS7A_HUMAN
    Recommended name:
    Thrombospondin type-1 domain-containing protein 7A
    Protein Accession:
    Q9UPZ6

    Protein attributes for THSD7A Gene

    Size:
    1657 amino acids
    Molecular mass:
    185363 Da
    Quaternary structure:
    No Data Available

neXtProt entry for THSD7A Gene

Post-translational modifications for THSD7A Gene

Other Protein References for THSD7A Gene

No data available for DME Specific Peptides for THSD7A Gene

Domains & Families for THSD7A Gene

Protein Domains for THSD7A Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for THSD7A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UPZ6

UniProtKB/Swiss-Prot:

THS7A_HUMAN :
  • Contains 15 TSP type-1 domains.
Domain:
  • Contains 15 TSP type-1 domains.
genes like me logo Genes that share domains with THSD7A: view

No data available for Gene Families for THSD7A Gene

Function for THSD7A Gene

Molecular function for THSD7A Gene

UniProtKB/Swiss-Prot Function:
The soluble form promotes endothelial cell migration and filopodia formationduring angiogenesis via a FAK-dependent mechanism.

Phenotypes for THSD7A Gene

genes like me logo Genes that share phenotypes with THSD7A: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for THSD7A Gene

Localization for THSD7A Gene

Subcellular locations from UniProtKB/Swiss-Prot for THSD7A Gene

Cell membrane; Single-pass type I membrane protein. Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for THSD7A Gene COMPARTMENTS Subcellular localization image for THSD7A gene
Compartment Confidence
extracellular 5
plasma membrane 5
lysosome 1
nucleus 1
vacuole 1

Gene Ontology (GO) - Cellular Components for THSD7A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with THSD7A: view

Pathways & Interactions for THSD7A Gene

genes like me logo Genes that share pathways with THSD7A: view

Interacting Proteins for THSD7A Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000406482%0d%0a9606.ENSP00000281419%0d%0a9606.ENSP00000011619%0d%0a9606.ENSP00000304311%0d%0a
Selected Interacting proteins: Q9UPZ6-THS7A_HUMAN ENSP00000406482 for THSD7A Gene via MINT STRING IID

Gene Ontology (GO) - Biological Process for THSD7A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis IEA --
GO:0030154 cell differentiation IEA --
genes like me logo Genes that share ontologies with THSD7A: view

No data available for SIGNOR curated interactions for THSD7A Gene

Transcripts for THSD7A Gene

mRNA/cDNA for THSD7A Gene

(6) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for THSD7A Gene

Thrombospondin, type I, domain containing 7A:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for THSD7A Gene

No ASD Table

Relevant External Links for THSD7A Gene

GeneLoc Exon Structure for
THSD7A
ECgene alternative splicing isoforms for
THSD7A

Expression for THSD7A Gene

mRNA expression in normal human tissues for THSD7A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for THSD7A Gene

This gene is overexpressed in Fetal Brain (24.8), Gallbladder (9.2), Platelet (7.1), and Retina (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for THSD7A Gene



NURSA nuclear receptor signaling pathways regulating expression of THSD7A Gene:

THSD7A

SOURCE GeneReport for Unigene cluster for THSD7A Gene:

Hs.120855
genes like me logo Genes that share expression patterns with THSD7A: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for THSD7A Gene

Orthologs for THSD7A Gene

This gene was present in the common ancestor of animals.

Orthologs for THSD7A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia THSD7A 34 35
  • 99.5 (n)
dog
(Canis familiaris)
Mammalia THSD7A 34 35
  • 91.04 (n)
cow
(Bos Taurus)
Mammalia THSD7A 34 35
  • 89.19 (n)
rat
(Rattus norvegicus)
Mammalia Thsd7a 34
  • 86.83 (n)
mouse
(Mus musculus)
Mammalia Thsd7a 34 16 35
  • 86.49 (n)
oppossum
(Monodelphis domestica)
Mammalia THSD7A 35
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia THSD7A 35
  • 74 (a)
OneToOne
chicken
(Gallus gallus)
Aves THSD7A 34 35
  • 78.39 (n)
lizard
(Anolis carolinensis)
Reptilia THSD7A 35
  • 79 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia thsd7a 34
  • 73.98 (n)
zebrafish
(Danio rerio)
Actinopterygii thsd7a 34 35
  • 67.18 (n)
THSD7A (2 of 2) 35
  • 63 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG17739 35
  • 18 (a)
ManyToMany
fat-spondin 35
  • 17 (a)
ManyToMany
CG30046 35
  • 13 (a)
ManyToMany
CG30203 35
  • 11 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea spon-1 35
  • 16 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 39 (a)
ManyToMany
-- 35
  • 37 (a)
ManyToMany
CSA.10186 35
  • 37 (a)
ManyToMany
-- 35
  • 36 (a)
ManyToMany
Species where no ortholog for THSD7A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for THSD7A Gene

ENSEMBL:
Gene Tree for THSD7A (if available)
TreeFam:
Gene Tree for THSD7A (if available)

Paralogs for THSD7A Gene

Paralogs for THSD7A Gene

(1) SIMAP similar genes for THSD7A Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with THSD7A: view

Variants for THSD7A Gene

Sequence variations from dbSNP and Humsavar for THSD7A Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs10046496 -- 11,567,241(+) gtgga(A/G)ggtga intron-variant, nc-transcript-variant
rs10046497 -- 11,567,257(+) AAGCA(A/G)GACAC intron-variant, nc-transcript-variant
rs10046587 -- 11,569,682(+) ctgaa(A/G)gaaag intron-variant
rs10081319 -- 11,450,435(+) GTTAT(C/G)CAAAC intron-variant
rs10085466 -- 11,682,608(+) taaaa(C/T)gatta intron-variant

Structural Variations from Database of Genomic Variants (DGV) for THSD7A Gene

Variant ID Type Subtype PubMed ID
dgv1076e201 CNV deletion 23290073
dgv405n21 CNV gain 19592680
dgv6267n100 CNV loss 25217958
dgv6268n100 CNV loss 25217958
dgv6269n100 CNV loss 25217958
dgv6270n100 CNV loss 25217958
esv2408291 CNV deletion 18987734
esv2663598 CNV deletion 23128226
esv2672996 CNV deletion 23128226
esv2674412 CNV deletion 23128226
esv2733974 CNV deletion 23290073
esv2733975 CNV deletion 23290073
esv274953 CNV gain+loss 21479260
esv2762651 CNV loss 21179565
esv2763620 CNV loss 21179565
esv28198 CNV gain 19812545
esv3306357 CNV mobile element insertion 20981092
esv3357619 CNV insertion 20981092
esv3541184 CNV deletion 23714750
esv3571639 CNV loss 25503493
esv3571640 CNV loss 25503493
esv3612214 CNV loss 21293372
esv3612216 CNV loss 21293372
esv3612217 CNV loss 21293372
esv3612218 CNV loss 21293372
esv3612219 CNV loss 21293372
esv3612220 CNV loss 21293372
esv3612221 CNV loss 21293372
esv3612222 CNV gain 21293372
esv3612223 CNV loss 21293372
esv3612224 CNV loss 21293372
esv3612227 CNV loss 21293372
esv3891050 CNV gain 25118596
esv3891052 CNV loss 25118596
esv3891053 CNV loss 25118596
nsv1016834 CNV loss 25217958
nsv1019888 CNV gain 25217958
nsv1020765 CNV gain 25217958
nsv1023665 CNV loss 25217958
nsv1025802 CNV loss 25217958
nsv1028614 CNV loss 25217958
nsv1032865 CNV loss 25217958
nsv1148435 CNV deletion 26484159
nsv464366 CNV loss 19166990
nsv464367 CNV loss 19166990
nsv510069 OTHER sequence alteration 20534489
nsv510070 OTHER sequence alteration 20534489
nsv523264 CNV loss 19592680
nsv524308 CNV loss 19592680
nsv525415 CNV loss 19592680
nsv525858 CNV loss 19592680
nsv527252 CNV loss 19592680
nsv606187 CNV gain 21841781
nsv606199 CNV gain 21841781
nsv606200 CNV loss 21841781
nsv606201 CNV loss 21841781
nsv606202 CNV gain 21841781
nsv606203 CNV loss 21841781
nsv830902 CNV gain 17160897
nsv830903 CNV gain 17160897
nsv830905 CNV loss 17160897
nsv970796 CNV duplication 23825009

Variation tolerance for THSD7A Gene

Residual Variation Intolerance Score: 8.91% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.88; 91.84% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for THSD7A Gene

Human Gene Mutation Database (HGMD)
THSD7A
SNPedia medical, phenotypic, and genealogical associations of SNPs for
THSD7A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for THSD7A Gene

Disorders for THSD7A Gene

MalaCards: The human disease database

(2) MalaCards diseases for THSD7A Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
membranous nephropathy
  • membranous glomerulonephritis, antenatal
osteoporosis
  • osteoporosis, postmenopausal, susceptibility
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for THSD7A

Genetic Association Database (GAD)
THSD7A
Human Genome Epidemiology (HuGE) Navigator
THSD7A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
THSD7A
genes like me logo Genes that share disorders with THSD7A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for THSD7A Gene

Publications for THSD7A Gene

  1. Soluble THSD7A is an N-glycoprotein that promotes endothelial cell migration and tube formation in angiogenesis. (PMID: 22194972) Kuo M.W. … Chuang Y.J. (PLoS ONE 2011) 3 4 64
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  3. Family-based association study for bipolar affective disorder. (PMID: 20414141) Secolin R. … Lopes-Cendes I. (Psychiatr. Genet. 2010) 3 46 64
  4. Novel association strategy with copy number variation for identifying new risk Loci of human diseases. (PMID: 20808825) Chen X. … Kong X. (PLoS ONE 2010) 3 46 64
  5. Association of genetic variations of genes encoding thrombospondin, type 1, domain-containing 4 and 7A with low bone mineral density in Japanese women with osteoporosis. (PMID: 18488137) Mori S. … Ikegawa S. (J. Hum. Genet. 2008) 3 46 64

Products for THSD7A Gene

Sources for THSD7A Gene

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