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Aliases for THSD1 Gene

Aliases for THSD1 Gene

  • Thrombospondin Type 1 Domain Containing 1 2 3 5
  • Transmembrane Molecule With Thrombospondin Module 3 4
  • TMTSP 3 4
  • Thrombospondin Type-1 Domain-Containing Protein 1 3
  • Thrombospondin, Type I, Domain Containing 1 3
  • Thrombospondin, Type I, Domain 1 2
  • 4833423O18Rik 3
  • UNQ3010 3

External Ids for THSD1 Gene

Previous GeneCards Identifiers for THSD1 Gene

  • GC13M046946
  • GC13M051887
  • GC13M050749
  • GC13M051849
  • GC13M052935
  • GC13M033689

Summaries for THSD1 Gene

Entrez Gene Summary for THSD1 Gene

  • The protein encoded by this gene contains a type 1 thrombospondin domain, which is found in a number of proteins involved in the complement pathway, as well as in extracellular matrix proteins. Alternatively spliced transcript variants encoding different isoforms have been observed for this gene. [provided by RefSeq, Jan 2009]

GeneCards Summary for THSD1 Gene

THSD1 (Thrombospondin Type 1 Domain Containing 1) is a Protein Coding gene. Among its related pathways are O-glycosylation of TSR domain-containing proteins and HIV Life Cycle.

Gene Wiki entry for THSD1 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for THSD1 Gene

Genomics for THSD1 Gene

Regulatory Elements for THSD1 Gene

Enhancers for THSD1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH13F052448 1.1 ENCODE 11.8 -43.3 -43300 3.0 CREB3L1 ARID4B SIN3A DMAP1 YY1 ZNF207 ZNF143 ZNF263 SP5 NFYC CKAP2 VPS36 TPTE2P2 THSD1
GH13F052371 1 Ensembl ENCODE 11.8 +34.4 34396 1.1 SOX13 JUN FEZF1 HIC1 ZFHX2 GLIS2 POLR2A PATZ1 PRDM10 NR2F6 CKAP2 TPTE2P2 THSD1 GC13P052401 LOC105370207
GH13F052453 1 ENCODE 10.7 -48.9 -48928 4.3 PKNOX1 ATF1 CREB3L1 WRNIP1 ARID4B SIN3A GLI4 ZNF48 ZNF121 ZNF143 CKAP2 TPTE2P2 THSD1 NEK5 GC13M052475
GH13F052427 0.7 ENCODE 12.6 -22.1 -22075 3.0 SOX13 SOX5 PKNOX1 SAP130 TEAD1 JUN TEAD3 ARID1B GATA3 ZBTB33 VPS36 TPTE2P2 THSD1 CKAP2 UTP14C ALG11 NEK5
GH13F052358 0.6 ENCODE 11.6 +46.7 46743 1.8 L3MBTL2 HNF4G FOXP2 RAD21 ATF2 YY1 CKAP2 TPTE2P2 THSD1 LOC105370207 GC13P052401
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around THSD1 on UCSC Golden Path with GeneCards custom track

Promoters for THSD1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000516486 1094 2401 ZSCAN5A KLF1 ZNF76 YY1 ZFHX2 GLIS2 POLR2A PATZ1 SCRT2 SP3

Genomic Location for THSD1 Gene

Chromosome:
13
Start:
52,377,167 bp from pter
End:
52,406,494 bp from pter
Size:
29,328 bases
Orientation:
Minus strand

Genomic View for THSD1 Gene

Genes around THSD1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
THSD1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for THSD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for THSD1 Gene

Proteins for THSD1 Gene

  • Protein details for THSD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NS62-THSD1_HUMAN
    Recommended name:
    Thrombospondin type-1 domain-containing protein 1
    Protein Accession:
    Q9NS62
    Secondary Accessions:
    • A2A3J3
    • B2RCF5
    • Q6P3U1
    • Q6UXZ2

    Protein attributes for THSD1 Gene

    Size:
    852 amino acids
    Molecular mass:
    94584 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for THSD1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for THSD1 Gene

Post-translational modifications for THSD1 Gene

  • Glycosylation at Asn 39, Asn 53, Asn 58, Asn 69, Asn 80, Asn 135, and Asn 304
  • Modification sites at PhosphoSitePlus

Other Protein References for THSD1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for THSD1

No data available for DME Specific Peptides for THSD1 Gene

Domains & Families for THSD1 Gene

Protein Domains for THSD1 Gene

Suggested Antigen Peptide Sequences for THSD1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NS62

UniProtKB/Swiss-Prot:

THSD1_HUMAN :
  • Contains 1 TSP type-1 domain.
Domain:
  • Contains 1 TSP type-1 domain.
genes like me logo Genes that share domains with THSD1: view

No data available for Gene Families for THSD1 Gene

Function for THSD1 Gene

genes like me logo Genes that share phenotypes with THSD1: view

Animal Models for THSD1 Gene

MGI Knock Outs for THSD1:

Animal Model Products

  • Taconic Biosciences Mouse Models for THSD1

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for THSD1 Gene

Localization for THSD1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for THSD1 Gene

Isoform 1: Membrane; Single-pass type I membrane protein.
Isoform 2: Membrane; Single-pass type I membrane protein.
Isoform 3: Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for THSD1 gene
Compartment Confidence
extracellular 5
cytosol 5
plasma membrane 3
mitochondrion 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for THSD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005737 cytoplasm IDA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with THSD1: view

Pathways & Interactions for THSD1 Gene

genes like me logo Genes that share pathways with THSD1: view

Interacting Proteins for THSD1 Gene

Selected Interacting proteins: Q9NS62-THSD1_HUMAN for THSD1 Gene via IID

Gene Ontology (GO) - Biological Process for THSD1 Gene

None

No data available for SIGNOR curated interactions for THSD1 Gene

Transcripts for THSD1 Gene

mRNA/cDNA for THSD1 Gene

Unigene Clusters for THSD1 Gene

Thrombospondin, type I, domain containing 1:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for THSD1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b
SP1:
SP2: - - -

Relevant External Links for THSD1 Gene

GeneLoc Exon Structure for
THSD1
ECgene alternative splicing isoforms for
THSD1

Expression for THSD1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for THSD1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for THSD1 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for THSD1 Gene



Protein tissue co-expression partners for THSD1 Gene

NURSA nuclear receptor signaling pathways regulating expression of THSD1 Gene:

THSD1

SOURCE GeneReport for Unigene cluster for THSD1 Gene:

Hs.325667
genes like me logo Genes that share expression patterns with THSD1: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for THSD1 Gene

Orthologs for THSD1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for THSD1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia THSD1 34 35
  • 98.88 (n)
dog
(Canis familiaris)
Mammalia THSD1 34 35
  • 83.26 (n)
cow
(Bos Taurus)
Mammalia THSD1 34 35
  • 81.78 (n)
mouse
(Mus musculus)
Mammalia Thsd1 34 16 35
  • 80.53 (n)
rat
(Rattus norvegicus)
Mammalia Thsd1 34
  • 79.81 (n)
oppossum
(Monodelphis domestica)
Mammalia THSD1 35
  • 72 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 62 (a)
OneToMany
-- 35
  • 43 (a)
OneToMany
chicken
(Gallus gallus)
Aves THSD1 34 35
  • 65.71 (n)
lizard
(Anolis carolinensis)
Reptilia THSD1 35
  • 49 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia thsd1 34
  • 56.13 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC797520 34
  • 49.92 (n)
THSD1 35
  • 35 (a)
OneToOne
Species where no ortholog for THSD1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for THSD1 Gene

ENSEMBL:
Gene Tree for THSD1 (if available)
TreeFam:
Gene Tree for THSD1 (if available)

Paralogs for THSD1 Gene

Pseudogenes.org Pseudogenes for THSD1 Gene

genes like me logo Genes that share paralogs with THSD1: view

No data available for Paralogs for THSD1 Gene

Variants for THSD1 Gene

Sequence variations from dbSNP and Humsavar for THSD1 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type
rs786205669 Likely pathogenic 52,397,636(-) TGGCT(A/G)TGCAC reference, missense
rs9536062 Likely pathogenic 52,397,583(+) GTCTC(C/G)CCCAA reference, missense
rs1052731 -- 52,377,282(-) TGTGT(A/G)TGCAT utr-variant-3-prime
rs1052734 -- 52,377,215(-) AATTT(C/T)TATTG utr-variant-3-prime
rs1052735 -- 52,377,209(-) TATTG(A/G)TTTAT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for THSD1 Gene

Variant ID Type Subtype PubMed ID
esv3580642 CNV loss 25503493
esv3632091 CNV loss 21293372
esv994275 CNV loss 20482838
nsv1110855 OTHER inversion 24896259
nsv428288 CNV loss 18775914
nsv7242 OTHER inversion 18451855
nsv983589 CNV duplication 23825009

Variation tolerance for THSD1 Gene

Residual Variation Intolerance Score: 9.63% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.55; 72.13% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for THSD1 Gene

Human Gene Mutation Database (HGMD)
THSD1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
THSD1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for THSD1 Gene

Disorders for THSD1 Gene

Relevant External Links for THSD1

Genetic Association Database (GAD)
THSD1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
THSD1

No disorders were found for THSD1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for THSD1 Gene

Publications for THSD1 Gene

  1. Monochromosome transfer and microarray analysis identify a critical tumor-suppressive region mapping to chromosome 13q14 and THSD1 in esophageal carcinoma. (PMID: 18403638) Ko J.M. … Lung M.L. (Mol. Cancer Res. 2008) 3 22 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. The DNA sequence and analysis of human chromosome 13. (PMID: 15057823) Dunham A. … Ross M.T. (Nature 2004) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4 64

Products for THSD1 Gene

Sources for THSD1 Gene

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