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Aliases for THSD1 Gene

Aliases for THSD1 Gene

  • Thrombospondin, Type I, Domain Containing 1 2 3
  • Transmembrane Molecule With Thrombospondin Module 3 4
  • Thrombospondin, Type I, Domain 1 2 3
  • TMTSP 3 4
  • Thrombospondin Type-1 Domain-Containing Protein 1 3
  • 4833423O18Rik 3
  • UNQ3010 3

External Ids for THSD1 Gene

Previous GeneCards Identifiers for THSD1 Gene

  • GC13M046946
  • GC13M051887
  • GC13M050749
  • GC13M051849
  • GC13M052935
  • GC13M033689

Summaries for THSD1 Gene

Entrez Gene Summary for THSD1 Gene

  • The protein encoded by this gene contains a type 1 thrombospondin domain, which is found in a number of proteins involved in the complement pathway, as well as in extracellular matrix proteins. Alternatively spliced transcript variants encoding different isoforms have been observed for this gene. [provided by RefSeq, Jan 2009]

GeneCards Summary for THSD1 Gene

THSD1 (Thrombospondin, Type I, Domain Containing 1) is a Protein Coding gene.

Gene Wiki entry for THSD1 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for THSD1 Gene

Genomics for THSD1 Gene

Regulatory Elements for THSD1 Gene

Genomic Location for THSD1 Gene

Start:
52,377,167 bp from pter
End:
52,406,494 bp from pter
Size:
29,328 bases
Orientation:
Minus strand

Genomic View for THSD1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for THSD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for THSD1 Gene

Proteins for THSD1 Gene

  • Protein details for THSD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NS62-THSD1_HUMAN
    Recommended name:
    Thrombospondin type-1 domain-containing protein 1
    Protein Accession:
    Q9NS62
    Secondary Accessions:
    • A2A3J3
    • B2RCF5
    • Q6P3U1
    • Q6UXZ2

    Protein attributes for THSD1 Gene

    Size:
    852 amino acids
    Molecular mass:
    94584 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for THSD1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for THSD1 Gene

Proteomics data for THSD1 Gene at MOPED

Post-translational modifications for THSD1 Gene

  • Glycosylation at Asn39, Asn53, Asn58, Asn69, Asn80, Asn135, and Asn304
  • Modification sites at PhosphoSitePlus

Other Protein References for THSD1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for THSD1 Gene

Domains for THSD1 Gene

Protein Domains for THSD1 Gene

Suggested Antigen Peptide Sequences for THSD1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NS62

UniProtKB/Swiss-Prot:

THSD1_HUMAN :
  • Q9NS62
Domain:
  • Contains 1 TSP type-1 domain.
genes like me logo Genes that share domains with THSD1: view

No data available for Gene Families for THSD1 Gene

Function for THSD1 Gene

Phenotypes for THSD1 Gene

MGI mutant phenotypes for THSD1:
inferred from 1 alleles
GenomeRNAi human phenotypes for THSD1:
genes like me logo Genes that share phenotypes with THSD1: view

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for THSD1 Gene

Localization for THSD1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for THSD1 Gene

Isoform 1: Membrane; Single-pass type I membrane protein.
Isoform 2: Membrane; Single-pass type I membrane protein.
Isoform 3: Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for THSD1 Gene COMPARTMENTS Subcellular localization image for THSD1 gene
Compartment Confidence
extracellular 5
cytosol 4
plasma membrane 3
endoplasmic reticulum 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for THSD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005737 cytoplasm IDA --
GO:0009986 cell surface IEA --
GO:0016021 integral component of membrane IEA --
GO:0071944 cell periphery IEA --
genes like me logo Genes that share ontologies with THSD1: view

Pathways for THSD1 Gene

SuperPathways for THSD1 Gene

No Data Available

Interacting Proteins for THSD1 Gene

Selected Interacting proteins: Q9NS62-THSD1_HUMAN for THSD1 Gene via I2D

Symbol External ID(s) Details
TLN1

Gene Ontology (GO) - Biological Process for THSD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002244 hematopoietic progenitor cell differentiation IEA --
genes like me logo Genes that share ontologies with THSD1: view

No data available for Pathways by source for THSD1 Gene

Transcripts for THSD1 Gene

mRNA/cDNA for THSD1 Gene

Unigene Clusters for THSD1 Gene

Thrombospondin, type I, domain containing 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for THSD1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b
SP1:
SP2: - - -

Relevant External Links for THSD1 Gene

GeneLoc Exon Structure for
THSD1
ECgene alternative splicing isoforms for
THSD1

Expression for THSD1 Gene

mRNA expression in normal human tissues for THSD1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for THSD1 Gene

SOURCE GeneReport for Unigene cluster for THSD1 Gene Hs.325667

genes like me logo Genes that share expressions with THSD1: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for THSD1 Gene

Orthologs for THSD1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for THSD1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia THSD1 35
  • 98.88 (n)
  • 98.46 (a)
THSD1 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia THSD1 35
  • 81.78 (n)
  • 80.91 (a)
THSD1 36
  • 80 (a)
OneToOne
dog
(Canis familiaris)
Mammalia THSD1 35
  • 83.26 (n)
  • 80.52 (a)
THSD1 36
  • 80 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Thsd1 35
  • 80.53 (n)
  • 78.73 (a)
Thsd1 16
Thsd1 36
  • 79 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia THSD1 36
  • 72 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 43 (a)
OneToMany
-- 36
  • 62 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Thsd1 35
  • 79.81 (n)
  • 78.39 (a)
chicken
(Gallus gallus)
Aves THSD1 35
  • 65.71 (n)
  • 60.22 (a)
THSD1 36
  • 58 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia THSD1 36
  • 49 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia thsd1 35
  • 56.13 (n)
  • 48.08 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC797520 35
  • 49.92 (n)
  • 39.97 (a)
THSD1 36
  • 35 (a)
OneToOne
Species with no ortholog for THSD1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for THSD1 Gene

ENSEMBL:
Gene Tree for THSD1 (if available)
TreeFam:
Gene Tree for THSD1 (if available)

Paralogs for THSD1 Gene

Pseudogenes.org Pseudogenes for THSD1 Gene

genes like me logo Genes that share paralogs with THSD1: view

No data available for Paralogs for THSD1 Gene

Variants for THSD1 Gene

Sequence variations from dbSNP and Humsavar for THSD1 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type MAF
rs1052731 -- 52,377,282(-) TGTGT(A/G)TGCAT utr-variant-3-prime
rs1052734 -- 52,377,215(-) AATTT(C/T)TATTG utr-variant-3-prime
rs1052735 -- 52,377,209(-) TATTG(A/G)TTTAT utr-variant-3-prime
rs1815669 -- 52,394,510(+) TCAGG(A/G)GGCTG intron-variant
rs3803263 -- 52,406,045(-) CTGCC(C/G/T)GTCAG utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for THSD1 Gene

Variant ID Type Subtype PubMed ID
nsv428288 CNV Loss 18775914
nsv900084 CNV Gain 21882294
nsv7242 OTHER Inversion 18451855
esv994275 CNV Loss 20482838

Relevant External Links for THSD1 Gene

HapMap Linkage Disequilibrium report
THSD1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for THSD1 Gene

Disorders for THSD1 Gene

Relevant External Links for THSD1

Genetic Association Database (GAD)
THSD1
genes like me logo Genes that share disorders with THSD1: view

No data available for UniProtKB/Swiss-Prot for THSD1 Gene

Publications for THSD1 Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The DNA sequence and analysis of human chromosome 13. (PMID: 15057823) Dunham A. … Ross M.T. (Nature 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Monochromosome transfer and microarray analysis identify a critical tumor-suppressive region mapping to chromosome 13q14 and THSD1 in esophageal carcinoma. (PMID: 18403638) Ko J.M. … Lung M.L. (Mol. Cancer Res. 2008) 3 23

Products for THSD1 Gene

Sources for THSD1 Gene

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