THSD1 Gene
protein-coding GIFtS: 50
GCID: GC13M052935
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thrombospondin, type I, domain containing 1(Previous names: thrombospondin, type I, domain 1 )
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Aliases
for THSD1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Thrombospondin, Type I, Domain Containing 11 2 | | 4833423O18Rik2 | | TMTSP1 2 3 | | UNQ30102 | | Thrombospondin, Type I, Domain 11 2 | | Thrombospondin Type-1 Domain-Containing Protein 12 | | Transmembrane Molecule With Thrombospondin Module2 3 | | |
Export aliases for THSD1 gene to outside databasesPrevious GC identifers: GC13M046946 GC13M051887 GC13M050749 GC13M051849 GC13M033689 |
Summaries
for THSD1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for THSD1:
The protein encoded by this gene contains a type 1 thrombospondin domain, which is found in a number of proteinsinvolved in the complement pathway, as well as in extracellular matrix proteins. Alternatively spliced transcriptvariants encoding different isoforms have been observed for this gene. (provided by RefSeq, Jan 2009)
Gene Wiki entry for THSD1
|
Genomic Views
for THSD1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000013.10 NC_018924.1 NT_024524.14
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the THSD1 gene promoter:
NF-AT4 NF-AT2 AP-1 POU2F1 FOXJ2 (long isoform) POU2F1a NF-AT3 FOXJ2 NF-AT1 NF-AT
Other transcription factors
Search SABiosciences Chromatin IP Primers for THSD1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat THSD1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 13q14.3 Ensembl cytogenetic band: 13q14.3 HGNC cytogenetic band: 13q14.13THSD1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 13 GeneLoc Exon Structure GeneLoc location for GC13M052935: view genomic region
(about GC identifiers)
Start:
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52,951,302 bp from pter |
End:
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52,980,629 bp from pter |
Size:
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29,328 bases |
Orientation:
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minus strand |
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Proteins
for THSD1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: THSD1_HUMAN, Q9NS62 (See
protein sequence)Recommended Name: Thrombospondin type-1 domain-containing protein 1 precursor Size: 852 amino acids; 94584 Da
Subcellular location: Isoform 1: Membrane; Single-pass type I membrane protein (Potential)
Subcellular location: Isoform 2: Membrane; Single-pass type I membrane protein (Potential)
Subcellular location: Isoform 3: Secreted
Secondary accessions: A2A3J3 B2RCF5 Q6P3U1 Q6UXZ2Alternative splicing: 3 isoforms: Q9NS62-1 Q9NS62-2 Q9NS62-3 Explore the universe of human proteins at neXtProt for THSD1: NX_Q9NS62
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9NS62
THSD1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_061146.1 NP_954872.1
ENSEMBL proteins: ENSP00000340650 ENSP00000258613 ENSP00000438512
Human Recombinant Protein Products for THSD1:
Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table
THSD1 for ontologies About GeneDecksing
THSD1 Antibody Products:
Assay Products for THSD1: |
Protein
Domains /
Families
for THSD1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
THSD1 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q9NS62ProtoNet protein and cluster: Q9NS62 1 Blocks protein family: IPB008085 Thrombospondin type 1 repeat signature
UniProtKB/Swiss-Prot: THSD1_HUMAN, Q9NS62Similarity: Contains 1 TSP type-1 domain |
Function
for THSD1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Phenotypes:
1 GenomeRNAi human phenotype for THSD1:
1 MGI mutant phenotype (inferred from 1 allele ) (MGI details for Thsd1):
THSD1 for phenotypes About GeneDecksing
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for THSD1 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for THSD1 (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): THSD1 (NM_199263) | |  | Sino Biological Human cDNA Clone for THSD1 | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for THSD1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat THSD1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for THSD1 |
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Pathways & Interactions
for THSD1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for THSD1
1 Interacting protein for THSD1 (Q9NS623) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0002244 | hematopoietic progenitor cell differentiation |
IEA | -- |
THSD1 for ontologies About GeneDecksing
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Drugs & Compounds
for THSD1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for THSD1
Search CenterWatch for drugs/clinical trials and news about THSD1
|
Transcripts
for THSD1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for THSD1 gene (2 alternative transcripts): NM_018676.3 NM_199263.2 Unigene Cluster for THSD1: Thrombospondin, type I, domain containing 1 Hs.325667 [show with all ESTs]Unigene Representative Sequence: NM_0186763 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000349258(uc001vgo.3 uc001vgp.3 uc010tgz.2) ENST00000258613
ENST00000544466
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for THSD1 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for THSD1 (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): THSD1 (NM_199263) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for THSD1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat THSD1 |
Additional cDNA sequence: AB044385.1 AK096289.1 AK298974.1 AK315087.1 AY358149.1 BC063842.1 5 DOTS entries: DT.100742202 DT.86853979 DT.99928044 DT.120790671 DT.91897683 24/314 AceView cDNA sequences (see all 314): NM_199263 BU737349 AA516386 BG982544 CR590821 BC063842 AW952895 BU074192 BM972213 BM709965 CK820208 AW592631 AA778396 AI588905 AA905651 AA844672 AI161038 T32398 CR597536 AI208829 CK818952 AI683536 CA443877 BX107214
GeneLoc Exon Structure
2 Alternative Splicing Database (ASD) splice patterns (SP) for THSD1 About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b |
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| SP1: | | | | | | | | | | | | | |
| SP2: | | | - | | - | | - | | | | | |
ECgene alternative splicing isoforms for THSD1
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Expression
for THSD1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| THSD1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGTTTGAATT
About this image
See THSD1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for THSD1
SOURCE GeneReport for Unigene cluster: Hs.325667
SABiosciences Custom PCR Arrays for THSD1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for THSD1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat THSD1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat THSD1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat THSD1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for THSD1 |
Orthologs
for THSD1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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This gene was present in the common ancestor of chordates.
Orthologs for THSD1 gene from 4/10 species (see all 10) About this table
ENSEMBL Gene Tree for THSD1 (if available)
TreeFam Gene Tree for THSD1 (if available) |
Paralogs
for THSD1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for THSD1 gene
THSD1 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for THSD1
PGOHUM00000248403
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Genomic Variants
for THSD1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 13 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for THSD1 (52951302 - 52980629 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for THSD1
1 Inversion: 37145 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing THSD1 |
|
Disorders
/ Diseases
for THSD1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
THSD1 for disorders About GeneDecksing
4  diseases for THSD1: About MalaCardsmyocardial infarction esophageal carcinoma esophagitis carcinoma
Genetic Association Database (GAD): THSD1
Export disorders for THSD1 gene to outside databases
|
Publications
for THSD1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for THSD1 gene, integrated from 9 sources (see all 13):
(articles sorted by number of sources associating them with THSD1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The DNA sequence and analysis of human chromosome 13. (PubMed id 15057823)1, 2 Dunham A.... Ross M.T. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
- Monochromosome transfer and microarray analysis identify a critical tumor-suppressive region mapping to chromosome 13q14 and THSD1 in esophageal carcinoma. (PubMed id 18403638)1, 9 Ko J.M....Lung M.L. (2008)
- Genome-wide screening for methylation-silenced genes i n colorectal cancer. (PubMed id 22664866)1 Khamas A....Sugihara K. (2012)
- Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
- Immunolocalization of thrombospondin in the human and sand rat intervertebral disc. (PubMed id 17047544)1 Gruber H.E....Hanley E.N. (2006)
- Thrombospondin induces RhoA inactivation through FAK-dependent signaling to stimulate focal adhesion disassembly. (PubMed id 15371459)1 Orr A.W....Murphy-Ullrich J.E. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
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External Searches for THSD1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing THSD1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing THSD1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing THSD1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for THSD1 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for THSD1 gene:
Search GeneIP for patents involving THSD1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for THSD1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for THSD1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for THSD1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for THSD1 | | | OriGene Protein Over-expression Lysate for THSD1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for THSD1 | | OriGene 3'-UTR Clone for THSD1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for THSD1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for THSD1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for THSD1 | | OriGene Custom Protein Services for THSD1 | | | OriGene Custom Immunoassay Development | | |
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 |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat THSD1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing THSD1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat THSD1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat THSD1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat THSD1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat THSD1 |
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 |  |  |  | |
| | | | Search Tocris compounds for THSD1 |
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 | | | THSD1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for THSD1 |
|  |  |  |  | | | | Search ThermoFisher Antibodies for THSD1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat THSD1 |
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