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Aliases for THSD1 Gene

Aliases for THSD1 Gene

  • Thrombospondin Type 1 Domain Containing 1 2 3 5
  • Transmembrane Molecule With Thrombospondin Module 3 4
  • Thrombospondin, Type I, Domain 1 2 3
  • TMTSP 3 4
  • Thrombospondin, Type I, Domain Containing 1 3
  • 4833423O18Rik 3
  • UNQ3010 3

External Ids for THSD1 Gene

Previous GeneCards Identifiers for THSD1 Gene

  • GC13M046946
  • GC13M051887
  • GC13M050749
  • GC13M051849
  • GC13M052935
  • GC13M033689

Summaries for THSD1 Gene

Entrez Gene Summary for THSD1 Gene

  • The protein encoded by this gene contains a type 1 thrombospondin domain, which is found in a number of proteins involved in the complement pathway, as well as in extracellular matrix proteins. Alternatively spliced transcript variants encoding different isoforms have been observed for this gene. [provided by RefSeq, Jan 2009]

GeneCards Summary for THSD1 Gene

THSD1 (Thrombospondin Type 1 Domain Containing 1) is a Protein Coding gene. Among its related pathways are Infectious disease and Diseases associated with O-glycosylation of proteins.

Gene Wiki entry for THSD1 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for THSD1 Gene

Genomics for THSD1 Gene

Regulatory Elements for THSD1 Gene

Enhancers for THSD1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around THSD1 on UCSC Golden Path with GeneCards custom track

Promoters for THSD1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around THSD1 on UCSC Golden Path with GeneCards custom track

Genomic Location for THSD1 Gene

52,377,167 bp from pter
52,406,494 bp from pter
29,328 bases
Minus strand

Genomic View for THSD1 Gene

Genes around THSD1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
THSD1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for THSD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for THSD1 Gene

Proteins for THSD1 Gene

  • Protein details for THSD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Thrombospondin type-1 domain-containing protein 1
    Protein Accession:
    Secondary Accessions:
    • A2A3J3
    • B2RCF5
    • Q6P3U1
    • Q6UXZ2

    Protein attributes for THSD1 Gene

    852 amino acids
    Molecular mass:
    94584 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for THSD1 Gene


neXtProt entry for THSD1 Gene

Proteomics data for THSD1 Gene at MOPED

Post-translational modifications for THSD1 Gene

  • Glycosylation at Asn 39, Asn 53, Asn 58, Asn 69, Asn 80, Asn 135, and Asn 304
  • Modification sites at PhosphoSitePlus

Other Protein References for THSD1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for THSD1 Gene

Domains & Families for THSD1 Gene

Protein Domains for THSD1 Gene

Suggested Antigen Peptide Sequences for THSD1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 TSP type-1 domain.
  • Contains 1 TSP type-1 domain.
genes like me logo Genes that share domains with THSD1: view

No data available for Gene Families for THSD1 Gene

Function for THSD1 Gene

genes like me logo Genes that share phenotypes with THSD1: view

Animal Models for THSD1 Gene

MGI Knock Outs for THSD1:

Animal Model Products

  • Taconic Biosciences Mouse Models for THSD1

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for THSD1 Gene

Localization for THSD1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for THSD1 Gene

Isoform 1: Membrane; Single-pass type I membrane protein.
Isoform 2: Membrane; Single-pass type I membrane protein.
Isoform 3: Secreted.

Subcellular locations from

Jensen Localization Image for THSD1 Gene COMPARTMENTS Subcellular localization image for THSD1 gene
Compartment Confidence
extracellular 5
cytosol 3
plasma membrane 3
endoplasmic reticulum 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for THSD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with THSD1: view

Pathways & Interactions for THSD1 Gene

genes like me logo Genes that share pathways with THSD1: view

Interacting Proteins for THSD1 Gene

Selected Interacting proteins: Q9NS62-THSD1_HUMAN for THSD1 Gene via I2D

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for THSD1 Gene


No data available for SIGNOR curated interactions for THSD1 Gene

Drugs & Compounds for THSD1 Gene

No Compound Related Data Available

Transcripts for THSD1 Gene

mRNA/cDNA for THSD1 Gene

Unigene Clusters for THSD1 Gene

Thrombospondin, type I, domain containing 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for THSD1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b
SP2: - - -

Relevant External Links for THSD1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for THSD1 Gene

mRNA expression in normal human tissues for THSD1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for THSD1 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for THSD1 Gene

SOURCE GeneReport for Unigene cluster for THSD1 Gene Hs.325667

genes like me logo Genes that share expression patterns with THSD1: view

Protein tissue co-expression partners for THSD1 Gene

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for THSD1 Gene

Orthologs for THSD1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for THSD1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia THSD1 35
  • 81.78 (n)
  • 80.91 (a)
THSD1 36
  • 80 (a)
(Canis familiaris)
Mammalia THSD1 35
  • 83.26 (n)
  • 80.52 (a)
THSD1 36
  • 80 (a)
(Mus musculus)
Mammalia Thsd1 35
  • 80.53 (n)
  • 78.73 (a)
Thsd1 16
Thsd1 36
  • 79 (a)
(Pan troglodytes)
Mammalia THSD1 35
  • 98.88 (n)
  • 98.46 (a)
THSD1 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Thsd1 35
  • 79.81 (n)
  • 78.39 (a)
(Monodelphis domestica)
Mammalia THSD1 36
  • 72 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 43 (a)
-- 36
  • 62 (a)
(Gallus gallus)
Aves THSD1 35
  • 65.71 (n)
  • 60.22 (a)
THSD1 36
  • 58 (a)
(Anolis carolinensis)
Reptilia THSD1 36
  • 49 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia thsd1 35
  • 56.13 (n)
  • 48.08 (a)
(Danio rerio)
Actinopterygii LOC797520 35
  • 49.92 (n)
  • 39.97 (a)
THSD1 36
  • 35 (a)
Species with no ortholog for THSD1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for THSD1 Gene

Gene Tree for THSD1 (if available)
Gene Tree for THSD1 (if available)

Paralogs for THSD1 Gene Pseudogenes for THSD1 Gene

genes like me logo Genes that share paralogs with THSD1: view

No data available for Paralogs for THSD1 Gene

Variants for THSD1 Gene

Sequence variations from dbSNP and Humsavar for THSD1 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type
rs13313279 - 52,397,879(+) ATTCC(A/C)CCTTC reference, missense
rs9536062 - 52,397,583(+) GTCTC(A/C/G)CCCAA reference, missense
rs9536041 - 52,377,667(+) CACTC(C/T)TGTGA reference, missense
rs56013270 - 52,378,499(+) TGTGT(C/G)CCCTG reference, missense
rs1052731 -- 52,377,282(-) TGTGT(A/G)TGCAT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for THSD1 Gene

Variant ID Type Subtype PubMed ID
nsv428288 CNV Loss 18775914
nsv900084 CNV Gain 21882294
nsv7242 OTHER Inversion 18451855
esv994275 CNV Loss 20482838

Variation tolerance for THSD1 Gene

Residual Variation Intolerance Score: 9.63% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.55; 72.13% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for THSD1 Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for THSD1 Gene

Disorders for THSD1 Gene

Relevant External Links for THSD1

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for THSD1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for THSD1 Gene

Publications for THSD1 Gene

  1. The DNA sequence and analysis of human chromosome 13. (PMID: 15057823) Dunham A. … Ross M.T. (Nature 2004) 3 4 67
  2. Monochromosome transfer and microarray analysis identify a critical tumor-suppressive region mapping to chromosome 13q14 and THSD1 in esophageal carcinoma. (PMID: 18403638) Ko J.M. … Lung M.L. (Mol. Cancer Res. 2008) 3 23
  3. Genome-wide screening for methylation-silenced genes in colorectal cancer. (PMID: 22664866) Khamas A. … Sugihara K. (Int. J. Oncol. 2012) 3
  4. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L. … Andersson-Svahn H. (Mol. Cell Proteomics 2008) 3
  5. Immunolocalization of thrombospondin in the human and sand rat intervertebral disc. (PMID: 17047544) Gruber H.E. … Hanley E.N. (Spine 2006) 3

Products for THSD1 Gene

Sources for THSD1 Gene