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Aliases for THRSP Gene

Aliases for THRSP Gene

  • Thyroid Hormone Responsive 2 3
  • Lipogenic Protein 1 2 3
  • Spot 14 Protein 3 4
  • SPOT14 3 4
  • S14 3 4
  • Thyroid Hormone Responsive (SPOT14 Homolog, Rat) 3
  • Thyroid Hormone Responsive SPOT14 (Rat) Homolog 2
  • Thyroid Hormone Responsive SPOT14 3
  • SPOT14 Homolog (Rat) 2
  • SPOT14 Homolog 3
  • LPGP1 3
  • Lpgp 3
  • THRP 3

External Ids for THRSP Gene

Previous HGNC Symbols for THRSP Gene

  • LPGP1

Previous GeneCards Identifiers for THRSP Gene

  • GC11P080101
  • GC11M079313
  • GC11P077997
  • GC11P077501
  • GC11P077452
  • GC11P077776
  • GC11P074076

Summaries for THRSP Gene

Entrez Gene Summary for THRSP Gene

  • The protein encoded by this gene is similar to the gene product of S14, a rat gene whose expression is limited to liver and adipose tissue and is controlled by nutritional and hormonal factors. This gene has been shown to be expressed in liver and adipocytes, particularly in lipomatous modules. It is also found to be expressed in lipogenic breast cancers, which suggests a role in controlling tumor lipid metabolism. [provided by RefSeq, Jul 2008]

GeneCards Summary for THRSP Gene

THRSP (Thyroid Hormone Responsive) is a Protein Coding gene. GO annotations related to this gene include protein homodimerization activity. An important paralog of this gene is MID1IP1.

UniProtKB/Swiss-Prot for THRSP Gene

  • Plays a role in the regulation of lipogenesis, especially in lactating mammary gland. Important for the biosynthesis of triglycerides with medium-length fatty acid chains. May modulate lipogenesis by interacting with MID1IP1 and preventing its interaction with ACACA (By similarity). May function as transcriptional coactivator. May modulate the transcription factor activity of THRB.

Gene Wiki entry for THRSP Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for THRSP Gene

Genomics for THRSP Gene

Regulatory Elements for THRSP Gene

Genomic Location for THRSP Gene

Chromosome:
11
Start:
78,063,861 bp from pter
End:
78,068,357 bp from pter
Size:
4,497 bases
Orientation:
Plus strand

Genomic View for THRSP Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for THRSP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for THRSP Gene

Proteins for THRSP Gene

  • Protein details for THRSP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92748-THRSP_HUMAN
    Recommended name:
    Thyroid hormone-inducible hepatic protein
    Protein Accession:
    Q92748
    Secondary Accessions:
    • B2R4W7

    Protein attributes for THRSP Gene

    Size:
    146 amino acids
    Molecular mass:
    16561 Da
    Quaternary structure:
    • Homodimer. Heterodimer with MID1IP1 (By similarity). Interacts with THRB and PLAGL1.

neXtProt entry for THRSP Gene

Proteomics data for THRSP Gene at MOPED

Post-translational modifications for THRSP Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for THRSP Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for THRSP Gene

Domains & Families for THRSP Gene

Protein Domains for THRSP Gene

Suggested Antigen Peptide Sequences for THRSP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q92748

UniProtKB/Swiss-Prot:

THRSP_HUMAN :
  • Belongs to the SPOT14 family.
Family:
  • Belongs to the SPOT14 family.
genes like me logo Genes that share domains with THRSP: view

No data available for Gene Families for THRSP Gene

Function for THRSP Gene

Molecular function for THRSP Gene

GENATLAS Biochemistry:
thyroid hormone responsive spot 14,17kDa,rat homog,involved in lipogenesis in liver,mammary and adipose tissues,amplified in breast tumors with poor prognosis
UniProtKB/Swiss-Prot Function:
Plays a role in the regulation of lipogenesis, especially in lactating mammary gland. Important for the biosynthesis of triglycerides with medium-length fatty acid chains. May modulate lipogenesis by interacting with MID1IP1 and preventing its interaction with ACACA (By similarity). May function as transcriptional coactivator. May modulate the transcription factor activity of THRB.

Gene Ontology (GO) - Molecular Function for THRSP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0042803 protein homodimerization activity IEA --
genes like me logo Genes that share ontologies with THRSP: view
genes like me logo Genes that share phenotypes with THRSP: view

Animal Models for THRSP Gene

MGI Knock Outs for THRSP:

Animal Model Products

miRNA for THRSP Gene

miRTarBase miRNAs that target THRSP

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for THRSP Gene

Localization for THRSP Gene

Subcellular locations from UniProtKB/Swiss-Prot for THRSP Gene

Nucleus. Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for THRSP Gene COMPARTMENTS Subcellular localization image for THRSP gene
Compartment Confidence
cytosol 4
nucleus 4
mitochondrion 1

Gene Ontology (GO) - Cellular Components for THRSP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005829 cytosol ISS --
genes like me logo Genes that share ontologies with THRSP: view

Pathways & Interactions for THRSP Gene

SuperPathways for THRSP Gene

No Data Available

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Interacting Proteins for THRSP Gene

Gene Ontology (GO) - Biological Process for THRSP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006629 lipid metabolic process IEA --
GO:0010866 regulation of triglyceride biosynthetic process IEA --
GO:0046890 regulation of lipid biosynthetic process ISS --
genes like me logo Genes that share ontologies with THRSP: view

No data available for Pathways by source and SIGNOR curated interactions for THRSP Gene

Drugs & Compounds for THRSP Gene

(3) Drugs for THRSP Gene - From: NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Levothyroxine Approved Pharma 0
triiodothyronine Pharma 0
pyruvate Nutra 27

(5) Additional Compounds for THRSP Gene - From: NovoSeek

genes like me logo Genes that share compounds with THRSP: view

Transcripts for THRSP Gene

mRNA/cDNA for THRSP Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(60) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for THRSP Gene

Thyroid hormone responsive:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for THRSP

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for THRSP Gene

No ASD Table

Relevant External Links for THRSP Gene

GeneLoc Exon Structure for
THRSP
ECgene alternative splicing isoforms for
THRSP

Expression for THRSP Gene

mRNA expression in normal human tissues for THRSP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for THRSP Gene

This gene is overexpressed in Adipose - Visceral (Omentum) (x12.2), Liver (x11.7), Adipose - Subcutaneous (x10.8), and Breast - Mammary Tissue (x8.7).

SOURCE GeneReport for Unigene cluster for THRSP Gene Hs.591969

mRNA Expression by UniProt/SwissProt for THRSP Gene

Q92748-THRSP_HUMAN
Tissue specificity: Mainly expressed in tissues that synthesize triglycerides
genes like me logo Genes that share expression patterns with THRSP: view

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for THRSP Gene

Orthologs for THRSP Gene

This gene was present in the common ancestor of chordates.

Orthologs for THRSP Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia THRSP 35
  • 82.64 (n)
  • 75.69 (a)
THRSP 36
  • 71 (a)
OneToOne
dog
(Canis familiaris)
Mammalia THRSP 35
  • 78.24 (n)
  • 70.14 (a)
THRSP 36
  • 70 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Thrsp 35
  • 84.37 (n)
  • 85.52 (a)
Thrsp 16
Thrsp 36
  • 80 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia THRSP 35
  • 99.77 (n)
  • 99.32 (a)
THRSP 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Thrsp 35
  • 83.68 (n)
  • 83.45 (a)
oppossum
(Monodelphis domestica)
Mammalia THRSP 36
  • 66 (a)
OneToOne
chicken
(Gallus gallus)
Aves THRSP 36
  • 29 (a)
OneToMany
THRSP 36
  • 27 (a)
OneToMany
THRSPB 36
  • 29 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 36 (a)
OneToMany
-- 36
  • 40 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii THRSP 36
  • 34 (a)
OneToOne
Species with no ortholog for THRSP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for THRSP Gene

ENSEMBL:
Gene Tree for THRSP (if available)
TreeFam:
Gene Tree for THRSP (if available)

Paralogs for THRSP Gene

Paralogs for THRSP Gene

(1) SIMAP similar genes for THRSP Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with THRSP: view

Variants for THRSP Gene

Structural Variations from Database of Genomic Variants (DGV) for THRSP Gene

Variant ID Type Subtype PubMed ID
nsv520740 CNV Gain 19592680

Variation tolerance for THRSP Gene

Residual Variation Intolerance Score: 63.43% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.08; 38.06% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for THRSP Gene

HapMap Linkage Disequilibrium report
THRSP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for THRSP Gene

Disorders for THRSP Gene

Relevant External Links for THRSP

Genetic Association Database (GAD)
THRSP
Human Genome Epidemiology (HuGE) Navigator
THRSP
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
THRSP
genes like me logo Genes that share disorders with THRSP: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for THRSP Gene

Publications for THRSP Gene

  1. Hepatic expression of thyroid hormone-responsive spot 14 protein is regulated by constitutive androstane receptor (NR1I3). (PMID: 20185760) Breuker C. … Pascussi J.M. (Endocrinology 2010) 23 67
  2. Thyroid hormone responsive Spot 14 increases during differentiation of human adipocytes and its expression is down-regulated in obese subjects. (PMID: 20029374) Ortega F.J. … FernA!ndez-Real J.M. (Int J Obes (Lond) 2010) 23 67
  3. Conjugated linoleic acid (CLA) inhibits expression of the Spot 14 (THRSP) and fatty acid synthase genes and impairs the growth of human breast cancer and liposarcoma cells. (PMID: 19116881) Donnelly C. … Kinlaw W.B. (Nutr Cancer 2009) 23 67
  4. Subcutaneous fat shows higher thyroid hormone receptor-alpha1 gene expression than omental fat. (PMID: 19360007) Ortega F.J. … FernA!ndez-Real J.M. (Obesity (Silver Spring) 2009) 23 67
  5. A novel pregnane X receptor and S14-mediated lipogenic pathway in human hepatocyte. (PMID: 19437491) Moreau A. … Pascussi J.M. (Hepatology 2009) 23 67

Products for THRSP Gene

Sources for THRSP Gene

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