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Aliases for THRSP Gene

Aliases for THRSP Gene

  • Thyroid Hormone Responsive 2 3 5
  • Lipogenic Protein 1 2 3
  • Spot 14 Protein 3 4
  • SPOT14 3 4
  • S14 3 4
  • Thyroid Hormone Responsive (SPOT14 Homolog, Rat) 3
  • Thyroid Hormone Responsive SPOT14 (Rat) Homolog 2
  • Thyroid Hormone-Inducible Hepatic Protein 3
  • Thyroid Hormone Responsive SPOT14 3
  • SPOT14 Homolog (Rat) 2
  • SPOT14 Homolog 3
  • LPGP1 3
  • Lpgp 3
  • THRP 3

External Ids for THRSP Gene

Previous HGNC Symbols for THRSP Gene

  • LPGP1

Previous GeneCards Identifiers for THRSP Gene

  • GC11P080101
  • GC11M079313
  • GC11P077997
  • GC11P077501
  • GC11P077452
  • GC11P077776
  • GC11P074076

Summaries for THRSP Gene

Entrez Gene Summary for THRSP Gene

  • The protein encoded by this gene is similar to the gene product of S14, a rat gene whose expression is limited to liver and adipose tissue and is controlled by nutritional and hormonal factors. This gene has been shown to be expressed in liver and adipocytes, particularly in lipomatous modules. It is also found to be expressed in lipogenic breast cancers, which suggests a role in controlling tumor lipid metabolism. [provided by RefSeq, Jul 2008]

GeneCards Summary for THRSP Gene

THRSP (Thyroid Hormone Responsive) is a Protein Coding gene. Among its related pathways are Metabolism and Import of palmitoyl-CoA into the mitochondrial matrix. GO annotations related to this gene include protein homodimerization activity. An important paralog of this gene is MID1IP1.

UniProtKB/Swiss-Prot for THRSP Gene

  • Plays a role in the regulation of lipogenesis, especially in lactating mammary gland. Important for the biosynthesis of triglycerides with medium-length fatty acid chains. May modulate lipogenesis by interacting with MID1IP1 and preventing its interaction with ACACA (By similarity). May function as transcriptional coactivator. May modulate the transcription factor activity of THRB.

Gene Wiki entry for THRSP Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for THRSP Gene

Genomics for THRSP Gene

Regulatory Elements for THRSP Gene

Enhancers for THRSP Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11F078082 0.8 ENCODE 11 +21.4 21425 4.6 ELF3 MLX ARID4B ZNF48 RAD21 DNMT3B RARA GATA4 CREM MIXL1 KCTD21-AS1 THRSP KCTD14 ENSG00000254829 INTS4 NDUFC2 ALG8 AAMDC LOC105369401 GC11P078094
GH11F078027 0.7 ENCODE 10.9 -35.7 -35651 2.2 SOX13 PKNOX1 SAP130 JUN ZNF384 TEAD3 ZNF664 GATA3 POLR3A FOSL2 KCTD21-AS1 INTS4 THRSP ENSG00000254675 KCTD14
GH11F078090 0.8 ENCODE 10.9 +27.0 27021 1.6 ELF3 TBP MLX ARID4B DMAP1 ZSCAN9 RAD21 RARA YY1 SLC30A9 KCTD21-AS1 KCTD14 THRSP ENSG00000254829 INTS4 NDUFC2 KCTD21 GC11P078094 LOC105369401
GH11F078019 0.6 Ensembl ENCODE 10.9 -43.8 -43824 0.3 CBX3 INSM2 ZNF707 JUND BCL6 KDM1A FOS SP7 INTS4 KCTD14 THRSP NDUFC2 KCTD21-AS1 ENSG00000254675 ENSG00000254829
GH11F078029 1.2 Ensembl ENCODE 10.9 -32.7 -32712 2.3 SOX13 PKNOX1 MAX FEZF1 EBF1 ZNF644 ZKSCAN1 ZNF121 ZBTB48 PATZ1 KCTD21-AS1 INTS4 THRSP KCTD21 KCTD14 ENSG00000254675
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around THRSP on UCSC Golden Path with GeneCards custom track

Genomic Location for THRSP Gene

Chromosome:
11
Start:
78,063,861 bp from pter
End:
78,068,357 bp from pter
Size:
4,497 bases
Orientation:
Plus strand

Genomic View for THRSP Gene

Genes around THRSP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
THRSP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for THRSP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for THRSP Gene

Proteins for THRSP Gene

  • Protein details for THRSP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92748-THRSP_HUMAN
    Recommended name:
    Thyroid hormone-inducible hepatic protein
    Protein Accession:
    Q92748
    Secondary Accessions:
    • B2R4W7

    Protein attributes for THRSP Gene

    Size:
    146 amino acids
    Molecular mass:
    16561 Da
    Quaternary structure:
    • Homodimer. Heterodimer with MID1IP1 (By similarity). Interacts with THRB and PLAGL1.

neXtProt entry for THRSP Gene

Post-translational modifications for THRSP Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for THRSP Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for THRSP Gene

Domains & Families for THRSP Gene

Protein Domains for THRSP Gene

Suggested Antigen Peptide Sequences for THRSP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q92748

UniProtKB/Swiss-Prot:

THRSP_HUMAN :
  • Belongs to the SPOT14 family.
Family:
  • Belongs to the SPOT14 family.
genes like me logo Genes that share domains with THRSP: view

No data available for Gene Families for THRSP Gene

Function for THRSP Gene

Molecular function for THRSP Gene

GENATLAS Biochemistry:
thyroid hormone responsive spot 14,17kDa,rat homog,involved in lipogenesis in liver,mammary and adipose tissues,amplified in breast tumors with poor prognosis
UniProtKB/Swiss-Prot Function:
Plays a role in the regulation of lipogenesis, especially in lactating mammary gland. Important for the biosynthesis of triglycerides with medium-length fatty acid chains. May modulate lipogenesis by interacting with MID1IP1 and preventing its interaction with ACACA (By similarity). May function as transcriptional coactivator. May modulate the transcription factor activity of THRB.

Gene Ontology (GO) - Molecular Function for THRSP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042802 identical protein binding IPI 25416956
GO:0042803 protein homodimerization activity IEA --
genes like me logo Genes that share ontologies with THRSP: view
genes like me logo Genes that share phenotypes with THRSP: view

Animal Models for THRSP Gene

MGI Knock Outs for THRSP:

Animal Model Products

miRNA for THRSP Gene

miRTarBase miRNAs that target THRSP

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for THRSP Gene

Localization for THRSP Gene

Subcellular locations from UniProtKB/Swiss-Prot for THRSP Gene

Nucleus. Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for THRSP Gene COMPARTMENTS Subcellular localization image for THRSP gene
Compartment Confidence
cytosol 5
nucleus 5
mitochondrion 3
golgi apparatus 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for THRSP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IEA,ISS --
genes like me logo Genes that share ontologies with THRSP: view

Pathways & Interactions for THRSP Gene

genes like me logo Genes that share pathways with THRSP: view

Interacting Proteins for THRSP Gene

Gene Ontology (GO) - Biological Process for THRSP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006629 lipid metabolic process IEA,TAS --
GO:0010866 regulation of triglyceride biosynthetic process IEA --
GO:0046890 regulation of lipid biosynthetic process IEA,ISS --
genes like me logo Genes that share ontologies with THRSP: view

No data available for SIGNOR curated interactions for THRSP Gene

Drugs & Compounds for THRSP Gene

(4) Drugs for THRSP Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(4) Additional Compounds for THRSP Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with THRSP: view

Transcripts for THRSP Gene

mRNA/cDNA for THRSP Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(60) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for THRSP Gene

Thyroid hormone responsive:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for THRSP Gene

No ASD Table

Relevant External Links for THRSP Gene

GeneLoc Exon Structure for
THRSP
ECgene alternative splicing isoforms for
THRSP

Expression for THRSP Gene

mRNA expression in normal human tissues for THRSP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for THRSP Gene

This gene is overexpressed in Adipose - Visceral (Omentum) (x12.2), Liver (x11.7), Adipose - Subcutaneous (x10.8), and Breast - Mammary Tissue (x8.7).

NURSA nuclear receptor signaling pathways regulating expression of THRSP Gene:

THRSP

SOURCE GeneReport for Unigene cluster for THRSP Gene:

Hs.591969

mRNA Expression by UniProt/SwissProt for THRSP Gene:

Q92748-THRSP_HUMAN
Tissue specificity: Mainly expressed in tissues that synthesize triglycerides.
genes like me logo Genes that share expression patterns with THRSP: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for THRSP Gene

Orthologs for THRSP Gene

This gene was present in the common ancestor of chordates.

Orthologs for THRSP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia THRSP 34 35
  • 99.77 (n)
mouse
(Mus musculus)
Mammalia Thrsp 34 16 35
  • 84.37 (n)
rat
(Rattus norvegicus)
Mammalia Thrsp 34
  • 83.68 (n)
cow
(Bos Taurus)
Mammalia THRSP 34 35
  • 82.64 (n)
dog
(Canis familiaris)
Mammalia THRSP 34 35
  • 78.24 (n)
oppossum
(Monodelphis domestica)
Mammalia THRSP 35
  • 66 (a)
OneToOne
chicken
(Gallus gallus)
Aves THRSP 35 35
  • 29 (a)
OneToMany
THRSPB 35
  • 29 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 40 (a)
OneToMany
-- 35
  • 36 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii THRSP 35
  • 34 (a)
OneToOne
Species where no ortholog for THRSP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for THRSP Gene

ENSEMBL:
Gene Tree for THRSP (if available)
TreeFam:
Gene Tree for THRSP (if available)

Paralogs for THRSP Gene

Paralogs for THRSP Gene

(1) SIMAP similar genes for THRSP Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with THRSP: view

Variants for THRSP Gene

Sequence variations from dbSNP and Humsavar for THRSP Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs10536825 -- 78,068,777(+) AGACT(-/GTC)GTCTC intron-variant, downstream-variant-500B, cds-indel
rs10793281 -- 78,066,775(+) AGCAA(C/G)AGTTA intron-variant
rs10899435 -- 78,065,973(+) GATGG(A/G)GCTGT intron-variant
rs111314711 -- 78,067,404(+) GGCGT(C/G)AGCCA intron-variant
rs111453241 -- 78,062,111(+) CCCAC(A/G)TCCCC intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for THRSP Gene

Variant ID Type Subtype PubMed ID
nsv1050891 CNV gain 25217958
nsv520740 CNV gain 19592680

Variation tolerance for THRSP Gene

Residual Variation Intolerance Score: 63.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.08; 38.06% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for THRSP Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
THRSP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for THRSP Gene

Disorders for THRSP Gene

Relevant External Links for THRSP

Genetic Association Database (GAD)
THRSP
Human Genome Epidemiology (HuGE) Navigator
THRSP
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
THRSP

No disorders were found for THRSP Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for THRSP Gene

Publications for THRSP Gene

  1. Human spot 14 protein interacts physically and functionally with the thyroid receptor. (PMID: 17418816) Chou W.Y. … Huang S.M. (Biochem. Biophys. Res. Commun. 2007) 3 4 22 64
  2. Cloning and initial characterization of human and mouse Spot 14 genes. (PMID: 9003802) Grillasca J.-P. … Planells R. (FEBS Lett. 1997) 2 3 4 64
  3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 64
  4. Human Spot 14 protein is a p53-dependent transcriptional coactivator via the recruitment of thyroid receptor and Zac1. (PMID: 18299245) Chou W.Y. … Huang S.M. (Int. J. Biochem. Cell Biol. 2008) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for THRSP Gene

Sources for THRSP Gene

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