Aliases for THRSP Gene
External Ids for THRSP Gene
Previous HGNC Symbols for THRSP Gene
Previous GeneCards Identifiers for THRSP Gene
The protein encoded by this gene is similar to the gene product of S14, a rat gene whose expression is limited to liver and adipose tissue and is controlled by nutritional and hormonal factors. This gene has been shown to be expressed in liver and adipocytes, particularly in lipomatous modules. It is also found to be expressed in lipogenic breast cancers, which suggests a role in controlling tumor lipid metabolism. [provided by RefSeq, Jul 2008]
GeneCards Summary for THRSP Gene
THRSP (Thyroid Hormone Responsive) is a Protein Coding gene. Diseases associated with THRSP include Retinitis Pigmentosa 51. Among its related pathways are Metabolism and Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha). GO annotations related to this gene include protein homodimerization activity. An important paralog of this gene is MID1IP1.
UniProtKB/Swiss-Prot for THRSP Gene
Plays a role in the regulation of lipogenesis, especially in lactating mammary gland. Important for the biosynthesis of triglycerides with medium-length fatty acid chains. May modulate lipogenesis by interacting with MID1IP1 and preventing its interaction with ACACA (By similarity). May function as transcriptional coactivator. May modulate the transcription factor activity of THRB.