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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

THRSP Gene

protein-coding   GIFtS: 52
GCID: GC11P077776

thyroid hormone responsive

(Previous names: thyroid hormone responsive SPOT14 (rat) homolog, lipogenic...)
(Previous symbol: LPGP1)
 Explore 10 diseases affiliated with
THRSP via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for THRSP    

Aliases
for THRSP gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Thyroid Hormone Responsive1 2     Spot 14 Protein2 3
S141 2 3     Thyroid Hormone Responsive SPOT14 (Rat) Homolog1
SPOT141 2 3     SPOT14 Homolog2
LPGP11 2     Thyroid Hormone Responsive (SPOT14 Homolog, Rat)2
Lpgp1 2     Thyroid Hormone Responsive SPOT142
THRP1 2     Thyroid Hormone-Inducible Hepatic Protein2
Lipogenic Protein 11 2     

External Ids:    HGNC: 118001   Entrez Gene: 70692   Ensembl: ENSG000001513657   OMIM: 6019265   UniProtKB: Q927483   

Export aliases for THRSP gene to outside databases

Previous GC identifers: GC11P080101 GC11M079313 GC11P077997 GC11P077501 GC11P077452 GC11P074076


Summaries
for THRSP gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for THRSP:
The protein encoded by this gene is similar to the gene product of S14, a rat gene whose expression is limited to liver
and adipose tissue and is controlled by nutritional and hormonal factors. This gene has been shown to be expressed in
liver and adipocytes, particularly in lipomatous modules. It is also found to be expressed in lipogenic breast
cancers, which suggests a role in controlling tumor lipid metabolism. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: THRSP_HUMAN, Q92748
Function: Plays a role in the regulation of lipogenesis, especially in lactating mammary gland. Important for the
biosynthesis of triglycerides with medium-length fatty acid chains. May modulate lipogenesis by interacting with
MID1IP1 and preventing its interaction with ACACA (By similarity). May function as transcriptional coactivator. May
modulate the transcription factor activity of THRB

Gene Wiki entry for THRSP


Genomic Views
for THRSP gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.1  NT_167190.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the THRSP gene promoter:
         NF-1/L   NF-1   AP-1   ATF-2   E47   PPAR-gamma1   PPAR-gamma2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: THRSP promoter sequence
   Search SABiosciences Chromatin IP Primers for THRSP

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat THRSP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q14.1   Ensembl cytogenetic band:  11q14.1   HGNC cytogenetic band: 11q14.1

THRSP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
THRSP gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P077776:  view genomic region     (about GC identifiers)

Start:
 77,774,907 bp from pter      End:
 77,779,397 bp from pter
Size:
 4,491 bases      Orientation:
 plus strand

Proteins
for THRSP gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: THRSP_HUMAN, Q92748 (See protein sequence)
Recommended Name: Thyroid hormone-inducible hepatic protein  
Size: 146 amino acids; 16561 Da
Subunit: Homodimer. Heterodimer with MID1IP1 (By similarity). Interacts with THRB and PLAGL1
Subcellular location: Nucleus. Cytoplasm
Secondary accessions: B2R4W7

Explore the universe of human proteins at neXtProt for THRSP: NX_Q92748

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q92748

    • THRSP Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_003242.1  
    ENSEMBL proteins: 
     ENSP00000281030  

    Human Recombinant Protein Products: 
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    OriGene Protein Over-expression Lysate: THRSP
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    Novus Biologicals THRSP Proteins
    Novus Biologicals THRSP Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for THRSP

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005829cytosol ISS--


    THRSP for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for THRSP

    Protein Domains /
    Families
    for THRSP gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    THRSP for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR009786 Spot_14

    Graphical View of Domain Structure for InterPro Entry Q92748

    ProtoNet protein and cluster: Q92748

    1 Blocks protein family: IPB009786 Thyroid hormone-inducible hepatic Spot 14

    UniProtKB/Swiss-Prot: THRSP_HUMAN, Q92748
    Similarity: Belongs to the SPOT14 family


    Function
    for THRSP gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: THRSP_HUMAN, Q92748
    Function: Plays a role in the regulation of lipogenesis, especially in lactating mammary gland. Important for the
    biosynthesis of triglycerides with medium-length fatty acid chains. May modulate lipogenesis by interacting with
    MID1IP1 and preventing its interaction with ACACA (By similarity). May function as transcriptional coactivator. May
    modulate the transcription factor activity of THRB

         Genatlas biochemistry entry for THRSP:
    thyroid hormone responsive spot 14,17kDa,rat homog,involved in lipogenesis in liver,mammary and adipose
    tissues,amplified in breast tumors with poor prognosis

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat THRSP
    8/12 QIAGEN miScript miRNA Assays for microRNAs that regulate THRSP (see all 12):
    hsa-miR-98 hsa-miR-1294 hsa-let-7d hsa-let-7c hsa-let-7i hsa-let-7e hsa-let-7g hsa-miR-141*
    SwitchGear 3'UTR luciferase reporter plasmid: THRSP 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for THRSP (see all 7)
    OriGene shRNA RFP: THRSP
    OriGene siRNA: THRSP
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat THRSP

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for THRSP

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for THRSP (see all 3)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat THRSP 

    Cell Line
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    In Situ Assay
    Products:       
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    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0042803protein homodimerization activity IEA--


    THRSP for ontologies           About GeneDecksing


    3 GenomeRNAi human phenotypes for THRSP:
     Decreased influenza A virus in  Increased gamma-H2AX phosphory  Synthetic lethal with Ras 

    Animal Models:
         Mouse knock-out Thrsptm1Cnm for THRSP
         3 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Thrsp):
     endocrine/exocrine gland  homeostasis/metabolism  integument 

    THRSP for phenotypes           About GeneDecksing


    Pathways & Interactions
    for THRSP gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for THRSP

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for THRSP (ENSP000002810304) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MID1IP1ENSP000003387064STRING: ENSP00000338706
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IEA--
    GO:0006629lipid metabolic process IEA--
    GO:0008610lipid biosynthetic process ----
    GO:0010866regulation of triglyceride biosynthetic process IEA--


    THRSP for ontologies           About GeneDecksing



    Drugs & Compounds
    for THRSP gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    THRSP for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for THRSP
    8 Novoseek chemical compound relationships for THRSP gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    fatty acid 52.4 19 19116881 (3), 12917410 (2), 10551830 (2), 1734874 (2) (see all 10)
    thyroxine 46.6 2 18647617 (1)
    triiodothyronine 40.4 6 9027365 (3), 12855010 (2)
    sterol 40.1 2 12917410 (1), 16300755 (1)
    glucose 27.1 15 8895333 (5), 11485565 (2), 8869748 (1), 12855010 (1) (see all 7)
    lipid 25.4 2 9027365 (1), 16809441 (1)
    pyruvate 16.9 2 11485565 (1), 9240934 (1)
    steroid 0 2 16552628 (2)

    Search CenterWatch for drugs/clinical trials and news about THRSP 

    Transcripts
    for THRSP gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for THRSP gene: 
    NM_003251.3  

    Unigene Cluster for THRSP:

    Thyroid hormone responsive
    Hs.591969  [show with all ESTs]
    Unigene Representative Sequence: BC031989
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000281030(uc001oyx.3)

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat THRSP
    8/12 QIAGEN miScript miRNA Assays for microRNAs that regulate THRSP (see all 12):
    hsa-miR-98 hsa-miR-1294 hsa-let-7d hsa-let-7c hsa-let-7i hsa-let-7e hsa-let-7g hsa-miR-141*
    SwitchGear 3'UTR luciferase reporter plasmid: THRSP 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for THRSP (see all 7)
    OriGene shRNA RFP: THRSP
    OriGene siRNA: THRSP
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat THRSP
    Clone
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat THRSP
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat THRSP

    Additional cDNA sequence: 

    AK311975.1 BC031989.1 

    4 DOTS entries:

    DT.100703008  DT.428135  DT.100779702  DT.95171696 

    24/60 AceView cDNA sequences (see all 60):

    BG741880 BG696418 CB163960 BG675284 AI654817 BG675356 BG698070 CB137802 
    NM_003251 AI215778 CB139123 AI631972 CB268329 BG740485 BG743363 BG742057 
    AI480357 CA407233 BG741308 BG743579 AI927972 BP382021 BC031989 BG742786 

    GeneLoc Exon Structure


    Expression
    for THRSP gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    THRSP expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TGAGGGCTAT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    THRSP expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    7 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    EyeInner Nuclear LayerAII Amacrine CellsAmacrine, Retina
    EyeInner Nuclear LayerGABAergic Amacrine CellsAmacrine, Retina
    EyeInner Nuclear LayerMature Horizontal CellsHorizontal, Retina
    TestisSeminiferous TubulesSertoli cellsTestis
    AdiposeBody Subcutaneous White AdiposeAdipose
    AdiposeVisceral White AdiposeAdipose
    BrainHypothalamusBrain
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See THRSP Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for THRSP

    SOURCE GeneReport for Unigene cluster: Hs.591969

    UniProtKB/Swiss-Prot: THRSP_HUMAN, Q92748
    Tissue specificity: Mainly expressed in tissues that synthesize triglycerides

        SABiosciences Expression via Pathway-Focused PCR Array including THRSP: 
              Hepatotoxicity in human mouse rat

    Primer
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    In Situ
    Assay Products:     
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    Orthologs
    for THRSP gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for THRSP gene from 3/9 species (see all 9)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves THRSP6
    		 thyroid hormone responsive spot 14 alpha
    		 26(a)
    		 1 ↔ 1
    		 1(197836616-197838040)
    lizard
    (Anolis carolinensis)    		 Reptilia --
    --
    		 --
    		 41(a)
    36(a)
    		 1 ↔ many
    1 ↔ many
    		 GL343337.1(573573-573953)
    GL343337.1(552528-552941)
    zebrafish
    (Danio rerio)    		 Actinopterygii zgc:1936166
    		 zgc:193616
    		 34(a)
    		 1 ↔ 1
    		 15(9582648-9583121)


    ENSEMBL Gene Tree for THRSP (if available)
    TreeFam Gene Tree for THRSP (if available) 

    Paralogs
    for THRSP gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for THRSP gene
    MID1IP12  
    1 SIMAP similar gene for THRSP using alignment to 1 protein entry:     THRSP_HUMAN:
    MID1IP1

    THRSP for paralogs           About GeneDecksing



    Genomic Variants
    for THRSP gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/127 NCBI SNPs in THRSP are shown (see all 127)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 11 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1479023521,2
    		--77772915(+) GGGTTC/TAAATG 4 -- us2k1 int10--------
    rs6775871,2
    		C,F,A,H,--77772960(+) TACAGG/ACATGA 4 -- int1 us2k18Minor allele frequency- A:0.23NA CSA EA 254
    rs1163861091,2
    		C,F,--77772988(+) GGAGGC/TGGAAT 4 -- us2k1 int11Minor allele frequency- T:0.15WA 118
    rs1401102901,2
    		--77773070(+) GTCAGC/TTGGGA 4 -- int1 us2k10--------
    rs1831560081,2
    		--77773148(+) CTGTTC/GAGCCC 4 -- int1 us2k10--------
    rs1114532411,2
    		--77773157(+) CCCACG/ATCCCC 4 -- us2k1 int12Minor allele frequency- A:0.07CSA WA 120
    rs1180018371,2
    		--77773196(+) TCCTGC/TAGGCG 4 -- us2k1 int11Minor allele frequency- T:0.01NA 120
    rs5907951,2
    		C,A,H,--77773419(-) GCTGCG/ACCACT 4 -- int1 us2k111Minor allele frequency- A:0.19NA WA CSA EA 259
    rs4969311,2
    		C,F,A,H,--77773433(+) ATCTCG/AGCTCA 4 -- int1 us2k18Minor allele frequency- A:0.24NA CSA EA 254
    rs357897721,2
    		C,--77773473(+) ATTCTA/CCTGCC 4 -- us2k1 int10--------

    HapMap Linkage Disequilibrium report for THRSP (77774907 - 77779397 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for THRSP: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing THRSP
    DNA2.0 Custom Variant and Variant Library Synthesis for THRSP

    Disorders / Diseases
    for THRSP gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    THRSP for disorders           About GeneDecksing

    OMIM gene information: 601926    OMIM disorders: --

    10 diseases for THRSP:    About MalaCards
    allan-herndon-dudley syndrome    thyroiditis    breast cancer    euthyroid sick syndrome
    hepatitis    intrahepatic cholangiocarcinoma    liposarcoma    cholangiocarcinoma
    obesity    cerebritis

    1 disease from the University of Copenhagen DISEASES database for THRSP:
    Hypothyroidism

    4 Novoseek disease relationships for THRSP gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    thyroid diseases 31.5 1 8767512 (1)
    breast cancer 18.3 20 16300755 (5), 16809441 (5), 19116881 (4), 16552628 (3) (see all 5)
    metastasis 0 2 16552628 (1), 16809441 (1)
    tumors 0 8 16552628 (3), 16300755 (2), 9618526 (1)

    Human Genome Epidemiology (HuGE) Navigator: THRSP (4 documents)

    Export disorders for THRSP gene to outside databases

    Publications
    for THRSP gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for THRSP gene, integrated from 9 sources (see all 56):
    (articles sorted by number of sources associating them with THRSP)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and initial characterization of human and mouse Spot 14 genes. (PubMed id 9003802)1, 2, 3 Grillasca J.-P.... Planells R. (1997)
    2. Human spot 14 protein interacts physically and functionally with the thyroid receptor. (PubMed id 17418816)1, 2, 9 Chou W.Y....Huang S.M. (2007)
    3. Human Spot 14 protein is a p53-dependent transcriptional coactivator via the recruitment of thyroid receptor and Zac1. (PubMed id 18299245)1, 2 Chou W.Y....Huang S.M. (2008)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Cloning, expression and regulation of the human S14 gene. (PubMed id 9027365)1, 9 Ota Y....Mariash C.N. (1997)
    6. The 'Spot 14' gene resides on the telomeric end of the 11q13 amplicon and is expressed in lipogenic breast cancers: implications for control of tumor metabolism. (PubMed id 9618526)1, 9 Moncur J.T....Kinlaw W.B. (1998)
    7. Expression, purification and preliminary crystallogra phic analysis of human thyroid hormone responsive protein. (PubMed id 21821901)1 Zhang W....Bartlam M. (2011)
    8. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1 Bailey S.D....Anand S. (2010)
    9. Gene-centric association signals for lipids and apoli poproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (2009)
    10. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)

    External Searches for THRSP gene

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Genome Databases showing THRSP gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7069 HGNC: 11800 AceView: THRSP Ensembl:ENSG00000151365 euGenes: HUgn7069
    ECgene: THRSP H-InvDB: THRSP

    Other Databases showing THRSP gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing THRSP gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for THRSP Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for THRSP Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for THRSP gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for THRSP gene:
    Search GeneIP for patents involving THRSP

    GeneCards and IP:
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