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THRB Gene

protein-coding   GIFtS: 70
GCID: GC03M024158

Thyroid Hormone Receptor, Beta

(Previous names: thyroid hormone receptor, beta (avian erythroblastic leukemia...)
(Previous symbols: ERBA2, PRTH)
Microbiology & Infectious Diseases Congress
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Thyroid Hormone Receptor, Beta1 2     Thyroid Hormone Receptor Beta 11
ERBA21 2 3 5     Thyroid Hormone Receptor, Beta (Avian Erythroblastic Leukemia Viral
(V-Erb-A) Oncogene Homolog 2)1
PRTH1 2 5     C-ERBA-22
THR12 3 5     C-ERBA-BETA2
Thyroid Hormone Receptor, Beta (Erythroblastic Leukemia Viral (V-Erb-A)
Oncogene Homolog 2, Avian)1 2
     GRTH2
Oncogene ERBA21 2     THRB12
Nuclear Receptor Subfamily 1 Group A Member 22 3     THRB22
NR1A22 3     Thyroid Hormone Nuclear Receptor Beta Variant 12
Avian Erythroblastic Leukemia Viral (V-Erb-A) Oncogene Homolog 21     Thyroid Hormone Receptor Beta2
Generalized Resistance To Thyroid Hormone1     c-erbA-23
Pituitary Resistance To Thyroid Hormone1     c-erbA-beta3

External Ids:    HGNC: 117991   Entrez Gene: 70682   Ensembl: ENSG000001510907   OMIM: 1901605   UniProtKB: P108283   

Export aliases for THRB gene to outside databases

Previous GC identifers: GC03M023830 GC03M024013 GC03M024138 GC03M024139 GC03M024104


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for THRB Gene:
The protein encoded by this gene is a nuclear hormone receptor for triiodothyronine. It is one of the several
receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone.
Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may
mediate different functions of thyroid hormone. Mutations in this gene are known to be a cause of generalized
thyroid hormone resistance (GTHR), a syndrome characterized by goiter and high levels of circulating thyroid
hormone (T3-T4), with normal or slightly elevated thyroid stimulating hormone (TSH). Several alternatively
spliced transcript variants encoding the same protein have been observed for this gene. (provided by RefSeq, Jul
2008)

GeneCards Summary for THRB Gene:
THRB (thyroid hormone receptor, beta) is a protein-coding gene. Diseases associated with THRB include thyroiditis, and thyroid hormone resistance, selective pituitary. GO annotations related to this gene include enzyme binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is VDR.

UniProtKB/Swiss-Prot: THB_HUMAN, P10828
Function: Nuclear hormone receptor that can act as a repressor or activator of transcription. High affinity
receptor for thyroid hormones, including triiodothyronine and thyroxine

Gene Wiki entry for THRB (Thyroid hormone receptor beta) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000003.12  NT_022517.19  NC_018914.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the THRB gene promoter:
         Egr-2   Sp1   POU2F1   POU2F1a   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): THRB promoter sequence
   Search Chromatin IP Primers for THRB

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat THRB


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p24.2   Ensembl cytogenetic band:  3p24.2   HGNC cytogenetic band: 3p24.2

THRB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
THRB gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M024158:  view genomic region     (about GC identifiers)

Start:
24,158,644 bp from pter      End:
24,536,773 bp from pter
Size:
378,130 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: THB_HUMAN, P10828 (See protein sequence)
Recommended Name: Thyroid hormone receptor beta  
Size: 461 amino acids; 52788 Da
Subunit: Binds DNA as a dimer; homodimer and heterodimer with RXRA. Interacts with the coactivators NCOA1/SRC1,
NCOA2/GRIP1, NCOA7 and MED1/TRAP220 in a ligand-inducible manner. Interacts with the corepressor NCOR1 in absence
of ligand. Interacts with C1D (By similarity). Interacts with NR2F6; the interaction impairs the binding of the
THRB homodimer and THRB:RXRB heterodimer to T3 response elements. Interacts with PRMT2 and THRSP
Sequence caution: Sequence=AAA35677.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=CAA28412.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Selected PDB 3D structures from and Proteopedia for THRB (see all 18):
1BSX (3D)        1N46 (3D)        1NAX (3D)        1NQ0 (3D)        1NQ1 (3D)        1NQ2 (3D)    
Secondary accessions: B3KU79 P37243 Q13986 Q3KP35 Q6WGL2 Q9UD41
Alternative splicing: 2 isoforms:  P10828-1   P10828-2, P37243-1   

Explore the universe of human proteins at neXtProt for THRB: NX_P10828

Explore proteomics data for THRB at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See THRB Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_000452.2  NP_001121648.1  NP_001121649.1  NP_001239563.1  

    ENSEMBL proteins: 
     ENSP00000348827   ENSP00000414444   ENSP00000280696   ENSP00000414100   ENSP00000404898  
     ENSP00000388467   ENSP00000414910   ENSP00000395362   ENSP00000399573   ENSP00000404233  
     ENSP00000393932   ENSP00000379904  
    Reactome Protein details: P10828

    THRB Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for THRB
    OriGene Protein Over-expression Lysate for THRB
    OriGene MassSpec for THRB
    OriGene Custom Protein Services for THRB
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    Novus Biologicals THRB Protein
    Novus Biologicals THRB Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

    THRB Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of THRB
    R&D Systems Antibodies for THRB (TR beta 1/NR1A2)
    OriGene Antibodies for THRB
    OriGene Custom Antibody Services for THRB
    Novus Biologicals THRB Antibodies
    Abcam antibodies for THRB (P10828, P37243)
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibody for THRB
    LSBio Antibodies in human, mouse, rat for THRB

    THRB Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for THRB
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    NR: Nuclear hormone receptors

    IUPHAR Guide to PHARMACOLOGY protein family classification: Thyroid hormone receptor-beta
    1A. Thyroid Hormone Receptors

    Selected InterPro protein domains (see all 6):
     IPR013088 Znf_NHR/GATA
     IPR008946 Nucl_hormone_rcpt_ligand-bd
     IPR000536 Nucl_hrmn_rcpt_lig-bd_core
     IPR001628 Znf_hrmn_rcpt
     IPR001723 Str_hrmn_rcpt

    Graphical View of Domain Structure for InterPro Entry P10828

    ProtoNet protein and cluster: P10828

    2 Blocks protein domains:
    IPB001723 Steroid hormone receptor signature
    IPB001728 Thyroid hormone receptor signature


    UniProtKB/Swiss-Prot: THB_HUMAN, P10828
    Domain: Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal
    ligand-binding domain
    Similarity: Belongs to the nuclear hormone receptor family. NR1 subfamily
    Similarity: Contains 1 nuclear receptor DNA-binding domain


    THRB for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: THB_HUMAN, P10828
    Function: Nuclear hormone receptor that can act as a repressor or activator of transcription. High affinity
    receptor for thyroid hormones, including triiodothyronine and thyroxine

         Genatlas biochemistry entry for THRB:
    thyroid hormone receptor,beta,essential for inner ear development,steroid/thyroid hormone receptor superfamily

         Gene Ontology (GO): Selected molecular function terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding TAS1618799
    GO:0003700sequence-specific DNA binding transcription factor activity NAS1618799
    GO:0003707steroid hormone receptor activity IEA--
    GO:0003714transcription corepressor activity TAS1618799
    GO:0004887thyroid hormone receptor activity IDA15466465
         
    THRB for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for THRB:
     Elongated cells with protrusio 

         Selected MGI mutant phenotypes (inferred from 13 alleles(MGI details for Thrb) (see all 20):
     behavior/neurological  cardiovascular system  craniofacial  digestive/alimentary  endocrine/exocrine gland 
     growth/size/body  hearing/vestibular/ear  hematopoietic system  homeostasis/metabolism  immune system 
     limbs/digits/tail  mortality/aging  muscle  nervous system  no phenotypic analysis 

    THRB for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for THRB: Thrbtm1Few Thrbtm1Df Thrbtm4Few

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for THRB
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for THRB

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for THRB
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for THRB

    miRNA
    Products:
        
    miRTarBase miRNAs that target THRB:
    hsa-mir-27a-3p (MIRT005425), hsa-mir-204-5p (MIRT005524)

    Block miRNA regulation of human, mouse, rat THRB using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate THRB (see all 189):
    hsa-miR-124* hsa-miR-411* hsa-miR-100* hsa-miR-520f hsa-miR-106a hsa-miR-1224-3p hsa-miR-199a-3p hsa-miR-128
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for THRB
    Predesigned siRNA for gene silencing in human, mouse, rat THRB

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for THRB

    Clone
    Products:
         
    OriGene clones in human, mouse for THRB (see all 18)
    OriGene ORF clones in mouse, rat for THRB
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): THRB (NM_000461)
    Sino Biological Human cDNA Clone for THRB
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for THRB
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat THRB

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for THRB
    Browse ESI BIO Cell Lines and PureStem Progenitors for THRB 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for THRB


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    THB_HUMAN, P10828: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus TAS1618799
    GO:0005654nucleoplasm TAS--

    THRB for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for THRB About   (see all 7)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Nuclear Receptor transcription pathway
    Nuclear Receptor transcription pathway0.67
    Nuclear Receptors0.67
    2Gene Expression
    Generic Transcription Pathway0.40
    Gene Expression0.40
    3Peptide ligand-binding receptors
    Neuroactive ligand-receptor interaction0.36
    4Transcription Role of VDR in regulation of genes involved in osteoporosis
    Transcription Role of VDR in regulation of genes involved in osteoporosis
    5Thyroid hormone signaling pathway
    Thyroid hormone signaling pathway

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for THRB
        Transcription Role of VDR in regulation of genes involved in osteoporosis

    2 BioSystems Pathways for THRB
        Nuclear Receptors
    SIDS Susceptibility Pathways


    1 Reactome Pathway for THRB
        Nuclear Receptor transcription pathway


    2 Kegg Pathways  (Kegg details for THRB):
        Neuroactive ligand-receptor interaction
    Thyroid hormone signaling pathway


    THRB for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including THRB: 
              Obesity in human mouse rat
              Nuclear Receptors & Coregulators in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for THRB

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for THRB (P108282, 3 ENSP000003488274) via UniProtKB, MINT, STRING, and/or I2D (see all 111)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MED25Q71SY52, 3, ENSP000003267674MINT-5210013 I2D: score=1 STRING: ENSP00000326767
    ENSG00000206289P287023I2D: score=3 
    ENSG00000227322P287023I2D: score=3 
    ENSG00000228333P287023I2D: score=3 
    ENSG00000231321P287023I2D: score=3 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 16):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IEA--
    GO:0006351transcription, DNA-templated TAS1618799
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0006357regulation of transcription from RNA polymerase II promoter ----
    GO:0006367transcription initiation from RNA polymerase II promoter TAS--

    THRB for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for THRB (THB)

    1 HMDB Compound for THRB    About this table
    CompoundSynonyms CAS #PubMed Ids
    Liothyronine3,3',5-Triiodo-L-thyronine (see all 20)6893-02-3--

    Selected DrugBank Compounds for THRB (see all 11)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Liotrix-- 8065-29-0targetagonist20151830 12668276 16099238 17139284 16053391 17016423 17315033 12776178 18816177 10592235
    LiothyronineL-Liothyronine (see all 5)6893-02-3targetagonist11159893 12668276 16099238 17139284 17016423 17315033 12776178 10592235
    Dextrothyroxine-- 51-49-0targetagonist12668276 16099238 17139284 17016423 17315033 12776178 10592235
    Levothyroxine(-)-Thyroxine (see all 13)51-48-9targetagonist20151830 16053391 17016423 18816177
    2-[4-(4-Hydroxy-3-Isopropyl-Phenoxy)-3,5-Dimethyl-Phenyl]-2h-[1,2,4]Triazine-3,5-Dione-- --target--17139284 17016423 10592235
    3,5-Dichloro-4-[(4-Hydroxy-3-Isopropylphenoxy)Phenylacetic Acid-- --target--17139284 17016423 10592235
    GC-24-- --target--17139284 17016423
    [3,5-Dibromo-4-(4-Hydroxy-3-Phenethylcarbamoyl-Phenoxy)-Phenyl]-Acetic Acid-- --target--17139284 17016423
    [4-(4-Hydroxy-3-Iodo-Phenoxy)-3,5-Diiodo-Phenyl]-Acetic Acid-- --target--17139284 17016423
    1-(4-HEXYLPHENYL)PROP-2-EN-1-ONE-- --target--10592235

    7 IUPHAR Ligands for THRB (Thyroid hormone receptor-beta)    About this table
    LigandTypeActionAffinityPubmed IDs
    3,3',5-triiodothyroacetic acid
    AgonistAgonist10.72158622
    GC-1
    AgonistAgonist10.17269396 9653548
    T3
    AgonistAgonist10.112109914
    KB-141
    AgonistAgonist8.9612888625
    T4
    AgonistAgonist8.522158622
    reverse triiodothyronine
    AgonistAgonist7.342158622
    NH-3
    AntagonistAntagonist7.0312109914

    Selected Novoseek inferred chemical compound relationships for THRB gene (see all 31)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    prt-h 90.6 5 7920008 (1), 10022392 (1), 9350446 (1), 9534036 (1) (see all 5)
    triiodothyroacetic acid 84.3 1 7608251 (1)
    triiodothyronine 73.7 2 17363077 (1), 19378427 (1)
    thyroxine 59.8 2 20237409 (1), 10090317 (1)
    desethylamiodarone 58.9 4 11007966 (2), 10350052 (1)
    retinoic acid 52.3 7 15336696 (2), 8472843 (1), 16216492 (1), 7971966 (1) (see all 6)
    leucine 39 2 9849963 (1), 8990194 (1)
    adenine 37.1 2 10710882 (1), 9459636 (1)
    cytosine 36.7 1 17596672 (1)
    threonine 35.6 6 8786093 (1), 10710882 (1), 15133108 (1), 1502193 (1) (see all 5)



    THRB for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for THRB gene (4 alternative transcripts): 
    NM_000461.4  NM_001128176.2  NM_001128177.1  NM_001252634.1  

    Unigene Cluster for THRB:

    Thyroid hormone receptor, beta
    Hs.187861  [show with all ESTs]
    Unigene Representative Sequence: NM_001252634
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000356447(uc003cdd.3 uc021wuc.1) ENST00000416420(uc003cdc.3 uc021wud.1)
    ENST00000280696(uc003cda.1) ENST00000413780 ENST00000415021 ENST00000447875
    ENST00000453729(uc003cde.1) ENST00000431815 ENST00000447414 ENST00000428492
    ENST00000418247 ENST00000396671(uc003ccz.4 uc010hfe.3 uc003ccy.4 uc003ccx.4)

    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    Block miRNA regulation of human, mouse, rat THRB using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate THRB (see all 189):
    hsa-miR-124* hsa-miR-411* hsa-miR-100* hsa-miR-520f hsa-miR-106a hsa-miR-1224-3p hsa-miR-199a-3p hsa-miR-128
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for THRB
    Predesigned siRNA for gene silencing in human, mouse, rat THRB
    Clone
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    OriGene clones in human, mouse for THRB (see all 18)
    OriGene ORF clones in mouse, rat for THRB
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): THRB (NM_000461)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for THRB
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat THRB
    Primer
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    OriGene qPCR primer pairs and template standards for THRB
    OriGene qSTAR qPCR primer pairs in human, mouse for THRB
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat THRB
      QuantiTect SYBR Green Assays in human, mouse, rat THRB
      QuantiFast Probe-based Assays in human, mouse, rat THRB

    Additional mRNA sequence: 

    AB307687.1 AK095776.1 AK096628.1 AK096885.1 AK098084.1 AK124042.1 AY286465.1 AY286466.1 
    AY286467.1 AY286468.1 AY286469.1 AY286470.1 AY286471.1 BC028910.1 BC106929.1 BC106930.1 
    GQ456948.1 GQ456949.1 GQ456950.1 GQ456951.1 GQ869477.1 GQ869479.1 GQ919288.1 HQ692825.1 
    M26747.1 X04707.1 X74497.1 

    11 DOTS entries:

    DT.314132  DT.455589  DT.40131089  DT.102839051  DT.75190909  DT.100010665  DT.100775058  DT.97825383 
    DT.120902200  DT.40131088  DT.443533 

    Selected AceView cDNA sequences (see all 100):

    AV682743 BU157865 AL713041 BF431989 BU739344 AA258459 AI193412 BQ879477 
    AI590400 AI863074 BX489919 AI312948 AI767555 AA704234 BM715006 AI192925 
    BC028910 NM_000461 BX491508 BX105866 AK095776 M26747 AW020715 BQ188451 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for THRB    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b
    SP1:                    -                                                               
    SP2:              -                                                                     
    SP3:              -     -     -                                                         


    ECgene alternative splicing isoforms for THRB

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    THRB expression in normal human tissues (normalized intensities)      THRB embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AACTGAATTT
    THRB Expression
    About this image


    THRB expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Neurons
             Cone Precursor Cells Outer Nuclear Layer
     
     Eye (Sensory Organs)    fully expand to see all 2 entries
             Cone Precursor Cells Outer Nuclear Layer
     
     Testis (Reproductive System)
             Sertoli cells Seminiferous Tubules
    THRB Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    THRB Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.187861
        Pathway & Disease-focused RT2 Profiler PCR Arrays including THRB: 
              Obesity in human mouse rat
              Nuclear Receptors & Coregulators in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for THRB gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Thrb1 , 5 thyroid hormone receptor beta1, 5 90.6(n)1
    96.53(a)1
      14 (7.08 cM)5
    218341  NM_001113417.11  NP_001106888.11 
     176609605 
    chicken
    (Gallus gallus)
    Aves THRB1 thyroid hormone receptor, beta 88.32(n)
    97.28(a)
      396431  NM_001252221.1  NP_001239150.1 
    lizard
    (Anolis carolinensis)
    Reptilia THRB6
    thyroid hormone receptor, beta
    68(a)
    1 ↔ 1
    GL343357.1(452057-583918)
    African clawed frog
    (Xenopus laevis)
    Amphibia LOC3977342 X.laevis thyroid hormone receptor beta B2 81.94(n)    M35361.1 
    zebrafish
    (Danio rerio)
    Actinopterygii thrb2 thyroid hormone receptor beta 81.44(n)   30607  AF109732.1 


    ENSEMBL Gene Tree for THRB (if available)
    TreeFam Gene Tree for THRB (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for THRB gene
    VDR2  PPARD2  RARG2  NR1I22  PPARA2  RARA2  NR1H42  NR1D22  
    RARB2  RORA2  RORB2  RORC2  NR1D12  NR1I32  PPARG2  NR1H22  
    THRA2  NR1H32  
    Selected SIMAP similar genes for THRB using alignment to 8 protein entries:     THB_HUMAN (see all proteins) (see all similar genes):
    NR1A2    THRA    NR1A1    NR3C2    HNF4G    NR2C2
    NR2F1    RXRB    NR1F1    NR1I3    RORA    VDR
    NR5A1    NR5A2    HNF4alpha    NR6A1    RORC    NR1I2

    THRB for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for THRB (see all 8194)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs289334081,2,,4
    CGeneralized thyroid hormone resistance (GTHR)4 pathogenic124104745(-) TCCCCA/CCTTTG 8 T P mis1 trp30--------
    rs289999701,2,,4
    CGeneralized thyroid hormone resistance (GTHR)4 pathogenic124109445(-) TGGGGA/G/TTCTTG 12 D G V mis10--------
    VAR_0046344
    Selective pituitary thyroid hormone resistance (PRTH)4--see VAR_0046342 R H mis40--------
    VAR_0046504
    Generalized thyroid hormone resistance (GTHR)4--see VAR_0046502 M V mis40--------
    VAR_0046324
    Generalized thyroid hormone resistance (GTHR)4--see VAR_0046322 A T mis40--------
    VAR_0046374
    Generalized thyroid hormone resistance (GTHR)4--see VAR_0046372 R H mis40--------
    VAR_0590414
    Generalized thyroid hormone resistance (GTHR)4--see VAR_0590412 A G mis40--------
    VAR_0046544
    Generalized thyroid hormone resistance (GTHR)4--see VAR_0046542 P S mis40--------
    VAR_0046474
    Generalized thyroid hormone resistance (GTHR)4--see VAR_0046472 V E mis40--------
    VAR_0046444
    Generalized thyroid hormone resistance (GTHR)4--see VAR_0046442 G S mis40--------

    HapMap Linkage Disequilibrium report for THRB (24158644 - 24408644 bp, first 250kb of THRB)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for THRB (see all 21):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2677194CNV Deletion23128226
    esv2725044CNV Deletion23290073
    esv2725045CNV Deletion23290073
    esv2725046CNV Deletion23290073
    esv2725043CNV Deletion23290073
    dgv812e201CNV Deletion23290073
    esv2288146CNV Deletion18987734
    nsv507088CNV Insertion20534489
    esv271750CNV Insertion20981092
    nsv3733CNV Loss18451855

    Human Gene Mutation Database (HGMD): THRB
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing THRB
    DNA2.0 Custom Variant and Variant Library Synthesis for THRB

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 190160   
    OMIM disorders: 188570  274300  145650  
    UniProtKB/Swiss-Prot: THB_HUMAN, P10828
  • Generalized thyroid hormone resistance (GTHR) [MIM:188570]: A disease characterized by goiter, abnormal
    mental functions, increased susceptibility to infections, abnormal growth and bone maturation, tachycardia and
    deafness. Affected individuals may also have attention deficit-hyperactivity disorders (ADHD) and language
    difficulties. GTHR patients also have high levels of circulating thyroid hormones (T3-T4), with normal or
    slightly elevated thyroid stimulating hormone (TSH). Note=The disease is caused by mutations affecting the gene
    represented in this entry
  • Generalized thyroid hormone resistance autosomal recessive (GTHRAR) [MIM:274300]: An autosomal recessive
    disorder characterized by goiter, clinical euthyroidism, end-organ unresponsiveness to thyroid hormone, abnormal
    growth and bone maturation, and deafness. Patients also have high levels of circulating thyroid hormones, with
    elevated thyroid stimulating hormone. Note=The disease is caused by mutations affecting the gene represented in
    this entry
  • Selective pituitary thyroid hormone resistance (PRTH) [MIM:145650]: Variant form of thyroid hormone
    resistance and is characterized by clinical hyperthyroidism, with elevated free thyroid hormones, but
    inappropriately normal serum TSH. Unlike GRTH, where the syndrome usually segregates with a dominant allele, the
    mode of inheritance in PRTH has not been established. Note=The disease is caused by mutations affecting the gene
    represented in this entry

  • Selected diseases for THRB (see all 53):    About MalaCards
    thyroiditis    thyroid hormone resistance, selective pituitary    generalized resistance to thyroid hormone    thyroid hormone resistance, autosomal recessive
    thyroid hormone resistance syndrome    hypothyroidism, congenital, nongoitrous, 6    goiter    hyperthyroxinemia
    thyroid cancer    thyrotoxicosis    attention deficit hyperactivity disorder    autoimmune thyroiditis
    von hippel-lindau disease    wilson disease    follicular thyroid carcinoma    leukemia
    renal clear cell carcinoma    short stature    graves' disease    hyperthyroidism

    6 diseases from the University of Copenhagen DISEASES database for THRB:
    Hypothyroidism     Goiter     Thyrotoxicosis     Hyperthyroidism
    Attention deficit hyperactivity disorder     Thyroid cancer

    THRB for disorders           About GeneDecksing

    Selected Novoseek inferred disease relationships for THRB gene (see all 19)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    thyroid hormone resistance 96.8 28 15031774 (2), 8054858 (1), 15913586 (1), 17596672 (1) (see all 26)
    goiter 72.9 1 11167935 (1)
    thyroid follicular carcinoma 71.3 6 17653082 (1), 18997818 (1), 18474620 (1), 16314832 (1) (see all 5)
    follicular thyroid cancer 64.4 1 16002527 (1)
    thyroid cancer 57.9 5 12429043 (1), 17210745 (1), 18474620 (1), 16002527 (1) (see all 5)
    thyroid diseases 44.5 1 15860414 (1)
    autoimmune thyroid disease 42 1 19169471 (1)
    attention-deficit hyperactivity disorder 35.8 1 8200958 (1)
    short stature 27.9 1 8837325 (1)
    graves disease 25.1 3 8748133 (2), 20151830 (1)

    Genetic Association Database (GAD): THRB
    Human Genome Epidemiology (HuGE) Navigator: THRB (143 documents)

    Export disorders for THRB gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for THRB gene, integrated from 10 sources (see all 412):
    (articles sorted by number of sources associating them with THRB)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Structural analysis of human thyroid hormone receptor beta gene. (PubMed id 1973914)1, 2, 3 Sakurai A.... Degroot L.J. (Mol. Cell. Endocrinol. 1990)
    2. Identification and consequences of polymorphisms in the thyroid hormone receptor alpha and beta genes. (PubMed id 18844476)1, 4, 9 SA...Visser T.J. (Thyroid 2008)
    3. Genotyping of resistance to thyroid hormone in South American population. Identification of seven novel missense mutations in the human thyroid hormone receptor beta gene. (PubMed id 19268523)1, 2, 9 Rivolta C.M.... Targovnik H.M. (Mol. Cell. Probes 2009)
    4. Multiple messenger ribonucleic acid variants regulate cell-specific expression of human thyroid hormone receptor beta1. (PubMed id 15105435)1, 2, 9 Frankton S.... Williams G.R. (Mol. Endocrinol. 2004)
    5. Thyroid hormone receptors/THR genes in human cancer. (PubMed id 12668276)1, 7, 9 GonzA!lez-Sancho J.M....MuA+oz A. (Cancer Lett. 2003)
    6. T426I a new mutation in the thyroid hormone receptor gene in a sporadic patient with resistance to thyroid hormone and dysmorphism. (PubMed id 10660344)1, 2, 9 Menzaghi C.... de Filippis V. (Hum. Mutat. 1998)
    7. A new point mutation (C446R) in the thyroid hormone receptor-beta gene of a family with resistance to thyroid hormone. (PubMed id 8175986)1, 2, 9 Weiss R.E....Refetoff S. (J. Clin. Endocrinol. Metab. 1994)
    8. Genetic analysis of 29 kindreds with generalized and pituitary resistance to thyroid hormone. Identification of thirteen novel mutations in the thyroid hormone receptor beta gene. (PubMed id 8040303)1, 3, 9 Adams M....Chatterjee K.K. (J. Clin. Invest. 1994)
    9. Identical mutations in unrelated families with generalized resistance to thyroid hormone occur in cytosine-guanine-rich areas of the thyroid hormone receptor beta gene. Analysis of 15 families. (PubMed id 8514853)1, 2, 9 Weiss R.E.... Refetoff S. (J. Clin. Invest. 1993)
    10. A point mutation in the 3,5,3'-triiodothyronine-binding domain of thyroid hormone receptor-beta associated with a family with generalized resistance to thyroid hormone. (PubMed id 1619012)1, 2, 9 Shuto Y.... Okazaki T. (J. Clin. Endocrinol. Metab. 1992)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 7068 HGNC: 11799 AceView: THRB Ensembl:ENSG00000151090 euGenes: HUgn7068
    ECgene: THRB Kegg: 7068 H-InvDB: THRB

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for THRB Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for THRB Genetics and Cytogenetics in Oncology and Haematology
    GeneReviewshttp://www.ncbi.nlm.nih.gov/books/NBK1116/?term=THRB[genesymbol]

    (Patent information from GeneIP,
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    Patent Information for THRB gene:
    Search GeneIP for patents involving THRB

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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