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THRAP3 Gene

protein-coding   GIFtS: 50
GCID: GC01P036690

Thyroid Hormone Receptor Associated Protein 3

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Thyroid Hormone Receptor Associated Protein 31 2
Thyroid Hormone Receptor-Associated Protein Complex 150 KDa Component2 3
TRAP1502 3
Thyroid Hormone Receptor-Associated Protein 32
Thyroid Hormone Receptor-Associated Protein, 150 KDa Subunit2
Trap1503

External Ids:    HGNC: 229641   Entrez Gene: 99672   Ensembl: ENSG000000541187   OMIM: 6038095   UniProtKB: Q9Y2W13   

Export aliases for THRAP3 gene to outside databases

Previous GC identifers: GC01P036117 GC01P036359 GC01P036462 GC01P034807


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for THRAP3 Gene:
THRAP3 (thyroid hormone receptor associated protein 3) is a protein-coding gene. Diseases associated with THRAP3 include thyroiditis, and dermatofibrosarcoma. GO annotations related to this gene include transcription coactivator activity and transcription cofactor activity. An important paralog of this gene is CXorf23.

UniProtKB/Swiss-Prot: TR150_HUMAN, Q9Y2W1
Function: Involved in pre-mRNA splicing. Remains associated with spliced mRNA after splicing which probably
involves interactions with the exon junction complex (EJC). Can trigger mRNA decay which seems to be independent
of nonsense-mediated decay involving premature stop codons (PTC) recognition. May be involved in nuclear mRNA
decay. Involved in regulation of signal-induced alternative splicing. During splicing of PTPRC/CD45 is proposed
to sequester phosphorylated SFPQ from PTPRC/CD45 pre-mRNA in resting T-cells. Involved in cyclin-D1/CCND1 mRNA
stability probably by acting as component of the SNARP complex which associates with both the 3'end of the CCND1
gene and its mRNA. Involved in response to DNA damage. Is excluced from DNA damage sites in a manner that
parallels transcription inhibition; the function may involve the SNARP complex. Initially thought to play a role
in transcriptional coactivation through its association with the TRAP complex; however, it is not regarded as a
stable Mediator complex subunit. Cooperatively with HELZ2, enhances the transcriptional activation mediated by
PPARG, maybe through the stabilization of the PPARG binding to DNA in presence of ligand. May play a role in the
terminal stage of adipocyte differentiation

Gene Wiki entry for THRAP3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the THRAP3 gene promoter:
         CREB   AREB6   STAT1   Spz1   FOXO4   deltaCREB   COMP1   Sox9   Msx-1   C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTHRAP3 promoter sequence
   Search Chromatin IP Primers for THRAP3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat THRAP3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p34.3   Ensembl cytogenetic band:  1p34.3   HGNC cytogenetic band: 1p34.3

THRAP3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
THRAP3 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P036690:  view genomic region     (about GC identifiers)

Start:
36,690,017 bp from pter      End:
36,770,958 bp from pter
Size:
80,942 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TR150_HUMAN, Q9Y2W1 (See protein sequence)
Recommended Name: Thyroid hormone receptor-associated protein 3  
Size: 955 amino acids; 108666 Da
Subunit: Associated with the large multiprotein complex TRAP (Mediator complex-like). Interacts with SFPQ; the
interaction is dependent on SFPQ phosphorylation at 'Thr-687' and inhibits binding of SFPQ to an ESS1 exonic
splicing silencer element-containing RNA. Interacts with NXF1. Component of the SNARP complex which consists at
least of SNIP1, SNW1, THRAP3, BCLAF1 and PNN. Associated with spliced mRNP complexes. Interacts with HELZ2 and
PPARG
Sequence caution: Sequence=AAH37554.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential
poly-A sequence;
Secondary accessions: D3DPS5 Q5VTK6

Explore the universe of human proteins at neXtProt for THRAP3: NX_Q9Y2W1

Explore proteomics data for THRAP3 at MOPED

Post-translational modifications: 

  • ADP-ribosylation during genotoxic stress promotes accumulation in nuclear speckles1
  • Ubiquitination2 at Lys221, Lys470, Lys519, Lys558
  • Modification sites at PhosphoSitePlus

  • See THRAP3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_005110.2  
    ENSEMBL proteins: 
     ENSP00000346634   ENSP00000433825   ENSP00000433066  

    THRAP3 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for THRAP3

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR026667 THRAP3

    Graphical View of Domain Structure for InterPro Entry Q9Y2W1

    ProtoNet protein and cluster: Q9Y2W1


    THRAP3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TR150_HUMAN, Q9Y2W1
    Function: Involved in pre-mRNA splicing. Remains associated with spliced mRNA after splicing which probably
    involves interactions with the exon junction complex (EJC). Can trigger mRNA decay which seems to be independent
    of nonsense-mediated decay involving premature stop codons (PTC) recognition. May be involved in nuclear mRNA
    decay. Involved in regulation of signal-induced alternative splicing. During splicing of PTPRC/CD45 is proposed
    to sequester phosphorylated SFPQ from PTPRC/CD45 pre-mRNA in resting T-cells. Involved in cyclin-D1/CCND1 mRNA
    stability probably by acting as component of the SNARP complex which associates with both the 3'end of the CCND1
    gene and its mRNA. Involved in response to DNA damage. Is excluced from DNA damage sites in a manner that
    parallels transcription inhibition; the function may involve the SNARP complex. Initially thought to play a role
    in transcriptional coactivation through its association with the TRAP complex; however, it is not regarded as a
    stable Mediator complex subunit. Cooperatively with HELZ2, enhances the transcriptional activation mediated by
    PPARG, maybe through the stabilization of the PPARG binding to DNA in presence of ligand. May play a role in the
    terminal stage of adipocyte differentiation

         Gene Ontology (GO): Selected molecular function terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001104RNA polymerase II transcription cofactor activity IDA10198638
    GO:0003712transcription cofactor activity IDA12218053
    GO:0003713transcription coactivator activity IDA12037571
    GO:0004872receptor activity IDA12218053
    GO:0005515protein binding IPI18596238
         
    THRAP3 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for THRAP3
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    miRTarBase miRNAs that target THRAP3:
    hsa-mir-615-3p (MIRT040217), hsa-mir-125a-5p (MIRT045718), hsa-mir-877-5p (MIRT037365), hsa-mir-125b-5p (MIRT046049), hsa-mir-326 (MIRT043640), hsa-mir-877-3p (MIRT037155)

    Block miRNA regulation of human, mouse, rat THRAP3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate THRAP3 (see all 52):
    hsa-miR-219-1-3p hsa-miR-548j hsa-miR-579 hsa-miR-765 hsa-miR-624 hsa-miR-570 hsa-miR-3142 hsa-miR-3622b-3p
    SwitchGear 3'UTR luciferase reporter plasmidTHRAP3 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat THRAP3

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    GenScript: all cDNA clones in your preferred vector: THRAP3 (NM_005119)
    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat THRAP3

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for THRAP3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TR150_HUMAN, Q9Y2W1: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0016592mediator complex IDA10198638
    GO:0035145colocalizes with exon-exon junction complex IDA--
    GO:0043231intracellular membrane-bounded organelle ----

    THRAP3 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for THRAP3 About    
    See pathways by source

    SuperPathContained pathways About
    1PEDF Induced Signaling
    Glucocorticoid Receptor Signaling0.43

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for THRAP3
        Glucocorticoid Receptor Signaling


        Pathway & Disease-focused RT2 Profiler PCR Array including THRAP3: 
              Cardiotoxicity in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for THRAP3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for THRAP3 (Q9Y2W11, 2, 3 ENSP000003466344) via UniProtKB, MINT, STRING, and/or I2D (see all 829)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SMN1Q166372, 3, ENSP000003700834MINT-7945693 MINT-7947479 I2D: score=2 STRING: ENSP00000370083
    SMN2Q166372, 3, ENSP000003701194MINT-7945693 MINT-7947479 I2D: score=2 STRING: ENSP00000370119
    SNW1Q135731, 2, ENSP000002615314EBI-352039,EBI-632715 MINT-7945693 MINT-7947479 STRING: ENSP00000261531
    PARP1P098742, 3, ENSP000003557594MINT-7947479 I2D: score=1 STRING: ENSP00000355759
    EIF4A3P389191, 2EBI-352039,EBI-299104 MINT-7945693 MINT-7947479
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000381regulation of alternative mRNA splicing, via spliceosome IMP--
    GO:0000956nuclear-transcribed mRNA catabolic process IDA--
    GO:0006367transcription initiation from RNA polymerase II promoter IDA12218053
    GO:0006397mRNA processing IEA--
    GO:0008380RNA splicing IEA--

    THRAP3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for THRAP3 (TR150)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for THRAP3 gene: 
    NM_005119.3  

    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000354618(uc001cae.4 uc001caf.4) ENST00000469141(uc001cag.1)
    ENST00000478853 ENST00000466743
    miRNA
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    Block miRNA regulation of human, mouse, rat THRAP3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate THRAP3 (see all 52):
    hsa-miR-219-1-3p hsa-miR-548j hsa-miR-579 hsa-miR-765 hsa-miR-624 hsa-miR-570 hsa-miR-3142 hsa-miR-3622b-3p
    SwitchGear 3'UTR luciferase reporter plasmidTHRAP3 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for THRAP3
    Predesigned siRNA for gene silencing in human, mouse, rat THRAP3
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: THRAP3 (NM_005119)
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      QuantiTect SYBR Green Assays in human, mouse, rat THRAP3
      QuantiFast Probe-based Assays in human, mouse, rat THRAP3

    Selected AceView cDNA sequences (see all 363):

    BM803628 AI963887 BI871391 AI336933 BE772690 BQ049854 AW293890 BE208114 
    CB134585 CA438081 BX503284 BE328388 AI632604 BX482263 AW239179 BG392340 
    AI570614 W78984 BM674133 CR614227 BF111154 BP360521 AA357063 BP352791 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for THRAP3 (see all 8)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16
    SP1:                                                                                                                  
    SP2:                                                                                                                  
    SP3:              -     -     -                                                                                       
    SP4:                                                                                                                  
    SP5:                                                                                                                  


    ECgene alternative splicing isoforms for THRAP3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    THRAP3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTAGGGGGA
    THRAP3 Expression
    About this image


    THRAP3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 9) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Neural Tube (Nervous System)
             Telencephalon
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
    THRAP3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    THRAP3 Protein Expression

    UniProtKB/Swiss-Prot: TR150_HUMAN, Q9Y2W1
    Tissue specificity: Ubiquitous

        Pathway & Disease-focused RT2 Profiler PCR Array including THRAP3: 
              Cardiotoxicity in human mouse rat

    Primer
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    QuantiFast Probe-based Assays in human, mouse, rat THRAP3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for THRAP3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for THRAP3 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Thrap31 , 5 thyroid hormone receptor associated protein 31, 5 89.24(n)1
    93.61(a)1
      4 (60.00 cM)5
    2307531  NM_146153.31  NP_666265.31 
     1261640825 
    chicken
    (Gallus gallus)
    Aves THRAP31 thyroid hormone receptor associated protein 3 75.41(n)
    79.75(a)
      419623  NM_001030899.1  NP_001026070.1 
    lizard
    (Anolis carolinensis)
    Reptilia THRAP36
    thyroid hormone receptor associated protein 3
    72(a)
    1 ↔ 1
    GL343481.1(48324-78614)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.77452 Xenopus laevis, Similar to thyroid hormone receptor-associated more 74.97(n)    BC041220.1 
    zebrafish
    (Danio rerio)
    Actinopterygii CK027497.12   -- 74.07(n)   335042  CK027497.1 


    ENSEMBL Gene Tree for THRAP3 (if available)
    TreeFam Gene Tree for THRAP3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for THRAP3 gene
    CXorf232  BCLAF12  
    1 SIMAP similar gene for THRAP3 using alignment to 6 protein entries:     TR150_HUMAN (see all proteins):
    BCLAF1

    THRAP3 for paralogs           About GeneDecksing


    3 Pseudogenes.org Pseudogenes for THRAP3
    PGOHUM00000246929 PGOHUM00000237977 PGOHUM00000232593


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for THRAP3 (see all 1719)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1500981011,2
    --36688131(+) GCCTCC/TTGAGT 1 -- us2k10--------
    rs747547981,2
    C,F--36688164(+) CACCAC/TGCCCG 1 -- us2k11Minor allele frequency- T:0.50WA 2
    rs1879905571,2
    C--36688172(+) CCGGCA/TAATCT 1 -- us2k10--------
    rs1151215551,2
    F--36688173(+) CGGCTA/GATCTG 1 -- us2k11Minor allele frequency- G:0.01NA 120
    rs1808556021,2
    --36688181(+) CTGTAA/GTATTT 1 -- us2k10--------
    rs1167181631,2
    F--36688229(+) ATCACG/AAACTC 1 -- us2k11Minor allele frequency- A:0.02NA 120
    rs120821471,2
    C,H--36688421(+) ACCCAG/TAAAAT 1 -- us2k15Minor allele frequency- T:0.00NS EA NA 420
    rs726634031,2
    C--36688546(+) CCAACA/GTGGCG 1 -- us2k10--------
    rs1886135801,2
    C--36688674(+) AGTGAC/GCCAAA 1 -- us2k10--------
    rs755063571,2
    C--36688755(+) AATAAA/TATCAA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for THRAP3 (36690017 - 36770958 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for THRAP3 (see all 15):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2746830CNV Deletion23290073
    esv1002750CNV Deletion20482838
    esv1414937CNV Deletion17803354
    esv2746852CNV Deletion23290073
    esv2746863CNV Deletion23290073
    esv2544592CNV Deletion19546169
    esv2663119CNV Deletion23128226
    esv2746841CNV Deletion23290073
    esv2045078CNV Deletion18987734
    esv2125715CNV Deletion18987734

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603809    OMIM disorders: --

    8 diseases for THRAP3:    
    About MalaCards
    thyroiditis    dermatofibrosarcoma    tonsillitis    hiv-1
    breast cancer    cerebritis    prostatitis    endotheliitis


    THRAP3 for disorders           About GeneDecksing


    Export disorders for THRAP3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for THRAP3 gene, integrated from 10 sources (see all 78):
    (articles sorted by number of sources associating them with THRAP3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. THRAP3 interacts with HELZ2 and plays a novel role in adipocyte differentiation. (PubMed id 23525231)1, 2 Katano-Toki A.... Mori M. (Mol. Endocrinol. 2013)
    2. Proteome-wide identification of poly(ADP-Ribosyl)ation targets in different genotoxic stress responses. (PubMed id 24055347)1, 2 Jungmichel S....Nielsen M.L. (Mol. Cell 2013)
    3. Proteomic investigations reveal a role for RNA processing factor THRAP3 in the DNA damage response. (PubMed id 22424773)1, 2 Beli P.... Choudhary C. (Mol. Cell 2012)
    4. Regulation of cyclin D1 RNA stability by SNIP1. (PubMed id 18794151)1, 2 Bracken C.P....Perkins N.D. (Cancer Res. 2008)
    5. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (Nat. Biotechnol. 2006)
    6. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    7. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    8. Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry. (PubMed id 15144186)1, 2 Brill L.M....Peters E.C. (Anal. Chem. 2004)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. Identity between TRAP and SMCC complexes indicates novel pathways for the function of nuclear receptors and diverse mammalian activators. (PubMed id 10198638)1, 2 Ito M.... Roeder R.G. (Mol. Cell 1999)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9967 HGNC: 22964 AceView: THRAP3 Ensembl:ENSG00000054118 euGenes: HUgn9967
    ECgene: THRAP3 H-InvDB: THRAP3

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for THRAP3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for THRAP3 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for THRAP3 gene:
    Search GeneIP for patents involving THRAP3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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