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Aliases for THRAP3 Gene

Aliases for THRAP3 Gene

  • Thyroid Hormone Receptor Associated Protein 3 2 3 5
  • Thyroid Hormone Receptor-Associated Protein Complex 150 KDa Component 3 4
  • TRAP150 3 4
  • Thyroid Hormone Receptor-Associated Protein, 150 KDa Subunit 3
  • Thyroid Hormone Receptor-Associated Protein 3 3

External Ids for THRAP3 Gene

Previous GeneCards Identifiers for THRAP3 Gene

  • GC01P036117
  • GC01P036359
  • GC01P036462
  • GC01P036690
  • GC01P034807

Summaries for THRAP3 Gene

GeneCards Summary for THRAP3 Gene

THRAP3 (Thyroid Hormone Receptor Associated Protein 3) is a Protein Coding gene. Among its related pathways are Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) and Metabolism. GO annotations related to this gene include poly(A) RNA binding and transcription coactivator activity. An important paralog of this gene is BCLAF1.

UniProtKB/Swiss-Prot for THRAP3 Gene

  • Involved in pre-mRNA splicing. Remains associated with spliced mRNA after splicing which probably involves interactions with the exon junction complex (EJC). Can trigger mRNA decay which seems to be independent of nonsense-mediated decay involving premature stop codons (PTC) recognition. May be involved in nuclear mRNA decay. Involved in regulation of signal-induced alternative splicing. During splicing of PTPRC/CD45 is proposed to sequester phosphorylated SFPQ from PTPRC/CD45 pre-mRNA in resting T-cells. Involved in cyclin-D1/CCND1 mRNA stability probably by acting as component of the SNARP complex which associates with both the 3end of the CCND1 gene and its mRNA. Involved in response to DNA damage. Is excluced from DNA damage sites in a manner that parallels transcription inhibition; the function may involve the SNARP complex. Initially thought to play a role in transcriptional coactivation through its association with the TRAP complex; however, it is not regarded as a stable Mediator complex subunit. Cooperatively with HELZ2, enhances the transcriptional activation mediated by PPARG, maybe through the stabilization of the PPARG binding to DNA in presence of ligand. May play a role in the terminal stage of adipocyte differentiation. Plays a role in the positive regulation of the circadian clock. Acts as a coactivator of the CLOCK-ARNTL/BMAL1 heterodimer and promotes its transcriptional activator activity and binding to circadian target genes (PubMed:24043798).

Gene Wiki entry for THRAP3 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for THRAP3 Gene

Genomics for THRAP3 Gene

Regulatory Elements for THRAP3 Gene

Enhancers for THRAP3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F036154 0.2 ENCODE 48.6 -67.7 -67749 4.5 PKNOX1 ARID4B SIN3A ZNF2 ZNF548 FOS ZNF263 SP3 JUNB REST SFPQ ZMYM4 RPL5P4 THRAP3 MAP7D1 COL8A2 LOC105378647 EVA1B TRAPPC3 RN7SL131P
GH01F036384 1.3 Ensembl ENCODE 31.4 +163.7 163718 7.8 MLX FEZF1 DMAP1 YY1 ZNF416 ZNF143 ZNF263 SP3 NFYC TBX21 EVA1B THRAP3 LOC105378647 TRAPPC3 ENSG00000116883 SH3D21 STK40 ENSG00000201448 OSCP1 AGO1
GH01F035800 1 Ensembl ENCODE 29.8 -423.8 -423816 1.2 ZNF493 ZFP64 ZEB1 ZNF121 ZNF23 ZNF302 ZNF354C KLF7 SMARCA5 ZNF680 ZMYM1 SFPQ LOC653160 ZMYM4 RPL5P4 ENSG00000230163 THRAP3 LOC105378647 COL8A2 EVA1B
GH01F036463 0.9 ENCODE 22.9 +240.3 240302 2.9 CREB3L1 MLX ZFP64 FEZF1 DMAP1 YBX1 YY1 ZNF143 SP3 NFYC THRAP3 STK40 EVA1B OSCP1 LOC105378647 MRPS15 CSF3R
GH01F036148 1 FANTOM5 ENCODE 22.7 -73.5 -73545 4.9 HDGF PKNOX1 ARNT CREB3L1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SFPQ RPL5P4 MAP7D1 EVA1B THRAP3 LOC105378647 STK40 COL8A2 AGO3 SH3D21
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around THRAP3 on UCSC Golden Path with GeneCards custom track

Promoters for THRAP3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000281425 484 3001 HDGF PKNOX1 ARNT CREB3L1 MLX WRNIP1 ARID4B SIN3A FEZF1 DMAP1

Genomic Location for THRAP3 Gene

Chromosome:
1
Start:
36,224,416 bp from pter
End:
36,305,357 bp from pter
Size:
80,942 bases
Orientation:
Plus strand

Genomic View for THRAP3 Gene

Genes around THRAP3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
THRAP3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for THRAP3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for THRAP3 Gene

Proteins for THRAP3 Gene

  • Protein details for THRAP3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y2W1-TR150_HUMAN
    Recommended name:
    Thyroid hormone receptor-associated protein 3
    Protein Accession:
    Q9Y2W1
    Secondary Accessions:
    • D3DPS5
    • Q5VTK6

    Protein attributes for THRAP3 Gene

    Size:
    955 amino acids
    Molecular mass:
    108666 Da
    Quaternary structure:
    • Associated with the large multiprotein complex TRAP (Mediator complex-like). Interacts with SFPQ; the interaction is dependent on SFPQ phosphorylation at Thr-687 and inhibits binding of SFPQ to an ESS1 exonic splicing silencer element-containing RNA. Interacts with NXF1. Component of the SNARP complex which consists at least of SNIP1, SNW1, THRAP3, BCLAF1 and PNN. Associated with spliced mRNP complexes. Interacts with HELZ2 and PPARG. Interacts with CLOCK and ARNTL/BMAL1 (By similarity). Component of the WTAP complex composed of WTAP, ZC3H13, CBLL1, KIAA1429, RBM15, BCLAF1 and THRAP3.
    SequenceCaution:
    • Sequence=AAH37554.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};

neXtProt entry for THRAP3 Gene

Post-translational modifications for THRAP3 Gene

  • ADP-ribosylation during genotoxic stress promotes accumulation in nuclear speckles.
  • Ubiquitination at Lys 221, Lys 470, Lys 519, and Lys 558
  • Modification sites at PhosphoSitePlus

Other Protein References for THRAP3 Gene

No data available for DME Specific Peptides for THRAP3 Gene

Domains & Families for THRAP3 Gene

Protein Domains for THRAP3 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with THRAP3: view

No data available for Gene Families and UniProtKB/Swiss-Prot for THRAP3 Gene

Function for THRAP3 Gene

Molecular function for THRAP3 Gene

UniProtKB/Swiss-Prot Function:
Involved in pre-mRNA splicing. Remains associated with spliced mRNA after splicing which probably involves interactions with the exon junction complex (EJC). Can trigger mRNA decay which seems to be independent of nonsense-mediated decay involving premature stop codons (PTC) recognition. May be involved in nuclear mRNA decay. Involved in regulation of signal-induced alternative splicing. During splicing of PTPRC/CD45 is proposed to sequester phosphorylated SFPQ from PTPRC/CD45 pre-mRNA in resting T-cells. Involved in cyclin-D1/CCND1 mRNA stability probably by acting as component of the SNARP complex which associates with both the 3end of the CCND1 gene and its mRNA. Involved in response to DNA damage. Is excluced from DNA damage sites in a manner that parallels transcription inhibition; the function may involve the SNARP complex. Initially thought to play a role in transcriptional coactivation through its association with the TRAP complex; however, it is not regarded as a stable Mediator complex subunit. Cooperatively with HELZ2, enhances the transcriptional activation mediated by PPARG, maybe through the stabilization of the PPARG binding to DNA in presence of ligand. May play a role in the terminal stage of adipocyte differentiation. Plays a role in the positive regulation of the circadian clock. Acts as a coactivator of the CLOCK-ARNTL/BMAL1 heterodimer and promotes its transcriptional activator activity and binding to circadian target genes (PubMed:24043798).

Gene Ontology (GO) - Molecular Function for THRAP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001046 core promoter sequence-specific DNA binding ISS --
GO:0001104 RNA polymerase II transcription cofactor activity IDA 10198638
GO:0003712 transcription cofactor activity IDA 12218053
GO:0003713 transcription coactivator activity IDA 12037571
GO:0004872 receptor activity IDA 12218053
genes like me logo Genes that share ontologies with THRAP3: view
genes like me logo Genes that share phenotypes with THRAP3: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for THRAP3 Gene

Localization for THRAP3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for THRAP3 Gene

Nucleus. Nucleus, nucleoplasm. Nucleus speckle.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for THRAP3 Gene COMPARTMENTS Subcellular localization image for THRAP3 gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for THRAP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 10235267
GO:0005654 nucleoplasm IEA,IDA 24100041
GO:0016592 mediator complex IDA 10198638
GO:0016607 nuclear speck IEA,IDA 24100041
GO:0035145 colocalizes_with exon-exon junction complex IDA 20123736
genes like me logo Genes that share ontologies with THRAP3: view

Pathways & Interactions for THRAP3 Gene

genes like me logo Genes that share pathways with THRAP3: view

SIGNOR curated interactions for THRAP3 Gene

Inactivates:

Gene Ontology (GO) - Biological Process for THRAP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000381 regulation of alternative mRNA splicing, via spliceosome IMP 20932480
GO:0000956 nuclear-transcribed mRNA catabolic process IDA 20123736
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006367 transcription initiation from RNA polymerase II promoter IDA 12218053
genes like me logo Genes that share ontologies with THRAP3: view

Transcripts for THRAP3 Gene

Unigene Clusters for THRAP3 Gene

Thyroid hormone receptor associated protein 3:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for THRAP3 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16
SP1:
SP2:
SP3: - - -
SP4:
SP5:
SP6: - - - -
SP7: - -
SP8: -

Relevant External Links for THRAP3 Gene

GeneLoc Exon Structure for
THRAP3
ECgene alternative splicing isoforms for
THRAP3

Expression for THRAP3 Gene

mRNA expression in normal human tissues for THRAP3 Gene

Protein differential expression in normal tissues from HIPED for THRAP3 Gene

This gene is overexpressed in Nasal epithelium (14.3) and Peripheral blood mononuclear cells (12.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for THRAP3 Gene



Protein tissue co-expression partners for THRAP3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of THRAP3 Gene:

THRAP3

SOURCE GeneReport for Unigene cluster for THRAP3 Gene:

Hs.744057

mRNA Expression by UniProt/SwissProt for THRAP3 Gene:

Q9Y2W1-TR150_HUMAN
Tissue specificity: Ubiquitous.
genes like me logo Genes that share expression patterns with THRAP3: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for THRAP3 Gene

Orthologs for THRAP3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for THRAP3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia THRAP3 34 35
  • 99.65 (n)
cow
(Bos Taurus)
Mammalia THRAP3 34 35
  • 93.36 (n)
dog
(Canis familiaris)
Mammalia THRAP3 34 35
  • 93.25 (n)
rat
(Rattus norvegicus)
Mammalia Thrap3 34
  • 89.46 (n)
mouse
(Mus musculus)
Mammalia Thrap3 34 16 35
  • 89.24 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia THRAP3 35
  • 88 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 79 (a)
OneToMany
-- 35
  • 69 (a)
OneToMany
chicken
(Gallus gallus)
Aves THRAP3 34 35
  • 75.41 (n)
lizard
(Anolis carolinensis)
Reptilia THRAP3 35
  • 72 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia thrap3 34
  • 63.29 (n)
LOC394509 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.7745 34
zebrafish
(Danio rerio)
Actinopterygii thrap3b 35
  • 40 (a)
OneToMany
BX321921.1 35
  • 39 (a)
OneToMany
thrap3a 35
  • 38 (a)
OneToMany
-- 34
Species where no ortholog for THRAP3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for THRAP3 Gene

ENSEMBL:
Gene Tree for THRAP3 (if available)
TreeFam:
Gene Tree for THRAP3 (if available)

Paralogs for THRAP3 Gene

Paralogs for THRAP3 Gene

(1) SIMAP similar genes for THRAP3 Gene using alignment to 6 proteins:

Pseudogenes.org Pseudogenes for THRAP3 Gene

genes like me logo Genes that share paralogs with THRAP3: view

Variants for THRAP3 Gene

Sequence variations from dbSNP and Humsavar for THRAP3 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs10643333 -- 36,232,955(+) TGCAA(-/CCTCTG)CCTCC intron-variant
rs10653561 -- 36,298,147(+) AAAAA(-/AA)TCACA intron-variant
rs1071841 -- 36,277,094(-) ctact(C/T)aggag intron-variant
rs10737165 -- 36,248,421(+) AGGCC(A/T)GACCC intron-variant
rs10737166 -- 36,278,142(+) TCACT(A/G)CAACT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for THRAP3 Gene

Variant ID Type Subtype PubMed ID
dgv74n106 OTHER inversion 24896259
esv1002750 CNV deletion 20482838
esv1414937 CNV deletion 17803354
esv2045078 CNV deletion 18987734
esv2125715 CNV deletion 18987734
esv2544592 CNV deletion 19546169
esv2663119 CNV deletion 23128226
esv2746830 CNV deletion 23290073
esv2746841 CNV deletion 23290073
esv2746852 CNV deletion 23290073
esv2746863 CNV deletion 23290073
esv2758931 CNV loss 17122850
esv3560737 CNV deletion 23714750
esv3560748 CNV deletion 23714750
esv3585731 CNV loss 21293372
nsv1077758 OTHER inversion 25765185
nsv1122329 CNV deletion 24896259
nsv1133839 CNV deletion 24896259
nsv160040 CNV deletion 16902084
nsv444 CNV deletion 18451855
nsv545994 CNV loss 21841781
nsv545995 CNV loss 21841781
nsv545997 CNV loss 21841781
nsv834691 CNV loss 17160897
nsv834702 CNV loss 17160897
nsv945880 CNV duplication 23825009
nsv945882 CNV duplication 23825009
nsv955436 CNV deletion 24416366
nsv956790 CNV deletion 24416366

Variation tolerance for THRAP3 Gene

Residual Variation Intolerance Score: 10% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.79; 47.39% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for THRAP3 Gene

Human Gene Mutation Database (HGMD)
THRAP3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
THRAP3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for THRAP3 Gene

Disorders for THRAP3 Gene

Relevant External Links for THRAP3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
THRAP3

No disorders were found for THRAP3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for THRAP3 Gene

Publications for THRAP3 Gene

  1. THRAP3 interacts with HELZ2 and plays a novel role in adipocyte differentiation. (PMID: 23525231) Katano-Toki A. … Mori M. (Mol. Endocrinol. 2013) 3 4 64
  2. A positive feedback loop links circadian clock factor CLOCK-BMAL1 to the basic transcriptional machinery. (PMID: 24043798) Lande-Diner L. … Weitz C.J. (Proc. Natl. Acad. Sci. U.S.A. 2013) 3 4 64
  3. Proteome-wide identification of poly(ADP-Ribosyl)ation targets in different genotoxic stress responses. (PMID: 24055347) Jungmichel S. … Nielsen M.L. (Mol. Cell 2013) 3 4 64
  4. Identification of Wilms' tumor 1-associating protein complex and its role in alternative splicing and the cell cycle. (PMID: 24100041) Horiuchi K. … Hamakubo T. (J. Biol. Chem. 2013) 3 4 64
  5. Proteomic investigations reveal a role for RNA processing factor THRAP3 in the DNA damage response. (PMID: 22424773) Beli P. … Choudhary C. (Mol. Cell 2012) 3 4 64

Products for THRAP3 Gene

Sources for THRAP3 Gene

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