Free for academic non-profit institutions. Other users need a Commercial license

Aliases for THRAP3 Gene

Aliases for THRAP3 Gene

  • Thyroid Hormone Receptor Associated Protein 3 2 3
  • Thyroid Hormone Receptor-Associated Protein Complex 150 KDa Component 3 4
  • TRAP150 3 4
  • Thyroid Hormone Receptor-Associated Protein, 150 KDa Subunit 3
  • Thyroid Hormone Receptor-Associated Protein 3 3

External Ids for THRAP3 Gene

Previous GeneCards Identifiers for THRAP3 Gene

  • GC01P036117
  • GC01P036359
  • GC01P036462
  • GC01P036690
  • GC01P034807

Summaries for THRAP3 Gene

GeneCards Summary for THRAP3 Gene

THRAP3 (Thyroid Hormone Receptor Associated Protein 3) is a Protein Coding gene. Among its related pathways are PEDF Induced Signaling. GO annotations related to this gene include transcription coactivator activity and transcription cofactor activity. An important paralog of this gene is CXorf23.

UniProtKB/Swiss-Prot for THRAP3 Gene

  • Involved in pre-mRNA splicing. Remains associated with spliced mRNA after splicing which probably involves interactions with the exon junction complex (EJC). Can trigger mRNA decay which seems to be independent of nonsense-mediated decay involving premature stop codons (PTC) recognition. May be involved in nuclear mRNA decay. Involved in regulation of signal-induced alternative splicing. During splicing of PTPRC/CD45 is proposed to sequester phosphorylated SFPQ from PTPRC/CD45 pre-mRNA in resting T-cells. Involved in cyclin-D1/CCND1 mRNA stability probably by acting as component of the SNARP complex which associates with both the 3end of the CCND1 gene and its mRNA. Involved in response to DNA damage. Is excluced from DNA damage sites in a manner that parallels transcription inhibition; the function may involve the SNARP complex. Initially thought to play a role in transcriptional coactivation through its association with the TRAP complex; however, it is not regarded as a stable Mediator complex subunit. Cooperatively with HELZ2, enhances the transcriptional activation mediated by PPARG, maybe through the stabilization of the PPARG binding to DNA in presence of ligand. May play a role in the terminal stage of adipocyte differentiation. Plays a role in the positive regulation of the circadian clock. Acts as a coactivator of the CLOCK-ARNTL/BMAL1 heterodimer and promotes its transcriptional activator activity and binding to circadian target genes (PubMed:24043798).

Gene Wiki entry for THRAP3 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for THRAP3 Gene

Genomics for THRAP3 Gene

Regulatory Elements for THRAP3 Gene

Genomic Location for THRAP3 Gene

Start:
36,224,416 bp from pter
End:
36,305,357 bp from pter
Size:
80,942 bases
Orientation:
Plus strand

Genomic View for THRAP3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for THRAP3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for THRAP3 Gene

Proteins for THRAP3 Gene

  • Protein details for THRAP3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y2W1-TR150_HUMAN
    Recommended name:
    Thyroid hormone receptor-associated protein 3
    Protein Accession:
    Q9Y2W1
    Secondary Accessions:
    • D3DPS5
    • Q5VTK6

    Protein attributes for THRAP3 Gene

    Size:
    955 amino acids
    Molecular mass:
    108666 Da
    Quaternary structure:
    • Associated with the large multiprotein complex TRAP (Mediator complex-like). Interacts with SFPQ; the interaction is dependent on SFPQ phosphorylation at Thr-687 and inhibits binding of SFPQ to an ESS1 exonic splicing silencer element-containing RNA. Interacts with NXF1. Component of the SNARP complex which consists at least of SNIP1, SNW1, THRAP3, BCLAF1 and PNN. Associated with spliced mRNP complexes. Interacts with HELZ2 and PPARG. Interacts with CLOCK and ARNTL/BMAL1 (By similarity).
    SequenceCaution:
    • Sequence=AAH37554.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};

neXtProt entry for THRAP3 Gene

Proteomics data for THRAP3 Gene at MOPED

Post-translational modifications for THRAP3 Gene

  • ADP-ribosylation during genotoxic stress promotes accumulation in nuclear speckles
  • Ubiquitination at Lys221, Lys470, Lys519, and Lys558
  • Modification sites at PhosphoSitePlus

Other Protein References for THRAP3 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for THRAP3 Gene

Domains for THRAP3 Gene

Protein Domains for THRAP3 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with THRAP3: view

No data available for Gene Families and UniProtKB/Swiss-Prot for THRAP3 Gene

Function for THRAP3 Gene

Molecular function for THRAP3 Gene

UniProtKB/Swiss-Prot Function: Involved in pre-mRNA splicing. Remains associated with spliced mRNA after splicing which probably involves interactions with the exon junction complex (EJC). Can trigger mRNA decay which seems to be independent of nonsense-mediated decay involving premature stop codons (PTC) recognition. May be involved in nuclear mRNA decay. Involved in regulation of signal-induced alternative splicing. During splicing of PTPRC/CD45 is proposed to sequester phosphorylated SFPQ from PTPRC/CD45 pre-mRNA in resting T-cells. Involved in cyclin-D1/CCND1 mRNA stability probably by acting as component of the SNARP complex which associates with both the 3end of the CCND1 gene and its mRNA. Involved in response to DNA damage. Is excluced from DNA damage sites in a manner that parallels transcription inhibition; the function may involve the SNARP complex. Initially thought to play a role in transcriptional coactivation through its association with the TRAP complex; however, it is not regarded as a stable Mediator complex subunit. Cooperatively with HELZ2, enhances the transcriptional activation mediated by PPARG, maybe through the stabilization of the PPARG binding to DNA in presence of ligand. May play a role in the terminal stage of adipocyte differentiation. Plays a role in the positive regulation of the circadian clock. Acts as a coactivator of the CLOCK-ARNTL/BMAL1 heterodimer and promotes its transcriptional activator activity and binding to circadian target genes (PubMed:24043798).

Gene Ontology (GO) - Molecular Function for THRAP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001046 core promoter sequence-specific DNA binding ISS --
GO:0001104 RNA polymerase II transcription cofactor activity IDA 10198638
GO:0003712 transcription cofactor activity IDA 12218053
GO:0003713 transcription coactivator activity IDA 12037571
GO:0004872 receptor activity IDA 12218053
genes like me logo Genes that share ontologies with THRAP3: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for THRAP3

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for THRAP3 Gene

Localization for THRAP3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for THRAP3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for THRAP3 Gene COMPARTMENTS Subcellular localization image for THRAP3 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for THRAP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 10235267
GO:0005654 nucleoplasm IDA --
GO:0016592 mediator complex IDA 10198638
GO:0035145 colocalizes_with exon-exon junction complex IDA 20123736
GO:0070062 extracellular exosome IDA 18570454
genes like me logo Genes that share ontologies with THRAP3: view

Pathways for THRAP3 Gene

SuperPathways for THRAP3 Gene

Superpath Contained pathways
1 PEDF Induced Signaling
genes like me logo Genes that share pathways with THRAP3: view

Pathways by source for THRAP3 Gene

1 Qiagen pathway for THRAP3 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for THRAP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000381 regulation of alternative mRNA splicing, via spliceosome IMP 20932480
GO:0000956 nuclear-transcribed mRNA catabolic process IDA 20123736
GO:0006367 transcription initiation from RNA polymerase II promoter IDA 12218053
GO:0006397 mRNA processing IEA --
GO:0008380 RNA splicing IEA --
genes like me logo Genes that share ontologies with THRAP3: view

Transcripts for THRAP3 Gene

Unigene Clusters for THRAP3 Gene

Thyroid hormone receptor associated protein 3:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for THRAP3

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for THRAP3

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for THRAP3 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16
SP1:
SP2:
SP3: - - -
SP4:
SP5:
SP6: - - - -
SP7: - -
SP8: -

Relevant External Links for THRAP3 Gene

GeneLoc Exon Structure for
THRAP3
ECgene alternative splicing isoforms for
THRAP3

Expression for THRAP3 Gene

mRNA expression in normal human tissues for THRAP3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for THRAP3 Gene

SOURCE GeneReport for Unigene cluster for THRAP3 Gene Hs.744057

mRNA Expression by UniProt/SwissProt for THRAP3 Gene

Q9Y2W1-TR150_HUMAN
Tissue specificity: Ubiquitous.
genes like me logo Genes that share expressions with THRAP3: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for THRAP3 Gene

Orthologs for THRAP3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for THRAP3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia THRAP3 35
  • 99.65 (n)
  • 100 (a)
THRAP3 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia THRAP3 35
  • 93.36 (n)
  • 97.22 (a)
THRAP3 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia THRAP3 35
  • 93.25 (n)
  • 96.66 (a)
THRAP3 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Thrap3 35
  • 89.24 (n)
  • 93.61 (a)
Thrap3 16
Thrap3 36
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 69 (a)
OneToMany
-- 36
  • 79 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia THRAP3 36
  • 88 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Thrap3 35
  • 89.46 (n)
  • 94.06 (a)
chicken
(Gallus gallus)
Aves THRAP3 35
  • 75.41 (n)
  • 79.75 (a)
THRAP3 36
  • 81 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia THRAP3 36
  • 72 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.7745 35
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC394509 35
thrap3 35
  • 63.29 (n)
  • 62.66 (a)
zebrafish
(Danio rerio)
Actinopterygii -- 35
BX321921.1 36
  • 39 (a)
OneToMany
thrap3a 36
  • 38 (a)
OneToMany
thrap3b 36
  • 40 (a)
OneToMany
Species with no ortholog for THRAP3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for THRAP3 Gene

ENSEMBL:
Gene Tree for THRAP3 (if available)
TreeFam:
Gene Tree for THRAP3 (if available)

Paralogs for THRAP3 Gene

Paralogs for THRAP3 Gene

Selected SIMAP similar genes for THRAP3 Gene using alignment to 6 proteins:

Pseudogenes.org Pseudogenes for THRAP3 Gene

genes like me logo Genes that share paralogs with THRAP3: view

Variants for THRAP3 Gene

Sequence variations from dbSNP and Humsavar for THRAP3 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs272813 -- 36,226,913(-) gttta(C/T)ttgct intron-variant
rs272814 -- 36,225,269(-) CCCAA(G/T)TAACA intron-variant
rs505661 -- 36,227,569(-) gcagt(A/G)gctta intron-variant
rs506930 -- 36,225,637(-) CAGGG(C/T)CATCT intron-variant
rs795048 -- 36,227,873(-) GTCCT(A/G)CCATG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for THRAP3 Gene

Variant ID Type Subtype PubMed ID
nsv834691 CNV Loss 17160897
dgv47e1 CNV Complex 17122850
nsv834702 CNV Loss 17160897
esv2544592 CNV Deletion 19546169
esv2045078 CNV Deletion 18987734
esv2746830 CNV Deletion 23290073
esv2663119 CNV Deletion 23128226
esv2746841 CNV Deletion 23290073
esv2125715 CNV Deletion 18987734
esv2746852 CNV Deletion 23290073
esv1002750 CNV Deletion 20482838
esv2746863 CNV Deletion 23290073
esv1414937 CNV Deletion 17803354
nsv160040 CNV Loss 16902084
nsv444 CNV Loss 18451855

Relevant External Links for THRAP3 Gene

HapMap Linkage Disequilibrium report
THRAP3
Human Gene Mutation Database (HGMD)
THRAP3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for THRAP3 Gene

Disorders for THRAP3 Gene

No disorders were found for THRAP3 Gene.

No data available for UniProtKB/Swiss-Prot for THRAP3 Gene

Publications for THRAP3 Gene

  1. Identity between TRAP and SMCC complexes indicates novel pathways for the function of nuclear receptors and diverse mammalian activators. (PMID: 10198638) Ito M. … Roeder R.G. (Mol. Cell 1999) 3 4
  2. Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry. (PMID: 15144186) Brill L.M. … Peters E.C. (Anal. Chem. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4
  5. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PMID: 16964243) Beausoleil S.A. … Gygi S.P. (Nat. Biotechnol. 2006) 3 4

Products for THRAP3 Gene

  • antibodies-online peptides for THRAP3
  • antibodies-online antibodies for THRAP3
  • antibodies-online kits for THRAP3

Sources for THRAP3 Gene

Back to Top

Content