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Aliases for THRAP3 Gene

Aliases for THRAP3 Gene

  • Thyroid Hormone Receptor Associated Protein 3 2 3 5
  • Thyroid Hormone Receptor-Associated Protein Complex 150 KDa Component 3 4
  • TRAP150 3 4
  • Thyroid Hormone Receptor-Associated Protein, 150 KDa Subunit 3

External Ids for THRAP3 Gene

Previous GeneCards Identifiers for THRAP3 Gene

  • GC01P036117
  • GC01P036359
  • GC01P036462
  • GC01P036690
  • GC01P034807

Summaries for THRAP3 Gene

GeneCards Summary for THRAP3 Gene

THRAP3 (Thyroid Hormone Receptor Associated Protein 3) is a Protein Coding gene. Among its related pathways are PEDF Induced Signaling. GO annotations related to this gene include poly(A) RNA binding and transcription coactivator activity. An important paralog of this gene is CXorf23.

UniProtKB/Swiss-Prot for THRAP3 Gene

  • Involved in pre-mRNA splicing. Remains associated with spliced mRNA after splicing which probably involves interactions with the exon junction complex (EJC). Can trigger mRNA decay which seems to be independent of nonsense-mediated decay involving premature stop codons (PTC) recognition. May be involved in nuclear mRNA decay. Involved in regulation of signal-induced alternative splicing. During splicing of PTPRC/CD45 is proposed to sequester phosphorylated SFPQ from PTPRC/CD45 pre-mRNA in resting T-cells. Involved in cyclin-D1/CCND1 mRNA stability probably by acting as component of the SNARP complex which associates with both the 3end of the CCND1 gene and its mRNA. Involved in response to DNA damage. Is excluced from DNA damage sites in a manner that parallels transcription inhibition; the function may involve the SNARP complex. Initially thought to play a role in transcriptional coactivation through its association with the TRAP complex; however, it is not regarded as a stable Mediator complex subunit. Cooperatively with HELZ2, enhances the transcriptional activation mediated by PPARG, maybe through the stabilization of the PPARG binding to DNA in presence of ligand. May play a role in the terminal stage of adipocyte differentiation. Plays a role in the positive regulation of the circadian clock. Acts as a coactivator of the CLOCK-ARNTL/BMAL1 heterodimer and promotes its transcriptional activator activity and binding to circadian target genes (PubMed:24043798).

Gene Wiki entry for THRAP3 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for THRAP3 Gene

Genomics for THRAP3 Gene

Regulatory Elements for THRAP3 Gene

Enhancers for THRAP3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around THRAP3 on UCSC Golden Path with GeneCards custom track

Promoters for THRAP3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around THRAP3 on UCSC Golden Path with GeneCards custom track

Genomic Location for THRAP3 Gene

Chromosome:
1
Start:
36,224,416 bp from pter
End:
36,305,357 bp from pter
Size:
80,942 bases
Orientation:
Plus strand

Genomic View for THRAP3 Gene

Genes around THRAP3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
THRAP3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for THRAP3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for THRAP3 Gene

Proteins for THRAP3 Gene

  • Protein details for THRAP3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y2W1-TR150_HUMAN
    Recommended name:
    Thyroid hormone receptor-associated protein 3
    Protein Accession:
    Q9Y2W1
    Secondary Accessions:
    • D3DPS5
    • Q5VTK6

    Protein attributes for THRAP3 Gene

    Size:
    955 amino acids
    Molecular mass:
    108666 Da
    Quaternary structure:
    • Associated with the large multiprotein complex TRAP (Mediator complex-like). Interacts with SFPQ; the interaction is dependent on SFPQ phosphorylation at Thr-687 and inhibits binding of SFPQ to an ESS1 exonic splicing silencer element-containing RNA. Interacts with NXF1. Component of the SNARP complex which consists at least of SNIP1, SNW1, THRAP3, BCLAF1 and PNN. Associated with spliced mRNP complexes. Interacts with HELZ2 and PPARG. Interacts with CLOCK and ARNTL/BMAL1 (By similarity). Component of the WTAP complex composed of WTAP, ZC3H13, CBLL1, KIAA1429, RBM15, BCLAF1 and THRAP3.
    SequenceCaution:
    • Sequence=AAH37554.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};

neXtProt entry for THRAP3 Gene

Proteomics data for THRAP3 Gene at MOPED

Post-translational modifications for THRAP3 Gene

  • ADP-ribosylation during genotoxic stress promotes accumulation in nuclear speckles.
  • Ubiquitination at Lys 221, Lys 470, Lys 519, and Lys 558
  • Modification sites at PhosphoSitePlus

Other Protein References for THRAP3 Gene

No data available for DME Specific Peptides for THRAP3 Gene

Domains & Families for THRAP3 Gene

Protein Domains for THRAP3 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with THRAP3: view

No data available for Gene Families and UniProtKB/Swiss-Prot for THRAP3 Gene

Function for THRAP3 Gene

Molecular function for THRAP3 Gene

UniProtKB/Swiss-Prot Function:
Involved in pre-mRNA splicing. Remains associated with spliced mRNA after splicing which probably involves interactions with the exon junction complex (EJC). Can trigger mRNA decay which seems to be independent of nonsense-mediated decay involving premature stop codons (PTC) recognition. May be involved in nuclear mRNA decay. Involved in regulation of signal-induced alternative splicing. During splicing of PTPRC/CD45 is proposed to sequester phosphorylated SFPQ from PTPRC/CD45 pre-mRNA in resting T-cells. Involved in cyclin-D1/CCND1 mRNA stability probably by acting as component of the SNARP complex which associates with both the 3end of the CCND1 gene and its mRNA. Involved in response to DNA damage. Is excluced from DNA damage sites in a manner that parallels transcription inhibition; the function may involve the SNARP complex. Initially thought to play a role in transcriptional coactivation through its association with the TRAP complex; however, it is not regarded as a stable Mediator complex subunit. Cooperatively with HELZ2, enhances the transcriptional activation mediated by PPARG, maybe through the stabilization of the PPARG binding to DNA in presence of ligand. May play a role in the terminal stage of adipocyte differentiation. Plays a role in the positive regulation of the circadian clock. Acts as a coactivator of the CLOCK-ARNTL/BMAL1 heterodimer and promotes its transcriptional activator activity and binding to circadian target genes (PubMed:24043798).

Gene Ontology (GO) - Molecular Function for THRAP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001046 core promoter sequence-specific DNA binding ISS --
GO:0001104 RNA polymerase II transcription cofactor activity IDA 10198638
GO:0042809 vitamin D receptor binding NAS 10235266
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with THRAP3: view
genes like me logo Genes that share phenotypes with THRAP3: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for THRAP3 Gene

Localization for THRAP3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for THRAP3 Gene

Nucleus. Nucleus, nucleoplasm. Nucleus speckle.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for THRAP3 Gene COMPARTMENTS Subcellular localization image for THRAP3 gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for THRAP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA 24100041
GO:0070062 extracellular exosome IDA 18570454
genes like me logo Genes that share ontologies with THRAP3: view

Pathways & Interactions for THRAP3 Gene

SuperPathways for THRAP3 Gene

Superpath Contained pathways
1 PEDF Induced Signaling
genes like me logo Genes that share pathways with THRAP3: view

Pathways by source for THRAP3 Gene

1 Qiagen pathway for THRAP3 Gene

SIGNOR curated interactions for THRAP3 Gene

Inactivates:

Gene Ontology (GO) - Biological Process for THRAP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006367 transcription initiation from RNA polymerase II promoter IDA 12218053
GO:0007623 circadian rhythm IEA --
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IDA 12037571
genes like me logo Genes that share ontologies with THRAP3: view

Drugs & Compounds for THRAP3 Gene

No Compound Related Data Available

Transcripts for THRAP3 Gene

Unigene Clusters for THRAP3 Gene

Thyroid hormone receptor associated protein 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for THRAP3 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16
SP1:
SP2:
SP3: - - -
SP4:
SP5:
SP6: - - - -
SP7: - -
SP8: -

Relevant External Links for THRAP3 Gene

GeneLoc Exon Structure for
THRAP3
ECgene alternative splicing isoforms for
THRAP3

Expression for THRAP3 Gene

mRNA expression in normal human tissues for THRAP3 Gene

Protein differential expression in normal tissues from HIPED for THRAP3 Gene

This gene is overexpressed in Nasal epithelium (14.3) and Peripheral blood mononuclear cells (12.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for THRAP3 Gene



SOURCE GeneReport for Unigene cluster for THRAP3 Gene Hs.744057

mRNA Expression by UniProt/SwissProt for THRAP3 Gene

Q9Y2W1-TR150_HUMAN
Tissue specificity: Ubiquitous.
genes like me logo Genes that share expression patterns with THRAP3: view

Protein tissue co-expression partners for THRAP3 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for THRAP3 Gene

Orthologs for THRAP3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for THRAP3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia THRAP3 35
  • 93.36 (n)
  • 97.22 (a)
THRAP3 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia THRAP3 35
  • 93.25 (n)
  • 96.66 (a)
THRAP3 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Thrap3 35
  • 89.24 (n)
  • 93.61 (a)
Thrap3 16
Thrap3 36
  • 93 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia THRAP3 35
  • 99.65 (n)
  • 100 (a)
THRAP3 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Thrap3 35
  • 89.46 (n)
  • 94.06 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 69 (a)
OneToMany
-- 36
  • 79 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia THRAP3 36
  • 88 (a)
OneToOne
chicken
(Gallus gallus)
Aves THRAP3 35
  • 75.41 (n)
  • 79.75 (a)
THRAP3 36
  • 81 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia THRAP3 36
  • 72 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC394509 35
thrap3 35
  • 63.29 (n)
  • 62.66 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.7745 35
zebrafish
(Danio rerio)
Actinopterygii -- 35
BX321921.1 36
  • 39 (a)
OneToMany
thrap3a 36
  • 38 (a)
OneToMany
thrap3b 36
  • 40 (a)
OneToMany
Species with no ortholog for THRAP3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for THRAP3 Gene

ENSEMBL:
Gene Tree for THRAP3 (if available)
TreeFam:
Gene Tree for THRAP3 (if available)

Paralogs for THRAP3 Gene

Paralogs for THRAP3 Gene

(1) SIMAP similar genes for THRAP3 Gene using alignment to 6 proteins:

Pseudogenes.org Pseudogenes for THRAP3 Gene

genes like me logo Genes that share paralogs with THRAP3: view

Variants for THRAP3 Gene

Sequence variations from dbSNP and Humsavar for THRAP3 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs6425977 - 36,286,832(+) TGAGG(C/T)CAAGG nc-transcript-variant, reference, missense, utr-variant-5-prime
rs272813 -- 36,226,913(-) gttta(C/T)ttgct intron-variant
rs272814 -- 36,225,269(-) CCCAA(G/T)TAACA intron-variant
rs505661 -- 36,227,569(-) gcagt(A/G)gctta intron-variant
rs506930 -- 36,225,637(-) CAGGG(C/T)CATCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for THRAP3 Gene

Variant ID Type Subtype PubMed ID
nsv834691 CNV Loss 17160897
dgv47e1 CNV Complex 17122850
nsv834702 CNV Loss 17160897
esv2544592 CNV Deletion 19546169
esv2045078 CNV Deletion 18987734
esv2746830 CNV Deletion 23290073
esv2663119 CNV Deletion 23128226
esv2746841 CNV Deletion 23290073
esv2125715 CNV Deletion 18987734
esv2746852 CNV Deletion 23290073
esv1002750 CNV Deletion 20482838
esv2746863 CNV Deletion 23290073
esv1414937 CNV Deletion 17803354
nsv160040 CNV Loss 16902084
nsv444 CNV Loss 18451855

Variation tolerance for THRAP3 Gene

Residual Variation Intolerance Score: 10% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.79; 47.39% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for THRAP3 Gene

Human Gene Mutation Database (HGMD)
THRAP3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for THRAP3 Gene

Disorders for THRAP3 Gene

Relevant External Links for THRAP3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
THRAP3

No disorders were found for THRAP3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for THRAP3 Gene

Publications for THRAP3 Gene

  1. A positive feedback loop links circadian clock factor CLOCK-BMAL1 to the basic transcriptional machinery. (PMID: 24043798) Lande-Diner L. … Weitz C.J. (Proc. Natl. Acad. Sci. U.S.A. 2013) 3 4 67
  2. Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes. (PMID: 25281560) Lambert J.P. … Gingras A.C. (J Proteomics 2015) 3
  3. Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes. (PMID: 25609649) Li X. … Chen J. (Mol. Syst. Biol. 2015) 3
  4. Luzp4 defines a new mRNA export pathway in cancer cells. (PMID: 25662211) Viphakone N. … Wilson S.A. (Nucleic Acids Res. 2015) 3
  5. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3

Products for THRAP3 Gene

Sources for THRAP3 Gene

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