Aliases for THRA Gene
- Thyroid Hormone Receptor, Alpha 2 3 5
- Thyroid Hormone Receptor, Alpha (Erythroblastic Leukemia Viral (V-Erb-A) Oncogene Homolog, Avian) 2 3
- Nuclear Receptor Subfamily 1 Group A Member 1 3 4
- V-ErbA-Related Protein 7 3 4
- C-ErbA-Alpha 3 4
- C-ERBA-1 3 4
- THRA1 3 4
- ERBA1 3 4
- THRA2 3 4
- EAR-7 3 4
- NR1A1 3 4
- EAR7 3 4
External Ids for THRA Gene
Previous HGNC Symbols for THRA Gene
Previous GeneCards Identifiers for THRA Gene
The protein encoded by this gene is a nuclear hormone receptor for triiodothyronine. It is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions of thyroid hormone. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
GeneCards Summary for THRA Gene
THRA (Thyroid Hormone Receptor, Alpha) is a Protein Coding gene. Diseases associated with THRA include Hypothyroidism, Congenital, Nongoitrous, 6 and Hypothyroidism, Congenital, Nongoitrous, 3. Among its related pathways are Transcription_Role of VDR in regulation of genes involved in osteoporosis and Development NOTCH1-mediated pathway for NF-KB activity modulation. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and transcription factor binding. An important paralog of this gene is THRB.
UniProtKB/Swiss-Prot for THRA Gene
Isoform Alpha-1: Nuclear hormone receptor that can act as a repressor or activator of transcription. High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine.
Isoform Alpha-2: Does not bind thyroid hormone and functions as a weak dominant negative inhibitor of thyroid hormone action.