THRA Gene
protein-coding GIFtS: 66
GCID: GC17P038219
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|
thyroid hormone receptor, alpha(Previous names: thyroid hormone receptor, alpha (avian erythroblastic leukemia...)
(Previous symbols: THRA1, THRA2, ERBA1)
| |
Aliases
for THRA gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Thyroid Hormone Receptor, Alpha1 2 | | V-ErbA-Related Protein 72 3 | | ERBA11 2 3 5 | | EAR-7.1/EAR-7.21 | | THRA11 2 3 5 | | THRA31 | | NR1A11 2 3 | | Thyroid Hormone Receptor, Alpha (Avian Erythroblastic Leukemia Viral (V-Erb-A)Oncogene Homolog)1 | | THRA21 2 3 | | CHNG62 | | AR71 2 | | ERB-T-12 | | ERBA1 2 | | C-ERBA-11 | | Thyroid Hormone Receptor, Alpha (Erythroblastic Leukemia Viral (V-Erb-A)Oncogene Homolog, Avian)1 2 | | ERBA-Related 72 | | Nuclear Receptor Subfamily 1 Group A Member 12 3 | | Thyroid Hormone Receptor Alpha2 | | EAR-72 3 | | Thyroid Normone Nuclear Receptor Alpha Variant 12 | | EAR72 3 | | Triiodothyronine Receptor2 | | C-ErbA-Alpha1 | | C-ErbA-11 |
Export aliases for THRA gene to outside databasesPrevious GC identifers: GC17P037816 GC17M040309 GC17P038129 GC17P038595 GC17P038596 GC17P035472 GC17P034012 |
Summaries
for THRA gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for THRA:
The protein encoded by this gene is a nuclear hormone receptor for triiodothyronine. It is one of the several receptorsfor thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies inmice suggest that the different receptors, while having certain extent of redundancy, may mediate different functionsof thyroid hormone. Alternatively spliced transcript variants encoding distinct isoforms have been reported. (providedby RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: THA_HUMAN, P10827Function: Nuclear hormone receptor. High affinity receptor for triiodothyronine
Gene Wiki entry for THRA (Thyroid hormone receptor alpha)
|
Genomic Views
for THRA gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000017.10 NC_018928.1 NT_010783.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the THRA gene promoter:
Sp1 AP-1 p300
Other transcription factors
Search SABiosciences Chromatin IP Primers for THRA
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat THRA |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 17q11.2 Ensembl cytogenetic band: 17q21.1 HGNC cytogenetic band: 17q21.1THRA Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17P038219: view genomic region
(about GC identifiers)
Start:
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38,214,543 bp from pter |
End:
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38,250,120 bp from pter |
Size:
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35,578 bases |
Orientation:
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plus strand |
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Proteins
for THRA gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: THA_HUMAN, P10827 (See
protein sequence)Recommended Name: Thyroid hormone receptor alpha Size: 490 amino acids; 54816 Da
Subunit: Interacts with NCOA3 and NCOA6 coactivators, leading to a strong increase of transcription of target genes.Probably interacts with SFPQ. Interacts with C1D (By similarity). Interacts with AKAP13. Interacts with TP53INP2
Subcellular location: Nucleus
6 PDB 3D structures from  and Proteopedia  for THRA:1NAV (3D)
2H77 (3D)
2H79 (3D)
3HZF (3D)
3ILZ (3D)
3JZB (3D)
Secondary accessions: A8K3B5 P21205 Q8N6A1 Q96H73Alternative splicing: 4 isoforms: P10827-1 P10827-2 P10827-3 P10827-4 Explore the universe of human proteins at neXtProt for THRA: NX_P10827
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P10827
THRA Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (4 alternative transcripts):
NP_001177847.1 NP_001177848.1 NP_003241.2 NP_955366.1
ENSEMBL proteins: ENSP00000464013 ENSP00000462955 ENSP00000464123 ENSP00000377679 ENSP00000463466 ENSP00000264637 ENSP00000395641 ENSP00000443972 ENSP00000464414 Reactome Protein details: P10827
Human Recombinant Protein Products for THRA:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table
THRA for ontologies About GeneDecksing
THRA Antibody Products:
Assay Products for THRA: |
Protein
Domains /
Families
for THRA gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
THRA for domains About GeneDecksing
5/6 InterPro domains/families (see all 6):Graphical View of Domain Structure for InterPro Entry P10827ProtoNet protein and cluster: P10827 2 Blocks protein families: IPB001723 Steroid hormone receptor signature IPB001728 Thyroid hormone receptor signature
UniProtKB/Swiss-Prot: THA_HUMAN, P10827Domain: Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-bindingdomainSimilarity: Belongs to the nuclear hormone receptor family. NR1 subfamilySimilarity: Contains 1 nuclear receptor DNA-binding domain |
Function
for THRA gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: THA_HUMAN, P10827Function: Nuclear hormone receptor. High affinity receptor for triiodothyronine Genatlas biochemistry entry for THRA:thyroid hormone receptor,alpha 1,ubiquitous,with two alternatively spliced isoforms THRA1,a hormone binding receptorand THRA2,not binding hormone but inhibiting THR transactivation,also encoding NR1D1 (alpha transcript) on theopposite strand (see symbol),steroid/thyroid hormone receptor superfamily
Gene Ontology (GO): 5/16 molecular function terms (GO ID links to tree view) (see all 16): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0002153 | steroid receptor RNA activator RNA binding |
IEA | -- | | GO:0003700 | sequence-specific DNA binding transcription factor activity |
IDA | 18052923 | | GO:0003707 | steroid hormone receptor activity |
IEA | -- | | GO:0003727 | single-stranded RNA binding |
-- | -- | | GO:0004879 | ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity |
-- | -- |
THRA for ontologies About GeneDecksing
Phenotypes:
2 GenomeRNAi human phenotypes for THRA:
15/23 MGI mutant phenotypes (inferred from 11 alleles ) (MGI details for Thra) (see all 23):
THRA for phenotypes About GeneDecksing
Animal Models:
Mouse knock-outs for THRA: Thratm3Jas Thratm1.1Fcas Thratm1Ven Thratm2Ven
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for THRA (see all 7)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for THRA (see all 3)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 4): THRA (NM_003250) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for THRA | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat THRA |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for THRA |
|
Pathways & Interactions
for THRA gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Transcription_Sin3 and NuRD in transcription regulation | | | 2 | Transcription_Role of VDR in regulation of genes involved in osteoporosis | | | 3 | Nuclear Receptor transcription pathway | | | 4 | Generic Transcription Pathway | | | 5 | Endochondral Ossification | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2 EMD Millipore Pathways for THRA
2  GeneGo (Thomson Reuters) Pathways for THRA
2  BioSystems Pathways for THRA
3 
Reactome Pathways for THRA
1 
Kegg Pathway (Kegg details for THRA):
THRA for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for THRA
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/109 Interacting proteins for THRA (P108271, 3 ENSP000002646374) via UniProtKB, MINT, STRING, and/or I2D (see all 109)About this table
Gene Ontology (GO): 5/25 biological process terms (GO ID links to tree view) (see all 25): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0001502 | cartilage condensation |
IEA | -- | | GO:0001503 | ossification |
IEA | -- | | GO:0002155 | regulation of thyroid hormone mediated signaling pathway |
IEA | -- | | GO:0006357 | regulation of transcription from RNA polymerase II promoter |
IDA | 18052923 | | GO:0006366 | transcription from RNA polymerase II promoter |
IDA | 8710870 |
THRA for ontologies About GeneDecksing
|
Drugs & Compounds
for THRA gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
THRA for compounds About GeneDecksing
 Browse Tocris compounds for THRA
1 HMDB Compound for THRA About this table
5 DrugBank Compounds for THRA About this table
10/11 Novoseek chemical compound relationships for THRA gene (see all 11) About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| triiodothyronine |
77.5 |
8 |
16832786 (2), 2158465 (1), 14596673 (1), 14656206 (1) (see all 7) |
| retinoic acid |
64.5 |
20 |
1347914 (1), 8253072 (1), 8455948 (1), 9727048 (1) (see all 14) |
| thyroxine |
48.6 |
1 |
14596673 (1) |
| estrogen |
25.3 |
8 |
11378852 (2), 9824153 (1), 11687272 (1), 19034372 (1) (see all 6) |
| vitamin d |
15.7 |
5 |
1850510 (1), 19034372 (1), 9287395 (1) |
| zinc |
13.5 |
3 |
11501753 (1), 1954886 (1), 11290385 (1) |
| oligonucleotide |
0 |
2 |
8062948 (1), 15585599 (1) |
| estradiol |
0 |
1 |
12624541 (1) |
| glucose |
0 |
1 |
19636322 (1) |
| progesterone |
0 |
2 |
12624541 (2) |
Search CenterWatch for drugs/clinical trials and news about THRA / THA
|
Transcripts
for THRA gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for THRA gene (4 alternative transcripts): NM_001190918.1 NM_001190919.1 NM_003250.5 NM_199334.3 Unigene Cluster for THRA: Thyroid hormone receptor, alpha Hs.724 [show with all ESTs]Unigene Representative Sequence: AB20934610 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000577288 ENST00000585047 ENST00000578218 ENST00000394121(uc021twy.1)
ENST00000584985(uc002htx.3) ENST00000264637(uc002htw.3) ENST00000450525(uc002htv.3)
ENST00000546243(uc010cwp.1) ENST00000577486 ENST00000577637
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for THRA (see all 7)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for THRA (see all 3)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 4): THRA (NM_003250) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for THRA | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat THRA |
Additional cDNA sequence: AB209346.1 AB307686.1 AF522368.1 AK290071.1 AK290530.1 AK311344.1 BC000261.1 BC002728.2 BC035137.1 BC062421.1 CR541915.1 HQ692859.1 J03239.1 M24899.1 M24900.1 X55005.1 Y00479.1 21 DOTS entries: DT.118297 DT.118299 DT.100807968 DT.95378840 DT.87015530 DT.95251994 DT.91758665 DT.75124373 DT.97847061 DT.91758657 DT.100740261 DT.99953623 DT.100031087 DT.120980017 DT.87015531 DT.91740668 DT.100665357 DT.100783912 DT.120980106 DT.91937029 DT.92036477 24/294 AceView cDNA sequences (see all 294): CA389910 BU737865 CR596083 BQ050643 AF522368 BC002728 CA454666 NM_003250 F02406 CR541915 BC000261 BC062421 AL043801 BG152611 AL047482 BQ672969 BQ529293 BM706074 F09846 BF197234 BM907134 BC035137 CD671434 BM700063
GeneLoc Exon Structure
|
Expression
for THRA gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| THRA expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TCTGTATCCC
About this image
See THRA Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for THRA
SOURCE GeneReport for Unigene cluster: Hs.724
SABiosciences Expression via Pathway-Focused PCR Array including THRA:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for THRA
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat THRA | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat THRA | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat THRA | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for THRA |
Orthologs
for THRA gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for THRA gene from 4/16 species (see all 16) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
THRA1 |
thyroid hormone receptor, alpha |
84.97(n)
90.44(a) |
|
396251 NM_205313.1 NP_990644.1 |
lizard
(Anolis carolinensis) |
Reptilia |
THRA6 |
-- |
85(a) |
1 ↔ 1 |
6(69290255-69322354) |
African clawed frog
(Xenopus laevis) |
Amphibia |
LOC3979422 |
Xenopus laevis thyroid hormone receptor alpha A mRNA, more |
84.62(n) |
|
M35343.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
thra2 |
thyroid hormone receptor alpha |
80.52(n) |
|
30670 NM_131396.1 |
ENSEMBL Gene Tree for THRA (if available)
TreeFam Gene Tree for THRA (if available) |
Paralogs
for THRA gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for THRA gene
- VDR2 NR4A32 NR4A12 NR1I22 RARG2 NR1I32 THRB2 RARA2
- NR1H22 NR4A22 NR1H42 RARB2 NR1H32
18/26 SIMAP similar genes for THRA using alignment to 6 protein entries: THA_HUMAN (see all proteins)
(see all similar genes):NR1A1 THRB NR1A2 HNF4G ESR1 NR3C2
HNF4alpha VDR NR1I3 NR1H3 BCOR-RARA NR1B3
RARA RARG PML-RAR ESRRA NR1B2 RARB
THRA for paralogs About GeneDecksing
|
Genomic Variants
for THRA gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 17 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for THRA (38214543 - 38250120 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for THRA: --
Human Gene Mutation Database (HGMD): THRA
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing THRA |
|
Disorders
/ Diseases
for THRA gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
THRA for disorders About GeneDecksing
OMIM gene information: 190120
OMIM disorders: --
UniProtKB/Swiss-Prot: THA_HUMAN, P10827
Defects in THRA are the cause of congenital hypothyroidism non-goitrous type 6 (CHNG6) [MIM:614450]. A diseasecharacterized by growth retardation, developmental retardation, skeletal dysplasia, borderline low thyroxine levelsand high triiodothyronine levels. There is differential sensitivity to thyroid hormone action, with retention ofhormone responsiveness in the hypothalamic pituitary axis and liver but skeletal, gastrointestinal, and myocardialresistance
20/37  diseases for THRA (see all 37): About MalaCardsthyroiditis glanzmann's thrombasthenia congenital diaphragmatic hernia leukemia
renal clear cell carcinoma thrombasthenia hyperthyroxinemia acute promyelocytic leukemia
coronary heart disease follicular thyroid carcinoma morbid obesity hernia
breast-ovarian cancer ovarian cancer dwarfism pituitary tumor
thyroid carcinoma liposarcoma thyroid cancer obesity
1 disease from the University of Copenhagen DISEASES database for THRA:Hypothyroidism 10/12 Novoseek disease relationships for THRA gene (see all 12) About this table
Genatlas disease: THRA hyperthyroxinemia,euthyroidal
Genetic Association Database (GAD): THRA
Human Genome Epidemiology (HuGE) Navigator: THRA (11 documents)
Tumor Gene Database (TGDB): THRA
Export disorders for THRA gene to outside databases
|
Publications
for THRA gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for THRA gene, integrated from 9 sources (see all 280):
(articles sorted by number of sources associating them with THRA) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Genomic organization of the human thyroid hormone receptor alpha (c- erbA-1) gene. (PubMed id 1850510)1, 2, 9 Laudet V....Saule S. (1991)
- Proteomic analysis of ubiquitinated proteins in normal hepatocyte cell line Chang liver cells. (PubMed id 18655026)1, 2 Tan F....Peng X. (2008)
- Thyroid cancer susceptibility and THRA1 and BAT-40 repeats polymorphisms. (PubMed id 15767343)1, 4 Baida A....Velazquez A. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- A nuclear factor ASC-2, as a cancer-amplified transcriptional coactivator essential for ligand-dependent transactivation by nuclear receptors in vivo. (PubMed id 10567404)1, 2 Lee S.-K.... Lee J.W. (1999)
- Characterization of Brx, a novel Dbl family member that modulates estrogen receptor action. (PubMed id 9627117)1, 2 Rubino D.... Segars J. (1998)
- Nuclear receptor coactivator ACTR is a novel histone acetyltransferase and forms a multimeric activation complex with P/CAF and CBP/p300. (PubMed id 9267036)1, 2 Chen H.... Evans R.M. (1997)
- Two erbA homologs encoding proteins with different T3 binding capacities are transcribed from opposite DNA strands of the same genetic locus. (PubMed id 2539258)1, 2 Miyajima N.... Yamamoto T. (1989)
- Characterization of a third human thyroid hormone receptor coexpressed with other thyroid hormone receptors in several tissues. (PubMed id 2464749)1, 2 Nakai A.... Degroot L.J. (1988)
- Characterization of a thyroid hormone receptor expressed in human kidney and other tissues. (PubMed id 3357890)1, 2 Nakai A.... Degroot L.J. (1988)
|
External Searches for THRA gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing THRA gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing THRA gene
(According to HUGE)
About This Section
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Specialized Databases showing THRA gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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| Patent Information for THRA gene:
Search GeneIP for patents involving THRA
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for THRA gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
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| | |  | OriGene Antibodies for THRA | | OriGene shRNA RFP for THRA | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for THRA | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for THRA | | | OriGene Protein Over-expression Lysate for THRA | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for THRA | | OriGene 3'-UTR Clone for THRA | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for THRA | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for THRA | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for THRA | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for THRA | | OriGene Custom Protein Services for THRA | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat THRA | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing THRA | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat THRA | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat THRA | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat THRA | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat THRA |
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| | | | Search Tocris compounds for THRA |
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 | | | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for THRA |
|  |  |  |  | | | | ThermoFisher Antibody for THRA |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat THRA |
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