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THRA Gene

protein-coding GIFtS: 66

GC17P035472

thyroid hormone receptor, alpha (erythroblastic leukemia viral (v-erb-a) oncogene homolog, avian)
(Previous names: thyroid hormone receptor, alpha (avian erythroblastic leukemia viral (v-erb-a) oncogene homolog) )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbols: THRA1, THRA2, ERBA1)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
AR7 ^¹, ²
C-erbA-alpha ^³
EAR-7 ^³
EAR-7.1/EAR-7.2 ^¹
EAR7 ^², ³
ERB-T-1 ^²
ERBA ^¹, ²
ERBA1 ^², ³, ⁵
MGC000261 ^²
MGC43240 ^²
NR1A1 ^¹, ², ³
OTTHUMP00000164470 ^²
THRA1 ^², ³, ⁵
THRA2 ^², ³
THRA3 ^¹
c-ERBA-1 ^²
c-erbA-1 ^³

Descriptions
ERBA-related 7 ^²
Nuclear receptor subfamily 1 group A member 1 ^³
avian erythroblastic leukemia viral (v-erb-a) oncogene homolog ^²
thyroid hormone receptor alpha ^²
thyroid hormone receptor, alpha ^²
thyroid hormone receptor, alpha (avian erythroblastic leukemia viral (v-erb-a) oncogene homolog) ^¹
thyroid hormone receptor, alpha (erythroblastic leukemia viral (v-erb-a) oncogene homolog, avian) ^²
triiodothyronine receptor ^²

External Ids
HGNC: 11796¹
Entrez Gene: 7067²
UniProtKB: P10827³
Ensembl: ENSG00000126351⁷

Search outside databases for aliases for THRA gene

Previous GC identifers: GC17P037816 GC17M040309 GC17P038129 GC17P038595 GC17P038596

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for THRA:

The protein encoded by this gene is a nuclear hormone receptor for triiodothyronine. It is one of

the several receptors for thyroid hormone, and has been shown to mediate the biological activities

of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having

certain extent of redundancy, may mediate different functions of thyroid hormone. Alternatively

spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq]

UniProtKB/Swiss-Prot: THA_HUMAN, P10827

Function: Nuclear hormone receptor. High affinity receptor for triiodothyronine

Gene Wiki entry for THRA (Thyroid_hormone_receptor_alpha)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the THRA gene

Entrez Gene cytogenetic band: 17q11.2 Ensembl cytogenetic band: 17q21.1 HGNC cytogenetic band: 17q21.1

THRA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 17 GeneLoc Exon Structure

GeneLoc location for GC17P035472: (about GC identifiers)

Start:	35,472,589 bp from pter
End:	35,503,646 bp from pter
Size:	31,058 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000017.9 NT_010755.15

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: THA_HUMAN, P10827 (See protein sequence)

Recommended Name: Thyroid hormone receptor alpha

Size: 490 amino acids; 54816 Da

Subunit: Interacts with NCOA3 and NCOA6 coactivators, leading to a strong increase of transcription

of target genes. Probably interacts with SFPQ. Interacts with C1D (By similarity). Interacts with

AKAP13

Subcellular location: Nucleus

PDB structure from and Proteopedia :

1NAV (3D)

2H79 (3D)

Secondary accessions: P21205 Q8N6A1 Q96H73

Alternative splicing: 4 isoforms: P10827-1 P10827-2 P10827-3 P10827-4

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (2 alternative transcripts):

NP_003241.2 NP_955366.1

ENSEMBL proteins:

ENSP00000264637 ENSP00000377679

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Thyroid Hormone Receptor alpha 2, Thyroid Hormone Receptor, Thyroid Hormone Receptor alpha 1+2, Thyroid Hormone Receptor alpha 1)
	Human Recombinant Proteins from Abnova (THRA)

OriGene Purified Recombinant Human Protein: THRA

1 Gene Ontology (GO) cellular component term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--

About this table

Antibodies for THRA:

	Invitrogen Antibodies for THRA
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for THRA
	R&D Systems Antibodies for THRA (TR alpha/NR1A1)
	Antibodies from Abcam (Thyroid Hormone Receptor alpha 2, Thyroid Hormone Receptor, Thyroid Hormone Receptor alpha 1+2, Thyroid Hormone Receptor alpha 1), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (THRA)
	Novus Biologicals Antibodies for THRA

Assays for THRA:

	Invitrogen Assays for THRA
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P10827

ProtoNet protein and cluster: P10827

2 Blocks protein families:

IPB001723 Steroid hormone receptor signature

IPB001728 Thyroid hormone receptor signature

UniProtKB/Swiss-Prot: THA_HUMAN, P10827

Domain: Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a

C-terminal steroid-binding domain

Similarity: Belongs to the nuclear hormone receptor family. NR1 subfamily

Similarity: Contains 1 nuclear receptor DNA-binding domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (THRA)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (THRA)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_003250

Applied Biosystems Silencer® siRNAs for THRA

Sigma-Aldrich siRNA and siRNA Panels for THRA

Sigma-Aldrich shRNA Panels and shRNA for THRA

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for THRA
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_003250
Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_003250
untagged cDNA clones in CMV expression vector (see all 3): NM_003250

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_003250

UniProtKB/Swiss-Prot: THA_HUMAN, P10827

Function: Nuclear hormone receptor. High affinity receptor for triiodothyronine

Genatlas biochemistry entry for THRA:

thyroid hormone receptor,alpha 1,ubiquitous,with two alternatively spliced isoforms THRA1,a hormone

binding receptor and THRA2,not binding hormone but inhibiting THR transactivation,also encoding

NR1D1 (alpha transcript) on the opposite strand (see symbol),steroid/thyroid hormone receptor

superfamily

15/21 MGI mutant phenotypes (inferred from 9 alleles) (MGI details for Thra) (see all 21 ):

	adipose tissue	behavior/neurological	craniofacial	digestive/alimentary
endocrine/exocrine gland	growth/size	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism
immune system	lethality-postnatal	lethality-prenatal/perinatal	life span-post-weaning/aging	limbs/digits/tail

5/7 Gene Ontology (GO) molecular function terms (links to tree view) (see all 7 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003700	transcription factor activity	TAS	2879242
GO:0003707	steroid hormone receptor activity	IEA	--
GO:0004887	thyroid hormone receptor activity	TAS	8806651
GO:0005515	protein binding	IPI	10866662 16799563
GO:0008270	zinc ion binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

1 Sigma-Aldrich "Your Favorite Gene" Pathway for THRA (Your Favorite Gene powered by Ingenuity)

TR/RXR Activation

GeneDecks THRA for the pathways selected above

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Gene Network Central^TM Interacting Genes and Proteins Network for THRA

5/50 Interacting proteins for THRA (ENSP00000264637³ P10827¹) via UniProtKB, MINT, and/or STRING (see all 50 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
MED1	Q15648¹	STRING (score=.972) EBI-286285, EBI-394459
Ncoa6 Ncoa6 (xeno)	Q9JLI4¹	EBI-286285, EBI-286271
NCOA1	ENSP00000320940³	STRING (score=.99)
NCOR2	ENSP00000348551³	STRING (score=.988)
NCOA6	ENSP00000351894³	STRING (score=.982)

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2 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006355	regulation of transcription, DNA-dependent	IEA	--
GO:0006366	transcription from RNA polymerase II promoter	TAS	2879242

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Sigma-Aldrich Small Molecules for THRA:

Antagonist Inhibitor

Browse Tocris compounds for THRA
6 Novoseek chemical compound relationships for THRA gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
triiodothyronine	77.52	8	16832786 (2), 2158465 (1), 14596673 (1), 14656206 (1) (see all 7)
zinc	15.96	3	11501753 (1), 1954886 (1), 11290385 (1)
estradiol	0.00	1	12624541 (1)
oligonucleotide	0.00	2	8062948 (1), 15585599 (1)
progesterone	0.00	2	12624541 (2)
tyrosine	0.00	1	1347913 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (THRA)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (THRA)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_003250

Sigma-Aldrich siRNA and siRNA Panels for THRA

Sigma-Aldrich shRNA Panels and shRNA for THRA

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_003250 NM_199334

REFSEQ mRNAs for THRA gene (2 alternative transcripts):

NM_003250.4 NM_199334.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_003250 NM_199334

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_003250
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_003250
                                 untagged cDNA clones in CMV expression vector (see all 3): NM_003250

Additional cDNA sequence:

AB209346.1 AB307686.1 AF522368.1 AK290071.1 AK290530.1 AK311344.1 BC000261.1 BC002728.2

BC008851.2 BC035137.1 BC062421.1 CR541915.1 CR596083.1 CR602782.1 J03239.1 M24899.1

M24900.1 X55005.1 Y00479.1

21 DOTS entries:

DT.118297 DT.118299 DT.100807968 DT.95378840 DT.87015530 DT.95251994 DT.91758665 DT.75124373

DT.97847061 DT.91758657 DT.100740261 DT.99953623 DT.100031087 DT.120980017 DT.87015531 DT.91740668

DT.100665357 DT.100783912 DT.120980106 DT.91937029 DT.92036477

24/294 AceView cDNA sequences (see all 294 ):

AL047482 BG152611 AL043752 BM706074 BU737664 BC035137 BQ672969 BU730463

BX279655 BF941812 CA433614 AI391498 NM_199334 BC062421 CD671434 CA454666

AL043801 AI418035 F02406 BC002728 BQ050643 BQ529293 BM694559 BM907134

highest scoring ESTs for THRA:

M24899 AL541718 AL550681 AL566445 AL567981 BF344977 BF346358 BG339926 BG911210 BI602714

Unigene Cluster for THRA:

Thyroid hormone receptor, alpha (erythroblastic leukemia viral (v-erb-a) oncogene homolog, avian)

Hs.724 [show with all ESTs]

Unigene Representative Sequence: AB209346

GeneLoc Exon Structure

2 Ensembl transcripts including schematic representations:

ENST00000264637 ENST00000394121

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

THRA expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for THRA

¹ / ² / ³

12 probe-sets matching THRA gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
35846_at²^{, 3}	U133-A	1	1.00	1.00	0.93	0.97	M24899	1.00	0.90	0.95	1
1316_at²^{, 3}	U133-A	1	1.00	1.00	0.03	0.71	X55005	0.80	0.80	0.80	1
616_s_at²^{, 3}	U95-A	1	1.00	1.00	0.91	0.90	M24748	0.20	1.00	0.72	1
86815_at²^{, 3}	U95-E	1	1.00	1.00	0.73	1.45	AI144477	0.60	1.00	0.82	1
35846_at²^{, 3}	U133-A	1	1.00	1.00	--	--	M24899	1.00	0.90	0.95	1
1316_at²^{, 3}	U133-A	1	1.00	1.00	--	--	X55005	0.80	0.80	0.80	1
204100_at²^{, 3}	U133-A	2	1.00	0.82	--	--	NM_003250	0.60	1.00	0.82	1
214883_at²^{, 3}	U133-A	1	0.64	1.00	--	--	X55005	0.80	0.80	0.80	1
35846_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
1316_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
204100_at²	U133Plus2	2	1.00	0.82	--	--	--	--	--	--	--
214883_at²	U133Plus2	1	0.64	1.00	--	--	--	--	--	--	--

GeneDecks THRA for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: TCTGTATCCC

SOURCE GeneReport for Unigene cluster: Hs.724
Expression variation in blood from EXPOLDB for THRA

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for THRA gene from 5/8 species (see all 8 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	THRA¹	--	thyroid hormone receptor, alpha (erythroblastic leukemia more	96.69(n) 98.55(a)	403601 XM_846074.1 XP_851167.1
cow (Bos taurus)	THRA¹	--	thyroid hormone receptor, alpha (erythroblastic leukemia more	96.49(n) 97.93(a)	532621 NM_001046329.1 NP_001039794.1
rat (Rattus norvegicus)	Thra¹	--	thyroid hormone receptor alpha	95.65(n) 97.55(a)	81812 NM_031134.2 NP_112396.2
mouse (Mus musculus)	Thra^{1, 5}	11 (57.00 cM)⁵	thyroid hormone receptor alpha^{1, 5}	94.93(n)¹ 97.87(a)¹	21833¹ NM_178060.3¹ NP_835161.1¹ AI841022⁵ AK078233⁵ (see all 16)
zebrafish (Danio rerio)	thra²	--	thyroid hormone receptor alpha	80.52(n)	30670 NM_131396.1

About this table Species with no ortholog for THRA

ENSEMBL Gene Tree for THRA

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for THRA gene

VDR² NR1I2² NR1I3² THRB²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/134 NCBI SNPs in THRA are shown (see all 134 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 69)

AB	SNP ID	Valid	Chr 17 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs939345^1,2	A,C,H	35470876(-)	`CTTGGG/AATTGG`	2	--	ng5¹ tfbs³		4		EU EA WA	418
	rs12939700^1,2	C,F,H	35499317(+)	`GAGACC/ACCCCC`	2	--	int¹ ut3¹		4		EU EA WA	384
--	rs7502233^1,2	A,C	35472330(+)	`AAGGTA/GCAGGC`	2	--	ng5¹		0	--	--	--	--
--	rs7502539^1,2	C	35472531(+)	`gccggA/Gcctct`	2	--	ng5¹		0	--	--	--	--
	rs2230701^1,2	C,F,H	35493742(+)	`ATCGCC/TGTGGG`	2	A/A	syn¹		9		MN NA EU EA WA	670
--	rs2230702^1,2	C,F	35496629(+)	`TTCTCC/TGAGGT`	2	S/S	syn¹		3		MN NA	190
	rs8078399^1,2	A,C,F,H	35478024(+)	`CAATGG/TTTCCT`	2	--	int¹		8		EU EA WA	836
--	rs7217037^1,2	A,C,F,H	35476717(+)	`AGTGCT/CTAGTT`	2	--	int¹		3		EU EA	300
	rs3923377^1,2	A,C,F,H	35476929(-)	`ACACTA/CATTCC`	2	--	int¹		3		EU EA	300
--	rs7217291^1,2	A,C,F,H	35476521(+)	`CAGCTA/GAGAAC`	2	--	int¹		3		EU EA	300

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HapMap Linkage Disequilibrium images for THRA (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 190120

10/11 Novoseek disease relationships for THRA gene (see all 11 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
osteoclastoma	60.24	2	10807056 (2)
erythroleukemia	32.26	1	11420726 (1)
thyroid cancer	18.55	4	12231529 (4)
hypertrophy	11.66	2	15831522 (1)
tumors	0.36	11	10487522 (3), 12231529 (2), 10022432 (1), 10822129 (1) (see all 7)
cancer	0.00	5	11889175 (2), 12668276 (1), 12231529 (1), 15650025 (1)
breast cancer	0.00	3	16832786 (2), 9695977 (1)
metastasis	0.00	1	11741739 (1)
ovarian cancer	0.00	1	8460637 (1)
nsclc	0.00	1	12911822 (1)

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Genatlas disease: THRA

hyperthyroxinemia,euthyroidal

Genetic Association Database: THRA
Human Genome Epidemiology Navigator: THRA (4 documents)
Tumor Gene Database: THRA
Breast Cancer Gene Database: THRA

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/209 PubMed articles for THRA gene (see all 209 ):

Genomic organization of the human thyroid hormone receptor alpha (c- erbA-1) gene. (PubMed id 1850510)^{1, 3, 4} Laudet V....Saule S. (1991)
Thyroid cancer susceptibility and THRA1 and BAT-40 repeats polymorphisms. (PubMed id 15767343)^{3, 6} Baida A....Velazquez A. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
A nuclear factor ASC-2, as a cancer-amplified transcriptional coactivator essential for ligand-dependent transactivation by nuclear receptors in vivo. (PubMed id 10567404)^{3, 4} Lee S.-K.... Lee J.W. (1999)
Characterization of Brx, a novel Dbl family member that modulates estrogen receptor action. (PubMed id 9627117)^{3, 4} Rubino D.... Segars J. (1998)
Nuclear receptor coactivator ACTR is a novel histone acetyltransferase and forms a multimeric activation complex with P/CAF and CBP/p300. (PubMed id 9267036)^{3, 4} Chen H.... Evans R.M. (1997)
Two erbA homologs encoding proteins with different T3 binding capacities are transcribed from opposite DNA strands of the same genetic locus. (PubMed id 2539258)^{3, 4} Miyajima N.... Yamamoto T. (1989)
Characterization of a third human thyroid hormone receptor coexpressed with other thyroid hormone receptors in several tissues. (PubMed id 2464749)^{3, 4} Nakai A.... Degroot L.J. (1988)
Characterization of a thyroid hormone receptor expressed in human kidney and other tissues. (PubMed id 3357890)^{3, 4} Nakai A.... Degroot L.J. (1988)
A novel thyroid hormone receptor encoded by a cDNA clone from a human testis library. (PubMed id 3672126)^{3, 4} Benbrook D. and Pfahl M. (1987)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 7067	HGNC: 11796	AceView: THRA	Ensembl:ENSG00000126351	euGenes: HUgn7067
ECgene: THRA	H-InvDB: THRA

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for THRA	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for THRA
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for THRA:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
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Antibodies for THRA

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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THRA Gene at Home site.
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THRA Gene

protein-coding GIFtS: 66

Aliases &
Descriptions
for THRA

Summaries
for THRA

Genomic Location
for THRA

Proteins
for THRA

Protein Domains/
Families
for THRA

Gene Function
for THRA

Pathways & Interactions
for THRA

Drugs & Compounds
for THRA

Transcripts
for THRA

Expression
for THRA

Orthologs
for THRA

Paralogs
for THRA

SNPs/Variants
for THRA

Disorders & Mutations
for THRA

Medical News
for THRA

Publications
for THRA

Search for THRA

Genome Databases showing THRA

Other Databases showing THRA

Specialized Databases showing THRA

Licensable Technologies
for THRA

Services
for THRA

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

THRA (Gene Symbol)
AR7
C-erbA-alpha
EAR-7
EAR-7.1/EAR-7.2
EAR7
ERB-T-1
ERBA
ERBA1
MGC000261
MGC43240
NR1A1
OTTHUMP00000164470
THRA1
THRA2
THRA3
c-ERBA-1
c-erbA-1
ERBA-related 7
Nuclear receptor subfamily 1 group A member 1
avian erythroblastic leukemia viral (v-erb-a) oncogene homolog
thyroid hormone receptor alpha
thyroid hormone receptor, alpha
thyroid hormone receptor, alpha (avian erythroblastic leukemia viral (v-erb-a) oncogene homolog)
thyroid hormone receptor, alpha (erythroblastic leukemia viral (v-erb-a) oncogene homolog, avian)
triiodothyronine receptor

THRA Gene

protein-coding GIFtS: 66

Aliases & Descriptionsfor THRA

Summariesfor THRA

Genomic Locationfor THRA

Proteinsfor THRA

Protein Domains/Familiesfor THRA

Gene Functionfor THRA

Pathways & Interactionsfor THRA

Drugs & Compoundsfor THRA

Transcriptsfor THRA

Expression for THRA

Orthologsfor THRA

Paralogsfor THRA

SNPs/Variantsfor THRA

Disorders & Mutationsfor THRA

Medical Newsfor THRA

Publicationsfor THRA

Search for THRA

Genome Databases showing THRA

Other Databases showing THRA

Specialized Databases showing THRA

Licensable Technologiesfor THRA

Servicesfor THRA

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for THRA

Summaries
for THRA

Genomic Location
for THRA

Proteins
for THRA

Protein Domains/
Families
for THRA

Gene Function
for THRA

Pathways & Interactions
for THRA

Drugs & Compounds
for THRA

Transcripts
for THRA

Expression
for THRA

Orthologs
for THRA

Paralogs
for THRA

SNPs/Variants
for THRA

Disorders & Mutations
for THRA

Medical News
for THRA

Publications
for THRA

Licensable Technologies
for THRA

Services
for THRA