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THRA Gene

protein-coding   GIFtS: 69
GCID: GC17P038219

Thyroid Hormone Receptor, Alpha

(Previous names: thyroid hormone receptor, alpha (avian erythroblastic leukemia...)
(Previous symbols: THRA1, THRA2, ERBA1)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Thyroid Hormone Receptor, Alpha1 2     CHNG62 5
ERBA11 2 3 5     Thyroid Hormone Receptor, Alpha (Avian Erythroblastic Leukemia Viral
(V-Erb-A) Oncogene Homolog)1
THRA11 2 3 5     AR72
THRA21 2 3     ERB-T-12
Thyroid Hormone Receptor, Alpha (Erythroblastic Leukemia Viral (V-Erb-A)
Oncogene Homolog, Avian)1 2
     ERBA2
Nuclear Receptor Subfamily 1 Group A Member 12 3     c-ERBA-12
EAR-72 3     ERBA-Related 72
EAR72 3     Thyroid Hormone Receptor Alpha2
NR1A12 3     Thyroid Normone Nuclear Receptor Alpha Variant 12
c-erbA-alpha2 3     Triiodothyronine Receptor2
V-ErbA-Related Protein 72 3     c-erbA-13

External Ids:    HGNC: 117961   Entrez Gene: 70672   Ensembl: ENSG000001263517   OMIM: 1901205   UniProtKB: P108273   

Export aliases for THRA gene to outside databases

Previous GC identifers: GC17P037816 GC17M040309 GC17P038129 GC17P038595 GC17P038596 GC17P035472 GC17P034012


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for THRA Gene:
The protein encoded by this gene is a nuclear hormone receptor for triiodothyronine. It is one of the several
receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone.
Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may
mediate different functions of thyroid hormone. Alternatively spliced transcript variants encoding distinct
isoforms have been reported. (provided by RefSeq, Jul 2008)

GeneCards Summary for THRA Gene:
THRA (thyroid hormone receptor, alpha) is a protein-coding gene. Diseases associated with THRA include hypothyroidism, congenital, nongoitrous, 6, and hyperthyroxinemia. GO annotations related to this gene include transcription factor binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is VDR.

UniProtKB/Swiss-Prot: THA_HUMAN, P10827
Function: Nuclear hormone receptor that can act as a repressor or activator of transcription. High affinity
receptor for thyroid hormones, including triiodothyronine and thyroxine

Gene Wiki entry for THRA (Thyroid hormone receptor alpha) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000017.11  NC_018928.2  NT_010783.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the THRA gene promoter:
         Sp1   AP-1   p300   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 4): THRA promoter sequence
   Search Chromatin IP Primers for THRA

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat THRA


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q11.2   Ensembl cytogenetic band:  17q21.1   HGNC cytogenetic band: 17q21.1

THRA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
THRA gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P038219:  view genomic region     (about GC identifiers)

Start:
38,214,543 bp from pter      End:
38,250,120 bp from pter
Size:
35,578 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: THA_HUMAN, P10827 (See protein sequence)
Recommended Name: Thyroid hormone receptor alpha  
Size: 490 amino acids; 54816 Da
Subunit: Binds DNA as a dimer; homodimer and heterodimer with RXRB. Interacts with NCOA3 and NCOA6 coactivators,
leading to a strong increase of transcription of target genes. Probably interacts with SFPQ. Interacts with C1D
(By similarity). Interacts with AKAP13. Interacts with TP53INP2
6 PDB 3D structures from and Proteopedia for THRA:
1NAV (3D)        2H77 (3D)        2H79 (3D)        3HZF (3D)        3ILZ (3D)        3JZB (3D)    
Secondary accessions: A8K3B5 P21205 Q8N6A1 Q96H73
Alternative splicing: 4 isoforms:  P10827-1   P10827-2   P10827-3   P10827-4   

Explore the universe of human proteins at neXtProt for THRA: NX_P10827

Explore proteomics data for THRA at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys190
  • Modification sites at PhosphoSitePlus

  • See THRA Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001177847.1  NP_001177848.1  NP_003241.2  NP_955366.1  

    ENSEMBL proteins: 
     ENSP00000464013   ENSP00000462955   ENSP00000464123   ENSP00000377679   ENSP00000463466  
     ENSP00000264637   ENSP00000395641   ENSP00000443972   ENSP00000464414  
    Reactome Protein details: P10827

    THRA Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins for THRA
    OriGene Protein Over-expression Lysate for THRA
    OriGene MassSpec for THRA
    OriGene Custom Protein Services for THRA
    GenScript Custom Purified and Recombinant Proteins Services for THRA
    Novus Biologicals THRA Proteins
    Novus Biologicals THRA Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

    THRA Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for THRA (TR alpha/NR1A1)
    OriGene Antibodies for THRA
    OriGene Custom Antibody Services for THRA
    Novus Biologicals THRA Antibodies
    Abcam antibodies for THRA (P10827, P10828)
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibody for THRA
    LSBio Antibodies in human, mouse, rat for THRA

    THRA Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for THRA
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    NR: Nuclear hormone receptors

    IUPHAR Guide to PHARMACOLOGY protein family classification: Thyroid hormone receptor-alpha
    1A. Thyroid Hormone Receptors

    Selected InterPro protein domains (see all 6):
     IPR013088 Znf_NHR/GATA
     IPR008946 Nucl_hormone_rcpt_ligand-bd
     IPR000536 Nucl_hrmn_rcpt_lig-bd_core
     IPR001628 Znf_hrmn_rcpt
     IPR001723 Str_hrmn_rcpt

    Graphical View of Domain Structure for InterPro Entry P10827

    ProtoNet protein and cluster: P10827

    2 Blocks protein domains:
    IPB001723 Steroid hormone receptor signature
    IPB001728 Thyroid hormone receptor signature


    UniProtKB/Swiss-Prot: THA_HUMAN, P10827
    Domain: Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal
    ligand-binding domain
    Similarity: Belongs to the nuclear hormone receptor family. NR1 subfamily
    Similarity: Contains 1 nuclear receptor DNA-binding domain


    THRA for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: THA_HUMAN, P10827
    Function: Nuclear hormone receptor that can act as a repressor or activator of transcription. High affinity
    receptor for thyroid hormones, including triiodothyronine and thyroxine

         Genatlas biochemistry entry for THRA:
    thyroid hormone receptor,alpha 1,ubiquitous,with two alternatively spliced isoforms THRA1,a hormone binding
    receptor and THRA2,not binding hormone but inhibiting THR transactivation,also encoding NR1D1 (alpha transcript)
    on the opposite strand (see symbol),steroid/thyroid hormone receptor superfamily

         Gene Ontology (GO): Selected molecular function terms (see all 16):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002153steroid receptor RNA activator RNA binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity IDA18052923
    GO:0003707steroid hormone receptor activity IEA--
    GO:0003727single-stranded RNA binding ----
    GO:0004879ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity ----
         
    THRA for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for THRA:
     Decreased G3BP1 protein expres  Synthetic lethal with Ras 

         Selected MGI mutant phenotypes (inferred from 11 alleles(MGI details for Thra) (see all 23):
     adipose tissue  behavior/neurological  cardiovascular system  cellular  craniofacial 
     digestive/alimentary  endocrine/exocrine gland  growth/size/body  hearing/vestibular/ear  hematopoietic system 
     homeostasis/metabolism  immune system  integument  limbs/digits/tail  liver/biliary system 

    THRA for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for THRA: Thratm3Jas Thratm1.1Fcas Thratm1Ven Thratm2Ven

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for THRA
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for THRA

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for THRA
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for THRA

    Transcription Factor Targeting: 
    Targeting motifs: HOMER Transcription Factor Regulatory Elements motif viewer 
                                          Consensus sequence:  GGTCANYTGAGGWCA 

    miRNA
    Products:
        
    miRTarBase miRNAs that target THRA:
    hsa-mir-877-5p (MIRT037281), hsa-mir-18a-5p (MIRT004386), hsa-mir-375 (MIRT019902), hsa-mir-15b-5p (MIRT046501), hsa-mir-330-3p (MIRT043845)

    Block miRNA regulation of human, mouse, rat THRA using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate THRA (see all 54):
    hsa-miR-549 hsa-miR-106a hsa-miR-4272 hsa-miR-765 hsa-miR-128 hsa-miR-138-2* hsa-miR-519a hsa-miR-4267
    SwitchGear 3'UTR luciferase reporter plasmidTHRA 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for THRA
    Predesigned siRNA for gene silencing in human, mouse, rat THRA

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for THRA

    Clone
    Products:
         
    OriGene clones in human, mouse for THRA (see all 16)
    OriGene ORF clones in mouse, rat for THRA
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 4): THRA (NM_003250)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for THRA
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat THRA

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for THRA
    Browse ESI BIO Cell Lines and PureStem Progenitors for THRA 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for THRA


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    THA_HUMAN, P10827: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol5
    nucleus5
    peroxisome1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA19158403
    GO:0005654nucleoplasm TAS--
    GO:0005737cytoplasm ----
    GO:0005829cytosol IDA19158403

    THRA for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for THRA About   (see all 7)  
    See pathways by source

    SuperPathContained pathways About
    1Nuclear Receptor transcription pathway
    Nuclear Receptor transcription pathway0.67
    Nuclear Receptors0.67
    2Gene Expression
    Generic Transcription Pathway0.40
    Gene Expression0.40
    3Peptide ligand-binding receptors
    Neuroactive ligand-receptor interaction0.36
    4Development NOTCH1 mediated pathway for NF KB activity modulation
    Transcription Sin3 and NuRD in transcription regulation0.35
    5Transcription Role of VDR in regulation of genes involved in osteoporosis
    Transcription Role of VDR in regulation of genes involved in osteoporosis

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 GeneGo (Thomson Reuters) Pathways for THRA
        Transcription Sin3 and NuRD in transcription regulation
    Transcription Role of VDR in regulation of genes involved in osteoporosis

    2 BioSystems Pathways for THRA
        Nuclear Receptors
    Endochondral Ossification

    1 Reactome Pathway for THRA
        Nuclear Receptor transcription pathway


    2 Kegg Pathways  (Kegg details for THRA):
        Neuroactive ligand-receptor interaction
    Thyroid hormone signaling pathway


    THRA for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including THRA: 
              Nuclear Receptors & Coregulators in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for THRA

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for THRA (P108271, 3 ENSP000002646374) via UniProtKB, MINT, STRING, and/or I2D (see all 117)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MED1Q156481, 3, ENSP000003006514EBI-286285,EBI-394459 I2D: score=5 STRING: ENSP00000300651
    RXRBP287023, ENSP000003638124I2D: score=1 STRING: ENSP00000363812
    ENSG00000206289P287023I2D: score=1 
    ENSG00000227322P287023I2D: score=1 
    ENSG00000228333P287023I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 28):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001502cartilage condensation IEA--
    GO:0001503ossification IEA--
    GO:0002155regulation of thyroid hormone mediated signaling pathway IEA--
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0006357regulation of transcription from RNA polymerase II promoter IDA18052923

    THRA for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for THRA (THA)

    1 HMDB Compound for THRA    About this table
    CompoundSynonyms CAS #PubMed Ids
    Liothyronine3,3',5-Triiodo-L-thyronine (see all 20)6893-02-3--

    5 DrugBank Compounds for THRA    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Liotrix-- 8065-29-0targetagonist15283690 15240882 12955882 20615127 17139284 14596673 11752352 17016423 17315033 15235154
    Dextrothyroxine-- 51-49-0targetagonist15283690 15240882 12955882 14596673 17315033 15235154
    LiothyronineL-Liothyronine (see all 5)6893-02-3targetagonist15283690 15240882 12955882 14596673 11752352 15235154
    Levothyroxine(-)-Thyroxine (see all 13)51-48-9targetagonist20615127 17139284 11752352 17016423 17315033
    3,5-Dichloro-4-[(4-Hydroxy-3-Isopropylphenoxy)Phenylacetic Acid-- --target--10592235

    7 IUPHAR Ligands for THRA (Thyroid hormone receptor-alpha)    About this table
    LigandTypeActionAffinityPubmed IDs
    T3
    AgonistAgonist1012109914
    GC-1
    AgonistAgonist9.362158622
    NH-3
    AntagonistAntagonist7.6212109914
    KB-141
    AgonistAgonist7.612699376
    reverse triiodothyronine
    AgonistAgonist7.62158622
    T4
    AgonistAgonist7.62158622
    3,3',5-triiodothyroacetic acid
    AgonistAgonist7.62158622

    Selected Novoseek inferred chemical compound relationships for THRA gene (see all 11)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    triiodothyronine 77.5 8 16832786 (2), 2158465 (1), 14596673 (1), 14656206 (1) (see all 7)
    retinoic acid 64.5 20 1347914 (1), 8253072 (1), 8455948 (1), 9727048 (1) (see all 14)
    thyroxine 48.6 1 14596673 (1)
    estrogen 25.3 8 11378852 (2), 9824153 (1), 11687272 (1), 19034372 (1) (see all 6)
    vitamin d 15.7 5 1850510 (1), 19034372 (1), 9287395 (1)
    zinc 13.5 3 11501753 (1), 1954886 (1), 11290385 (1)
    oligonucleotide 0 2 8062948 (1), 15585599 (1)
    estradiol 0 1 12624541 (1)
    glucose 0 1 19636322 (1)
    progesterone 0 2 12624541 (2)

    1 PharmGKB related drug/compound annotation for THRA gene    About this table
    Drug/compound PharmGKB Annotation
    lithiumCA  



    THRA for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for THRA gene (4 alternative transcripts): 
    NM_001190918.1  NM_001190919.1  NM_003250.5  NM_199334.3  

    Unigene Cluster for THRA:

    Thyroid hormone receptor, alpha
    Hs.724  [show with all ESTs]
    Unigene Representative Sequence: AB209346
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000577288 ENST00000585047 ENST00000578218 ENST00000394121(uc021twy.1)
    ENST00000584985(uc002htx.3) ENST00000264637(uc002htw.3) ENST00000450525(uc002htv.3)
    ENST00000546243(uc010cwp.1) ENST00000577486 ENST00000577637
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat THRA using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate THRA (see all 54):
    hsa-miR-549 hsa-miR-106a hsa-miR-4272 hsa-miR-765 hsa-miR-128 hsa-miR-138-2* hsa-miR-519a hsa-miR-4267
    SwitchGear 3'UTR luciferase reporter plasmidTHRA 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for THRA
    Predesigned siRNA for gene silencing in human, mouse, rat THRA
    Clone
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    OriGene clones in human, mouse for THRA (see all 16)
    OriGene ORF clones in mouse, rat for THRA
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 4): THRA (NM_003250)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for THRA
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat THRA
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for THRA
    OriGene qSTAR qPCR primer pairs in human, mouse for THRA
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat THRA
      QuantiTect SYBR Green Assays in human, mouse, rat THRA
      QuantiFast Probe-based Assays in human, mouse, rat THRA

    Additional mRNA sequence: 

    AB209346.1 AB307686.1 AF522368.1 AK290071.1 AK290530.1 AK311344.1 BC000261.1 BC002728.2 
    BC035137.1 BC062421.1 CR541915.1 HQ692859.1 J03239.1 M24899.1 M24900.1 X55005.1 
    Y00479.1 

    21 DOTS entries:

    DT.118297  DT.118299  DT.100807968  DT.95378840  DT.87015530  DT.95251994  DT.91758665  DT.75124373 
    DT.91758657  DT.97847061  DT.100740261  DT.99953623  DT.100031087  DT.120980017  DT.87015531  DT.91740668 
    DT.100665357  DT.100783912  DT.120980106  DT.91937029  DT.92036477 

    Selected AceView cDNA sequences (see all 294):

    BQ529293 CA433614 AL134313 BC002728 AF522368 BQ672969 BQ897142 BM907134 
    BF197234 AL047482 BM706074 BU730463 CD108797 AI391498 BC062421 BC035137 
    CA454666 AL043801 CD671434 CR596083 BM700063 NM_003250 BQ669877 F09846 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    THRA expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCTGTATCCC
    THRA Expression
    About this image


    THRA expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Brain (Nervous System)    fully expand to see all 10 entries
             Thalamus
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Telencephalon
     
     Ovary (Reproductive System)
    THRA Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    THRA Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.724
        Pathway & Disease-focused RT2 Profiler PCR Array including THRA: 
              Nuclear Receptors & Coregulators in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for THRA gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Thra1 , 5 thyroid hormone receptor alpha1, 5 95.93(n)1
    99.27(a)1
      11 (62.58 cM)5
    218331  NM_178060.31  NP_835161.11 
     987406385 
    chicken
    (Gallus gallus)
    Aves THRA1 thyroid hormone receptor, alpha 84.97(n)
    90.44(a)
      396251  NM_205313.1  NP_990644.1 
    lizard
    (Anolis carolinensis)
    Reptilia THRA6
    thyroid hormone receptor, alpha
    91(a)
    1 ↔ 1
    6(69199274-69334548)
    African clawed frog
    (Xenopus laevis)
    Amphibia LOC3979422 Xenopus laevis thyroid hormone receptor alpha A mRNA, more 84.62(n)    M35343.1 
    zebrafish
    (Danio rerio)
    Actinopterygii thra2 thyroid hormone receptor alpha 80.52(n)   30670  NM_131396.1 


    ENSEMBL Gene Tree for THRA (if available)
    TreeFam Gene Tree for THRA (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for THRA gene
    VDR2  PPARD2  RARG2  NR1I22  PPARA2  THRB2  RARA2  NR1H42  
    NR1D22  RARB2  RORA2  RORB2  RORC2  NR1D12  NR1I32  PPARG2  
    NR1H22  NR1H32  
    Selected SIMAP similar genes for THRA using alignment to 6 protein entries:     THA_HUMAN (see all proteins) (see all similar genes):
    NR1A1    THRB    NR1A2    HNF4G    ESR1    NR3C2
    HNF4alpha    VDR    NR1I3    NR1H3    BCOR-RARA    NR1B3
    RARA    RARG    PML-RAR    ESRRA    NR1B2    RARB

    THRA for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for THRA (see all 707)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs360211401,2
    C--38217019(+) TGTCTT/-TTGAG 1 -- us2k11Minor allele frequency- -:0.50NA 2
    rs585299951,2
    C--38238642(+) TTTTT-/TCTTTT 4 -- int10--------
    rs620652181,2
    F--38239324(+) TACAGC/TGCCCA 4 -- int11Minor allele frequency- T:0.50NA 2
    rs14672581,2
    C--39003809(+) AGATGA/GGGCAA 1 -- us2k15Minor allele frequency- G:0.14NA WA EA 362
    rs75029661,2
    C,F,A,H--39003844(+) AGACAT/CGGGCT 1 -- us2k124Minor allele frequency- C:0.39NS EA NA WA CSA 2343
    rs116551151,2
    C,H--39004091(+) ccttcC/Tctacc 1 -- us2k1 trp30--------
    rs1930486971,2
    --39004120(+) AAAGCA/GAAAAA 1 -- us2k10--------
    rs1857564051,2
    --39004197(+) AAATCC/TCTTGA 1 -- us2k10--------
    rs1890209631,2
    --39004213(+) GGAGAC/TGGAGG 1 -- us2k10--------
    rs346700051,2
    C,F--39004255(+) CCAGCT/CTGGGC 1 -- us2k16Minor allele frequency- C:0.36NA WA CSA 11

    HapMap Linkage Disequilibrium report for THRA (38214543 - 38250120 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for THRA:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv908221CNV Loss21882294
    nsv833444CNV Loss17160897

    Human Gene Mutation Database (HGMD): THRA
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing THRA
    DNA2.0 Custom Variant and Variant Library Synthesis for THRA

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 190120   
    OMIM disorders: 614450  
    UniProtKB/Swiss-Prot: THA_HUMAN, P10827
  • Hypothyroidism, congenital, non-goitrous, 6 (CHNG6) [MIM:614450]: A disease characterized by growth
    retardation, developmental retardation, skeletal dysplasia, borderline low thyroxine levels and high
    triiodothyronine levels. There is differential sensitivity to thyroid hormone action, with retention of hormone
    responsiveness in the hypothalamic pituitary axis and liver but skeletal, gastrointestinal, and myocardial
    resistance. Note=The disease is caused by mutations affecting the gene represented in this entry

  • Selected diseases for THRA (see all 39):    
    About MalaCards
    hypothyroidism, congenital, nongoitrous, 6    hyperthyroxinemia    thyroiditis    glanzmann's thrombasthenia
    follicular thyroid carcinoma    congenital diaphragmatic hernia    thrombasthenia    thyroid cancer
    congenital hypothyroidism    renal clear cell carcinoma    skeletal dysplasias    dwarfism
    morbid obesity    hematopoietic stem cell transplantation    hypothyroidism    acute promyelocytic leukemia
    septic shock    liposarcoma    pituitary tumors    obesity

    1 disease from the University of Copenhagen DISEASES database for THRA:
    Hypothyroidism

    THRA for disorders           About GeneDecksing

    Selected Novoseek inferred disease relationships for THRA gene (see all 12)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    osteoclastoma 58.9 2 10807056 (2)
    thyroid cancer 31.5 4 12231529 (4)
    erythroleukemia 30.8 1 11420726 (1)
    hypertrophy 15.3 2 15831522 (1)
    breast carcinoma 0 1 7737350 (1)
    breast cancer 0 3 16832786 (2), 9695977 (1)
    metastasis 0 2 11741739 (1), 20062085 (1)
    ovarian cancer 0 1 8460637 (1)
    nsclc 0 1 12911822 (1)
    tumors 0 12 10487522 (3), 12231529 (2), 10022432 (1), 10822129 (1) (see all 8)

    Genatlas disease: THRA
    hyperthyroxinemia,euthyroidal

    Genetic Association Database (GAD): THRA
    Human Genome Epidemiology (HuGE) Navigator: THRA (11 documents)
    Tumor Gene Database (TGDB): THRA

    Export disorders for THRA gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for THRA gene, integrated from 10 sources (see all 294):
    (articles sorted by number of sources associating them with THRA)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genomic organization of the human thyroid hormone receptor alpha (c- erbA-1) gene. (PubMed id 1850510)1, 2, 9 Laudet V....Saule S. (Nucleic Acids Res. 1991)
    2. Identification and consequences of polymorphisms in the thyroid hormone receptor alpha and beta genes. (PubMed id 18844476)1, 4, 9 SA...Visser T.J. (Thyroid 2008)
    3. Meta-analyses of genes modulating intracellular T3 bio-availability reveal a possible role for the DIO3 gene in osteoarthritis susceptibility. (PubMed id 20724312)1, 4 Meulenbelt I....Slagboom P.E. (Ann. Rheum. Dis. 2011)
    4. Study of thyroid hormone receptor alpha gene polymorphisms on Alzheimer's disease. (PubMed id 19427062)1, 4 Goumidi L....Meirhaeghe A. (Neurobiol. Aging 2011)
    5. Association of CR1, CLU and PICALM with Alzheimer's disease in a cohort of clinically characterized and neuropathologically verified individuals. (PubMed id 20534741)1, 4 Corneveaux J.J....Huentelman M.J. (Hum. Mol. Genet. 2010)
    6. Association of polymorphisms in estrogen and thyroid hormone receptors with thyroid cancer risk. (PubMed id 19519176)1, 4 RebaA^ M....RebaA^ A. (J. Recept. Signal Transduct. Res. 2009)
    7. The variant rs1867277 in FOXE1 gene confers thyroid cancer susceptibility through the recruitment of USF1/USF2 transcription factors. (PubMed id 19730683)1, 4 Landa I....Robledo M. (PLoS Genet. 2009)
    8. High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. (PubMed id 19453261)1, 4 Yerges L.M....Zmuda J.M. (J. Bone Miner. Res. 2009)
    9. Gaining ligand selectivity in thyroid hormone receptors via entropy. (PubMed id 19926848)1, 2 Martinez L.... Polikarpov I. (Proc. Natl. Acad. Sci. U.S.A. 2009)
    10. Proteomic analysis of ubiquitinated proteins in normal hepatocyte cell line Chang liver cells. (PubMed id 18655026)1, 2 Tan F.... Peng X. (Proteomics 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 7067 HGNC: 11796 AceView: THRA Ensembl:ENSG00000126351 euGenes: HUgn7067
    ECgene: THRA Kegg: 7067 H-InvDB: THRA

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for THRA Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for THRA Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for THRA gene:
    Search GeneIP for patents involving THRA

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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