Aliases for THRA Gene
External Ids for THRA Gene
Previous HGNC Symbols for THRA Gene
Previous GeneCards Identifiers for THRA Gene
The protein encoded by this gene is a nuclear hormone receptor for triiodothyronine. It is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions of thyroid hormone. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
GeneCards Summary for THRA Gene
THRA (Thyroid Hormone Receptor, Alpha) is a Protein Coding gene. Diseases associated with THRA include hypothyroidism, congenital, nongoitrous, 6 and peripheral resistance to thyroid hormones. Among its related pathways are Gene Expression and Endochondral Ossification. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and transcription factor binding. An important paralog of this gene is NR4A2.
UniProtKB/Swiss-Prot for THRA Gene
Isoform Alpha-1: Nuclear hormone receptor that can act as a repressor or activator of transcription. High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine.
Isoform Alpha-2: Does not bind thyroid hormone and functions as a weak dominant negative inhibitor of thyroid hormone action.