Aliases for THPO Gene
External Ids for THPO Gene
Previous HGNC Symbols for THPO Gene
Previous GeneCards Identifiers for THPO Gene
Megakaryocytopoiesis is the cellular development process that leads to platelet production. The main functional protein encoded by this gene is a humoral growth factor that is necessary for megakaryocyte proliferation and maturation, as well as for thrombopoiesis. This protein is the ligand for MLP/C_MPL, the product of myeloproliferative leukemia virus oncogene. Mutations in this gene are the cause of thrombocythemia 1. Alternative promoter usage and differential splicing result in multiple transcript variants differing in the 5' UTR and/or coding region. Multiple AUG codons upstream of the main open reading frame (ORF) have been identified, and these upstream AUGs inhibit translation of the main ORF at different extent. [provided by RefSeq, Feb 2014]
GeneCards Summary for THPO Gene
THPO (Thrombopoietin) is a Protein Coding gene. Diseases associated with THPO include Thrombocythemia 1 and Hereditary Thrombocytosis With Transverse Limb Defect. Among its related pathways are Integrin alphaIIb beta3 signaling and p70S6K Signaling. GO annotations related to this gene include cytokine activity and hormone activity.
UniProtKB/Swiss-Prot for THPO Gene
Lineage-specific cytokine affecting the proliferation and maturation of megakaryocytes from their committed progenitor cells. It acts at a late stage of megakaryocyte development. It may be the major physiological regulator of circulating platelets.