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Aliases for THOP1 Gene

Aliases for THOP1 Gene

  • Thimet Oligopeptidase 1 2 3 5
  • Endopeptidase 24.15 3 4
  • EC 3.4.24.15 4 61
  • MP78 3 4
  • Thimet Oligopeptidase 3
  • MEPD_HUMAN 3
  • EC 3.4.24 61
  • EP24.15 3
  • TOP 3

External Ids for THOP1 Gene

Previous GeneCards Identifiers for THOP1 Gene

  • GC19P002848
  • GC19P002725
  • GC19P002736
  • GC19P002554

Summaries for THOP1 Gene

Entrez Gene Summary for THOP1 Gene

  • The protein encoded by this gene is a kininase that uses zinc as a cofactor. The encoded oligopeptidase cleaves cytosolic peptides, making them unavailable for display on antigen-presenting cells. This protein also cleaves neuropeptides under 20 aa in length and can degrade beta-amyloid precursor protein to amyloidogenic peptides. [provided by RefSeq, Nov 2015]

GeneCards Summary for THOP1 Gene

THOP1 (Thimet Oligopeptidase 1) is a Protein Coding gene. Among its related pathways are Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics and African trypanosomiasis. GO annotations related to this gene include peptidase activity and peptide binding. An important paralog of this gene is NLN.

UniProtKB/Swiss-Prot for THOP1 Gene

  • Involved in the metabolism of neuropeptides under 20 amino acid residues long. Involved in cytoplasmic peptide degradation. Able to degrade the beta-amyloid precursor protein and generate amyloidogenic fragments.

Gene Wiki entry for THOP1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for THOP1 Gene

Genomics for THOP1 Gene

Regulatory Elements for THOP1 Gene

Enhancers for THOP1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F002810 0.8 ENCODE 33.1 +26.2 26171 1.9 MLX ARID4B DMAP1 RARA YY1 SLC30A9 MIXL1 THAP11 SP5 MXD4 THOP1 GC19P002822
GH19F002798 0.2 ENCODE 33 +13.6 13558 0.8 FOSL1 NCOR1 KLF17 THOP1 ZNF57 LOC101928631 GC19P002822
GH19F002787 0.6 Ensembl 32.7 +1.8 1841 0.2 ZNF341 THOP1 GC19P002822
GH19F002781 0.2 ENCODE 30.2 -1.1 -1131 4.9 HDGF PKNOX1 ARNT MLX CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 ZNF554 THOP1 SF3A2 CACTIN-AS1 SGTA
GH19F002819 0.7 ENCODE 23 +34.5 34496 1.5 CREB3L1 ARID4B SIN3A ZNF2 YY1 ZNF766 ZNF207 ZNF143 KLF13 SP3 ZNF554 THOP1 ZNF556 ZNF57 LOC101928631 SLC39A3 ZNF77 GC19P002827
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around THOP1 on UCSC Golden Path with GeneCards custom track

Promoters for THOP1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000042464 440 1800 HDGF PKNOX1 ATF1 ARNT CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2

Genomic Location for THOP1 Gene

Chromosome:
19
Start:
2,785,460 bp from pter
End:
2,815,807 bp from pter
Size:
30,348 bases
Orientation:
Plus strand

Genomic View for THOP1 Gene

Genes around THOP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
THOP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for THOP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for THOP1 Gene

Proteins for THOP1 Gene

  • Protein details for THOP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P52888-THOP1_HUMAN
    Recommended name:
    Thimet oligopeptidase
    Protein Accession:
    P52888
    Secondary Accessions:
    • B3KSE2
    • Q9UCB3

    Protein attributes for THOP1 Gene

    Size:
    689 amino acids
    Molecular mass:
    78840 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    • Monomer.

    Three dimensional structures from OCA and Proteopedia for THOP1 Gene

    Alternative splice isoforms for THOP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for THOP1 Gene

Post-translational modifications for THOP1 Gene

  • Ubiquitination at Lys 220, Lys 239, Lys 301, Lys 538, and Lys 559
  • Modification sites at PhosphoSitePlus

Antibody Products

  • R&D Systems Antibodies for THOP1 (Thimet Oligopeptidase/THOP1)
  • Cloud-Clone Corp. Antibodies for THOP1

Domains & Families for THOP1 Gene

Protein Domains for THOP1 Gene

Graphical View of Domain Structure for InterPro Entry

P52888

UniProtKB/Swiss-Prot:

THOP1_HUMAN :
  • Belongs to the peptidase M3 family.
Family:
  • Belongs to the peptidase M3 family.
genes like me logo Genes that share domains with THOP1: view

No data available for Gene Families for THOP1 Gene

Function for THOP1 Gene

Molecular function for THOP1 Gene

GENATLAS Biochemistry:
Thimet oligopeptidase 1,expressed in brain,homolog of the rat metalloendopeptidase 24.15,involved in antigen presentation via MHC class 1
UniProtKB/Swiss-Prot CatalyticActivity:
Preferential cleavage of bonds with hydrophobic residues at P1, P2 and P3 and a small residue at P1 in substrates of 5 to 15 residues.
UniProtKB/Swiss-Prot Function:
Involved in the metabolism of neuropeptides under 20 amino acid residues long. Involved in cytoplasmic peptide degradation. Able to degrade the beta-amyloid precursor protein and generate amyloidogenic fragments.

Enzyme Numbers (IUBMB) for THOP1 Gene

Gene Ontology (GO) - Molecular Function for THOP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004222 metalloendopeptidase activity IEA --
GO:0005515 protein binding IPI 19614740
GO:0008233 peptidase activity IEA --
GO:0008237 metallopeptidase activity IEA --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with THOP1: view
genes like me logo Genes that share phenotypes with THOP1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for THOP1

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for THOP1 Gene

Localization for THOP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for THOP1 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for THOP1 Gene COMPARTMENTS Subcellular localization image for THOP1 gene
Compartment Confidence
cytosol 4
mitochondrion 4
extracellular 2
nucleus 2
endoplasmic reticulum 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for THOP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005758 mitochondrial intermembrane space IBA --
genes like me logo Genes that share ontologies with THOP1: view

Pathways & Interactions for THOP1 Gene

genes like me logo Genes that share pathways with THOP1: view

Pathways by source for THOP1 Gene

2 KEGG pathways for THOP1 Gene

Gene Ontology (GO) - Biological Process for THOP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0006518 peptide metabolic process IBA --
genes like me logo Genes that share ontologies with THOP1: view

No data available for SIGNOR curated interactions for THOP1 Gene

Drugs & Compounds for THOP1 Gene

(1) Drugs for THOP1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(2) Additional Compounds for THOP1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with THOP1: view

Transcripts for THOP1 Gene

Unigene Clusters for THOP1 Gene

Thimet oligopeptidase 1:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for THOP1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c · 10d ^ 11a · 11b ^ 12a · 12b · 12c · 12d ^ 13 ^
SP1: - -
SP2:
SP3: - - - -
SP4: -
SP5:
SP6: -
SP7: - - -
SP8: - -
SP9: - -

ExUns: 14 ^ 15 ^ 16 ^ 17
SP1: - -
SP2:
SP3:
SP4:
SP5: -
SP6:
SP7:
SP8:
SP9:

Relevant External Links for THOP1 Gene

GeneLoc Exon Structure for
THOP1
ECgene alternative splicing isoforms for
THOP1

Expression for THOP1 Gene

mRNA expression in normal human tissues for THOP1 Gene

Protein differential expression in normal tissues from HIPED for THOP1 Gene

This gene is overexpressed in Lymph node (13.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for THOP1 Gene



Protein tissue co-expression partners for THOP1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of THOP1 Gene:

THOP1

SOURCE GeneReport for Unigene cluster for THOP1 Gene:

Hs.78769
genes like me logo Genes that share expression patterns with THOP1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for THOP1 Gene

Orthologs for THOP1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for THOP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia THOP1 34 35
  • 96.75 (n)
dog
(Canis familiaris)
Mammalia THOP1 34 35
  • 87.67 (n)
cow
(Bos Taurus)
Mammalia THOP1 34 35
  • 86.89 (n)
rat
(Rattus norvegicus)
Mammalia Thop1 34
  • 84.55 (n)
mouse
(Mus musculus)
Mammalia Thop1 34 16 35
  • 84.24 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia THOP1 35
  • 75 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia THOP1 35
  • 70 (a)
OneToOne
chicken
(Gallus gallus)
Aves THOP1 35
  • 81 (a)
OneToOne
LOC426398 34
  • 78.45 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia thop1 34
  • 67.02 (n)
Str.15329 34
African clawed frog
(Xenopus laevis)
Amphibia LOC397806 34
zebrafish
(Danio rerio)
Actinopterygii thop1 35
  • 72 (a)
OneToOne
zgc:92139 34
  • 71.96 (n)
wufb74b01 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10066 34
fruit fly
(Drosophila melanogaster)
Insecta CG11771 36 35
  • 24 (a)
worm
(Caenorhabditis elegans)
Secernentea ZK550.3 35
  • 17 (a)
OneToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGR406C 34
  • 48.36 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PRD1 35 37
  • 35 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G67690 34
  • 45.28 (n)
rice
(Oryza sativa)
Liliopsida Os01g0902200 34
  • 45 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4245 35
  • 59 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.9293 34
Species where no ortholog for THOP1 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for THOP1 Gene

ENSEMBL:
Gene Tree for THOP1 (if available)
TreeFam:
Gene Tree for THOP1 (if available)

Paralogs for THOP1 Gene

Paralogs for THOP1 Gene

genes like me logo Genes that share paralogs with THOP1: view

Variants for THOP1 Gene

Sequence variations from dbSNP and Humsavar for THOP1 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs10408115 -- 2,805,875(+) ACTGC(A/G)GGGGG intron-variant
rs10408116 -- 2,805,876(+) CTGCG(A/G)GGGGA intron-variant
rs10409707 -- 2,805,854(+) GGGGA(C/T)GGGCG intron-variant
rs10409914 -- 2,805,910(+) GGGGA(C/T)GGGCG intron-variant
rs10411205 -- 2,788,021(+) acaat(G/T)ggggg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for THOP1 Gene

Variant ID Type Subtype PubMed ID
esv1006393 CNV deletion 20482838
esv1039020 CNV insertion 17803354
esv1432748 CNV deletion 17803354
esv2717912 CNV deletion 23290073
esv2717913 CNV deletion 23290073
nsv509714 CNV insertion 20534489
nsv509715 CNV insertion 20534489
nsv828397 CNV gain 20364138

Variation tolerance for THOP1 Gene

Residual Variation Intolerance Score: 14.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.10; 51.03% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for THOP1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
THOP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for THOP1 Gene

Disorders for THOP1 Gene

Relevant External Links for THOP1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
THOP1

No disorders were found for THOP1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for THOP1 Gene

Publications for THOP1 Gene

  1. Increased expression of the oligopeptidase THOP1 is a neuroprotective response to Abeta toxicity. (PMID: 18571100) Pollio G. … Terstappen G.C. (Neurobiol. Dis. 2008) 3 22 64
  2. Swapping the substrate specificities of the neuropeptidases neurolysin and thimet oligopeptidase. (PMID: 17251185) Lim E.J. … Rodgers D.W. (J. Biol. Chem. 2007) 3 4 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. Crystal structure of human thimet oligopeptidase provides insight into substrate recognition, regulation, and localization. (PMID: 14998993) Ray K. … Rodgers D.W. (J. Biol. Chem. 2004) 3 22 64
  5. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J. … Lucas S.M. (Nature 2004) 3 4 64

Products for THOP1 Gene

Sources for THOP1 Gene

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