THOP1 Gene
protein-coding GIFtS: 65
GCID: GC19P002785
|
|
thimet oligopeptidase 1
| |
Aliases
for THOP1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Thimet Oligopeptidase 11 2 | | MEPD_HUMAN2 | | Endopeptidase 24.152 3 | | TOP2 | | MP782 3 | | Thimet Oligopeptidase2 | | EC 3.4.24.153 8 | | EC 3.4.248 | | EP24.152 | | |
Export aliases for THOP1 gene to outside databasesPrevious GC identifers: GC19P002848 GC19P002725 GC19P002736 GC19P002554 |
Summaries
for THOP1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: THOP1_HUMAN, P52888Function: Involved in the metabolism of neuropeptides under 20 amino acid residues long. Involved in cytoplasmicpeptide degradation. Able to degrade the beta-amyloid precursor protein and generate amyloidogenic fragments
Gene Wiki entry for THOP1
|
Genomic Views
for THOP1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011255.14
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the THOP1 gene promoter:
CREB SRY deltaCREB
Other transcription factors
Search SABiosciences Chromatin IP Primers for THOP1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat THOP1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19p13.3 Ensembl cytogenetic band: 19p13.3 HGNC cytogenetic band: 19p13.3THOP1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19P002785: view genomic region
(about GC identifiers)
Start:
|
2,785,458 bp from pter |
End:
|
2,813,599 bp from pter |
Size:
|
28,142 bases |
Orientation:
|
plus strand |
|
Proteins
for THOP1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: THOP1_HUMAN, P52888 (See
protein sequence)Recommended Name: Thimet oligopeptidase Size: 689 amino acids; 78840 Da
Cofactor: Binds 1 zinc ion per subunit
Subunit: Monomer (By similarity)
Subcellular location: Cytoplasm
2 PDB 3D structures from  and Proteopedia  for THOP1:1S4B (3D)
2O36 (3D)
Secondary accessions: Q9UCB3Explore the universe of human proteins at neXtProt for THOP1: NX_P52888
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P52888
4/24 DME Specific Peptides for THOP1 (P52888) (see all 24)
THOP1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_003240.1
ENSEMBL proteins: ENSP00000304467 ENSP00000465545 ENSP00000467226 ENSP00000466653 ENSP00000465855 ENSP00000465895 ENSP00000378638 ENSP00000464786
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
THOP1 for ontologies About GeneDecksing
THOP1 Antibody Products:
Assay Products for THOP1: |
Protein
Domains /
Families
for THOP1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
THOP1 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P52888ProtoNet protein and cluster: P52888 1 Blocks protein family: IPB001567 Peptidase M3
UniProtKB/Swiss-Prot: THOP1_HUMAN, P52888Similarity: Belongs to the peptidase M3 family |
Function
for THOP1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: THOP1_HUMAN, P52888Function: Involved in the metabolism of neuropeptides under 20 amino acid residues long. Involved in cytoplasmicpeptide degradation. Able to degrade the beta-amyloid precursor protein and generate amyloidogenic fragmentsCatalytic activity: Preferential cleavage of bonds with hydrophobic residues at P1, P2 and P3' and a small residue atP1' in substrates of 5 to 15 residues Genatlas biochemistry entry for THOP1:Thimet oligopeptidase 1,expressed in brain,homolog of the rat metalloendopeptidase 24.15,involved in antigenpresentation via MHC class 1
Enzyme Numbers (IUBMB): EC 3.4.24.151 2 EC 3.4.242
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for THOP1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for THOP1 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: THOP1 (NM_003249) | |  | Sino Biological Human cDNA Clone for THOP1 | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for THOP1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat THOP1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for THOP1 |
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table
THOP1 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for THOP1:
|
Pathways & Interactions
for THOP1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Selected targets of GCR-alpha | | | 2 | African trypanosomiasis | | | 3 | Renin-angiotensin system | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 EMD Millipore Pathway for THOP1
2 
Kegg Pathways (Kegg details for THOP1):
THOP1 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for THOP1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 10)
5/18 Interacting proteins for THOP1 (P528882, 3 ENSP000003044674) via UniProtKB, MINT, STRING, and/or I2D (see all 18)About this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006508 | proteolysis |
IEA | -- | | GO:0006518 | peptide metabolic process |
IEA | -- | | GO:0007243 | intracellular protein kinase cascade |
IEA | -- |
THOP1 for ontologies About GeneDecksing
|
Drugs & Compounds
for THOP1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
THOP1 for compounds About GeneDecksing
 Browse Tocris compounds for THOP1
6 HMDB Compounds for THOP1 About this table
3 Novoseek chemical compound relationships for THOP1 gene About this table
Search CenterWatch for drugs/clinical trials and news about THOP1
|
Transcripts
for THOP1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for THOP1 gene: NM_003249.3 Unigene Cluster for THOP1: Thimet oligopeptidase 1 Hs.78769 [show with all ESTs]Unigene Representative Sequence: BC06728114 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000307741(uc002lwj.3 uc010xgz.2) ENST00000585673 ENST00000585338
ENST00000586780 ENST00000586677 ENST00000589087 ENST00000591149 ENST00000590533
ENST00000591363 ENST00000590970 ENST00000587401 ENST00000395212(uc002lwk.3)
ENST00000592639 ENST00000587468
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for THOP1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for THOP1 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: THOP1 (NM_003249) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for THOP1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat THOP1 |
Additional cDNA sequence: AK093392.1 AK300552.1 BC000135.2 BC000583.2 BC002391.2 BC013878.2 BC067281.1 BC150150.1 U29366.1 Z50115.1 12 DOTS entries: DT.113148 DT.100805785 DT.100029471 DT.92442224 DT.100797035 DT.100800951 DT.92442242 DT.92442225 DT.92442246 DT.100797043 DT.92442245 DT.99968783 24/285 AceView cDNA sequences (see all 285): CF145811 BU859040 BG388598 BM764790 BM980683 BM757116 AK093392 BM764527 BI161180 BC002391 BQ711921 CF135486 BX385668 AI695886 BU195253 AW192515 BG260342 BU845173 AW501845 BG180024 AI739282 BC000135 BU152989 AI765138
GeneLoc Exon Structure
5/9 Alternative Splicing Database (ASD) splice patterns (SP) for THOP1 (see all 9) About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | · | 5c | · | 5d | ^ | 6a | · | 6b | ^ | 7a | · | 7b | ^ | 8 | ^ | 9a | · | 9b | ^ | 10a | · | 10b | · | 10c | · | 10d | ^ | 11a | · | 11b | ^ | 12a | · | 12b | · | 12c | · | 12d | ^ | 13 | ^ |
|---|
|
| SP1: | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | - | | | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 14 | ^ | 15 | ^ | 16 | ^ | 17 |
|---|
|
| SP1: | | | - | | - | | | | |
| SP2: | | | | | | | | | |
| SP3: | | | | | | | | | |
| SP4: | | | | | | | | | |
| SP5: | | | - | | | | | |
ECgene alternative splicing isoforms for THOP1
|
Expression
for THOP1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| THOP1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTGAGGCGCT
About this image
See THOP1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for THOP1
SOURCE GeneReport for Unigene cluster: Hs.78769
SABiosciences Custom PCR Arrays for THOP1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for THOP1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat THOP1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat THOP1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat THOP1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for THOP1 |
Orthologs
for THOP1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the last universal common ancestor (LUCA).
Orthologs for THOP1 gene from 9/32 species (see all 32) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
LOC4263981 |
thimet oligopeptidase-like |
78.45(n)
83.28(a) |
|
426398 XM_424048.3 XP_424048.3 |
African clawed frog
(Xenopus laevis) |
Amphibia |
LOC3978062 |
thimet oligopeptidase |
74.57(n) |
|
AB030904.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
wufb74b012 |
wufb74b01 |
77.39(n) |
|
322818 CA473927.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
CG117713 |
oligopeptidase A |
24(a) |
|
96B10 -- |
worm
(Caenorhabditis elegans) |
Secernentea |
ZK550.36 |
-- |
16(a) |
possible ortholog |
IV(17250094-17254927) |
A. gossypii yeast
(Ashbya gossypii) |
Saccharomycetes |
AGOS_AGR406C1 |
AGR406Cp |
48.56(n)
38.85(a) |
|
4623376 NM_212134.1 NP_987072.1 |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
AT1G676901 |
zincin-like metalloproteases-like protein |
45.17(n)
35.68(a) |
|
843094 NM_105437.4 NP_564902.4 |
rice
(Oryza sativa) |
Liliopsida |
Os01g09022001 |
hypothetical protein |
44.65(n)
35.05(a) |
|
4325012 NM_001051651.1 NP_001045116.1 |
E. coli
(Escherichia coli) |
Gamma proteobacteria |
prlC6dcp6 |
dipeptidyl carboxypeptidase II |
28(a)24(a) |
possible orthologpossible ortholog |
Chromosome(3641163-3643205) Chromosome(1623359-1625404) |
ENSEMBL Gene Tree for THOP1 (if available)
TreeFam Gene Tree for THOP1 (if available) |
Paralogs
for THOP1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for THOP1 gene
- NLN2
2 SIMAP similar genes for THOP1 using alignment to 10 protein entries: THOP1_HUMAN (see all proteins):DKFZp564F123 NLN
THOP1 for paralogs About GeneDecksing
|
Genomic Variants
for THOP1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for THOP1 (2785458 - 2813599 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for THOP1: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing THOP1 |
|
Disorders
/ Diseases
for THOP1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
THOP1 for disorders About GeneDecksing
OMIM gene information: 601117
OMIM disorders: --
3  diseases for THOP1: About MalaCardsureterolithiasis trypanosomiasis alzheimer's disease
3 diseases from the University of Copenhagen DISEASES database for THOP1:Posterior cerebral artery infarction Brain stem infarction Anosognosia Export disorders for THOP1 gene to outside databases
|
Publications
for THOP1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for THOP1 gene, integrated from 9 sources (see all 46):
(articles sorted by number of sources associating them with THOP1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Swapping the substrate specificities of the neuropeptidases neurolysin and thimet oligopeptidase. (PubMed id 17251185)1, 2 Lim E.J....Rodgers D.W. (2007)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)1, 2 Grimwood J.... Lucas S.M. (2004)
- Human endopeptidase 24.15 (THOP1) is localized on chromosome 19p13.3 and is excluded from the linkage region for late-onset Alzheimer disease. (PubMed id 9790774)1, 3 Torres M.P....Lennon G. (1998)
- Cloning and functional expression of a metalloendopeptidase from human brain with the ability to cleave a beta-APP substrate peptide. (PubMed id 7639763)1, 2 Thompson A.... Malherbe P. (1995)
- Identification of a metalloprotease from Alzheimer's disease brain able to degrade the beta-amyloid precursor protein and generate amyloidogenic fragments. (PubMed id 8286339)1, 2 Papastoitsis G.... Abraham C.R. (1994)
- Increased expression of the oligopeptidase THOP1 is a neuroprotective response to Abeta toxicity. (PubMed id 18571100)1, 9 Pollio G....Terstappen G.C. (2008)
- Human thimet oligopeptidase. (PubMed id 8373360)1, 9 Dando P.M....Barrett A.J. (1993)
- Crystal structure of human thimet oligopeptidase provides insight into substrate recognition, regulation, and localization. (PubMed id 14998993)1, 9 Ray K....Rodgers D.W. (2004)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
|
External Searches for THOP1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing THOP1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing THOP1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing THOP1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for THOP1 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for THOP1 gene:
Search GeneIP for patents involving THOP1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for THOP1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | OriGene Antibodies for THOP1 | | Browse OriGene shRNA RFPs | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for THOP1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for THOP1 | | | OriGene Protein Over-expression Lysate for THOP1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for THOP1 | | OriGene 3'-UTR Clone for THOP1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for THOP1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for THOP1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for THOP1 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for THOP1 | | OriGene Custom Protein Services for THOP1 | | | OriGene Custom Immunoassay Development | | |
| |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat THOP1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing THOP1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat THOP1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat THOP1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat THOP1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat THOP1 |
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| | | | Search Tocris compounds for THOP1 |
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 | | | THOP1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for THOP1 |
|  |  |  | | | | ThermoFisher Antibodies for THOP1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat THOP1 |
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