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Aliases for THOP1 Gene

Aliases for THOP1 Gene

  • Thimet Oligopeptidase 1 2 3 5
  • Endopeptidase 24.15 3 4
  • EC 3.4.24.15 4 63
  • MP78 3 4
  • MEPD_HUMAN 3
  • EC 3.4.24 63
  • EP24.15 3
  • TOP 3

External Ids for THOP1 Gene

Previous GeneCards Identifiers for THOP1 Gene

  • GC19P002848
  • GC19P002725
  • GC19P002736
  • GC19P002554

Summaries for THOP1 Gene

Entrez Gene Summary for THOP1 Gene

  • The protein encoded by this gene is a kininase that uses zinc as a cofactor. The encoded oligopeptidase cleaves cytosolic peptides, making them unavailable for display on antigen-presenting cells. This protein also cleaves neuropeptides under 20 aa in length and can degrade beta-amyloid precursor protein to amyloidogenic peptides. [provided by RefSeq, Nov 2015]

GeneCards Summary for THOP1 Gene

THOP1 (Thimet Oligopeptidase 1) is a Protein Coding gene. Among its related pathways are Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics and African trypanosomiasis. GO annotations related to this gene include peptidase activity and peptide binding. An important paralog of this gene is NLN.

UniProtKB/Swiss-Prot for THOP1 Gene

  • Involved in the metabolism of neuropeptides under 20 amino acid residues long. Involved in cytoplasmic peptide degradation. Able to degrade the beta-amyloid precursor protein and generate amyloidogenic fragments.

Gene Wiki entry for THOP1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for THOP1 Gene

Genomics for THOP1 Gene

Regulatory Elements for THOP1 Gene

Promoters for THOP1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around THOP1 on UCSC Golden Path with GeneCards custom track

Genomic Location for THOP1 Gene

Chromosome:
19
Start:
2,785,460 bp from pter
End:
2,815,807 bp from pter
Size:
30,348 bases
Orientation:
Plus strand

Genomic View for THOP1 Gene

Genes around THOP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
THOP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for THOP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for THOP1 Gene

Proteins for THOP1 Gene

  • Protein details for THOP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P52888-THOP1_HUMAN
    Recommended name:
    Thimet oligopeptidase
    Protein Accession:
    P52888
    Secondary Accessions:
    • B3KSE2
    • Q9UCB3

    Protein attributes for THOP1 Gene

    Size:
    689 amino acids
    Molecular mass:
    78840 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    • Monomer.

    Three dimensional structures from OCA and Proteopedia for THOP1 Gene

    Alternative splice isoforms for THOP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for THOP1 Gene

Proteomics data for THOP1 Gene at MOPED

Post-translational modifications for THOP1 Gene

  • Ubiquitination at Lys 220, Lys 239, Lys 301, Lys 538, and Lys 559
  • Modification sites at PhosphoSitePlus

Antibody Products

  • R&D Systems Antibodies for THOP1 (Thimet Oligopeptidase/THOP1)

Domains & Families for THOP1 Gene

Protein Domains for THOP1 Gene

Graphical View of Domain Structure for InterPro Entry

P52888

UniProtKB/Swiss-Prot:

THOP1_HUMAN :
  • Belongs to the peptidase M3 family.
Family:
  • Belongs to the peptidase M3 family.
genes like me logo Genes that share domains with THOP1: view

No data available for Gene Families for THOP1 Gene

Function for THOP1 Gene

Molecular function for THOP1 Gene

GENATLAS Biochemistry:
Thimet oligopeptidase 1,expressed in brain,homolog of the rat metalloendopeptidase 24.15,involved in antigen presentation via MHC class 1
UniProtKB/Swiss-Prot CatalyticActivity:
Preferential cleavage of bonds with hydrophobic residues at P1, P2 and P3 and a small residue at P1 in substrates of 5 to 15 residues.
UniProtKB/Swiss-Prot Function:
Involved in the metabolism of neuropeptides under 20 amino acid residues long. Involved in cytoplasmic peptide degradation. Able to degrade the beta-amyloid precursor protein and generate amyloidogenic fragments.

Enzyme Numbers (IUBMB) for THOP1 Gene

Gene Ontology (GO) - Molecular Function for THOP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004222 metalloendopeptidase activity IEA --
GO:0005515 protein binding IPI 19614740
GO:0008237 metallopeptidase activity IEA --
genes like me logo Genes that share ontologies with THOP1: view
genes like me logo Genes that share phenotypes with THOP1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for THOP1

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for THOP1 Gene

Localization for THOP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for THOP1 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for THOP1 Gene COMPARTMENTS Subcellular localization image for THOP1 gene
Compartment Confidence
cytosol 4
mitochondrion 4
extracellular 2
nucleus 2
endoplasmic reticulum 1
plasma membrane 1

No data available for Gene Ontology (GO) - Cellular Components for THOP1 Gene

Pathways & Interactions for THOP1 Gene

genes like me logo Genes that share pathways with THOP1: view

Pathways by source for THOP1 Gene

2 KEGG pathways for THOP1 Gene

Gene Ontology (GO) - Biological Process for THOP1 Gene

None

No data available for SIGNOR curated interactions for THOP1 Gene

Drugs & Compounds for THOP1 Gene

(1) Drugs for THOP1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(2) Additional Compounds for THOP1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with THOP1: view

Transcripts for THOP1 Gene

Unigene Clusters for THOP1 Gene

Thimet oligopeptidase 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for THOP1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c · 10d ^ 11a · 11b ^ 12a · 12b · 12c · 12d ^ 13 ^
SP1: - -
SP2:
SP3: - - - -
SP4: -
SP5:
SP6: -
SP7: - - -
SP8: - -
SP9: - -

ExUns: 14 ^ 15 ^ 16 ^ 17
SP1: - -
SP2:
SP3:
SP4:
SP5: -
SP6:
SP7:
SP8:
SP9:

Relevant External Links for THOP1 Gene

GeneLoc Exon Structure for
THOP1
ECgene alternative splicing isoforms for
THOP1

Expression for THOP1 Gene

mRNA expression in normal human tissues for THOP1 Gene

Protein differential expression in normal tissues from HIPED for THOP1 Gene

This gene is overexpressed in Lymph node (13.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for THOP1 Gene



SOURCE GeneReport for Unigene cluster for THOP1 Gene Hs.78769

genes like me logo Genes that share expression patterns with THOP1: view

Protein tissue co-expression partners for THOP1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for THOP1 Gene

Orthologs for THOP1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for THOP1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia THOP1 35
  • 86.89 (n)
  • 90.5 (a)
THOP1 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia THOP1 35
  • 87.67 (n)
  • 90.2 (a)
THOP1 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Thop1 35
  • 84.24 (n)
  • 89.6 (a)
Thop1 16
Thop1 36
  • 89 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia THOP1 35
  • 96.75 (n)
  • 96.69 (a)
THOP1 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Thop1 35
  • 84.55 (n)
  • 89.04 (a)
oppossum
(Monodelphis domestica)
Mammalia THOP1 36
  • 70 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia THOP1 36
  • 75 (a)
OneToOne
chicken
(Gallus gallus)
Aves LOC426398 35
  • 78.45 (n)
  • 83.28 (a)
THOP1 36
  • 81 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.15329 35
thop1 35
  • 67.02 (n)
  • 74.7 (a)
African clawed frog
(Xenopus laevis)
Amphibia LOC397806 35
zebrafish
(Danio rerio)
Actinopterygii wufb74b01 35
zgc:92139 35
  • 71.96 (n)
  • 76.05 (a)
thop1 36
  • 72 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10066 35
fruit fly
(Drosophila melanogaster)
Insecta CG11771 37
  • 24 (a)
CG11771 36
  • 21 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea ZK550.3 36
  • 17 (a)
OneToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGR406C 35
  • 48.36 (n)
  • 38.58 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PRD1 36
  • 35 (a)
OneToMany
PRD1 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G67690 35
  • 45.28 (n)
  • 35.68 (a)
rice
(Oryza sativa)
Liliopsida Os01g0902200 35
  • 45 (n)
  • 35.79 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.9293 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4245 36
  • 59 (a)
OneToMany
Species with no ortholog for THOP1:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for THOP1 Gene

ENSEMBL:
Gene Tree for THOP1 (if available)
TreeFam:
Gene Tree for THOP1 (if available)

Paralogs for THOP1 Gene

Paralogs for THOP1 Gene

genes like me logo Genes that share paralogs with THOP1: view

Variants for THOP1 Gene

Sequence variations from dbSNP and Humsavar for THOP1 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs732126 -- 2,811,579(+) AACCC(C/T)GCCAT intron-variant
rs759068 -- 2,792,568(+) TAGTG(A/G)CCAGA intron-variant
rs759069 -- 2,792,622(+) TTTTT(A/T)AAAAA intron-variant
rs1736176 -- 2,790,396(+) CGCCC(A/G)GCACT intron-variant
rs1736177 -- 2,791,626(+) CTCCT(C/T)GGCCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for THOP1 Gene

Variant ID Type Subtype PubMed ID
nsv509714 CNV Insertion 20534489
nsv910675 CNV Loss 21882294
dgv3641n71 CNV Loss 21882294
nsv828397 CNV Gain 20364138
dgv3643n71 CNV Loss 21882294
nsv910691 CNV Loss 21882294
nsv910692 CNV Loss 21882294
nsv910693 CNV Loss 21882294
nsv509715 CNV Insertion 20534489
esv2717912 CNV Deletion 23290073
esv1006393 CNV Deletion 20482838
esv2717913 CNV Deletion 23290073
esv1432748 CNV Deletion 17803354
esv1039020 CNV Insertion 17803354

Variation tolerance for THOP1 Gene

Residual Variation Intolerance Score: 14.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.10; 51.03% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for THOP1 Gene

HapMap Linkage Disequilibrium report
THOP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for THOP1 Gene

Disorders for THOP1 Gene

Relevant External Links for THOP1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
THOP1

No disorders were found for THOP1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for THOP1 Gene

Publications for THOP1 Gene

  1. Swapping the substrate specificities of the neuropeptidases neurolysin and thimet oligopeptidase. (PMID: 17251185) Lim E.J. … Rodgers D.W. (J. Biol. Chem. 2007) 3 4 67
  2. Increased expression of the oligopeptidase THOP1 is a neuroprotective response to Abeta toxicity. (PMID: 18571100) Pollio G. … Terstappen G.C. (Neurobiol. Dis. 2008) 3 23
  3. Crystal structure of human thimet oligopeptidase provides insight into substrate recognition, regulation, and localization. (PMID: 14998993) Ray K. … Rodgers D.W. (J. Biol. Chem. 2004) 3 23
  4. Human endopeptidase 24.15 (THOP1) is localized on chromosome 19p13.3 and is excluded from the linkage region for late-onset Alzheimer disease. (PMID: 9790774) Torres M.P. … Lennon G. (Genomics 1998) 2 3
  5. Human thimet oligopeptidase. (PMID: 8373360) Dando P.M. … Barrett A.J. (Biochem. J. 1993) 3 23

Products for THOP1 Gene

Sources for THOP1 Gene

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