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Aliases for THOP1 Gene

Aliases for THOP1 Gene

  • Thimet Oligopeptidase 1 2 3
  • Endopeptidase 24.15 3 4
  • EC 3.4.24.15 4 63
  • MP78 3 4
  • Thimet Oligopeptidase 3
  • MEPD_HUMAN 3
  • EC 3.4.24 63
  • EP24.15 3
  • TOP 3

External Ids for THOP1 Gene

Previous GeneCards Identifiers for THOP1 Gene

  • GC19P002848
  • GC19P002725
  • GC19P002736
  • GC19P002554

Summaries for THOP1 Gene

GeneCards Summary for THOP1 Gene

THOP1 (Thimet Oligopeptidase 1) is a Protein Coding gene. Among its related pathways are Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics and African trypanosomiasis. GO annotations related to this gene include metalloendopeptidase activity and peptide binding. An important paralog of this gene is NLN.

UniProtKB/Swiss-Prot for THOP1 Gene

  • Involved in the metabolism of neuropeptides under 20 amino acid residues long. Involved in cytoplasmic peptide degradation. Able to degrade the beta-amyloid precursor protein and generate amyloidogenic fragments

Gene Wiki entry for THOP1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for THOP1 Gene

Genomics for THOP1 Gene

Regulatory Elements for THOP1 Gene

Genomic Location for THOP1 Gene

Start:
2,785,460 bp from pter
End:
2,815,807 bp from pter
Size:
30,348 bases
Orientation:
Plus strand

Genomic View for THOP1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for THOP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for THOP1 Gene

Proteins for THOP1 Gene

  • Protein details for THOP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P52888-THOP1_HUMAN
    Recommended name:
    Thimet oligopeptidase
    Protein Accession:
    P52888
    Secondary Accessions:
    • B3KSE2
    • Q9UCB3

    Protein attributes for THOP1 Gene

    Size:
    689 amino acids
    Molecular mass:
    78840 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 1 zinc ion per subunit.;
    Quaternary structure:
    • Monomer.

    Three dimensional structures from OCA and Proteopedia for THOP1 Gene

    Alternative splice isoforms for THOP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for THOP1 Gene

Proteomics data for THOP1 Gene at MOPED

Post-translational modifications for THOP1 Gene

  • Ubiquitination at Lys220, Lys239, Lys301, Lys538, and Lys559
  • Modification sites at PhosphoSitePlus

Domains for THOP1 Gene

Protein Domains for THOP1 Gene

Graphical View of Domain Structure for InterPro Entry

P52888

UniProtKB/Swiss-Prot:

THOP1_HUMAN :
  • P52888
Family:
  • Belongs to the peptidase M3 family.
genes like me logo Genes that share domains with THOP1: view

No data available for Gene Families for THOP1 Gene

Function for THOP1 Gene

Molecular function for THOP1 Gene

GENATLAS Biochemistry: Thimet oligopeptidase 1,expressed in brain,homolog of the rat metalloendopeptidase 24.15,involved in antigen presentation via MHC class 1
UniProtKB/Swiss-Prot CatalyticActivity: Preferential cleavage of bonds with hydrophobic residues at P1, P2 and P3 and a small residue at P1 in substrates of 5 to 15 residues
UniProtKB/Swiss-Prot Function: Involved in the metabolism of neuropeptides under 20 amino acid residues long. Involved in cytoplasmic peptide degradation. Able to degrade the beta-amyloid precursor protein and generate amyloidogenic fragments

Enzyme Numbers (IUBMB) for THOP1 Gene

Gene Ontology (GO) - Molecular Function for THOP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004222 metalloendopeptidase activity IEA --
GO:0005515 protein binding IPI 19614740
GO:0008233 peptidase activity --
GO:0042277 peptide binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with THOP1: view

Phenotypes for THOP1 Gene

GenomeRNAi human phenotypes for THOP1:
genes like me logo Genes that share phenotypes with THOP1: view

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for THOP1 Gene

Localization for THOP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for THOP1 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for THOP1 Gene COMPARTMENTS Subcellular localization image for THOP1 gene
Compartment Confidence
cytosol 3
extracellular 2
nucleus 2
endoplasmic reticulum 1
golgi apparatus 1
mitochondrion 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for THOP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with THOP1: view

Pathways for THOP1 Gene

genes like me logo Genes that share pathways with THOP1: view

Pathways by source for THOP1 Gene

2 KEGG pathways for THOP1 Gene

Gene Ontology (GO) - Biological Process for THOP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0006518 peptide metabolic process IEA --
GO:0035556 intracellular signal transduction IEA --
genes like me logo Genes that share ontologies with THOP1: view

Compounds for THOP1 Gene

(6) HMDB Compounds for THOP1 Gene

Compound Synonyms Cas Number PubMed IDs
Dynorphin A (6-8)
  • R-R-I
Not Available
Dynorphin B
  • Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Gln-Phe-Lys-Val-Val-Thr
85006-82-2
Dynorphin B (10-13)
  • Lys-Val-Val-Thr
Not Available
Dynorphin B (6-9)
  • Arg-Arg-Gln-Phe
Not Available
Neuromedin C
  • Gly-Asn-His-Trp-Ala-Val-Gly-His-Leu-Met-NH2
81608-30-2

(3) Novoseek inferred chemical compound relationships for THOP1 Gene

Compound -log(P) Hits PubMed IDs
thimet 95.3 10
gnrh 32.8 1
zinc 17.6 1
genes like me logo Genes that share compounds with THOP1: view

Transcripts for THOP1 Gene

Unigene Clusters for THOP1 Gene

Thimet oligopeptidase 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for THOP1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c · 10d ^ 11a · 11b ^ 12a · 12b · 12c · 12d ^ 13 ^
SP1: - -
SP2:
SP3: - - - -
SP4: -
SP5:
SP6: -
SP7: - - -
SP8: - -
SP9: - -

ExUns: 14 ^ 15 ^ 16 ^ 17
SP1: - -
SP2:
SP3:
SP4:
SP5: -
SP6:
SP7:
SP8:
SP9:

Relevant External Links for THOP1 Gene

GeneLoc Exon Structure for
THOP1
ECgene alternative splicing isoforms for
THOP1

Expression for THOP1 Gene

mRNA expression in normal human tissues for THOP1 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for THOP1 Gene

SOURCE GeneReport for Unigene cluster for THOP1 Gene Hs.78769

genes like me logo Genes that share expressions with THOP1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for THOP1 Gene

Orthologs for THOP1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for THOP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia THOP1 35
  • 96.75 (n)
  • 96.69 (a)
THOP1 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia THOP1 35
  • 86.89 (n)
  • 90.5 (a)
THOP1 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia THOP1 35
  • 87.67 (n)
  • 90.2 (a)
THOP1 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Thop1 35
  • 84.24 (n)
  • 89.6 (a)
Thop1 16
Thop1 36
  • 89 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia THOP1 36
  • 70 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia THOP1 36
  • 75 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Thop1 35
  • 84.55 (n)
  • 89.04 (a)
chicken
(Gallus gallus)
Aves LOC426398 35
  • 78.45 (n)
  • 83.28 (a)
THOP1 36
  • 81 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia LOC397806 35
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.15329 35
thop1 35
  • 67.02 (n)
  • 74.7 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10066 35
zebrafish
(Danio rerio)
Actinopterygii thop1 36
  • 72 (a)
OneToOne
wufb74b01 35
zgc:92139 35
  • 71.96 (n)
  • 76.05 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG11771 36
  • 21 (a)
OneToMany
CG11771 37
  • 24 (a)
worm
(Caenorhabditis elegans)
Secernentea ZK550.3 36
  • 17 (a)
OneToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGR406C 35
  • 48.36 (n)
  • 38.58 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PRD1 36
  • 35 (a)
OneToMany
PRD1 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G67690 35
  • 45.28 (n)
  • 35.68 (a)
rice
(Oryza sativa)
Liliopsida Os01g0902200 35
  • 45 (n)
  • 35.79 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.9293 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4245 36
  • 59 (a)
OneToMany
Species with no ortholog for THOP1:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for THOP1 Gene

ENSEMBL:
Gene Tree for THOP1 (if available)
TreeFam:
Gene Tree for THOP1 (if available)

Paralogs for THOP1 Gene

Paralogs for THOP1 Gene

genes like me logo Genes that share paralogs with THOP1: view

Variants for THOP1 Gene

Sequence variations from dbSNP and Humsavar for THOP1 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs732126 -- 2,811,579(+) AACCC(C/T)GCCAT intron-variant
rs759068 -- 2,792,568(+) TAGTG(A/G)CCAGA intron-variant
rs759069 -- 2,792,622(+) TTTTT(A/T)AAAAA intron-variant
rs941406 -- 2,803,625(+) GATGG(A/G)GAGCT intron-variant
rs941407 -- 2,812,155(+) TCTGG(A/G)GAAGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for THOP1 Gene

Variant ID Type Subtype PubMed ID
nsv509714 CNV Insertion 20534489
nsv910675 CNV Loss 21882294
dgv3641n71 CNV Loss 21882294
nsv828397 CNV Gain 20364138
dgv3643n71 CNV Loss 21882294
nsv910691 CNV Loss 21882294
nsv910692 CNV Loss 21882294
nsv910693 CNV Loss 21882294
nsv509715 CNV Insertion 20534489
esv2717912 CNV Deletion 23290073
esv1006393 CNV Deletion 20482838
esv2717913 CNV Deletion 23290073
esv1432748 CNV Deletion 17803354
esv1039020 CNV Insertion 17803354

Relevant External Links for THOP1 Gene

HapMap Linkage Disequilibrium report
THOP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for THOP1 Gene

Disorders for THOP1 Gene

No disorders were found for THOP1 Gene.

No data available for UniProtKB/Swiss-Prot for THOP1 Gene

Publications for THOP1 Gene

  1. Human thimet oligopeptidase. (PMID: 8373360) Dando P.M. … Barrett A.J. (Biochem. J. 1993) 3 23
  2. Crystal structure of human thimet oligopeptidase provides insight into substrate recognition, regulation, and localization. (PMID: 14998993) Ray K. … Rodgers D.W. (J. Biol. Chem. 2004) 3 23
  3. Increased expression of the oligopeptidase THOP1 is a neuroprotective response to Abeta toxicity. (PMID: 18571100) Pollio G. … Terstappen G.C. (Neurobiol. Dis. 2008) 3 23
  4. Cloning and functional expression of a metalloendopeptidase from human brain with the ability to cleave a beta-APP substrate peptide. (PMID: 7639763) Thompson A. … Malherbe P. (Biochem. Biophys. Res. Commun. 1995) 3 4
  5. Identification of a metalloprotease from Alzheimer's disease brain able to degrade the beta-amyloid precursor protein and generate amyloidogenic fragments. (PMID: 8286339) Papastoitsis G. … Abraham C.R. (Biochemistry 1994) 3 4

Products for THOP1 Gene

Sources for THOP1 Gene

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