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THOP1 Gene

protein-coding   GIFtS: 65
GCID: GC19P002785

Thimet Oligopeptidase 1

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Thimet Oligopeptidase 11 2     MEPD_HUMAN2
Endopeptidase 24.152 3     TOP2
MP782 3     Thimet Oligopeptidase2
EC 3.4.24.153 8     EC 3.4.248
EP24.152     

External Ids:    HGNC: 117931   Entrez Gene: 70642   Ensembl: ENSG000001720097   OMIM: 6011175   UniProtKB: P528883   

Export aliases for THOP1 gene to outside databases

Previous GC identifers: GC19P002848 GC19P002725 GC19P002736 GC19P002554


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for THOP1 Gene:
THOP1 (thimet oligopeptidase 1) is a protein-coding gene. Diseases associated with THOP1 include posterior cerebral artery infarction, and brain stem infarction. GO annotations related to this gene include peptide binding and metalloendopeptidase activity. An important paralog of this gene is NLN.

UniProtKB/Swiss-Prot: THOP1_HUMAN, P52888
Function: Involved in the metabolism of neuropeptides under 20 amino acid residues long. Involved in cytoplasmic
peptide degradation. Able to degrade the beta-amyloid precursor protein and generate amyloidogenic fragments

Gene Wiki entry for THOP1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000019.10  NC_018930.2  NT_011295.12  
Regulatory elements:
   Regulatory transcription factor binding sites in the THOP1 gene promoter:
         CREB   SRY   deltaCREB   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTHOP1 promoter sequence
   Search Chromatin IP Primers for THOP1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat THOP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.3   Ensembl cytogenetic band:  19p13.3   HGNC cytogenetic band: 19p13.3

THOP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
THOP1 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P002785:  view genomic region     (about GC identifiers)

Start:
2,785,458 bp from pter      End:
2,813,599 bp from pter
Size:
28,142 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: THOP1_HUMAN, P52888 (See protein sequence)
Recommended Name: Thimet oligopeptidase  
Size: 689 amino acids; 78840 Da
Cofactor: Binds 1 zinc ion per subunit
Subunit: Monomer (By similarity)
2 PDB 3D structures from and Proteopedia for THOP1:
1S4B (3D)        2O36 (3D)    
Secondary accessions: Q9UCB3

Explore the universe of human proteins at neXtProt for THOP1: NX_P52888

Explore proteomics data for THOP1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys220, Lys239, Lys301, Lys538, Lys559
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for THOP1 (P52888) (see all 24)
     VERDFVE  ASTEADK  RNGLHLP  LDFPQHVS 


    See THOP1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_003240.1  
    ENSEMBL proteins: 
     ENSP00000304467   ENSP00000465545   ENSP00000467226   ENSP00000466653   ENSP00000465855  
     ENSP00000465895   ENSP00000378638   ENSP00000464786  

    THOP1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins for THOP1
    OriGene Protein Over-expression Lysate for THOP1
    OriGene MassSpec for THOP1
    OriGene Custom Protein Services for THOP1
    GenScript Custom Purified and Recombinant Proteins Services for THOP1
    Novus Biologicals THOP1 Proteins
    Novus Biologicals THOP1 Lysate
    Sino Biological Recombinant Protein for THOP1
    Sino Biological Cell Lysate for THOP1
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for THOP1

    THOP1 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of THOP1
    R&D Systems Antibodies for THOP1 (Thimet Oligopeptidase/THOP1)
    OriGene Antibodies for THOP1
    OriGene Custom Antibody Services for THOP1
    Novus Biologicals THOP1 Antibodies
    Abcam antibodies for THOP1
    Cloud-Clone Corp. Antibodies for THOP1
    ThermoFisher Antibodies for THOP1
    LSBio Antibodies in human, mouse, rat for THOP1

    THOP1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for THOP1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for THOP1
    Cloud-Clone Corp. CLIAs for THOP1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR024079 MetalloPept_cat_dom
     IPR024077 Neurolysin/TOP_dom2
     IPR001567 Pept_M3A_M3B
     IPR024080 Neurolysin/TOP_N

    Graphical View of Domain Structure for InterPro Entry P52888

    ProtoNet protein and cluster: P52888

    1 Blocks protein domain: IPB001567 Peptidase M3

    UniProtKB/Swiss-Prot: THOP1_HUMAN, P52888
    Similarity: Belongs to the peptidase M3 family


    THOP1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: THOP1_HUMAN, P52888
    Function: Involved in the metabolism of neuropeptides under 20 amino acid residues long. Involved in cytoplasmic
    peptide degradation. Able to degrade the beta-amyloid precursor protein and generate amyloidogenic fragments
    Catalytic activity: Preferential cleavage of bonds with hydrophobic residues at P1, P2 and P3' and a small residue
    at P1' in substrates of 5 to 15 residues

         Genatlas biochemistry entry for THOP1:
    Thimet oligopeptidase 1,expressed in brain,homolog of the rat metalloendopeptidase 24.15,involved in antigen
    presentation via MHC class 1

         Enzyme Numbers (IUBMB): EC 3.4.24.151 2 EC 3.4.242

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004222metalloendopeptidase activity IEA--
    GO:0005515protein binding IPI19614740
    GO:0008233peptidase activity ----
    GO:0042277peptide binding IEA--
    GO:0046872metal ion binding IEA--
         
    THOP1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for THOP1:
     Decreased viability 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for THOP1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for THOP1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for THOP1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for THOP1

    miRNA
    Products:
        
    miRTarBase miRNAs that target THOP1:
    hsa-mir-222-3p (MIRT046579), hsa-mir-24-3p (MIRT030367), hsa-mir-215-5p (MIRT024285), hsa-mir-130b-3p (MIRT020122), hsa-mir-484 (MIRT041826), hsa-mir-425-5p (MIRT039328), hsa-mir-19b-3p (MIRT031093), hsa-mir-615-3p (MIRT040074), hsa-mir-505-3p (MIRT041034), hsa-mir-192-5p (MIRT026106), hsa-mir-935 (MIRT036680)

    Block miRNA regulation of human, mouse, rat THOP1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate THOP1 (see all 11):
    hsa-miR-301b hsa-miR-3910 hsa-miR-301a hsa-miR-3666 hsa-miR-124 hsa-miR-454 hsa-miR-4295 hsa-miR-506
    SwitchGear 3'UTR luciferase reporter plasmidTHOP1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for THOP1
    Predesigned siRNA for gene silencing in human, mouse, rat THOP1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for THOP1

    Clone
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    OriGene clones in human, mouse for THOP1 (see all 8)
    OriGene ORF clones in mouse, rat for THOP1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: THOP1 (NM_003249)
    Sino Biological Human cDNA Clone for THOP1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for THOP1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat THOP1

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for THOP1
    Browse ESI BIO Cell Lines and PureStem Progenitors for THOP1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for THOP1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    THOP1_HUMAN, P52888: Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    extracellular2
    nucleus2
    endoplasmic reticulum1
    golgi apparatus1
    mitochondrion1
    plasma membrane1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--

    THOP1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for THOP1 About    
    See pathways by source

    SuperPathContained pathways About
    1Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics
    Renin-angiotensin system0.37
    2Selected targets of GCR alpha
    Selected targets of GCR alpha
    3African trypanosomiasis
    African trypanosomiasis

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways




    2 Kegg Pathways  (Kegg details for THOP1):
        Renin-angiotensin system
    African trypanosomiasis


    THOP1 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for THOP1
    Interactions:

        GeneGlobe Interaction Network for THOP1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 15)

    Selected Interacting proteins for THOP1 (P528881, 2, 3 ENSP000003044674) via UniProtKB, MINT, STRING, and/or I2D (see all 24)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CALM2P621582, 3MINT-7148437 I2D: score=1 
    CALM3P621582, 3MINT-7148437 I2D: score=1 
    CALM1P621582, 3, ENSP000003494674MINT-7148437 I2D: score=1 STRING: ENSP00000349467
    MPP6Q9NZW53, ENSP000002226444I2D: score=2 STRING: ENSP00000222644
    PRKACAP176123, ENSP000003095914I2D: score=2 STRING: ENSP00000309591
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis ----
    GO:0006518peptide metabolic process IEA--

    THOP1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for THOP1

    6 HMDB Compounds for THOP1    About this table
    CompoundSynonyms CAS #PubMed Ids
    Dynorphin A (6-8)R-R-I;RRI;Arg-Arg-Ile ----
    Dynorphin BTyr-Gly-Gly-Phe-Leu-Arg-Arg-Gln-Phe-Lys-Val-Val-Thr;rimorphin;prodynorphin 228-240 85006-82-2--
    Dynorphin B (10-13)Lys-Val-Val-Thr ----
    Dynorphin B (6-9)Arg-Arg-Gln-Phe ----
    Neuromedin CGly-Asn-His-Trp-Ala-Val-Gly-His-Leu-Met-NH2;NMC 81608-30-2--
    Neuromedin C 1-8GRP (18-25);gastrin releasing peptide (18-25);NMC1-8 157623-03-5--

    3 Novoseek inferred chemical compound relationships for THOP1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    thimet 95.3 11 8373360 (3), 18571100 (1), 12706825 (1), 14998993 (1) (see all 8)
    gnrh 32.8 3 12384185 (1)
    zinc 17.6 1 7957888 (1)



    THOP1 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for THOP1 gene: 
    NM_003249.3  

    Unigene Cluster for THOP1:

    Thimet oligopeptidase 1
    Hs.78769  [show with all ESTs]
    Unigene Representative Sequence: BC067281
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000307741(uc002lwj.3 uc010xgz.2) ENST00000585673 ENST00000585338
    ENST00000586780 ENST00000586677 ENST00000589087 ENST00000591149 ENST00000590533
    ENST00000591363 ENST00000590970 ENST00000587401 ENST00000395212(uc002lwk.3)
    ENST00000592639 ENST00000587468

    miRNA
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    Block miRNA regulation of human, mouse, rat THOP1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate THOP1 (see all 11):
    hsa-miR-301b hsa-miR-3910 hsa-miR-301a hsa-miR-3666 hsa-miR-124 hsa-miR-454 hsa-miR-4295 hsa-miR-506
    SwitchGear 3'UTR luciferase reporter plasmidTHOP1 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for THOP1
    Predesigned siRNA for gene silencing in human, mouse, rat THOP1
    Clone
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    OriGene clones in human, mouse for THOP1 (see all 8)
    OriGene ORF clones in mouse, rat for THOP1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: THOP1 (NM_003249)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for THOP1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat THOP1
    Primer
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    OriGene qPCR primer pairs and template standards for THOP1
    OriGene qSTAR qPCR primer pairs in human, mouse for THOP1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat THOP1
      QuantiTect SYBR Green Assays in human, mouse, rat THOP1
      QuantiFast Probe-based Assays in human, mouse, rat THOP1

    Additional mRNA sequence: 

    AK093392.1 AK300552.1 BC000135.2 BC000583.2 BC002391.2 BC013878.2 BC067281.1 BC150150.1 
    U29366.1 Z50115.1 

    12 DOTS entries:

    DT.113148  DT.100805785  DT.100029471  DT.92442224  DT.100797035  DT.100800951  DT.92442242  DT.92442225 
    DT.92442246  DT.100797043  DT.92442245  DT.99968783 

    Selected AceView cDNA sequences (see all 285):

    BM547663 BM766760 BI870662 BI757339 BQ641377 AI695886 AI611701 AW501845 
    BU859040 BU543715 CN480360 AI184664 AX748095 NM_003249 BU152989 AW009713 
    AW192515 BU195253 BX385668 BU902832 BM757116 AI640563 BM727401 BM055142 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for THOP1 (see all 9)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c · 10d ^ 11a · 11b ^ 12a · 12b · 12c · 12d ^ 13 ^
    SP1:        -                                                                                                                       -                           
    SP2:                                                                                                                                                            
    SP3:        -           -     -     -                                                                                                                           
    SP4:                                                                                                                                -                           
    SP5:                                                                                                                                                            

    ExUns: 14 ^ 15 ^ 16 ^ 17
    SP1:        -     -         
    SP2:                        
    SP3:                        
    SP4:                        
    SP5:        -               


    ECgene alternative splicing isoforms for THOP1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    THOP1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTGAGGCGCT
    THOP1 Expression
    About this image

    THOP1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    THOP1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.78769
        Custom PCR Arrays for THOP1
    Primer
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    OriGene qPCR primer pairs and template standards for THOP1
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    QuantiTect SYBR Green Assays in human, mouse, rat THOP1
    QuantiFast Probe-based Assays in human, mouse, rat THOP1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for THOP1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for THOP1 gene from Selected species (see all 20)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Thop11 , 5 thimet oligopeptidase 11, 5 84.24(n)1
    89.6(a)1
      10 (39.72 cM)5
    504921  NM_022653.41  NP_073144.31 
     810700355 
    chicken
    (Gallus gallus)
    Aves LOC4263981 thimet oligopeptidase-like 78.45(n)
    83.28(a)
      426398  XM_004948886.1  XP_004948943.1 
    African clawed frog
    (Xenopus laevis)
    Amphibia LOC3978062 thimet oligopeptidase 74.57(n)    AB030904.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufb74b012 wufb74b01 77.39(n)   322818  CA473927.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG117713 oligopeptidase A 24(a)   96B10   --
    worm
    (Caenorhabditis elegans)
    Secernentea ZK550.36
    Protein ZK550.3 (ZK550.3) mRNA, complete cds
    17(a)
    1 → many
    IV(17250131-17254964) WBGene00013997
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes PRD1(YCL057W)4 Zinc metalloendopeptidase, found in the cytoplasm and more   --   3(24768-26906) 850301  NP_009874.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT1G676901 AT1G67690 45.28(n)
    35.68(a)
      843094  NM_105437.4  NP_564902.4 
    rice
    (Oryza sativa)
    Liliopsida Os01g09022001 Os01g0902200 45(n)
    35.79(a)
      4325012  NM_001051651.1  NP_001045116.1 


    ENSEMBL Gene Tree for THOP1 (if available)
    TreeFam Gene Tree for THOP1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for THOP1 gene
    NLN2  
    2 SIMAP similar genes for THOP1 using alignment to 10 protein entries:     THOP1_HUMAN (see all proteins):
    DKFZp564F123    NLN

    THOP1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for THOP1 (see all 868)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs20710151,2
    C,F,H--2785376(+) ACCAAT/CAACGG 1 -- us2k1 tfbs312Minor allele frequency- C:0.07NS EA NA 1500
    rs784012241,2
    C,F--2785434(+) GCCCTC/TCTCCT 1 -- us2k11Minor allele frequency- T:0.03WA 118
    rs1884086411,2
    --2785618(+) GTAGCA/TGGTGG 1 -- ut510--------
    rs1482078381,2
    --2785781(+) GCCACC/TCTCGG 1 -- int10--------
    rs1930391841,2
    --2785915(+) TCGGGC/TCCCGT 1 -- int10--------
    rs1402130421,2
    --2785954(+) CGACTC/TCAGTC 1 -- int10--------
    rs1839627191,2
    --2785976(+) GAATTC/TTAGAG 1 -- int10--------
    rs573880671,2
    C,F--2786015(+) AGAGAG/AGATCG 1 -- int12Minor allele frequency- A:0.03WA 120
    rs1502899001,2
    --2786047(+) TCTGGC/TGCAGA 1 -- int10--------
    rs1877993681,2
    --2786096(+) AGAGAC/GGGTGG 1 -- int10--------

    HapMap Linkage Disequilibrium report for THOP1 (2785458 - 2813599 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for THOP1 (see all 14):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2717913CNV Deletion23290073
    esv1006393CNV Deletion20482838
    esv1432748CNV Deletion17803354
    esv2717912CNV Deletion23290073
    nsv509715CNV Insertion20534489
    nsv509714CNV Insertion20534489
    esv1039020CNV Insertion17803354
    nsv910691CNV Loss21882294
    nsv910693CNV Loss21882294
    nsv910692CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing THOP1
    DNA2.0 Custom Variant and Variant Library Synthesis for THOP1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601117    OMIM disorders: --

    7 diseases for THOP1:    
    About MalaCards
    posterior cerebral artery infarction    brain stem infarction    ureterolithiasis    trypanosomiasis
    cerebritis    alzheimer's disease    endotheliitis


    THOP1 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    Export disorders for THOP1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for THOP1 gene, integrated from 10 sources (see all 50):
    (articles sorted by number of sources associating them with THOP1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Swapping the substrate specificities of the neuropeptidases neurolysin and thimet oligopeptidase. (PubMed id 17251185)1, 2 Lim E.J....Rodgers D.W. (J. Biol. Chem. 2007)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)1, 2 Grimwood J.... Lucas S.M. (Nature 2004)
    4. Human endopeptidase 24.15 (THOP1) is localized on chromosome 19p13.3 and is excluded from the linkage region for late-onset Alzheimer disease. (PubMed id 9790774)1, 3 Torres M.P....Lennon G. (Genomics 1998)
    5. Cloning and functional expression of a metalloendopeptidase from human brain with the ability to cleave a beta-APP substrate peptide. (PubMed id 7639763)1, 2 Thompson A.... Malherbe P. (Biochem. Biophys. Res. Commun. 1995)
    6. Identification of a metalloprotease from Alzheimer's disease brain able to degrade the beta-amyloid precursor protein and generate amyloidogenic fragments. (PubMed id 8286339)1, 2 Papastoitsis G.... Abraham C.R. (Biochemistry 1994)
    7. Increased expression of the oligopeptidase THOP1 is a neuroprotective response to Abeta toxicity. (PubMed id 18571100)1, 9 Pollio G....Terstappen G.C. (Neurobiol. Dis. 2008)
    8. Human thimet oligopeptidase. (PubMed id 8373360)1, 9 Dando P.M....Barrett A.J. (Biochem. J. 1993)
    9. Crystal structure of human thimet oligopeptidase provides insight into substrate recognition, regulation, and localization. (PubMed id 14998993)1, 9 Ray K....Rodgers D.W. (J. Biol. Chem. 2004)
    10. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 7064 HGNC: 11793 AceView: THOP1 Ensembl:ENSG00000172009 euGenes: HUgn7064
    ECgene: THOP1 Kegg: 7064 H-InvDB: THOP1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for THOP1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for THOP1 gene:
    Search GeneIP for patents involving THOP1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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