THOC7 Gene
protein-coding GIFtS: 49
GCID: GC03M063795
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|
THO complex 7 homolog (Drosophila)
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Aliases
for THOC7 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| THO Complex 7 Homolog (Drosophila)1 2 | | HTREX301 | | NIF3L1BP11 2 3 5 | | NIF3L1-Binding Protein 12 3 | | FSAP241 | | FLJ234451 | | Functional Spliceosome-Associated Protein 242 3 | | Ngg1 Interacting Factor 3 Like 1 Binding Protein 12 | | Ngg1-Interacting Factor 3-Like Protein 1-Binding Protein 12 3 | | THO Complex Subunit 7 Homolog2 |
Export aliases for THOC7 gene to outside databases |
Summaries
for THOC7 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: THOC7_HUMAN, Q6I9Y2Function: Component of the THO subcomplex of the TREX complex. The TREX complex specifically associates with splicedmRNA and not with unspliced pre-mRNA. It is recruited to spliced mRNAs by a transcription-independent mechanism. Bindsto mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to aregion near the 5' end of the mRNA where it functions in mRNA export. The recruitment occurs via an interactionbetween ALYREF/THOC4 and the cap-binding protein NCBP1. DDX39B functions as a bridge between ALYREF/THOC4 and the THOcomplex. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronlessmRNAs and infectious virus production. The recruitment of the TREX complex to the intronless viral mRNA occurs via aninteraction between KSHV ORF57 protein and ALYREF/THOC4
|
Genomic Views
for THOC7 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000003.11 NC_018914.1 NT_022517.18
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the THOC7 gene promoter:
TBP PPAR-gamma1 POU2F1a TFIID PPAR-gamma2 FOXL1 GATA-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for THOC7
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat THOC7 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 3p14.1 Ensembl cytogenetic band: 3p14.1 HGNC cytogenetic band: 3p14.1THOC7 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 3 GeneLoc Exon Structure GeneLoc location for GC03M063795: view genomic region
(about GC identifiers)
Start:
|
63,819,546 bp from pter |
End:
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63,849,597 bp from pter |
Size:
|
30,052 bases |
Orientation:
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minus strand |
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Proteins
for THOC7 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: THOC7_HUMAN, Q6I9Y2 (See
protein sequence)Recommended Name: THO complex subunit 7 homolog Size: 204 amino acids; 23743 Da
Subunit: Component of the THO complex, which is composed of THOC1, THOC2, THOC5, THOC6 and THOC7. Together with THOC3,ALYREF/THOC4 and DDX39B, THO forms the transcription/export (TREX) complex. Interacts with NIF3L1 and THOC5
Subcellular location: Cytoplasm. Nucleus. Note=Interaction with THOC5 is required for nuclear localization
Secondary accessions: Q6P1L3 Q8WUF2 Q9H5H0Explore the universe of human proteins at neXtProt for THOC7: NX_Q6I9Y2
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q6I9Y2
THOC7 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_079351.2
ENSEMBL proteins: ENSP00000295899 ENSP00000418518 ENSP00000419682 ENSP00000419443
Human Recombinant Protein Products:
Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table
THOC7 for ontologies About GeneDecksing
THOC7 Antibody Products:
Assay Products for THOC7: |
Protein
Domains /
Families
for THOC7 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
THOC7 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q6I9Y2ProtoNet protein and cluster: Q6I9Y2 UniProtKB/Swiss-Prot: THOC7_HUMAN, Q6I9Y2Similarity: Belongs to the THOC7 family |
Function
for THOC7 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: THOC7_HUMAN, Q6I9Y2Function: Component of the THO subcomplex of the TREX complex. The TREX complex specifically associates with splicedmRNA and not with unspliced pre-mRNA. It is recruited to spliced mRNAs by a transcription-independent mechanism. Bindsto mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to aregion near the 5' end of the mRNA where it functions in mRNA export. The recruitment occurs via an interactionbetween ALYREF/THOC4 and the cap-binding protein NCBP1. DDX39B functions as a bridge between ALYREF/THOC4 and the THOcomplex. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronlessmRNAs and infectious virus production. The recruitment of the TREX complex to the intronless viral mRNA occurs via aninteraction between KSHV ORF57 protein and ALYREF/THOC4
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for THOC7 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for THOC7
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: THOC7 (NM_025075) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for THOC7 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat THOC7 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for THOC7 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table
THOC7 for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for THOC7:
|
Pathways & Interactions
for THOC7 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | RNA transport | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 
Kegg Pathway (Kegg details for THOC7):
THOC7 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for THOC7
STRING Interaction
Network Preview (showing 5 interactants - click image to see 18)
5/21 Interacting proteins for THOC7 (Q6I9Y22, 3 ENSP000002958994) via UniProtKB, MINT, STRING, and/or I2D (see all 21)About this table
Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table
THOC7 for ontologies About GeneDecksing
|
Drugs & Compounds
for THOC7 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for THOC7
Search CenterWatch for drugs/clinical trials and news about THOC7
|
Transcripts
for THOC7 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for THOC7 gene: NM_025075.2 Unigene Cluster for THOC7: THO complex 7 homolog (Drosophila) Hs.288151 [show with all ESTs]Unigene Representative Sequence: BF7902837 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000295899(uc003dlt.4 uc003dlu.4) ENST00000469584 ENST00000473141
ENST00000469153 ENST00000498422 ENST00000464327 ENST00000487570
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for THOC7 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for THOC7
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: THOC7 (NM_025075) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for THOC7 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat THOC7 |
Additional cDNA sequence: AK027098.1 AK225110.1 BC020599.2 BC065012.1 CR457373.1 6 DOTS entries: DT.447610 DT.95170210 DT.100774161 DT.100735002 DT.120885739 DT.120885691 24/152 AceView cDNA sequences (see all 152): CB121868 AA782524 BE884407 BU660275 CB528375 BU167522 N25170 AI273401 AI298428 BF831844 H98650 BI758998 BQ018944 AI085280 BQ271383 CA313791 AI242257 BI544790 AA441936 BM700193 T93541 AA922295 AI022961 AI869248
GeneLoc Exon Structure
|
Expression
for THOC7 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| THOC7 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ACCATAATGT
About this image
See THOC7 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for THOC7
SOURCE GeneReport for Unigene cluster: Hs.288151
SABiosciences Custom PCR Arrays for THOC7
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for THOC7
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat THOC7 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat THOC7 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat THOC7 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for THOC7 |
Orthologs
for THOC7 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for THOC7 gene from 9/27 species (see all 27) About this table
ENSEMBL Gene Tree for THOC7 (if available)
TreeFam Gene Tree for THOC7 (if available) |
Paralogs
for THOC7 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for THOC7 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 3 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for THOC7 (63819546 - 63849597 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for THOC7: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing THOC7 |
|
Disorders
/ Diseases
for THOC7 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
THOC7 for disorders About GeneDecksing
OMIM gene information: 611965
OMIM disorders: --
3  diseases for THOC7: About MalaCardskaposi's sarcoma sarcoma breast cancer
Human Genome Epidemiology (HuGE) Navigator: THOC7 (1 document)
Export disorders for THOC7 gene to outside databases
|
Publications
for THOC7 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for THOC7 gene, integrated from 9 sources (see all 23):
(articles sorted by number of sources associating them with THOC7) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Identification and characterization of NIF3L1 BP1, a novel cytoplasmic interaction partner of the NIF3L1 protein. (PubMed id 12951069)1, 2, 3 Tascou S.... Burfeind P. (2003)
- Nuclear localization of the pre-mRNA associating protein THOC7 depends upon its direct interaction with Fms tyrosine kinase interacting protein (FMIP). (PubMed id 19059247)1, 2 El Bounkari O.... Tamura T. (2009)
- Recruitment of the complete hTREX complex is required for Kaposi's sarcoma-associated herpesvirus intronless mRNA nuclear export and virus replication. (PubMed id 18974867)1, 2 Boyne J.R.... Whitehouse A. (2008)
- Human mRNA export machinery recruited to the 5' end of mRNA. (PubMed id 17190602)1, 2 Cheng H.... Reed R. (2006)
- Recruitment of the human TREX complex to mRNA during splicing. (PubMed id 15998806)1, 2 Masuda S.... Reed R. (2005)
- Linking transcriptional elongation and messenger RNA export to metastatic breast cancers. (PubMed id 15833825)1, 2 Guo S.... Shiekhattar R. (2005)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
|
External Searches for THOC7 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing THOC7 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing THOC7 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing THOC7 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for THOC7 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for THOC7 gene:
Search GeneIP for patents involving THOC7
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for THOC7 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat THOC7 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing THOC7 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat THOC7 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat THOC7 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat THOC7 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat THOC7 |
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 | | | THOC7 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for THOC7 |
|  |  |  | | | | ThermoFisher Antibodies for THOC7 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat THOC7 |
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