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Aliases for THOC7 Gene

Aliases for THOC7 Gene

  • THO Complex 7 2 3 5
  • Functional Spliceosome-Associated Protein 24 2 3 4
  • Ngg1-Interacting Factor 3-Like Protein 1-Binding Protein 1 3 4
  • Ngg1 Interacting Factor 3 Like 1 Binding Protein 1 2 3
  • NIF3L1-Binding Protein 1 3 4
  • NIF3L1BP1 3 4
  • HTREX30 3 4
  • FSAP24 3 4
  • THO Complex 7 Homolog (Drosophila) 2
  • THO Complex Subunit 7 Homolog 3
  • THO Complex 7 Homolog 3

External Ids for THOC7 Gene

Summaries for THOC7 Gene

GeneCards Summary for THOC7 Gene

THOC7 (THO Complex 7) is a Protein Coding gene. Among its related pathways are Formation of HIV elongation complex in the absence of HIV Tat and RNA Polymerase II Transcription Termination. GO annotations related to this gene include RNA binding.

UniProtKB/Swiss-Prot for THOC7 Gene

  • Required for efficient export of polyadenylated RNA. Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5 end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway.

  • The TREX complex is essential for the export of Kaposis sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production.

Additional gene information for THOC7 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for THOC7 Gene

Genomics for THOC7 Gene

Regulatory Elements for THOC7 Gene

Enhancers for THOC7 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03H063975 1.3 Ensembl ENCODE dbSUPER 16.5 -114.6 -114645 8 SOX13 PKNOX1 SAP130 ZSCAN4 MAX FEZF1 CEBPG POLR2A FOS MAFK ATXN7 PSMD6-AS2 THOC7 THOC7-AS1 ENSG00000280620
GH03H063910 1.3 ENCODE dbSUPER 12.4 -48.3 -48254 3 FOXA2 ATF1 ARID4B SIN3A YY1 GLIS2 ZNF143 ZNF207 ATF7 SP3 PSMD6-AS2 THOC7 ATXN7 THOC7-AS1 LOC100130345 ADAMTS9-AS2 ENSG00000280620
GH03H063966 1.4 Ensembl ENCODE dbSUPER 11.2 -105.5 -105498 7 PKNOX1 ARID4B DMAP1 ZNF2 YY1 ZNF766 ZNF143 ATF7 RUNX3 SP3 PSMD6-AS2 THOC7 THOC7-AS1 ATXN7 ENSG00000280620
GH03H063959 1.4 Ensembl ENCODE dbSUPER 11.2 -96.1 -96118 1 HDAC1 RAD21 ZNF2 ZNF366 FOS USF2 REST ZEB2 ELF1 ZNF518A THOC7 THOC7-AS1 ATXN7 PSMD6-AS2 ENSG00000280620
GH03H063937 1.3 Ensembl ENCODE dbSUPER 11.4 -73.5 -73546 1 PKNOX1 TFAP4 TAL1 CEBPG POLR2A ZSCAN5C ZNF143 ATF7 RCOR1 RUNX3 THOC7 ATXN7 THOC7-AS1 PSMD6-AS2 ENSG00000280620
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around THOC7 on UCSC Golden Path with GeneCards custom track

Promoters for THOC7 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000153617 199 2401 TBP HDGF PKNOX1 RB1 ARNT SIN3A ZNF76 DNMT3B ZNF2 GLIS2

Genomic Location for THOC7 Gene

Chromosome:
3
Start:
63,833,870 bp from pter
End:
63,864,399 bp from pter
Size:
30,530 bases
Orientation:
Minus strand

Genomic View for THOC7 Gene

Genes around THOC7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
THOC7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for THOC7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for THOC7 Gene

Proteins for THOC7 Gene

  • Protein details for THOC7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6I9Y2-THOC7_HUMAN
    Recommended name:
    THO complex subunit 7 homolog
    Protein Accession:
    Q6I9Y2
    Secondary Accessions:
    • Q6P1L3
    • Q8WUF2
    • Q9H5H0

    Protein attributes for THOC7 Gene

    Size:
    204 amino acids
    Molecular mass:
    23743 Da
    Quaternary structure:
    • Component of the THO complex, which is composed of THOC1, THOC2, THOC3, THOC5, THOC6 and THOC7; together with at least ALYREF/THOC4, DDX39B, SARNP/CIP29 and CHTOP, THO forms the transcription/export (TREX) complex which seems to have a dynamic structure involving ATP-dependent remodeling. Interacts with NIF3L1 and THOC5.

neXtProt entry for THOC7 Gene

Post-translational modifications for THOC7 Gene

  • Ubiquitination at posLast=3232 and Lys36
  • Modification sites at PhosphoSitePlus

Other Protein References for THOC7 Gene

No data available for DME Specific Peptides for THOC7 Gene

Domains & Families for THOC7 Gene

Gene Families for THOC7 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for THOC7 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for THOC7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6I9Y2

UniProtKB/Swiss-Prot:

THOC7_HUMAN :
  • Belongs to the THOC7 family.
Family:
  • Belongs to the THOC7 family.
genes like me logo Genes that share domains with THOC7: view

Function for THOC7 Gene

Molecular function for THOC7 Gene

UniProtKB/Swiss-Prot Function:
Required for efficient export of polyadenylated RNA. Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5 end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway.
UniProtKB/Swiss-Prot Function:
The TREX complex is essential for the export of Kaposis sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production.

Phenotypes From GWAS Catalog for THOC7 Gene

Gene Ontology (GO) - Molecular Function for THOC7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IEA --
GO:0005515 protein binding IPI 12951069
genes like me logo Genes that share ontologies with THOC7: view
genes like me logo Genes that share phenotypes with THOC7: view

Animal Model Products

CRISPR Products

miRNA for THOC7 Gene

miRTarBase miRNAs that target THOC7

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for THOC7
  • Applied Biological Materials Clones for THOC7
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for THOC7 Gene

Localization for THOC7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for THOC7 Gene

Cytoplasm. Nucleus. Nucleus speckle. Note=Interaction with THOC5 is required for nuclear localization. {ECO:0000269 PubMed:19059247}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for THOC7 gene
Compartment Confidence
nucleus 5
cytosol 5

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nuclear speckles (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for THOC7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000346 transcription export complex IDA 15833825
GO:0000347 THO complex IDA 15998806
GO:0000445 THO complex part of transcription export complex IEA,IDA 15998806
GO:0000784 colocalizes_with nuclear chromosome, telomeric region IDA 24270157
GO:0005634 nucleus IEA,IDA 12951069
genes like me logo Genes that share ontologies with THOC7: view

Pathways & Interactions for THOC7 Gene

genes like me logo Genes that share pathways with THOC7: view

Gene Ontology (GO) - Biological Process for THOC7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006369 termination of RNA polymerase II transcription TAS --
GO:0006397 mRNA processing IEA --
GO:0006405 RNA export from nucleus TAS --
GO:0006406 mRNA export from nucleus TAS --
GO:0006810 transport IEA --
genes like me logo Genes that share ontologies with THOC7: view

No data available for SIGNOR curated interactions for THOC7 Gene

Drugs & Compounds for THOC7 Gene

No Compound Related Data Available

Transcripts for THOC7 Gene

Unigene Clusters for THOC7 Gene

THO complex 7 homolog (Drosophila):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for THOC7
  • Applied Biological Materials Clones for THOC7
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for THOC7 Gene

No ASD Table

Relevant External Links for THOC7 Gene

GeneLoc Exon Structure for
THOC7
ECgene alternative splicing isoforms for
THOC7

Expression for THOC7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for THOC7 Gene

Protein differential expression in normal tissues from HIPED for THOC7 Gene

This gene is overexpressed in Liver (48.7) and Monocytes (7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for THOC7 Gene



Protein tissue co-expression partners for THOC7 Gene

NURSA nuclear receptor signaling pathways regulating expression of THOC7 Gene:

THOC7

SOURCE GeneReport for Unigene cluster for THOC7 Gene:

Hs.288151

Evidence on tissue expression from TISSUES for THOC7 Gene

  • Intestine(4.3)
  • Skin(4.3)
  • Nervous system(2.9)
genes like me logo Genes that share expression patterns with THOC7: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for THOC7 Gene

Orthologs for THOC7 Gene

This gene was present in the common ancestor of animals.

Orthologs for THOC7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia THOC7 33 34
  • 100 (n)
cow
(Bos Taurus)
Mammalia -- 34
  • 100 (a)
OneToMany
THOC7 34
  • 100 (a)
OneToMany
dog
(Canis familiaris)
Mammalia THOC7 33 34
  • 92.9 (n)
mouse
(Mus musculus)
Mammalia Thoc7 33 16 34
  • 91.01 (n)
oppossum
(Monodelphis domestica)
Mammalia THOC7 34
  • 91 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Thoc7 33
  • 88.89 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia THOC7 34
  • 40 (a)
OneToOne
chicken
(Gallus gallus)
Aves THOC7 33 34
  • 81.12 (n)
lizard
(Anolis carolinensis)
Reptilia THOC7 34
  • 83 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia thoc7 33
  • 79.25 (n)
Nif3l1bp1-prov 33
African clawed frog
(Xenopus laevis)
Amphibia nif3l1bp1-prov 33
zebrafish
(Danio rerio)
Actinopterygii thoc7 33 34
  • 73.03 (n)
wufa20e08 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003870 33
  • 47.93 (n)
fruit fly
(Drosophila melanogaster)
Insecta thoc7 33 34
  • 47.64 (n)
worm
(Caenorhabditis elegans)
Secernentea B0513.2 34
  • 23 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.685 34
  • 45 (a)
OneToOne
Species where no ortholog for THOC7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for THOC7 Gene

ENSEMBL:
Gene Tree for THOC7 (if available)
TreeFam:
Gene Tree for THOC7 (if available)

Paralogs for THOC7 Gene

No data available for Paralogs for THOC7 Gene

Variants for THOC7 Gene

Sequence variations from dbSNP and Humsavar for THOC7 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1000039641 -- 63,856,130(+) TATAC(A/G)CACTG intron-variant
rs1000074512 -- 63,835,748(+) TTTGA(A/C)TCTTA intron-variant
rs1000120340 -- 63,848,844(+) AAAGC(C/T)ATCTA intron-variant, downstream-variant-500B
rs1000126641 -- 63,836,040(+) GAAAT(G/T)CAATA intron-variant
rs1000312104 -- 63,861,860(+) CGATC(C/T)TGGCT intron-variant, downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for THOC7 Gene

Variant ID Type Subtype PubMed ID
nsv1008751 CNV gain 25217958
nsv1072696 CNV deletion 25765185
nsv1118973 CNV deletion 24896259

Variation tolerance for THOC7 Gene

Residual Variation Intolerance Score: 28.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.51; 11.03% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for THOC7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
THOC7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for THOC7 Gene

Disorders for THOC7 Gene

Relevant External Links for THOC7

Genetic Association Database (GAD)
THOC7
Human Genome Epidemiology (HuGE) Navigator
THOC7
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
THOC7

No disorders were found for THOC7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for THOC7 Gene

Publications for THOC7 Gene

  1. Recruitment of the human TREX complex to mRNA during splicing. (PMID: 15998806) Masuda S … Reed R (Genes & development 2005) 2 3 4 60
  2. Identification and characterization of NIF3L1 BP1, a novel cytoplasmic interaction partner of the NIF3L1 protein. (PMID: 12951069) Tascou S … Burfeind P (Biochemical and biophysical research communications 2003) 2 3 4 60
  3. Aly and THO are required for assembly of the human TREX complex and association of TREX components with the spliced mRNA. (PMID: 23222130) Chi B … Cheng H (Nucleic acids research 2013) 3 4 60
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 45 60
  5. Nuclear localization of the pre-mRNA associating protein THOC7 depends upon its direct interaction with Fms tyrosine kinase interacting protein (FMIP). (PMID: 19059247) El Bounkari O … Tamura T (FEBS letters 2009) 3 4 60

Products for THOC7 Gene

  • Addgene plasmids for THOC7

Sources for THOC7 Gene

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