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THOC7 Gene

protein-coding   GIFtS: 53
GCID: GC03M063795

THO Complex 7 Homolog (Drosophila)

  Search for THOC7
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
THO Complex 7 Homolog (Drosophila)1 2     fSAP242 3
Functional Spliceosome-Associated Protein 241 2 3     hTREX302 3
NIF3L1BP12 3 5     NIF3L1-Binding Protein 12 3
Ngg1 Interacting Factor 3 Like 1 Binding Protein 11 2     THO Complex Subunit 7 Homolog2
Ngg1-Interacting Factor 3-Like Protein 1-Binding Protein 12 3     

External Ids:    HGNC: 298741   Entrez Gene: 801452   Ensembl: ENSG000001636347   OMIM: 6119655   UniProtKB: Q6I9Y23   

Export aliases for THOC7 gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for THOC7 Gene:
THOC7 (THO complex 7 homolog (Drosophila)) is a protein-coding gene. GO annotations related to this gene include RNA binding.

UniProtKB/Swiss-Prot: THOC7_HUMAN, Q6I9Y2
Function: Required for efficient export of polyadenylated RNA. Acts as component of the THO subcomplex of the TREX
complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically
associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a
transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited
in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export
to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essential for the export of Kaposi's
sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000003.12  NT_022517.19  NC_018914.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the THOC7 gene promoter:
         TBP   PPAR-gamma1   POU2F1a   TFIID   PPAR-gamma2   FOXL1   GATA-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTHOC7 promoter sequence
   Search Chromatin IP Primers for THOC7

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat THOC7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p14.1   Ensembl cytogenetic band:  3p14.1   HGNC cytogenetic band: 3p14.1

THOC7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
THOC7 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M063795:  view genomic region     (about GC identifiers)

Start:
63,819,546 bp from pter      End:
63,849,597 bp from pter
Size:
30,052 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: THOC7_HUMAN, Q6I9Y2 (See protein sequence)
Recommended Name: THO complex subunit 7 homolog  
Size: 204 amino acids; 23743 Da
Subunit: Component of the THO complex, which is composed of THOC1, THOC2, THOC3, THOC5, THOC6 and THOC7; together
with at least ALYREF/THOC4, DDX39B, SARNP/CIP29 and CHTOP, THO forms the transcription/export (TREX) complex
which seems to have a dynamic structure involving ATP-dependent remodeling. Interacts with NIF3L1 and THOC5
Secondary accessions: Q6P1L3 Q8WUF2 Q9H5H0

Explore the universe of human proteins at neXtProt for THOC7: NX_Q6I9Y2

Explore proteomics data for THOC7 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys32, Lys36
  • Modification sites at PhosphoSitePlus

  • See THOC7 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001272316.1  NP_001272333.1  NP_079351.2  

    ENSEMBL proteins: 
     ENSP00000295899   ENSP00000418518   ENSP00000419682   ENSP00000419443  

    THOC7 Human Recombinant Protein Products:

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    Novus Biologicals THOC7 Protein
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    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for THOC7 

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    Search eBioscience for ELISAs for THOC7 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    THOC: THO complex subunits

    1 InterPro protein domain:
     IPR008501 THOC7/Mft1

    Graphical View of Domain Structure for InterPro Entry Q6I9Y2

    ProtoNet protein and cluster: Q6I9Y2

    UniProtKB/Swiss-Prot: THOC7_HUMAN, Q6I9Y2
    Similarity: Belongs to the THOC7 family


    Find genes that share domains with THOC7           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: THOC7_HUMAN, Q6I9Y2
    Function: Required for efficient export of polyadenylated RNA. Acts as component of the THO subcomplex of the TREX
    complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically
    associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a
    transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited
    in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export
    to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essential for the export of Kaposi's
    sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003723RNA binding IEA--
    GO:0005515protein binding IPI19059247
         
    Find genes that share ontologies with THOC7           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for THOC7:
     Increased gamma-H2AX phosphory  Synthetic lethal with Ras 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for THOC7
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for THOC7
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    miRNA
    Products:
        
    miRTarBase miRNAs that target THOC7:
    hsa-mir-155-5p (MIRT020736), hsa-mir-26b-5p (MIRT029391)

    Block miRNA regulation of human, mouse, rat THOC7 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate THOC7
    SwitchGear 3'UTR luciferase reporter plasmidTHOC7 3' UTR sequence
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    Predesigned siRNA for gene silencing in human, mouse, rat THOC7

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    GenScript: all cDNA clones in your preferred vector: THOC7 (NM_025075)
    Browse Sino Biological Human cDNA Clones
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    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for THOC7


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    THOC7_HUMAN, Q6I9Y2: Cytoplasm. Nucleus. Nucleus speckle (Probable). Note=Interaction with THOC5 is required for
    nuclear localization
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol3

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000346transcription export complex IDA15833825
    GO:0000347THO complex IDA15998806
    GO:0000445THO complex part of transcription export complex IDA15998806
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--

    Find genes that share ontologies with THOC7           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for THOC7 About    
    See pathways by source

    SuperPathContained pathways About
    1RNA transport
    RNA transport


    Find genes that share SuperPaths with THOC7           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Kegg Pathway  (Kegg details for THOC7):
        RNA transport

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for THOC7
    Interactions:

        Search GeneGlobe Interaction Network for THOC7

    STRING Interaction Network Preview (showing 5 interactants - click image to see 18)

    Selected Interacting proteins for THOC7 (Q6I9Y21, 2, 3 ENSP000002958994) via UniProtKB, MINT, STRING, and/or I2D (see all 21)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    THOC5Q137691, 2, 3, ENSP000003809694EBI-716286,EBI-5280316 MINT-6800005 MINT-6799962 MINT-6800089 MINT-6799989 MINT-6800108 MINT-6800071 MINT-6799973 I2D: score=2 STRING: ENSP00000380969
    CHD3Q128732, 3MINT-64594 I2D: score=5 
    THOC1Q96FV92, ENSP000002616004MINT-6800089 MINT-6800071 STRING: ENSP00000261600
    GOT2P005052, 3, ENSP000002452064MINT-63341 I2D: score=5 STRING: ENSP00000245206
    MED8Q96G253, ENSP000002906634I2D: score=2 STRING: ENSP00000290663
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006397mRNA processing IEA--
    GO:0006406mRNA export from nucleus IDA17190602
    GO:0008380RNA splicing IEA--
    GO:0046784viral mRNA export from host cell nucleus IDA18974867

    Find genes that share ontologies with THOC7           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for THOC7



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for THOC7 gene (3 alternative transcripts): 
    NM_001285387.2  NM_001285404.1  NM_025075.3  

    Unigene Cluster for THOC7:

    THO complex 7 homolog (Drosophila)
    Hs.288151  [show with all ESTs]
    Unigene Representative Sequence: BF790283
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000295899(uc003dlt.4 uc003dlu.4) ENST00000469584 ENST00000473141
    ENST00000469153 ENST00000498422 ENST00000464327 ENST00000487570
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat THOC7 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate THOC7
    SwitchGear 3'UTR luciferase reporter plasmidTHOC7 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for THOC7
    Predesigned siRNA for gene silencing in human, mouse, rat THOC7
    Clone
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    GenScript: all cDNA clones in your preferred vector: THOC7 (NM_025075)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for THOC7
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat THOC7
    Primer
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    OriGene qPCR primer pairs and template standards for THOC7
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat THOC7
      QuantiTect SYBR Green Assays in human, mouse, rat THOC7
      QuantiFast Probe-based Assays in human, mouse, rat THOC7

    Additional mRNA sequence: 

    AK027098.1 AK225110.1 BC020599.2 BC065012.1 CR457373.1 

    6 DOTS entries:

    DT.447610  DT.95170210  DT.100774161  DT.100735002  DT.120885739  DT.120885691 

    Selected AceView cDNA sequences (see all 152):

    BI544790 BI758998 BF831844 AA865447 AW615194 BQ439261 AI298428 AW664600 
    H98650 CB121868 BU167343 BQ018944 AA782524 CA313791 AI242257 AA922295 
    CA844123 CB528375 AI740929 T93541 CB957768 BQ271092 BC020599 BM700193 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    THOC7 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACCATAATGT
    THOC7 Expression
    About this image


    THOC7 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Cerebral Cortex
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Ovary (Reproductive System)
             Oviduct
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Colon (Gastrointestinal Tract)
    THOC7 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    THOC7 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.288151
        Custom PCR Arrays for THOC7
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for THOC7

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for THOC7 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Thoc71 , 5 THO complex 7 homolog (Drosophila)1, 5 91.01(n)1
    97.55(a)1
      14 (7.08 cM)5
    662311  NM_025435.31  NP_079711.11 
     139490145 
    chicken
    (Gallus gallus)
    Aves THOC71 THO complex 7 homolog (Drosophila) 81.12(n)
    93.1(a)
      416077  NM_001098238.1  NP_001091708.1 
    lizard
    (Anolis carolinensis)
    Reptilia THOC76
    THO complex 7 homolog (Drosophila)
    83(a)
    1 ↔ 1
    GL343210.1(2021078-2041396)
    African clawed frog
    (Xenopus laevis)
    Amphibia nif3l1bp1-prov2 Ngg1 interacting factor 3 like 1 binding protein 1 79.77(n)    BC053810.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufa20e082 Transcribed sequence with moderate similarity to protein more 76.94(n)    CF550203.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta thoc71 thoc7 47.64(n)
    38.89(a)
      38033  NM_167804.2  NP_728489.2 
    worm
    (Caenorhabditis elegans)
    Secernentea B0513.26
    Protein B0513.2, isoform a
    23(a)
    1 ↔ 1
    IV(13882732-13884177) WBGene00007195


    ENSEMBL Gene Tree for THOC7 (if available)
    TreeFam Gene Tree for THOC7 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for THOC7 (see all 204)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs352560801,2
    C--63823014(+) TTATA-/TTTTTT 1 -- int10--------
    rs3717475721,2
    C--63823020(+) TTTTTT/-ATTTT 1 -- int11Minor allele frequency- -:0.00NA 2
    rs1416461691,2
    C--63834878(+) GCCAAC/TATGGT 1 -- int10--------
    rs728901111,2
    C,F--63834905(+) TAAAAG/ATACAA 1 -- int11Minor allele frequency- A:0.50WA 2
    rs1510861251,2
    --63835003(+) AGGTTA/GCAGCG 1 -- int10--------
    rs1411142171,2
    --63835020(+) GACTGC/TGTCAC 1 -- int10--------
    rs1149897171,2
    F--63835047(+) TGACAG/CAGTAA 1 -- int11Minor allele frequency- C:0.01NA 120
    rs1822783131,2
    --63835060(+) CACCAA/TCTCAA 1 -- int10--------
    rs1856222491,2
    --63835623(+) ATGTGC/TCACAT 1 -- int10--------
    rs1161426221,2
    C,F--63835733(+) GACCAT/CTGGAA 1 -- int11Minor allele frequency- C:0.02WA 118

    HapMap Linkage Disequilibrium report for THOC7 (63819546 - 63849597 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for THOC7:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv876886CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing THOC7
    DNA2.0 Custom Variant and Variant Library Synthesis for THOC7

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 611965    OMIM disorders: --


    Find genes that share disorders with THOC7           About GenesLikeMe

    Genetic Association Database (GAD): THOC7
    Human Genome Epidemiology (HuGE) Navigator: THOC7 (1 document)

    Export disorders for THOC7 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for THOC7 gene, integrated from 10 sources (see all 28):
    (articles sorted by number of sources associating them with THOC7)
        Utopia: connect your pdf to the dynamic
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    1. Identification and characterization of NIF3L1 BP1, a novel cytoplasmic interaction partner of the NIF3L1 protein. (PubMed id 12951069)1, 2, 3 Tascou S.... Burfeind P. (Biochem. Biophys. Res. Commun. 2003)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    3. Nuclear localization of the pre-mRNA associating protein THOC7 depends upon its direct interaction with Fms tyrosine kinase interacting protein (FMIP). (PubMed id 19059247)1, 2 El Bounkari O.... Tamura T. (FEBS Lett. 2009)
    4. Recruitment of the complete hTREX complex is required for Kaposi's sarcoma-associated herpesvirus intronless mRNA nuclear export and virus replication. (PubMed id 18974867)1, 2 Boyne J.R.... Whitehouse A. (PLoS Pathog. 2008)
    5. Human mRNA export machinery recruited to the 5' end of mRNA. (PubMed id 17190602)1, 2 Cheng H.... Reed R. (Cell 2006)
    6. Recruitment of the human TREX complex to mRNA during splicing. (PubMed id 15998806)1, 2 Masuda S.... Reed R. (Genes Dev. 2005)
    7. Linking transcriptional elongation and messenger RNA export to metastatic breast cancers. (PubMed id 15833825)1, 2 Guo S.... Shiekhattar R. (Cancer Res. 2005)
    8. Aly and THO are required for assembly of the human TREX complex and association of TREX components with the spliced mRNA. (PubMed id 23222130)2 Chi B....Cheng H. (Nucleic Acids Res. 2013)
    9. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    10. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 80145 HGNC: 29874 AceView: NIF3L1BP1 Ensembl:ENSG00000163634 euGenes: HUgn80145
    ECgene: THOC7 Kegg: 80145 H-InvDB: THOC7

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for THOC7 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for THOC7 gene:
    Search GeneIP for patents involving THOC7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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