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Aliases for THOC6 Gene

Aliases for THOC6 Gene

  • THO Complex 6 2 3
  • Functional Spliceosome-Associated Protein 35 2 3 4
  • FSAP35 3 4 6
  • WD Repeat-Containing Protein 58 3 4
  • WD Repeat Domain 58 2 3
  • WDR58 3 4
  • BBIS 3 6
  • THO Complex 6 Homolog (Drosophila) 2
  • THO Complex Subunit 6 Homolog 3
  • THO Complex 6 Homolog 3

External Ids for THOC6 Gene

Previous Symbols for THOC6 Gene

  • WDR58

Summaries for THOC6 Gene

GeneCards Summary for THOC6 Gene

THOC6 (THO Complex 6) is a Protein Coding gene. Diseases associated with THOC6 include beaulieu-boycott-innes syndrome and developmental delay-microcephaly-facial dysmorphism syndrome, hutterite type. Among its related pathways are RNA transport. GO annotations related to this gene include RNA binding.

UniProtKB/Swiss-Prot for THOC6 Gene

  • Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5 end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essential for the export of Kaposis sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. Plays a role in apoptosis negative control involved in brain development.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for THOC6 Gene

Genomics for THOC6 Gene

Genomic Location for THOC6 Gene

Start:
3,024,027 bp from pter
End:
3,027,755 bp from pter
Size:
3,729 bases
Orientation:
Plus strand

Genomic View for THOC6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for THOC6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for THOC6 Gene

Regulatory Elements for THOC6 Gene

Proteins for THOC6 Gene

  • Protein details for THOC6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86W42-THOC6_HUMAN
    Recommended name:
    THO complex subunit 6 homolog
    Protein Accession:
    Q86W42
    Secondary Accessions:
    • B2RA85
    • Q8NBR1
    • Q9BTV9

    Protein attributes for THOC6 Gene

    Size:
    341 amino acids
    Molecular mass:
    37535 Da
    Quaternary structure:
    • Component of the THO complex, which is composed of THOC1, THOC2, THOC3, THOC5, THOC6 and THOC7; together with at least ALYREF/THOC4, DDX39B, SARNP/CIP29 and CHTOP, THO forms the transcription/export (TREX) complex which seems to have a dynamic structure involving ATP-dependent remodeling.
    SequenceCaution:
    • Sequence=BAG36782.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for THOC6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for THOC6 Gene

Proteomics data for THOC6 Gene at MOPED

Post-translational modifications for THOC6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for THOC6 Gene

No data available for DME Specific Peptides for THOC6 Gene

Domains for THOC6 Gene

Gene Families for THOC6 Gene

HGNC:
  • WDR :WD repeat domain containing
  • THOC :THO complex subunits

Protein Domains for THOC6 Gene

UniProtKB/Swiss-Prot:

THOC6_HUMAN
Family:
  • Belongs to the WD repeat THOC6 family.:
    • Q86W42
Similarity:
  • Contains 7 WD repeats.:
    • Q86W42
genes like me logo Genes that share domains with THOC6: view

Function for THOC6 Gene

Molecular function for THOC6 Gene

UniProtKB/Swiss-Prot Function: Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5 end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essential for the export of Kaposis sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. Plays a role in apoptosis negative control involved in brain development.

Gene Ontology (GO) - Molecular Function for THOC6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IEA --
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with THOC6: view

Phenotypes for THOC6 Gene

GenomeRNAi human phenotypes for THOC6:
genes like me logo Genes that share phenotypes with THOC6: view

miRNA for THOC6 Gene

miRTarBase miRNAs that target THOC6

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for THOC6 Gene

Localization for THOC6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for THOC6 Gene

Nucleus. Nucleus speckle.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for THOC6 Gene COMPARTMENTS Subcellular localization image for THOC6 gene
Compartment Confidence
nucleus 5
cytosol 2
extracellular 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for THOC6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000346 transcription export complex IDA 15833825
GO:0000347 THO complex IDA 15998806
GO:0000445 THO complex part of transcription export complex IDA 15998806
GO:0005634 nucleus IDA 23621916
GO:0005654 nucleoplasm IDA --
genes like me logo Genes that share ontologies with THOC6: view

Pathways for THOC6 Gene

SuperPathways for THOC6 Gene

Superpath Contained pathways
1 RNA transport
genes like me logo Genes that share pathways with THOC6: view

Pathways by source for THOC6 Gene

1 KEGG pathway for THOC6 Gene

Gene Ontology (GO) - Biological Process for THOC6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006397 mRNA processing IEA --
GO:0006406 mRNA export from nucleus IDA 17190602
GO:0006915 apoptotic process IEA --
GO:0007417 central nervous system development IMP 23621916
GO:0008380 RNA splicing IEA --
genes like me logo Genes that share ontologies with THOC6: view

Transcripts for THOC6 Gene

Unigene Clusters for THOC6 Gene

THO complex 6 homolog (Drosophila):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for THOC6 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11
SP1:
SP2:
SP3:

Relevant External Links for THOC6 Gene

GeneLoc Exon Structure for
THOC6
ECgene alternative splicing isoforms for
THOC6

Expression for THOC6 Gene

mRNA expression in normal human tissues for THOC6 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for THOC6 Gene

SOURCE GeneReport for Unigene cluster for THOC6 Gene Hs.412304

genes like me logo Genes that share expressions with THOC6: view

Orthologs for THOC6 Gene

This gene was present in the common ancestor of animals.

Orthologs for THOC6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia THOC6 36
  • 99.61 (n)
  • 99.71 (a)
THOC6 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia THOC6 36
  • 90.42 (n)
  • 95.6 (a)
THOC6 37
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia THOC6 36
  • 89.64 (n)
  • 97.36 (a)
THOC6 37
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Thoc6 36
  • 86.8 (n)
  • 95.31 (a)
Thoc6 16
Thoc6 37
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia THOC6 37
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia THOC6 37
  • 78 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Thoc6 36
  • 87.39 (n)
  • 95.89 (a)
lizard
(Anolis carolinensis)
Reptilia THOC6 37
  • 64 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100498236 36
  • 63.72 (n)
  • 62.2 (a)
Str.14482 36
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.7460 36
zebrafish
(Danio rerio)
Actinopterygii thoc6 36
  • 61.46 (n)
  • 59.69 (a)
thoc6 37
  • 59 (a)
OneToOne
wufb96g04 36
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005429 36
  • 48.59 (n)
  • 36.36 (a)
fruit fly
(Drosophila melanogaster)
Insecta thoc6 36
  • 42.93 (n)
  • 30.42 (a)
thoc6 37
  • 25 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.830 37
  • 35 (a)
OneToOne
Species with no ortholog for THOC6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for THOC6 Gene

ENSEMBL:
Gene Tree for THOC6 (if available)
TreeFam:
Gene Tree for THOC6 (if available)

Paralogs for THOC6 Gene

No data available for Paralogs for THOC6 Gene

Variants for THOC6 Gene

Sequence variations from dbSNP and Humsavar for THOC6 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs960274 -- 3,026,662(-) GGGGC(A/G)ATGTC intron-variant
rs8057262 -- 3,026,392(+) ATCAA(C/T)GCTTT reference, synonymous-codon
rs34472080 -- 3,026,368(-) AGGCT(A/G)GTCCT reference, synonymous-codon
rs35581133 -- 3,026,429(+) ATGTG(-/C)ACTGT intron-variant
rs116675970 -- 3,027,029(+) CCCAC(A/C)ATGGG reference, missense

Structural Variations from Database of Genomic Variants (DGV) for THOC6 Gene

Variant ID Type Subtype PubMed ID
nsv905162 CNV Gain 21882294
nsv905170 CNV Loss 21882294
dgv2575n71 CNV Loss 21882294
dgv2576n71 CNV Loss 21882294
nsv509588 CNV Insertion 20534489
nsv510673 CNV Loss 20534489
nsv905185 CNV Loss 21882294
dgv2577n71 CNV Loss 21882294
dgv2578n71 CNV Loss 21882294
nsv905193 CNV Loss 21882294
dgv2579n71 CNV Loss 21882294
nsv905197 CNV Loss 21882294
nsv833125 CNV Loss 17160897

Relevant External Links for THOC6 Gene

HapMap Linkage Disequilibrium report
THOC6
Human Gene Mutation Database (HGMD)
THOC6

Disorders for THOC6 Gene

(1) OMIM Diseases for THOC6 Gene (615403)

UniProtKB/Swiss-Prot

THOC6_HUMAN
  • Beaulieu-Boycott-Innes syndrome (BBIS) [MIM:613680]: An autosomal recessive neurodevelopmental disorder characterized by delayed development, moderate intellectual disability, and dysmorphic facial features. Other developmental anomalies, such as cardiac and renal defects, may also occur. {ECO:0000269 PubMed:23621916}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for THOC6

Genetic Association Database (GAD)
THOC6
Human Genome Epidemiology (HuGE) Navigator
THOC6
genes like me logo Genes that share disorders with THOC6: view

Publications for THOC6 Gene

  1. Recruitment of the human TREX complex to mRNA during splicing. (PMID: 15998806) Masuda S. … Reed R. (Genes Dev. 2005) 2 3 4
  2. Human mRNA export machinery recruited to the 5' end of mRNA. (PMID: 17190602) Cheng H. … Reed R. (Cell 2006) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Linking transcriptional elongation and messenger RNA export to metastatic breast cancers. (PMID: 15833825) Guo S. … Shiekhattar R. (Cancer Res. 2005) 3 4
  5. Recruitment of the complete hTREX complex is required for Kaposi's sarcoma-associated herpesvirus intronless mRNA nuclear export and virus replication. (PMID: 18974867) Boyne J.R. … Whitehouse A. (PLoS Pathog. 2008) 3 4

Products for THOC6 Gene

Sources for THOC6 Gene

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