Aliases for THOC6 Gene
External Ids for THOC6 Gene
Previous HGNC Symbols for THOC6 Gene
Previous GeneCards Identifiers for THOC6 Gene
GeneCards Summary for THOC6 Gene
THOC6 (THO Complex 6) is a Protein Coding gene. Diseases associated with THOC6 include beaulieu-boycott-innes syndrome and developmental delay-microcephaly-facial dysmorphism syndrome, hutterite type. Among its related pathways are RNA transport. GO annotations related to this gene include RNA binding.
UniProtKB/Swiss-Prot for THOC6 Gene
Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5 end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essential for the export of Kaposis sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. Plays a role in apoptosis negative control involved in brain development.