Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

THOC6 Gene

protein-coding   GIFtS: 53
GCID: GC16P003128

THO Complex 6 Homolog (Drosophila)

(Previous name: WD repeat domain 58)
(Previous symbol: WDR58)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
THO Complex 6 Homolog (Drosophila)1 2     fSAP352 3
WDR581 2 3     WD Repeat-Containing Protein 582 3
Functional Spliceosome-Associated Protein 351 2 3     BBIS2
WD Repeat Domain 581 2     THO Complex Subunit 6 Homolog2

External Ids:    HGNC: 283691   Entrez Gene: 792282   Ensembl: ENSG000001316527   OMIM: 6154035   UniProtKB: Q86W423   

Export aliases for THOC6 gene to outside databases

Previous GC identifers: GC16P003017 GC16P003079 GC16P003045 GC16P003080 GC16P003081 GC16P003113


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for THOC6 Gene: 
THOC6 (THO complex 6 homolog (Drosophila)) is a protein-coding gene. Diseases associated with THOC6 include kaposi's sarcoma, and sarcoma. GO annotations related to this gene include RNA binding.

UniProtKB/Swiss-Prot: THOC6_HUMAN, Q86W42
Function: Component of the THO subcomplex of the TREX complex. The TREX complex specifically associates with
spliced mRNA and not with unspliced pre-mRNA. It is recruited to spliced mRNAs by a transcription-independent
mechanism. Binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and
cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export. The recruitment
occurs via an interaction between ALYREF/THOC4 and the cap-binding protein NCBP1. DDX39B functions as a bridge
between ALYREF/THOC4 and the THO complex. The TREX complex is essential for the export of Kaposi's
sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. The recruitment of the
TREX complex to the intronless viral mRNA occurs via an interaction between KSHV ORF57 protein and ALYREF/THOC4




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NT_010393.16  NC_018927.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the THOC6 gene promoter:
         COUP-TF1   COUP-TF   AP-1   ATF-2   COUP   HNF-4alpha2   c-Jun   HNF-4alpha1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTHOC6 promoter sequence
   Search SABiosciences Chromatin IP Primers for THOC6

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat THOC6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p13.3   Ensembl cytogenetic band:  16p13.3   HGNC cytogenetic band: 16p13.3

THOC6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
THOC6 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P003128:  view genomic region     (about GC identifiers)

Start:
3,074,028 bp from pter      End:
3,077,756 bp from pter
Size:
3,729 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: THOC6_HUMAN, Q86W42 (See protein sequence)
Recommended Name: THO complex subunit 6 homolog  
Size: 341 amino acids; 37535 Da
Subunit: Component of the THO complex, which is composed of THOC1, THOC2, THOC5, THOC6 and THOC7. Together with
THOC3, ALYREF/THOC4 and DDX39B, THO forms the transcription/export (TREX) complex
Sequence caution: Sequence=BAG36782.1; Type=Erroneous initiation;
Secondary accessions: B2RA85 Q8NBR1 Q9BTV9
Alternative splicing: 3 isoforms:  Q86W42-1   Q86W42-2   Q86W42-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for THOC6: NX_Q86W42

Explore proteomics data for THOC6 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q86W42

  • THOC6 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    THOC6 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001135822.1  NP_077315.2  

    ENSEMBL proteins: 
     ENSP00000326531   ENSP00000458295   ENSP00000460015   ENSP00000253952  

    Human Recombinant Protein Products for THOC6: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for THOC6
    OriGene Protein Over-expression Lysate for THOC6
    OriGene MassSpec for THOC6 
    OriGene Custom Protein Services for THOC6
    GenScript Custom Purified and Recombinant Proteins Services for THOC6
    Novus Biologicals THOC6 Proteins
    Novus Biologicals THOC6 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for THOC6 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000346transcription export complex IDA15833825
    GO:0000347THO complex IDA15998806
    GO:0000445THO complex part of transcription export complex IDA15998806
    GO:0005634nucleus IDA--

    THOC6 for ontologies           About GeneDecksing



    THOC6 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for THOC6
    GenScript Custom Superior Antibodies Services for THOC6
    Novus Biologicals THOC6 Antibodies
    Abcam antibodies for THOC6
    Cloud-Clone Corp. Antibodies for THOC6 
    Search ThermoFisher Antibodies for THOC6
    LSBio Antibodies in human, mouse, rat for THOC6 

    Assay Products for THOC6: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for THOC6
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for THOC6
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for THOC6 
    Cloud-Clone Corp. CLIAs for THOC6


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    WDR: WD repeat domain containing
    THOC: THO complex subunits

    4 InterPro protein domains:
     IPR019775 WD40_repeat_CS
     IPR001680 WD40_repeat
     IPR017986 WD40_repeat_dom
     IPR015943 WD40/YVTN_repeat-like_dom

    Graphical View of Domain Structure for InterPro Entry Q86W42

    ProtoNet protein and cluster: Q86W42

    UniProtKB/Swiss-Prot: THOC6_HUMAN, Q86W42
    Similarity: Belongs to the WD repeat THOC6 family
    Similarity: Contains 7 WD repeats


    THOC6 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: THOC6_HUMAN, Q86W42
    Function: Component of the THO subcomplex of the TREX complex. The TREX complex specifically associates with
    spliced mRNA and not with unspliced pre-mRNA. It is recruited to spliced mRNAs by a transcription-independent
    mechanism. Binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and
    cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export. The recruitment
    occurs via an interaction between ALYREF/THOC4 and the cap-binding protein NCBP1. DDX39B functions as a bridge
    between ALYREF/THOC4 and the THO complex. The TREX complex is essential for the export of Kaposi's
    sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. The recruitment of the
    TREX complex to the intronless viral mRNA occurs via an interaction between KSHV ORF57 protein and ALYREF/THOC4

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003723RNA binding IEA--
    GO:0005515protein binding ----
         
    THOC6 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for THOC6:
     Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for THOC6 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for THOC6

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for THOC6 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for THOC6 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat THOC6
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate THOC6
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for THOC6
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat THOC6

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for THOC6
    Sirion Biotech Customized adenovirus for overexpression of THOC6

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for THOC6 (see all 13)
    OriGene ORF clones in mouse, rat for THOC6
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): THOC6 (NM_024339)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for THOC6
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat THOC6
    Sirion Biotech Customized lentivirus for stable overexpression of THOC6 
                         Customized lentivirus expression plasmids for stable overexpression of THOC6 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for THOC6
    Search LifeMap BioReagents cell lines for THOC6
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for THOC6


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for THOC6 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1RNA transport
    RNA transport

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1         Kegg Pathway  (Kegg details for THOC6):
        RNA transport


    THOC6 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for THOC6

    STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

    5/16 Interacting proteins for THOC6 (Q86W422, 3 ENSP000003265314) via UniProtKB, MINT, STRING, and/or I2D (see all 16)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    THOC5Q137692, ENSP000003809694MINT-7040334 MINT-7040353 MINT-7040368 STRING: ENSP00000380969
    THOC1Q96FV92, ENSP000002616004MINT-7040334 MINT-7040353 MINT-7040368 STRING: ENSP00000261600
    THOC2Q8NI272, ENSP000002458384MINT-7040353 MINT-7040368 STRING: ENSP00000245838
    ESR2Q927313, ENSP000003439254I2D: score=1 STRING: ENSP00000343925
    RNF2Q994963I2D: score=2 
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006397mRNA processing IEA--
    GO:0006406mRNA export from nucleus IDA17190602
    GO:0006915apoptotic process IEA--
    GO:0007417central nervous system development IMP--
    GO:0008380RNA splicing IEA--

    THOC6 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for THOC6

    Search CenterWatch for drugs/clinical trials and news about THOC6

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for THOC6 gene (2 alternative transcripts): 
    NM_001142350.1  NM_024339.3  

    Unigene Cluster for THOC6:

    THO complex 6 homolog (Drosophila)
    Hs.412304  [show with all ESTs]
    Unigene Representative Sequence: BQ057555
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000576143 ENST00000574957 ENST00000326266(uc002ctb.2 uc002ctd.2)
    ENST00000574549(uc002cta.2) ENST00000571057 ENST00000575576 ENST00000574498
    ENST00000573704 ENST00000253952 ENST00000571046
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat THOC6
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate THOC6
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for THOC6
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat THOC6
    Clone
    Products:
         
    OriGene clones in human, mouse for THOC6 (see all 13)
    OriGene ORF clones in mouse, rat for THOC6
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): THOC6 (NM_024339)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for THOC6
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat THOC6
    Sirion Biotech Customized lentivirus for stable overexpression of THOC6 
                         Customized lentivirus expression plasmids for stable overexpression of THOC6 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for THOC6
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat THOC6
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat THOC6
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat THOC6

    Additional mRNA sequence: 

    AK075330.1 AK308960.1 AK310113.1 AK314086.1 AL832548.1 BC003118.1 BC050674.1 

    14 DOTS entries:

    DT.408652  DT.92434369  DT.408651  DT.92434372  DT.100787603  DT.95289379  DT.100801859  DT.95084812 
    DT.120679707  DT.420514  DT.95079278  DT.100806086  DT.75103280  DT.92411825 

    24/168 AceView cDNA sequences (see all 168):

    BM477797 CR624641 BI910103 BQ233339 CR619161 BE407790 CA489681 AA404589 
    BE732048 BQ687640 BU855953 BG025874 BI907266 BF127516 BG759679 AL832548 
    BM693592 BM457458 BQ056498 BC050674 NM_024339 BQ056713 BX457909 BE378601 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for THOC6    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11
    SP1:                                                                        
    SP2:                                                                        
    SP3:                                                                        


    ECgene alternative splicing isoforms for THOC6

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    THOC6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTTTCCACCG
    THOC6 Expression
    About this image


    See THOC6 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for THOC6

    SOURCE GeneReport for Unigene cluster: Hs.412304
        SABiosciences Custom PCR Arrays for THOC6
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for THOC6
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat THOC6
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat THOC6
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat THOC6
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for THOC6

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for THOC6 gene from 7/16 species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Thoc61 , 5 THO complex 6 homolog (Drosophila)1, 5 86.8(n)1
    95.31(a)1
      17 (11.97 cM)5
    3866121  NM_001008425.11  NP_001008425.11 
     236686145 
    lizard
    (Anolis carolinensis)
    Reptilia THOC66
    THO complex 6 homolog (Drosophila)
    65(a)
    1 ↔ 1
    GL343516.1(478923-488835)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.144822 Transcribed sequence with weak similarity to protein more 71.5(n)    137728044 
    zebrafish
    (Danio rerio)
    Actinopterygii wufb96g042 Transcribed sequence with weak similarity to protein more 77.54(n)    BM317325.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta thoc61 CG5632-PA 43.4(n)
    29.87(a)
      39394  NM_140300.3  NP_648557.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons DWA11 THO complex subunit 6 43.7(n)
    34.98(a)
      816462  NM_179658.3  NP_849989.1 
    rice
    (Oryza sativa)
    Liliopsida Os09g03636001 hypothetical protein 47.22(n)
    38.02(a)
      4346861  NM_001069528.1  NP_001062993.1 


    ENSEMBL Gene Tree for THOC6 (if available)
    TreeFam Gene Tree for THOC6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/69 SNPs in THOC6 are shown (see all 69)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1174696831,2
    C,F--3076331(+) TGAAGC/TCACTT 2 -- int12Minor allele frequency- T:0.01NA EU 1431
    rs344720801,2
    C,F--3076369(-) AGGCTG/AGTCCT 4 /T syn12Minor allele frequency- A:0.00NA EU 1395
    rs80572621,2
    C,F,H--3076393(+) ATCAAC/TGCTTT 4 N syn1 ese313Minor allele frequency- T:0.05NS NA WA CSA EU 7301
    rs2013934671,2
    C--3076405(+) CTGCTG/AGTCCC 4 /L syn11Minor allele frequency- A:0.00EU 1323
    rs1418622661,2
    C--3076485(+) TGACAC/TTGACT 2 -- int10--------
    rs1387060381,2
    C,F--3076587(+) TTTCAC/TGGTGA 4 T M mis11Minor allele frequency- T:0.00NA 4548
    rs9602741,2
    C,F,H--3076663(-) GGGGCG/AATGTC 2 -- int120Minor allele frequency- A:0.15MN EA NS NA EU 4449
    rs1493842721,2
    C,F--3076690(+) CCTCCG/AGGGCC 4 /Q /R mis11Minor allele frequency- A:0.00NA 4494
    rs2018795401,2
    C--3076710(+) ACATCC/G/TACTGC 6 H D Y mis11EU 1111
    rs1997953811,2
    C--3076765(+) GGATGA/GAGCTG 4 E G mis10--------

    HapMap Linkage Disequilibrium report for THOC6 (3074028 - 3077756 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/13 variations for THOC6 (see all 13):    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv509588CNV Insertion20534489
    dgv2579n71CNV Loss21882294
    nsv510673CNV Loss20534489
    nsv905193CNV Loss21882294
    nsv905170CNV Loss21882294
    nsv905185CNV Loss21882294
    nsv905197CNV Loss21882294
    dgv2575n71CNV Loss21882294
    nsv833125CNV Loss17160897
    dgv2576n71CNV Loss21882294


    Human Gene Mutation Database (HGMD): THOC6
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing THOC6
    DNA2.0 Custom Variant and Variant Library Synthesis for THOC6

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 615403    OMIM disorders: --

    3 diseases for THOC6:    About MalaCards
    kaposi's sarcoma    sarcoma    breast cancer


    THOC6 for disorders           About GeneDecksing

    Genetic Association Database (GAD): THOC6
    Human Genome Epidemiology (HuGE) Navigator: THOC6 (4 documents)

    Export disorders for THOC6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for THOC6 gene, integrated from 9 sources (see all 20):
    (articles sorted by number of sources associating them with THOC6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    2. Association between genetic variants in VEGF, ERCC3 a nd occupational benzene haematotoxicity. (PubMed id 19773279)1, 4 Hosgood H.D....Lan Q. (2009)
    3. Recruitment of the complete hTREX complex is required for Kaposi's sarcoma-associated herpesvirus intronless mRNA nuclear export and virus replication. (PubMed id 18974867)1, 2 Boyne J.R.... Whitehouse A. (2008)
    4. Human mRNA export machinery recruited to the 5' end of mRNA. (PubMed id 17190602)1, 2 Cheng H.... Reed R. (2006)
    5. Recruitment of the human TREX complex to mRNA during splicing. (PubMed id 15998806)1, 2 Masuda S.... Reed R. (2005)
    6. Linking transcriptional elongation and messenger RNA export to metastatic breast cancers. (PubMed id 15833825)1, 2 Guo S.... Shiekhattar R. (2005)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
    9. Interlaboratory reproducibility of large-scale human p rotein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (2013)
    10. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 79228 HGNC: 28369 AceView: MGC2655 Ensembl:ENSG00000131652 euGenes: HUgn79228
    ECgene: THOC6 Kegg: 79228 H-InvDB: THOC6

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for THOC6 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for THOC6 gene:
    Search GeneIP for patents involving THOC6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for THOC6  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for THOC6  
     OriGene MassSpec something-or-other for THOC6   OriGene clones in human, mouse for THOC6  
     OriGene qSTAR qPCR primer pairs in human, mouse for THOC6   OriGene Purified Protein for THOC6  
     OriGene ORF clones in mouse, rat for THOC6   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for THOC6   OriGene Custom Protein Services for THOC6  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat THOC6
     QIAGEN SeqTarget long-range PCR primers for resequencing THOC6
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat THOC6
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat THOC6
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat THOC6
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat THOC6
     GenScript Custom Purified and Recombinant Proteins Services for THOC6 GenScript cDNA clones with any tag delivered in your preferred vector for THOC6
     GenScript Custom Assay Services for THOC6 GenScript Custom Superior Antibodies Services for THOC6
     GenScript Custom overexpressing Cell Line Services for THOC6 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in THOC6 promoter
     Search Chromatin IP Primers for THOC6
     RT2 qPCR Primer Assay in human, mouse, rat THOC6
     Search GNC Networks for THOC6
     SABiosciences Custom PCR Arrays for THOC6
     Search Tocris compounds for THOC6
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     THOC6 antibodies
     THOC6 proteins
     THOC6 lysates
     Antibodies for THOC6
     See all of Abcam's Antibodies, Kits and Proteins for THOC6
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for THOC6
     Antibodies for THOC6
     ELISAs for THOC6
     CLIAs for THOC6
     Search LifeMap BioReagents cell lines for THOC6
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for THOC6
     Browse SwitchGear 3'UTR luciferase reporter plasmids for THOC6
     SwitchGear Promoter luciferase reporter plasmids for THOC6
     Search ThermoFisher Antibodies for THOC6
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat THOC6
     inGenious Targeting Laboratory - Custom generated mouse model solutions for THOC6
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for THOC6
    Customized:
     lentivirus for stable overexpression of THOC6
     lentivirus expression plasmids for stable overexpression of THOC6
     adenovirus for overexpression of THOC6
     LSBio Antibodies in human, mouse, rat for THOC6
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      THOC6 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4