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Aliases for THOC5 Gene

Aliases for THOC5 Gene

  • THO Complex 5 2 3 5
  • Functional Spliceosome-Associated Protein 79 2 3 4
  • NF2/Meningioma Region Protein PK1.3 3 4
  • Placental Protein 39.2 3 4
  • C22orf19 3 4
  • HTREX90 3 4
  • PP39.2 3 4
  • FSAP79 3 4
  • Chromosome 22 Open Reading Frame 19 2
  • Fms-Interacting Protein 3
  • KIAA0983 4
  • PK1.3 3
  • Fmip 3

External Ids for THOC5 Gene

Previous HGNC Symbols for THOC5 Gene

  • C22orf19

Previous GeneCards Identifiers for THOC5 Gene

  • GC00U902870
  • GC22M028231
  • GC22M029901
  • GC22M012867

Summaries for THOC5 Gene

GeneCards Summary for THOC5 Gene

THOC5 (THO Complex 5) is a Protein Coding gene. Diseases associated with THOC5 include neurofibromatosis, type 2. Among its related pathways are Gene Expression and RNA transport. GO annotations related to this gene include mRNA binding.

UniProtKB/Swiss-Prot for THOC5 Gene

  • Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5 end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essential for the export of Kaposis sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. THOC5 in conjunction with ALYREF/THOC4 functions in NXF1-NXT1 mediated nuclear export of HSP70 mRNA; both proteins enhance the RNA binding activity of NXF1 and are required for NXF1 localization to the nuclear rim. Involved in transcription elongation and genome stability. Involved in alternative polyadenylation site choice by recruiting CPSF6 to 5 region of target genes; probably mediates association of the TREX and CFIm complexes.

  • Regulates the expression of myeloid transcription factors CEBPA, CEBPB and GAB2 by enhancing the levels of phosphatidylinositol 3,4,5-trisphosphate. May be involved in the differentiation of granulocytes and adipocytes. Essential for hematopoietic primitive cell survival and plays an integral role in monocytic development.

Gene Wiki entry for THOC5 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for THOC5 Gene

Genomics for THOC5 Gene

Regulatory Elements for THOC5 Gene

Promoters for THOC5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around THOC5 on UCSC Golden Path with GeneCards custom track

Genomic Location for THOC5 Gene

Chromosome:
22
Start:
29,505,879 bp from pter
End:
29,555,216 bp from pter
Size:
49,338 bases
Orientation:
Minus strand

Genomic View for THOC5 Gene

Genes around THOC5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
THOC5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for THOC5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for THOC5 Gene

Proteins for THOC5 Gene

  • Protein details for THOC5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13769-THOC5_HUMAN
    Recommended name:
    THO complex subunit 5 homolog
    Protein Accession:
    Q13769
    Secondary Accessions:
    • O60839
    • Q9UPZ5

    Protein attributes for THOC5 Gene

    Size:
    683 amino acids
    Molecular mass:
    78508 Da
    Quaternary structure:
    • Interacts with phosphorylated CSF1R (By similarity). Component of the THO complex, which is composed of THOC1, THOC2, THOC3, THOC5, THOC6 and THOC7; together with at least ALYREF/THOC4, DDX39B, SARNP/CIP29 and CHTOP, THO forms the transcription/export (TREX) complex which seems to have a dynamic structure involving ATP-dependent remodeling. Interacts with ALYREF/THOC4, and THOC7. Interacts (via N-terminus) with the NTF2 domain of NXF1. Forms a complex with CEBPB. Interacts with CPSF6; indicative for an association with the cleavage factor Im (CFIm) complex. Interacts with THOC1 (By similarity). Interacts with LUZP4. Interacts with NCBP3 (PubMed:26382858).
    SequenceCaution:
    • Sequence=BAA76827.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for THOC5 Gene

Proteomics data for THOC5 Gene at MOPED

Post-translational modifications for THOC5 Gene

  • Phosphorylated on tyrosine upon binding to activated CSF1R; which causes a dissociation of the two proteins. Phosphorylation on Ser-5 and/or Ser-6 is required for nuclear export. Phosphorylated on Thr-328 in insulin-stimulated adipocytes (By similarity). Phosphorylation at Tyr-225 modulates mRNA binding.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

No data available for DME Specific Peptides for THOC5 Gene

Domains & Families for THOC5 Gene

Gene Families for THOC5 Gene

Protein Domains for THOC5 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for THOC5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q13769

UniProtKB/Swiss-Prot:

THOC5_HUMAN :
  • Belongs to the THOC5 family.
Family:
  • Belongs to the THOC5 family.
genes like me logo Genes that share domains with THOC5: view

Function for THOC5 Gene

Molecular function for THOC5 Gene

UniProtKB/Swiss-Prot Function:
Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5 end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essential for the export of Kaposis sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. THOC5 in conjunction with ALYREF/THOC4 functions in NXF1-NXT1 mediated nuclear export of HSP70 mRNA; both proteins enhance the RNA binding activity of NXF1 and are required for NXF1 localization to the nuclear rim. Involved in transcription elongation and genome stability. Involved in alternative polyadenylation site choice by recruiting CPSF6 to 5 region of target genes; probably mediates association of the TREX and CFIm complexes.
UniProtKB/Swiss-Prot Function:
Regulates the expression of myeloid transcription factors CEBPA, CEBPB and GAB2 by enhancing the levels of phosphatidylinositol 3,4,5-trisphosphate. May be involved in the differentiation of granulocytes and adipocytes. Essential for hematopoietic primitive cell survival and plays an integral role in monocytic development.
genes like me logo Genes that share phenotypes with THOC5: view

Animal Models for THOC5 Gene

MGI Knock Outs for THOC5:

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for THOC5 Gene

Localization for THOC5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for THOC5 Gene

Nucleus. Cytoplasm. Note=Shuttles between nucleus and cytoplasm. {ECO:0000269 PubMed:19059247}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for THOC5 Gene COMPARTMENTS Subcellular localization image for THOC5 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for THOC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000347 THO complex IDA 15998806
GO:0005634 nucleus IDA 19059247
GO:0005654 nucleoplasm IDA,TAS --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with THOC5: view

Pathways & Interactions for THOC5 Gene

genes like me logo Genes that share pathways with THOC5: view

SIGNOR curated interactions for THOC5 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for THOC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006406 mRNA export from nucleus IDA,TAS --
GO:0032786 positive regulation of DNA-templated transcription, elongation IMP 22144908
GO:0046784 viral mRNA export from host cell nucleus IDA 18974867
GO:0060215 primitive hemopoiesis ISS --
genes like me logo Genes that share ontologies with THOC5: view

Drugs & Compounds for THOC5 Gene

No Compound Related Data Available

Transcripts for THOC5 Gene

Unigene Clusters for THOC5 Gene

THO complex 5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for THOC5 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24a ·
SP1: - -
SP2: - - - - -
SP3: - -
SP4: -
SP5:

ExUns: 24b
SP1:
SP2:
SP3:
SP4:
SP5:

Relevant External Links for THOC5 Gene

GeneLoc Exon Structure for
THOC5
ECgene alternative splicing isoforms for
THOC5

Expression for THOC5 Gene

mRNA expression in normal human tissues for THOC5 Gene

mRNA differential expression in normal tissues according to GTEx for THOC5 Gene

This gene is overexpressed in Whole Blood (x4.7).

Protein differential expression in normal tissues from HIPED for THOC5 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (21.1) and Lymph node (7.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for THOC5 Gene



SOURCE GeneReport for Unigene cluster for THOC5 Gene Hs.75361

mRNA Expression by UniProt/SwissProt for THOC5 Gene

Q13769-THOC5_HUMAN
Tissue specificity: Ubiquitously expressed.
genes like me logo Genes that share expression patterns with THOC5: view

Protein tissue co-expression partners for THOC5 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for THOC5 Gene

Orthologs for THOC5 Gene

This gene was present in the common ancestor of animals.

Orthologs for THOC5 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia THOC5 35
  • 91.56 (n)
  • 96.49 (a)
THOC5 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia THOC5 35
  • 92.44 (n)
  • 98.1 (a)
THOC5 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Thoc5 35
  • 89.8 (n)
  • 96.05 (a)
Thoc5 16
Thoc5 36
  • 96 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia THOC5 35
  • 99.56 (n)
  • 99.71 (a)
THOC5 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Thoc5 35
  • 90.37 (n)
  • 96.33 (a)
oppossum
(Monodelphis domestica)
Mammalia THOC5 36
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 70 (a)
OneToMany
-- 36
  • 86 (a)
OneToMany
chicken
(Gallus gallus)
Aves THOC5 35
  • 78.76 (n)
  • 85.02 (a)
THOC5 36
  • 85 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia THOC5 36
  • 81 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia thoc5 35
  • 70.16 (n)
  • 77.14 (a)
African clawed frog
(Xenopus laevis)
Amphibia fmip-prov 35
zebrafish
(Danio rerio)
Actinopterygii Dr.2250 35
thoc5 35
  • 66.62 (n)
  • 68.62 (a)
thoc5 36
  • 67 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004746 35
  • 45.18 (n)
  • 37.22 (a)
fruit fly
(Drosophila melanogaster)
Insecta thoc5 35
  • 44.6 (n)
  • 31.38 (a)
thoc5 36
  • 28 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea Y32H12A.2 36
  • 25 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 38 (a)
OneToOne
Species with no ortholog for THOC5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for THOC5 Gene

ENSEMBL:
Gene Tree for THOC5 (if available)
TreeFam:
Gene Tree for THOC5 (if available)

Paralogs for THOC5 Gene

No data available for Paralogs for THOC5 Gene

Variants for THOC5 Gene

Sequence variations from dbSNP and Humsavar for THOC5 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs1049534 - 29,512,083(-) CACCT(A/G)TTTTC reference, missense
VAR_035692 A breast cancer sample
VAR_035693 A breast cancer sample
rs8141153 - 29,519,072(+) CATGG(A/T)GGTCT reference, missense
rs737976 - 29,517,283(+) GGCAA(C/T)TGTCA reference, missense

Structural Variations from Database of Genomic Variants (DGV) for THOC5 Gene

Variant ID Type Subtype PubMed ID
nsv834172 CNV Loss 17160897
esv2724126 CNV Deletion 23290073
nsv510513 CNV Loss 20534489

Variation tolerance for THOC5 Gene

Residual Variation Intolerance Score: 16% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.24; 88.08% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for THOC5 Gene

HapMap Linkage Disequilibrium report
THOC5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for THOC5 Gene

Disorders for THOC5 Gene

MalaCards: The human disease database

(1) MalaCards diseases for THOC5 Gene - From: GeneCards

Disorder Aliases PubMed IDs
neurofibromatosis, type 2
  • central neurofibromatosis
- elite association - COSMIC cancer census association via MalaCards
Search THOC5 in MalaCards View complete list of genes associated with diseases

Relevant External Links for THOC5

Genetic Association Database (GAD)
THOC5
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
THOC5
genes like me logo Genes that share disorders with THOC5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for THOC5 Gene

Publications for THOC5 Gene

  1. THOC5 spliceosome protein: a target for leukaemogenic tyrosine kinases that affects inositol lipid turnover. (PMID: 18373705) Pierce A. … Whetton A.D. (Br. J. Haematol. 2008) 2 3 4 67
  2. THOC5 couples M-CSF receptor signaling to transcription factor expression. (PMID: 19015024) Carney L. … Whetton A.D. (Cell. Signal. 2009) 2 3
  3. Nuclear localization of the pre-mRNA associating protein THOC7 depends upon its direct interaction with Fms tyrosine kinase interacting protein (FMIP). (PMID: 19059247) El Bounkari O. … Tamura T. (FEBS Lett. 2009) 3 23
  4. Recruitment of the human TREX complex to mRNA during splicing. (PMID: 15998806) Masuda S. … Reed R. (Genes Dev. 2005) 2 3
  5. The M-CSF receptor substrate and interacting protein FMIP is governed in its subcellular localization by protein kinase C-mediated phosphorylation, and thereby potentiates M-CSF-mediated differentiation. (PMID: 15221008) Mancini A. … Tamura T. (Oncogene 2004) 3 23

Products for THOC5 Gene

Sources for THOC5 Gene

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