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Aliases for THOC5 Gene

Aliases for THOC5 Gene

  • THO Complex 5 2 3 5
  • Functional Spliceosome-Associated Protein 79 2 3 4
  • NF2/Meningioma Region Protein PK1.3 3 4
  • Placental Protein 39.2 3 4
  • C22orf19 3 4
  • HTREX90 3 4
  • PP39.2 3 4
  • FSAP79 3 4
  • Chromosome 22 Open Reading Frame 19 2
  • THO Complex Subunit 5 Homolog 3
  • Fms-Interacting Protein 3
  • KIAA0983 4
  • PK1.3 3
  • Fmip 3

External Ids for THOC5 Gene

Previous HGNC Symbols for THOC5 Gene

  • C22orf19

Previous GeneCards Identifiers for THOC5 Gene

  • GC00U902870
  • GC22M028231
  • GC22M029901
  • GC22M012867

Summaries for THOC5 Gene

GeneCards Summary for THOC5 Gene

THOC5 (THO Complex 5) is a Protein Coding gene. Among its related pathways are Formation of HIV elongation complex in the absence of HIV Tat and RNA Polymerase II Transcription Termination. GO annotations related to this gene include mRNA binding.

UniProtKB/Swiss-Prot for THOC5 Gene

  • Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5 end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essential for the export of Kaposis sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. THOC5 in conjunction with ALYREF/THOC4 functions in NXF1-NXT1 mediated nuclear export of HSP70 mRNA; both proteins enhance the RNA binding activity of NXF1 and are required for NXF1 localization to the nuclear rim. Involved in transcription elongation and genome stability. Involved in alternative polyadenylation site choice by recruiting CPSF6 to 5 region of target genes; probably mediates association of the TREX and CFIm complexes.

  • Regulates the expression of myeloid transcription factors CEBPA, CEBPB and GAB2 by enhancing the levels of phosphatidylinositol 3,4,5-trisphosphate. May be involved in the differentiation of granulocytes and adipocytes. Essential for hematopoietic primitive cell survival and plays an integral role in monocytic development.

Gene Wiki entry for THOC5 Gene

Additional gene information for THOC5 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for THOC5 Gene

Genomics for THOC5 Gene

Regulatory Elements for THOC5 Gene

Enhancers for THOC5 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH22H029552 1.1 ENCODE 63.4 +0.9 861 3 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF207 THOC5 EWSR1 SF3A1 TBC1D10A NIPSNAP1 ENSG00000272858 RNF215 CCDC117 RHBDD3 LOC91370
GH22H029616 1.9 FANTOM5 Ensembl ENCODE dbSUPER 35.4 -67.5 -67499 11 PKNOX1 FOXA2 SIN3A FEZF1 YY1 ZNF121 ZNF143 FOS SP3 TSHZ1 THOC5 NIPSNAP1 RNU5F-5P GAS2L1 NF2 RPEP4 PIR57472
GH22H029640 1.4 FANTOM5 Ensembl ENCODE 36.3 -86.4 -86398 1 PKNOX1 ZSCAN4 INSM2 FEZF1 ZNF366 ZSCAN5C OVOL3 TSHZ1 ZNF488 ZEB2 THOC5 RNU5F-5P SEC14L2 ENSG00000249590 NF2 NIPSNAP1 MTMR3 PIR57472 RPEP4
GH22H029587 0.9 Ensembl ENCODE 53 -32.9 -32909 1 ZNF3 FOXA2 SAP130 MLX FOXA3 MNT TGIF2 JUND FOXK2 FOS THOC5 GAS2L1 NIPSNAP1 NF2
GH22H029479 1.5 FANTOM5 Ensembl ENCODE 27.8 +74.5 74520 4 ATF1 SIN3A BRCA1 ZNF766 GLIS2 ATF7 SP3 NCOA1 MIER2 REST THOC5 RFPL1 RNF215 RASL10A EWSR1 NEFH NIPSNAP1 ENSG00000282816
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around THOC5 on UCSC Golden Path with GeneCards custom track

Promoters for THOC5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000145072 1715 1800 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF143

Genomic Location for THOC5 Gene

Chromosome:
22
Start:
29,505,879 bp from pter
End:
29,555,216 bp from pter
Size:
49,338 bases
Orientation:
Minus strand

Genomic View for THOC5 Gene

Genes around THOC5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
THOC5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for THOC5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for THOC5 Gene

Proteins for THOC5 Gene

  • Protein details for THOC5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13769-THOC5_HUMAN
    Recommended name:
    THO complex subunit 5 homolog
    Protein Accession:
    Q13769
    Secondary Accessions:
    • O60839
    • Q9UPZ5

    Protein attributes for THOC5 Gene

    Size:
    683 amino acids
    Molecular mass:
    78508 Da
    Quaternary structure:
    • Interacts with phosphorylated CSF1R (By similarity). Component of the THO complex, which is composed of THOC1, THOC2, THOC3, THOC5, THOC6 and THOC7; together with at least ALYREF/THOC4, DDX39B, SARNP/CIP29 and CHTOP, THO forms the transcription/export (TREX) complex which seems to have a dynamic structure involving ATP-dependent remodeling. Interacts with ALYREF/THOC4, and THOC7. Interacts (via N-terminus) with the NTF2 domain of NXF1. Forms a complex with CEBPB. Interacts with CPSF6; indicative for an association with the cleavage factor Im (CFIm) complex. Interacts with THOC1 (By similarity). Interacts with LUZP4. Interacts with NCBP3 (PubMed:26382858).
    SequenceCaution:
    • Sequence=BAA76827.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for THOC5 Gene

Post-translational modifications for THOC5 Gene

  • Phosphorylated on tyrosine upon binding to activated CSF1R; which causes a dissociation of the two proteins. Phosphorylation on Ser-5 and/or Ser-6 is required for nuclear export. Phosphorylated on Thr-328 in insulin-stimulated adipocytes (By similarity). Phosphorylation at Tyr-225 modulates mRNA binding.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for THOC5 Gene

Domains & Families for THOC5 Gene

Gene Families for THOC5 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for THOC5 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for THOC5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q13769

UniProtKB/Swiss-Prot:

THOC5_HUMAN :
  • Belongs to the THOC5 family.
Family:
  • Belongs to the THOC5 family.
genes like me logo Genes that share domains with THOC5: view

Function for THOC5 Gene

Molecular function for THOC5 Gene

UniProtKB/Swiss-Prot Function:
Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5 end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essential for the export of Kaposis sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. THOC5 in conjunction with ALYREF/THOC4 functions in NXF1-NXT1 mediated nuclear export of HSP70 mRNA; both proteins enhance the RNA binding activity of NXF1 and are required for NXF1 localization to the nuclear rim. Involved in transcription elongation and genome stability. Involved in alternative polyadenylation site choice by recruiting CPSF6 to 5 region of target genes; probably mediates association of the TREX and CFIm complexes.
UniProtKB/Swiss-Prot Function:
Regulates the expression of myeloid transcription factors CEBPA, CEBPB and GAB2 by enhancing the levels of phosphatidylinositol 3,4,5-trisphosphate. May be involved in the differentiation of granulocytes and adipocytes. Essential for hematopoietic primitive cell survival and plays an integral role in monocytic development.

Phenotypes From GWAS Catalog for THOC5 Gene

Gene Ontology (GO) - Molecular Function for THOC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IEA --
GO:0003729 mRNA binding IBA --
GO:0005515 protein binding IPI 19059247
genes like me logo Genes that share ontologies with THOC5: view
genes like me logo Genes that share phenotypes with THOC5: view

Animal Models for THOC5 Gene

MGI Knock Outs for THOC5:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for THOC5 Gene

Localization for THOC5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for THOC5 Gene

Nucleus. Cytoplasm. Note=Shuttles between nucleus and cytoplasm. {ECO:0000269 PubMed:19059247}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for THOC5 gene
Compartment Confidence
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for THOC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000346 transcription export complex IDA 15833825
GO:0000347 THO complex IDA 15998806
GO:0000445 THO complex part of transcription export complex IDA 15998806
GO:0000784 colocalizes_with nuclear chromosome, telomeric region IDA 24270157
GO:0005634 nucleus IDA,IEA 19059247
genes like me logo Genes that share ontologies with THOC5: view

Pathways & Interactions for THOC5 Gene

genes like me logo Genes that share pathways with THOC5: view

SIGNOR curated interactions for THOC5 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for THOC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006369 termination of RNA polymerase II transcription TAS --
GO:0006397 mRNA processing IEA --
GO:0006405 RNA export from nucleus TAS --
GO:0006406 mRNA export from nucleus TAS --
GO:0006810 transport IEA --
genes like me logo Genes that share ontologies with THOC5: view

Drugs & Compounds for THOC5 Gene

No Compound Related Data Available

Transcripts for THOC5 Gene

Unigene Clusters for THOC5 Gene

THO complex 5:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for THOC5 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24a ·
SP1: - -
SP2: - - - - -
SP3: - -
SP4: -
SP5:

ExUns: 24b
SP1:
SP2:
SP3:
SP4:
SP5:

Relevant External Links for THOC5 Gene

GeneLoc Exon Structure for
THOC5
ECgene alternative splicing isoforms for
THOC5

Expression for THOC5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for THOC5 Gene

mRNA differential expression in normal tissues according to GTEx for THOC5 Gene

This gene is overexpressed in Whole Blood (x4.7).

Protein differential expression in normal tissues from HIPED for THOC5 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (21.1) and Lymph node (7.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for THOC5 Gene



Protein tissue co-expression partners for THOC5 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of THOC5 Gene:

THOC5

SOURCE GeneReport for Unigene cluster for THOC5 Gene:

Hs.75361

mRNA Expression by UniProt/SwissProt for THOC5 Gene:

Q13769-THOC5_HUMAN
Tissue specificity: Ubiquitously expressed.

Evidence on tissue expression from TISSUES for THOC5 Gene

  • Nervous system(4.8)
  • Liver(4.3)
  • Intestine(4.2)
genes like me logo Genes that share expression patterns with THOC5: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for THOC5 Gene

Orthologs for THOC5 Gene

This gene was present in the common ancestor of animals.

Orthologs for THOC5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia THOC5 33 34
  • 99.56 (n)
dog
(Canis familiaris)
Mammalia THOC5 33 34
  • 92.44 (n)
cow
(Bos Taurus)
Mammalia THOC5 33 34
  • 91.56 (n)
rat
(Rattus norvegicus)
Mammalia Thoc5 33
  • 90.37 (n)
mouse
(Mus musculus)
Mammalia Thoc5 33 16 34
  • 89.8 (n)
oppossum
(Monodelphis domestica)
Mammalia THOC5 34
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 86 (a)
OneToMany
-- 34
  • 70 (a)
OneToMany
chicken
(Gallus gallus)
Aves THOC5 33 34
  • 78.76 (n)
lizard
(Anolis carolinensis)
Reptilia THOC5 34
  • 81 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia thoc5 33
  • 70.16 (n)
African clawed frog
(Xenopus laevis)
Amphibia fmip-prov 33
zebrafish
(Danio rerio)
Actinopterygii thoc5 33 34
  • 66.62 (n)
Dr.2250 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004746 33
  • 45.18 (n)
fruit fly
(Drosophila melanogaster)
Insecta thoc5 33 34
  • 44.6 (n)
worm
(Caenorhabditis elegans)
Secernentea Y32H12A.2 34
  • 25 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 38 (a)
OneToOne
Species where no ortholog for THOC5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for THOC5 Gene

ENSEMBL:
Gene Tree for THOC5 (if available)
TreeFam:
Gene Tree for THOC5 (if available)

Paralogs for THOC5 Gene

No data available for Paralogs for THOC5 Gene

Variants for THOC5 Gene

Sequence variations from dbSNP and Humsavar for THOC5 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
VAR_035692 A breast cancer sample
VAR_035693 A breast cancer sample
rs1000005684 -- 29,547,935(+) TCCAC(A/G)TGGCT intron-variant
rs1000159417 -- 29,522,593(+) AAAAA(C/T)GATGA intron-variant
rs1000169030 -- 29,514,571(+) TCGGC(C/T)TCCCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for THOC5 Gene

Variant ID Type Subtype PubMed ID
esv2724126 CNV deletion 23290073
esv3568351 CNV loss 25503493
esv3647536 CNV gain 21293372
esv3647538 CNV gain 21293372
esv3647539 CNV gain 21293372
esv3893473 CNV loss 25118596
nsv1110864 OTHER inversion 24896259
nsv510513 OTHER sequence alteration 20534489
nsv834172 CNV loss 17160897

Variation tolerance for THOC5 Gene

Residual Variation Intolerance Score: 16% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.24; 88.08% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for THOC5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
THOC5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for THOC5 Gene

Disorders for THOC5 Gene

Relevant External Links for THOC5

Genetic Association Database (GAD)
THOC5
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
THOC5

No disorders were found for THOC5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for THOC5 Gene

Publications for THOC5 Gene

  1. Nuclear localization of the pre-mRNA associating protein THOC7 depends upon its direct interaction with Fms tyrosine kinase interacting protein (FMIP). (PMID: 19059247) El Bounkari O … Tamura T (FEBS letters 2009) 3 4 22 60
  2. THOC5 spliceosome protein: a target for leukaemogenic tyrosine kinases that affects inositol lipid turnover. (PMID: 18373705) Pierce A … Whetton AD (British journal of haematology 2008) 2 3 4 60
  3. Recruitment of the human TREX complex to mRNA during splicing. (PMID: 15998806) Masuda S … Reed R (Genes & development 2005) 2 3 4 60
  4. Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10231032) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1999) 2 3 4 60
  5. Cloning of a novel, anonymous gene from a megabase-range YAC and cosmid contig in the neurofibromatosis type 2/meningioma region on human chromosome 22q12. (PMID: 8242058) Xie YG … Dumanski JP (Human molecular genetics 1993) 2 3 4 60

Products for THOC5 Gene

Sources for THOC5 Gene

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