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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

THOC5 Gene

protein-coding   GIFtS: 53
GCID: GC22M029901

THO complex 5

(Previous name: chromosome 22 open reading frame 19 )
(Previous symbol: C22orf19)
 Explore 8 diseases affiliated with
THOC5 via our new
 Human Malady Compendium 
Biological research products
for THOC5
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
THO Complex 51 2     PP39.22 3
C22orf191 2 3     HTREX901
FSAP791     NF2/Meningioma Region Protein PK1.32 3
Fmip1 2     Chromosome 22 Open Reading Frame 191
PK1.31 2     Fms-Interacting Protein2
KIAA09831 3     THO Complex Subunit 5 Homolog2
Functional Spliceosome-Associated Protein 792 3     FMIP5
Placental Protein 39.22 3     

External Ids:    HGNC: 190741   Entrez Gene: 85632   Ensembl: ENSG000001002967   OMIM: 6127335   UniProtKB: Q137693   

Export aliases for THOC5 gene to outside databases

Previous GC identifers: GC00U902870 GC22M028231 GC22M012867


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: THOC5_HUMAN, Q13769
Function: Component the THO subcomplex of the TREX complex. The TREX complex specifically associates with spliced mRNA
and not with unspliced pre-mRNA. It is recruited to spliced mRNAs by a transcription-independent mechanism. Binds to
mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region
near the 5' end of the mRNA where it functions in mRNA export. The recruitment occurs via an interaction between
ALYREF/THOC4 and the cap-binding protein NCBP1. The TREX complex is essential for the export of Kaposi's
sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. The recruitment of the TREX
complex to the intronless viral mRNA occurs via an interaction beteen KSHV ORF57 protein and ALYREF/THOC4. DDX39B
functions as a bridge between ALYREF/THOC4 and the THO complex. THOC5 in conjunction with ALYREF/THOC4 functions in
NXF1-NXT1 mediated nuclear export of HSP70 mRNA. Regulates the expression of myeloid transcription factors CEBPA,
CEBPB and GAB2 by enhancing the levels of phosphatidylinositol 3,4,5-trisphosphate. May be involved in the
differentiation of granulocytes and adipocytes. Essential for hematopoietic primitive cell survival and plays an
integral role in monocytic development

Gene Wiki entry for THOC5


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000022.10  NC_018933.1  NT_011520.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the THOC5 gene promoter:
         p53   ZID   Tal-1beta   E47   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTHOC5 promoter sequence
   Search SABiosciences Chromatin IP Primers for THOC5

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat THOC5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q12.2   Ensembl cytogenetic band:  22q12.2   HGNC cytogenetic band: 22q12

THOC5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
THOC5 gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22M029901:  view genomic region     (about GC identifiers)

Start:
29,901,868 bp from pter      End:
29,951,205 bp from pter
Size:
49,338 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: THOC5_HUMAN, Q13769 (See protein sequence)
Recommended Name: THO complex subunit 5 homolog  
Size: 683 amino acids; 78508 Da
Subunit: Interacts with phosphorylated CSF1R and THOC1 (By similarity). Component of the THO complex, which is composed
of THOC1, THOC2, THOC5, THOC6 and THOC7. Together with THOC3, ALYREF/THOC4 and DDX39B, THO forms the
transcription/export (TREX) complex. Interacts with ALYREF/THOC4 and THOC7. Interacts (via N-terminus) with the NTF2
domain of NXF1. Forms a complex with CEBPB (By similarity)
Subcellular location: Nucleus. Cytoplasm (By similarity). Note=Shuttles between nucleus and cytoplasm
Sequence caution: Sequence=BAA76827.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: O60839 Q9UPZ5

Explore the universe of human proteins at neXtProt for THOC5: NX_Q13769

Post-translational modifications:

  • Phosphorylated on tyrosine upon binding to activated CSF1R; which causes a dissociation of the two proteins.
  • Phosphorylation on Ser-5 and/or Ser-6 is required for nuclear export. Phosphorylated on Thr-328 in insulin-stimulated
    adipocytes (By similarity)1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q13769

  • THOC5 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (4 alternative transcripts): 
    NP_001002877.1  NP_001002878.1  NP_001002879.1  NP_003669.4  

    ENSEMBL proteins: 
     ENSP00000420306   ENSP00000416500   ENSP00000444493   ENSP00000380971   ENSP00000393247  
     ENSP00000413505   ENSP00000415425   ENSP00000416804   ENSP00000393420   ENSP00000388039  
     ENSP00000380970   ENSP00000380969  

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    Uscn Proteins for THOC5

    Gene Ontology (GO): 5/8 cellular component terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000346transcription export complex IDA15833825
    GO:0000347THO complex IDA15998806
    GO:0000445THO complex part of transcription export complex IDA15998806
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--


    THOC5 for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    THOC5 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR019163 THO_Thoc5

    Graphical View of Domain Structure for InterPro Entry Q13769

    ProtoNet protein and cluster: Q13769

    UniProtKB/Swiss-Prot: THOC5_HUMAN, Q13769
    Similarity: Belongs to the THOC5 family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: THOC5_HUMAN, Q13769
    Function: Component the THO subcomplex of the TREX complex. The TREX complex specifically associates with spliced mRNA
    and not with unspliced pre-mRNA. It is recruited to spliced mRNAs by a transcription-independent mechanism. Binds to
    mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region
    near the 5' end of the mRNA where it functions in mRNA export. The recruitment occurs via an interaction between
    ALYREF/THOC4 and the cap-binding protein NCBP1. The TREX complex is essential for the export of Kaposi's
    sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. The recruitment of the TREX
    complex to the intronless viral mRNA occurs via an interaction beteen KSHV ORF57 protein and ALYREF/THOC4. DDX39B
    functions as a bridge between ALYREF/THOC4 and the THO complex. THOC5 in conjunction with ALYREF/THOC4 functions in
    NXF1-NXT1 mediated nuclear export of HSP70 mRNA. Regulates the expression of myeloid transcription factors CEBPA,
    CEBPB and GAB2 by enhancing the levels of phosphatidylinositol 3,4,5-trisphosphate. May be involved in the
    differentiation of granulocytes and adipocytes. Essential for hematopoietic primitive cell survival and plays an
    integral role in monocytic development

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    Inhib. RNA
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    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003723RNA binding IEA--
    GO:0005515protein binding IPI19059247


    THOC5 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for THOC5:
     Lamellipodia cells 

    Animal Models:
         Mouse knock-out Thoc5tm1.1Tate for THOC5
         5 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Thoc5):
     cellular  hematopoietic system  immune system  liver/biliary system  mortality/aging 

    THOC5 for phenotypes           About GeneDecksing


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1RNA transport
    RNA transport1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways



    1         Kegg Pathway  (Kegg details for THOC5):
        RNA transport


    THOC5 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for THOC5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 18)

    5/20 Interacting proteins for THOC5 (Q137692, 3 ENSP000003809694) via UniProtKB, MINT, STRING, and/or I2D (see all 20)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    THOC1Q96FV92, 3, ENSP000002616004MINT-6800052 MINT-6800071 MINT-7040368 MINT-7040334 MINT-7040353 MINT-6800089 MINT-7040173 MINT-8337959 I2D: score=1 STRING: ENSP00000261600
    THOC7Q6I9Y22, 3, ENSP000002958994MINT-6800108 MINT-6800071 MINT-6799973 MINT-6800005 MINT-6799962 MINT-6800089 MINT-6799989 I2D: score=2 STRING: ENSP00000295899
    TAP1Q035182, 3, ENSP000003462064MINT-7040083 MINT-7040151 MINT-7033707 MINT-7040125 MINT-7040261 I2D: score=1 STRING: ENSP00000346206
    THOC6Q86W422, ENSP000003265314MINT-7040334 MINT-7040353 MINT-7040368 STRING: ENSP00000326531
    ALYREFQ86V812, ENSP000003318174MINT-7040173 MINT-7040261 STRING: ENSP00000331817
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006397mRNA processing IEA--
    GO:0006406mRNA export from nucleus IDA17190602
    GO:0008380RNA splicing IEA--
    GO:0030224monocyte differentiation IDA19015024
    GO:0045650negative regulation of macrophage differentiation IEA--


    THOC5 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for THOC5
    Search CenterWatch for drugs/clinical trials and news about THOC5 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for THOC5 gene (4 alternative transcripts): 
    NM_001002877.1  NM_001002878.1  NM_001002879.1  NM_003678.4  

    Unigene Cluster for THOC5:

    THO complex 5
    Hs.75361  [show with all ESTs]
    Unigene Representative Sequence: AB023200
    17 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000490103(uc003afq.3 uc003afu.3) ENST00000442555(uc003afv.1)
    ENST00000472164 ENST00000358079 ENST00000397873 ENST00000484924 ENST00000443089
    ENST00000492707 ENST00000488052 ENST00000475187(uc003afw.1) ENST00000440771
    ENST00000455450 ENST00000428374 ENST00000414902 ENST00000418021 ENST00000397872(uc003afr.3 uc003aft.3)
    ENST00000397871(uc003afs.3)

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    Additional cDNA sequence: 

    AB023200.1 AJ006069.1 AK025385.1 AK098709.1 AK122673.1 AK225169.1 AK225752.1 BC003615.2 
    CR456542.1 

    20 DOTS entries:

    DT.40286962  DT.412150  DT.100758416  DT.100803549  DT.100815593  DT.120651437  DT.120651427  DT.100687777 
    DT.95303703  DT.92438295  DT.120651401  DT.97848428  DT.95303704  DT.100815587  DT.100815589  DT.120651434 
    DT.120651343  DT.120651429  DT.40209926  DT.92069719 

    24/761 AceView cDNA sequences (see all 761):

    CF140265 AI460012 BU539274 AI349460 BQ649847 Z40980 AW197176 AW340285 
    Z98516 F11739 CR598880 CB159722 AI538702 BC006473 BQ004568 BM457603 
    AV645951 CR623297 BU191992 BF968938 BQ185814 BM675020 BM705613 BQ440046 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for THOC5    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24a ·
    SP1:              -     -                                                                                                                                       
    SP2:              -     -     -                                               -                 -                                                               
    SP3:                                                                    -     -                                                                                 
    SP4:                          -                                                                                                                                 
    SP5:                                                                                                                                                            

    ExUns: 24b
    SP1:      
    SP2:      
    SP3:      
    SP4:      
    SP5:      


    ECgene alternative splicing isoforms for THOC5

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    THOC5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TGACTCTTGA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See THOC5 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for THOC5

    SOURCE GeneReport for Unigene cluster: Hs.75361

    UniProtKB/Swiss-Prot: THOC5_HUMAN, Q13769
    Tissue specificity: Ubiquitously expressed

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for THOC5 gene from 9/26 species (see all 26)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Thoc51 , 5 THO complex 51, 5 89.8(n)1
    96.05(a)1
      11 (3.09 cM)5
    1078291  NM_172438.31  NP_766026.11 
     48953205 
    chicken
    (Gallus gallus)
    Aves THOC51 THO complex 5 78.76(n)
    85.02(a)
      417019  NM_001006195.1  NP_001006195.1 
    lizard
    (Anolis carolinensis)
    Reptilia THOC56
    --
    81(a)
    1 ↔ 1
    GL343417.1(53881-60829)
    African clawed frog
    (Xenopus laevis)
    Amphibia fmip-prov2 Fms interacting protein 75.52(n)    BC045075.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.22502 Danio rerio mRNA similar to Fms interacting protein more 76.45(n)    BC045980.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta thoc56
    thoc5
    28(a)
    1 ↔ 1
    2R(19841616-19843930)
    worm
    (Caenorhabditis elegans)
    Secernentea Y32H12A.26
    --
    23(a)
    1 ↔ 1
    III(5346094-5349454)
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons THO51 THO complex, subunit 5 43.59(n)
    32.75(a)
      834304  NM_203144.3  NP_974873.1 
    rice
    (Oryza sativa)
    Liliopsida Os02g07671001 hypothetical protein 46(n)
    33.33(a)
      4330841  NM_001054763.1  NP_001048228.1 


    ENSEMBL Gene Tree for THOC5 (if available)
    TreeFam Gene Tree for THOC5 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/834 NCBI SNPs in THOC5 are shown (see all 834    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 22 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs770367941,2
    F,--29903837(+) ATACAC/TGGATT 4 -- ds50011Minor allele frequency- T:0.10WA 118
    rs1445201741,2
    --29903838(+) TACACA/GGATTT 4 -- ds50010--------
    rs1491966621,2
    --29903980(+) ATCGGC/TAACCC 4 -- ds50010--------
    rs1433223541,2
    --29904007(+) AAGAGC/TGGGTG 4 -- ds50010--------
    rs1512827371,2
    --29904023(+) GGAAGA/GGTTTT 4 -- ds50010--------
    rs1416252261,2
    --29904143(+) GTGTGC/TGTAGA 4 -- ds50010--------
    rs1819061521,2
    --29904248(+) ACTGTC/GTCACA 4 -- ut310--------
    rs10495361,2
    C,F,O,H,--29904354(-) ATATTC/TTCCAA 4 -- ut3129Minor allele frequency- T:0.13MN EA NA NS 2888
    rs169877281,2
    C,F,H,--29904356(+) GGAGAA/GTATCA 4 -- ut319Minor allele frequency- G:0.05NA NS EA WA CSA 560
    rs1995512041,2
    --29904417(+) AGGCCC/TTGGGG 4 -- ut310--------

    HapMap Linkage Disequilibrium report for THOC5 (29901868 - 29951205 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for THOC5: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing THOC5
    DNA2.0 Custom Variant and Variant Library Synthesis for THOC5

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    THOC5 for disorders           About GeneDecksing

    OMIM gene information: 612733    OMIM disorders: --

    8 diseases for THOC5:    About MalaCards
    meningioma    ataxia telangiectasia    kaposi's sarcoma    neurofibromatosis
    conjunctivitis    ataxia    sarcoma    breast cancer


    Export disorders for THOC5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for THOC5 gene, integrated from 9 sources (see all 36):
    (articles sorted by number of sources associating them with THOC5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. THOC5 spliceosome protein: a target for leukaemogenic tyrosine kinases that affects inositol lipid turnover. (PubMed id 18373705)1, 2, 3 Pierce A....Whetton A.D. (2008)
    2. Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10231032)1, 2, 3 Nagase T.... Ohara O. (1999)
    3. Cloning of a novel, anonymous gene from a megabase-range YAC and cosmid contig in the neurofibromatosis type 2/meningioma region on human chromosome 22q12. (PubMed id 8242058)1, 2, 3 Xie Y.G.... Dumanski J.P. (1993)
    4. Nuclear localization of the pre-mRNA associating protein THOC7 depends upon its direct interaction with Fms tyrosine kinase interacting protein (FMIP). (PubMed id 19059247)1, 2, 9 El Bounkari O.... Tamura T. (2009)
    5. Adaptor Aly and co-adaptor Thoc5 function in the Tap-p15-mediated nuclear export of HSP70 mRNA. (PubMed id 19165146)1, 2 Katahira J.... Yoneda Y. (2009)
    6. THOC5 couples M-CSF receptor signaling to transcription factor expression. (PubMed id 19015024)1, 3 Carney L....Whetton A.D. (2009)
    7. Recruitment of the complete hTREX complex is required for Kaposi's sarcoma-associated herpesvirus intronless mRNA nuclear export and virus replication. (PubMed id 18974867)1, 2 Boyne J.R.... Whitehouse A. (2008)
    8. Human mRNA export machinery recruited to the 5' end of mRNA. (PubMed id 17190602)1, 2 Cheng H.... Reed R. (2006)
    9. Recruitment of the human TREX complex to mRNA during splicing. (PubMed id 15998806)1, 2 Masuda S.... Reed R. (2005)
    10. Linking transcriptional elongation and messenger RNA export to metastatic breast cancers. (PubMed id 15833825)1, 2 Guo S.... Shiekhattar R. (2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8563 HGNC: 19074 AceView: NIPSNAP1andC22orf19 Ensembl:ENSG00000100296 euGenes: HUgn8563
    ECgene: THOC5 Kegg: 8563 H-InvDB: THOC5

    (According to HUGE)
    About This Section
    HUGE: KIAA0983

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for THOC5 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for THOC5 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for THOC5 gene:
    Search GeneIP for patents involving THOC5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
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     Regulatory tfbs in THOC5 promoter
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