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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

THOC3 Gene

protein-coding   GIFtS: 50
GCID: GC05M175344

THO Complex 3

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
THO Complex 31 2     THO Complex Subunit 32
hTREX452 3     Tho33
TEX1 Homolog2 3     TEX15
THO32     

External Ids:    HGNC: 190721   Entrez Gene: 843212   Ensembl: ENSG000000515967   OMIM: 6069295   UniProtKB: Q96J013   

Export aliases for THOC3 gene to outside databases

Previous GC identifers: GC05M176207 GC05M175280 GC05M175367 GC05M175319 GC05P172063


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for THOC3 Gene:
This gene encodes a component of the nuclear THO transcription elongation complex, which is part of the larger
transcription export (TREX) complex that couples messenger RNA processing and export. In humans, the
transcription export complex is recruited to the 5'-end of messenger RNAs in a splicing- and cap-dependent
manner. Studies of a related complex in mouse suggest that the metazoan transcription export complex is involved
in cell differentiation and development. A pseudogene of this gene has been defined on chromosome 5. (provided by
RefSeq, May 2013)

GeneCards Summary for THOC3 Gene: 
THOC3 (THO complex 3) is a protein-coding gene. Diseases associated with THOC3 include kaposi's sarcoma, and sarcoma, and among its related super-pathways are mRNA Splicing - Major Pathway. GO annotations related to this gene include RNA binding.

UniProtKB/Swiss-Prot: THOC3_HUMAN, Q96J01
Function: Component of the THO subcomplex of the TREX complex. The TREX complex specifically associates with
spliced mRNA and not with unspliced pre-mRNA. It is recruited to spliced mRNAs by a transcription-independent
mechanism. Binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and
cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export. The recruitment
occurs via an interaction between ALYREF/THOC4 and the cap-binding protein NCBP1. DDX39B functions as a bridge
between ALYREF/THOC4 and the THO complex. The TREX complex is essential for the export of Kaposi's
sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. The recruitment of the
TREX complex to the intronless viral mRNA occurs via an interaction between KSHV ORF57 protein and ALYREF/THOC4




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NC_018916.2  NT_023133.13  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the THOC3 gene promoter:
         RP58   Pax-5   Pbx1a   c-Ets-1   E47   RORalpha1   NRF-2   ARP-1   Sox9   Hand1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for THOC3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat THOC3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q35.2   Ensembl cytogenetic band:  5q35.2   HGNC cytogenetic band: 5q35.3

THOC3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
THOC3 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M175344:  view genomic region     (about GC identifiers)

Start:
175,344,876 bp from pter      End:
175,461,683 bp from pter
Size:
116,808 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: THOC3_HUMAN, Q96J01 (See protein sequence)
Recommended Name: THO complex subunit 3  
Size: 351 amino acids; 38772 Da
Subunit: Component of the THO complex, which is composed of THOC1, THOC2, THOC5, THOC6 and THOC7. Together with
THOC3, ALYREF/THOC4 and DDX39B, THO forms the transcription/export (TREX) complex
Subcellular location: Nucleus (Probable)
Caution: There are two almost identical copies of this gene on chromosome 5q35. One copy is frameshifted and
unlikely to encode a functional protein

Explore the universe of human proteins at neXtProt for THOC3: NX_Q96J01

Explore proteomics data for THOC3 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q96J01

  • THOC3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    THOC3 Protein Expression
    REFSEQ proteins: NP_115737.1  
    ENSEMBL proteins: 
     ENSP00000394166   ENSP00000425781   ENSP00000265097   ENSP00000424967   ENSP00000425039  
     ENSP00000422243   ENSP00000427029   ENSP00000421082   ENSP00000427267  

    Human Recombinant Protein Products for THOC3: 
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    Novus Biologicals THOC3 Proteins
    Novus Biologicals THOC3 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000346transcription export complex IDA15833825

    THOC3 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    WDR: WD repeat domain containing
    THOC: THO complex subunits

    5 InterPro protein domains:
     IPR001680 WD40_repeat
     IPR020472 G-protein_beta_WD-40_rep
     IPR011659 PD40
     IPR017986 WD40_repeat_dom
     IPR015943 WD40/YVTN_repeat-like_dom

    Graphical View of Domain Structure for InterPro Entry Q96J01

    ProtoNet protein and cluster: Q96J01

    UniProtKB/Swiss-Prot: THOC3_HUMAN, Q96J01
    Similarity: Contains 6 WD repeats


    THOC3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: THOC3_HUMAN, Q96J01
    Function: Component of the THO subcomplex of the TREX complex. The TREX complex specifically associates with
    spliced mRNA and not with unspliced pre-mRNA. It is recruited to spliced mRNAs by a transcription-independent
    mechanism. Binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and
    cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export. The recruitment
    occurs via an interaction between ALYREF/THOC4 and the cap-binding protein NCBP1. DDX39B functions as a bridge
    between ALYREF/THOC4 and the THO complex. The TREX complex is essential for the export of Kaposi's
    sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. The recruitment of the
    TREX complex to the intronless viral mRNA occurs via an interaction between KSHV ORF57 protein and ALYREF/THOC4

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003723RNA binding IEA--
    GO:0005515protein binding ----
         
    THOC3 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for THOC3:
     Decreased viability of wild-ty  Increased S DNA content 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for THOC3 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for THOC3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for THOC3 
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    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for THOC3 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1mRNA Splicing - Major Pathway
    Spliceosome0.31
    2RNA transport
    RNA transport

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    2         Kegg Pathways  (Kegg details for THOC3):
        RNA transport
    Spliceosome


    THOC3 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for THOC3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 12)

    5/13 Interacting proteins for THOC3 (Q96J012, 3 ENSP000002650974) via UniProtKB, MINT, STRING, and/or I2D (see all 13)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TK1P041832, 3MINT-8274181 I2D: score=2 
    YOD1Q5VVQ63, ENSP000003268134I2D: score=2 STRING: ENSP00000326813
    ALYREFENSP000003318174STRING: ENSP00000331817
    THOC5ENSP000003809694STRING: ENSP00000380969
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006397mRNA processing IEA--
    GO:0006406mRNA export from nucleus IDA17190602
    GO:0008380RNA splicing IEA--
    GO:0046784intronless viral mRNA export from host nucleus IDA18974867

    THOC3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for THOC3

    Search CenterWatch for drugs/clinical trials and news about THOC3

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for THOC3 gene: 
    NM_032361.3  

    Unigene Cluster for THOC3:

    THO complex 3
    Hs.484227  [show with all ESTs]
    Unigene Representative Sequence: NM_032361
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000432305 ENST00000515016 ENST00000265097(uc003mdg.4) ENST00000505969
    ENST00000514861 ENST00000513482(uc003mdh.3) ENST00000510300 ENST00000511062
    ENST00000513118 ENST00000513006 ENST00000514250
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    4 QIAGEN miScript miRNA Assays for microRNAs that regulate THOC3:
    hsa-miR-520d-5p hsa-miR-524-5p hsa-miR-616* hsa-miR-373*
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Browse for Gene Knock-down Tools from EMD Millipore
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    GenScript: all cDNA clones in your preferred vector: THOC3 (NM_032361)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for THOC3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat THOC3
    Sirion Biotech Customized lentivirus for stable overexpression of THOC3 
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat THOC3

    Additional mRNA sequence: 

    BC006849.1 BC066325.1 BC068499.1 

    15 DOTS entries:

    DT.448496  DT.100876911  DT.101977844  DT.102825306  DT.100876909  DT.100759679  DT.100876914  DT.120866698 
    DT.120866744  DT.91674961  DT.95369043  DT.95369048  DT.100031121  DT.120863596  DT.120866741 

    24/457 AceView cDNA sequences (see all 457):

    CR619858 BU932085 CR609602 BX114549 CR614228 BF792873 CF528640 BE277147 
    CR596017 BI258858 BU855755 BQ922349 BQ064795 BU634063 BM452096 BM667103 
    CR606947 BE746989 BQ067473 BQ012671 BM785154 CR618886 BM729309 BM718078 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for THOC3 (see all 6)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6a · 6b · 6c ^ 7a · 7b
    SP1:              -                       -                             -     -               
    SP2:              -                       -                                                   
    SP3:                                      -                                                   
    SP4:                                      -                                   -               
    SP5:              -     -                 -                                                   


    ECgene alternative splicing isoforms for THOC3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    THOC3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAAGTTTTTT
    THOC3 Expression
    About this image


    See THOC3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for THOC3

    SOURCE GeneReport for Unigene cluster: Hs.484227
        SABiosciences Custom PCR Arrays for THOC3
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for THOC3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for THOC3 gene from 10/24 species (see all 24)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Thoc31 , 5 THO complex 31, 5 89.08(n)1
    98.86(a)1
      13 (28.69 cM)5
    736661  NM_028597.31  NP_082873.21 
     544588375 
    chicken
    (Gallus gallus)
    Aves THOC31 THO complex 3 83.75(n)
    94.37(a)
      416232  NM_001030611.1  NP_001025782.1 
    lizard
    (Anolis carolinensis)
    Reptilia THOC36
    Uncharacterized protein
    94(a)
    1 ↔ 1
    GL343548.1(410674-419279)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.223122 Xenopus laevis transcribed sequence with moderate similarity to protein refNP_115737.1 (H.sapiens) hypothetical protein MGC5469 [Homo sapiens] less 82.23(n)    CA974741.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.133332 Transcribed sequence with strong similarity to protein refNP_115737.1 (H.sapiens) hypothetical protein MGC5469 [Homo sapiens] less 80.47(n)    57047699 
    fruit fly
    (Drosophila melanogaster)
    Insecta tex1 CG9615-PA 64.28(n)
    64.17(a)
      40983  NM_141527.2  NP_649784.1 
    worm
    (Caenorhabditis elegans)
    Secernentea thoc-36
    Protein THOC-3
    33(a)
    1 ↔ 1
    I(8971137-8973042)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes TEX1(YNL253W)4 Protein involved in mRNA export, component of the transcription export (TREX) complex less   --   14(170018-171286) 855468  NP_014146.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons TEX11 THO complex subunit 3 55.89(n)
    50.17(a)
      835712  NM_124995.4  NP_200424.1 
    rice
    (Oryza sativa)
    Liliopsida Os09g02984001 hypothetical protein 55.03(n)
    49.15(a)
      4346657  NM_001069344.1  NP_001062809.1 


    ENSEMBL Gene Tree for THOC3 (if available)
    TreeFam Gene Tree for THOC3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for THOC3 gene
    3 SIMAP similar genes for THOC3 using alignment to 9 protein entries:     THOC3_HUMAN (see all proteins):
    RBBP4    POC1B    KATNB1

    THOC3 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for THOC3
    PGOHUM00000251399 PGOHUM00000251400


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/137 SNPs in THOC3 are shown (see all 137)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1901779701,2
    --175386277(+) TTTCCA/TTGAGG 1 -- int10--------
    rs1396376521,2
    --175386320(+) GCTAAA/CTGACT 1 -- int10--------
    rs1148763701,2
    F--175386362(+) TCAGAG/ACCAAA 1 -- int11Minor allele frequency- A:0.02WA 118
    rs556615321,2
    C,F--175386586(+) TATATG/ATATAT 1 -- ut312Minor allele frequency- A:0.14WA NA 238
    rs3703335001,2
    C--175386734(+) GTATGC/GGGGGT 1 -- ut310--------
    rs1452056251,2
    --175386765(+) TCCACA/GCGAGT 1 -- ut310--------
    rs1476377421,2
    C--175386828(+) AAGAAC/TGAAAT 1 -- ut310--------
    rs2012190881,2
    C,F--175387011(+) GTTCCG/AGCTTC 2 /A syn11Minor allele frequency- A:0.00EU 1229
    rs797203331,2
    C,F--175387139(+) CCCTAT/CAGAAA 1 -- int12Minor allele frequency- C:0.13NA EU 1053
    rs1422718211,2
    C--175387206(+) TTACCA/TGTATT 1 -- int10--------

    HapMap Linkage Disequilibrium report for THOC3 (175344876 - 175461683 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for THOC3:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv883125CNV Loss21882294
    nsv883122CNV Gain21882294
    nsv10776CNV Gain18304495
    esv34563CNV Gain17911159
    dgv6371n71CNV Gain21882294
    dgv1876e1CNV Complex17122850

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 606929    OMIM disorders: --

    3 diseases for THOC3:    About MalaCards
    kaposi's sarcoma    sarcoma    breast cancer


    THOC3 for disorders           About GeneDecksing


    Export disorders for THOC3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for THOC3 gene, integrated from 9 sources (see all 25):
    (articles sorted by number of sources associating them with THOC3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. TREX is a conserved complex coupling transcription with messenger RNA export. (PubMed id 11979277)1, 2, 3 Straesser K....Hurt E. (2002)
    2. Recruitment of the complete hTREX complex is required for Kaposi's sarcoma-associated herpesvirus intronless mRNA nuclear export and virus replication. (PubMed id 18974867)1, 2 Boyne J.R.... Whitehouse A. (2008)
    3. Human mRNA export machinery recruited to the 5' end of mRNA. (PubMed id 17190602)1, 2 Cheng H.... Reed R. (2006)
    4. Recruitment of the human TREX complex to mRNA during splicing. (PubMed id 15998806)1, 2 Masuda S.... Reed R. (2005)
    5. Linking transcriptional elongation and messenger RNA export to metastatic breast cancers. (PubMed id 15833825)1, 2 Guo S.... Shiekhattar R. (2005)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. Aly and THO are required for assembly of the human TRE X complex and association of TREX components with the spliced mRNA. (PubMed id 23222130)1 Chi B....Cheng H. (2013)
    8. Interlaboratory reproducibility of large-scale human p rotein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (2013)
    9. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    10. mRNA export and the TREX complex. (PubMed id 22178508)1 Katahira J. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 84321 HGNC: 19072 AceView: THOC3 Ensembl:ENSG00000051596 euGenes: HUgn84321
    ECgene: THOC3 Kegg: 84321 H-InvDB: THOC3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for THOC3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for THOC3 gene:
    Search GeneIP for patents involving THOC3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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