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Aliases for THOC3 Gene

Aliases for THOC3 Gene

  • THO Complex 3 2 3 5
  • TEX1 Homolog 3 4
  • HTREX45 3 4
  • THO3 3 4
  • THO Complex Subunit 3 3

External Ids for THOC3 Gene

Previous GeneCards Identifiers for THOC3 Gene

  • GC05M176207
  • GC05M175280
  • GC05M175367
  • GC05M175319
  • GC05M175344
  • GC05P172063

Summaries for THOC3 Gene

Entrez Gene Summary for THOC3 Gene

  • This gene encodes a component of the nuclear THO transcription elongation complex, which is part of the larger transcription export (TREX) complex that couples messenger RNA processing and export. In humans, the transcription export complex is recruited to the 5'-end of messenger RNAs in a splicing- and cap-dependent manner. Studies of a related complex in mouse suggest that the metazoan transcription export complex is involved in cell differentiation and development. A pseudogene of this gene has been defined on chromosome 5. [provided by RefSeq, May 2013]

GeneCards Summary for THOC3 Gene

THOC3 (THO Complex 3) is a Protein Coding gene. Among its related pathways are RNA Polymerase II Transcription Termination and Gene Expression. Gene Ontology (GO) annotations related to this gene include RNA binding.

UniProtKB/Swiss-Prot for THOC3 Gene

  • Required for efficient export of polyadenylated RNA and spliced mRNA. Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5 end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essential for the export of Kaposis sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production.

Additional gene information for THOC3 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for THOC3 Gene

Genomics for THOC3 Gene

GeneHancer (GH) Regulatory Elements for THOC3 Gene

Promoters and enhancers for THOC3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05I175967 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 550.2 +66.6 66579 1.4 HDGF PKNOX1 ATF1 SIN3A ZNF2 ZBTB7B POLR2B ELK1 ZNF143 ATF7 THOC3 LOC105377745 ENSG00000250820
GH05I176033 Enhancer 0.4 dbSUPER 550.8 -0.6 -643 3.2 ZBTB6 ZNF512 ZBTB33 THOC3 FAM153B HRH2 LOC105377746 LOC105377747 GC05M176032
GH05I176032 Enhancer 0.2 dbSUPER 550.8 +1.4 1409 0.9 LOC105377746 THOC3 GC05M176032
GH05I176529 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 6.6 -499.6 -499619 10.3 HDGF PKNOX1 SMAD1 FOXA2 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 RNF44 GC05P176534 ENSG00000250909 NSD1 ENSG00000251414 FAF2 RPL21P60 ZNF346-IT1 UIMC1 CDHR2
GH05I175919 Enhancer 0.8 Ensembl ENCODE 7 +113.0 112997 3.8 ZNF362 RXRA MAX REST YY1 ZNF148 SP1 JUND GATA3 POLR2A THOC3 GC05P175930 ENSG00000280068 ENSG00000250820
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around THOC3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the THOC3 gene promoter:

Genomic Locations for THOC3 Gene

Genomic Locations for THOC3 Gene
chr5:175,917,873-176,034,680
(GRCh38/hg38)
Size:
116,808 bases
Orientation:
Minus strand
chr5:175,344,876-175,461,683
(GRCh37/hg19)

Genomic View for THOC3 Gene

Genes around THOC3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
THOC3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for THOC3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for THOC3 Gene

Proteins for THOC3 Gene

  • Protein details for THOC3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96J01-THOC3_HUMAN
    Recommended name:
    THO complex subunit 3
    Protein Accession:
    Q96J01
    Secondary Accessions:
    • Q6NZ53

    Protein attributes for THOC3 Gene

    Size:
    351 amino acids
    Molecular mass:
    38772 Da
    Quaternary structure:
    • Component of the THO complex, which is composed of THOC1, THOC2, THOC3, THOC5, THOC6 and THOC7; together with at least ALYREF/THOC4, DDX39B, SARNP/CIP29 and CHTOP, THO forms the transcription/export (TREX) complex which seems to have a dynamic structure involving ATP-dependent remodeling.

    Alternative splice isoforms for THOC3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for THOC3 Gene

Post-translational modifications for THOC3 Gene

  • Ubiquitination at isoforms=277, isoforms=286, isoforms=2171, and isoforms=1343

No data available for DME Specific Peptides for THOC3 Gene

Domains & Families for THOC3 Gene

Gene Families for THOC3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for THOC3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with THOC3: view

No data available for UniProtKB/Swiss-Prot for THOC3 Gene

Function for THOC3 Gene

Molecular function for THOC3 Gene

UniProtKB/Swiss-Prot Function:
Required for efficient export of polyadenylated RNA and spliced mRNA. Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5 end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essential for the export of Kaposis sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production.

Phenotypes From GWAS Catalog for THOC3 Gene

Gene Ontology (GO) - Molecular Function for THOC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IEA --
genes like me logo Genes that share ontologies with THOC3: view
genes like me logo Genes that share phenotypes with THOC3: view

Animal Model Products

CRISPR Products

miRNA for THOC3 Gene

miRTarBase miRNAs that target THOC3

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for THOC3

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for THOC3 Gene

Localization for THOC3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for THOC3 Gene

Nucleus. Nucleus speckle.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for THOC3 gene
Compartment Confidence
nucleus 5
extracellular 2
golgi apparatus 2
plasma membrane 1
peroxisome 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for THOC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000346 transcription export complex IDA 15833825
GO:0000445 THO complex part of transcription export complex IDA 23222130
GO:0000784 colocalizes_with nuclear chromosome, telomeric region IDA 24270157
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS --
genes like me logo Genes that share ontologies with THOC3: view

Pathways & Interactions for THOC3 Gene

genes like me logo Genes that share pathways with THOC3: view

Gene Ontology (GO) - Biological Process for THOC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006369 termination of RNA polymerase II transcription TAS --
GO:0006397 mRNA processing IEA --
GO:0006405 RNA export from nucleus TAS --
GO:0006406 mRNA export from nucleus TAS --
GO:0006810 transport IEA --
genes like me logo Genes that share ontologies with THOC3: view

No data available for SIGNOR curated interactions for THOC3 Gene

Drugs & Compounds for THOC3 Gene

No Compound Related Data Available

Transcripts for THOC3 Gene

Unigene Clusters for THOC3 Gene

THO complex 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for THOC3

Alternative Splicing Database (ASD) splice patterns (SP) for THOC3 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6a · 6b · 6c ^ 7a · 7b
SP1: - - - -
SP2: - -
SP3: -
SP4: - -
SP5: - - -
SP6: -

Relevant External Links for THOC3 Gene

GeneLoc Exon Structure for
THOC3
ECgene alternative splicing isoforms for
THOC3

Expression for THOC3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for THOC3 Gene

mRNA differential expression in normal tissues according to GTEx for THOC3 Gene

This gene is overexpressed in Esophagus - Mucosa (x4.1).

Protein differential expression in normal tissues from HIPED for THOC3 Gene

This gene is overexpressed in Breast (20.9) and Urine (14.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for THOC3 Gene



Protein tissue co-expression partners for THOC3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of THOC3 Gene:

THOC3

SOURCE GeneReport for Unigene cluster for THOC3 Gene:

Hs.484227

Evidence on tissue expression from TISSUES for THOC3 Gene

  • Nervous system(4.5)
genes like me logo Genes that share expression patterns with THOC3: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for THOC3 Gene

Orthologs for THOC3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for THOC3 Gene

Organism Taxonomy Gene Similarity Type Details
platypus
(Ornithorhynchus anatinus)
Mammalia THOC3 34
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia THOC3 33 34
  • 99.72 (n)
oppossum
(Monodelphis domestica)
Mammalia THOC3 34
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia THOC3 33 34
  • 92.78 (n)
cow
(Bos Taurus)
Mammalia THOC3 33 34
  • 92.4 (n)
mouse
(Mus musculus)
Mammalia Thoc3 33 16 34
  • 89.08 (n)
rat
(Rattus norvegicus)
Mammalia Thoc3 33
  • 88.7 (n)
chicken
(Gallus gallus)
Aves THOC3 33 34
  • 83.75 (n)
lizard
(Anolis carolinensis)
Reptilia THOC3 34
  • 94 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia thoc3 33
  • 80.38 (n)
Str.1963 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.22312 33
zebrafish
(Danio rerio)
Actinopterygii thoc3 33 34
  • 79.79 (n)
Dr.13333 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9463 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003891 33
  • 64.4 (n)
fruit fly
(Drosophila melanogaster)
Insecta tex 33 34
  • 64.29 (n)
worm
(Caenorhabditis elegans)
Secernentea thoc-3 34
  • 33 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SIF2 34
  • 10 (a)
OneToMany
TEX1 36
thale cress
(Arabidopsis thaliana)
eudicotyledons TEX1 33
  • 55.93 (n)
soybean
(Glycine max)
eudicotyledons Gma.12953 33
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.5046 33
rice
(Oryza sativa)
Liliopsida Os09g0298400 33
  • 55.07 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2882 34
  • 66 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.1853 33
Species where no ortholog for THOC3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for THOC3 Gene

ENSEMBL:
Gene Tree for THOC3 (if available)
TreeFam:
Gene Tree for THOC3 (if available)

Paralogs for THOC3 Gene

(3) SIMAP similar genes for THOC3 Gene using alignment to 9 proteins:

genes like me logo Genes that share paralogs with THOC3: view

No data available for Paralogs for THOC3 Gene

Variants for THOC3 Gene

Sequence variations from dbSNP and Humsavar for THOC3 Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
rs1000018214 -- 175,984,297(-) G/A genic_upstream_transcript_variant, intron_variant
rs1000387228 -- 176,012,561(-) G/C genic_upstream_transcript_variant, intron_variant
rs1000441356 -- 175,984,817(-) T/C genic_upstream_transcript_variant, intron_variant
rs1000885238 -- 176,013,139(-) A/G genic_upstream_transcript_variant, intron_variant
rs1001122606 -- 176,008,638(-) C/T genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for THOC3 Gene

Variant ID Type Subtype PubMed ID
dgv5832n100 CNV gain 25217958
dgv5833n100 CNV gain 25217958
esv2759395 CNV gain 17122850
esv34563 CNV gain 17911159
esv3575900 CNV gain 25503493
nsv1022071 CNV gain 25217958
nsv10776 CNV gain 18304495
nsv1146319 CNV duplication 26484159

Variation tolerance for THOC3 Gene

Residual Variation Intolerance Score: 67.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.37; 63.42% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for THOC3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
THOC3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for THOC3 Gene

Disorders for THOC3 Gene

Additional Disease Information for THOC3

No disorders were found for THOC3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for THOC3 Gene

Publications for THOC3 Gene

  1. Recruitment of the human TREX complex to mRNA during splicing. (PMID: 15998806) Masuda S … Reed R (Genes & development 2005) 2 3 4 58
  2. TREX is a conserved complex coupling transcription with messenger RNA export. (PMID: 11979277) Strässer K … Hurt E (Nature 2002) 2 3 4 58
  3. Aly and THO are required for assembly of the human TREX complex and association of TREX components with the spliced mRNA. (PMID: 23222130) Chi B … Cheng H (Nucleic acids research 2013) 3 4 58
  4. Recruitment of the complete hTREX complex is required for Kaposi's sarcoma-associated herpesvirus intronless mRNA nuclear export and virus replication. (PMID: 18974867) Boyne JR … Whitehouse A (PLoS pathogens 2008) 3 4 58
  5. Human mRNA export machinery recruited to the 5' end of mRNA. (PMID: 17190602) Cheng H … Reed R (Cell 2006) 3 4 58

Products for THOC3 Gene

  • Addgene plasmids for THOC3

Sources for THOC3 Gene

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