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THOC3 Gene

protein-coding   GIFtS: 51
GCID: GC05M175344

THO Complex 3

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
THO Complex 31 2     THO Complex Subunit 32
hTREX452 3     Tho33
TEX1 Homolog2 3     TEX15
THO32     

External Ids:    HGNC: 190721   Entrez Gene: 843212   Ensembl: ENSG000000515967   OMIM: 6069295   UniProtKB: Q96J013   

Export aliases for THOC3 gene to outside databases

Previous GC identifers: GC05M176207 GC05M175280 GC05M175367 GC05M175319 GC05P172063


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for THOC3 Gene:
This gene encodes a component of the nuclear THO transcription elongation complex, which is part of the larger
transcription export (TREX) complex that couples messenger RNA processing and export. In humans, the
transcription export complex is recruited to the 5'-end of messenger RNAs in a splicing- and cap-dependent
manner. Studies of a related complex in mouse suggest that the metazoan transcription export complex is involved
in cell differentiation and development. A pseudogene of this gene has been defined on chromosome 5. (provided by
RefSeq, May 2013)

GeneCards Summary for THOC3 Gene:
THOC3 (THO complex 3) is a protein-coding gene. GO annotations related to this gene include RNA binding. An important paralog of this gene is TBL1Y.

UniProtKB/Swiss-Prot: THOC3_HUMAN, Q96J01
Function: Required for efficient export of polyadenylated RNA and spliced mRNA. Acts as component of the THO
subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and
which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced
mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is
recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in
mRNA export to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essential for the export of Kaposi's
sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000005.9  NC_018916.2  NT_023133.14  
Regulatory elements:
   Regulatory transcription factor binding sites in the THOC3 gene promoter:
         RP58   Pax-5   Pbx1a   c-Ets-1   E47   RORalpha1   NRF-2   ARP-1   Sox9   Hand1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for THOC3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat THOC3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q35.2   Ensembl cytogenetic band:  5q35.2   HGNC cytogenetic band: 5q35.3

THOC3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
THOC3 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M175344:  view genomic region     (about GC identifiers)

Start:
175,344,876 bp from pter      End:
175,461,683 bp from pter
Size:
116,808 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: THOC3_HUMAN, Q96J01 (See protein sequence)
Recommended Name: THO complex subunit 3  
Size: 351 amino acids; 38772 Da
Subunit: Component of the THO complex, which is composed of THOC1, THOC2, THOC3, THOC5, THOC6 and THOC7; together
with at least ALYREF/THOC4, DDX39B, SARNP/CIP29 and CHTOP, THO forms the transcription/export (TREX) complex
which seems to have a dynamic structure involving ATP-dependent remodeling
Caution: There are two almost identical copies of this gene on chromosome 5q35. One copy is frameshifted and
unlikely to encode a functional protein

Explore the universe of human proteins at neXtProt for THOC3: NX_Q96J01

Explore proteomics data for THOC3 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys77, Lys86, Lys171, Lys343
  • Modification sites at PhosphoSitePlus

  • See THOC3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_115737.1  
    ENSEMBL proteins: 
     ENSP00000394166   ENSP00000425781   ENSP00000265097   ENSP00000424967   ENSP00000425039  
     ENSP00000422243   ENSP00000427029   ENSP00000421082   ENSP00000427267  

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    Novus Biologicals THOC3 Proteins
    Novus Biologicals THOC3 Lysates
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    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for THOC3 

     
    antibodies-online proteins for THOC3 (6 products) 

     
    antibodies-online peptides for THOC3

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    antibodies-online antibodies for THOC3 (18 products) 

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    WDR: WD repeat domain containing
    THOC: THO complex subunits

    5 InterPro protein domains:
     IPR001680 WD40_repeat
     IPR020472 G-protein_beta_WD-40_rep
     IPR011659 PD40
     IPR017986 WD40_repeat_dom
     IPR015943 WD40/YVTN_repeat-like_dom

    Graphical View of Domain Structure for InterPro Entry Q96J01

    ProtoNet protein and cluster: Q96J01

    UniProtKB/Swiss-Prot: THOC3_HUMAN, Q96J01
    Similarity: Contains 6 WD repeats


    Find genes that share domains with THOC3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: THOC3_HUMAN, Q96J01
    Function: Required for efficient export of polyadenylated RNA and spliced mRNA. Acts as component of the THO
    subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and
    which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced
    mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is
    recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in
    mRNA export to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essential for the export of Kaposi's
    sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003723RNA binding IEA--
    GO:0005515protein binding ----
         
    Find genes that share ontologies with THOC3           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for THOC3:
     Decreased viability of wild-ty  Increased S DNA content 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for THOC3

    miRNA
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    miRTarBase miRNAs that target THOC3:
    hsa-mir-27b-3p (MIRT046211), hsa-mir-181b-5p (MIRT047243), hsa-mir-27a-3p (MIRT050030)

    Block miRNA regulation of human, mouse, rat THOC3 using miScript Target Protectors
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    THOC3_HUMAN, Q96J01: Nucleus (Probable). Nucleus speckle (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    golgi apparatus3
    extracellular2
    cytosol1
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000346transcription export complex IDA15833825
    GO:0000445THO complex part of transcription export complex IDA--
    GO:0016607nuclear speck IEA--

    Find genes that share ontologies with THOC3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for THOC3 About    
    See pathways by source

    SuperPathContained pathways About
    1Spliceosome
    Spliceosome
    2RNA transport
    RNA transport


    Find genes that share SuperPaths with THOC3           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    2 Kegg Pathways  (Kegg details for THOC3):
        RNA transport
    Spliceosome

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for THOC3
    Interactions:

        Search GeneGlobe Interaction Network for THOC3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for THOC3 (Q96J012, 3 ENSP000002650974) via UniProtKB, MINT, STRING, and/or I2D (see all 39)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TK1P041832, 3MINT-8274181 I2D: score=2 
    YOD1Q5VVQ63, ENSP000003268134I2D: score=2 STRING: ENSP00000326813
    ALYREFENSP000003318174STRING: ENSP00000331817
    UBCENSP000003448184STRING: ENSP00000344818
    THOC2ENSP000002458384STRING: ENSP00000245838
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006397mRNA processing IEA--
    GO:0006406mRNA export from nucleus IDA17190602
    GO:0008380RNA splicing IEA--
    GO:0046784viral mRNA export from host cell nucleus IDA18974867

    Find genes that share ontologies with THOC3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for THOC3



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for THOC3 gene: 
    NM_032361.3  

    Unigene Cluster for THOC3:

    THO complex 3
    Hs.484227  [show with all ESTs]
    Unigene Representative Sequence: NM_032361
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000432305 ENST00000515016 ENST00000265097(uc003mdg.4) ENST00000505969
    ENST00000514861 ENST00000513482(uc003mdh.3) ENST00000510300 ENST00000511062
    ENST00000513118 ENST00000513006 ENST00000514250
    miRNA
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    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat THOC3
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      QuantiTect SYBR Green Assays in human, mouse, rat THOC3
      QuantiFast Probe-based Assays in human, mouse, rat THOC3

    Additional mRNA sequence: 

    BC006849.1 BC066325.1 BC068499.1 

    15 DOTS entries:

    DT.448496  DT.100876911  DT.101977844  DT.102825306  DT.100876909  DT.100759679  DT.100876914  DT.120866698 
    DT.120866744  DT.91674961  DT.95369043  DT.95369048  DT.100031121  DT.120863596  DT.120866741 

    Selected AceView cDNA sequences (see all 457):

    CR606947 BE792560 BI522413 BU741834 BM785154 BQ069001 BQ929394 CR601880 
    BQ059439 CR610202 BU538057 BM667103 BQ083333 BM758111 CR622623 BG764315 
    BE614101 CR602551 BM452096 BI767873 BE727794 BM729309 BX387182 AW157540 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for THOC3 (see all 6)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6a · 6b · 6c ^ 7a · 7b
    SP1:              -                       -                             -     -               
    SP2:              -                       -                                                   
    SP3:                                      -                                                   
    SP4:                                      -                                   -               
    SP5:              -     -                 -                                                   


    ECgene alternative splicing isoforms for THOC3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    THOC3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAAGTTTTTT
    THOC3 Expression
    About this image

    THOC3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    THOC3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.484227
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for THOC3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for THOC3 gene from Selected species (see all 23)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Thoc31 , 5 THO complex 31, 5 89.08(n)1
    98.86(a)1
      13 (28.69 cM)5
    736661  NM_028597.31  NP_082873.21 
     544588375 
    chicken
    (Gallus gallus)
    Aves THOC31 THO complex 3 83.75(n)
    94.37(a)
      416232  NM_001030611.1  NP_001025782.1 
    lizard
    (Anolis carolinensis)
    Reptilia THOC36
    THO complex 3
    94(a)
    1 ↔ 1
    GL343548.1(410674-419279)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.223122 Xenopus laevis transcribed sequence with moderate similarity more 82.23(n)    CA974741.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.133332 Transcribed sequence with strong similarity to protein more 80.47(n)    57047699 
    fruit fly
    (Drosophila melanogaster)
    Insecta tex1 tex 64.29(n)
    63.96(a)
      40983  NM_141527.2  NP_649784.1 
    worm
    (Caenorhabditis elegans)
    Secernentea thoc-36
    Protein THOC-3 (thoc-3) mRNA, complete cds
    33(a)
    1 ↔ 1
    I(8971137-8973042) WBGene00009341
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes TEX1(YNL253W)4 Protein involved in mRNA export, component of the transcription more   --   14(170018-171286) 855468  NP_014146.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons TEX11 TEX1 55.93(n)
    50(a)
      835712  NM_124995.4  NP_200424.1 
    rice
    (Oryza sativa)
    Liliopsida Os09g02984001 Os09g0298400 55.07(n)
    48.99(a)
      4346657  NM_001069344.1  NP_001062809.1 


    ENSEMBL Gene Tree for THOC3 (if available)
    TreeFam Gene Tree for THOC3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for THOC3 gene
    TBL1Y2  TBL1XR12  TBL1X2  
    3 SIMAP similar genes for THOC3 using alignment to 9 protein entries:     THOC3_HUMAN (see all proteins):
    RBBP4    POC1B    KATNB1

    Find genes that share paralogs with THOC3           About GenesLikeMe


    2 Pseudogenes.org Pseudogenes for THOC3
    PGOHUM00000251399 PGOHUM00000251400


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for THOC3 (see all 137)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1901779701,2
    --175386277(+) TTTCCA/TTGAGG 1 -- int10--------
    rs1396376521,2
    --175386320(+) GCTAAA/CTGACT 1 -- int10--------
    rs1148763701,2
    F--175386362(+) TCAGAG/ACCAAA 1 -- int11Minor allele frequency- A:0.02WA 118
    rs556615321,2
    C,F--175386586(+) TATATG/ATATAT 1 -- ut312Minor allele frequency- A:0.14WA NA 238
    rs3703335001,2
    C--175386734(+) GTATGC/GGGGGT 1 -- ut310--------
    rs1452056251,2
    --175386765(+) TCCACA/GCGAGT 1 -- ut310--------
    rs1476377421,2
    C--175386828(+) AAGAAC/TGAAAT 1 -- ut310--------
    rs2012190881,2
    C,F--175387011(+) GTTCCG/AGCTTC 2 /A syn11Minor allele frequency- A:0.00EU 1229
    rs797203331,2
    C,F--175387139(+) CCCTAT/CAGAAA 1 -- int12Minor allele frequency- C:0.13NA EU 1053
    rs1422718211,2
    C--175387206(+) TTACCA/TGTATT 1 -- int10--------

    HapMap Linkage Disequilibrium report for THOC3 (175344876 - 175461683 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for THOC3:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv883125CNV Loss21882294
    nsv883122CNV Gain21882294
    nsv10776CNV Gain18304495
    esv34563CNV Gain17911159
    dgv6371n71CNV Gain21882294
    dgv1876e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 606929    OMIM disorders: --


    Find genes that share disorders with THOC3           About GenesLikeMe


    Export disorders for THOC3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for THOC3 gene, integrated from 10 sources (see all 27):
    (articles sorted by number of sources associating them with THOC3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. TREX is a conserved complex coupling transcription with messenger RNA export. (PubMed id 11979277)1, 2, 3 Straesser K....Hurt E. (Nature 2002)
    2. Aly and THO are required for assembly of the human TREX complex and association of TREX components with the spliced mRNA. (PubMed id 23222130)1, 2 Chi B....Cheng H. (Nucleic Acids Res. 2013)
    3. Recruitment of the complete hTREX complex is required for Kaposi's sarcoma-associated herpesvirus intronless mRNA nuclear export and virus replication. (PubMed id 18974867)1, 2 Boyne J.R.... Whitehouse A. (PLoS Pathog. 2008)
    4. Human mRNA export machinery recruited to the 5' end of mRNA. (PubMed id 17190602)1, 2 Cheng H.... Reed R. (Cell 2006)
    5. Recruitment of the human TREX complex to mRNA during splicing. (PubMed id 15998806)1, 2 Masuda S.... Reed R. (Genes Dev. 2005)
    6. Linking transcriptional elongation and messenger RNA export to metastatic breast cancers. (PubMed id 15833825)1, 2 Guo S.... Shiekhattar R. (Cancer Res. 2005)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (Nat. Methods 2013)
    9. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    10. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 84321 HGNC: 19072 AceView: THOC3 Ensembl:ENSG00000051596 euGenes: HUgn84321
    ECgene: THOC3 Kegg: 84321 H-InvDB: THOC3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for THOC3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for THOC3 gene:
    Search GeneIP for patents involving THOC3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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