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Aliases for THOC2 Gene

Aliases for THOC2 Gene

  • THO Complex 2 2 3
  • THO2 3 4 6
  • HTREX120 3 4
  • CXorf3 3 4
  • Chromosome X Open Reading Frame 3 2
  • THO Complex Subunit 2 3
  • DJ506G2.1 3

External Ids for THOC2 Gene

Previous HGNC Symbols for THOC2 Gene

  • CXorf3

Previous GeneCards Identifiers for THOC2 Gene

  • GC0XM119627
  • GC0XM120686
  • GC0XM121432
  • GC0XM122461
  • GC0XM122571
  • GC0XM122734
  • GC0XM112121

Summaries for THOC2 Gene

Entrez Gene Summary for THOC2 Gene

  • The TREX multiprotein complex binds specifically to spliced mRNAs to facilitate mRNA export. The protein encoded by this gene is a member of the THO complex, a subset of the TREX complex. The encoded protein interacts with the THOC1 protein.[provided by RefSeq, Jun 2010]

GeneCards Summary for THOC2 Gene

THOC2 (THO Complex 2) is a Protein Coding gene. Among its related pathways are RNA transport and Spliceosome. GO annotations related to this gene include RNA binding.

UniProtKB/Swiss-Prot for THOC2 Gene

  • Required for efficient export of polyadenylated RNA and spliced mRNA. Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5 end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essential for the export of Kaposis sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. THOC2 (and probably the THO complex) is involved in releasing mRNA from nuclear speckle domains. Required for NXF1 localization to the nuclear rim.

Gene Wiki entry for THOC2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for THOC2 Gene

Genomics for THOC2 Gene

Regulatory Elements for THOC2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for THOC2 Gene

Start:
123,600,561 bp from pter
End:
123,733,056 bp from pter
Size:
132,496 bases
Orientation:
Minus strand

Genomic View for THOC2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for THOC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for THOC2 Gene

Proteins for THOC2 Gene

  • Protein details for THOC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NI27-THOC2_HUMAN
    Recommended name:
    THO complex subunit 2
    Protein Accession:
    Q8NI27
    Secondary Accessions:
    • A6NM50
    • Q5JZ12
    • Q6IN92
    • Q9H8I6

    Protein attributes for THOC2 Gene

    Size:
    1593 amino acids
    Molecular mass:
    182775 Da
    Quaternary structure:
    • Component of the THO complex, which is composed of THOC1, THOC2, THOC3, THOC5, THOC6 and THOC7; together with at least ALYREF/THOC4, DDX39B, SARNP/CIP29 and CHTOP, THO forms the transcription/export (TREX) complex which seems to have a dynamic structure involving ATP-dependent remodeling. Interacts with THOC1, POLDIP3 and ZC3H11A.
    SequenceCaution:
    • Sequence=AAM28436.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the N-terminal part.; Evidence={ECO:0000305}; Sequence=BAB14630.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for THOC2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for THOC2 Gene

Proteomics data for THOC2 Gene at MOPED

Post-translational modifications for THOC2 Gene

  • Ubiquitination at Lys345, Lys730, and Lys1084
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for THOC2 Gene

Domains for THOC2 Gene

Gene Families for THOC2 Gene

HGNC:
  • THOC :THO complex subunits

Protein Domains for THOC2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for THOC2 Gene

Graphical View of Domain Structure for InterPro Entry

Q8NI27

UniProtKB/Swiss-Prot:

THOC2_HUMAN :
  • Q8NI27
Family:
  • Belongs to the THOC2 family.
genes like me logo Genes that share domains with THOC2: view

Function for THOC2 Gene

Molecular function for THOC2 Gene

UniProtKB/Swiss-Prot Function: Required for efficient export of polyadenylated RNA and spliced mRNA. Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5 end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essential for the export of Kaposis sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. THOC2 (and probably the THO complex) is involved in releasing mRNA from nuclear speckle domains. Required for NXF1 localization to the nuclear rim.

Gene Ontology (GO) - Molecular Function for THOC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IEA --
GO:0005515 protein binding IPI 15870275
genes like me logo Genes that share ontologies with THOC2: view
genes like me logo Genes that share phenotypes with THOC2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for THOC2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for THOC2 Gene

Localization for THOC2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for THOC2 Gene

Nucleus. Nucleus speckle.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for THOC2 Gene COMPARTMENTS Subcellular localization image for THOC2 gene
Compartment Confidence
nucleus 5
cytosol 1
endoplasmic reticulum 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for THOC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000346 transcription export complex IDA 15833825
GO:0000347 THO complex IDA 15998806
GO:0000445 THO complex part of transcription export complex IDA 15998806
GO:0005654 nucleoplasm IDA --
GO:0016607 nuclear speck IEA --
genes like me logo Genes that share ontologies with THOC2: view

Pathways for THOC2 Gene

SuperPathways for THOC2 Gene

Superpath Contained pathways
1 RNA transport
2 Spliceosome
genes like me logo Genes that share pathways with THOC2: view

Pathways by source for THOC2 Gene

2 KEGG pathways for THOC2 Gene

Gene Ontology (GO) - Biological Process for THOC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006397 mRNA processing IEA --
GO:0006406 mRNA export from nucleus IDA 17190602
GO:0008380 RNA splicing IEA --
GO:0016973 poly(A)+ mRNA export from nucleus IDA 22928037
GO:0046784 viral mRNA export from host cell nucleus IDA 18974867
genes like me logo Genes that share ontologies with THOC2: view

Transcripts for THOC2 Gene

Unigene Clusters for THOC2 Gene

THO complex 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for THOC2

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for THOC2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for THOC2 Gene

No ASD Table

Relevant External Links for THOC2 Gene

GeneLoc Exon Structure for
THOC2
ECgene alternative splicing isoforms for
THOC2

Expression for THOC2 Gene

mRNA expression in normal human tissues for THOC2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for THOC2 Gene

SOURCE GeneReport for Unigene cluster for THOC2 Gene Hs.149991

genes like me logo Genes that share expressions with THOC2: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for THOC2 Gene

Orthologs for THOC2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for THOC2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia THOC2 35
  • 99.81 (n)
  • 99.94 (a)
THOC2 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 96 (a)
OneToMany
-- 36
  • 98 (a)
OneToMany
THOC2 35
  • 95.92 (n)
  • 98.81 (a)
dog
(Canis familiaris)
Mammalia THOC2 35
  • 96.67 (n)
  • 99 (a)
THOC2 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Thoc2 35
  • 93.2 (n)
  • 97.47 (a)
Thoc2 16
Thoc2 36
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia THOC2 36
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia THOC2 36
  • 87 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Thoc2 35
  • 93.24 (n)
  • 97.6 (a)
chicken
(Gallus gallus)
Aves THOC2 35
  • 81.41 (n)
  • 86.96 (a)
THOC2 36
  • 86 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia THOC2 36
  • 84 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.21353 35
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.17127 35
thoc2 35
  • 76.05 (n)
  • 80.89 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9743 35
zebrafish
(Danio rerio)
Actinopterygii thoc2 35
  • 70.46 (n)
  • 76.55 (a)
thoc2 36
  • 76 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008236 35
  • 53.89 (n)
  • 53.27 (a)
fruit fly
(Drosophila melanogaster)
Insecta tho2 35
  • 52.83 (n)
  • 49.19 (a)
tho2 36
  • 40 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea thoc-2 35
  • 49.23 (n)
  • 38.1 (a)
thoc-2 36
  • 33 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes THO2 36
  • 20 (a)
OneToOne
THO2 38
thale cress
(Arabidopsis thaliana)
eudicotyledons THO2 35
  • 47.71 (n)
  • 38.57 (a)
rice
(Oryza sativa)
Liliopsida Os01g0916800 35
  • 50.29 (n)
  • 40.45 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.10097 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 38 (a)
OneToMany
CSA.3583 36
  • 60 (a)
OneToMany
Species with no ortholog for THOC2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for THOC2 Gene

ENSEMBL:
Gene Tree for THOC2 (if available)
TreeFam:
Gene Tree for THOC2 (if available)

Paralogs for THOC2 Gene

No data available for Paralogs for THOC2 Gene

Variants for THOC2 Gene

Sequence variations from dbSNP and Humsavar for THOC2 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs16296 -- 123,713,411(+) cagag(C/G)ttgca intron-variant
rs218730 -- 123,734,302(-) cagac(A/G)gggtg upstream-variant-2KB
rs218731 -- 123,734,186(-) ccaga(C/T)ggggc upstream-variant-2KB
rs415361 -- 123,734,411(+) ggggc(A/G)cctct upstream-variant-2KB
rs695215 -- 123,666,287(+) CATTT(C/T)TCAAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for THOC2 Gene

Variant ID Type Subtype PubMed ID
nsv7069 CNV Insertion 18451855

Relevant External Links for THOC2 Gene

HapMap Linkage Disequilibrium report
THOC2
Human Gene Mutation Database (HGMD)
THOC2
Locus Specific Mutation Databases (LSDB)
THOC2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for THOC2 Gene

Disorders for THOC2 Gene

Relevant External Links for THOC2

Genetic Association Database (GAD)
THOC2
Human Genome Epidemiology (HuGE) Navigator
THOC2
genes like me logo Genes that share disorders with THOC2: view

No data available for UniProtKB/Swiss-Prot for THOC2 Gene

Publications for THOC2 Gene

  1. TREX is a conserved complex coupling transcription with messenger RNA export. (PMID: 11979277) Straesser K. … Hurt E. (Nature 2002) 2 3 4
  2. Recruitment of the human TREX complex to mRNA during splicing. (PMID: 15998806) Masuda S. … Reed R. (Genes Dev. 2005) 2 3 4
  3. Linking transcriptional elongation and messenger RNA export to metastatic breast cancers. (PMID: 15833825) Guo S. … Shiekhattar R. (Cancer Res. 2005) 3 4
  4. Human hHpr1/p84/Thoc1 regulates transcriptional elongation and physically links RNA polymerase II and RNA processing factors. (PMID: 15870275) Li Y. … Goodrich D.W. (Mol. Cell. Biol. 2005) 3 4
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4

Products for THOC2 Gene

Sources for THOC2 Gene

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