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THOC2 Gene

protein-coding   GIFtS: 56
GCID: GC0XM122734

THO Complex 2

(Previous name: chromosome X open reading frame 3)
(Previous symbol: CXorf3)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
THO Complex 21 2     Chromosome X Open Reading Frame 31
CXorf31 2 3     dJ506G2.12
hTREX1202 3     THO Complex Subunit 22
THO22 5     Tho23

External Ids:    HGNC: 190731   Entrez Gene: 571872   Ensembl: ENSG000001256767   OMIM: 3003955   UniProtKB: Q8NI273   

Export aliases for THOC2 gene to outside databases

Previous GC identifers: GC0XM119627 GC0XM120686 GC0XM121432 GC0XM122461 GC0XM122571 GC0XM112121


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for THOC2 Gene:
The TREX multiprotein complex binds specifically to spliced mRNAs to facilitate mRNA export. The protein encoded
by this gene is a member of the THO complex, a subset of the TREX complex. The encoded protein interacts with the
THOC1 protein.(provided by RefSeq, Jun 2010)

GeneCards Summary for THOC2 Gene:
THOC2 (THO complex 2) is a protein-coding gene. Diseases associated with THOC2 include peliosis hepatis, and typhus. GO annotations related to this gene include RNA binding.

UniProtKB/Swiss-Prot: THOC2_HUMAN, Q8NI27
Function: Required for efficient export of polyadenylated RNA and spliced mRNA. Acts as component of the THO
subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and
which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced
mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is
recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in
mRNA export to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essential for the export of Kaposi's
sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. THOC2 (and probably the
THO complex) is involved in releasing mRNA from nuclear speckle domains. Required for NXF1 localization to the
nuclear rim

Gene Wiki entry for THOC2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000023.11  NT_011786.17  NC_018934.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the THOC2 gene promoter:
         c-Fos   AP-1   AML1a   Bach2   FOXC1   POU2F1   POU2F1a   ARP-1   Cart-1   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTHOC2 promoter sequence
   Search Chromatin IP Primers for THOC2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat THOC2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq25-q26.3   Ensembl cytogenetic band:  Xq25   HGNC cytogenetic band: Xq25-q26.3

THOC2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
THOC2 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XM122734:  view genomic region     (about GC identifiers)

Start:
122,734,412 bp from pter      End:
122,866,906 bp from pter
Size:
132,495 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: THOC2_HUMAN, Q8NI27 (See protein sequence)
Recommended Name: THO complex subunit 2  
Size: 1593 amino acids; 182775 Da
Subunit: Component of the THO complex, which is composed of THOC1, THOC2, THOC3, THOC5, THOC6 and THOC7; together
with at least ALYREF/THOC4, DDX39B, SARNP/CIP29 and CHTOP, THO forms the transcription/export (TREX) complex
which seems to have a dynamic structure involving ATP-dependent remodeling. Interacts with THOC1, POLDIP3 and
ZC3H11A
Sequence caution: Sequence=AAM28436.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of
unknown origin in the N-terminal part; Sequence=BAB14630.1; Type=Erroneous initiation; Note=Translation
N-terminally extended;
Secondary accessions: A6NM50 Q5JZ12 Q6IN92 Q9H8I6
Alternative splicing: 2 isoforms:  Q8NI27-1   Q8NI27-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for THOC2: NX_Q8NI27

Explore proteomics data for THOC2 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys345, Lys730, Lys1084
  • Modification sites at PhosphoSitePlus

  • See THOC2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001075019.1  
    ENSEMBL proteins: 
     ENSP00000397317   ENSP00000415211   ENSP00000415947   ENSP00000402168   ENSP00000415244  
     ENSP00000347959   ENSP00000419795   ENSP00000416639   ENSP00000415374   ENSP00000245838  

    THOC2 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    THOC: THO complex subunits

    2 InterPro protein domains:
     IPR021418 THO_THOC2_C
     IPR021726 THO_THOC2_N

    Graphical View of Domain Structure for InterPro Entry Q8NI27

    ProtoNet protein and cluster: Q8NI27

    UniProtKB/Swiss-Prot: THOC2_HUMAN, Q8NI27
    Similarity: Belongs to the THOC2 family


    THOC2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: THOC2_HUMAN, Q8NI27
    Function: Required for efficient export of polyadenylated RNA and spliced mRNA. Acts as component of the THO
    subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and
    which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced
    mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is
    recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in
    mRNA export to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essential for the export of Kaposi's
    sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. THOC2 (and probably the
    THO complex) is involved in releasing mRNA from nuclear speckle domains. Required for NXF1 localization to the
    nuclear rim

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003723RNA binding IEA--
    GO:0005515protein binding IPI15870275
         
    THOC2 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for THOC2:
     Decreased p24 protein expressi  Increased gamma-H2AX phosphory  Upregulation of Wnt/beta-caten 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for THOC2
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    miRNA
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    miRTarBase miRNAs that target THOC2:
    hsa-mir-877-3p (MIRT036819), hsa-mir-218-5p (MIRT024250), hsa-mir-183-5p (MIRT047168), hsa-mir-1180-3p (MIRT035917), hsa-mir-34a-5p (MIRT025327), hsa-mir-21-5p (MIRT030768)

    Block miRNA regulation of human, mouse, rat THOC2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate THOC2 (see all 20):
    hsa-miR-539 hsa-miR-520d-5p hsa-let-7d hsa-miR-202 hsa-let-7c hsa-miR-218 hsa-let-7g hsa-let-7a
    SwitchGear 3'UTR luciferase reporter plasmidTHOC2 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for THOC2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    THOC2_HUMAN, Q8NI27: Nucleus (Probable). Nucleus speckle (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol1
    endoplasmic reticulum1
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000346transcription export complex IDA15833825
    GO:0000347THO complex IDA15998806
    GO:0000445THO complex part of transcription export complex IDA15998806
    GO:0016607nuclear speck IEA--

    THOC2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for THOC2 About    
    See pathways by source

    SuperPathContained pathways About
    1Spliceosome
    Spliceosome
    2RNA transport
    RNA transport

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    2 Kegg Pathways  (Kegg details for THOC2):
        RNA transport
    Spliceosome


    THOC2 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for THOC2
    Interactions:

        Search GeneGlobe Interaction Network for THOC2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for THOC2 (Q8NI272, 3 ENSP000002458384) via UniProtKB, MINT, STRING, and/or I2D (see all 693)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DDX39BQ138382, 3MINT-7945693 I2D: score=5 
    ENSG00000215425Q138382, 3MINT-7945693 I2D: score=5 
    ENSG00000225073Q138382, 3MINT-7945693 I2D: score=5 
    ENSG00000225859Q138382, 3MINT-7945693 I2D: score=5 
    ENSG00000229496Q138382, 3MINT-7945693 I2D: score=5 
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006397mRNA processing IEA--
    GO:0006406mRNA export from nucleus IDA17190602
    GO:0008380RNA splicing IEA--
    GO:0016973poly(A)+ mRNA export from nucleus IDA--
    GO:0046784viral mRNA export from host cell nucleus IDA18974867

    THOC2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for THOC2



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for THOC2 gene (2 alternative transcripts): 
    NM_001081550.1  NM_020449.2  

    Unigene Cluster for THOC2:

    THO complex 2
    Hs.149991  [show with all ESTs]
    Unigene Representative Sequence: NM_001081550
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 19):
    ENST00000448128 ENST00000441692(uc004etv.4) ENST00000492203 ENST00000497887
    ENST00000432353(uc010nqt.1) ENST00000455053 ENST00000416618 ENST00000355725(uc011muh.1 uc011mui.1)
    ENST00000491737(uc004etw.1) ENST00000464992 ENST00000496830 ENST00000464604
    ENST00000464982 ENST00000438358 ENST00000459945 ENST00000464161 ENST00000433883
    ENST00000419789
    miRNA
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    Block miRNA regulation of human, mouse, rat THOC2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate THOC2 (see all 20):
    hsa-miR-539 hsa-miR-520d-5p hsa-let-7d hsa-miR-202 hsa-let-7c hsa-miR-218 hsa-let-7g hsa-let-7a
    SwitchGear 3'UTR luciferase reporter plasmidTHOC2 3' UTR sequence
    Inhib. RNA
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    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat THOC2
      QuantiFast Probe-based Assays in human, mouse, rat THOC2

    Additional mRNA sequence: 

    AF441770.1 AK001758.1 AK023659.1 AK296780.1 AL133117.1 BC054050.1 BC063692.1 BC072400.1 
    BX648654.1 

    16 DOTS entries:

    DT.99947239  DT.103735  DT.92432224  DT.92035097  DT.100023797  DT.95369975  DT.91980883  DT.409023 
    DT.99977114  DT.40258846  DT.446754  DT.75114885  DT.422890  DT.95305519  DT.95369979  DT.97772404 

    Selected AceView cDNA sequences (see all 279):

    BU165212 AW969074 BX112985 AA485222 AA701436 AA255427 BF592955 BC054050 
    AI700491 AW589469 AK001758 AI922336 AA452963 AA479425 AI656529 BF914303 
    BX471089 AA044429 AW470913 AI339006 AI087953 AA286922 AA766899 AI679584 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    THOC2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    THOC2 Expression
    About this image


    THOC2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Blood (Hematopoietic System)
             pre Conventional Dendritic Cells Peripheral Blood
    THOC2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    THOC2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.149991
        Custom PCR Arrays for THOC2
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for THOC2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for THOC2 gene from Selected species (see all 21)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Thoc21 , 5 THO complex 21, 5 93.2(n)1
    97.47(a)1
      X (23.19 cM)5
    3314011  NM_001033422.11  NP_001028594.11 
     417949915 
    chicken
    (Gallus gallus)
    Aves THOC21 THO complex 2 81.41(n)
    86.96(a)
      422361  XM_420332.4  XP_420332.2 
    lizard
    (Anolis carolinensis)
    Reptilia THOC26
    THO complex 2
    84(a)
    1 ↔ 1
    GL343409.1(6161-44448)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.213532 Xenopus laevis transcribed sequence with weak similarity more 78.04(n)    CA788467.1 
    zebrafish
    (Danio rerio)
    Actinopterygii thoc22 THO complex 2 78.41(n)   368417  BI704311.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta tho21 tho2 52.83(n)
    49.19(a)
      326153  NM_164454.2  NP_722763.1 
    worm
    (Caenorhabditis elegans)
    Secernentea thoc-21 thoc-2 49.23(n)
    38.1(a)
      175900  NM_065991.4  NP_498392.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes THO2(YNL139C)4 Subunit of the THO complex, which is required for efficient more   --   14(365717-360924) 855583  NP_014260.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons THO21 THO2 47.71(n)
    38.57(a)
      839081  NM_102309.6  NP_173871.6 
    rice
    (Oryza sativa)
    Liliopsida Os01g09168001 Os01g0916800 50.29(n)
    40.45(a)
      4324336  NM_001051732.2  NP_001045197.2 


    ENSEMBL Gene Tree for THOC2 (if available)
    TreeFam Gene Tree for THOC2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for THOC2 (see all 2091)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1857142201,2
    C--112256586(+) TGCAGA/GAGAAT 1 -- us2k10--------
    rs736307231,2
    C,F--122687919(+) TGAATG/ATATCA 1 -- int11Minor allele frequency- A:0.00WA 2
    rs455678311,2
    C--122688050(+) AAAAAA/GTTATA 1 -- int10--------
    rs1827540221,2
    --122688099(+) GTATCA/GTTTCC 1 -- int10--------
    rs123891361,2
    F,H--122688578(+) AAACAC/TGTTTA 1 -- ut314Minor allele frequency- T:0.01NS EA 418
    rs1922141191,2
    --122688600(+) GTACTA/CTATAA 1 -- ut310--------
    rs1832266371,2
    --122688642(+) TCCCAC/GTGCTT 1 -- ut310--------
    rs1421190991,2
    --122688891(+) GCCATA/TACTGA 1 -- ut310--------
    rs1889342071,2
    --122688955(+) AACAAC/TTTTAA 1 -- ut310--------
    rs24731811,2
    C,F,O,A,H--122689131(+) ATAGAG/CAAGAA 1 -- int112Minor allele frequency- C:0.47NS EA NA WA CSA 562

    HapMap Linkage Disequilibrium report for THOC2 (122734412 - 122866906 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for THOC2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv7069CNV Insertion18451855

    Human Gene Mutation Database (HGMD): THOC2
    Locus Specific Mutation Databases (LSDB): THOC2

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 300395    OMIM disorders: --

    9 diseases for THOC2:    
    About MalaCards
    peliosis hepatis    typhus    scrub typhus    angiosarcoma
    kaposi's sarcoma    sarcoma    hiv-1    breast cancer
    malaria


    THOC2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): THOC2
    Human Genome Epidemiology (HuGE) Navigator: THOC2 (1 document)

    Export disorders for THOC2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for THOC2 gene, integrated from 10 sources (see all 41):
    (articles sorted by number of sources associating them with THOC2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. TREX is a conserved complex coupling transcription with messenger RNA export. (PubMed id 11979277)1, 2, 3 Straesser K....Hurt E. (Nature 2002)
    2. Recruitment of the complete hTREX complex is required for Kaposi's sarcoma-associated herpesvirus intronless mRNA nuclear export and virus replication. (PubMed id 18974867)1, 2 Boyne J.R.... Whitehouse A. (PLoS Pathog. 2008)
    3. Human mRNA export machinery recruited to the 5' end of mRNA. (PubMed id 17190602)1, 2 Cheng H.... Reed R. (Cell 2006)
    4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    5. Recruitment of the human TREX complex to mRNA during splicing. (PubMed id 15998806)1, 2 Masuda S.... Reed R. (Genes Dev. 2005)
    6. Human hHpr1/p84/Thoc1 regulates transcriptional elongation and physically links RNA polymerase II and RNA processing factors. (PubMed id 15870275)1, 2 Li Y.... Goodrich D.W. (Mol. Cell. Biol. 2005)
    7. Linking transcriptional elongation and messenger RNA export to metastatic breast cancers. (PubMed id 15833825)1, 2 Guo S.... Shiekhattar R. (Cancer Res. 2005)
    8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    9. Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions. (PubMed id 24255178)1 Couzens A.L....Gingras A.C. (Sci Signal 2013)
    10. Aly and THO are required for assembly of the human TREX complex and association of TREX components with the spliced mRNA. (PubMed id 23222130)2 Chi B....Cheng H. (Nucleic Acids Res. 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 57187 HGNC: 19073 AceView: THOC2 Ensembl:ENSG00000125676 euGenes: HUgn57187
    ECgene: THOC2 Kegg: 57187 H-InvDB: THOC2

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for THOC2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for THOC2 gene:
    Search GeneIP for patents involving THOC2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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