THOC1 Gene
protein-coding GIFtS: 55
GCID: GC18M000204
|
|
THO complex 1
| |
Aliases
for THOC1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| THO Complex 11 2 | | P84N52 | | HPR11 2 3 5 | | THO Complex Subunit 12 | | P841 2 | | Tho13 | | Nuclear Matrix Protein P842 3 | | Tho13 | | HTREX841 | | P84N52 |
Export aliases for THOC1 gene to outside databasesPrevious GC identifer: GC18M000202 |
Summaries
for THOC1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for THOC1:
HPR1 is part of the TREX (transcription/export) complex, which includes TEX1 (MIM 606929), THO2 (MIM 300395), ALY (MIM604171), and UAP56 (MIM 142560).(supplied by OMIM, Nov 2010)
UniProtKB/Swiss-Prot: THOC1_HUMAN, Q96FV9Function: Component of the THO subcomplex of the TREX complex. The TREX complex specifically associates with splicedmRNA and not with unspliced pre-mRNA. It is recruited to spliced mRNAs by a transcription-independent mechanism. Bindsto mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to aregion near the 5' end of the mRNA where it functions in mRNA export. The recruitment occurs via an interactionbetween ALYREF/THOC4 and the cap-binding protein NCBP1. DDX39B functions as a bridge between ALYREF/THOC4 and the THOcomplex. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronlessmRNAs and infectious virus production. The recruitment of the TREX complex to the intronless viral mRNA occurs via aninteraction between KSHV ORF57 protein and ALYREF/THOC4Function: Regulates transcriptional elongation of a subset of genes. Participates in an apoptotic pathway which ischaracterized by activation of caspase-6, increases in the expression of BAK1 and BCL2L1 and activation of NF-kappa-B.This pathway does not require p53/TP53, nor does the presence of p53/TP53 affect the efficiency of cell killing.Activates a G2/M cell cycle checkpoint prior to the onset of apoptosis. Apoptosis is inhibited by association with RB1
Gene Wiki entry for THOC1
|
Genomic Views
for THOC1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000018.9 NC_018929.1 NT_010859.14
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the THOC1 gene promoter:
p53 POU3F2 (N-Oct-5a) POU6F1 (c2) CUTL1 POU3F2 Evi-1 FOXL1 PPAR-alpha POU2F1 POU2F1a
Other transcription factors
Search SABiosciences Chromatin IP Primers for THOC1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat THOC1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 18p11.32 Ensembl cytogenetic band: 18p11.32 HGNC cytogenetic band: 18p11.32THOC1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 18 GeneLoc Exon Structure GeneLoc location for GC18M000204: view genomic region
(about GC identifiers)
Start:
|
214,520 bp from pter |
End:
|
268,059 bp from pter |
Size:
|
53,540 bases |
Orientation:
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minus strand |
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Proteins
for THOC1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: THOC1_HUMAN, Q96FV9 (See
protein sequence)Recommended Name: THO complex subunit 1 Size: 657 amino acids; 75666 Da
Subunit: Component of the THO complex, which is composed of THOC1, THOC2, THOC5, THOC6 and THOC7. Together with THOC3,ALYREF/THOC4 and DDX39B, THO forms the transcription/export (TREX) complex. Binds to the hypophosphorylated form ofRB1. Interacts with THOC2, DDX39B and RNA polymerase II
Subcellular location: Isoform 1: Nucleus speckle. Nucleus, nucleoplasm. Nucleus matrix. Cytoplasm. Note=Can shuttlebetween the nucleus and cytoplasm. Nuclear localization is required for induction of apoptotic cell death.Translocates to the cytoplasm during the early phase of apoptosis execution
Subcellular location: Isoform 2: Cytoplasm
1 PDB 3D structure from  and Proteopedia  for THOC1:1WXP (3D)
Secondary accessions: B2RBP6 Q15219 Q64I72 Q64I73Alternative splicing: 2 isoforms: Q96FV9-1 Q96FV9-2 (May be due to an intron retention)Explore the universe of human proteins at neXtProt for THOC1: NX_Q96FV9
Post-translational modifications:
Expression is altered specifically during apoptosis and is accompanied by the appearance of novel forms with smallerapparent molecular mass1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q96FV9
THOC1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_005122.2
ENSEMBL proteins: ENSP00000462757 ENSP00000261600 ENSP00000463965 ENSP00000461943
Human Recombinant Protein Products:
Gene Ontology (GO): 5/8 cellular component terms (GO ID links to tree view) (see all 8): About this table
THOC1 for ontologies About GeneDecksing
THOC1 Antibody Products:
Assay Products for THOC1: |
Protein
Domains /
Families
for THOC1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
THOC1 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q96FV9ProtoNet protein and cluster: Q96FV9 1 Blocks protein family: IPB000488 Death domain
UniProtKB/Swiss-Prot: THOC1_HUMAN, Q96FV9Domain: An intact death domain is needed for apoptosisSimilarity: Contains 1 death domain |
Function
for THOC1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: THOC1_HUMAN, Q96FV9Function: Component of the THO subcomplex of the TREX complex. The TREX complex specifically associates with splicedmRNA and not with unspliced pre-mRNA. It is recruited to spliced mRNAs by a transcription-independent mechanism. Bindsto mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to aregion near the 5' end of the mRNA where it functions in mRNA export. The recruitment occurs via an interactionbetween ALYREF/THOC4 and the cap-binding protein NCBP1. DDX39B functions as a bridge between ALYREF/THOC4 and the THOcomplex. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronlessmRNAs and infectious virus production. The recruitment of the TREX complex to the intronless viral mRNA occurs via aninteraction between KSHV ORF57 protein and ALYREF/THOC4Function: Regulates transcriptional elongation of a subset of genes. Participates in an apoptotic pathway which ischaracterized by activation of caspase-6, increases in the expression of BAK1 and BCL2L1 and activation of NF-kappa-B.This pathway does not require p53/TP53, nor does the presence of p53/TP53 affect the efficiency of cell killing.Activates a G2/M cell cycle checkpoint prior to the onset of apoptosis. Apoptosis is inhibited by association with RB1Induction: Up-regulated during cell proliferation
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for THOC1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for THOC1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: THOC1 (NM_005131) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for THOC1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat THOC1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for THOC1 |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
THOC1 for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for THOC1:
Animal Models:
Mouse knock-out Thoc1tm1Dwg for THOC1
4 MGI mutant phenotypes (inferred from 3 alleles ) (MGI details for Thoc1):
THOC1 for phenotypes About GeneDecksing
|
Pathways & Interactions
for THOC1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | RNA transport | | | 2 | mRNA Splicing - Major Pathway | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2 
Kegg Pathways (Kegg details for THOC1):
THOC1 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for THOC1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 20)
5/575 Interacting proteins for THOC1 (Q96FV92, 3 ENSP000002616004) via UniProtKB, MINT, STRING, and/or I2D (see all 575)About this table
Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9): About this table
THOC1 for ontologies About GeneDecksing
|
Drugs & Compounds
for THOC1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for THOC1
Search CenterWatch for drugs/clinical trials and news about THOC1
|
Transcripts
for THOC1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for THOC1 gene: NM_005131.2 Unigene Cluster for THOC1: THO complex 1 Hs.712543 [show with all ESTs]Unigene Representative Sequence: NM_00513118 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000579232(uc002kkl.2) ENST00000577429 ENST00000583228 ENST00000578529
ENST00000580038 ENST00000261600(uc002kkj.4) ENST00000584470(uc002kkh.4)
ENST00000585307 ENST00000579891 ENST00000577552 ENST00000582313 ENST00000584642
ENST00000581269 ENST00000581116 ENST00000581576 ENST00000578224 ENST00000580870
ENST00000580544
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for THOC1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for THOC1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: THOC1 (NM_005131) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for THOC1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat THOC1 |
Additional cDNA sequence: AK225067.1 AK225709.1 AK314755.1 AY573302.1 BC010381.1 L36529.1 20 DOTS entries: DT.216965 DT.95133371 DT.91707912 DT.100639435 DT.97774518 DT.100786550 DT.121091348 DT.92447227 DT.92447228 DT.95158861 DT.97804170 DT.100029137 DT.100786553 DT.100786556 DT.100786554 DT.121091372 DT.75185234 DT.91742185 DT.95133370 DT.95133414 24/153 AceView cDNA sequences (see all 153): BU677669 AK055354 AL556066 CR591724 R29125 AU118754 BU156486 CR596078 CR600665 CA421734 D20865 BM470869 AY573303 CD360089 BM839905 AK123530 AA748327 AA280748 AI040749 CR597833 AA825830 BQ430892 AL573397 AL519426
GeneLoc Exon Structure
5/10 Alternative Splicing Database (ASD) splice patterns (SP) for THOC1 (see all 10) About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15a | · | 15b | ^ | 16a | · | 16b | · | 16c | ^ | 17 | ^ | 18a | · | 18b | ^ | 19a | · |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | |
| ExUns: | 19b | · | 19c | ^ | 20a | · | 20b | ^ | 21a | · | 21b |
|---|
|
| SP1: | | | | | | | | | | | | | |
| SP2: | - | | - | | - | | | | | | | | |
| SP3: | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | |
ECgene alternative splicing isoforms for THOC1
|
Expression
for THOC1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| THOC1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CAACACCTGA
About this image
See THOC1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for THOC1
SOURCE GeneReport for Unigene cluster: Hs.712543
UniProtKB/Swiss-Prot: THOC1_HUMAN, Q96FV9Tissue specificity: Ubiquitous. Expressed in various cancer cell lines. Expressed at very low levels in normal breastepithelial cells and highly expressed in breast tumors. Expression is strongly associated with an aggressive phenotypeof breast tumors and expression correlates with tumor size and the metastatic state of the tumor progression
SABiosciences Custom PCR Arrays for THOC1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for THOC1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat THOC1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat THOC1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat THOC1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for THOC1 |
Orthologs
for THOC1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for THOC1 gene from 9/27 species (see all 27) About this table
ENSEMBL Gene Tree for THOC1 (if available)
TreeFam Gene Tree for THOC1 (if available) |
Paralogs
for THOC1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for THOC1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 18 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for THOC1 (214520 - 268059 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for THOC1: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing THOC1 |
|
Disorders
/ Diseases
for THOC1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
THOC1 for disorders About GeneDecksing
OMIM gene information: 606930
OMIM disorders: --
7  diseases for THOC1: About MalaCardskaposi's sarcoma hepatitis b sarcoma retinoblastoma
lung cancer breast cancer hepatitis
1 Novoseek disease relationship for THOC1 gene About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| cancer |
0 |
3 |
17638875 (3) |
Human Genome Epidemiology (HuGE) Navigator: THOC1 (1 document)
Export disorders for THOC1 gene to outside databases
|
Publications
for THOC1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for THOC1 gene, integrated from 9 sources (see all 47):
(articles sorted by number of sources associating them with THOC1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- TREX is a conserved complex coupling transcription with messenger RNA export. (PubMed id 11979277)1, 2, 3 Straesser K....Hurt E. (2002)
- Recruitment of the complete hTREX complex is required for Kaposi's sarcoma-associated herpesvirus intronless mRNA nuclear export and virus replication. (PubMed id 18974867)1, 2 Boyne J.R.... Whitehouse A. (2008)
- Human mRNA export machinery recruited to the 5' end of mRNA. (PubMed id 17190602)1, 2 Cheng H.... Reed R. (2006)
- Recruitment of the human TREX complex to mRNA during splicing. (PubMed id 15998806)1, 2 Masuda S.... Reed R. (2005)
- Human hHpr1/p84/Thoc1 regulates transcriptional elongation and physically links RNA polymerase II and RNA processing factors. (PubMed id 15870275)1, 2 Li Y.... Goodrich D.W. (2005)
- Linking transcriptional elongation and messenger RNA export to metastatic breast cancers. (PubMed id 15833825)1, 2 Guo S.... Shiekhattar R. (2005)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The death domain protein p84N5, but not the short isoform p84N5s, is cell cycle-regulated and shuttles between the nucleus and the cytoplasm. (PubMed id 15358532)1, 2 Gasparri F.... Muzio M. (2004)
- Apoptosis induced by the nuclear death domain protein p84N5 is inhibited by association with Rb protein. (PubMed id 10512864)1, 2 Doostzadeh-Cizeron J.... Goodrich D.W. (1999)
|
External Searches for THOC1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing THOC1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing THOC1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing THOC1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for THOC1 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for THOC1 gene:
Search GeneIP for patents involving THOC1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for THOC1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
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| | |  | OriGene Antibodies for THOC1 | | OriGene shRNA RFP for THOC1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for THOC1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for THOC1 | | | OriGene Protein Over-expression Lysate for THOC1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for THOC1 | | OriGene 3'-UTR Clone for THOC1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for THOC1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for THOC1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for THOC1 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for THOC1 | | OriGene Custom Protein Services for THOC1 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat THOC1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing THOC1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat THOC1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat THOC1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat THOC1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat THOC1 |
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| | | | Search Tocris compounds for THOC1 |
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 | | | THOC1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for THOC1 |
|  |  |  | | | | ThermoFisher Antibody for THOC1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat THOC1 |
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