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Aliases for THOC1 Gene

Aliases for THOC1 Gene

  • THO Complex 1 2 3
  • HPR1 3 4 6
  • Nuclear Matrix Protein P84 3 4
  • HTREX84 3 4
  • P84N5 3 4
  • THO1 3 4
  • THO Complex Subunit 1 3
  • P84 3

External Ids for THOC1 Gene

Previous GeneCards Identifiers for THOC1 Gene

  • GC18M000202

Summaries for THOC1 Gene

Entrez Gene Summary for THOC1 Gene

  • HPR1 is part of the TREX (transcription/export) complex, which includes TEX1 (MIM 606929), THO2 (MIM 300395), ALY (MIM 604171), and UAP56 (MIM 142560).[supplied by OMIM, Nov 2010]

GeneCards Summary for THOC1 Gene

THOC1 (THO Complex 1) is a Protein Coding gene. Among its related pathways are RNA transport and Spliceosome. GO annotations related to this gene include RNA binding.

UniProtKB/Swiss-Prot for THOC1 Gene

  • Required for efficient export of polyadenylated RNA. Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5 end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essential for the export of Kaposis sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. Regulates transcriptional elongation of a subset of genes. Involved in genome stability by preventing co-transcriptional R-loop formation

  • Participates in an apoptotic pathway which is characterized by activation of caspase-6, increases in the expression of BAK1 and BCL2L1 and activation of NF-kappa-B. This pathway does not require p53/TP53, nor does the presence of p53/TP53 affect the efficiency of cell killing. Activates a G2/M cell cycle checkpoint prior to the onset of apoptosis. Apoptosis is inhibited by association with RB1

Gene Wiki entry for THOC1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for THOC1 Gene

Genomics for THOC1 Gene

Regulatory Elements for THOC1 Gene

Genomic Location for THOC1 Gene

Start:
214,520 bp from pter
End:
268,059 bp from pter
Size:
53,540 bases
Orientation:
Minus strand

Genomic View for THOC1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for THOC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for THOC1 Gene

Proteins for THOC1 Gene

  • Protein details for THOC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96FV9-THOC1_HUMAN
    Recommended name:
    THO complex subunit 1
    Protein Accession:
    Q96FV9
    Secondary Accessions:
    • B2RBP6
    • Q15219
    • Q64I72
    • Q64I73

    Protein attributes for THOC1 Gene

    Size:
    657 amino acids
    Molecular mass:
    75666 Da
    Quaternary structure:
    • Component of the THO complex, which is composed of THOC1, THOC2, THOC3, THOC5, THOC6 and THOC7; together with at least ALYREF/THOC4, DDX39B, SARNP/CIP29 and CHTOP, THO forms the transcription/export (TREX) complex which seems to have a dynamic structure involving ATP-dependent remodeling. Binds to the hypophosphorylated form of RB1. Interacts with THOC2, THOC5, DDX39B and RNA polymerase II.

    Three dimensional structures from OCA and Proteopedia for THOC1 Gene

    Alternative splice isoforms for THOC1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for THOC1 Gene

Proteomics data for THOC1 Gene at MOPED

Post-translational modifications for THOC1 Gene

  • Expression is altered specifically during apoptosis and is accompanied by the appearance of novel forms with smaller apparent molecular mass
  • Polyubiquitinated, leading to proteasomal degradation; probably involves NEDD4.
  • Ubiquitination at Lys31 and Lys237
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for THOC1 Gene

Domains for THOC1 Gene

Gene Families for THOC1 Gene

HGNC:
  • THOC :THO complex subunits

Protein Domains for THOC1 Gene

Suggested Antigen Peptide Sequences for THOC1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96FV9

UniProtKB/Swiss-Prot:

THOC1_HUMAN :
  • Q96FV9
Domain:
  • An intact death domain is needed for apoptosis.
  • Contains 1 death domain.
genes like me logo Genes that share domains with THOC1: view

Function for THOC1 Gene

Molecular function for THOC1 Gene

UniProtKB/Swiss-Prot Function: Required for efficient export of polyadenylated RNA. Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5 end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essential for the export of Kaposis sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. Regulates transcriptional elongation of a subset of genes. Involved in genome stability by preventing co-transcriptional R-loop formation
UniProtKB/Swiss-Prot Function: Participates in an apoptotic pathway which is characterized by activation of caspase-6, increases in the expression of BAK1 and BCL2L1 and activation of NF-kappa-B. This pathway does not require p53/TP53, nor does the presence of p53/TP53 affect the efficiency of cell killing. Activates a G2/M cell cycle checkpoint prior to the onset of apoptosis. Apoptosis is inhibited by association with RB1
UniProtKB/Swiss-Prot Induction: Up-regulated during cell proliferation.

Gene Ontology (GO) - Molecular Function for THOC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003723 RNA binding IEA --
GO:0005515 protein binding IPI 15870275
genes like me logo Genes that share ontologies with THOC1: view
genes like me logo Genes that share phenotypes with THOC1: view

Animal Models for THOC1 Gene

MGI Knock Outs for THOC1:

miRNA for THOC1 Gene

miRTarBase miRNAs that target THOC1

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for THOC1 Gene

Localization for THOC1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for THOC1 Gene

Isoform 1: Nucleus speckle. Nucleus, nucleoplasm. Nucleus matrix. Cytoplasm. Note=Can shuttle between the nucleus and cytoplasm. Nuclear localization is required for induction of apoptotic cell death. Translocates to the cytoplasm during the early phase of apoptosis execution.
Isoform 2: Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for THOC1 Gene COMPARTMENTS Subcellular localization image for THOC1 gene
Compartment Confidence
nucleus 5
cytosol 1
golgi apparatus 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for THOC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000346 transcription export complex IDA 15833825
GO:0000347 THO complex IDA 15998806
GO:0000445 THO complex part of transcription export complex IDA 15998806
GO:0005634 nucleus IDA 15358532
GO:0005654 nucleoplasm IDA --
genes like me logo Genes that share ontologies with THOC1: view

Pathways for THOC1 Gene

SuperPathways for THOC1 Gene

Superpath Contained pathways
1 RNA transport
2 Spliceosome
genes like me logo Genes that share pathways with THOC1: view

Pathways by source for THOC1 Gene

2 KEGG pathways for THOC1 Gene

Gene Ontology (GO) - Biological Process for THOC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000018 regulation of DNA recombination IMP 22144908
GO:0006351 transcription, DNA-templated IEA --
GO:0006396 RNA processing TAS 7525595
GO:0006397 mRNA processing IEA --
GO:0006406 mRNA export from nucleus IMP 22144908
genes like me logo Genes that share ontologies with THOC1: view

Transcripts for THOC1 Gene

Unigene Clusters for THOC1 Gene

THO complex 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for THOC1 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16a · 16b · 16c ^ 17 ^ 18a · 18b ^ 19a ·
SP1:
SP2: -
SP3: -
SP4: -
SP5: -
SP6:
SP7:
SP8: -
SP9:
SP10:

ExUns: 19b · 19c ^ 20a · 20b ^ 21a · 21b
SP1:
SP2: - - -
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:

Relevant External Links for THOC1 Gene

GeneLoc Exon Structure for
THOC1
ECgene alternative splicing isoforms for
THOC1

Expression for THOC1 Gene

mRNA expression in normal human tissues for THOC1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for THOC1 Gene

SOURCE GeneReport for Unigene cluster for THOC1 Gene Hs.712543

mRNA Expression by UniProt/SwissProt for THOC1 Gene

Q96FV9-THOC1_HUMAN
Tissue specificity: Ubiquitous. Expressed in various cancer cell lines. Expressed at very low levels in normal breast epithelial cells and highly expressed in breast tumors. Expression is strongly associated with an aggressive phenotype of breast tumors and expression correlates with tumor size and the metastatic state of the tumor progression.
genes like me logo Genes that share expressions with THOC1: view

No data available for mRNA differential expression in normal tissues for THOC1 Gene

Orthologs for THOC1 Gene

This gene was present in the common ancestor of animals.

Orthologs for THOC1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia THOC1 35
  • 99.59 (n)
  • 99.7 (a)
THOC1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia THOC1 35
  • 93.4 (n)
  • 97.56 (a)
THOC1 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia THOC1 35
  • 95.08 (n)
  • 98.48 (a)
THOC1 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Thoc1 35
  • 90.72 (n)
  • 96.19 (a)
Thoc1 16
Thoc1 36
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia THOC1 36
  • 94 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia THOC1 36
  • 86 (a)
OneToOne
chicken
(Gallus gallus)
Aves THOC1 35
  • 80.69 (n)
  • 90.06 (a)
THOC1 36
  • 90 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia THOC1 36
  • 86 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.6752 35
thoc1 35
  • 74.68 (n)
  • 79.79 (a)
zebrafish
(Danio rerio)
Actinopterygii thoc1 35
  • 70.22 (n)
  • 75.77 (a)
thoc1 36
  • 74 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004070 35
  • 49.38 (n)
  • 46.61 (a)
fruit fly
(Drosophila melanogaster)
Insecta Hpr1 35
  • 50.85 (n)
  • 46.44 (a)
Hpr1 36
  • 35 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea thoc-1 35
  • 47.55 (n)
  • 38.07 (a)
thoc-1 36
  • 28 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3777 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1856 36
  • 46 (a)
OneToOne
Species with no ortholog for THOC1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for THOC1 Gene

ENSEMBL:
Gene Tree for THOC1 (if available)
TreeFam:
Gene Tree for THOC1 (if available)

Paralogs for THOC1 Gene

No data available for Paralogs for THOC1 Gene

Variants for THOC1 Gene

Sequence variations from dbSNP and Humsavar for THOC1 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type MAF
rs11309 -- 214,486(-) AACAA(C/T)AGAAC downstream-variant-500B
rs472229 -- 235,056(+) TTTCC(C/T)TAATG intron-variant
rs472882 -- 235,074(+) ATTTA(A/T)TTGGt intron-variant
rs481077 -- 218,695(-) TAAGC(A/G)TGACT intron-variant
rs484168 -- 258,809(+) AAAAT(C/T)TGTTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for THOC1 Gene

Variant ID Type Subtype PubMed ID
nsv518642 CNV Gain 19592680
nsv909287 CNV Gain 21882294
nsv2174 CNV Loss 18451855

Relevant External Links for THOC1 Gene

HapMap Linkage Disequilibrium report
THOC1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for THOC1 Gene

Disorders for THOC1 Gene

(1) Novoseek inferred disease relationships for THOC1 Gene

Disease -log(P) Hits PubMed IDs
cancer 0 3

Relevant External Links for THOC1

Genetic Association Database (GAD)
THOC1
Human Genome Epidemiology (HuGE) Navigator
THOC1
genes like me logo Genes that share disorders with THOC1: view

No data available for UniProtKB/Swiss-Prot for THOC1 Gene

Publications for THOC1 Gene

  1. TREX is a conserved complex coupling transcription with messenger RNA export. (PMID: 11979277) Straesser K. … Hurt E. (Nature 2002) 2 3 4
  2. Recruitment of the human TREX complex to mRNA during splicing. (PMID: 15998806) Masuda S. … Reed R. (Genes Dev. 2005) 2 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The death domain protein p84N5, but not the short isoform p84N5s, is cell cycle-regulated and shuttles between the nucleus and the cytoplasm. (PMID: 15358532) Gasparri F. … Muzio M. (FEBS Lett. 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for THOC1 Gene

  • Addgene plasmids for THOC1

Sources for THOC1 Gene

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