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THOC1 Gene

protein-coding   GIFtS: 57
GCID: GC18M000204

THO Complex 1

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
THO Complex 11 2     P84N52
HPR12 3 5     THO Complex Subunit 12
Nuclear Matrix Protein P842 3     tho12
hTREX842 3     Tho13
P842     p84N53

External Ids:    HGNC: 190701   Entrez Gene: 99842   Ensembl: ENSG000000791347   OMIM: 6069305   UniProtKB: Q96FV93   

Export aliases for THOC1 gene to outside databases

Previous GC identifer: GC18M000202


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for THOC1 Gene:
HPR1 is part of the TREX (transcription/export) complex, which includes TEX1 (MIM 606929), THO2 (MIM 300395), ALY
(MIM 604171), and UAP56 (MIM 142560).(supplied by OMIM, Nov 2010)

GeneCards Summary for THOC1 Gene:
THOC1 (THO complex 1) is a protein-coding gene. GO annotations related to this gene include RNA binding.

UniProtKB/Swiss-Prot: THOC1_HUMAN, Q96FV9
Function: Required for efficient export of polyadenylated RNA. Acts as component of the THO subcomplex of the TREX
complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically
associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a
transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited
in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export
to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essential for the export of Kaposi's
sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. Regulates transcriptional
elongation of a subset of genes. Involved in genome stability by preventing co-transcriptional R-loop formation
Function: Participates in an apoptotic pathway which is characterized by activation of caspase-6, increases in the
expression of BAK1 and BCL2L1 and activation of NF-kappa-B. This pathway does not require p53/TP53, nor does the
presence of p53/TP53 affect the efficiency of cell killing. Activates a G2/M cell cycle checkpoint prior to the
onset of apoptosis. Apoptosis is inhibited by association with RB1

Gene Wiki entry for THOC1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the THOC1 gene promoter:
         p53   POU3F2 (N-Oct-5a)   POU6F1 (c2)   CUTL1   POU3F2   Evi-1   FOXL1   PPAR-alpha   POU2F1   POU2F1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTHOC1 promoter sequence
   Search Chromatin IP Primers for THOC1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat THOC1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 18p11.32   Ensembl cytogenetic band:  18p11.32   HGNC cytogenetic band: 18p11.32

THOC1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
THOC1 gene location

GeneLoc information about chromosome 18         GeneLoc Exon Structure

GeneLoc location for GC18M000204:  view genomic region     (about GC identifiers)

Start:
214,520 bp from pter      End:
268,059 bp from pter
Size:
53,540 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: THOC1_HUMAN, Q96FV9 (See protein sequence)
Recommended Name: THO complex subunit 1  
Size: 657 amino acids; 75666 Da
Subunit: Component of the THO complex, which is composed of THOC1, THOC2, THOC3, THOC5, THOC6 and THOC7; together
with at least ALYREF/THOC4, DDX39B, SARNP/CIP29 and CHTOP, THO forms the transcription/export (TREX) complex
which seems to have a dynamic structure involving ATP-dependent remodeling. Binds to the hypophosphorylated form
of RB1. Interacts with THOC2, THOC5, DDX39B and RNA polymerase II
1 PDB 3D structure from and Proteopedia for THOC1:
1WXP (3D)    
Secondary accessions: B2RBP6 Q15219 Q64I72 Q64I73
Alternative splicing: 2 isoforms:  Q96FV9-1   Q96FV9-2   (May be due to an intron retention)

Explore the universe of human proteins at neXtProt for THOC1: NX_Q96FV9

Explore proteomics data for THOC1 at MOPED

Post-translational modifications: 

  • Expression is altered specifically during apoptosis and is accompanied by the appearance of novel forms with
    smaller apparent molecular mass1
  • Polyubiquitinated, leading to proteasomal degradation; probably involves NEDD41
  • Ubiquitination2 at Lys31, Lys237
  • Modification sites at PhosphoSitePlus

  • See THOC1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_005122.2  
    ENSEMBL proteins: 
     ENSP00000462757   ENSP00000261600   ENSP00000473276   ENSP00000473499   ENSP00000463965  
     ENSP00000461943  

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    antibodies-online proteins for THOC1 (5 products) 

     
    antibodies-online peptides for THOC1

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    THOC: THO complex subunits

    3 InterPro protein domains:
     IPR011029 DEATH-like_dom
     IPR000488 Death_domain
     IPR021861 THO_THOC1

    Graphical View of Domain Structure for InterPro Entry Q96FV9

    ProtoNet protein and cluster: Q96FV9

    1 Blocks protein domain: IPB000488 Death domain

    UniProtKB/Swiss-Prot: THOC1_HUMAN, Q96FV9
    Domain: An intact death domain is needed for apoptosis
    Similarity: Contains 1 death domain


    Find genes that share domains with THOC1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: THOC1_HUMAN, Q96FV9
    Function: Required for efficient export of polyadenylated RNA. Acts as component of the THO subcomplex of the TREX
    complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically
    associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a
    transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited
    in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export
    to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essential for the export of Kaposi's
    sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. Regulates transcriptional
    elongation of a subset of genes. Involved in genome stability by preventing co-transcriptional R-loop formation
    Function: Participates in an apoptotic pathway which is characterized by activation of caspase-6, increases in the
    expression of BAK1 and BCL2L1 and activation of NF-kappa-B. This pathway does not require p53/TP53, nor does the
    presence of p53/TP53 affect the efficiency of cell killing. Activates a G2/M cell cycle checkpoint prior to the
    onset of apoptosis. Apoptosis is inhibited by association with RB1
    Induction: Up-regulated during cell proliferation

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0003723RNA binding IEA--
    GO:0005515protein binding IPI15870275
         
    Find genes that share ontologies with THOC1           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for THOC1:
     Increased gamma-H2AX phosphory  Synthetic lethal with Ras 

         4 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Thoc1):
     cellular  embryogenesis  growth/size/body  mortality/aging 

    Find genes that share phenotypes with THOC1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Thoc1tm1Dwg for THOC1

       genOway: Develop your customized and physiologically relevant rodent model for THOC1

    miRNA
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    miRTarBase miRNAs that target THOC1:
    hsa-mir-186-5p (MIRT045303)

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    hsa-miR-105
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    THOC1_HUMAN, Q96FV9: Isoform 1: Nucleus speckle. Nucleus, nucleoplasm. Nucleus matrix. Cytoplasm. Note=Can
    shuttle between the nucleus and cytoplasm. Nuclear localization is required for induction of apoptotic cell
    death. Translocates to the cytoplasm during the early phase of apoptosis execution
    THOC1_HUMAN, Q96FV9: Isoform 2: Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol1
    golgi apparatus1
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): Selected cellular component terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000346transcription export complex IDA15833825
    GO:0000347THO complex IDA15998806
    GO:0000445THO complex part of transcription export complex IDA15998806
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--

    Find genes that share ontologies with THOC1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for THOC1 About    
    See pathways by source

    SuperPathContained pathways About
    1Spliceosome
    Spliceosome
    2RNA transport
    RNA transport


    Find genes that share SuperPaths with THOC1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways




    2 Kegg Pathways  (Kegg details for THOC1):
        RNA transport
    Spliceosome

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for THOC1
    Interactions:

        Search GeneGlobe Interaction Network for THOC1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 22)

    Selected Interacting proteins for THOC1 (Q96FV91, 2, 3 ENSP000002616004) via UniProtKB, MINT, STRING, and/or I2D (see all 604)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    THOC5Q137691, 2, 3, ENSP000003809694EBI-1765605,EBI-5280316 MINT-6800052 MINT-6800071 MINT-7040368 MINT-7040334 MINT-7040353 MINT-6800089 MINT-7040173 MINT-8337959 I2D: score=1 STRING: ENSP00000380969
    DDX39BQ138382, 3MINT-7945693 I2D: score=1 
    ENSG00000215425Q138382, 3MINT-7945693 I2D: score=1 
    ENSG00000225073Q138382, 3MINT-7945693 I2D: score=1 
    ENSG00000225859Q138382, 3MINT-7945693 I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000018regulation of DNA recombination IMP--
    GO:0006351transcription, DNA-templated IEA--
    GO:0006396RNA processing TAS7525595
    GO:0006397mRNA processing IEA--
    GO:0006406mRNA export from nucleus IMP--

    Find genes that share ontologies with THOC1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for THOC1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for THOC1 gene: 
    NM_005131.2  

    18 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000579232(uc002kkl.2) ENST00000577429 ENST00000583228 ENST00000578529
    ENST00000580038 ENST00000261600(uc002kkj.4) ENST00000584470(uc002kkh.4)
    ENST00000585307 ENST00000579891 ENST00000577552 ENST00000582313 ENST00000584642
    ENST00000581269 ENST00000581116 ENST00000581576 ENST00000578224 ENST00000580870
    ENST00000580544
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    Selected AceView cDNA sequences (see all 153):

    BU156486 AY573303 D20865 CR591724 CR597833 CR596078 BM839905 CD360089 
    AK055354 CA421734 BM470869 AK123530 AA748327 R29125 AI040749 AL556066 
    BU677669 AU118754 CR600665 AA280748 BU152679 BG111932 AA808061 BU528459 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for THOC1 (see all 10)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16a · 16b · 16c ^ 17 ^ 18a · 18b ^ 19a ·
    SP1:                                                                                                                                                            
    SP2:                                                                                                                                            -               
    SP3:                                                                                      -                                                                     
    SP4:                          -                                                                                                                                 
    SP5:                                                                                                                                            -               

    ExUns: 19b · 19c ^ 20a · 20b ^ 21a · 21b
    SP1:                                    
    SP2:  -     -     -                     
    SP3:                                    
    SP4:                                    
    SP5:                                    


    ECgene alternative splicing isoforms for THOC1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    THOC1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAACACCTGA
    THOC1 Expression
    About this image


    THOC1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Pancreas (Endocrine System)
             Islets of Langerhans
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Bone (Muscoskeletal System)
             Bone Marrow
    THOC1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    THOC1 Protein Expression

    UniProtKB/Swiss-Prot: THOC1_HUMAN, Q96FV9
    Tissue specificity: Ubiquitous. Expressed in various cancer cell lines. Expressed at very low levels in normal
    breast epithelial cells and highly expressed in breast tumors. Expression is strongly associated with an
    aggressive phenotype of breast tumors and expression correlates with tumor size and the metastatic state of the
    tumor progression

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for THOC1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for THOC1 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Thoc11 , 5 THO complex 11, 5 90.72(n)1
    96.19(a)1
      18 (4.91 cM)5
    2251601  NM_153552.31  NP_705780.11 
     99581805 
    chicken
    (Gallus gallus)
    Aves THOC11 THO complex 1 80.69(n)
    90.06(a)
      421062  XM_419149.4  XP_419149.4 
    lizard
    (Anolis carolinensis)
    Reptilia THOC16
    THO complex 1
    86(a)
    1 ↔ 1
    4(39319167-39341108)
    African clawed frog
    (Xenopus laevis)
    Amphibia BC044699.12   -- 75.35(n)    BC044699.1 
    zebrafish
    (Danio rerio)
    Actinopterygii thoc12 THO complex 1 79.1(n)   373077  BC054938.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Hpr11 Hpr1 50.85(n)
    46.44(a)
      40723  NM_141337.2  NP_649594.1 
    worm
    (Caenorhabditis elegans)
    Secernentea thoc-11 thoc-1 47.55(n)
    38.07(a)
      173460  NM_061395.2  NP_493796.2 


    ENSEMBL Gene Tree for THOC1 (if available)
    TreeFam Gene Tree for THOC1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for THOC1 (see all 1113)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 18 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs673308791,2
    C--204042(+) TGATT-/GA    
       T
    /TGA
    GATAG
    2 -- cds11NA 2
    rs5166291,2
    F,H--214297(-) TGTTAG/CTAGTT 1 -- ds50017Minor allele frequency- C:0.00MN NS EA NA 606
    rs113091,2
    F--214486(-) AACAAT/CAGAAC 1 -- ds50011Minor allele frequency- C:0.00MN 184
    rs30841761,2
    C--214521(+) TTGTT-/GTTATAAA 1 -- cds10--------
    rs1859862371,2
    --214526(+) TGTTAC/TAAAAA 1 -- ut310--------
    rs6575411,2
    C,H--214643(+) CTCATT/GGTCAT 2 /N /H mis19Minor allele frequency- G:0.00EA NA MN NS 646
    rs2014762251,2
    C--214848(+) TTCCAC/TTGTTC 2 Q syn10--------
    rs2017375921,2
    C--214849(+) TCCATT/CGTTCA 2 /Q /R mis11Minor allele frequency- C:0.00EU 593
    rs2006035221,2
    --214853(+) TTGTTC/TACCCA 2 K E mis10--------
    rs73430431,2
    C,F,H--214918(+) CATCAG/AGACCT 2 /P /L mis1 ese39Minor allele frequency- A:0.01NS EA NA 858

    HapMap Linkage Disequilibrium report for THOC1 (214520 - 268059 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for THOC1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv2174CNV Loss18451855
    nsv518642CNV Gain19592680
    nsv909287CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing THOC1
    DNA2.0 Custom Variant and Variant Library Synthesis for THOC1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 606930    OMIM disorders: --


    Find genes that share disorders with THOC1           About GenesLikeMe

    1 Novoseek inferred disease relationship for THOC1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cancer 0 3 17638875 (3)

    Genetic Association Database (GAD): THOC1
    Human Genome Epidemiology (HuGE) Navigator: THOC1 (1 document)

    Export disorders for THOC1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for THOC1 gene, integrated from 10 sources (see all 51):
    (articles sorted by number of sources associating them with THOC1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. TREX is a conserved complex coupling transcription with messenger RNA export. (PubMed id 11979277)1, 2, 3 Straesser K....Hurt E. (Nature 2002)
    2. The Thoc1 encoded ribonucleoprotein is a substrate for the NEDD4-1 E3 ubiquitin protein ligase. (PubMed id 23460917)1, 2 Song F....Goodrich D.W. (PLoS ONE 2013)
    3. Genome instability and transcription elongation impairment in human cells depleted of THO/TREX. (PubMed id 22144908)1, 2 DomA-nguez-SA!nchez M.S....Aguilera A. (PLoS Genet. 2011)
    4. Meta-analysis of genome-wide association data of bipolar disorder and major depressive disorder. (PubMed id 20351715)1, 4 Liu Y....Sullivan P.F. (Mol. Psychiatry 2011)
    5. Recruitment of the complete hTREX complex is required for Kaposi's sarcoma-associated herpesvirus intronless mRNA nuclear export and virus replication. (PubMed id 18974867)1, 2 Boyne J.R.... Whitehouse A. (PLoS Pathog. 2008)
    6. Human mRNA export machinery recruited to the 5' end of mRNA. (PubMed id 17190602)1, 2 Cheng H.... Reed R. (Cell 2006)
    7. Recruitment of the human TREX complex to mRNA during splicing. (PubMed id 15998806)1, 2 Masuda S.... Reed R. (Genes Dev. 2005)
    8. Human hHpr1/p84/Thoc1 regulates transcriptional elongation and physically links RNA polymerase II and RNA processing factors. (PubMed id 15870275)1, 2 Li Y.... Goodrich D.W. (Mol. Cell. Biol. 2005)
    9. Linking transcriptional elongation and messenger RNA export to metastatic breast cancers. (PubMed id 15833825)1, 2 Guo S.... Shiekhattar R. (Cancer Res. 2005)
    10. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9984 HGNC: 19070 AceView: THOC1 Ensembl:ENSG00000079134 euGenes: HUgn9984
    ECgene: THOC1 Kegg: 9984 H-InvDB: THOC1

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for THOC1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for THOC1 gene:
    Search GeneIP for patents involving THOC1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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