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THNSL2 Gene(Protein Coding)

Threonine Synthase Like 2

GCID:
GC02P088170
GIFtS:
50
Genes Participants
UDN Logo

Aliases for THNSL2 Gene

Aliases for THNSL2 Gene

  • Threonine Synthase Like 2 2 3
  • Secreted Osteoclastogenic Factor Of Activated T Cells 2 3
  • SOFAT 3 4
  • TSH2 3 4
  • Secreted Osteoclastogenic Factor Of Activated T-Cells 4
  • Threonine Synthase-Like 2 (S. Cerevisiae) 2
  • Threonine Synthase-Like 2 5
  • EC 4.2.3.1 63
  • EC 4.2.3.- 4
  • EC 4.2.3 63
  • THS2 3

External Ids for THNSL2 Gene

Previous GeneCards Identifiers for THNSL2 Gene

  • GC02P088251
  • GC02P088469
  • GC02P087392

Summaries for THNSL2 Gene

Entrez Gene Summary for THNSL2 Gene

  • This gene encodes a threonine synthase-like protein. A similar enzyme in mouse can catalyze the degradation of O-phospho-homoserine to a-ketobutyrate, phosphate, and ammonia. This protein also has phospho-lyase activity on both gamma and beta phosphorylated substrates. In mouse an alternatively spliced form of this protein has been shown to act as a cytokine and can induce the production of the inflammatory cytokine IL6 in osteoblasts. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2011]

GeneCards Summary for THNSL2 Gene

THNSL2 (Threonine Synthase Like 2) is a Protein Coding gene. GO annotations related to this gene include cytokine activity and lyase activity. An important paralog of this gene is THNSL1.

UniProtKB/Swiss-Prot for THNSL2 Gene

  • Isoform 1: Acts as a catabolic phospho-lyase on both gamma- and beta-phosphorylated substrates. Degrades O-phospho-threonine (PThr) to alpha-ketobutyrate, ammonia and phosphate (By similarity).

  • Isoform SOFAT: Potent inducer of osteoblastic production of IL6. May act to exacerbate inflammation and/or bone turnover under inflammatory conditions.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for THNSL2 Gene

Genomics for THNSL2 Gene

Products:

  1. Regulatory Element

Regulatory Elements for THNSL2 Gene

Enhancers for THNSL2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around THNSL2 on UCSC Golden Path with GeneCards custom track

Promoters for THNSL2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around THNSL2 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the THNSL2 gene promoter:

Genomic Location for THNSL2 Gene

Chromosome:
2
Start:
88,170,295 bp from pter
End:
88,186,637 bp from pter
Size:
16,343 bases
Orientation:
Plus strand

Genomic View for THNSL2 Gene

Genes around THNSL2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
THNSL2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for THNSL2 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for THNSL2 Gene

Proteins for THNSL2 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for THNSL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86YJ6-THNS2_HUMAN
    Recommended name:
    Threonine synthase-like 2
    Protein Accession:
    Q86YJ6
    Secondary Accessions:
    • B3KTB1
    • B5MDX8
    • B7WPF8
    • D9ZZB8
    • Q6P2M7
    • Q6PI27
    • Q9NV54

    Protein attributes for THNSL2 Gene

    Size:
    484 amino acids
    Molecular mass:
    54116 Da
    Cofactor:
    Name=pyridoxal 5-phosphate; Xref=ChEBI:CHEBI:597326;
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAX88906.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=BAA91904.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for THNSL2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for THNSL2 Gene

Proteomics data for THNSL2 Gene at MOPED

Protein Expression for THNSL2 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Selected DME Specific Peptides for THNSL2 Gene

Q86YJ6:

Post-translational modifications for THNSL2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for THNSL2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

Domains & Families for THNSL2 Gene

Protein Domains for THNSL2 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for THNSL2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q86YJ6

UniProtKB/Swiss-Prot:

THNS2_HUMAN :
  • Belongs to the threonine synthase family.
Family:
  • Belongs to the threonine synthase family.
genes like me logo Genes that share domains with THNSL2: view

No data available for Gene Families for THNSL2 Gene

Function for THNSL2 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line
  7. Flow Cytometry

Molecular function for THNSL2 Gene

UniProtKB/Swiss-Prot Function:
Isoform 1: Acts as a catabolic phospho-lyase on both gamma- and beta-phosphorylated substrates. Degrades O-phospho-threonine (PThr) to alpha-ketobutyrate, ammonia and phosphate (By similarity).
UniProtKB/Swiss-Prot Function:
Isoform SOFAT: Potent inducer of osteoblastic production of IL6. May act to exacerbate inflammation and/or bone turnover under inflammatory conditions.

Enzyme Numbers (IUBMB) for THNSL2 Gene

Gene Ontology (GO) - Molecular Function for THNSL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030170 pyridoxal phosphate binding IEA,ISS 17034760
genes like me logo Genes that share ontologies with THNSL2: view

Phenotypes for THNSL2 Gene

GenomeRNAi human phenotypes for THNSL2:
genes like me logo Genes that share phenotypes with THNSL2: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for THNSL2 Gene

Localization for THNSL2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for THNSL2 Gene

Isoform SOFAT: Secreted. Note=Secreted by activated T-cells via a calcineurin-independent pathway.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for THNSL2 Gene COMPARTMENTS Subcellular localization image for THNSL2 gene
Compartment Confidence
extracellular 5
cytosol 2
mitochondrion 2
nucleus 1
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for THNSL2 Gene

Pathways & Interactions for THNSL2 Gene

SuperPathways for THNSL2 Gene

PathCards logoMore details on SuperPathways for THNSL2
No Data Available

Gene Ontology (GO) - Biological Process for THNSL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009088 NOT threonine biosynthetic process IBA --
genes like me logo Genes that share ontologies with THNSL2: view

No data available for Pathways by source and SIGNOR curated interactions for THNSL2 Gene

Drugs & Compounds for THNSL2 Gene

Products:

  1. Drug

(1) Drugs for THNSL2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Pyridoxal Phosphate Nutra 14
genes like me logo Genes that share compounds with THNSL2: view

Transcripts for THNSL2 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

mRNA/cDNA for THNSL2 Gene

(17) REFSEQ mRNAs :
(10) Additional mRNA sequences :
(140) Selected AceView cDNA sequences:
(10) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for THNSL2 Gene

Threonine synthase-like 2 (S. cerevisiae):
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for THNSL2 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c · 4d ^ 5a · 5b ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12 ^ 13a ·
SP1: - - - - - -
SP2: - - -
SP3: - - - - -
SP4: - - - -
SP5: - - - -
SP6: - - - -
SP7: - -
SP8: - - - - - - - -
SP9: -
SP10:
SP11:

ExUns: 13b · 13c · 13d
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:

Relevant External Links for THNSL2 Gene

GeneLoc Exon Structure for
THNSL2
ECgene alternative splicing isoforms for
THNSL2

Expression for THNSL2 Gene

Products:

  1. Primer

mRNA expression in normal human tissues for THNSL2 Gene

mRNA expression in normal human tissues for THNSL2 Gene
mRNA expression by BioGPS for THNSL2 GenemRNA expression by GTEx for THNSL2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for THNSL2 Gene

This gene is overexpressed in Retina (28.0), Platelet (19.3), Testis (7.4), and Prostate (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for THNSL2 Gene



SOURCE GeneReport for Unigene cluster for THNSL2 Gene Hs.740434

genes like me logo Genes that share expression patterns with THNSL2: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for THNSL2 Gene

Orthologs for THNSL2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for THNSL2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
 Mammalia THNSL2 35
  • 86.14 (n)
  • 86.69 (a)
THNSL2 36
  • 86 (a)
 OneToOne
dog
(Canis familiaris)
 Mammalia THNSL2 35
  • 87.6 (n)
  • 86.36 (a)
THNSL2 36
  • 86 (a)
 OneToOne
mouse
(Mus musculus)
 Mammalia Thnsl2 35
  • 84.33 (n)
  • 83.44 (a)
Thnsl2 16
Thnsl2 36
  • 83 (a)
 OneToOne
chimpanzee
(Pan troglodytes)
 Mammalia THNSL2 35
  • 99.45 (n)
  • 99.17 (a)
THNSL2 36
  • 99 (a)
 OneToOne
rat
(Rattus norvegicus)
 Mammalia Thnsl2 35
  • 84.16 (n)
  • 83.88 (a)
oppossum
(Monodelphis domestica)
 Mammalia THNSL2 36
  • 65 (a)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia THNSL2 36
  • 70 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves THNSL2 35
  • 69.75 (n)
  • 68.63 (a)
THNSL2 36
  • 66 (a)
 OneToOne
lizard
(Anolis carolinensis)
 Reptilia THNSL2 36
  • 66 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia thnsl2 35
  • 64.47 (n)
  • 60.93 (a)
zebrafish
(Danio rerio)
 Actinopterygii thnsl2 35
  • 58.53 (n)
  • 53.26 (a)
thnsl2 36
  • 53 (a)
 OneToOne
K. lactis yeast
(Kluyveromyces lactis)
 Saccharomycetes KLLA0C09020g 35
  • 47.69 (n)
  • 39.61 (a)
baker's yeast
(Saccharomyces cerevisiae)
 Saccharomycetes THR4 35
  • 47.8 (n)
  • 39.31 (a)
THR4 36
  • 34 (a)
 OneToMany
THR4 38
bread mold
(Neurospora crassa)
 Ascomycetes NCU03425 35
  • 48.92 (n)
  • 38.53 (a)
fission yeast
(Schizosaccharomyces pombe)
 Schizosaccharomycetes SPAC9E9.06c 35
  • 46.57 (n)
  • 39.24 (a)
sea squirt
(Ciona savignyi)
 Ascidiacea -- 36
  • 44 (a)
 OneToOne
Species with no ortholog for THNSL2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for THNSL2 Gene

ENSEMBL:
Gene Tree for THNSL2 (if available)
TreeFam:
Gene Tree for THNSL2 (if available)

Paralogs for THNSL2 Gene

Paralogs for THNSL2 Gene

genes like me logo Genes that share paralogs with THNSL2: view

Variants for THNSL2 Gene

Sequence variations from dbSNP and Humsavar for THNSL2 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs4129190 - 88,173,272(+) CAGAG(A/G)GACCC intron-variant, reference, missense
rs35541720 - 88,174,737(-) TGTGA(C/T)GCCAT intron-variant, reference, missense, utr-variant-5-prime
rs34136143 - 88,178,822(-) ACACA(G/T)TCTTG reference, missense
rs17855905 - 88,182,966(+) TGGAG(A/G)GGGTG intron-variant, reference, missense
rs1878810 -- 88,185,873(+) TCCGG(C/G)TGCCA intron-variant, downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for THNSL2 Gene

Variant ID Type Subtype PubMed ID
dgv61n16 CNV Deletion 17901297
nsv874581 CNV Gain 21882294
nsv834289 CNV Gain 17160897
esv2518093 CNV Insertion 19546169
esv1550357 CNV Insertion 17803354
esv1593020 CNV Insertion 17803354
nsv507021 CNV Insertion 20534489

Variation tolerance for THNSL2 Gene

Residual Variation Intolerance Score: 90.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.63; 65.58% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for THNSL2 Gene

HapMap Linkage Disequilibrium report
THNSL2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for THNSL2 Gene

Disorders for THNSL2 Gene

Relevant External Links for THNSL2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
THNSL2

No disorders were found for THNSL2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for THNSL2 Gene

Publications for THNSL2 Gene

  1. A novel T cell cytokine, secreted osteoclastogenic factor of activated T cells, induces osteoclast formation in a RANKL-independent manner. (PMID: 19877052) Rifas L. … Weitzmann M.N. (Arthritis Rheum. 2009) 2 3 4 67
  2. A threonine synthase homolog from a mammalian genome. (PMID: 17034760) Donini S. … Peracchi A. (Biochem. Biophys. Res. Commun. 2006) 2 3
  3. In vitro evaluation of the biological effect of SOFAT on osteoblasts. (PMID: 25916677) Napimoga M.H. … Martinez E.F. (Int. Immunopharmacol. 2015) 3
  4. Secreted osteoclastogenic factor of activated T cells (SOFAT), a novel osteoclast activator, in chronic periodontitis. (PMID: 23619471) Jarry C.R. … Napimoga M.H. (Hum. Immunol. 2013) 3
  5. Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women. (PMID: 22589738) Fox C.S. … Borecki I.B. (PLoS Genet. 2012) 3

Products for THNSL2 Gene

Sources for THNSL2 Gene

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