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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

THNSL2 Gene

protein-coding   GIFtS: 53
GCID: GC02P088469

Threonine Synthase-Like 2 (S. Cerevisiae)
Microbiology & Infectious Diseases Congress
  See related disease
at
MalaCards
 

Aliases
for THNSL2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section
Aliases
Threonine Synthase-Like 2 (S. Cerevisiae)1 2     Threonine Synthase-Like 22
SOFAT2 3     EC 4.2.3.-3
TSH22 3     Secreted Osteoclastogenic Factor Of Activated T-Cells3
THS22     EC 4.2.38
Secreted Osteoclastogenic Factor Of Activated T Cells2     EC 4.2.3.18

External Ids:    HGNC: 256021   Entrez Gene: 552582   Ensembl: ENSG000001441157   OMIM: 6112615   UniProtKB: Q86YJ63   

Export aliases for THNSL2 gene to outside databases

Previous GC identifers: GC02P088251 GC02P087392


Summaries
for THNSL2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for THNSL2 Gene:
This gene encodes a threonine synthase-like protein. A similar enzyme in mouse can catalyze the degradation of
O-phospho-homoserine to a-ketobutyrate, phosphate, and ammonia. This protein also has phospho-lyase activity on
both gamma and beta phosphorylated substrates. In mouse an alternatively spliced form of this protein has been
shown to act as a cytokine and can induce the production of the inflammatory cytokine IL6 in osteoblasts.
Alternate splicing results in multiple transcript variants. (provided by RefSeq, Sep 2011)

GeneCards Summary for THNSL2 Gene: 
THNSL2 (threonine synthase-like 2 (S. cerevisiae)) is a protein-coding gene. Diseases associated with THNSL2 include pneumonia. GO annotations related to this gene include pyridoxal phosphate binding and molecular_function. An important paralog of this gene is THNSL1.

UniProtKB/Swiss-Prot: THNS2_HUMAN, Q86YJ6
Function: Isoform 1: Acts as a catabolic phospho-lyase on both gamma- and beta-phosphorylated substrates. Degrades
O-phospho-threonine (PThr) to alpha-ketobutyrate, ammonia and phosphate (By similarity)
Function: Isoform SOLAT: Potent inducer of osteoblastic production of IL6. May act to exacerbate inflammation
and/or bone turnover under inflammatory conditions




Genomic Views
for THNSL2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NT_022184.15  NC_018913.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the THNSL2 gene promoter:
         Nkx3-1   AhR   Nkx3-1 v4   AML1a   Nkx3-1 v1   Arnt   Nkx3-1 v2   COMP1   Nkx3-1 v3   c-Myb   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: THNSL2 promoter sequence
   Search SABiosciences Chromatin IP Primers for THNSL2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat THNSL2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p11.2   Ensembl cytogenetic band:  2p11.2   HGNC cytogenetic band: 2p11.2

THNSL2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
THNSL2 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P088469:  view genomic region     (about GC identifiers)

Start:
 88,469,835 bp from pter      End:
 88,486,146 bp from pter
Size:
 16,312 bases      Orientation:
 plus strand

Proteins
for THNSL2 gene

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section
UniProtKB/Swiss-Prot: THNS2_HUMAN, Q86YJ6 (See protein sequence)
Recommended Name: Threonine synthase-like 2  
Size: 484 amino acids; 54116 Da
Cofactor: Pyridoxal phosphate (By similarity)
Subcellular location: Isoform SOLAT: Secreted. Note=Secreted by activated T-cells via a calcineurin-independent
pathway
Sequence caution: Sequence=AAX88906.1; Type=Erroneous gene model prediction; Sequence=BAA91904.1; Type=Erroneous
initiation; Note=Translation N-terminally extended;
Secondary accessions: B3KTB1 B5MDX8 B7WPF8 D9ZZB8 Q6P2M7 Q6PI27 Q9NV54
Alternative splicing: 5 isoforms:  Q86YJ6-1   Q86YJ6-2   Q86YJ6-3   Q86YJ6-4   Q86YJ6-5   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for THNSL2: NX_Q86YJ6

Explore proteomics data for THNSL2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q86YJ6

    • 3 DME Specific Peptides for THNSL2 (Q86YJ6)
     TSGDTGS  AFSRFRHR  PRCCLAPASA 

    THNSL2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    THNSL2 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001231605.1  NP_001231607.1  NP_060741.3  

    ENSEMBL proteins: 
     ENSP00000391300   ENSP00000407553   ENSP00000339563   ENSP00000327323   ENSP00000351402  
     ENSP00000366464   ENSP00000384475  

    Human Recombinant Protein Products for THNSL2: 
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    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for THNSL2 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--
    GO:0005615extracellular space IEA--

    THNSL2 for ontologies           About GeneDecksing



    THNSL2 Antibody Products: 
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    Protein Domains /
    Families
    for THNSL2 gene

    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    		 3 InterPro protein domains:
     IPR004450 Thr_synthase_like
     IPR001926 Trp_syn_b_sub_like_PLP_eny_SF
     IPR027457 TSH2_metazoan

    Graphical View of Domain Structure for InterPro Entry Q86YJ6

    ProtoNet protein and cluster: Q86YJ6

    1 Blocks protein domain: IPB001926 Pyridoxal-5'-phosphate-dependent enzyme

    UniProtKB/Swiss-Prot: THNS2_HUMAN, Q86YJ6
    Similarity: Belongs to the threonine synthase family


    THNSL2 for domains           About GeneDecksing


    Function
    for THNSL2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: THNS2_HUMAN, Q86YJ6
    Function: Isoform 1: Acts as a catabolic phospho-lyase on both gamma- and beta-phosphorylated substrates. Degrades
    O-phospho-threonine (PThr) to alpha-ketobutyrate, ammonia and phosphate (By similarity)
    Function: Isoform SOLAT: Potent inducer of osteoblastic production of IL6. May act to exacerbate inflammation
    and/or bone turnover under inflammatory conditions

         Enzyme Numbers (IUBMB): EC 4.2.3.12 EC 4.2.32 EC 4.2.3.-1

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0005125cytokine activity IEA--
    GO:0016829lyase activity IEA--
    GO:0030170pyridoxal phosphate binding ISS17034760
    GO:0070905serine binding ISS17034760
         
    THNSL2 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for THNSL2:
     Decreased TP53 protein express 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for THNSL2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for THNSL2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for THNSL2 
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    miRNA
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    1 QIAGEN miScript miRNA Assays for microRNA that regulate THNSL2:
    hsa-miR-1911*
    SwitchGear 3'UTR luciferase reporter plasmid: THNSL2 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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                         Customized lentivirus expression plasmids for stable overexpression of THNSL2 

    Cell Line
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    Search LifeMap BioReagents cell lines for THNSL2
    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for THNSL2


    Pathways & Interactions
    for THNSL2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for THNSL2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 17)

    5/174 Interacting proteins for THNSL2 (Q86YJ62, 3 ENSP000003273234) via UniProtKB, MINT, STRING, and/or I2D (see all 174)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ZBTB16Q055162, 3MINT-65640 I2D: score=5 
    ARPC3O151452, 3MINT-63094 I2D: score=4 
    EIF2S1P051983, ENSP000002563834I2D: score=3 STRING: ENSP00000256383
    HMGCS1Q015813, ENSP000003227064I2D: score=3 STRING: ENSP00000322706
    OSGEPQ9NPF43, ENSP000002065424I2D: score=1 STRING: ENSP00000206542
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008150biological_process ND--
    GO:0009071serine family amino acid catabolic process ISS17034760
    GO:0016311dephosphorylation ISS17034760
    GO:00463602-oxobutyrate biosynthetic process ISS17034760

    THNSL2 for ontologies           About GeneDecksing



    Drugs & Compounds
    for THNSL2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for THNSL2 (THNS2)

    1 HMDB Compound for THNSL2    About this table
    CompoundSynonyms CAS #PubMed Ids
    Pyridoxal 5'-phosphateApolon B6 (see all 27)54-47-7--

    Search CenterWatch for drugs/clinical trials and news about THNSL2 / THNS2

    Transcripts
    for THNSL2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for THNSL2 gene (3 alternative transcripts): 
    NM_001244676.1  NM_001244678.1  NM_018271.4  

    Unigene Cluster for THNSL2:

    Threonine synthase-like 2 (S. cerevisiae)
    Hs.740434  [show with all ESTs]
    Unigene Representative Sequence: AK095303
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000419759 ENST00000449349 ENST00000343544(uc002ssw.4) ENST00000324166(uc002ssy.4)
    ENST00000475910(uc021vkq.1) ENST00000496844 ENST00000476349 ENST00000464022
    ENST00000496165 ENST00000358591(uc021vkr.1) ENST00000377254(uc002sta.4 uc010fhe.3)
    ENST00000402102
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    1 QIAGEN miScript miRNA Assays for microRNA that regulate THNSL2:
    hsa-miR-1911*
    SwitchGear 3'UTR luciferase reporter plasmid: THNSL2 3' UTR sequence
    Inhib. RNA
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat THNSL2

    Additional mRNA sequence: 

    AK001778.1 AK095303.1 AK289486.1 AK315831.1 AL832746.1 BC035315.1 BC047758.2 BC050699.2 
    BC064423.1 HM185274.1 

    12 DOTS entries:

    DT.97845078  DT.453751  DT.101984374  DT.97803858  DT.92423625  DT.75146175  DT.120958714  DT.70105426 
    DT.101956831  DT.120958704  DT.100832291  DT.120958703 

    24/140 AceView cDNA sequences (see all 140):

    BE744167 CR613903 CN483939 BU787850 BM924722 CR620866 CD671198 BU752297 
    AI424348 BG481438 CB152560 AA425496 BM450014 BM714547 BU608749 CB157574 
    AI972817 BC035315 AI872402 BF435891 BQ002961 BX348409 BM847548 AU280010 

    GeneLoc Exon Structure

    5/11 Alternative Splicing Database (ASD) splice patterns (SP) for THNSL2 (see all 11)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c · 4d ^ 5a · 5b ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12 ^ 13a ·
    SP1:                          -     -     -                                                     -                                         -     -               
    SP2:                                                                                            -                                         -           -         
    SP3:                                                                                            -                 -     -                 -           -         
    SP4:                                -     -     -                                               -                                                               
    SP5:                                                                                            -                                         -     -     -         

    ExUns: 13b · 13c · 13d
    SP1:                  
    SP2:                  
    SP3:                  
    SP4:                  
    SP5:                  


    ECgene alternative splicing isoforms for THNSL2

    Expression
    for THNSL2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    THNSL2 expression in normal human tissues (normalized intensities)      THNSL2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    THNSL2 Expression
    About this image


    THNSL2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/4 selected tissues (see all 4) fully expand
     
     Uncategorized (Uncategorized)    fully expand to see all 4 entries
             PureStem Progenitor E72
     
     Paraxial Mesoderm (Gastrulation Derivatives)    fully expand to see all 2 entries
             PureStem ES-209, Meso-prx/latp Progenitor
     
     Lateral Plate Mesoderm (Gastrulation Derivatives)    fully expand to see all 2 entries
             PureStem ES-209, Meso-prx/latp Progenitor
     
     Eye (Sensory Organs)
             Human Keratocyte (HK)   

    See THNSL2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for THNSL2

    SOURCE GeneReport for Unigene cluster: Hs.740434
        SABiosciences Custom PCR Arrays for THNSL2
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    In Situ
    Assay Products:     
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    Orthologs
    for THNSL2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals and fungi.

    Orthologs for THNSL2 gene from 5/15 species (see all 15)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Thnsl21 , 5 threonine synthase-like 2 (bacterial)1, 5 84.33(n)1
    83.44(a)1    		   6 (32.14 cM)5
    2320781  NM_178413.41  NP_848500.31 
     711281665 
    chicken
    (Gallus gallus)    		 Aves THNSL21 threonine synthase-like 2 (S. cerevisiae) 69.82(n)
    68.84(a)    		   422927  XM_420866.3  XP_420866.2 
    lizard
    (Anolis carolinensis)    		 Reptilia THNSL26
    		 Uncharacterized protein
    		 65(a)
    		 1 ↔ 1
    		 6(59380111-59400752)
    zebrafish
    (Danio rerio)    		 Actinopterygii thnsl21 threonine synthase-like 2 (S. cerevisiae) 58.53(n)
    53.26(a)    		   641568  NM_001037566.1  NP_001032655.1 
    baker's yeast
    (Saccharomyces cerevisiae)    		 Saccharomycetes THR4(YCR053W)4
    THR41    		 Threonine synthase, conserved protein that catalyzes more4
    Thr4p1    		 48.31(n)1
    40.9(a)1    		   3(216697-218241)4
    8504201, 4  NP_009982.11, 4 


    ENSEMBL Gene Tree for THNSL2 (if available)
    TreeFam Gene Tree for THNSL2 (if available)

    Paralogs
    for THNSL2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for THNSL2 gene
    THNSL12  

    THNSL2 for paralogs           About GeneDecksing



    Genomic Variants
    for THNSL2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/429 SNPs in THNSL2 are shown (see all 429)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 2 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1886126101,2
    		--88467827(+) TGCATA/GGACCC 2 -- us2k10--------
    rs1378905701,2
    		--88467860(+) CTGGAA/GGATCG 2 -- us2k10--------
    rs768303281,2
    		F--88467865(+) AGATCG/ATTGGC 2 -- us2k11Minor allele frequency- A:0.02EA 120
    rs1416134771,2
    		--88467877(+) TCAACA/GTTATA 2 -- us2k10--------
    rs44901851,2
    		C,F,A,H--88467934(+) CGGTTT/GCTAAT 2 -- us2k197Minor allele frequency- G:0.22NS EA PA EU CA WA NA CSA 5180
    rs1926145071,2
    		--88468008(+) CTTCGC/GGATTC 2 -- us2k10--------
    rs1832959421,2
    		--88468131(+) CTGAGA/CGTTTT 2 -- us2k10--------
    rs285149111,2
    		C,F--88468153(+) TTCTGG/AGGAGT 2 -- us2k16Minor allele frequency- A:0.15WA NA CSA 246
    rs1868711391,2
    		--88468261(+) AGAGGA/TCCGTG 2 -- us2k10--------
    rs1176254921,2
    		F--88468263(+) AGGTCC/TGTGGA 2 -- us2k11Minor allele frequency- T:0.01EA 120

    HapMap Linkage Disequilibrium report for THNSL2 (88469835 - 88486146 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for THNSL2:    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv61n16CNV Deletion17901297
    esv1593020CNV Insertion17803354
    esv1550357CNV Insertion17803354
    nsv507021CNV Insertion20534489
    esv2518093CNV Insertion19546169
    nsv874581CNV Gain21882294
    nsv834289CNV Gain17160897

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    Disorders / Diseases
    for THNSL2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    		 OMIM gene information: 611261    OMIM disorders: --

    2 diseases for THNSL2:    About MalaCards
    pneumonia    


    THNSL2 for disorders           About GeneDecksing


    Export disorders for THNSL2 gene to outside databases

    Publications
    for THNSL2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for THNSL2 gene, integrated from 9 sources (see all 11):
    (articles sorted by number of sources associating them with THNSL2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel T cell cytokine, secreted osteoclastogenic fa ctor of activated T cells, induces osteoclast formation in a RANKL-independent manner. (PubMed id 19877052)1, 2 Rifas L. and Weitzmann M.N. (2009)
    2. A threonine synthase homolog from a mammalian genome. (PubMed id 17034760)1, 3 Donini S....Peracchi A. (2006)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women. (PubMed id 22589738)1 Fox C.S....Borecki I.B. (2012)
    5. Bimodal distribution of RNA expression levels in huma n skeletal muscle tissue. (PubMed id 21299892)1 Mason C.C....Bogardus C. (2011)
    6. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
    7. Genome-wide prediction of mammalian enhancers based on analysis of transcription-factor binding affinity. (PubMed id 16413481)1 Hallikas O....Taipale J. (2006)
    8. A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070)1 Stelzl U.... Wanker E.E. (2005)
    9. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)2 Hillier L.W....Wilson R.K. (2005)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)

    External Searches for THNSL2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing THNSL2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 55258 HGNC: 25602 AceView: FLJ10916 Ensembl:ENSG00000144115 euGenes: HUgn55258
    ECgene: THNSL2 H-InvDB: THNSL2

    Other Databases showing THNSL2 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing THNSL2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for THNSL2 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for THNSL2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for THNSL2 gene:
    Search GeneIP for patents involving THNSL2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

     
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