Aliases for THNSL2 Gene
External Ids for THNSL2 Gene
Previous GeneCards Identifiers for THNSL2 Gene
This gene encodes a threonine synthase-like protein. A similar enzyme in mouse can catalyze the degradation of O-phospho-homoserine to a-ketobutyrate, phosphate, and ammonia. This protein also has phospho-lyase activity on both gamma and beta phosphorylated substrates. In mouse an alternatively spliced form of this protein has been shown to act as a cytokine and can induce the production of the inflammatory cytokine IL6 in osteoblasts. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2011]
GeneCards Summary for THNSL2 Gene
THNSL2 (Threonine Synthase Like 2) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include cytokine activity and lyase activity. An important paralog of this gene is THNSL1.
UniProtKB/Swiss-Prot for THNSL2 Gene
Isoform 1: Acts as a catabolic phospho-lyase on both gamma- and beta-phosphorylated substrates. Degrades O-phospho-threonine (PThr) to alpha-ketobutyrate, ammonia and phosphate (By similarity).
Isoform SOFAT: Potent inducer of osteoblastic production of IL6. May act to exacerbate inflammation and/or bone turnover under inflammatory conditions.