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THNSL2 Gene

protein-coding   GIFtS: 50
GCID: GC02P088469

Threonine Synthase-Like 2 (S. Cerevisiae)

  Search for THNSL2
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Threonine Synthase-Like 2 (S. Cerevisiae)1 2     Threonine Synthase-Like 22
SOFAT2 3     EC 4.2.3.-3
TSH22 3     Secreted Osteoclastogenic Factor Of Activated T-Cells3
THS22 5     EC 4.2.38
Secreted Osteoclastogenic Factor Of Activated T Cells2     EC 4.2.3.18

External Ids:    HGNC: 256021   Entrez Gene: 552582   Ensembl: ENSG000001441157   OMIM: 6112615   UniProtKB: Q86YJ63   

Export aliases for THNSL2 gene to outside databases

Previous GC identifers: GC02P088251 GC02P087392


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for THNSL2 Gene:
This gene encodes a threonine synthase-like protein. A similar enzyme in mouse can catalyze the degradation of
O-phospho-homoserine to a-ketobutyrate, phosphate, and ammonia. This protein also has phospho-lyase activity on
both gamma and beta phosphorylated substrates. In mouse an alternatively spliced form of this protein has been
shown to act as a cytokine and can induce the production of the inflammatory cytokine IL6 in osteoblasts.
Alternate splicing results in multiple transcript variants. (provided by RefSeq, Sep 2011)

GeneCards Summary for THNSL2 Gene:
THNSL2 (threonine synthase-like 2 (S. cerevisiae)) is a protein-coding gene. GO annotations related to this gene include lyase activity and cytokine activity. An important paralog of this gene is THNSL1.

UniProtKB/Swiss-Prot: THNS2_HUMAN, Q86YJ6
Function: Isoform 1: Acts as a catabolic phospho-lyase on both gamma- and beta-phosphorylated substrates. Degrades
O-phospho-threonine (PThr) to alpha-ketobutyrate, ammonia and phosphate (By similarity)
Function: Isoform SOLAT: Potent inducer of osteoblastic production of IL6. May act to exacerbate inflammation
and/or bone turnover under inflammatory conditions




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the THNSL2 gene promoter:
         Nkx3-1   AhR   Nkx3-1 v4   AML1a   Nkx3-1 v1   Arnt   Nkx3-1 v2   COMP1   Nkx3-1 v3   c-Myb   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTHNSL2 promoter sequence
   Search Chromatin IP Primers for THNSL2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat THNSL2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p11.2   Ensembl cytogenetic band:  2p11.2   HGNC cytogenetic band: 2p11.2

THNSL2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
THNSL2 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P088469:  view genomic region     (about GC identifiers)

Start:
88,469,835 bp from pter      End:
88,486,146 bp from pter
Size:
16,312 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: THNS2_HUMAN, Q86YJ6 (See protein sequence)
Recommended Name: Threonine synthase-like 2  
Size: 484 amino acids; 54116 Da
Cofactor: Pyridoxal phosphate (By similarity)
Sequence caution: Sequence=AAX88906.1; Type=Erroneous gene model prediction; Sequence=BAA91904.1; Type=Erroneous
initiation; Note=Translation N-terminally extended;
Secondary accessions: B3KTB1 B5MDX8 B7WPF8 D9ZZB8 Q6P2M7 Q6PI27 Q9NV54
Alternative splicing: 5 isoforms:  Q86YJ6-1   Q86YJ6-2   Q86YJ6-3   Q86YJ6-4   Q86YJ6-5   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for THNSL2: NX_Q86YJ6

Explore proteomics data for THNSL2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • 3 DME Specific Peptides for THNSL2 (Q86YJ6)
     TSGDTGS  AFSRFRHR  PRCCLAPASA 


    See THNSL2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001231605.1  NP_001231607.1  NP_060741.3  

    ENSEMBL proteins: 
     ENSP00000391300   ENSP00000407553   ENSP00000339563   ENSP00000327323   ENSP00000351402  
     ENSP00000366464   ENSP00000384475  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR004450 Thr_synthase_like
     IPR001926 Trp_syn_b_sub_like_PLP_eny_SF
     IPR027457 TSH2_metazoan

    Graphical View of Domain Structure for InterPro Entry Q86YJ6

    ProtoNet protein and cluster: Q86YJ6

    1 Blocks protein domain: IPB001926 Pyridoxal-5'-phosphate-dependent enzyme

    UniProtKB/Swiss-Prot: THNS2_HUMAN, Q86YJ6
    Similarity: Belongs to the threonine synthase family


    Find genes that share domains with THNSL2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: THNS2_HUMAN, Q86YJ6
    Function: Isoform 1: Acts as a catabolic phospho-lyase on both gamma- and beta-phosphorylated substrates. Degrades
    O-phospho-threonine (PThr) to alpha-ketobutyrate, ammonia and phosphate (By similarity)
    Function: Isoform SOLAT: Potent inducer of osteoblastic production of IL6. May act to exacerbate inflammation
    and/or bone turnover under inflammatory conditions

         Enzyme Numbers (IUBMB): EC 4.2.3.12 EC 4.2.32 EC 4.2.3.-1

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0005125cytokine activity IEA--
    GO:0016829lyase activity IEA--
    GO:0030170pyridoxal phosphate binding ISS17034760
    GO:0070905serine binding ISS17034760
         
    Find genes that share ontologies with THNSL2           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for THNSL2:
     Decreased TP53 protein express 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for THNSL2
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    1 qRT-PCR Assays for microRNA that regulate THNSL2:
    hsa-miR-1911*
    SwitchGear 3'UTR luciferase reporter plasmidTHNSL2 3' UTR sequence
    Inhib. RNA
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    Browse Sino Biological Human cDNA Clones
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    THNS2_HUMAN, Q86YJ6: Isoform SOLAT: Secreted. Note=Secreted by activated T-cells via a calcineurin-independent
    pathway
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    cytosol2
    mitochondrion2
    nucleus1
    peroxisome1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--
    GO:0005615extracellular space IEA--

    Find genes that share ontologies with THNSL2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for THNSL2
    Interactions:

        Search GeneGlobe Interaction Network for THNSL2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 21)

    Selected Interacting proteins for THNSL2 (Q86YJ62, 3 ENSP000003273234) via UniProtKB, MINT, STRING, and/or I2D (see all 185)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ZBTB16Q055162, 3MINT-65640 I2D: score=5 
    ARPC3O151452, 3MINT-63094 I2D: score=4 
    OSGEPQ9NPF43, ENSP000002065424I2D: score=1 STRING: ENSP00000206542
    PSAT1Q9Y6173, ENSP000003657734I2D: score=1 STRING: ENSP00000365773
    XPOTO435923, ENSP000003278214I2D: score=1 STRING: ENSP00000327821
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008150biological_process ND--
    GO:0009071serine family amino acid catabolic process ISS17034760
    GO:0016311dephosphorylation ISS17034760
    GO:00463602-oxobutyrate biosynthetic process ISS17034760

    Find genes that share ontologies with THNSL2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for THNSL2 (THNS2)

    1 HMDB Compound for THNSL2    About this table
    CompoundSynonyms CAS #PubMed Ids
    Pyridoxal 5'-phosphateApolon B6 (see all 27)54-47-7--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for THNSL2 gene (3 alternative transcripts): 
    NM_001244676.1  NM_001244678.1  NM_018271.4  

    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000419759 ENST00000449349 ENST00000343544(uc002ssw.4) ENST00000324166(uc002ssy.4)
    ENST00000475910(uc021vkq.1) ENST00000496844 ENST00000476349 ENST00000464022
    ENST00000496165 ENST00000358591(uc021vkr.1) ENST00000377254(uc002sta.4 uc010fhe.3)
    ENST00000402102
    miRNA
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    1 qRT-PCR Assays for microRNA that regulate THNSL2:
    hsa-miR-1911*
    SwitchGear 3'UTR luciferase reporter plasmidTHNSL2 3' UTR sequence
    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat THNSL2
      QuantiFast Probe-based Assays in human, mouse, rat THNSL2

    Selected AceView cDNA sequences (see all 140):

    AA425496 AI424348 CB152560 CR620866 BG481438 BM924722 BC035315 BU787850 
    BU752297 AI972817 CD671198 CR613903 BU608749 BE744167 CB157574 BM714547 
    BM450014 CN483939 BM847548 AU280010 BM698859 AU133626 BF435891 BM920194 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for THNSL2 (see all 11)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c · 4d ^ 5a · 5b ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12 ^ 13a ·
    SP1:                          -     -     -                                                     -                                         -     -               
    SP2:                                                                                            -                                         -           -         
    SP3:                                                                                            -                 -     -                 -           -         
    SP4:                                -     -     -                                               -                                                               
    SP5:                                                                                            -                                         -     -     -         

    ExUns: 13b · 13c · 13d
    SP1:                  
    SP2:                  
    SP3:                  
    SP4:                  
    SP5:                  


    ECgene alternative splicing isoforms for THNSL2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    THNSL2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    THNSL2 Expression
    About this image


    THNSL2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Paraxial Mesoderm (Gastrulation Derivatives)
             PureStem E15, Meso-prx/latp Progenitor
     
     Lateral Plate Mesoderm (Gastrulation Derivatives)
             PureStem E15, Meso-prx/latp Progenitor
    THNSL2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    THNSL2 Protein Expression
        Custom PCR Arrays for THNSL2
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for THNSL2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for THNSL2 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Thnsl21 , 5 threonine synthase-like 2 (bacterial)1, 5 84.33(n)1
    83.44(a)1
      6 (32.14 cM)5
    2320781  NM_001033929.21  NP_001029101.11 
     711281665 
    chicken
    (Gallus gallus)
    Aves THNSL21 threonine synthase-like 2 (S. cerevisiae) 69.75(n)
    68.63(a)
      422927  XM_004936267.1  XP_004936324.1 
    lizard
    (Anolis carolinensis)
    Reptilia THNSL26
    threonine synthase-like 2 (S. cerevisiae)
    66(a)
    1 ↔ 1
    6(59380111-59400752)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia thnsl21 threonine synthase-like 2 64.47(n)
    60.93(a)
      100127762  XM_002937275.2  XP_002937321.1 
    zebrafish
    (Danio rerio)
    Actinopterygii thnsl21 threonine synthase-like 2 (S. cerevisiae) 58.53(n)
    53.26(a)
      641568  NM_001037566.1  NP_001032655.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes THR4(YCR053W)4
    THR41
    Threonine synthase, conserved protein that catalyzes more4
    THR41
    47.8(n)1
    39.31(a)1
      3(216697-218241)4
    8504201, 4  NP_009982.11, 4 


    ENSEMBL Gene Tree for THNSL2 (if available)
    TreeFam Gene Tree for THNSL2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for THNSL2 gene
    THNSL12  

    Find genes that share paralogs with THNSL2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for THNSL2 (see all 429)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1886126101,2
    --88467827(+) TGCATA/GGACCC 2 -- us2k10--------
    rs1378905701,2
    --88467860(+) CTGGAA/GGATCG 2 -- us2k10--------
    rs768303281,2
    F--88467865(+) AGATCG/ATTGGC 2 -- us2k11Minor allele frequency- A:0.02EA 120
    rs1416134771,2
    --88467877(+) TCAACA/GTTATA 2 -- us2k10--------
    rs44901851,2
    C,F,A,H--88467934(+) CGGTTT/GCTAAT 2 -- us2k197Minor allele frequency- G:0.22NS EA PA EU CA WA NA CSA 5180
    rs1926145071,2
    --88468008(+) CTTCGC/GGATTC 2 -- us2k10--------
    rs1832959421,2
    --88468131(+) CTGAGA/CGTTTT 2 -- us2k10--------
    rs285149111,2
    C,F--88468153(+) TTCTGG/AGGAGT 2 -- us2k16Minor allele frequency- A:0.15WA NA CSA 246
    rs1868711391,2
    --88468261(+) AGAGGA/TCCGTG 2 -- us2k10--------
    rs1176254921,2
    F--88468263(+) AGGTCC/TGTGGA 2 -- us2k11Minor allele frequency- T:0.01EA 120

    HapMap Linkage Disequilibrium report for THNSL2 (88469835 - 88486146 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for THNSL2:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv61n16CNV Deletion17901297
    esv1593020CNV Insertion17803354
    esv1550357CNV Insertion17803354
    nsv507021CNV Insertion20534489
    esv2518093CNV Insertion19546169
    nsv874581CNV Gain21882294
    nsv834289CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 611261    OMIM disorders: --


    Find genes that share disorders with THNSL2           About GenesLikeMe


    Export disorders for THNSL2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for THNSL2 gene, integrated from 10 sources (see all 13):
    (articles sorted by number of sources associating them with THNSL2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel T cell cytokine, secreted osteoclastogenic factor of activated T cells, induces osteoclast formation in a RANKL-independent manner. (PubMed id 19877052)1, 2 Rifas L. and Weitzmann M.N. (Arthritis Rheum. 2009)
    2. A threonine synthase homolog from a mammalian genome. (PubMed id 17034760)1, 3 Donini S....Peracchi A. (Biochem. Biophys. Res. Commun. 2006)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. Secreted osteoclastogenic factor of activated T cells (SOFAT), a novel osteoclast activator, in chronic periodontitis. (PubMed id 23619471)1 Jarry C.R....Napimoga M.H. (Hum. Immunol. 2013)
    5. Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women. (PubMed id 22589738)1 Fox C.S....Borecki I.B. (PLoS Genet. 2012)
    6. Bimodal distribution of RNA expression levels in human skeletal muscle tissue. (PubMed id 21299892)1 Mason C.C....Bogardus C. (BMC Genomics 2011)
    7. Genome-scale RNAi screen for host factors required for HIV replication. (PubMed id 18976975)1 Zhou H....Espeseth A.S. (amp 2008)
    8. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
    9. Genome-wide prediction of mammalian enhancers based on analysis of transcription-factor binding affinity. (PubMed id 16413481)1 Hallikas O....Taipale J. (Cell 2006)
    10. A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070)1 Stelzl U.... Wanker E.E. (Cell 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 55258 HGNC: 25602 AceView: FLJ10916 Ensembl:ENSG00000144115 euGenes: HUgn55258
    ECgene: THNSL2 H-InvDB: THNSL2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for THNSL2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for THNSL2 gene:
    Search GeneIP for patents involving THNSL2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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