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THNSL2 Gene

protein-coding GIFtS: 50
GCID: GC02P088469

Threonine Synthase-Like 2 (S. Cerevisiae)

Microbiology & Infectious Diseases Congress

See related disease
at

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(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Aliases
Threonine Synthase-Like 2 (S. Cerevisiae)¹ ²		Threonine Synthase-Like 2²
SOFAT² ³		EC 4.2.3.-³
TSH2² ³		Secreted Osteoclastogenic Factor Of Activated T-Cells³
THS2² ⁵		EC 4.2.3⁸
Secreted Osteoclastogenic Factor Of Activated T Cells²		EC 4.2.3.1⁸

External Ids:	HGNC: 25602¹	Entrez Gene: 55258²	Ensembl: ENSG00000144115⁷	OMIM: 611261⁵	UniProtKB: Q86YJ6³

Export aliases for THNSL2 gene to outside databases

Previous GC identifers: GC02P088251 GC02P087392

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for THNSL2 Gene:

This gene encodes a threonine synthase-like protein. A similar enzyme in mouse can catalyze the degradation of

O-phospho-homoserine to a-ketobutyrate, phosphate, and ammonia. This protein also has phospho-lyase activity on

both gamma and beta phosphorylated substrates. In mouse an alternatively spliced form of this protein has been

shown to act as a cytokine and can induce the production of the inflammatory cytokine IL6 in osteoblasts.

Alternate splicing results in multiple transcript variants. (provided by RefSeq, Sep 2011)

GeneCards Summary for THNSL2 Gene:

THNSL2 (threonine synthase-like 2 (S. cerevisiae)) is a protein-coding gene. Diseases associated with THNSL2 include pneumonia. GO annotations related to this gene include lyase activity and cytokine activity. An important paralog of this gene is THNSL1.

UniProtKB/Swiss-Prot: THNS2_HUMAN, Q86YJ6

Function: Isoform 1: Acts as a catabolic phospho-lyase on both gamma- and beta-phosphorylated substrates. Degrades

O-phospho-threonine (PThr) to alpha-ketobutyrate, ammonia and phosphate (By similarity)

Function: Isoform SOLAT: Potent inducer of osteoblastic production of IL6. May act to exacerbate inflammation

and/or bone turnover under inflammatory conditions

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:

Regulatory transcription factor binding sites in the THNSL2 gene promoter:
Nkx3-1 AhR Nkx3-1 v4 AML1a Nkx3-1 v1 Arnt Nkx3-1 v2 COMP1 Nkx3-1 v3 c-Myb
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: THNSL2 promoter sequence

Search Chromatin IP Primers for THNSL2

Epigenetics:

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat THNSL2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p11.2 Ensembl cytogenetic band: 2p11.2 HGNC cytogenetic band: 2p11.2

THNSL2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
THNSL2 gene location

GeneLoc information about chromosome 2 GeneLoc Exon Structure

GeneLoc location for GC02P088469: view genomic region (about GC identifiers)

Start:	88,469,835 bp from pter	End:	88,486,146 bp from pter
Size:	16,312 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: THNS2_HUMAN, Q86YJ6 (See protein sequence)

Recommended Name: Threonine synthase-like 2

Size: 484 amino acids; 54116 Da

Cofactor: Pyridoxal phosphate (By similarity)

Sequence caution: Sequence=AAX88906.1; Type=Erroneous gene model prediction; Sequence=BAA91904.1; Type=Erroneous

initiation; Note=Translation N-terminally extended;

Secondary accessions: B3KTB1 B5MDX8 B7WPF8 D9ZZB8 Q6P2M7 Q6PI27 Q9NV54

Alternative splicing: 5 isoforms: Q86YJ6-1 Q86YJ6-2 Q86YJ6-3 Q86YJ6-4 Q86YJ6-5 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for THNSL2: NX_Q86YJ6

Explore proteomics data for THNSL2 at MOPED

Post-translational modifications:

Modification sites at neXtProt

Modification sites at PhosphoSitePlus

3 DME Specific Peptides for THNSL2 (Q86YJ6)

TSGDTGS

AFSRFRHR

PRCCLAPASA

See THNSL2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins (3 alternative transcripts):

NP_001231605.1 NP_001231607.1 NP_060741.3

ENSEMBL proteins:

ENSP00000391300 ENSP00000407553 ENSP00000339563 ENSP00000327323 ENSP00000351402

ENSP00000366464 ENSP00000384475

THNSL2 Human Recombinant Protein Products:

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	GenScript Custom Purified and Recombinant Proteins Services for THNSL2
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THNSL2 Antibody Products:

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	LSBio Antibodies in human, mouse, rat for THNSL2

THNSL2 Assay Products:

	Browse Kits and Assays available from EMD Millipore
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	GenScript Custom Assay Services for THNSL2
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	Cloud-Clone Corp. ELISAs for THNSL2 Cloud-Clone Corp. CLIAs for THNSL2

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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3 InterPro protein domains:

IPR004450 Thr_synthase_like

IPR001926 Trp_syn_b_sub_like_PLP_eny_SF

IPR027457 TSH2_metazoan

Graphical View of Domain Structure for InterPro Entry Q86YJ6

ProtoNet protein and cluster: Q86YJ6

1 Blocks protein domain: IPB001926 Pyridoxal-5'-phosphate-dependent enzyme

UniProtKB/Swiss-Prot: THNS2_HUMAN, Q86YJ6

Similarity: Belongs to the threonine synthase family

THNSL2 for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

UniProtKB/Swiss-Prot Summary: THNS2_HUMAN, Q86YJ6

Function: Isoform 1: Acts as a catabolic phospho-lyase on both gamma- and beta-phosphorylated substrates. Degrades

O-phospho-threonine (PThr) to alpha-ketobutyrate, ammonia and phosphate (By similarity)

Function: Isoform SOLAT: Potent inducer of osteoblastic production of IL6. May act to exacerbate inflammation

and/or bone turnover under inflammatory conditions

Enzyme Numbers (IUBMB): EC 4.2.3.1² EC 4.2.3² EC 4.2.3.-¹

Gene Ontology (GO): 5 molecular function terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003674	molecular_function	ND	--
GO:0005125	cytokine activity	IEA	--
GO:0016829	lyase activity	IEA	--
GO:0030170	pyridoxal phosphate binding	ISS	17034760
GO:0070905	serine binding	ISS	17034760

THNSL2 for ontologies About GeneDecksing

Phenotypes:
1 GenomeRNAi human phenotype for THNSL2:

Decreased TP53 protein express

Animal Models:

inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for THNSL2

inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for THNSL2

genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for THNSL2

genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for THNSL2

miRNA Products:		Block miRNA regulation of human, mouse, rat THNSL2 using miScript Target Protectors
		1 qRT-PCR Assays for microRNA that regulate THNSL2:
		hsa-miR-1911*
		SwitchGear 3'UTR luciferase reporter plasmid: THNSL2 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for THNSL2
		Predesigned siRNA for gene silencing in human, mouse, rat THNSL2

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for THNSL2

Clone Products:		OriGene clones in human, mouse for THNSL2 (see all 8) OriGene ORF clones in mouse, rat for THNSL2 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: THNSL2 (NM_018271)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for THNSL2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat THNSL2

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for THNSL2
		Browse ESI BIO Cell Lines and PureStem Progenitors for THNSL2

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for THNSL2

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot

THNS2_HUMAN, Q86YJ6: Isoform SOLAT: Secreted. Note=Secreted by activated T-cells via a calcineurin-independent

pathway

Subcellular locations from COMPARTMENTS:

Compartment	Confidence
extracellular	5
cytosol	2
mitochondrion	2
nucleus	1
peroxisome	1

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Gene Ontology (GO): 2 cellular component terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005575	cellular_component	ND	--
GO:0005615	extracellular space	IEA	--

THNSL2 for ontologies About GeneDecksing

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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Custom Pathway & Disease-focused RT² Profiler PCR Arrays for THNSL2
Interactions:

Search GeneGlobe Interaction Network for THNSL2

STRING Interaction Network Preview (showing 5 interactants - click image to see 21)

Selected Interacting proteins for THNSL2 (Q86YJ6^{2, 3} ENSP00000327323⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 185)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ZBTB16	Q05516²^,³	MINT-65640 I2D: score=5
ARPC3	O15145²^,³	MINT-63094 I2D: score=4
OSGEP	Q9NPF4³, ENSP00000206542⁴	I2D: score=1 STRING: ENSP00000206542
PSAT1	Q9Y617³, ENSP00000365773⁴	I2D: score=1 STRING: ENSP00000365773
XPOT	O43592³, ENSP00000327821⁴	I2D: score=1 STRING: ENSP00000327821

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Gene Ontology (GO): 4 biological process terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0008150	biological_process	ND	--
GO:0009071	serine family amino acid catabolic process	ISS	17034760
GO:0016311	dephosphorylation	ISS	17034760
GO:0046360	2-oxobutyrate biosynthetic process	ISS	17034760

THNSL2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse compounds at ApexBio

Browse Tocris compounds for THNSL2 (THNS2)

1 HMDB Compound for THNSL2 About this table

Compound	Synonyms	CAS #	PubMed Ids
Pyridoxal 5'-phosphate	Apolon B6 (see all 27)	54-47-7	--

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for THNSL2 gene (3 alternative transcripts):

NM_001244676.1 NM_001244678.1 NM_018271.4

12 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000419759 ENST00000449349 ENST00000343544(uc002ssw.4) ENST00000324166(uc002ssy.4)

ENST00000475910(uc021vkq.1) ENST00000496844 ENST00000476349 ENST00000464022

ENST00000496165 ENST00000358591(uc021vkr.1) ENST00000377254(uc002sta.4 uc010fhe.3)

ENST00000402102

Congresses - knowledge worth sharing:
European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

miRNA Products:		Block miRNA regulation of human, mouse, rat THNSL2 using miScript Target Protectors
		1 qRT-PCR Assays for microRNA that regulate THNSL2:
		hsa-miR-1911*
		SwitchGear 3'UTR luciferase reporter plasmid: THNSL2 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for THNSL2
		Predesigned siRNA for gene silencing in human, mouse, rat THNSL2

Clone Products:		OriGene clones in human, mouse for THNSL2 (see all 8) OriGene ORF clones in mouse, rat for THNSL2 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: THNSL2 (NM_018271)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for THNSL2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat THNSL2

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		QuantiTect SYBR Green Assays in human, mouse, rat THNSL2
		QuantiFast Probe-based Assays in human, mouse, rat THNSL2

Selected AceView cDNA sequences (see all 140):

AA425496 AI424348 CB152560 CR620866 BG481438 BM924722 BC035315 BU787850

BU752297 AI972817 CD671198 CR613903 BU608749 BE744167 CB157574 BM714547

BM450014 CN483939 BM847548 AU280010 BM698859 AU133626 BF435891 BM920194

GeneLoc Exon Structure

Selected Alternative Splicing Database (ASD) splice patterns (SP) for THNSL2 (see all 11) About this scheme

ExUns:	1a	·	1b	·	1c	·	1d	^	2	^	3a	·	3b	^	4a	·	4b	·	4c	·	4d	^	5a	·	5b	^	6a	·	6b	·	6c	^	7	^	8a	·	8b	^	9a	·	9b	^	10a	·	10b	^	11	^	12	^	13a	·
SP1:									-		-		-																		-														-		-
SP2:																															-														-				-
SP3:																															-						-		-						-				-
SP4:											-		-		-																-
SP5:																															-														-		-		-

ExUns:	13b	·	13c	·	13d
SP1:
SP2:
SP3:
SP4:
SP5:

ECgene alternative splicing isoforms for THNSL2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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THNSL2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: --

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THNSL2 expression in embryonic tissues and stem cells About this table

Data from LifeMap, the Embryonic Development and Stem Cells Database
selected tissues (see all 2) fully expand


Paraxial Mesoderm (Gastrulation Derivatives)
PureStem E15, Meso-prx/latp Progenitor

Lateral Plate Mesoderm (Gastrulation Derivatives)
PureStem E15, Meso-prx/latp Progenitor

THNSL2 Protein expression data from MOPED¹, PaxDb² and MaxQB³:

About this image

THNSL2 Protein Expression

Custom PCR Arrays for THNSL2

Primer Products:		OriGene qSTAR qPCR primer pairs in human, mouse for THNSL2
		Pre-validated RT² qPCR Primer Assay in human, mouse, rat THNSL2
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		QuantiFast Probe-based Assays in human, mouse, rat THNSL2

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for THNSL2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals and fungi.

Orthologs for THNSL2 gene from Selected species (see all 16) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Thnsl2^{1 , 5}	threonine synthase-like 2 (bacterial)^{1, 5}	84.33(n)¹ 83.44(a)¹		6 (32.14 cM)⁵ 232078¹ NM_001033929.2¹ NP_001029101.1¹ 71128166⁵
chicken (Gallus gallus)	Aves	THNSL2¹	threonine synthase-like 2 (S. cerevisiae)	69.75(n) 68.63(a)		422927 XM_004936267.1 XP_004936324.1
lizard (Anolis carolinensis)	Reptilia	THNSL2⁶	threonine synthase-like 2 (S. cerevisiae)	66(a)	1 ↔ 1	6(59380111-59400752)
tropical clawed frog (Xenopus tropicalis)	Amphibia	thnsl2¹	threonine synthase-like 2	64.47(n) 60.93(a)		100127762 XM_002937275.2 XP_002937321.1
zebrafish (Danio rerio)	Actinopterygii	thnsl2¹	threonine synthase-like 2 (S. cerevisiae)	58.53(n) 53.26(a)		641568 NM_001037566.1 NP_001032655.1
baker's yeast (Saccharomyces cerevisiae)	Saccharomycetes	THR4(YCR053W)⁴ THR4¹	Threonine synthase, conserved protein that catalyzes more⁴ THR4¹	47.8(n)¹ 39.31(a)¹		3(216697-218241)⁴ 850420^{1, 4} NP_009982.1^{1, 4}

ENSEMBL Gene Tree for THNSL2 (if available)
TreeFam Gene Tree for THNSL2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for THNSL2 gene

THNSL1²

THNSL2 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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SNP ID	Valid	Clinical significance	Chr 2 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs188612610^1,2		--	88467827(+)	`TGCATA/GGACCC`	2	--	us2k¹		0	--	--	--	--
rs137890570^1,2		--	88467860(+)	`CTGGAA/GGATCG`	2	--	us2k¹		0	--	--	--	--
rs76830328^1,2	F	--	88467865(+)	`AGATCG/ATTGGC`	2	--	us2k¹		1		EA	120
rs141613477^1,2		--	88467877(+)	`TCAACA/GTTATA`	2	--	us2k¹		0	--	--	--	--
rs4490185^1,2	C,F,A,H	--	88467934(+)	`CGGTTT/GCTAAT`	2	--	us2k¹		97		NS EA PA EU CA WA NA CSA	5180
rs192614507^1,2		--	88468008(+)	`CTTCGC/GGATTC`	2	--	us2k¹		0	--	--	--	--
rs183295942^1,2		--	88468131(+)	`CTGAGA/CGTTTT`	2	--	us2k¹		0	--	--	--	--
rs28514911^1,2	C,F	--	88468153(+)	`TTCTGG/AGGAGT`	2	--	us2k¹		6		WA NA CSA	246
rs186871139^1,2		--	88468261(+)	`AGAGGA/TCCGTG`	2	--	us2k¹		0	--	--	--	--
rs117625492^1,2	F	--	88468263(+)	`AGGTCC/TGTGGA`	2	--	us2k¹		1		EA	120

HapMap Linkage Disequilibrium report for THNSL2 (88469835 - 88486146 bp)

Structural Variations
Database of Genomic Variants (DGV) 7 variations for THNSL2: About this table

Variant ID	Type	Subtype	PubMed ID
dgv61n16	CNV	Deletion	17901297
esv1593020	CNV	Insertion	17803354
esv1550357	CNV	Insertion	17803354
nsv507021	CNV	Insertion	20534489
esv2518093	CNV	Insertion	19546169
nsv874581	CNV	Gain	21882294
nsv834289	CNV	Gain	17160897

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing THNSL2

DNA2.0 Custom Variant and Variant Library Synthesis for THNSL2

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 611261 OMIM disorders: --

1 disease for THNSL2:
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pneumonia

THNSL2 for disorders About GeneDecksing

Export disorders for THNSL2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for THNSL2 gene, integrated from 10 sources (see all 13):
(articles sorted by number of sources associating them with THNSL2)

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A novel T cell cytokine, secreted osteoclastogenic factor of activated T cells, induces osteoclast formation in a RANKL-independent manner. (PubMed id 19877052)^{1, 2} Rifas L. and Weitzmann M.N. (Arthritis Rheum. 2009)
A threonine synthase homolog from a mammalian genome. (PubMed id 17034760)^{1, 3} Donini S....Peracchi A. (Biochem. Biophys. Res. Commun. 2006)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (Nat. Genet. 2004)
Secreted osteoclastogenic factor of activated T cells (SOFAT), a novel osteoclast activator, in chronic periodontitis. (PubMed id 23619471)¹ Jarry C.R....Napimoga M.H. (Hum. Immunol. 2013)
Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women. (PubMed id 22589738)¹ Fox C.S....Borecki I.B. (PLoS Genet. 2012)
Bimodal distribution of RNA expression levels in human skeletal muscle tissue. (PubMed id 21299892)¹ Mason C.C....Bogardus C. (BMC Genomics 2011)
Genome-scale RNAi screen for host factors required for HIV replication. (PubMed id 18976975)¹ Zhou H....Espeseth A.S. (amp 2008)
Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)¹ Kimura K.... Sugano S. (Genome Res. 2006)
Genome-wide prediction of mammalian enhancers based on analysis of transcription-factor binding affinity. (PubMed id 16413481)¹ Hallikas O....Taipale J. (Cell 2006)
A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070)¹ Stelzl U.... Wanker E.E. (Cell 2005)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 55258	HGNC: 25602	AceView: FLJ10916	Ensembl:ENSG00000144115	euGenes: HUgn55258
ECgene: THNSL2	H-InvDB: THNSL2

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for THNSL2	Pharmacogenomics, SNPs, Pathways

Intellectual Property for THNSL2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for THNSL2 gene:
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THNSL2 Gene

Threonine Synthase-Like 2 (S. Cerevisiae)

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THNSL2 Gene

Threonine Synthase-Like 2 (S. Cerevisiae)

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