Aliases for THNSL2 Gene
Aliases for THNSL2 Gene
External Ids for THNSL2 Gene
- HGNC: 25602
- Entrez Gene: 55258
- Ensembl: ENSG00000144115
- OMIM: 611261
- UniProtKB: Q86YJ6
Previous GeneCards Identifiers for THNSL2 Gene
- GC02P088251
- GC02P088469
- GC02P087392
Summaries for THNSL2 Gene
-
This gene encodes a threonine synthase-like protein. A similar enzyme in mouse can catalyze the degradation of O-phospho-homoserine to a-ketobutyrate, phosphate, and ammonia. This protein also has phospho-lyase activity on both gamma and beta phosphorylated substrates. In mouse an alternatively spliced form of this protein has been shown to act as a cytokine and can induce the production of the inflammatory cytokine IL6 in osteoblasts. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2011]
GeneCards Summary for THNSL2 Gene
THNSL2 (Threonine Synthase Like 2) is a Protein Coding gene. GO annotations related to this gene include cytokine activity and lyase activity. An important paralog of this gene is THNSL1.
UniProtKB/Swiss-Prot for THNSL2 Gene
-
Isoform 1: Acts as a catabolic phospho-lyase on both gamma- and beta-phosphorylated substrates. Degrades O-phospho-threonine (PThr) to alpha-ketobutyrate, ammonia and phosphate (By similarity).
-
Isoform SOFAT: Potent inducer of osteoblastic production of IL6. May act to exacerbate inflammation and/or bone turnover under inflammatory conditions.
No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for THNSL2 Gene
Genomics for THNSL2 Gene
Regulatory Elements for THNSL2 Gene
Enhancers for THNSL2 Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH02G088160 | 1.2 | ENCODE dbSUPER | 82.5 | -10.2 | -10219 | 0.2 | ELF3 WRNIP1 ARID4B DMAP1 ZSCAN9 RAD21 RARA YY1 SLC30A9 ZNF143 | THNSL2 FABP1 GC02P088146 |
| GH02G088169 | 0.6 | ENCODE | 79.5 | +0.2 | 213 | 1.7 | ZBTB11 RBBP5 GABPA POLR2A HDAC2 PRDM10 ZFX ZBTB26 | THNSL2 FABP1 LOC101928347 |
| GH02G088125 | 1.3 | ENCODE dbSUPER | 33.8 | -41.3 | -41309 | 6.7 | FOXA2 ATF1 MLX ZFP64 ARID4B ZNF48 YY1 PAF1 ZNF202 SP5 | FABP1 THNSL2 KRCC1 GC02P088146 |
| GH02G088144 | 1 | ENCODE dbSUPER | 38.1 | -24.7 | -24694 | 3.0 | ELF3 ARID4B MAX RBBP5 THRB RAD21 RARA YY1 TEAD3 HOMEZ | THNSL2 FABP1 KRCC1 GC02P088146 |
| GH02G088212 | 1.2 | ENCODE dbSUPER | 23.5 | +42.4 | 42411 | 1.0 | ELF3 FOXA2 ARID4B RAD21 DNMT3B ZNF48 ZSCAN9 GATA4 ZNF143 CREM | THNSL2 RNY4P15 GC02M088230 PIR44570 |
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around THNSL2 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Location for THNSL2 Gene
- Chromosome:
- 2
- Start:
- 88,170,295 bp from pter
- End:
- 88,186,637 bp from pter
- Size:
- 16,343 bases
- Orientation:
- Plus strand
Genomic View for THNSL2 Gene
Genes around THNSL2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 2p11.2 by Ensembl
- 2p11.2 by Entrez Gene
- 2p11.2 by HGNC
THNSL2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for THNSL2 Gene
Proteins for THNSL2 Gene
-
Protein details for THNSL2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q86YJ6-THNS2_HUMAN
- Recommended name:
- Threonine synthase-like 2
- Protein Accession:
- Q86YJ6
- B3KTB1
- B5MDX8
- B7WPF8
- D9ZZB8
- Q6P2M7
- Q6PI27
- Q9NV54
Protein attributes for THNSL2 Gene
- Size:
- 484 amino acids
- Molecular mass:
- 54116 Da
- Cofactor:
- Name=pyridoxal 5-phosphate; Xref=ChEBI:CHEBI:597326;
- Quaternary structure:
- No Data Available
- SequenceCaution:
-
- Sequence=AAX88906.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=BAA91904.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};
Protein Expression for THNSL2 Gene
Selected DME Specific Peptides for THNSL2 Gene
- Q86YJ6:
-
- PRCCLAPASA
- AFSRFRHR
- TSGDTGS
Post-translational modifications for THNSL2 Gene
Other Protein References for THNSL2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for THNSL2
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-
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Protein Products
-
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- antibodies-online Proteins for THNSL2: See all 6
- Search antibodies-online for peptides
- Search GeneTex for Proteins for THNSL2
Domains & Families for THNSL2 Gene
Protein Domains for THNSL2 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for THNSL2 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q86YJ6- Family:
-
- Belongs to the threonine synthase family.
No data available for Gene Families for THNSL2 Gene
Function for THNSL2 Gene
Molecular function for THNSL2 Gene
- UniProtKB/Swiss-Prot Function:
- Isoform 1: Acts as a catabolic phospho-lyase on both gamma- and beta-phosphorylated substrates. Degrades O-phospho-threonine (PThr) to alpha-ketobutyrate, ammonia and phosphate (By similarity).
- UniProtKB/Swiss-Prot Function:
- Isoform SOFAT: Potent inducer of osteoblastic production of IL6. May act to exacerbate inflammation and/or bone turnover under inflammatory conditions.
Enzyme Numbers (IUBMB) for THNSL2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003674 | molecular_function | ND | -- |
| GO:0004795 | NOT threonine synthase activity | IBA | -- |
| GO:0005125 | cytokine activity | IEA | -- |
| GO:0016829 | lyase activity | IEA | -- |
| GO:0030170 | pyridoxal phosphate binding | ISS | 17034760 |
Phenotypes for THNSL2 Gene
- GenomeRNAi human phenotypes for THNSL2:
-
- Increased vaccinia virus (VACV) infection
- Dynamic nuclei (hole, folded or small irregular)
- Increased transferrin (TF) endocytosis
- Decreased HIV-LTR-beta-galactosidase protein expression
- Decreased viability of wild-type and TP53 knockout cells
- Decreased Tat-dependent HIV-LTR-beta-galactosidase protein expression
- Increased shRNA abundance with PLX4720
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
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-
-
ViGene Biosciences lentiviral particle packaged cDNA for THNSL2 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for THNSL2 gene
- Search ViGene Biosciences for THNSL2
CRISPR Products
-
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-
Santa Cruz Biotechnology (SCBT) CRISPR for THNSL2
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miRNA Products
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-
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-
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- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for THNSL2
-
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-
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-
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No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for THNSL2 Gene
Localization for THNSL2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for THNSL2 Gene
- Isoform SOFAT: Secreted. Note=Secreted by activated T-cells via a calcineurin-independent pathway.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| mitochondrion | 2 |
| cytosol | 2 |
| peroxisome | 1 |
| nucleus | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005575 | cellular_component | ND | -- |
| GO:0005576 | extracellular region | IEA | -- |
| GO:0005615 | extracellular space | IEA | -- |
Pathways & Interactions for THNSL2 Gene
No Data Available
Interacting Proteins for THNSL2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0008150 | biological_process | ND | -- |
| GO:0009071 | serine family amino acid catabolic process | ISS | 17034760 |
| GO:0009088 | NOT threonine biosynthetic process | IBA | -- |
| GO:0016311 | dephosphorylation | ISS | 17034760 |
| GO:0046360 | 2-oxobutyrate biosynthetic process | ISS | 17034760 |
No data available for Pathways by source and SIGNOR curated interactions for THNSL2 Gene
Drugs & Compounds for THNSL2 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Pyridoxal Phosphate | Nutra | 15 |
Transcripts for THNSL2 Gene
mRNA/cDNA for THNSL2 Gene
- (15) REFSEQ mRNAs :
- (10) Additional mRNA sequences :
- (140) Selected AceView cDNA sequences:
- (10) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for THNSL2 Gene
CRISPR Products
-
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-
Santa Cruz Biotechnology (SCBT) CRISPR for THNSL2
- GenScript: Design CRISPR guide RNA sequences for THNSL2
miRNA Products
- Search ViGene Biosciences for THNSL2
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for THNSL2
- Browse OriGene Inhibitory RNA Products For THNSL2
-
ViGene Biosciences ready-to-package AAV shRNAs for THNSL2 gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for THNSL2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for THNSL2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3a | · | 3b | ^ | 4a | · | 4b | · | 4c | · | 4d | ^ | 5a | · | 5b | ^ | 6a | · | 6b | · | 6c | ^ | 7 | ^ | 8a | · | 8b | ^ | 9a | · | 9b | ^ | 10a | · | 10b | ^ | 11 | ^ | 12 | ^ | 13a | · |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP9: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP10: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP11: |
| ExUns: | 13b | · | 13c | · | 13d |
|---|---|---|---|---|---|
| SP1: | |||||
| SP2: | |||||
| SP3: | |||||
| SP4: | |||||
| SP5: | |||||
| SP6: | |||||
| SP7: | |||||
| SP8: | |||||
| SP9: | |||||
| SP10: | |||||
| SP11: |
Expression for THNSL2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Lateral Plate Mesoderm (Gastrulation Derivatives)
- Paraxial Mesoderm (Gastrulation Derivatives)
This gene is overexpressed in Retina (28.0), Platelet (19.3), Testis (7.4), and Prostate (6.1).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for THNSL2 Gene
NURSA nuclear receptor signaling pathways regulating expression of THNSL2 Gene:
THNSL2SOURCE GeneReport for Unigene cluster for THNSL2 Gene:
Hs.740434Evidence on tissue expression from TISSUES for THNSL2 Gene
- Nervous system(4.3)
- Blood(4.2)
- Intestine(4.2)
- Skin(4.2)
Primer Products
-
OriGene qPCR primer pairs for THNSL2
No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for THNSL2 Gene
Orthologs for THNSL2 Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | THNSL2 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | THNSL2 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | THNSL2 34 35 |
|
||
| mouse (Mus musculus) |
Mammalia | Thnsl2 34 16 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Thnsl2 34 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | THNSL2 35 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | THNSL2 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | THNSL2 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | THNSL2 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | thnsl2 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | thnsl2 34 35 |
|
||
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | THR4 34 35 37 |
|
||
| K. lactis yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0C09020g 34 |
|
||
| bread mold (Neurospora crassa) |
Ascomycetes | NCU03425 34 |
|
||
| fission yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | SPAC9E9.06c 34 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 35 |
|
OneToOne |
- Species where no ortholog for THNSL2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for THNSL2 Gene
Variants for THNSL2 Gene
| SNP ID | Clin | Chr 02 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000041503 | -- | 88,179,591(+) | GCCTC(A/G)ATGAG | intron-variant | |
| rs1000062188 | -- | 88,173,512(+) | GACTC(C/T)AGAAT | intron-variant | |
| rs1000075820 | -- | 88,179,815(+) | AAAGG(A/G)GTCAT | intron-variant | |
| rs1000502816 | -- | 88,173,712(+) | CCTTC(A/G)CATAA | intron-variant | |
| rs1000732315 | -- | 88,182,122(+) | GGTAC(A/C)TAACT | intron-variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv61n16 | CNV | deletion | 17901297 |
| dgv6947n54 | CNV | gain | 21841781 |
| esv1550357 | CNV | insertion | 17803354 |
| esv1593020 | CNV | insertion | 17803354 |
| esv2518093 | CNV | insertion | 19546169 |
| nsv1072005 | CNV | deletion | 25765185 |
| nsv1130752 | CNV | deletion | 24896259 |
| nsv1148611 | CNV | deletion | 26484159 |
| nsv507021 | OTHER | sequence alteration | 20534489 |
| nsv582383 | CNV | gain | 21841781 |
| nsv582384 | CNV | loss | 21841781 |
| nsv582386 | CNV | loss | 21841781 |
| nsv834289 | CNV | gain | 17160897 |
Residual Variation Intolerance Score:
90.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
4.63;
65.58% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for THNSL2 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- THNSL2
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for THNSL2 Gene
Disorders for THNSL2 Gene
Relevant External Links for THNSL2
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- THNSL2
No disorders were found for THNSL2 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for THNSL2 Gene
Publications for THNSL2 Gene
- A novel T cell cytokine, secreted osteoclastogenic factor of activated T cells, induces osteoclast formation in a RANKL-independent manner. (PMID: 19877052) Rifas L. … Weitzmann M.N. (Arthritis Rheum. 2009) 2 3 4 64
- A threonine synthase homolog from a mammalian genome. (PMID: 17034760) Donini S. … Peracchi A. (Biochem. Biophys. Res. Commun. 2006) 2 3 64
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
- Expression of SOFAT by T-A and B-lineage cells may contribute to bone loss. (PMID: 27035849) Jarry C.R. … Napimoga M.H. (Mol Med Rep 2016) 3 64
- In vitro evaluation of the biological effect of SOFAT on osteoblasts. (PMID: 25916677) Napimoga M.H. … Martinez E.F. (Int. Immunopharmacol. 2015) 3 64
Products for THNSL2 Gene
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- VectorBuilder custom plasmid, inducible vectors for THNSL2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for THNSL2
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for THNSL2 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
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