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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

THNSL2 Gene

protein-coding   GIFtS: 50
GCID: GC02P088469

threonine synthase-like 2 (S. cerevisiae)
  Search for THNSL2
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 Human Malady Compendium 
Biological research products
for THNSL2    

Aliases
for THNSL2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Threonine Synthase-Like 2 (S. Cerevisiae)1 2     Secreted Osteoclastogenic Factor Of Activated T Cells2
Secreted Osteoclastogenic Factor Of Activated T-Cells2 3     Threonine Synthase-Like 22
SOFAT2 3     EC 4.2.3.-3
TSH22 3     EC 4.2.38
FLJ109161     EC 4.2.3.18
THS22     

External Ids:    HGNC: 256021   Entrez Gene: 552582   Ensembl: ENSG000001441157   OMIM: 6112615   UniProtKB: Q86YJ63   

Export aliases for THNSL2 gene to outside databases

Previous GC identifers: GC02P088251 GC02P087392


Summaries
for THNSL2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for THNSL2:
This gene encodes a threonine synthase-like protein. A similar enzyme in mouse can catalyze the degradation of
O-phospho-homoserine to a-ketobutyrate, phosphate, and ammonia. This protein also has phospho-lyase activity on both
gamma and beta phosphorylated substrates. In mouse an alternatively spliced form of this protein has been shown to act
as a cytokine and can induce the production of the inflammatory cytokine IL6 in osteoblasts. Alternate splicing
results in multiple transcript variants. (provided by RefSeq, Sep 2011)

UniProtKB/Swiss-Prot: THNS2_HUMAN, Q86YJ6
Function: Isoform 1: Acts as a catabolic phospho-lyase on both gamma- and beta-phosphorylated substrates. Degrades
O-phospho-threonine (PThr) to alpha-ketobutyrate, ammonia and phosphate (By similarity)
Function: Isoform SOLAT: Potent inducer of osteoblastic production of IL6. May act to exacerbate inflammation and/or
bone turnover under inflammatory conditions




Genomic Views
for THNSL2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NC_018913.1  NT_022184.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the THNSL2 gene promoter:
         Nkx3-1   AhR   Nkx3-1 v4   AML1a   Nkx3-1 v1   Arnt   Nkx3-1 v2   COMP1   Nkx3-1 v3   c-Myb   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: THNSL2 promoter sequence
   Search SABiosciences Chromatin IP Primers for THNSL2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat THNSL2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p11.2   Ensembl cytogenetic band:  2p11.2   HGNC cytogenetic band: 2p11.2

THNSL2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
THNSL2 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P088469:  view genomic region     (about GC identifiers)

Start:
 88,469,835 bp from pter      End:
 88,486,146 bp from pter
Size:
 16,312 bases      Orientation:
 plus strand

Proteins
for THNSL2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: THNS2_HUMAN, Q86YJ6 (See protein sequence)
Recommended Name: Threonine synthase-like 2  
Size: 484 amino acids; 54116 Da
Cofactor: Pyridoxal phosphate (By similarity)
Subcellular location: Isoform SOLAT: Secreted. Note=Secreted by activated T-cells via a calcineurin-independent pathway
Sequence caution: Sequence=AAX88906.1; Type=Erroneous gene model prediction; Sequence=BAA91904.1; Type=Erroneous
initiation; Note=Translation N-terminally extended;
Secondary accessions: B3KTB1 B5MDX8 B7WPF8 D9ZZB8 Q6P2M7 Q6PI27 Q9NV54
Alternative splicing: 5 isoforms:  Q86YJ6-1   Q86YJ6-2   Q86YJ6-3   Q86YJ6-4   Q86YJ6-5   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for THNSL2: NX_Q86YJ6

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q86YJ6

    • 3 DME Specific Peptides for THNSL2 (Q86YJ6)
     TSGDTGS  AFSRFRHR  PRCCLAPASA 

    THNSL2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (3 alternative transcripts): 
    NP_001231605.1  NP_001231607.1  NP_060741.3  

    ENSEMBL proteins: 
     ENSP00000391300   ENSP00000407553   ENSP00000339563   ENSP00000327323   ENSP00000351402  
     ENSP00000366464   ENSP00000384475  

    Human Recombinant Protein Products: 
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    OriGene Purified Protein: THNSL2
    OriGene Protein Over-expression Lysate: THNSL2
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    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for THNSL2

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--
    GO:0005615extracellular space IEA--


    THNSL2 for ontologies           About GeneDecksing



    THNSL2 Antibody Products: 
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    Uscn Antibodies for THNSL2
    ThermoFisher Antibodies for THNSL2

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    Uscn ELISAs and CLIAs for THNSL2

    Protein Domains /
    Families
    for THNSL2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    THNSL2 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR004450 Thr_synthase_like
     IPR001926 Trp_syn_b_sub_like_PLP_eny_SF

    Graphical View of Domain Structure for InterPro Entry Q86YJ6

    ProtoNet protein and cluster: Q86YJ6

    1 Blocks protein family: IPB001926 Pyridoxal-5'-phosphate-dependent enzyme

    UniProtKB/Swiss-Prot: THNS2_HUMAN, Q86YJ6
    Similarity: Belongs to the threonine synthase family


    Function
    for THNSL2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: THNS2_HUMAN, Q86YJ6
    Function: Isoform 1: Acts as a catabolic phospho-lyase on both gamma- and beta-phosphorylated substrates. Degrades
    O-phospho-threonine (PThr) to alpha-ketobutyrate, ammonia and phosphate (By similarity)
    Function: Isoform SOLAT: Potent inducer of osteoblastic production of IL6. May act to exacerbate inflammation and/or
    bone turnover under inflammatory conditions

    Enzyme Numbers (IUBMB): EC 4.2.3.12 EC 4.2.32 EC 4.2.3.-1

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat THNSL2
    1 QIAGEN miScript miRNA Assays for microRNA that regulate THNSL2:
    hsa-miR-1911*
    SwitchGear 3'UTR luciferase reporter plasmid: THNSL2 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for THNSL2 (see all 7)
    OriGene shRNA RFP: THNSL2
    OriGene siRNA: THNSL2
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    Gene Editing
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    Clone
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    Cell Line
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    Search LifeMap BioReagents cell lines for THNSL2

    In Situ Assay
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    Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0003824catalytic activity ----
    GO:0004795threonine synthase activity IEA--
    GO:0005125cytokine activity IEA--
    GO:0030170pyridoxal phosphate binding ISS17034760


    THNSL2 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for THNSL2:
     Decreased TP53 protein express 


    Pathways & Interactions
    for THNSL2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for THNSL2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 17)

    5/174 Interacting proteins for THNSL2 (Q86YJ62, 3 ENSP000003273234) via UniProtKB, MINT, STRING, and/or I2D (see all 174)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ZBTB16Q055162, 3MINT-65640 I2D: score=5 
    ARPC3O151452, 3MINT-63094 I2D: score=4 
    EIF2S1P051983, ENSP000002563834I2D: score=3 STRING: ENSP00000256383
    HMGCS1Q015813, ENSP000003227064I2D: score=3 STRING: ENSP00000322706
    OSGEPQ9NPF43, ENSP000002065424I2D: score=1 STRING: ENSP00000206542
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008150biological_process ND--
    GO:0009071serine family amino acid catabolic process ISS17034760
    GO:0009088threonine biosynthetic process IEA--
    GO:0016311dephosphorylation ISS17034760
    GO:00463602-oxobutyrate biosynthetic process ISS17034760


    THNSL2 for ontologies           About GeneDecksing



    Drugs & Compounds
    for THNSL2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for THNSL2

    1 HMDB Compound for THNSL2    About this table
    CompoundSynonyms CAS #PubMed Ids
    Pyridoxal 5'-phosphateApolon B6 (see all 27)54-47-7--
    Search CenterWatch for drugs/clinical trials and news about THNSL2 / THNS2 

    Transcripts
    for THNSL2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for THNSL2 gene (3 alternative transcripts): 
    NM_001244676.1  NM_001244678.1  NM_018271.4  

    Unigene Cluster for THNSL2:

    Threonine synthase-like 2 (S. cerevisiae)
    Hs.740434  [show with all ESTs]
    Unigene Representative Sequence: AK095303
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000419759 ENST00000449349 ENST00000343544(uc002ssw.4) ENST00000324166(uc002ssy.4)
    ENST00000475910(uc021vkq.1) ENST00000496844 ENST00000476349 ENST00000464022
    ENST00000496165 ENST00000358591(uc021vkr.1) ENST00000377254(uc002sta.4 uc010fhe.3)
    ENST00000402102

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat THNSL2
    1 QIAGEN miScript miRNA Assays for microRNA that regulate THNSL2:
    hsa-miR-1911*
    SwitchGear 3'UTR luciferase reporter plasmid: THNSL2 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for THNSL2 (see all 7)
    OriGene shRNA RFP: THNSL2
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    Clone
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    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: THNSL2 (NM_018271)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat THNSL2 
    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat THNSL2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat THNSL2

    Additional cDNA sequence: 

    AK001778.1 AK095303.1 AK289486.1 AK315831.1 AL832746.1 BC035315.1 BC047758.2 BC050699.2 
    BC064423.1 HM185274.1 

    12 DOTS entries:

    DT.97845078  DT.453751  DT.101984374  DT.97803858  DT.92423625  DT.75146175  DT.120958714  DT.70105426 
    DT.101956831  DT.120958704  DT.100832291  DT.120958703 

    24/140 AceView cDNA sequences (see all 140):

    BG481438 AI424348 CR620866 CB152560 CN483939 BU608749 AA425496 CB157574 
    BM714547 CR613903 BU752297 AI972817 BM450014 BU787850 BC035315 BE744167 
    BM924722 CD671198 BM920973 AU133626 BM762998 BX348409 AI968753 AK001778 

    GeneLoc Exon Structure

    5/11 Alternative Splicing Database (ASD) splice patterns (SP) for THNSL2 (see all 11)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c · 4d ^ 5a · 5b ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12 ^ 13a ·
    SP1:                          -     -     -                                                     -                                         -     -               
    SP2:                                                                                            -                                         -           -         
    SP3:                                                                                            -                 -     -                 -           -         
    SP4:                                -     -     -                                               -                                                               
    SP5:                                                                                            -                                         -     -     -         

    ExUns: 13b · 13c · 13d
    SP1:                  
    SP2:                  
    SP3:                  
    SP4:                  
    SP5:                  


    ECgene alternative splicing isoforms for THNSL2

    Expression
    for THNSL2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    THNSL2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    THNSL2 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 6 LifeMap Cells 
    NameCategory
    PureStem™ progenitor E68 (Embryonic Progenitor Cell)
    PureStem™ epithelial progenitor E164 (Embryonic Progenitor Cell)Intermediate Mesoderm, Kidney
    PureStem™ mesenchymal progenitor E15 (Embryonic Progenitor Cell)Adipose, Bone, Cartilage
    PureStem™ progenitor E44 (Embryonic Progenitor Cell)
    PureStem™ progenitor E69 (Embryonic Progenitor Cell)
    PureStem™ progenitor F15 (Embryonic Progenitor Cell)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See THNSL2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for THNSL2

    SOURCE GeneReport for Unigene cluster: Hs.740434
        SABiosciences Custom PCR Arrays for THNSL2
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    In Situ
    Assay Products:     
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    Orthologs
    for THNSL2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the last universal common ancestor (LUCA).

    Orthologs for THNSL2 gene from 5/23 species (see all 23)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves THNSL21 threonine synthase-like 2 (S. cerevisiae) 69.82(n)
    68.84(a)    		   422927  XM_420866.3  XP_420866.2 
    lizard
    (Anolis carolinensis)    		 Reptilia THNSL26
    THNSL16
    		 --
    		 66(a)
    17(a)
    		 1 ↔ 1
    possible ortholog
    		 6(59386528-59400123)
    6(15199139-15201346)
    zebrafish
    (Danio rerio)    		 Actinopterygii thnsl21 threonine synthase-like 2 (S. cerevisiae) 58.53(n)
    53.26(a)    		   641568  NM_001037566.1  NP_001032655.1 
    baker's yeast
    (Saccharomyces cerevisiae)    		 Saccharomycetes THR4(YCR053W)4
    THR41    		 Threonine synthase, conserved protein that catalyzes more4
    Thr4p1    		 48.31(n)1
    40.9(a)1    		   3(216697-218241)4
    8504201, 4  NP_009982.11, 4 
    E. coli
    (Escherichia coli)    		 Gamma proteobacteria thrC6
    		 threonine synthase
    		 31(a)
    		 1 → many
    		 Chromosome(3734-5020)


    ENSEMBL Gene Tree for THNSL2 (if available)
    TreeFam Gene Tree for THNSL2 (if available) 

    Paralogs
    for THNSL2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for THNSL2 gene
    THNSL12  

    THNSL2 for paralogs           About GeneDecksing



    Genomic Variants
    for THNSL2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/328 NCBI SNPs in THNSL2 are shown (see all 328)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 2 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1886126101,2
    		--88467827(+) TGCATA/GGACCC 2 -- us2k10--------
    rs1378905701,2
    		--88467860(+) CTGGAA/GGATCG 2 -- us2k10--------
    rs768303281,2
    		F,--88467865(+) AGATCG/ATTGGC 2 -- us2k11Minor allele frequency- A:0.02EA 120
    rs1416134771,2
    		--88467877(+) TCAACA/GTTATA 2 -- us2k10--------
    rs44901851,2
    		C,F,A,H,--88467934(+) CGGTTT/GCTAAT 2 -- us2k197Minor allele frequency- G:0.22NS EA PA EU CA WA NA CSA 5180
    rs1926145071,2
    		--88468008(+) CTTCGC/GGATTC 2 -- us2k10--------
    rs1832959421,2
    		--88468131(+) CTGAGA/CGTTTT 2 -- us2k10--------
    rs285149111,2
    		C,F,--88468153(+) TTCTGG/AGNNNN 2 -- us2k16Minor allele frequency- A:0.15WA NA CSA 246
    rs1868711391,2
    		--88468261(+) AGAGGA/TCCGTG 2 -- us2k10--------
    rs1176254921,2
    		--88468263(+) AGGTCC/TGTGGA 2 -- us2k11Minor allele frequency- T:0.01EA 120

    HapMap Linkage Disequilibrium report for THNSL2 (88469835 - 88486146 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for THNSL2
         1 Indel: 97910

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    Disorders / Diseases
    for THNSL2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    THNSL2 for disorders           About MalaCards

    THNSL2 for disorders           About GeneDecksing

    OMIM gene information: 611261    OMIM disorders: --


    Export disorders for THNSL2 gene to outside databases

    Publications
    for THNSL2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for THNSL2 gene, integrated from 9 sources (see all 11):
    (articles sorted by number of sources associating them with THNSL2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel T cell cytokine, secreted osteoclastogenic fa ctor of activated T cells, induces osteoclast formation in a RANKL-independent manner. (PubMed id 19877052)1, 2 Rifas L. and Weitzmann M.N. (2009)
    2. A threonine synthase homolog from a mammalian genome. (PubMed id 17034760)1, 3 Donini S....Peracchi A. (2006)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women. (PubMed id 22589738)1 Fox C.S....Borecki I.B. (2012)
    5. Bimodal distribution of RNA expression levels in huma n skeletal muscle tissue. (PubMed id 21299892)1 Mason C.C....Bogardus C. (2011)
    6. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
    7. Genome-wide prediction of mammalian enhancers based on analysis of transcription-factor binding affinity. (PubMed id 16413481)1 Hallikas O....Taipale J. (2006)
    8. A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070)1 Stelzl U.... Wanker E.E. (2005)
    9. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)2 Hillier L.W....Wilson R.K. (2005)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)

    External Searches for THNSL2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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    Genome Databases showing THNSL2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 55258 HGNC: 25602 AceView: FLJ10916 Ensembl:ENSG00000144115 euGenes: HUgn55258
    ECgene: THNSL2 H-InvDB: THNSL2

    Other Databases showing THNSL2 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing THNSL2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for THNSL2 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for THNSL2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for THNSL2 gene:
    Search GeneIP for patents involving THNSL2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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