THNSL1 Gene
protein-coding GIFtS: 47
GCID: GC10P025345
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threonine synthase-like 1 (S. cerevisiae)(Previous name: threonine synthase-like 1 (bacterial) )
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Aliases
for THNSL1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Threonine Synthase-Like 1 (S. Cerevisiae)1 2 | | TSH12 3 | | FLJ220021 | | Threonine Synthase-Like 1 (Bacterial)1 | | Threonine Synthase-Like 12 |
Export aliases for THNSL1 gene to outside databasesPrevious GC identifers: GC10P025310 GC10P024966 |
Summaries
for THNSL1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for THNSL1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000010.10 NC_018921.1 NT_008705.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the THNSL1 gene promoter:
Pbx1a GATA-3 CUTL1 C/EBPalpha GATA-1 GATA-2 POU2F1 POU2F1a En-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for THNSL1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat THNSL1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 10p12.1 Ensembl cytogenetic band: 10p12.1 HGNC cytogenetic band: 10p12.31THNSL1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 10 GeneLoc Exon Structure GeneLoc location for GC10P025345: view genomic region
(about GC identifiers)
Start:
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25,305,508 bp from pter |
End:
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25,315,593 bp from pter |
Size:
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10,086 bases |
Orientation:
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plus strand |
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Proteins
for THNSL1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: THNS1_HUMAN, Q8IYQ7 (See
protein sequence)Recommended Name: Threonine synthase-like 1 Size: 743 amino acids; 83070 Da
Cofactor: Pyridoxal phosphate (By similarity)
Secondary accessions: B3KWL1 D3DRV3 Q5VV21Explore the universe of human proteins at neXtProt for THNSL1: NX_Q8IYQ7
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8IYQ7
THNSL1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_079114.3
ENSEMBL proteins: ENSP00000434887 ENSP00000365534
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005575 | cellular_component |
ND | -- |
THNSL1 for ontologies About GeneDecksing
THNSL1 Antibody Products:
Assay Products for THNSL1: |
Protein
Domains /
Families
for THNSL1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
THNSL1 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q8IYQ7ProtoNet protein and cluster: Q8IYQ7 2 Blocks protein families: IPB000623 Shikimate kinase family signature IPB001926 Pyridoxal-5'-phosphate-dependent enzyme
UniProtKB/Swiss-Prot: THNS1_HUMAN, Q8IYQ7Similarity: Belongs to the threonine synthase family |
Function
for THNSL1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for THNSL1 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for THNSL1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: THNSL1 (NM_024838) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for THNSL1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat THNSL1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for THNSL1 |
Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table
THNSL1 for ontologies About GeneDecksing
|
Pathways & Interactions
for THNSL1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for THNSL1
STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)
2 Interacting proteins for THNSL1 (Q8IYQ73 ENSP000003655344) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008150 | biological_process |
ND | -- | | GO:0009088 | threonine biosynthetic process |
IEA | -- |
THNSL1 for ontologies About GeneDecksing
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Drugs & Compounds
for THNSL1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for THNSL1
2 HMDB Compounds for THNSL1 About this table
2 DrugBank Compounds for THNSL1 About this table
Search CenterWatch for drugs/clinical trials and news about THNSL1 / THNS1
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Transcripts
for THNSL1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for THNSL1 gene: NM_024838.4 Unigene Cluster for THNSL1: Threonine synthase-like 1 (S. cerevisiae) Hs.645274 [show with all ESTs]Unigene Representative Sequence: NM_0248382 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000524413 ENST00000376356(uc001isi.4)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for THNSL1 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for THNSL1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: THNSL1 (NM_024838) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for THNSL1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat THNSL1 |
Additional cDNA sequence: AK025655.1 AK094362.1 AK125249.1 BC016697.1 BC035132.2 BX647989.1 CR457346.1 4 DOTS entries: DT.453223 DT.121272257 DT.91941747 DT.97786822 24/56 AceView cDNA sequences (see all 56): CR615274 BC016697 AK125249 BC035132 AK025655 AA622484 AA599699 BM782407 AA868786 BM675000 BX116415 F11442 BX394200 AI613315 BX375707 F09105 BX642373 BU785162 BU784905 NM_024838 BI549966 BU740152 BU740181 BX647989
GeneLoc Exon Structure
2 Alternative Splicing Database (ASD) splice patterns (SP) for THNSL1 About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3a | · | 3b |
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| SP1: | | | | | - | | | | | | | | |
| SP2: | | | | | | | | | | | | |
ECgene alternative splicing isoforms for THNSL1
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Expression
for THNSL1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| THNSL1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CAATAATAAA
About this image
See THNSL1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for THNSL1
SOURCE GeneReport for Unigene cluster: Hs.645274
SABiosciences Custom PCR Arrays for THNSL1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for THNSL1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat THNSL1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat THNSL1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat THNSL1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for THNSL1 |
Orthologs
for THNSL1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the last universal common ancestor (LUCA).
Orthologs for THNSL1 gene from 6/20 species (see all 20) About this table
ENSEMBL Gene Tree for THNSL1 (if available)
TreeFam Gene Tree for THNSL1 (if available) |
Paralogs
for THNSL1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for THNSL1 gene
- THNSL22
THNSL1 for paralogs About GeneDecksing
|
Genomic Variants
for THNSL1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 10 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for THNSL1 (25305508 - 25315593 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for THNSL1: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing THNSL1 |
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Disorders
/ Diseases
for THNSL1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
THNSL1 for disorders About GeneDecksing
OMIM gene information: 611260
OMIM disorders: --
2  diseases for THNSL1: About MalaCardsalzheimer's disease pneumonia
Human Genome Epidemiology (HuGE) Navigator: THNSL1 (1 document)
Export disorders for THNSL1 gene to outside databases
|
Publications
for THNSL1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for THNSL1 gene, integrated from 9 sources (see all 12):
(articles sorted by number of sources associating them with THNSL1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- A functional peptidyl-tRNA hydrolase, ICT1, has been recruited into the human mitochondrial ribosome. (PubMed id 20186120)1 Richter R....Chrzanowska-Lightowlers Z.M. (2010)
- Lysine acetylation targets protein complexes and co-regulates major cellular functions. (PubMed id 19608861)2 Choudhary C.... Mann M. (2009)
- Defining the human deubiquitinating enzyme interactio n landscape. (PubMed id 19615732)1 Sowa M.E....Harper J.W. (2009)
- Drugs, their targets and the nature and number of dru g targets. (PubMed id 17016423)7 Imming P....Meyer A. (2006)
- A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451)1 Grupe A....Goate A. (2006)
- How many drug targets are there? (PubMed id 17139284)7 Overington J.P....Hopkins A.L. (2006)
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External Searches for THNSL1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing THNSL1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing THNSL1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing THNSL1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for THNSL1 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for THNSL1 gene:
Search GeneIP for patents involving THNSL1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for THNSL1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for THNSL1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for THNSL1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for THNSL1 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for THNSL1 | | OriGene 3'-UTR Clone for THNSL1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for THNSL1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for THNSL1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for THNSL1 | | OriGene Custom Protein Services for THNSL1 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat THNSL1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing THNSL1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat THNSL1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat THNSL1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat THNSL1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat THNSL1 |
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| | | | Search Tocris compounds for THNSL1 |
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 | | | THNSL1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for THNSL1 |
|  |  |  | | | | Search ThermoFisher Antibodies for THNSL1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat THNSL1 |
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