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Aliases for THNSL1 Gene

Aliases for THNSL1 Gene

  • Threonine Synthase-Like 1 2 3
  • TSH1 3 4
  • Threonine Synthase-Like 1 (S. Cerevisiae) 2
  • Threonine Synthase-Like 1 (Bacterial) 2

External Ids for THNSL1 Gene

Previous GeneCards Identifiers for THNSL1 Gene

  • GC10P025310
  • GC10P025345

Summaries for THNSL1 Gene

GeneCards Summary for THNSL1 Gene

THNSL1 (Threonine Synthase-Like 1) is a Protein Coding gene. Diseases associated with THNSL1 include aural atresia, congenital. GO annotations related to this gene include pyridoxal phosphate binding and threonine synthase activity. An important paralog of this gene is THNSL2.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for THNSL1 Gene

Genomics for THNSL1 Gene

Regulatory Elements for THNSL1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for THNSL1 Gene

Chromosome:
10
Start:
25,016,579 bp from pter
End:
25,026,664 bp from pter
Size:
10,086 bases
Orientation:
Plus strand

Genomic View for THNSL1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for THNSL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for THNSL1 Gene

Proteins for THNSL1 Gene

  • Protein details for THNSL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IYQ7-THNS1_HUMAN
    Recommended name:
    Threonine synthase-like 1
    Protein Accession:
    Q8IYQ7
    Secondary Accessions:
    • B3KWL1
    • D3DRV3
    • Q5VV21

    Protein attributes for THNSL1 Gene

    Size:
    743 amino acids
    Molecular mass:
    83070 Da
    Cofactor:
    Name=pyridoxal 5-phosphate; Xref=ChEBI:CHEBI:597326;
    Quaternary structure:
    No Data Available

neXtProt entry for THNSL1 Gene

Proteomics data for THNSL1 Gene at MOPED

Post-translational modifications for THNSL1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for THNSL1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for THNSL1 Gene

Domains & Families for THNSL1 Gene

Suggested Antigen Peptide Sequences for THNSL1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8IYQ7

UniProtKB/Swiss-Prot:

THNS1_HUMAN :
  • Belongs to the threonine synthase family.
Family:
  • Belongs to the threonine synthase family.
genes like me logo Genes that share domains with THNSL1: view

No data available for Gene Families for THNSL1 Gene

Function for THNSL1 Gene

Gene Ontology (GO) - Molecular Function for THNSL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0004795 threonine synthase activity IBA --
GO:0030170 pyridoxal phosphate binding IBA --
genes like me logo Genes that share ontologies with THNSL1: view
genes like me logo Genes that share phenotypes with THNSL1: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for THNSL1

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for THNSL1 Gene

Localization for THNSL1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for THNSL1 Gene COMPARTMENTS Subcellular localization image for THNSL1 gene
Compartment Confidence
mitochondrion 4
nucleus 4
cytosol 2

Gene Ontology (GO) - Cellular Components for THNSL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
GO:0005739 mitochondrion IDA --
genes like me logo Genes that share ontologies with THNSL1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for THNSL1 Gene

Pathways & Interactions for THNSL1 Gene

SuperPathways for THNSL1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for THNSL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
GO:0009088 threonine biosynthetic process IBA --
genes like me logo Genes that share ontologies with THNSL1: view

No data available for Pathways by source and SIGNOR curated interactions for THNSL1 Gene

Drugs & Compounds for THNSL1 Gene

(2) Drugs for THNSL1 Gene - From: HMDB and DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
L-Threonine Approved Nutra Target 0
Pyridoxal Phosphate Nutra Target, cofactor 14
genes like me logo Genes that share compounds with THNSL1: view

Transcripts for THNSL1 Gene

mRNA/cDNA for THNSL1 Gene

Unigene Clusters for THNSL1 Gene

Threonine synthase-like 1 (S. cerevisiae):
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for THNSL1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for THNSL1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b
SP1: -
SP2:

Relevant External Links for THNSL1 Gene

GeneLoc Exon Structure for
THNSL1
ECgene alternative splicing isoforms for
THNSL1

Expression for THNSL1 Gene

mRNA expression in normal human tissues for THNSL1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for THNSL1 Gene

This gene is overexpressed in Lymph node (7.3) and Liver (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for THNSL1 Gene



SOURCE GeneReport for Unigene cluster for THNSL1 Gene Hs.645274

genes like me logo Genes that share expression patterns with THNSL1: view

Protein tissue co-expression partners for THNSL1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for THNSL1 Gene

Orthologs for THNSL1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for THNSL1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia THNSL1 35
  • 90.4 (n)
  • 90.85 (a)
THNSL1 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia THNSL1 35
  • 91.7 (n)
  • 91.25 (a)
THNSL1 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Thnsl1 35
  • 84.39 (n)
  • 82.64 (a)
Thnsl1 16
Thnsl1 36
  • 82 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia THNSL1 35
  • 99.37 (n)
  • 99.6 (a)
THNSL1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Thnsl1 35
  • 82.93 (n)
  • 81.94 (a)
oppossum
(Monodelphis domestica)
Mammalia THNSL1 36
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia THNSL1 36
  • 77 (a)
OneToOne
chicken
(Gallus gallus)
Aves THNSL1 35
  • 73.1 (n)
  • 69.63 (a)
THNSL1 36
  • 69 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia THNSL1 36
  • 64 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.13522 35
thnsl1 35
  • 69.62 (n)
  • 66.81 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC101883988 35
  • 60.38 (n)
  • 58.12 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes THR4 36
  • 32 (a)
OneToMany
Species with no ortholog for THNSL1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for THNSL1 Gene

ENSEMBL:
Gene Tree for THNSL1 (if available)
TreeFam:
Gene Tree for THNSL1 (if available)

Paralogs for THNSL1 Gene

Paralogs for THNSL1 Gene

(1) SIMAP similar genes for THNSL1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with THNSL1: view

Variants for THNSL1 Gene

Sequence variations from dbSNP and Humsavar for THNSL1 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
VAR_052545 -
VAR_052546 -
VAR_058869 -
VAR_061893 -

Variation tolerance for THNSL1 Gene

Residual Variation Intolerance Score: 58.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.06; 75.22% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for THNSL1 Gene

HapMap Linkage Disequilibrium report
THNSL1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for THNSL1 Gene

Disorders for THNSL1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for THNSL1 Gene - From: OMIM

Disorder Aliases PubMed IDs
aural atresia, congenital
  • aural atresia, congenital, with hyposmia
- elite association

Relevant External Links for THNSL1

Genetic Association Database (GAD)
THNSL1
Human Genome Epidemiology (HuGE) Navigator
THNSL1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
THNSL1
genes like me logo Genes that share disorders with THNSL1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for THNSL1 Gene

Publications for THNSL1 Gene

  1. A threonine synthase homolog from a mammalian genome. (PMID: 17034760) Donini S. … Peracchi A. (Biochem. Biophys. Res. Commun. 2006) 2 67
  2. How many drug targets are there? (PMID: 17139284) Overington J.P. … Hopkins A.L. (Nat Rev Drug Discov 2006) 25 26
  3. Drugs, their targets and the nature and number of drug targets. (PMID: 17016423) Imming P. … Meyer A. (Nat Rev Drug Discov 2006) 25 26
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  5. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y. … Zou H. (J. Proteomics 2014) 67

Products for THNSL1 Gene

Sources for THNSL1 Gene

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