THG1L Gene
protein-coding GIFtS: 49
GCID: GC05P157159
|
|
tRNA-histidine guanylyltransferase 1-like (S. cerevisiae)
| |
Aliases
for THG1L gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| TRNA-Histidine Guanylyltransferase 1-Like (S. Cerevisiae)1 2 | | Induced By High Glucose-12 | | ICF451 2 3 | | Probable TRNA(His) Guanylyltransferase2 | | Interphase Cytoplasmic Foci Protein 452 3 | | EC 2.7.7.793 | | FLJ116011 | | TRNA-Histidine Guanylyltransferase3 | | FLJ205461 | | EC 2.7.78 | | IHG-12 | | EC 2.7.7.68 |
Export aliases for THG1L gene to outside databasesPrevious GC identifers: GC05P157090 GC05P152246 |
Summaries
for THG1L gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: THG1_HUMAN, Q9NWX6Function: Adds a GMP to the 5'-end of tRNA(His) after transcription and RNase P cleavage. This step is essential forproper recognition of the tRNA and for the fidelity of protein synthesis
Gene Wiki entry for THG1L
|
Genomic Views
for THG1L gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000005.9 NC_018916.1 NT_023133.13
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the THG1L gene promoter:
TBP p53 Arnt RORalpha2 CREB PPAR-gamma1 deltaCREB PPAR-gamma2 TGIF RSRFC4
Other transcription factors
Search SABiosciences Chromatin IP Primers for THG1L
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat THG1L |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 5q33.3 Ensembl cytogenetic band: 5q33.3 HGNC cytogenetic band: 5q33.3THG1L Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 5 GeneLoc Exon Structure GeneLoc location for GC05P157159: view genomic region
(about GC identifiers)
Start:
|
157,158,205 bp from pter |
End:
|
157,168,456 bp from pter |
Size:
|
10,252 bases |
Orientation:
|
plus strand |
|
Proteins
for THG1L gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: THG1_HUMAN, Q9NWX6 (See
protein sequence)Recommended Name: Probable tRNA(His) guanylyltransferase Size: 298 amino acids; 34831 Da
Cofactor: Binds 2 magnesium ions per subunit
Subunit: Homotetramer
Subcellular location: Cytoplasm. Note=Found near the nuclear membrane
Sequence caution: Sequence=AAH01523.2; Type=Erroneous initiation; Note=Translation N-terminally extended;Sequence=AAH01852.2; Type=Erroneous initiation; Note=Translation N-terminally extended;
4 PDB 3D structures from  and Proteopedia  for THG1L:3OTB (3D)
3OTC (3D)
3OTD (3D)
3OTE (3D)
Secondary accessions: D3DQJ5 Q53G12 Q7L5R3 Q9H0S2Explore the universe of human proteins at neXtProt for THG1L: NX_Q9NWX6
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9NWX6
4/5 DME Specific Peptides for THG1L (Q9NWX6) (see all 5)
THG1L Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_060342.2
ENSEMBL proteins: ENSP00000231198 ENSP00000428387 ENSP00000431090
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
THG1L for ontologies About GeneDecksing
THG1L Antibody Products:
Assay Products for THG1L: |
Protein
Domains /
Families
for THG1L gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
THG1L for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9NWX6ProtoNet protein and cluster: Q9NWX6 UniProtKB/Swiss-Prot: THG1_HUMAN, Q9NWX6Similarity: Belongs to the tRNA(His) guanylyltransferase family |
Function
for THG1L gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: THG1_HUMAN, Q9NWX6Function: Adds a GMP to the 5'-end of tRNA(His) after transcription and RNase P cleavage. This step is essential forproper recognition of the tRNA and for the fidelity of protein synthesisCatalytic activity: p-tRNA(His) + ATP + GTP = pppG-P-tRNA(His) + AMP + diphosphateEnzyme Numbers (IUBMB): EC 2.7.7.62 EC 2.7.72 EC 2.7.7.791
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for THG1L (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for THG1L (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: THG1L (NM_017872) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for THG1L | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat THG1L |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for THG1L |
Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6): About this table
THG1L for ontologies About GeneDecksing
|
Pathways & Interactions
for THG1L gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for THG1L
STRING Interaction
Network Preview (showing 5 interactants - click image to see 9)
5/43 Interacting proteins for THG1L (Q9NWX62, 3 ENSP000002311984) via UniProtKB, MINT, STRING, and/or I2D (see all 43)About this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table
THG1L for ontologies About GeneDecksing
|
Drugs & Compounds
for THG1L gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for THG1L
Search CenterWatch for drugs/clinical trials and news about THG1L / THG1
|
Transcripts
for THG1L gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for THG1L gene: NM_017872.3 Unigene Cluster for THG1L: TRNA-histidine guanylyltransferase 1-like (S. cerevisiae) Hs.353090 [show with all ESTs]Unigene Representative Sequence: AK2231193 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000231198(uc003lxd.3 uc011ddu.2) ENST00000521655 ENST00000523575
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for THG1L (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for THG1L (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: THG1L (NM_017872) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for THG1L | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat THG1L |
Additional cDNA sequence: AF086486.1 AF110136.1 AK000553.1 AK023355.1 AK223119.1 AK304590.1 AL136669.1 AY463216.1 BC001523.2 BC001852.2 BC023521.2 CR533503.1 7 DOTS entries: DT.452261 DT.100042208 DT.97844022 DT.95300405 DT.97844023 DT.87046144 DT.120862122 24/115 AceView cDNA sequences (see all 115): N54163 AU134061 CR626757 AI572790 AU118569 BM762289 BQ185696 BC023521 BM846072 BQ188252 AK023355 BU500115 BG682171 BE019441 BM848303 BE893256 BC001523 AY463216 CB122531 BQ687021 AL530910 AW080328 BQ073764 BM987297
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for THG1L About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2a | · | 2b | ^ | 3a | · | 3b | · | 3c | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | - | | - | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | - | | - | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for THG1L
|
Expression
for THG1L gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| THG1L expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTTCCTTTGG
About this image
See THG1L Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for THG1L
SOURCE GeneReport for Unigene cluster: Hs.353090
UniProtKB/Swiss-Prot: THG1_HUMAN, Q9NWX6Tissue specificity: Expressed in many tissues
SABiosciences Custom PCR Arrays for THG1L
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for THG1L
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat THG1L | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat THG1L | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat THG1L | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for THG1L |
Orthologs
for THG1L gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for THG1L gene from 9/33 species (see all 33) About this table
ENSEMBL Gene Tree for THG1L (if available)
TreeFam Gene Tree for THG1L (if available) |
Paralogs
for THG1L gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for THG1L gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 5 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for THG1L (157158205 - 157168456 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for THG1L
1 CNV: 3583 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing THG1L |
|
Disorders
/ Diseases
for THG1L gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
THG1L for disorders About GeneDecksing
2  diseases for THG1L: About MalaCardsfibrosis malaria
Human Genome Epidemiology (HuGE) Navigator: THG1L (1 document)
Export disorders for THG1L gene to outside databases
|
Publications
for THG1L gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for THG1L gene, integrated from 9 sources (see all 19):
(articles sorted by number of sources associating them with THG1L) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2, 3 Wiemann S.... Poustka A. (2001)
- Identification and characterization of a novel cytoplasm protein ICF45 that is involved in cell cycle regulation. (PubMed id 15459185)1, 2 Guo D.... He D. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- IHG-1 promotes mitochondrial biogenesis by stabilizin g PGC-1I+. (PubMed id 21784897)1 Hickey F.B....Murphy M. (2011)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- Genome-wide YFP fluorescence complementation screen id entifies new regulators for telomere signaling in human cells. (PubMed id 21044950)1 Lee O.H....Songyang Z. (2011)
|
External Searches for THG1L gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing THG1L gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing THG1L gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing THG1L gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for THG1L | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for THG1L gene:
Search GeneIP for patents involving THG1L
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for THG1L gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for THG1L | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for THG1L | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for THG1L | | | OriGene Protein Over-expression Lysate for THG1L | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for THG1L | | OriGene 3'-UTR Clone for THG1L | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for THG1L | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for THG1L | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for THG1L | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for THG1L | | OriGene Custom Protein Services for THG1L | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat THG1L | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing THG1L | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat THG1L | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat THG1L | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat THG1L | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat THG1L |
| |
 |  |  |  | |
| | | | Search Tocris compounds for THG1L |
| |  |  |  |  | | | | | | Recombinant Protein for THG1L |
|
 |
 |
 |
 | | | THG1L Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for THG1L |
|  |  |  | | | | Search ThermoFisher Antibodies for THG1L |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat THG1L |
|
|
|
|
