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Aliases for THG1L Gene

Aliases for THG1L Gene

  • TRNA-Histidine Guanylyltransferase 1-Like 2 3
  • Interphase Cytoplasmic Foci Protein 45 2 3 4
  • Induced By High Glucose-1 2 3
  • ICF45 3 4
  • TRNA-Histidine Guanylyltransferase 1-Like (S. Cerevisiae) 2
  • TRNA-Histidine Guanylyltransferase 4
  • EC 2.7.7.79 4
  • EC 2.7.7.6 63
  • EC 2.7.7 63
  • IHG-1 3

External Ids for THG1L Gene

Previous GeneCards Identifiers for THG1L Gene

  • GC05P157090
  • GC05P157159
  • GC05P152246

Summaries for THG1L Gene

GeneCards Summary for THG1L Gene

THG1L (TRNA-Histidine Guanylyltransferase 1-Like) is a Protein Coding gene. Among its related pathways are Gene Expression and tRNA modification in the nucleus and cytosol. GO annotations related to this gene include identical protein binding and magnesium ion binding.

UniProtKB/Swiss-Prot for THG1L Gene

  • Adds a GMP to the 5-end of tRNA(His) after transcription and RNase P cleavage. This step is essential for proper recognition of the tRNA and for the fidelity of protein synthesis.

Gene Wiki entry for THG1L Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for THG1L Gene

Genomics for THG1L Gene

Regulatory Elements for THG1L Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for THG1L Gene

Chromosome:
5
Start:
157,731,197 bp from pter
End:
157,741,448 bp from pter
Size:
10,252 bases
Orientation:
Plus strand

Genomic View for THG1L Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
GeneLoc Logo Gene Density

RefSeq DNA sequence for THG1L Gene

Proteins for THG1L Gene

  • Protein details for THG1L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NWX6-THG1_HUMAN
    Recommended name:
    Probable tRNA(His) guanylyltransferase
    Protein Accession:
    Q9NWX6
    Secondary Accessions:
    • D3DQJ5
    • Q53G12
    • Q7L5R3
    • Q9H0S2

    Protein attributes for THG1L Gene

    Size:
    298 amino acids
    Molecular mass:
    34831 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Note=Binds 2 magnesium ions per subunit.;
    Quaternary structure:
    • Homotetramer.
    SequenceCaution:
    • Sequence=AAH01523.2; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH01852.2; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for THG1L Gene

neXtProt entry for THG1L Gene

Proteomics data for THG1L Gene at MOPED

Selected DME Specific Peptides for THG1L Gene

Post-translational modifications for THG1L Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for THG1L Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

Domains & Families for THG1L Gene

Protein Domains for THG1L Gene

Suggested Antigen Peptide Sequences for THG1L Gene

Graphical View of Domain Structure for InterPro Entry

Q9NWX6

UniProtKB/Swiss-Prot:

THG1_HUMAN :
  • Belongs to the tRNA(His) guanylyltransferase family.
Family:
  • Belongs to the tRNA(His) guanylyltransferase family.
genes like me logo Genes that share domains with THG1L: view

No data available for Gene Families for THG1L Gene

Function for THG1L Gene

Molecular function for THG1L Gene

UniProtKB/Swiss-Prot CatalyticActivity:
p-tRNA(His) + ATP + GTP = pppG-P-tRNA(His) + AMP + diphosphate
UniProtKB/Swiss-Prot Function:
Adds a GMP to the 5-end of tRNA(His) after transcription and RNase P cleavage. This step is essential for proper recognition of the tRNA and for the fidelity of protein synthesis.

Enzyme Numbers (IUBMB) for THG1L Gene

Gene Ontology (GO) - Molecular Function for THG1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000049 tRNA binding TAS 21059936
GO:0000287 magnesium ion binding IDA 21059936
GO:0005515 protein binding IPI 25416956
GO:0005524 ATP binding IDA 21059936
GO:0005525 GTP binding IDA 21059936
genes like me logo Genes that share ontologies with THG1L: view

Phenotypes for THG1L Gene

genes like me logo Genes that share phenotypes with THG1L: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for THG1L

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for THG1L Gene

Localization for THG1L Gene

Subcellular locations from UniProtKB/Swiss-Prot for THG1L Gene

Cytoplasm. Note=Found near the nuclear membrane.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for THG1L Gene COMPARTMENTS Subcellular localization image for THG1L gene
Compartment Confidence
mitochondrion 4
nucleus 2

Gene Ontology (GO) - Cellular Components for THG1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IDA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with THG1L: view

Pathways & Interactions for THG1L Gene

genes like me logo Genes that share pathways with THG1L: view

Pathways by source for THG1L Gene

Gene Ontology (GO) - Biological Process for THG1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006400 tRNA modification TAS --
GO:0008033 tRNA processing TAS --
GO:0010467 gene expression TAS --
GO:0051289 protein homotetramerization IPI 21059936
genes like me logo Genes that share ontologies with THG1L: view

No data available for SIGNOR curated interactions for THG1L Gene

Drugs & Compounds for THG1L Gene

(4) Drugs for THG1L Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine monophosphate Approved Nutra 0
Adenosine triphosphate Approved Nutra 0
Diphosphate Experimental Pharma 0
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with THG1L: view

Transcripts for THG1L Gene

Unigene Clusters for THG1L Gene

TRNA-histidine guanylyltransferase 1-like (S. cerevisiae):
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for THG1L

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for THG1L Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b
SP1:
SP2: - -
SP3: - -
SP4:

Relevant External Links for THG1L Gene

GeneLoc Exon Structure for
THG1L
ECgene alternative splicing isoforms for
THG1L

Expression for THG1L Gene

mRNA expression in normal human tissues for THG1L Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for THG1L Gene

This gene is overexpressed in Esophagus (35.4) and Stomach (9.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for THG1L Gene



SOURCE GeneReport for Unigene cluster for THG1L Gene Hs.353090

mRNA Expression by UniProt/SwissProt for THG1L Gene

Q9NWX6-THG1_HUMAN
Tissue specificity: Expressed in many tissues.
genes like me logo Genes that share expression patterns with THG1L: view

Protein tissue co-expression partners for THG1L Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for THG1L Gene

Orthologs for THG1L Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for THG1L Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia THG1L 35
  • 89.37 (n)
  • 89.26 (a)
THG1L 36
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia THG1L 35
  • 89.49 (n)
  • 89.93 (a)
THG1L 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Thg1l 35
  • 83.45 (n)
  • 82.21 (a)
Thg1l 16
Thg1l 36
  • 82 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia THG1L 35
  • 98.99 (n)
  • 98.99 (a)
THG1L 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Thg1l 35
  • 84.75 (n)
  • 85.08 (a)
oppossum
(Monodelphis domestica)
Mammalia THG1L 36
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia THG1L 36
  • 79 (a)
OneToOne
chicken
(Gallus gallus)
Aves THG1L 35
  • 79.06 (n)
  • 84.39 (a)
THG1L 36
  • 79 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia THG1L 36
  • 72 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101733043 35
  • 74.92 (n)
  • 79.44 (a)
Str.13696 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.10272 35
zebrafish
(Danio rerio)
Actinopterygii Dr.16865 35
thg1l 35
  • 70.29 (n)
  • 70.79 (a)
thg1l 36
  • 70 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8574 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011752 35
  • 55.91 (n)
  • 55.51 (a)
fruit fly
(Drosophila melanogaster)
Insecta l(2)35Bc 35
  • 59.08 (n)
  • 58.94 (a)
l(2)35Bc 36
  • 49 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ABR031C 35
  • 52.99 (n)
  • 51.42 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B06237g 35
  • 54.87 (n)
  • 54.25 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes THG1 35
  • 55.19 (n)
  • 52.83 (a)
THG1 36
  • 45 (a)
OneToOne
THG1 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G31580 35
  • 55.51 (n)
  • 47.01 (a)
rice
(Oryza sativa)
Liliopsida Os05g0535500 35
  • 57.66 (n)
  • 49.81 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU02105 35
  • 55.07 (n)
  • 53.04 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPCC63.07 35
  • 55.12 (n)
  • 50.79 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5403 36
  • 49 (a)
OneToOne
Species with no ortholog for THG1L:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for THG1L Gene

ENSEMBL:
Gene Tree for THG1L (if available)
TreeFam:
Gene Tree for THG1L (if available)

Paralogs for THG1L Gene

No data available for Paralogs for THG1L Gene

Variants for THG1L Gene

Sequence variations from dbSNP and Humsavar for THG1L Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
VAR_031871 -

Structural Variations from Database of Genomic Variants (DGV) for THG1L Gene

Variant ID Type Subtype PubMed ID
dgv1868e1 CNV Complex 17122850

Variation tolerance for THG1L Gene

Residual Variation Intolerance Score: 49.44% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.77; 16.31% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for THG1L Gene

HapMap Linkage Disequilibrium report
THG1L

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for THG1L Gene

Disorders for THG1L Gene

Relevant External Links for THG1L

Genetic Association Database (GAD)
THG1L
Human Genome Epidemiology (HuGE) Navigator
THG1L
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
THG1L
genes like me logo Genes that share disorders with THG1L: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for THG1L Gene

Publications for THG1L Gene

  1. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 2 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 67
  4. IHG-1 increases mitochondrial fusion and bioenergetic function. (PMID: 25008184) Hickey F.B. … Murphy M. (Diabetes 2014) 67
  5. Why do cellular proteins linked to K63-polyubiquitin chains not associate with proteasomes? (PMID: 23314748) Nathan J.A. … Goldberg A.L. (EMBO J. 2013) 67

Products for THG1L Gene

Sources for THG1L Gene

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