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Aliases for THG1L Gene

Aliases for THG1L Gene

  • TRNA-Histidine Guanylyltransferase 1-Like (S. Cerevisiae) 2 3
  • Interphase Cytoplasmic Foci Protein 45 2 3 4
  • ICF45 3 4
  • Probable TRNA(His) Guanylyltransferase 3
  • TRNA-Histidine Guanylyltransferase 4
  • Induced By High Glucose-1 3
  • EC 4
  • EC 64
  • EC 2.7.7 64
  • IHG-1 3

External Ids for THG1L Gene

Summaries for THG1L Gene

GeneCards Summary for THG1L Gene

THG1L (TRNA-Histidine Guanylyltransferase 1-Like (S. Cerevisiae)) is a Protein Coding gene. GO annotations related to this gene include identical protein binding and magnesium ion binding.

UniProtKB/Swiss-Prot for THG1L Gene

  • Adds a GMP to the 5-end of tRNA(His) after transcription and RNase P cleavage. This step is essential for proper recognition of the tRNA and for the fidelity of protein synthesis.

Gene Wiki entry for THG1L Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for THG1L Gene

Genomics for THG1L Gene

Genomic Location for THG1L Gene

157,731,197 bp from pter
157,741,448 bp from pter
10,252 bases
Plus strand

Genomic View for THG1L Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for THG1L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for THG1L Gene

Regulatory Elements for THG1L Gene

Proteins for THG1L Gene

  • Protein details for THG1L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Probable tRNA(His) guanylyltransferase
    Protein Accession:
    Secondary Accessions:
    • D3DQJ5
    • Q53G12
    • Q7L5R3
    • Q9H0S2

    Protein attributes for THG1L Gene

    298 amino acids
    Molecular mass:
    34831 Da
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Note=Binds 2 magnesium ions per subunit.;
    Quaternary structure:
    • Homotetramer.
    • Sequence=AAH01523.2; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH01852.2; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for THG1L Gene

neXtProt entry for THG1L Gene

Proteomics data for THG1L Gene at MOPED

Selected DME Specific Peptides for THG1L Gene

Post-translational modifications for THG1L Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for THG1L Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains for THG1L Gene

Protein Domains for THG1L Gene


  • Belongs to the tRNA(His) guanylyltransferase family.:
    • Q9NWX6
genes like me logo Genes that share domains with THG1L: view

No data available for Gene Families for THG1L Gene

Function for THG1L Gene

Molecular function for THG1L Gene

UniProtKB/Swiss-Prot CatalyticActivity: p-tRNA(His) + ATP + GTP = pppG-P-tRNA(His) + AMP + diphosphate
UniProtKB/Swiss-Prot Function: Adds a GMP to the 5-end of tRNA(His) after transcription and RNase P cleavage. This step is essential for proper recognition of the tRNA and for the fidelity of protein synthesis.

Enzyme Numbers (IUBMB) for THG1L Gene

Gene Ontology (GO) - Molecular Function for THG1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000049 tRNA binding TAS 21059936
GO:0000287 magnesium ion binding IDA 21059936
GO:0005515 protein binding IPI 25416956
GO:0005524 ATP binding IDA 21059936
GO:0005525 GTP binding IDA 21059936
genes like me logo Genes that share ontologies with THG1L: view

miRNA for THG1L Gene

miRTarBase miRNAs that target THG1L

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for THG1L Gene

Localization for THG1L Gene

Subcellular locations from UniProtKB/Swiss-Prot for THG1L Gene

Cytoplasm. Note=Found near the nuclear membrane.

Subcellular locations from

Jensen Localization Image for THG1L Gene COMPARTMENTS Subcellular localization image for THG1L gene
Compartment Confidence
mitochondrion 4
cytosol 2
endoplasmic reticulum 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for THG1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm ISS --
GO:0005739 mitochondrion IDA --
genes like me logo Genes that share ontologies with THG1L: view

Pathways for THG1L Gene

SuperPathways for THG1L Gene

No Data Available

Gene Ontology (GO) - Biological Process for THG1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006400 tRNA modification ISS --
GO:0008033 tRNA processing IDA 21059936
GO:0051289 protein homotetramerization IPI 21059936
genes like me logo Genes that share ontologies with THG1L: view

No data available for Pathways by source for THG1L Gene

Transcripts for THG1L Gene

Unigene Clusters for THG1L Gene

TRNA-histidine guanylyltransferase 1-like (S. cerevisiae):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for THG1L Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b
SP2: - -
SP3: - -

Relevant External Links for THG1L Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for THG1L Gene

mRNA expression in normal human tissues for THG1L Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for THG1L Gene

SOURCE GeneReport for Unigene cluster for THG1L Gene Hs.353090

mRNA Expression by UniProt/SwissProt for THG1L Gene

Tissue specificity: Expressed in many tissues.
genes like me logo Genes that share expressions with THG1L: view

Orthologs for THG1L Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for THG1L Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia THG1L 36
  • 98.99 (n)
  • 98.99 (a)
THG1L 37
  • 99 (a)
(Bos Taurus)
Mammalia THG1L 36
  • 89.37 (n)
  • 89.26 (a)
THG1L 37
  • 89 (a)
(Canis familiaris)
Mammalia THG1L 36
  • 89.49 (n)
  • 89.93 (a)
THG1L 37
  • 90 (a)
(Mus musculus)
Mammalia Thg1l 36
  • 83.45 (n)
  • 82.21 (a)
Thg1l 16
Thg1l 37
  • 82 (a)
(Monodelphis domestica)
Mammalia THG1L 37
  • 81 (a)
(Ornithorhynchus anatinus)
Mammalia THG1L 37
  • 79 (a)
(Rattus norvegicus)
Mammalia Thg1l 36
  • 84.75 (n)
  • 85.08 (a)
(Gallus gallus)
Aves THG1L 36
  • 79.06 (n)
  • 84.39 (a)
THG1L 37
  • 79 (a)
(Anolis carolinensis)
Reptilia THG1L 37
  • 72 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.10272 36
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101733043 36
  • 74.92 (n)
  • 79.44 (a)
Str.13696 36
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8574 36
(Danio rerio)
Actinopterygii Dr.16865 36
thg1l 36
  • 70.29 (n)
  • 70.79 (a)
thg1l 37
  • 70 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011752 36
  • 55.91 (n)
  • 55.51 (a)
fruit fly
(Drosophila melanogaster)
Insecta l(2)35Bc 36
  • 59.08 (n)
  • 58.94 (a)
l(2)35Bc 37
  • 49 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ABR031C 36
  • 52.99 (n)
  • 51.42 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes THG1 36
  • 55.19 (n)
  • 52.83 (a)
THG1 37
  • 45 (a)
THG1 39
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B06237g 36
  • 54.87 (n)
  • 54.25 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G31580 36
  • 55.51 (n)
  • 47.01 (a)
(Oryza sativa)
Liliopsida Os05g0535500 36
  • 57.66 (n)
  • 49.81 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU02105 36
  • 55.07 (n)
  • 53.04 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPCC63.07 36
  • 55.12 (n)
  • 50.79 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5403 37
  • 49 (a)
Species with no ortholog for THG1L:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for THG1L Gene

Gene Tree for THG1L (if available)
Gene Tree for THG1L (if available)

Paralogs for THG1L Gene

No data available for Paralogs for THG1L Gene

Variants for THG1L Gene

Sequence variations from dbSNP and Humsavar for THG1L Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs2270812 - 157,737,954(-) TCGGC(A/G)GCTCA missense, reference
rs2270813 -- 157,737,881(-) CTGAG(A/G)AAATA intron-variant
rs2270814 -- 157,737,727(-) GCAAT(G/T)ATGAT intron-variant
rs2270815 -- 157,737,576(-) CAAGG(C/T)TAAAA intron-variant
rs2270816 -- 157,731,693(-) CAAGG(C/G)AAGAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for THG1L Gene

Variant ID Type Subtype PubMed ID
dgv1868e1 CNV Complex 17122850

Relevant External Links for THG1L Gene

HapMap Linkage Disequilibrium report

Disorders for THG1L Gene

Relevant External Links for THG1L

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with THG1L: view

No data available for UniProtKB/Swiss-Prot for THG1L Gene

Publications for THG1L Gene

  1. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 2 3 4
  2. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 49
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. Identification and characterization of a novel cytoplasm protein ICF45 that is involved in cell cycle regulation. (PMID: 15459185) Guo D. … He D. (J. Biol. Chem. 2004) 3 4
  5. tRNA(His) guanylyltransferase (THG1), a unique 3'-5' nucleotidyl transferase, shares unexpected structural homology with canonical 5'- 3' DNA polymerases. (PMID: 21059936) Hyde S.J. … Doublie S. (Proc. Natl. Acad. Sci. U.S.A. 2010) 3 4

Products for THG1L Gene

Sources for THG1L Gene

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