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Aliases for THEMIS2 Gene

Aliases for THEMIS2 Gene

  • Thymocyte Selection Associated Family Member 2 2 3
  • Thymocyte-Expressed Molecule Involved In Selection Protein 2 3 4
  • Induced By Contact To Basement Membrane 1 Protein 3 4
  • Protein ICB-1 3 4
  • C1orf38 3 4
  • Induced By Contact To Basement Membrane 1 2
  • Chromosome 1 Open Reading Frame 38 2
  • Basement Membrane-Induced 3
  • Protein THEMIS2 3
  • ICB-1 3
  • ICB1 4

External Ids for THEMIS2 Gene

Previous HGNC Symbols for THEMIS2 Gene

  • C1orf38

Previous GeneCards Identifiers for THEMIS2 Gene

  • GC01P028200

Summaries for THEMIS2 Gene

GeneCards Summary for THEMIS2 Gene

THEMIS2 (Thymocyte Selection Associated Family Member 2) is a Protein Coding gene. Diseases associated with THEMIS2 include endometrial adenocarcinoma.

UniProtKB/Swiss-Prot for THEMIS2 Gene

  • May constitute a control point in macrophage inflammatory response, promoting LPS-induced TNF production.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for THEMIS2 Gene

Genomics for THEMIS2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for THEMIS2 Gene

Start:
27,872,543 bp from pter
End:
27,886,685 bp from pter
Size:
14,143 bases
Orientation:
Plus strand

Genomic View for THEMIS2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for THEMIS2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for THEMIS2 Gene

No data available for Regulatory Elements for THEMIS2 Gene

Proteins for THEMIS2 Gene

  • Protein details for THEMIS2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5TEJ8-THMS2_HUMAN
    Recommended name:
    Protein THEMIS2
    Protein Accession:
    Q5TEJ8
    Secondary Accessions:
    • A2RTZ3
    • B4DZT9
    • B4DZY3
    • O60560
    • Q5TEJ1
    • Q5TEJ9
    • Q5TEK1
    • Q68DP4
    • Q9BYB6
    • Q9NS90

    Protein attributes for THEMIS2 Gene

    Size:
    643 amino acids
    Molecular mass:
    72049 Da
    Quaternary structure:
    • When phosphorylated, interacts with LYN. Interacts with VAV1 and GRB2 (By similarity).
    SequenceCaution:
    • Sequence=AAC16284.1; Type=Frameshift; Positions=416, 469, 494, 530, 532; Evidence={ECO:0000305}; Sequence=BAA96464.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB33313.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAG64201.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAI21769.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI21771.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI21773.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for THEMIS2 Gene

neXtProt entry for THEMIS2 Gene

Proteomics data for THEMIS2 Gene at MOPED

Post-translational modifications for THEMIS2 Gene

No data available for DME Specific Peptides for THEMIS2 Gene

Domains for THEMIS2 Gene

Protein Domains for THEMIS2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for THEMIS2 Gene

Graphical View of Domain Structure for InterPro Entry

Q5TEJ8

UniProtKB/Swiss-Prot:

THMS2_HUMAN :
  • Q5TEJ8
Family:
  • Belongs to the themis family.
genes like me logo Genes that share domains with THEMIS2: view

No data available for Gene Families for THEMIS2 Gene

Function for THEMIS2 Gene

Molecular function for THEMIS2 Gene

UniProtKB/Swiss-Prot Function: May constitute a control point in macrophage inflammatory response, promoting LPS-induced TNF production.
UniProtKB/Swiss-Prot Induction: By contact to a reconstituted basement membrane

Gene Ontology (GO) - Molecular Function for THEMIS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with THEMIS2: view

Phenotypes for THEMIS2 Gene

MGI mutant phenotypes for THEMIS2:
inferred from 1 alleles
genes like me logo Genes that share phenotypes with THEMIS2: view

Animal Model Products

CRISPR Products

miRNA for THEMIS2 Gene

miRTarBase miRNAs that target THEMIS2

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for THEMIS2 Gene

Localization for THEMIS2 Gene

Gene Ontology (GO) - Cellular Components for THEMIS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with THEMIS2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from COMPARTMENTS for THEMIS2 Gene

Pathways for THEMIS2 Gene

SuperPathways for THEMIS2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for THEMIS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006954 inflammatory response IEA --
GO:0007155 cell adhesion TAS 9563507
GO:0050852 T cell receptor signaling pathway IEA --
genes like me logo Genes that share ontologies with THEMIS2: view

No data available for Pathways by source for THEMIS2 Gene

Transcripts for THEMIS2 Gene

Unigene Clusters for THEMIS2 Gene

Thymocyte selection associated family member 2:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for THEMIS2

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for THEMIS2 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b · 4c · 4d ^ 5 ^ 6a · 6b ^ 7a · 7b
SP1: - - - -
SP2: - - - - - -
SP3: - - - - - - - - -
SP4: - -
SP5:
SP6: -
SP7: - - -
SP8: -
SP9:
SP10: -

Relevant External Links for THEMIS2 Gene

GeneLoc Exon Structure for
THEMIS2
ECgene alternative splicing isoforms for
THEMIS2

Expression for THEMIS2 Gene

mRNA expression in normal human tissues for THEMIS2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for THEMIS2 Gene

This gene is overexpressed in Whole Blood (25.9) and Spleen (5.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for THEMIS2 Gene

SOURCE GeneReport for Unigene cluster for THEMIS2 Gene Hs.10649

mRNA Expression by UniProt/SwissProt for THEMIS2 Gene

Q5TEJ8-THMS2_HUMAN
Tissue specificity: Expressed in different endometrial adenocarcinoma cell lines and various other cell lines apart from the prostate cell line LNCaP and the ovarian cancer cell line BG1.
genes like me logo Genes that share expressions with THEMIS2: view

In Situ Assay Products

Orthologs for THEMIS2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for THEMIS2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia THEMIS2 35
  • 99.07 (n)
  • 98.44 (a)
THEMIS2 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia THEMIS2 35
  • 81.02 (n)
  • 71.61 (a)
THEMIS2 36
  • 68 (a)
OneToOne
dog
(Canis familiaris)
Mammalia THEMIS2 35
  • 82.01 (n)
  • 74.26 (a)
THEMIS2 36
  • 73 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Themis2 35
  • 77.69 (n)
  • 69.62 (a)
Themis2 16
Themis2 36
  • 66 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia THEMIS2 36
  • 46 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Themis2 35
  • 77 (n)
  • 70.59 (a)
chicken
(Gallus gallus)
Aves C23H1ORF38 35
  • 60.03 (n)
  • 51.34 (a)
THEMIS2 36
  • 41 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia THEMIS2 36
  • 35 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia themis2 35
  • 48.23 (n)
  • 38.55 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC100535600 35
  • 47.37 (n)
  • 38.87 (a)
themis2 36
  • 36 (a)
OneToOne
Species with no ortholog for THEMIS2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for THEMIS2 Gene

ENSEMBL:
Gene Tree for THEMIS2 (if available)
TreeFam:
Gene Tree for THEMIS2 (if available)

Paralogs for THEMIS2 Gene

Selected SIMAP similar genes for THEMIS2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with THEMIS2: view

No data available for Paralogs for THEMIS2 Gene

Variants for THEMIS2 Gene

Sequence variations from dbSNP and Humsavar for THEMIS2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs6564 -- 27,886,464(-) GCCAA(A/G)TTCCC utr-variant-3-prime
rs6565 -- 27,886,646(-) ATTCT(A/G)TGGTT utr-variant-3-prime
rs11399 -- 27,886,295(+) TCACA(C/T)TGCAT utr-variant-3-prime
rs11485 -- 27,886,368(+) CCTGG(A/C)CTGTC utr-variant-3-prime
rs14455 -- 27,886,562(+) TGAGG(A/C)TGCAG utr-variant-3-prime

Relevant External Links for THEMIS2 Gene

HapMap Linkage Disequilibrium report
THEMIS2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for THEMIS2 Gene

Disorders for THEMIS2 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for THEMIS2 Gene including...

Search for THEMIS2 Gene in MalaCards »
genes like me logo Genes that share disorders with THEMIS2: view

No data available for UniProtKB/Swiss-Prot for THEMIS2 Gene

Publications for THEMIS2 Gene

  1. A novel basement membrane-induced gene identified in the human endometrial adenocarcinoma cell line HEC1B. (PMID: 9563507) Treeck O. … Vollmer G. (FEBS Lett. 1998) 3 4 23
  2. Expression of icb-1 gene is interferon-gamma inducible in breast and ovarian cancer cell lines and affects the IFN gamma-response of SK-OV-3 ovarian cancer cells. (PMID: 16219472) Treeck O. … Ortmann O. (Cytokine 2005) 2 3 23
  3. Detection of increased icb-1 transcript levels in maturing HL-60 cells: a novel marker for granulocytic and monocytic in vitro differentiation. (PMID: 12191572) Treeck O. … Vollmer G. (Leuk. Res. 2002) 3 23
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for THEMIS2 Gene

Sources for THEMIS2 Gene

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