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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

THEMIS2 Gene

protein-coding   GIFtS: 41
GCID: GC01P028200

thymocyte selection associated family member 2

(Previous name: chromosome 1 open reading frame 38 )
(Previous symbol: C1orf38)
 Explore 7 diseases affiliated with
THEMIS2 via our new
 Human Malady Compendium 
Biological research products
for THEMIS2
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Thymocyte Selection Associated Family Member 21 2     Icb-11
C1orf381 2 3     Chromosome 1 Open Reading Frame 381
ICB-11 2     Basement Membrane-Induced2
Induced By Contact To Basement Membrane 1 Protein2 3     Protein THEMIS22
Protein ICB-12 3     ICB13
Thymocyte-Expressed Molecule Involved In Selection Protein 22 3     

External Ids:    HGNC: 168391   Entrez Gene: 94732   Ensembl: ENSG000001307757   UniProtKB: Q5TEJ83   

Export aliases for THEMIS2 gene to outside databases


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: THMS2_HUMAN, Q5TEJ8
Function: May constitute a control point in macrophage inflammatory response, promoting LPS-induced TNF production




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_004610.19  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for THEMIS2
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for THEMIS2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat THEMIS2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p35.3   Ensembl cytogenetic band:  1p35.3   HGNC cytogenetic band: 1p35.2

THEMIS2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
THEMIS2 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P028200:  view genomic region     (about GC identifiers)

Start:
28,199,055 bp from pter      End:
28,213,196 bp from pter
Size:
14,142 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: THMS2_HUMAN, Q5TEJ8 (See protein sequence)
Recommended Name: Protein THEMIS2  
Size: 643 amino acids; 72049 Da
Subunit: When phosphorylated, interacts with LYN. Interacts with VAV1 and GRB2 (By similarity)
Sequence caution: Sequence=AAC16284.1; Type=Frameshift; Positions=416, 469, 494, 530, 532; Sequence=BAA96464.1;
Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAB33313.1; Type=Erroneous initiation;
Note=Translation N-terminally extended; Sequence=BAG64201.1; Type=Erroneous initiation; Note=Translation N-terminally
extended; Sequence=CAI21769.1; Type=Erroneous gene model prediction; Sequence=CAI21771.1; Type=Erroneous gene model
prediction; Sequence=CAI21773.1; Type=Erroneous gene model prediction;
Secondary accessions: A2RTZ3 B4DZT9 B4DZY3 O60560 Q5TEJ1 Q5TEJ9 Q5TEK1 Q68DP4 Q9BYB6 Q9NS90
Alternative splicing: 6 isoforms:  Q5TEJ8-1   Q5TEJ8-2   Q5TEJ8-3   Q5TEJ8-4   Q5TEJ8-5   Q5TEJ8-6   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for THEMIS2: NX_Q5TEJ8

Post-translational modifications:

  • Phosphorylation at Tyr-632 is induced by LPS (By similarity)1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q5TEJ8

  • THEMIS2 Protein expression data from MOPED and PaxDb:    About this image 
    THEMIS2 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001034566.1  NP_001099026.1  NP_004839.2  

    ENSEMBL proteins: 
     ENSP00000363035   ENSP00000363037   ENSP00000392414   ENSP00000413725   ENSP00000363031  
     ENSP00000398049   ENSP00000329862  

    Human Recombinant Protein Products for THEMIS2: 
    Browse Purified and Recombinant Proteins at EMD Millipore
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    OriGene Purified Protein: THEMIS2
    OriGene Protein Over-expression Lysate: THEMIS2
    OriGene Custom Protein Services for THEMIS2 
    GenScript Custom Purified and Recombinant Proteins Services for THEMIS2
    Novus Biologicals THEMIS2 Protein
    Novus Biologicals THEMIS2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for THEMIS2


    THEMIS2 Antibody Products: 
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    OriGene Custom Antibody Services for THEMIS2 
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    Novus Biologicals THEMIS2 Antibodies
    Abcam antibodies for THEMIS2 
    Uscn Antibodies for THEMIS2
    ThermoFisher Antibodies for THEMIS2

    Assay Products for THEMIS2: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for THEMIS2
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for THEMIS2


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    THEMIS2 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR025946 CABIT_dom

    Graphical View of Domain Structure for InterPro Entry Q5TEJ8

    ProtoNet protein and cluster: Q5TEJ8

    UniProtKB/Swiss-Prot: THMS2_HUMAN, Q5TEJ8
    Similarity: Belongs to the themis family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: THMS2_HUMAN, Q5TEJ8
    Function: May constitute a control point in macrophage inflammatory response, promoting LPS-induced TNF production
    Induction: By contact to a reconstituted basement membrane

    Phenotypes:
         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Themis2):

     cellular 

    THEMIS2 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for THEMIS2 

    miRNA
    Products:
        
    miRTarBase miRNAs that target THEMIS2:
    hsa-mir-197 (MIRT004216)

    OriGene 3'-UTR Clone (see all 3): THEMIS2
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat THEMIS2
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate THEMIS2
    SwitchGear 3'UTR luciferase reporter plasmidTHEMIS2 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for THEMIS2 (see all 4)
    OriGene shRNA RFP: THEMIS2
    OriGene siRNA: THEMIS2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat THEMIS2
    Sirion Biotech Custom design and validation of potent shRNA sequences against THEMIS2 

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for THEMIS2
    Sirion Biotech Customized adenovirus for overexpression of THEMIS2 
    Sirion Biotech Customized adenovirus for potent knockdown of THEMIS2

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for THEMIS2 (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for THEMIS2 (see all 3)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript Custom all cDNA clones Services for THEMIS2
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for THEMIS2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat THEMIS2 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for THEMIS2
    Search LifeMap BioReagents cell lines for THEMIS2
    Sirion Biotech Customized stable knockdown cell line services for THEMIS2 
    Sirion Biotech Customized inducible knockdown cell line services for THEMIS2
    Sirion Biotech Customized stable overexpressing cell line services for THEMIS2
    Sirion Biotech Customized inducible overexpressing cell line services for THEMIS2

    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for THEMIS2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for THEMIS2

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    4 Interacting proteins for THEMIS2 (ENSP000003630314) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CRYZENSP000003393994STRING: ENSP00000339399
    NBL1ENSP000002897494STRING: ENSP00000289749
    --ENSP000004031544STRING: ENSP00000403154
    --ENSP000003728604STRING: ENSP00000372860
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006954inflammatory response IEA--
    GO:0007155cell adhesion TAS9563507

    THEMIS2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for THEMIS2
    Search CenterWatch for drugs/clinical trials and news about THEMIS2 / THMS2 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for THEMIS2 gene (3 alternative transcripts): 
    NM_001039477.1  NM_001105556.1  NM_004848.2  

    Unigene Cluster for THEMIS2:

    Thymocyte selection associated family member 2
    Hs.10649  [show with all ESTs]
    Unigene Representative Sequence: NM_001105556
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000373925(uc001bpa.3 uc001boz.3) ENST00000373927 ENST00000427466
    ENST00000442118 ENST00000467258 ENST00000373921(uc001bpc.4 uc010ofn.2)
    ENST00000466068 ENST00000482828 ENST00000456990 ENST00000492877 ENST00000328928(uc010ofo.2)


    miRNA
    Products:
         
    OriGene 3'-UTR Clone (see all 3): THEMIS2
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat THEMIS2
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate THEMIS2
    SwitchGear 3'UTR luciferase reporter plasmidTHEMIS2 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for THEMIS2 (see all 4)
    OriGene shRNA RFP: THEMIS2
    OriGene siRNA: THEMIS2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat THEMIS2
    Sirion Biotech Custom design and validation of potent shRNA sequences against THEMIS2 
    Clone
    Products:
         
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for THEMIS2 (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for THEMIS2 (see all 3)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript Custom all cDNA clones Services for THEMIS2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for THEMIS2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat THEMIS2 
    Primer
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    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for THEMIS2
    Browse OriGene validated miRNA SYBR primer pairs
    Search SABiosciences RT2 qPCR Primer Assays in human, mouse, rat THEMIS2
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat THEMIS2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat THEMIS2

    Additional cDNA sequence: 

    AB035482.1 AB050854.1 AF323721.1 AK303090.1 AK303141.1 AK309633.1 BC031655.1 BC132692.1 
    BC133049.1 CR749321.1 

    10 DOTS entries:

    DT.100783005  DT.95110258  DT.95110255  DT.92066684  DT.100719017  DT.121404031  DT.416836  DT.100783006 
    DT.86847619  DT.91746611 

    24/181 AceView cDNA sequences (see all 181):

    AL551609 BM473038 CA308421 CR604917 BI823781 AA588624 AB035482 AK094833 
    BM708753 AA575924 N33211 BM922210 W63743 AW193256 AA280149 AW518359 
    AI927451 AI866718 BP339331 AI570737 CB528870 AA455658 CD365001 BV178317 

    GeneLoc Exon Structure

    5/10 Alternative Splicing Database (ASD) splice patterns (SP) for THEMIS2 (see all 10)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b · 4c · 4d ^ 5 ^ 6a · 6b ^ 7a · 7b
    SP1:                                                        -     -     -           -                     
    SP2:                                                  -     -     -     -     -     -                     
    SP3:                                -     -     -     -     -     -     -     -     -                     
    SP4:                                -     -                                                               
    SP5:                                                                                                      


    ECgene alternative splicing isoforms for THEMIS2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section
    See probesets specificity/sensitivity at GeneAnnot
    CGAP TAG: --

    See THEMIS2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for THEMIS2

    SOURCE GeneReport for Unigene cluster: Hs.10649

    UniProtKB/Swiss-Prot: THMS2_HUMAN, Q5TEJ8
    Tissue specificity: Expressed in different endometrial adenocarcinoma cell lines and various other cell lines apart
    from the prostate cell line LNCaP and the ovarian cancer cell line BG1

        SABiosciences Custom PCR Arrays for THEMIS2
    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat THEMIS2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for THEMIS2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for THEMIS2 gene from 3/9 species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves C23H1orf381 chromosome 23 open reading frame, human C1orf38 59.46(n)
    50.86(a)
      419565  XM_417712.2  XP_417712.2 
    lizard
    (Anolis carolinensis)
    Reptilia C1orf386
    --
    36(a)
    1 ↔ 1
    GL343743.1(40828-48702)
    zebrafish
    (Danio rerio)
    Actinopterygii si:ch1073-55d10.26
    si:ch1073-55d10.2
    38(a)
    1 ↔ 1
    16(5670563-5683375)


    ENSEMBL Gene Tree for THEMIS2 (if available)
    TreeFam Gene Tree for THEMIS2 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for THEMIS2 gene
    THEMIS2  
    1 SIMAP similar gene for THEMIS2 using alignment to 3 protein entries:     THMS2_HUMAN (see all proteins):
    THEMIS

    THEMIS2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/327 NCBI SNPs in THEMIS2 are shown (see all 327    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs607934871,2
    F--28197119(+) TGGAGT/GGCAGT 3 -- us2k12Minor allele frequency- G:0.12NA EA 240
    rs1459088471,2
    --28197120(+) GGAGTA/GCAGTG 3 -- us2k10--------
    rs1384603531,2
    --28197186(+) CTCAGA/TCTCCT 3 -- us2k10--------
    rs1402406481,2
    --28197246(+) ATTTAC/TTTATT 3 -- us2k10--------
    rs1451949231,2
    --28197300(+) CTGGAA/GTAAAG 3 -- us2k10--------
    rs1929126611,2
    --28197317(+) GATCTC/TGGCTC 3 -- us2k10--------
    rs350737601,2
    C--28197336(+) CTCTG-/CCCCCC 3 -- us2k10--------
    rs112476971,2
    C,A,H--28197454(+) TTGTTA/GCCCAA 3 -- us2k13Minor allele frequency- G:0.15NA CSA 125
    rs112476981,2
    C,A,H--28197517(+) TCAAGC/TGATTC 3 -- us2k11Minor allele frequency- T:0.50CSA 2
    rs1851279281,2
    --28197633(+) GGTCTC/GGAACT 3 -- us2k10--------

    HapMap Linkage Disequilibrium report for THEMIS2 (28199055 - 28213196 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for THEMIS2: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing THEMIS2
    DNA2.0 Custom Variant and Variant Library Synthesis for THEMIS2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    THEMIS2 for disorders           About GeneDecksing

    7 diseases for THEMIS2:    About MalaCards
    endometrial adenocarcinoma    breast-ovarian cancer    ovarian cancer    breast cancer
    breast cancer susceptibility    adenocarcinoma    prostatitis


    Export disorders for THEMIS2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for THEMIS2 gene, integrated from 9 sources (see all 17):
    (articles sorted by number of sources associating them with THEMIS2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Expression of icb-1 gene is interferon-gamma inducible in breast and ovarian cancer cell lines and affects the IFN gamma-response of SK-OV-3 ovarian cancer cells. (PubMed id 16219472)1, 3, 9 Treeck O....Ortmann O. (2005)
    2. A novel basement membrane-induced gene identified in the human endometrial adenocarcinoma cell line HEC1B. (PubMed id 9563507)1, 2, 9 Treeck O.... Vollmer G. (1998)
    3. Themis2/ICB1 is a signaling scaffold that selectively regulates macrophage Toll-like receptor signaling and cytokine production. (PubMed id 20644716)1, 2 Peirce M.J.... Wait R. (2010)
    4. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    7. Knockdown of ICB-1 gene enhanced estrogen responsiven ess of ovarian and breast cancer cells. (PubMed id 19942713)1, 9 Konwisorz A....Treeck O. (2010)
    8. Detection of increased icb-1 transcript levels in maturing HL-60 cells: a novel marker for granulocytic and monocytic in vitro differentiation. (PubMed id 12191572)1, 9 Treeck O....Vollmer G. (2002)
    9. Single Nucleotide Polymorphisms in Human Gene icb-1 and Breast Cancer Susceptibility. (PubMed id 19308812)1, 9 Springwald A....Treeck O. (2009)
    10. Network analysis of icb-1 gene function in human breas t cancer cells. (PubMed id 22565810)1 Treeck O....Ortmann O. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9473 HGNC: 16839 AceView: C1orf38 Ensembl:ENSG00000130775 euGenes: HUgn9473
    ECgene: THEMIS2 H-InvDB: THEMIS2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for THEMIS2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for THEMIS2 gene:
    Search GeneIP for patents involving THEMIS2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
    About This Section

     
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     THEMIS2 Proteins, Antibodies, CLIAs, and ELISAs
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    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013 , 13 May 2013

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