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Aliases for THEMIS2 Gene

Aliases for THEMIS2 Gene

  • Thymocyte Selection Associated Family Member 2 2 3 5
  • Thymocyte-Expressed Molecule Involved In Selection Protein 2 3 4
  • Induced By Contact To Basement Membrane 1 Protein 3 4
  • Protein ICB-1 3 4
  • C1orf38 3 4
  • Induced By Contact To Basement Membrane 1 2
  • Chromosome 1 Open Reading Frame 38 2
  • Basement Membrane-Induced 3
  • Protein THEMIS2 3
  • ICB-1 3
  • ICB1 4

External Ids for THEMIS2 Gene

Previous HGNC Symbols for THEMIS2 Gene

  • C1orf38

Previous GeneCards Identifiers for THEMIS2 Gene

  • GC01P028200

Summaries for THEMIS2 Gene

GeneCards Summary for THEMIS2 Gene

THEMIS2 (Thymocyte Selection Associated Family Member 2) is a Protein Coding gene. Diseases associated with THEMIS2 include Endometrial Adenocarcinoma. An important paralog of this gene is THEMIS.

UniProtKB/Swiss-Prot for THEMIS2 Gene

  • May constitute a control point in macrophage inflammatory response, promoting LPS-induced TNF production.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for THEMIS2 Gene

Genomics for THEMIS2 Gene

Regulatory Elements for THEMIS2 Gene

Enhancers for THEMIS2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G027941 1.7 FANTOM5 Ensembl ENCODE 29.8 +70.6 70617 3.1 HDGF PKNOX1 FOXA2 ATF1 MLX ZFP64 ARID4B DMAP1 YY1 TCF12 SMPDL3B THEMIS2 PTAFR FGR XKR8 RPA2 SESN2 MED18 EYA3 WASF2
GH01G027871 1.7 FANTOM5 ENCODE dbSUPER 26.9 +2.1 2081 5.3 HDGF PKNOX1 ATF1 CREB3L1 WRNIP1 SIN3A FEZF1 GTF3C2 ZNF143 ZNF207 FGR THEMIS2 RPA2 XKR8 EYA3 GMEB1 PHACTR4 PTAFR SNHG12 ACTG1P20
GH01G027881 1.8 FANTOM5 Ensembl ENCODE dbSUPER 22.3 +15.3 15268 11.7 HDGF PKNOX1 ARNT ZNF121 ZNF143 JUNB REST TBX21 ZNF592 SREBF1 RPA2 XKR8 THEMIS2 SMPDL3B ENSG00000227050 EYA3 SCARNA1 PPP1R8 RNU6-1245P FGR
GH01G027614 2.1 FANTOM5 Ensembl ENCODE dbSUPER 17.5 -246.7 -246706 23.4 MLX ZFP64 DMAP1 YBX1 FEZF1 YY1 ZNF143 ZNF263 SP3 MCM3 FGR ACTG1P20 THEMIS2 ENSG00000225886 XKR8 FAM76A TMEM222 RNU6-48P TRNAU1AP RPA2
GH01G028135 1.7 FANTOM5 Ensembl ENCODE dbSUPER 21.4 +263.3 263327 1.7 BCOR ZMYM3 CEBPG TCF12 ZNF316 ADNP MAFK SMARCA5 NR2F1 CEBPB THEMIS2 ENSG00000270605 PTAFR XKR8 PHACTR4 MED18 SESN2 EYA3 STX12 FAM76A
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around THEMIS2 on UCSC Golden Path with GeneCards custom track

Promoters for THEMIS2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000003787 457 1601 HDGF PKNOX1 CREB3L1 GTF3C2 ZNF143 ZNF207 ZNF263 JUNB TBX21 SMARCA4

Genomic Location for THEMIS2 Gene

Chromosome:
1
Start:
27,872,543 bp from pter
End:
27,886,685 bp from pter
Size:
14,143 bases
Orientation:
Plus strand

Genomic View for THEMIS2 Gene

Genes around THEMIS2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
THEMIS2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for THEMIS2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for THEMIS2 Gene

Proteins for THEMIS2 Gene

  • Protein details for THEMIS2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5TEJ8-THMS2_HUMAN
    Recommended name:
    Protein THEMIS2
    Protein Accession:
    Q5TEJ8
    Secondary Accessions:
    • A2RTZ3
    • B4DZT9
    • B4DZY3
    • O60560
    • Q5TEJ1
    • Q5TEJ9
    • Q5TEK1
    • Q68DP4
    • Q9BYB6
    • Q9NS90

    Protein attributes for THEMIS2 Gene

    Size:
    643 amino acids
    Molecular mass:
    72049 Da
    Quaternary structure:
    • When phosphorylated, interacts with LYN. Interacts with VAV1 and GRB2 (By similarity).
    SequenceCaution:
    • Sequence=AAC16284.1; Type=Frameshift; Positions=416, 469, 494, 530, 532; Evidence={ECO:0000305}; Sequence=BAA96464.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB33313.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAG64201.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAI21769.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI21771.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI21773.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for THEMIS2 Gene

neXtProt entry for THEMIS2 Gene

Post-translational modifications for THEMIS2 Gene

No data available for DME Specific Peptides for THEMIS2 Gene

Domains & Families for THEMIS2 Gene

Protein Domains for THEMIS2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for THEMIS2 Gene

Graphical View of Domain Structure for InterPro Entry

Q5TEJ8

UniProtKB/Swiss-Prot:

THMS2_HUMAN :
  • Belongs to the themis family.
Family:
  • Belongs to the themis family.
genes like me logo Genes that share domains with THEMIS2: view

No data available for Gene Families for THEMIS2 Gene

Function for THEMIS2 Gene

Molecular function for THEMIS2 Gene

UniProtKB/Swiss-Prot Function:
May constitute a control point in macrophage inflammatory response, promoting LPS-induced TNF production.
UniProtKB/Swiss-Prot Induction:
By contact to a reconstituted basement membrane.

Gene Ontology (GO) - Molecular Function for THEMIS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with THEMIS2: view
genes like me logo Genes that share phenotypes with THEMIS2: view

Animal Models for THEMIS2 Gene

MGI Knock Outs for THEMIS2:

Animal Model Products

CRISPR Products

miRNA for THEMIS2 Gene

miRTarBase miRNAs that target THEMIS2

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for THEMIS2 Gene

Localization for THEMIS2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for THEMIS2 gene
Compartment Confidence
nucleus 3
golgi apparatus 3
cytosol 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for THEMIS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with THEMIS2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for THEMIS2 Gene

Pathways & Interactions for THEMIS2 Gene

SuperPathways for THEMIS2 Gene

No Data Available

Interacting Proteins for THEMIS2 Gene

Gene Ontology (GO) - Biological Process for THEMIS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006954 inflammatory response IEA --
GO:0007155 cell adhesion TAS 9563507
GO:0050852 T cell receptor signaling pathway IEA --
genes like me logo Genes that share ontologies with THEMIS2: view

No data available for Pathways by source and SIGNOR curated interactions for THEMIS2 Gene

Transcripts for THEMIS2 Gene

Unigene Clusters for THEMIS2 Gene

Thymocyte selection associated family member 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for THEMIS2 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b · 4c · 4d ^ 5 ^ 6a · 6b ^ 7a · 7b
SP1: - - - -
SP2: - - - - - -
SP3: - - - - - - - - -
SP4: - -
SP5:
SP6: -
SP7: - - -
SP8: -
SP9:
SP10: -

Relevant External Links for THEMIS2 Gene

GeneLoc Exon Structure for
THEMIS2
ECgene alternative splicing isoforms for
THEMIS2

Expression for THEMIS2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for THEMIS2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for THEMIS2 Gene

This gene is overexpressed in Whole Blood (x25.9) and Spleen (x5.5).

Protein differential expression in normal tissues from HIPED for THEMIS2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (22.1), Monocytes (15.3), and Lavage (15.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for THEMIS2 Gene



Protein tissue co-expression partners for THEMIS2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of THEMIS2 Gene:

THEMIS2

SOURCE GeneReport for Unigene cluster for THEMIS2 Gene:

Hs.10649

mRNA Expression by UniProt/SwissProt for THEMIS2 Gene:

Q5TEJ8-THMS2_HUMAN
Tissue specificity: Expressed in different endometrial adenocarcinoma cell lines and various other cell lines apart from the prostate cell line LNCaP and the ovarian cancer cell line BG1.

Evidence on tissue expression from TISSUES for THEMIS2 Gene

  • Blood(4.3)
  • Nervous system(4.3)
genes like me logo Genes that share expression patterns with THEMIS2: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for THEMIS2 Gene

Orthologs for THEMIS2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for THEMIS2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia THEMIS2 34 35
  • 99.07 (n)
dog
(Canis familiaris)
Mammalia THEMIS2 34 35
  • 82.01 (n)
cow
(Bos Taurus)
Mammalia THEMIS2 34 35
  • 81.02 (n)
mouse
(Mus musculus)
Mammalia Themis2 34 16 35
  • 77.69 (n)
rat
(Rattus norvegicus)
Mammalia Themis2 34
  • 77 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia THEMIS2 35
  • 46 (a)
OneToOne
chicken
(Gallus gallus)
Aves C23H1ORF38 34
  • 60.03 (n)
THEMIS2 35
  • 41 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia THEMIS2 35
  • 35 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia themis2 34
  • 48.23 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC100535600 34
  • 47.37 (n)
themis2 35
  • 36 (a)
OneToOne
Species where no ortholog for THEMIS2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for THEMIS2 Gene

ENSEMBL:
Gene Tree for THEMIS2 (if available)
TreeFam:
Gene Tree for THEMIS2 (if available)

Paralogs for THEMIS2 Gene

Paralogs for THEMIS2 Gene

(1) SIMAP similar genes for THEMIS2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with THEMIS2: view

Variants for THEMIS2 Gene

Sequence variations from dbSNP and Humsavar for THEMIS2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000153809 -- 27,885,422(+) CCACA(A/G)GCCCG reference, synonymous-codon, missense
rs1000268771 -- 27,885,783(+) TTTCC(C/G)TGCAC intron-variant
rs1000750738 -- 27,877,548(+) GATCT(C/T)GATCT intron-variant
rs1000769707 -- 27,875,709(+) TATTA(-/T)TTTTT intron-variant
rs1000814719 -- 27,879,416(+) CTCTC(A/G/T)GTTCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for THEMIS2 Gene

Variant ID Type Subtype PubMed ID
esv3446306 CNV duplication 20981092
esv3585564 CNV loss 21293372
esv3585565 CNV gain 21293372
nsv160741 CNV deletion 16902084
nsv509069 CNV insertion 20534489
nsv512728 CNV insertion 21212237

Variation tolerance for THEMIS2 Gene

Residual Variation Intolerance Score: 65.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.87; 87.04% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for THEMIS2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
THEMIS2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for THEMIS2 Gene

Disorders for THEMIS2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for THEMIS2 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
endometrial adenocarcinoma
  • adenocarcinoma of endometrium
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for THEMIS2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
THEMIS2
genes like me logo Genes that share disorders with THEMIS2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for THEMIS2 Gene

Publications for THEMIS2 Gene

  1. Expression of icb-1 gene is interferon-gamma inducible in breast and ovarian cancer cell lines and affects the IFN gamma-response of SK-OV-3 ovarian cancer cells. (PMID: 16219472) Treeck O. … Ortmann O. (Cytokine 2005) 2 3 22 64
  2. A novel basement membrane-induced gene identified in the human endometrial adenocarcinoma cell line HEC1B. (PMID: 9563507) Treeck O. … Vollmer G. (FEBS Lett. 1998) 3 4 22 64
  3. Knockdown of ICB-1 gene enhanced estrogen responsiveness of ovarian and breast cancer cells. (PMID: 19942713) Konwisorz A. … Treeck O. (Endocr. Relat. Cancer 2010) 3 22 64
  4. Themis2/ICB1 is a signaling scaffold that selectively regulates macrophage Toll-like receptor signaling and cytokine production. (PMID: 20644716) Peirce M.J. … Wait R. (PLoS ONE 2010) 3 4 64
  5. Single nucleotide polymorphisms in human gene icb-1 and breast cancer susceptibility. (PMID: 19308812) Springwald A. … Treeck O. (Cancer Invest. 2009) 3 22 64

Products for THEMIS2 Gene

Sources for THEMIS2 Gene

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