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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

THEMIS2 Gene

protein-coding   GIFtS: 42
GCID: GC01P028200

Thymocyte Selection Associated Family Member 2

(Previous name: chromosome 1 open reading frame 38)
(Previous symbol: C1orf38)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Thymocyte Selection Associated Family Member 21 2     Induced By Contact To Basement Membrane 11
C1orf381 2 3     ICB-12
Induced By Contact To Basement Membrane 1 Protein2 3     Basement Membrane-Induced2
Protein ICB-12 3     Protein THEMIS22
Thymocyte-Expressed Molecule Involved In Selection Protein 22 3     ICB13
Chromosome 1 Open Reading Frame 381     

External Ids:    HGNC: 168391   Entrez Gene: 94732   Ensembl: ENSG000001307757   UniProtKB: Q5TEJ83   

Export aliases for THEMIS2 gene to outside databases


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for THEMIS2 Gene: 
THEMIS2 (thymocyte selection associated family member 2) is a protein-coding gene. Diseases associated with THEMIS2 include endometrial adenocarcinoma, and breast cancer susceptibility. An important paralog of this gene is THEMIS.

UniProtKB/Swiss-Prot: THMS2_HUMAN, Q5TEJ8
Function: May constitute a control point in macrophage inflammatory response, promoting LPS-induced TNF production




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NT_004610.19  NC_018912.2  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for THEMIS2
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for THEMIS2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat THEMIS2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p35.3   Ensembl cytogenetic band:  1p35.3   HGNC cytogenetic band: 1p35.2

THEMIS2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
THEMIS2 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P028200:  view genomic region     (about GC identifiers)

Start:
28,199,055 bp from pter      End:
28,213,196 bp from pter
Size:
14,142 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: THMS2_HUMAN, Q5TEJ8 (See protein sequence)
Recommended Name: Protein THEMIS2  
Size: 643 amino acids; 72049 Da
Subunit: When phosphorylated, interacts with LYN. Interacts with VAV1 and GRB2 (By similarity)
Sequence caution: Sequence=AAC16284.1; Type=Frameshift; Positions=416, 469, 494, 530, 532; Sequence=BAA96464.1;
Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAB33313.1; Type=Erroneous
initiation; Note=Translation N-terminally extended; Sequence=BAG64201.1; Type=Erroneous initiation;
Note=Translation N-terminally extended; Sequence=CAI21769.1; Type=Erroneous gene model prediction;
Sequence=CAI21771.1; Type=Erroneous gene model prediction; Sequence=CAI21773.1; Type=Erroneous gene model
prediction;
Secondary accessions: A2RTZ3 B4DZT9 B4DZY3 O60560 Q5TEJ1 Q5TEJ9 Q5TEK1 Q68DP4 Q9BYB6 Q9NS90
Alternative splicing: 6 isoforms:  Q5TEJ8-1   Q5TEJ8-2   Q5TEJ8-3   Q5TEJ8-4   Q5TEJ8-5   Q5TEJ8-6   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for THEMIS2: NX_Q5TEJ8

Explore proteomics data for THEMIS2 at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylation at Tyr-632 is induced by LPS (By similarity)
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q5TEJ8

  • THEMIS2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    THEMIS2 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001034566.1  NP_001099026.1  NP_004839.2  

    ENSEMBL proteins: 
     ENSP00000363035   ENSP00000363037   ENSP00000392414   ENSP00000413725   ENSP00000363031  
     ENSP00000398049   ENSP00000329862  

    Human Recombinant Protein Products for THEMIS2: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for THEMIS2
    OriGene Protein Over-expression Lysate for THEMIS2
    OriGene MassSpec for THEMIS2 
    OriGene Custom Protein Services for THEMIS2
    GenScript Custom Purified and Recombinant Proteins Services for THEMIS2
    Novus Biologicals THEMIS2 Protein
    Novus Biologicals THEMIS2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IEA--

    THEMIS2 for ontologies           About GeneDecksing



    THEMIS2 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for THEMIS2
    GenScript Custom Superior Antibodies Services for THEMIS2
    Novus Biologicals THEMIS2 Antibodies
    Abcam antibodies for THEMIS2
    Browse Antibodies at Cloud-Clone Corp. 
    ThermoFisher Antibodies for THEMIS2
    LSBio Antibodies in human, mouse, rat for THEMIS2 

    Assay Products for THEMIS2: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for THEMIS2
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for THEMIS2
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR025946 CABIT_dom

    Graphical View of Domain Structure for InterPro Entry Q5TEJ8

    ProtoNet protein and cluster: Q5TEJ8

    UniProtKB/Swiss-Prot: THMS2_HUMAN, Q5TEJ8
    Similarity: Belongs to the themis family


    THEMIS2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: THMS2_HUMAN, Q5TEJ8
    Function: May constitute a control point in macrophage inflammatory response, promoting LPS-induced TNF production
    Induction: By contact to a reconstituted basement membrane

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    THEMIS2 for ontologies           About GeneDecksing


    Phenotypes:
         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Themis2):
     cellular 

    THEMIS2 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for THEMIS2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for THEMIS2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for THEMIS2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for THEMIS2 

    miRNA
    Products:
        
    miRTarBase miRNAs that target THEMIS2:
    hsa-mir-197 (MIRT004216)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat THEMIS2
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate THEMIS2
    SwitchGear 3'UTR luciferase reporter plasmidTHEMIS2 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for THEMIS2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat THEMIS2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for THEMIS2
    Sirion Biotech Customized adenovirus for overexpression of THEMIS2

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for THEMIS2 (see all 15)
    OriGene ORF clones in mouse, rat for THEMIS2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript Custom all cDNA clones Services for THEMIS2
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for THEMIS2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat THEMIS2
    Sirion Biotech Customized lentivirus for stable overexpression of THEMIS2 
                         Customized lentivirus expression plasmids for stable overexpression of THEMIS2 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for THEMIS2
    Search LifeMap BioReagents cell lines for THEMIS2
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for THEMIS2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for THEMIS2

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    4 Interacting proteins for THEMIS2 (ENSP000003630314) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CRYZENSP000003393994STRING: ENSP00000339399
    ENSG00000227317ENSP000004031544STRING: ENSP00000403154
    NBL1ENSP000002897494STRING: ENSP00000289749
    --ENSP000003728604STRING: ENSP00000372860
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006954inflammatory response IEA--
    GO:0007155cell adhesion TAS9563507
    GO:0050852T cell receptor signaling pathway IEA--

    THEMIS2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for THEMIS2 (THMS2)

    Search CenterWatch for drugs/clinical trials and news about THEMIS2 / THMS2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for THEMIS2 gene (3 alternative transcripts): 
    NM_001039477.1  NM_001105556.1  NM_004848.2  

    Unigene Cluster for THEMIS2:

    Thymocyte selection associated family member 2
    Hs.10649  [show with all ESTs]
    Unigene Representative Sequence: NM_001105556
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000373925(uc001bpa.3 uc001boz.3) ENST00000373927 ENST00000427466
    ENST00000442118 ENST00000467258 ENST00000373921(uc001bpc.4 uc010ofn.2)
    ENST00000466068 ENST00000482828 ENST00000456990 ENST00000492877 ENST00000328928(uc010ofo.2)

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat THEMIS2
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate THEMIS2
    SwitchGear 3'UTR luciferase reporter plasmidTHEMIS2 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for THEMIS2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat THEMIS2
    Clone
    Products:
         
    OriGene clones in human, mouse for THEMIS2 (see all 15)
    OriGene ORF clones in mouse, rat for THEMIS2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript Custom all cDNA clones Services for THEMIS2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for THEMIS2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat THEMIS2
    Sirion Biotech Customized lentivirus for stable overexpression of THEMIS2 
                         Customized lentivirus expression plasmids for stable overexpression of THEMIS2 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for THEMIS2
    OriGene qSTAR qPCR primer pairs in human, mouse for THEMIS2
    Search SABiosciences RT2 qPCR Primer Assays in human, mouse, rat THEMIS2
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat THEMIS2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat THEMIS2

    Additional mRNA sequence: 

    AB035482.1 AB050854.1 AF323721.1 AK303090.1 AK303141.1 AK309633.1 BC031655.1 BC132692.1 
    BC133049.1 CR749321.1 

    10 DOTS entries:

    DT.100783005  DT.95110258  DT.95110255  DT.92066684  DT.100719017  DT.121404031  DT.416836  DT.100783006 
    DT.86847619  DT.91746611 

    24/181 AceView cDNA sequences (see all 181):

    AW193256 AA280149 CD365001 BM708753 W63743 AK094833 BP338649 BI758015 
    BI521256 BV178317 CR604917 BI823781 BM473038 AI927451 AI570737 AA731736 
    N33211 AB035482 AW518359 AL551609 AI866718 CA308421 CB528870 AA575924 

    GeneLoc Exon Structure

    5/10 Alternative Splicing Database (ASD) splice patterns (SP) for THEMIS2 (see all 10)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b · 4c · 4d ^ 5 ^ 6a · 6b ^ 7a · 7b
    SP1:                                                        -     -     -           -                     
    SP2:                                                  -     -     -     -     -     -                     
    SP3:                                -     -     -     -     -     -     -     -     -                     
    SP4:                                -     -                                                               
    SP5:                                                                                                      


    ECgene alternative splicing isoforms for THEMIS2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    THEMIS2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    THEMIS2 Expression
    About this image


    See THEMIS2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for THEMIS2

    SOURCE GeneReport for Unigene cluster: Hs.10649

    UniProtKB/Swiss-Prot: THMS2_HUMAN, Q5TEJ8
    Tissue specificity: Expressed in different endometrial adenocarcinoma cell lines and various other cell lines
    apart from the prostate cell line LNCaP and the ovarian cancer cell line BG1

        SABiosciences Custom PCR Arrays for THEMIS2
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for THEMIS2
    OriGene qSTAR qPCR primer pairs in human, mouse for THEMIS2
    Search SABiosciences RT2 qPCR Primer Assays in human, mouse, rat THEMIS2
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat THEMIS2
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat THEMIS2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for THEMIS2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for THEMIS2 gene from 4/9 species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Themis21 , 5 cDNA sequence BC0137125
    thymocyte selection associated family member 21
    78.11(n)1
    70.09(a)1
      4 (65.90 cM)5
    2307871  NM_001033308.21  NP_001028480.11 
     1327818435 
    chicken
    (Gallus gallus)
    Aves C23H1orf381 chromosome 23 open reading frame, human C1orf38 59.46(n)
    50.86(a)
      419565  XM_417712.2  XP_417712.2 
    lizard
    (Anolis carolinensis)
    Reptilia THEMIS26
    Uncharacterized protein
    37(a)
    1 ↔ 1
    GL343743.1(40787-50983)
    zebrafish
    (Danio rerio)
    Actinopterygii THEMIS26
    thymocyte selection associated family member 2
    37(a)
    1 ↔ 1
    16(5670563-5683375)


    ENSEMBL Gene Tree for THEMIS2 (if available)
    TreeFam Gene Tree for THEMIS2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for THEMIS2 gene
    THEMIS2  
    1 SIMAP similar gene for THEMIS2 using alignment to 3 protein entries:     THMS2_HUMAN (see all proteins):
    THEMIS

    THEMIS2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/445 SNPs in THEMIS2 are shown (see all 445)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs607934871,2
    C,F--28197119(+) TGGAGT/GGCAGT 3 -- us2k12Minor allele frequency- G:0.12NA EA 240
    rs1459088471,2
    --28197120(+) GGAGTA/GCAGTG 3 -- us2k10--------
    rs1384603531,2
    --28197186(+) CTCAGA/TCTCCT 3 -- us2k10--------
    rs1402406481,2
    --28197246(+) ATTTAC/TTTATT 3 -- us2k10--------
    rs1451949231,2
    C--28197300(+) CTGGAA/GTAAAG 3 -- us2k10--------
    rs1929126611,2
    C--28197317(+) GATCTC/TGGCTC 3 -- us2k10--------
    rs350737601,2
    C--28197336(+) CTCTG-/CCCCCC 3 -- us2k10--------
    rs112476971,2
    C,A,H--28197454(+) ttgttA/Gcccaa 3 -- us2k13Minor allele frequency- G:0.15NA CSA 125
    rs112476981,2
    C,A,H--28197517(+) tcaagC/Tgattc 3 -- us2k11Minor allele frequency- T:0.50CSA 2
    rs1851279281,2
    --28197633(+) GGTCTC/GGAACT 3 -- us2k10--------

    HapMap Linkage Disequilibrium report for THEMIS2 (28199055 - 28213196 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for THEMIS2: --
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing THEMIS2
    DNA2.0 Custom Variant and Variant Library Synthesis for THEMIS2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    6 diseases for THEMIS2:    About MalaCards
    endometrial adenocarcinoma    breast cancer susceptibility    ovarian cancer    breast cancer
    adenocarcinoma    prostatitis


    THEMIS2 for disorders           About GeneDecksing


    Export disorders for THEMIS2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for THEMIS2 gene, integrated from 9 sources (see all 18):
    (articles sorted by number of sources associating them with THEMIS2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Expression of icb-1 gene is interferon-gamma inducible in breast and ovarian cancer cell lines and affects the IFN gamma-response of SK-OV-3 ovarian cancer cells. (PubMed id 16219472)1, 3, 9 Treeck O....Ortmann O. (2005)
    2. A novel basement membrane-induced gene identified in the human endometrial adenocarcinoma cell line HEC1B. (PubMed id 9563507)1, 2, 9 Treeck O.... Vollmer G. (1998)
    3. Themis2/ICB1 is a signaling scaffold that selectively regulates macrophage Toll-like receptor signaling and cytokine production. (PubMed id 20644716)1, 2 Peirce M.J.... Wait R. (2010)
    4. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    7. Knockdown of ICB-1 gene enhanced estrogen responsiven ess of ovarian and breast cancer cells. (PubMed id 19942713)1, 9 Konwisorz A....Treeck O. (2010)
    8. Detection of increased icb-1 transcript levels in maturing HL-60 cells: a novel marker for granulocytic and monocytic in vitro differentiation. (PubMed id 12191572)1, 9 Treeck O....Vollmer G. (2002)
    9. Single Nucleotide Polymorphisms in Human Gene icb-1 and Breast Cancer Susceptibility. (PubMed id 19308812)1, 9 Springwald A....Treeck O. (2009)
    10. icb-1 Gene counteracts growth of ovarian cancer cell l ines. (PubMed id 23474491)1 Treeck O....Ortmann O. (2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9473 HGNC: 16839 AceView: C1orf38 Ensembl:ENSG00000130775 euGenes: HUgn9473
    ECgene: THEMIS2 H-InvDB: THEMIS2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for THEMIS2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for THEMIS2 gene:
    Search GeneIP for patents involving THEMIS2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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