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THEMIS2 Gene

protein-coding   GIFtS: 41
GCID: GC01P028200

Thymocyte Selection Associated Family Member 2

(Previous name: chromosome 1 open reading frame 38)
(Previous symbol: C1orf38)
  See THEMIS2-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Thymocyte Selection Associated Family Member 21 2     Induced By Contact To Basement Membrane 11
C1orf381 2 3     ICB-12
Induced By Contact To Basement Membrane 1 Protein2 3     Basement Membrane-Induced2
Protein ICB-12 3     Protein THEMIS22
Thymocyte-Expressed Molecule Involved In Selection Protein 22 3     ICB13
Chromosome 1 Open Reading Frame 381     

External Ids:    HGNC: 168391   Entrez Gene: 94732   Ensembl: ENSG000001307757   UniProtKB: Q5TEJ83   

Export aliases for THEMIS2 gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for THEMIS2 Gene:
THEMIS2 (thymocyte selection associated family member 2) is a protein-coding gene. Diseases associated with THEMIS2 include endometrial adenocarcinoma. An important paralog of this gene is THEMIS.

UniProtKB/Swiss-Prot: THMS2_HUMAN, Q5TEJ8
Function: May constitute a control point in macrophage inflammatory response, promoting LPS-induced TNF production




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NT_032977.10  NC_018912.2  
Regulatory elements:
   Search for regulatory transcription factor binding sites for THEMIS2
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for THEMIS2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat THEMIS2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p35.3   Ensembl cytogenetic band:  1p35.3   HGNC cytogenetic band: 1p35.2

THEMIS2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
THEMIS2 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P028200:  view genomic region     (about GC identifiers)

Start:
28,199,055 bp from pter      End:
28,213,196 bp from pter
Size:
14,142 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: THMS2_HUMAN, Q5TEJ8 (See protein sequence)
Recommended Name: Protein THEMIS2  
Size: 643 amino acids; 72049 Da
Subunit: When phosphorylated, interacts with LYN. Interacts with VAV1 and GRB2 (By similarity)
Sequence caution: Sequence=AAC16284.1; Type=Frameshift; Positions=416, 469, 494, 530, 532; Sequence=BAA96464.1;
Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAB33313.1; Type=Erroneous
initiation; Note=Translation N-terminally extended; Sequence=BAG64201.1; Type=Erroneous initiation;
Note=Translation N-terminally extended; Sequence=CAI21769.1; Type=Erroneous gene model prediction;
Sequence=CAI21771.1; Type=Erroneous gene model prediction; Sequence=CAI21773.1; Type=Erroneous gene model
prediction;
Secondary accessions: A2RTZ3 B4DZT9 B4DZY3 O60560 Q5TEJ1 Q5TEJ9 Q5TEK1 Q68DP4 Q9BYB6 Q9NS90
Alternative splicing: 6 isoforms:  Q5TEJ8-1   Q5TEJ8-2   Q5TEJ8-3   Q5TEJ8-4   Q5TEJ8-5   Q5TEJ8-6   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for THEMIS2: NX_Q5TEJ8

Explore proteomics data for THEMIS2 at MOPED

Post-translational modifications: 

  • Phosphorylation at Tyr-632 is induced by LPS (By similarity)1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See THEMIS2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (5 alternative transcripts): 
    NP_001034566.1  NP_001099026.1  NP_001273042.1  NP_001273044.1  NP_004839.2  

    ENSEMBL proteins: 
     ENSP00000363035   ENSP00000363037   ENSP00000392414   ENSP00000413725   ENSP00000363031  
     ENSP00000398049   ENSP00000329862  

    THEMIS2 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for THEMIS2
    OriGene Protein Over-expression Lysate for THEMIS2
    OriGene MassSpec for THEMIS2
    OriGene Custom Protein Services for THEMIS2
    GenScript Custom Purified and Recombinant Proteins Services for THEMIS2
    Novus Biologicals THEMIS2 Protein
    Novus Biologicals THEMIS2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for THEMIS2 

    THEMIS2 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Novus Biologicals THEMIS2 Antibodies
    Search for Antibodies for THEMIS2 at Abcam
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibodies for THEMIS2
    LSBio Antibodies in human, mouse, rat for THEMIS2

    THEMIS2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for THEMIS2
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for THEMIS2
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for THEMIS2 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR025946 CABIT_dom

    Graphical View of Domain Structure for InterPro Entry Q5TEJ8

    ProtoNet protein and cluster: Q5TEJ8

    UniProtKB/Swiss-Prot: THMS2_HUMAN, Q5TEJ8
    Similarity: Belongs to the themis family


    Find genes that share domains with THEMIS2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: THMS2_HUMAN, Q5TEJ8
    Function: May constitute a control point in macrophage inflammatory response, promoting LPS-induced TNF production
    Induction: By contact to a reconstituted basement membrane

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    Find genes that share ontologies with THEMIS2           About GenesLikeMe


    Phenotypes:
         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Themis2):
     cellular 

    Find genes that share phenotypes with THEMIS2           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for THEMIS2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for THEMIS2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for THEMIS2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for THEMIS2

    miRNA
    Products:
        
    miRTarBase miRNAs that target THEMIS2:
    hsa-mir-197-3p (MIRT004216), hsa-mir-335-5p (MIRT017480)

    Block miRNA regulation of human, mouse, rat THEMIS2 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate THEMIS2
    SwitchGear 3'UTR luciferase reporter plasmidTHEMIS2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for THEMIS2
    Predesigned siRNA for gene silencing in human, mouse, rat THEMIS2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for THEMIS2

    Clone
    Products:
         
    OriGene clones in human, mouse for THEMIS2 (see all 16)
    OriGene ORF clones in mouse, rat for THEMIS2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript Custom all cDNA clones Services for THEMIS2
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for THEMIS2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat THEMIS2

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for THEMIS2
    Browse ESI BIO Cell Lines and PureStem Progenitors for THEMIS2 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for THEMIS2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IEA--

    Find genes that share ontologies with THEMIS2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for THEMIS2
    Interactions:

        Search GeneGlobe Interaction Network for THEMIS2

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5 Interacting proteins for THEMIS2 (ENSP000003630314) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CRYZENSP000003393994STRING: ENSP00000339399
    ENSG00000227317ENSP000004031544STRING: ENSP00000403154
    NBL1ENSP000002897494STRING: ENSP00000289749
    GRB2ENSP000003390074STRING: ENSP00000339007
    --ENSP000003728604STRING: ENSP00000372860
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006954inflammatory response IEA--
    GO:0007155cell adhesion TAS9563507
    GO:0050852T cell receptor signaling pathway IEA--

    Find genes that share ontologies with THEMIS2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for THEMIS2 (THMS2)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for THEMIS2 gene (5 alternative transcripts): 
    NM_001039477.2  NM_001105556.2  NM_001286113.1  NM_001286115.1  NM_004848.3  

    Unigene Cluster for THEMIS2:

    Thymocyte selection associated family member 2
    Hs.10649  [show with all ESTs]
    Unigene Representative Sequence: NM_001105556
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000373925(uc001bpa.3 uc001boz.3) ENST00000373927 ENST00000427466
    ENST00000442118 ENST00000467258 ENST00000373921(uc001bpc.4 uc010ofn.2)
    ENST00000466068 ENST00000482828 ENST00000456990 ENST00000492877 ENST00000328928(uc010ofo.2)

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat THEMIS2 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate THEMIS2
    SwitchGear 3'UTR luciferase reporter plasmidTHEMIS2 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for THEMIS2
    Predesigned siRNA for gene silencing in human, mouse, rat THEMIS2
    Clone
    Products:
         
    OriGene clones in human, mouse for THEMIS2 (see all 16)
    OriGene ORF clones in mouse, rat for THEMIS2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript Custom all cDNA clones Services for THEMIS2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for THEMIS2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat THEMIS2
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for THEMIS2
    OriGene qSTAR qPCR primer pairs in human, mouse for THEMIS2
    Search Pre-validated RT2 qPCR Primer Assays in human, mouse, rat THEMIS2
      QuantiTect SYBR Green Assays in human, mouse, rat THEMIS2
      QuantiFast Probe-based Assays in human, mouse, rat THEMIS2

    Additional mRNA sequence: 

    AB035482.1 AB050854.1 AF323721.1 AK303090.1 AK303141.1 AK309633.1 BC031655.1 BC132692.1 
    BC133049.1 CR749321.1 

    10 DOTS entries:

    DT.100783005  DT.95110258  DT.95110255  DT.92066684  DT.100719017  DT.121404031  DT.416836  DT.100783006 
    DT.86847619  DT.91746611 

    Selected AceView cDNA sequences (see all 181):

    BI823781 AA455658 CR604917 BP338649 AA280149 CA308421 AW193256 AI927451 
    BV178317 AK094833 AW518359 CB528870 N33211 AA575924 AI570737 AA731736 
    W63743 CD365001 BI521256 AL551609 BM473038 BP339331 AB035482 AI866718 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for THEMIS2 (see all 10)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b · 4c · 4d ^ 5 ^ 6a · 6b ^ 7a · 7b
    SP1:                                                        -     -     -           -                     
    SP2:                                                  -     -     -     -     -     -                     
    SP3:                                -     -     -     -     -     -     -     -     -                     
    SP4:                                -     -                                                               
    SP5:                                                                                                      


    ECgene alternative splicing isoforms for THEMIS2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    THEMIS2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    THEMIS2 Expression
    About this image


    THEMIS2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Testis (Reproductive System)
     
     Spleen (Hematopoietic System)
    THEMIS2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    THEMIS2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.10649

    UniProtKB/Swiss-Prot: THMS2_HUMAN, Q5TEJ8
    Tissue specificity: Expressed in different endometrial adenocarcinoma cell lines and various other cell lines
    apart from the prostate cell line LNCaP and the ovarian cancer cell line BG1

        Custom PCR Arrays for THEMIS2
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    QuantiFast Probe-based Assays in human, mouse, rat THEMIS2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for THEMIS2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for THEMIS2 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Themis21 , 5 cDNA sequence BC0137125
    thymocyte selection associated family member 21
    77.69(n)1
    69.62(a)1
      4 (65.90 cM)5
    2307871  NM_001033308.21  NP_001028480.11 
     1327818435 
    chicken
    (Gallus gallus)
    Aves C23H1ORF381 chromosome 23 open reading frame, human C1orf38 60.03(n)
    51.34(a)
      419565  XM_417712.3  XP_417712.2 
    lizard
    (Anolis carolinensis)
    Reptilia THEMIS26
    thymocyte selection associated family member 2
    35(a)
    1 ↔ 1
    GL343743.1(40787-50983)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia themis21 thymocyte selection associated family member 2 48.23(n)
    38.55(a)
      101732414  XM_004912318.1  XP_004912375.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1005356001 protein THEMIS2-like 47.37(n)
    38.87(a)
      100535600  XM_005157857.1  XP_005157914.1 


    ENSEMBL Gene Tree for THEMIS2 (if available)
    TreeFam Gene Tree for THEMIS2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for THEMIS2 gene
    THEMIS2  
    1 SIMAP similar gene for THEMIS2 using alignment to 3 protein entries:     THMS2_HUMAN (see all proteins):
    THEMIS

    Find genes that share paralogs with THEMIS2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for THEMIS2 (see all 445)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs607934871,2
    C,F--28197119(+) TGGAGT/GGCAGT 3 -- us2k12Minor allele frequency- G:0.12NA EA 240
    rs1459088471,2
    --28197120(+) GGAGTA/GCAGTG 3 -- us2k10--------
    rs1384603531,2
    --28197186(+) CTCAGA/TCTCCT 3 -- us2k10--------
    rs1402406481,2
    --28197246(+) ATTTAC/TTTATT 3 -- us2k10--------
    rs1451949231,2
    C--28197300(+) CTGGAA/GTAAAG 3 -- us2k10--------
    rs1929126611,2
    C--28197317(+) GATCTC/TGGCTC 3 -- us2k10--------
    rs350737601,2
    C--28197336(+) CTCTG-/CCCCCC 3 -- us2k10--------
    rs112476971,2
    C,A,H--28197454(+) ttgttA/Gcccaa 3 -- us2k13Minor allele frequency- G:0.15NA CSA 125
    rs112476981,2
    C,A,H--28197517(+) tcaagC/Tgattc 3 -- us2k11Minor allele frequency- T:0.50CSA 2
    rs1851279281,2
    --28197633(+) GGTCTC/GGAACT 3 -- us2k10--------

    HapMap Linkage Disequilibrium report for THEMIS2 (28199055 - 28213196 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for THEMIS2: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing THEMIS2
    DNA2.0 Custom Variant and Variant Library Synthesis for THEMIS2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    1 disease for THEMIS2:    
    About MalaCards
    endometrial adenocarcinoma


    Find genes that share disorders with THEMIS2           About GenesLikeMe


    Export disorders for THEMIS2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for THEMIS2 gene, integrated from 10 sources (see all 18):
    (articles sorted by number of sources associating them with THEMIS2)
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    1. Expression of icb-1 gene is interferon-gamma inducible in breast and ovarian cancer cell lines and affects the IFN gamma-response of SK-OV-3 ovarian cancer cells. (PubMed id 16219472)1, 3, 9 Treeck O....Ortmann O. (Cytokine 2005)
    2. A novel basement membrane-induced gene identified in the human endometrial adenocarcinoma cell line HEC1B. (PubMed id 9563507)1, 2, 9 Treeck O.... Vollmer G. (FEBS Lett. 1998)
    3. Themis2/ICB1 is a signaling scaffold that selectively regulates macrophage Toll-like receptor signaling and cytokine production. (PubMed id 20644716)1, 2 Peirce M.J.... Wait R. (PLoS ONE 2010)
    4. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    7. Knockdown of ICB-1 gene enhanced estrogen responsiveness of ovarian and breast cancer cells. (PubMed id 19942713)1, 9 Konwisorz A....Treeck O. (Endocr. Relat. Cancer 2010)
    8. Detection of increased icb-1 transcript levels in maturing HL-60 cells: a novel marker for granulocytic and monocytic in vitro differentiation. (PubMed id 12191572)1, 9 Treeck O....Vollmer G. (Leuk. Res. 2002)
    9. Single nucleotide polymorphisms in human gene icb-1 and breast cancer susceptibility. (PubMed id 19308812)1, 9 Springwald A....Treeck O. (Cancer Invest. 2009)
    10. icb-1 Gene counteracts growth of ovarian cancer cell lines. (PubMed id 23474491)1 Treeck O....Ortmann O. (Cancer Lett. 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9473 HGNC: 16839 AceView: C1orf38 Ensembl:ENSG00000130775 euGenes: HUgn9473
    ECgene: THEMIS2 H-InvDB: THEMIS2

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for THEMIS2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for THEMIS2 gene:
    Search GeneIP for patents involving THEMIS2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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