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Aliases for THEMIS2 Gene

Aliases for THEMIS2 Gene

  • Thymocyte Selection Associated Family Member 2 2 3 5
  • Thymocyte-Expressed Molecule Involved In Selection Protein 2 3 4
  • Induced By Contact To Basement Membrane 1 Protein 3 4
  • Protein ICB-1 3 4
  • C1orf38 3 4
  • Induced By Contact To Basement Membrane 1 2
  • Chromosome 1 Open Reading Frame 38 2
  • Basement Membrane-Induced 3
  • ICB-1 3
  • ICB1 4

External Ids for THEMIS2 Gene

Previous HGNC Symbols for THEMIS2 Gene

  • C1orf38

Previous GeneCards Identifiers for THEMIS2 Gene

  • GC01P028200

Summaries for THEMIS2 Gene

GeneCards Summary for THEMIS2 Gene

THEMIS2 (Thymocyte Selection Associated Family Member 2) is a Protein Coding gene. Diseases associated with THEMIS2 include Endometrial Adenocarcinoma. An important paralog of this gene is THEMIS.

UniProtKB/Swiss-Prot for THEMIS2 Gene

  • May constitute a control point in macrophage inflammatory response, promoting LPS-induced TNF production.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for THEMIS2 Gene

Genomics for THEMIS2 Gene

Regulatory Elements for THEMIS2 Gene

Enhancers for THEMIS2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around THEMIS2 on UCSC Golden Path with GeneCards custom track

Promoters for THEMIS2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around THEMIS2 on UCSC Golden Path with GeneCards custom track

Genomic Location for THEMIS2 Gene

Chromosome:
1
Start:
27,872,543 bp from pter
End:
27,886,685 bp from pter
Size:
14,143 bases
Orientation:
Plus strand

Genomic View for THEMIS2 Gene

Genes around THEMIS2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
THEMIS2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for THEMIS2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for THEMIS2 Gene

Proteins for THEMIS2 Gene

  • Protein details for THEMIS2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5TEJ8-THMS2_HUMAN
    Recommended name:
    Protein THEMIS2
    Protein Accession:
    Q5TEJ8
    Secondary Accessions:
    • A2RTZ3
    • B4DZT9
    • B4DZY3
    • O60560
    • Q5TEJ1
    • Q5TEJ9
    • Q5TEK1
    • Q68DP4
    • Q9BYB6
    • Q9NS90

    Protein attributes for THEMIS2 Gene

    Size:
    643 amino acids
    Molecular mass:
    72049 Da
    Quaternary structure:
    • When phosphorylated, interacts with LYN. Interacts with VAV1 and GRB2 (By similarity).
    SequenceCaution:
    • Sequence=AAC16284.1; Type=Frameshift; Positions=416, 469, 494, 530, 532; Evidence={ECO:0000305}; Sequence=BAA96464.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB33313.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAG64201.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAI21769.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI21771.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI21773.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for THEMIS2 Gene

neXtProt entry for THEMIS2 Gene

Proteomics data for THEMIS2 Gene at MOPED

Post-translational modifications for THEMIS2 Gene

No data available for DME Specific Peptides for THEMIS2 Gene

Domains & Families for THEMIS2 Gene

Protein Domains for THEMIS2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for THEMIS2 Gene

Graphical View of Domain Structure for InterPro Entry

Q5TEJ8

UniProtKB/Swiss-Prot:

THMS2_HUMAN :
  • Belongs to the themis family.
Family:
  • Belongs to the themis family.
genes like me logo Genes that share domains with THEMIS2: view

No data available for Gene Families for THEMIS2 Gene

Function for THEMIS2 Gene

Molecular function for THEMIS2 Gene

UniProtKB/Swiss-Prot Function:
May constitute a control point in macrophage inflammatory response, promoting LPS-induced TNF production.
UniProtKB/Swiss-Prot Induction:
By contact to a reconstituted basement membrane.

Phenotypes for THEMIS2 Gene

genes like me logo Genes that share phenotypes with THEMIS2: view

Animal Models for THEMIS2 Gene

MGI Knock Outs for THEMIS2:

Animal Model Products

CRISPR Products

miRNA for THEMIS2 Gene

miRTarBase miRNAs that target THEMIS2

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for THEMIS2 Gene

Localization for THEMIS2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for THEMIS2 Gene COMPARTMENTS Subcellular localization image for THEMIS2 gene
Compartment Confidence
nucleus 3
cytosol 2
golgi apparatus 2
mitochondrion 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for THEMIS2 Gene

Pathways & Interactions for THEMIS2 Gene

SuperPathways for THEMIS2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for THEMIS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion TAS 9563507
genes like me logo Genes that share ontologies with THEMIS2: view

No data available for Pathways by source and SIGNOR curated interactions for THEMIS2 Gene

Drugs & Compounds for THEMIS2 Gene

No Compound Related Data Available

Transcripts for THEMIS2 Gene

Unigene Clusters for THEMIS2 Gene

Thymocyte selection associated family member 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for THEMIS2 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b · 4c · 4d ^ 5 ^ 6a · 6b ^ 7a · 7b
SP1: - - - -
SP2: - - - - - -
SP3: - - - - - - - - -
SP4: - -
SP5:
SP6: -
SP7: - - -
SP8: -
SP9:
SP10: -

Relevant External Links for THEMIS2 Gene

GeneLoc Exon Structure for
THEMIS2
ECgene alternative splicing isoforms for
THEMIS2

Expression for THEMIS2 Gene

mRNA expression in normal human tissues for THEMIS2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for THEMIS2 Gene

This gene is overexpressed in Whole Blood (x25.9) and Spleen (x5.5).

Protein differential expression in normal tissues from HIPED for THEMIS2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (22.1), Monocytes (15.3), and Lavage (15.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for THEMIS2 Gene



SOURCE GeneReport for Unigene cluster for THEMIS2 Gene Hs.10649

mRNA Expression by UniProt/SwissProt for THEMIS2 Gene

Q5TEJ8-THMS2_HUMAN
Tissue specificity: Expressed in different endometrial adenocarcinoma cell lines and various other cell lines apart from the prostate cell line LNCaP and the ovarian cancer cell line BG1.
genes like me logo Genes that share expression patterns with THEMIS2: view

Protein tissue co-expression partners for THEMIS2 Gene

- Elite partner

Primer Products

Orthologs for THEMIS2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for THEMIS2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia THEMIS2 35
  • 81.02 (n)
  • 71.61 (a)
THEMIS2 36
  • 68 (a)
OneToOne
dog
(Canis familiaris)
Mammalia THEMIS2 35
  • 82.01 (n)
  • 74.26 (a)
THEMIS2 36
  • 73 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Themis2 35
  • 77.69 (n)
  • 69.62 (a)
Themis2 16
Themis2 36
  • 66 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia THEMIS2 35
  • 99.07 (n)
  • 98.44 (a)
THEMIS2 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Themis2 35
  • 77 (n)
  • 70.59 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia THEMIS2 36
  • 46 (a)
OneToOne
chicken
(Gallus gallus)
Aves C23H1ORF38 35
  • 60.03 (n)
  • 51.34 (a)
THEMIS2 36
  • 41 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia THEMIS2 36
  • 35 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia themis2 35
  • 48.23 (n)
  • 38.55 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC100535600 35
  • 47.37 (n)
  • 38.87 (a)
themis2 36
  • 36 (a)
OneToOne
Species with no ortholog for THEMIS2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for THEMIS2 Gene

ENSEMBL:
Gene Tree for THEMIS2 (if available)
TreeFam:
Gene Tree for THEMIS2 (if available)

Paralogs for THEMIS2 Gene

Paralogs for THEMIS2 Gene

(1) SIMAP similar genes for THEMIS2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with THEMIS2: view

Variants for THEMIS2 Gene

Sequence variations from dbSNP and Humsavar for THEMIS2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs35995543 - 27,882,615(-) CTCCA(C/G)GAAAC intron-variant, reference, missense
rs3766400 - 27,882,855(+) TTGTG(A/G)AGGCC intron-variant, reference, missense
rs6564 -- 27,886,464(-) GCCAA(A/G)TTCCC utr-variant-3-prime
rs6565 -- 27,886,646(-) ATTCT(A/G)TGGTT utr-variant-3-prime
rs11399 -- 27,886,295(+) TCACA(C/T)TGCAT utr-variant-3-prime

Variation tolerance for THEMIS2 Gene

Residual Variation Intolerance Score: 65.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.87; 87.04% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for THEMIS2 Gene

Disorders for THEMIS2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for THEMIS2 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
endometrial adenocarcinoma
  • adenocarcinoma of endometrium
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for THEMIS2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
THEMIS2
genes like me logo Genes that share disorders with THEMIS2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for THEMIS2 Gene

Publications for THEMIS2 Gene

  1. Expression of icb-1 gene is interferon-gamma inducible in breast and ovarian cancer cell lines and affects the IFN gamma-response of SK-OV-3 ovarian cancer cells. (PMID: 16219472) Treeck O. … Ortmann O. (Cytokine 2005) 2 3 23 67
  2. Knockdown of ICB-1 gene enhanced estrogen responsiveness of ovarian and breast cancer cells. (PMID: 19942713) Konwisorz A. … Treeck O. (Endocr. Relat. Cancer 2010) 3 23
  3. Single nucleotide polymorphisms in human gene icb-1 and breast cancer susceptibility. (PMID: 19308812) Springwald A. … Treeck O. (Cancer Invest. 2009) 3 23
  4. Detection of increased icb-1 transcript levels in maturing HL-60 cells: a novel marker for granulocytic and monocytic in vitro differentiation. (PMID: 12191572) Treeck O. … Vollmer G. (Leuk. Res. 2002) 3 23
  5. A novel basement membrane-induced gene identified in the human endometrial adenocarcinoma cell line HEC1B. (PMID: 9563507) Treeck O. … Vollmer G. (FEBS Lett. 1998) 3 23

Products for THEMIS2 Gene

Sources for THEMIS2 Gene

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