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Aliases for THEMIS Gene

Aliases for THEMIS Gene

  • Thymocyte Selection Associated 2 3 5
  • Thymocyte-Expressed Molecule Involved In Selection 3 4
  • Thymocyte Selection Pathway Associated 2 3
  • C6orf190 3 4
  • C6orf207 3 4
  • Thymocyte Expressed Molecule Involved In Selection 2
  • Signaling Phosphoprotein Specific For T Cells 3
  • Chromosome 6 Open Reading Frame 207 2
  • Chromosome 6 Open Reading Frame 190 2
  • GRB2-Associated Protein 3
  • Protein THEMIS 3
  • TSEPA 3
  • GASP 3
  • SPOT 3

External Ids for THEMIS Gene

Previous HGNC Symbols for THEMIS Gene

  • C6orf207
  • C6orf190
  • TSEPA

Previous GeneCards Identifiers for THEMIS Gene

  • GC06M128029
  • GC06M125605

Summaries for THEMIS Gene

Entrez Gene Summary for THEMIS Gene

  • This gene encodes a protein that plays a regulatory role in both positive and negative T-cell selection during late thymocyte development. The protein functions through T-cell antigen receptor signaling, and is necessary for proper lineage commitment and maturation of T-cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2009]

GeneCards Summary for THEMIS Gene

THEMIS (Thymocyte Selection Associated) is a Protein Coding gene. Among its related pathways are NF-kappaB Signaling. An important paralog of this gene is THEMIS2.

UniProtKB/Swiss-Prot for THEMIS Gene

  • Plays a central role in late thymocyte development by controlling both positive and negative T-cell selection. Required to sustain and/or integrate signals required for proper lineage commitment and maturation of T-cells. Regulates T-cell development through T-cell antigen receptor (TCR) signaling and in particular through the regulation of calcium influx and phosphorylation of Erk.

Gene Wiki entry for THEMIS Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for THEMIS Gene

Genomics for THEMIS Gene

Regulatory Elements for THEMIS Gene

Enhancers for THEMIS Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06F127933 1.2 FANTOM5 ENCODE 7.5 -16.1 -16141 1.8 THEMIS LOC101928140 GC06P127982
GH06F127857 0.7 ENCODE 5.8 +61.0 60977 1.3 HLF THEMIS GC06M127888 ENSG00000281248
GH06F127855 0.5 ENCODE 5.8 +62.9 62861 0.2 CTCF ZNF654 SMC3 RAD21 THEMIS GC06M127888 ENSG00000281248
GH06F127737 1.2 FANTOM5 ENCODE 4.2 +181.4 181441 0.2 CTCF ZNF654 SMC3 ZNF384 RAD21 MIXL1 THEMIS ENSG00000281248 GC06M127888
GH06F127759 0.8 FANTOM5 1.9 +159.3 159294 0.4 THEMIS ENSG00000281248 GC06M127888
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around THEMIS on UCSC Golden Path with GeneCards custom track

Promoters for THEMIS Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001884857 231 400

Genomic Location for THEMIS Gene

Chromosome:
6
Start:
127,708,072 bp from pter
End:
127,918,631 bp from pter
Size:
210,560 bases
Orientation:
Minus strand

Genomic View for THEMIS Gene

Genes around THEMIS on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
THEMIS Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for THEMIS Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for THEMIS Gene

Proteins for THEMIS Gene

  • Protein details for THEMIS Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N1K5-THMS1_HUMAN
    Recommended name:
    Protein THEMIS
    Protein Accession:
    Q8N1K5
    Secondary Accessions:
    • A1L4F0
    • A8K7N1
    • B3KT31
    • B3KW32
    • B3KY07
    • F5H1J9
    • Q5T3C4
    • Q5T3C5
    • Q6MZT7

    Protein attributes for THEMIS Gene

    Size:
    641 amino acids
    Molecular mass:
    73452 Da
    Quaternary structure:
    • Interacts with PLCG1, ITK, GRB2, and LAT.
    SequenceCaution:
    • Sequence=BAC05194.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=BAG52943.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAI13397.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI17111.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for THEMIS Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for THEMIS Gene

Post-translational modifications for THEMIS Gene

  • Phosphorylated on Tyr residues quickly after TCR stimulation.
  • Ubiquitination at Lys 92, Lys 124, Lys 208, Lys 226, Lys 451, and Lys 595
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for THEMIS (THEMIS)
  • Abcam antibodies for THEMIS
  • Santa Cruz Biotechnology (SCBT) Antibodies for THEMIS

No data available for DME Specific Peptides for THEMIS Gene

Domains & Families for THEMIS Gene

Protein Domains for THEMIS Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for THEMIS Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N1K5

UniProtKB/Swiss-Prot:

THMS1_HUMAN :
  • Belongs to the themis family.
Family:
  • Belongs to the themis family.
genes like me logo Genes that share domains with THEMIS: view

No data available for Gene Families for THEMIS Gene

Function for THEMIS Gene

Molecular function for THEMIS Gene

UniProtKB/Swiss-Prot Function:
Plays a central role in late thymocyte development by controlling both positive and negative T-cell selection. Required to sustain and/or integrate signals required for proper lineage commitment and maturation of T-cells. Regulates T-cell development through T-cell antigen receptor (TCR) signaling and in particular through the regulation of calcium influx and phosphorylation of Erk.

Gene Ontology (GO) - Molecular Function for THEMIS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 23455924
genes like me logo Genes that share ontologies with THEMIS: view
genes like me logo Genes that share phenotypes with THEMIS: view

Animal Models for THEMIS Gene

MGI Knock Outs for THEMIS:

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for THEMIS Gene

Localization for THEMIS Gene

Subcellular locations from UniProtKB/Swiss-Prot for THEMIS Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for THEMIS Gene COMPARTMENTS Subcellular localization image for THEMIS gene
Compartment Confidence
nucleus 5
cytosol 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for THEMIS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
GO:0005737 cytoplasm ISS --
GO:0005911 cell-cell junction IEA --
GO:0008180 COP9 signalosome ISS --
genes like me logo Genes that share ontologies with THEMIS: view

Pathways & Interactions for THEMIS Gene

SuperPathways for THEMIS Gene

SuperPathway Contained pathways
1 NF-kappaB Signaling
genes like me logo Genes that share pathways with THEMIS: view

Pathways by source for THEMIS Gene

1 Cell Signaling Technology pathway for THEMIS Gene

Gene Ontology (GO) - Biological Process for THEMIS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002250 adaptive immune response IEA --
GO:0002376 immune system process IEA --
GO:0007275 multicellular organism development IEA --
GO:0043368 positive T cell selection ISS --
GO:0043383 negative T cell selection ISS --
genes like me logo Genes that share ontologies with THEMIS: view

No data available for SIGNOR curated interactions for THEMIS Gene

Transcripts for THEMIS Gene

Unigene Clusters for THEMIS Gene

Thymocyte selection associated:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for THEMIS Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8
SP1:
SP2: - -
SP3: - -
SP4: - - -

Relevant External Links for THEMIS Gene

GeneLoc Exon Structure for
THEMIS
ECgene alternative splicing isoforms for
THEMIS

Expression for THEMIS Gene

mRNA expression in normal human tissues for THEMIS Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for THEMIS Gene

This gene is overexpressed in Whole Blood (x9.9), Brain - Frontal Cortex (BA9) (x6.5), Brain - Anterior cingulate cortex (BA24) (x5.9), and Brain - Cortex (x4.5).

Protein differential expression in normal tissues from HIPED for THEMIS Gene

This gene is overexpressed in Peripheral blood mononuclear cells (29.3) and CD8 Tcells (24.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for THEMIS Gene



Protein tissue co-expression partners for THEMIS Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of THEMIS Gene:

THEMIS

SOURCE GeneReport for Unigene cluster for THEMIS Gene:

Hs.661756
genes like me logo Genes that share expression patterns with THEMIS: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for THEMIS Gene

Orthologs for THEMIS Gene

This gene was present in the common ancestor of chordates.

Orthologs for THEMIS Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia THEMIS 34 35
  • 99.56 (n)
dog
(Canis familiaris)
Mammalia THEMIS 34 35
  • 88.35 (n)
cow
(Bos Taurus)
Mammalia THEMIS 34 35
  • 85.8 (n)
rat
(Rattus norvegicus)
Mammalia Themis 34
  • 83.36 (n)
mouse
(Mus musculus)
Mammalia Themis 34 16 35
  • 82.93 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia THEMIS 35
  • 70 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia THEMIS 35
  • 66 (a)
OneToOne
chicken
(Gallus gallus)
Aves THEMIS 34 35
  • 69.32 (n)
lizard
(Anolis carolinensis)
Reptilia THEMIS 35
  • 48 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia themis 34
  • 61.01 (n)
zebrafish
(Danio rerio)
Actinopterygii themis 34 35
  • 52.53 (n)
Species where no ortholog for THEMIS was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for THEMIS Gene

ENSEMBL:
Gene Tree for THEMIS (if available)
TreeFam:
Gene Tree for THEMIS (if available)

Paralogs for THEMIS Gene

Paralogs for THEMIS Gene

(5) SIMAP similar genes for THEMIS Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for THEMIS Gene

genes like me logo Genes that share paralogs with THEMIS: view

Variants for THEMIS Gene

Sequence variations from dbSNP and Humsavar for THEMIS Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1000066 -- 127,918,267(-) GCAGG(G/T)TCAAG intron-variant
rs10456972 -- 127,917,795(+) TTAAA(A/G)ATAAA intron-variant
rs10457503 -- 127,730,576(+) ttaat(A/G)ttttt intron-variant
rs10484715 -- 127,720,588(+) CTCAG(C/T)GTAAA intron-variant
rs10484716 -- 127,854,577(+) GATAA(A/G)AAAGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for THEMIS Gene

Variant ID Type Subtype PubMed ID
dgv1218e214 CNV loss 21293372
esv1281893 CNV insertion 17803354
esv1510942 CNV insertion 17803354
esv2484840 CNV deletion 19546169
esv2664026 CNV deletion 23128226
esv3610728 CNV gain 21293372
esv3610731 CNV loss 21293372
esv6210 CNV gain 19470904
nsv1024516 CNV loss 25217958
nsv1148104 CNV insertion 26484159
nsv518548 CNV loss 19592680
nsv525919 CNV loss 19592680
nsv819539 CNV gain 19587683
nsv830799 CNV loss 17160897

Variation tolerance for THEMIS Gene

Residual Variation Intolerance Score: 83.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.40; 42.40% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for THEMIS Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
THEMIS

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for THEMIS Gene

Disorders for THEMIS Gene

Relevant External Links for THEMIS

Genetic Association Database (GAD)
THEMIS
Human Genome Epidemiology (HuGE) Navigator
THEMIS
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
THEMIS

No disorders were found for THEMIS Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for THEMIS Gene

Publications for THEMIS Gene

  1. Novel breast cancer risk alleles and interaction with ionizing radiation among U.S. radiologic technologists. (PMID: 20095854) Bhatti P. … Sigurdson A.J. (Radiat. Res. 2010) 3 46 64
  2. Multiple common variants for celiac disease influencing immune gene expression. (PMID: 20190752) Dubois P.C. … van Heel D.A. (Nat. Genet. 2010) 3 46 64
  3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 64
  4. Themis is a member of a new metazoan gene family and is required for the completion of thymocyte positive selection. (PMID: 19597497) Johnson A.L. … Schwartz R.H. (Nat. Immunol. 2009) 2 3 64
  5. Themis, a T cell-specific protein important for late thymocyte development. (PMID: 19597498) Lesourne R. … Love P.E. (Nat. Immunol. 2009) 2 3 64

Products for THEMIS Gene

Sources for THEMIS Gene

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