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THEMIS Gene

protein-coding   GIFtS: 51
GCID: GC06M128029

Thymocyte Selection Associated

(Previous names: chromosome 6 open reading frame 207, chromosome 6 open reading...)
(Previous symbols: C6orf207, C6orf190, TSEPA)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Thymocyte Selection Associated1 2     Chromosome 6 Open Reading Frame 1901
C6orf1901 2 3     Chromosome 6 Open Reading Frame 2071
C6orf2071 2 3     bA325O24.32
TSEPA1 2     bA325O24.42
Thymocyte Selection Pathway Associated1 2     GRB2-Associated Protein2
Thymocyte Expressed Molecule Involved In Selection1 2     Protein THEMIS2
Thymocyte-Expressed Molecule Involved In Selection2 3     Signaling Phosphoprotein Specific For T Cells2
GASP2 5     C6ORF1905
SPOT2 5     

External Ids:    HGNC: 215691   Entrez Gene: 3873572   Ensembl: ENSG000001726737   OMIM: 6136075   UniProtKB: Q8N1K53   

Export aliases for THEMIS gene to outside databases

Previous GC identifer: GC06M125605


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for THEMIS Gene:
This gene encodes a protein that plays a regulatory role in both positive and negative T-cell selection during
late thymocyte development. The protein functions through T-cell antigen receptor signaling, and is necessary for
proper lineage commitment and maturation of T-cells. Alternative splicing results in multiple transcript
variants. (provided by RefSeq, Sep 2009)

GeneCards Summary for THEMIS Gene:
THEMIS (thymocyte selection associated) is a protein-coding gene. An important paralog of this gene is THEMIS2.

UniProtKB/Swiss-Prot: THMS1_HUMAN, Q8N1K5
Function: Plays a central role in late thymocyte development by controlling both positive and negative T-cell
selection. Required to sustain and/or integrate signals required for proper lineage commitment and maturation of
T-cells. Regulates T-cell development through T-cell antigen receptor (TCR) signaling and in particular through
the regulation of calcium influx and phosphorylation of Erk (By similarity)

Gene Wiki entry for THEMIS (Protein THEMIS) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000006.11  NT_025741.16  NT_187556.1  NC_018917.2  
Regulatory elements:
   Search for regulatory transcription factor binding sites for THEMIS
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for THEMIS

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat THEMIS


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q22.33   Ensembl cytogenetic band:  6q22.33   HGNC cytogenetic band: 6q22.33

THEMIS Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
THEMIS gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M128029:  view genomic region     (about GC identifiers)

Start:
128,029,217 bp from pter      End:
128,239,776 bp from pter
Size:
210,560 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: THMS1_HUMAN, Q8N1K5 (See protein sequence)
Recommended Name: Protein THEMIS  
Size: 641 amino acids; 73452 Da
Subunit: Interacts with PLCG1, ITK, GRB2, and LAT (By similarity)
Sequence caution: Sequence=BAC05194.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential
poly-A sequence; Sequence=BAG52943.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=CAI13397.1; Type=Erroneous gene model prediction; Sequence=CAI17111.1; Type=Erroneous gene model
prediction;
Secondary accessions: A1L4F0 A8K7N1 B3KT31 B3KW32 B3KY07 Q5T3C4 Q5T3C5 Q6MZT7
Alternative splicing: 3 isoforms:  Q8N1K5-1   Q8N1K5-2   Q8N1K5-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for THEMIS: NX_Q8N1K5

Explore proteomics data for THEMIS at MOPED

Post-translational modifications: 

  • Phosphorylated on Tyr residues quickly after TCR stimulation (By similarity)1
  • Ubiquitination2 at Lys92, Lys124, Lys208, Lys226, Lys451, Lys595
  • Modification sites at PhosphoSitePlus

  • See THEMIS Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001010923.1  NP_001158157.1  NP_001158159.1  

    ENSEMBL proteins: 
     ENSP00000357233   ENSP00000387740   ENSP00000439594   ENSP00000357231   ENSP00000439863  

    THEMIS Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for THEMIS
    OriGene Custom MassSpec
    OriGene Custom Protein Services for THEMIS
    GenScript Custom Purified and Recombinant Proteins Services for THEMIS
    Novus Biologicals THEMIS Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for THEMIS

     
    Search eBioscience for Proteins for THEMIS 

    THEMIS Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for THEMIS
    Cell Signaling Technology (CST) Antibodies for THEMIS 
    OriGene Antibodies for THEMIS
    OriGene Custom Antibody Services for THEMIS
    Novus Biologicals THEMIS Antibodies
    Abcam antibodies for THEMIS
    Cloud-Clone Corp. Antibodies for THEMIS
    Search ThermoFisher Antibodies for THEMIS
    LSBio Antibodies in human, mouse, rat for THEMIS

    THEMIS Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for THEMIS
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for THEMIS
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for THEMIS
    Cloud-Clone Corp. CLIAs for THEMIS
    Search eBioscience for ELISAs for THEMIS 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR025946 CABIT_dom

    Graphical View of Domain Structure for InterPro Entry Q8N1K5

    ProtoNet protein and cluster: Q8N1K5

    UniProtKB/Swiss-Prot: THMS1_HUMAN, Q8N1K5
    Similarity: Belongs to the themis family


    Find genes that share domains with THEMIS           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: THMS1_HUMAN, Q8N1K5
    Function: Plays a central role in late thymocyte development by controlling both positive and negative T-cell
    selection. Required to sustain and/or integrate signals required for proper lineage commitment and maturation of
    T-cells. Regulates T-cell development through T-cell antigen receptor (TCR) signaling and in particular through
    the regulation of calcium influx and phosphorylation of Erk (By similarity)

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--
         
    Find genes that share ontologies with THEMIS           About GenesLikeMe


    Phenotypes:
         2 MGI mutant phenotypes (inferred from 6 alleles(MGI details for Themis):
     hematopoietic system  immune system 

    Find genes that share phenotypes with THEMIS           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for THEMIS: Themistm1Gasc Themistm1Lov

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for THEMIS
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for THEMIS

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for THEMIS
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for THEMIS

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat THEMIS using miScript Target Protectors
    5 qRT-PCR Assays for microRNAs that regulate THEMIS:
    hsa-miR-576-5p hsa-miR-3688-3p hsa-miR-2110 hsa-miR-944 hsa-miR-1305
    SwitchGear 3'UTR luciferase reporter plasmidTHEMIS 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for THEMIS
    Predesigned siRNA for gene silencing in human, mouse, rat THEMIS

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for THEMIS

    Clone
    Products:
         
    OriGene clones in human, mouse for THEMIS (see all 16)
    OriGene ORF clones in mouse, rat for THEMIS
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): THEMIS (NM_001010923)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for THEMIS
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat THEMIS

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for THEMIS
    Browse ESI BIO Cell Lines and PureStem Progenitors for THEMIS 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for THEMIS


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    THMS1_HUMAN, Q8N1K5: Cytoplasm (By similarity). Nucleus (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4
    cytosol2
    peroxisome1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ISS--
    GO:0005737cytoplasm ISS--
    GO:0008180COP9 signalosome ISS--

    Find genes that share ontologies with THEMIS           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for THEMIS About    
    See pathways by source

    SuperPathContained pathways About
    1Lymphocyte Signaling
    Lymphocyte Signaling


    Find genes that share SuperPaths with THEMIS           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for THEMIS
        Lymphocyte Signaling


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for THEMIS
    Interactions:

        Search GeneGlobe Interaction Network for THEMIS

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    2 Interacting proteins for THEMIS (Q8N1K51 ENSP000003572314) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PRMT6Q96LA81EBI-2873538,EBI-912440
    GRB2ENSP000003390074STRING: ENSP00000339007
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0043368positive T cell selection ISS--
    GO:0043383negative T cell selection ISS--
    GO:0050852T cell receptor signaling pathway ISS--

    Find genes that share ontologies with THEMIS           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for THEMIS (THMS1)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for THEMIS gene (3 alternative transcripts): 
    NM_001010923.2  NM_001164685.1  NM_001164687.1  

    Unigene Cluster for THEMIS:

    Thymocyte selection associated
    Hs.661756  [show with all ESTs]
    Unigene Representative Sequence: NM_001164685
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000368250 ENST00000434358 ENST00000543064(uc011ebt.2) ENST00000368248(uc021zfa.1)
    ENST00000537166(uc010kfa.3 uc010kfb.3)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat THEMIS using miScript Target Protectors
    5 qRT-PCR Assays for microRNAs that regulate THEMIS:
    hsa-miR-576-5p hsa-miR-3688-3p hsa-miR-2110 hsa-miR-944 hsa-miR-1305
    SwitchGear 3'UTR luciferase reporter plasmidTHEMIS 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for THEMIS
    Predesigned siRNA for gene silencing in human, mouse, rat THEMIS
    Clone
    Products:
         
    OriGene clones in human, mouse for THEMIS (see all 16)
    OriGene ORF clones in mouse, rat for THEMIS
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): THEMIS (NM_001010923)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for THEMIS
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat THEMIS
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for THEMIS
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat THEMIS
      QuantiTect SYBR Green Assays in human, mouse, rat THEMIS
      QuantiFast Probe-based Assays in human, mouse, rat THEMIS

    Additional mRNA sequence: 

    AK094863.1 AK097903.1 AK124031.1 AK128377.1 AK292046.1 BC043608.1 BC130516.1 BC144034.1 
    BX640890.1 

    3 DOTS entries:

    DT.101978391  DT.40118847  DT.121368393 

    17 AceView cDNA sequences:

    BC043608 AA347217 BX956657 AK097903 AK124031 AA347216 AK128377 BX640890 
    CD521591 AK094863 BM925778 AA309802 BF379806 CD704340 BF824839 CD695427 
    BX427339 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for THEMIS    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8
    SP1:                                                                  
    SP2:                          -     -                                 
    SP3:                          -     -                                 
    SP4:        -                 -     -                                 


    ECgene alternative splicing isoforms for THEMIS

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    THEMIS expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTCACCTATT
    THEMIS Expression
    About this image


    THEMIS expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Neurons
             Type1 Off Cone Bipolar Cells Inner Nuclear Layer
     
     Eye (Sensory Organs)
             Type1 Off Cone Bipolar Cells Inner Nuclear Layer
     
     Thymus (Hematopoietic System)
    THEMIS Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    THEMIS Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.661756
        Custom PCR Arrays for THEMIS
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for THEMIS
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat THEMIS
    QuantiTect SYBR Green Assays in human, mouse, rat THEMIS
    QuantiFast Probe-based Assays in human, mouse, rat THEMIS
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for THEMIS

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for THEMIS gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Themis1 , 5 thymocyte selection associated1, 5 82.93(n)1
    81.28(a)1
      10 (16.06 cM)5
    2107571  NM_178666.51  NP_848781.11 
     286683605 
    chicken
    (Gallus gallus)
    Aves THEMIS1 thymocyte selection associated 69.32(n)
    64.81(a)
      769224  XM_001232458.3  XP_001232459.3 
    lizard
    (Anolis carolinensis)
    Reptilia THEMIS6
    thymocyte selection associated
    48(a)
    1 ↔ 1
    GL343358.1(186260-346795)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia themis1 thymocyte selection associated 61.01(n)
    53.1(a)
      100496964  XM_002940393.2  XP_002940439.2 
    zebrafish
    (Danio rerio)
    Actinopterygii themis1 thymocyte selection associated 52.53(n)
    41.83(a)
      555433  XM_677933.4  XP_683025.3 


    ENSEMBL Gene Tree for THEMIS (if available)
    TreeFam Gene Tree for THEMIS (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for THEMIS gene
    THEMIS22  
    5 SIMAP similar genes for THEMIS using alignment to 2 protein entries:     THMS1_HUMAN (see all proteins):
    AURA2    FAM3A    NF2    ZNF564    THEMIS2

    Find genes that share paralogs with THEMIS           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for THEMIS
    PGOHUM00000234982


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for THEMIS (see all 4055)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1461730251,2
    Cuntested1128137566(+) TTAGCA/G/TATCTC 6 I syn11NA 4550
    rs2019869821,2
    C--125639804(+) AAAAA-/CAAAAC 3 -- int10--------
    rs2013423121,2
    C--125657456(+) TCCCT-/CCCTC 
            
    CCTCC
    3 -- int10--------
    rs1434555071,2
    C--125661937(+) GGCAT-/TTTTTT 3 -- int10--------
    rs1997302341,2
    C--125664711(+) TTTTT-/TGGAGA 3 -- int10--------
    rs1995993411,2
    C--125678872(+) CTCTC-/AAGTGG 3 -- int10--------
    rs1435216701,2
    C--125682749(+) TCTAT-/CTATCT 3 -- int10--------
    rs1390612321,2
    C--125682772(+) TCTAT-/TATC  
            
    TATCT
    3 -- int10--------
    rs1471263331,2
    --125685627(+) TAGAT-/AGAGATA 3 -- int10--------
    rs3741182811,2
    C--125685628(+) GATAG-/ATAGATA 3 -- int10--------

    HapMap Linkage Disequilibrium report for THEMIS (128029217 - 128239776 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for THEMIS (see all 12):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2664026CNV Deletion23128226
    esv2484840CNV Deletion19546169
    esv1510942CNV Insertion17803354
    esv1281893CNV Insertion17803354
    nsv830799CNV Loss17160897
    nsv525919CNV Loss19592680
    nsv518548CNV Loss19592680
    nsv483139CNV Gain15286789
    nsv819539CNV Gain19587683
    nsv886639CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing THEMIS
    DNA2.0 Custom Variant and Variant Library Synthesis for THEMIS

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 613607    OMIM disorders: --


    Find genes that share disorders with THEMIS           About GenesLikeMe

    Genetic Association Database (GAD): THEMIS
    Human Genome Epidemiology (HuGE) Navigator: THEMIS (5 documents)

    Export disorders for THEMIS gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for THEMIS gene, integrated from 10 sources (see all 28):
    (articles sorted by number of sources associating them with THEMIS)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Novel breast cancer risk alleles and interaction with ionizing radiation among U.S. radiologic technologists. (PubMed id 20095854)1, 4 Bhatti P....Sigurdson A.J. (Radiat. Res. 2010)
    2. Multiple common variants for celiac disease influencing immune gene expression. (PubMed id 20190752)1, 4 Dubois P.C....van Heel D.A. (Nat. Genet. 2010)
    3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    4. Themis is a member of a new metazoan gene family and is required for the completion of thymocyte positive selection. (PubMed id 19597497)1, 3 Johnson A.L....Schwartz R.H. (Nat. Immunol. 2009)
    5. Themis, a T cell-specific protein important for late thymocyte development. (PubMed id 19597498)1, 3 Lesourne R....Love P.E. (Nat. Immunol. 2009)
    6. Themis controls thymocyte selection through regulation of T cell antigen receptor-mediated signaling. (PubMed id 19597499)1, 3 Fu G....Gascoigne N.R. (Nat. Immunol. 2009)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    8. Generalization of Variants Identified by Genome-Wide Association Studies for Electrocardiographic Traits in African Americans. (PubMed id 23534349)1 Jeff J.M....Crawford D.C. (Ann. Hum. Genet. 2013)
    9. A Y2H-seq approach defines the human protein methyltransferase interactome. (PubMed id 23455924)1 Weimann M.... Stelzl U. (Nat. Methods 2013)
    10. GRB2-mediated recruitment of THEMIS to LAT is essential for thymocyte development. (PubMed id 23460737)1 Paster W....Acuto O. (J. Immunol. 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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      Query String
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 387357 HGNC: 21569 AceView: C6orf190 Ensembl:ENSG00000172673 euGenes: HUgn387357
    ECgene: THEMIS H-InvDB: THEMIS

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for THEMIS Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for THEMIS gene:
    Search GeneIP for patents involving THEMIS

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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