Aliases for THEMIS Gene
External Ids for THEMIS Gene
Previous HGNC Symbols for THEMIS Gene
Previous GeneCards Identifiers for THEMIS Gene
This gene encodes a protein that plays a regulatory role in both positive and negative T-cell selection during late thymocyte development. The protein functions through T-cell antigen receptor signaling, and is necessary for proper lineage commitment and maturation of T-cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2009]
GeneCards Summary for THEMIS Gene
THEMIS (Thymocyte Selection Associated) is a Protein Coding gene. An important paralog of this gene is THEMIS2.
UniProtKB/Swiss-Prot for THEMIS Gene
Plays a central role in late thymocyte development by controlling both positive and negative T-cell selection. Required to sustain and/or integrate signals required for proper lineage commitment and maturation of T-cells. Regulates T-cell development through T-cell antigen receptor (TCR) signaling and in particular through the regulation of calcium influx and phosphorylation of Erk.