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Aliases for THEM6 Gene

Aliases for THEM6 Gene

  • Thioesterase Superfamily Member 6 2 3 4 5
  • Mesenchymal Stem Cell Protein DSCD75 3 4
  • C8orf55 3 4
  • Chromosome 8 Open Reading Frame 55 2
  • UPF0670 Protein C8orf55 3
  • UPF0670 Protein THEM6 3
  • Protein THEM6 3
  • DSCD75 3

External Ids for THEM6 Gene

Previous HGNC Symbols for THEM6 Gene

  • C8orf55

Previous GeneCards Identifiers for THEM6 Gene

  • GC08P143808

Summaries for THEM6 Gene

GeneCards Summary for THEM6 Gene

THEM6 (Thioesterase Superfamily Member 6) is a Protein Coding gene. Diseases associated with THEM6 include Discharging Ear.

Additional gene information for THEM6 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for THEM6 Gene

Genomics for THEM6 Gene

Regulatory Elements for THEM6 Gene

Enhancers for THEM6 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08H142737 1.6 Ensembl ENCODE dbSUPER 16.5 +11.9 11885 2 MLX ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF766 ZNF143 ZNF207 LY6K THEM6 ZNF623 JRK SLURP1 ZNF696 EEF1D TSNARE1 PIR37820
GH08H142674 1.5 Ensembl ENCODE dbSUPER 14.5 -47.5 -47453 10 HDGF ATF1 SIN3A ZBTB7B TCF12 GLIS2 ZNF143 FOS DEK PPARG LY6K PSCA THEM6 SLURP1 JRK
GH08H142762 0.9 ENCODE 18.8 +36.3 36345 1 ELF3 PKNOX1 FOXA2 MLX ZSCAN9 RAD21 RARA ATF7 CREM THAP11 LYNX1 THEM6 PIR62770 GC08M142768 ENSG00000253196
GH08H142731 1.2 FANTOM5 Ensembl ENCODE 14 +4.9 4944 1 HDGF YBX1 NR2F2 IKZF1 ZNF512 TARDBP NBN MLLT1 RUNX3 PRDM1 LY6K SLURP1 THEM6 ENSG00000253715 LY6D GPIHBP1 LYNX1 PIR37820 ENSG00000253806
GH08H142698 1.2 Ensembl ENCODE 13.4 -27.2 -27170 3 TBP ARNT INSM2 KLF17 FEZF1 ZNF2 ZEB1 GLIS2 SCRT2 ZNF391 LY6K THEM6 SLURP1 PSCA LYPD2 PIR40452
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around THEM6 on UCSC Golden Path with GeneCards custom track

Promoters for THEM6 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000231986 97 1801 PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 ZNF207 ZNF143

Genomic Location for THEM6 Gene

Chromosome:
8
Start:
142,727,203 bp from pter
End:
142,736,932 bp from pter
Size:
9,730 bases
Orientation:
Plus strand

Genomic View for THEM6 Gene

Genes around THEM6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
THEM6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for THEM6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for THEM6 Gene

Proteins for THEM6 Gene

  • Protein details for THEM6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WUY1-THEM6_HUMAN
    Recommended name:
    Protein THEM6
    Protein Accession:
    Q8WUY1
    Secondary Accessions:
    • B2RDN6
    • Q8NBN2
    • Q9NYI2

    Protein attributes for THEM6 Gene

    Size:
    208 amino acids
    Molecular mass:
    23865 Da
    Quaternary structure:
    No Data Available

neXtProt entry for THEM6 Gene

Post-translational modifications for THEM6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for THEM6 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for THEM6 Gene

Domains & Families for THEM6 Gene

Gene Families for THEM6 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for THEM6 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for THEM6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8WUY1

UniProtKB/Swiss-Prot:

THEM6_HUMAN :
  • Belongs to the THEM6 family.
Family:
  • Belongs to the THEM6 family.
genes like me logo Genes that share domains with THEM6: view

Function for THEM6 Gene

Phenotypes From GWAS Catalog for THEM6 Gene

genes like me logo Genes that share phenotypes with THEM6: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for THEM6
  • Applied Biological Materials Clones for THEM6
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for THEM6 Gene

Localization for THEM6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for THEM6 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for THEM6 gene
Compartment Confidence
extracellular 5
nucleus 2
cytosol 2
plasma membrane 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nuclear speckles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for THEM6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with THEM6: view

Pathways & Interactions for THEM6 Gene

SuperPathways for THEM6 Gene

No Data Available

Interacting Proteins for THEM6 Gene

Gene Ontology (GO) - Biological Process for THEM6 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for THEM6 Gene

Drugs & Compounds for THEM6 Gene

No Compound Related Data Available

Transcripts for THEM6 Gene

Unigene Clusters for THEM6 Gene

Thioesterase superfamily member 6:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for THEM6
  • Applied Biological Materials Clones for THEM6
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for THEM6 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3
SP1:
SP2: -
SP3: - -

Relevant External Links for THEM6 Gene

GeneLoc Exon Structure for
THEM6
ECgene alternative splicing isoforms for
THEM6

Expression for THEM6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for THEM6 Gene

Protein differential expression in normal tissues from HIPED for THEM6 Gene

This gene is overexpressed in Nasal epithelium (53.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for THEM6 Gene



Protein tissue co-expression partners for THEM6 Gene

NURSA nuclear receptor signaling pathways regulating expression of THEM6 Gene:

THEM6

SOURCE GeneReport for Unigene cluster for THEM6 Gene:

Hs.368402

Evidence on tissue expression from TISSUES for THEM6 Gene

  • Nervous system(4.3)
  • Liver(4.2)
  • Muscle(4.1)
genes like me logo Genes that share expression patterns with THEM6: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for THEM6 Gene

Orthologs for THEM6 Gene

This gene was present in the common ancestor of animals.

Orthologs for THEM6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia THEM6 33 34
  • 99.68 (n)
cow
(Bos Taurus)
Mammalia THEM6 33 34
  • 86.24 (n)
dog
(Canis familiaris)
Mammalia THEM6 34
  • 86 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Them6 33
  • 84.57 (n)
mouse
(Mus musculus)
Mammalia Them6 33 16 34
  • 83.87 (n)
oppossum
(Monodelphis domestica)
Mammalia THEM6 34
  • 66 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia THEM6 34
  • 59 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia them6 33
  • 64.72 (n)
zebrafish
(Danio rerio)
Actinopterygii si:ch73-52e5.2 33
  • 59.32 (n)
THEM6 (1 of 2) 34
  • 50 (a)
OneToMany
THEM6 (2 of 2) 34
  • 47 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG4666 33 34
  • 52.06 (n)
CG4660 34
  • 26 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003487 33
  • 51.5 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 24 (a)
OneToOne
Species where no ortholog for THEM6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for THEM6 Gene

ENSEMBL:
Gene Tree for THEM6 (if available)
TreeFam:
Gene Tree for THEM6 (if available)

Paralogs for THEM6 Gene

No data available for Paralogs for THEM6 Gene

Variants for THEM6 Gene

Sequence variations from dbSNP and Humsavar for THEM6 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs1000052565 -- 142,735,498(+) CACAG(A/T)TGGGC nc-transcript-variant, utr-variant-3-prime
rs1000972215 -- 142,726,722(+) GGTAC(A/C)GGCTG nc-transcript-variant, upstream-variant-2KB
rs1001456886 -- 142,734,490(+) CCGCG(A/G)CTGCA intron-variant
rs1001690054 -- 142,728,264(+) GGAGT(A/T)CCCGA intron-variant, upstream-variant-2KB
rs1001886653 -- 142,734,863(+) TGGCT(A/G)TGTGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for THEM6 Gene

Variant ID Type Subtype PubMed ID
esv2661137 CNV deletion 23128226
esv2737925 CNV deletion 23290073
nsv1023021 CNV loss 25217958
nsv428207 CNV gain+loss 18775914
nsv831485 CNV loss 17160897
nsv831486 CNV gain 17160897
nsv950004 CNV deletion 24416366

Variation tolerance for THEM6 Gene

Gene Damage Index Score: 0.90; 18.71% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for THEM6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
THEM6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for THEM6 Gene

Disorders for THEM6 Gene

MalaCards: The human disease database

(1) MalaCards diseases for THEM6 Gene - From: DISEASES

Disorder Aliases PubMed IDs
discharging ear
- elite association - COSMIC cancer census association via MalaCards
Search THEM6 in MalaCards View complete list of genes associated with diseases

Relevant External Links for THEM6

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
THEM6
genes like me logo Genes that share disorders with THEM6: view

No data available for UniProtKB/Swiss-Prot and Genatlas for THEM6 Gene

Publications for THEM6 Gene

  1. Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. (PMID: 16303743) Otsuki T … Isogai T (DNA research : an international journal for rapid publication of reports on genes and genomes 2005) 3 4 60
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 60
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  5. An organelle-specific protein landscape identifies novel diseases and molecular mechanisms. (PMID: 27173435) Boldt K … UK10K Rare Diseases Group (Nature communications 2016) 3 60

Products for THEM6 Gene

  • Addgene plasmids for THEM6

Sources for THEM6 Gene

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