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Aliases for THEM6 Gene

Aliases for THEM6 Gene

  • Thioesterase Superfamily Member 6 2 3 4 5
  • Mesenchymal Stem Cell Protein DSCD75 3 4
  • C8orf55 3 4
  • Chromosome 8 Open Reading Frame 55 2
  • UPF0670 Protein C8orf55 3
  • UPF0670 Protein THEM6 3
  • Protein THEM6 3
  • DSCD75 3

External Ids for THEM6 Gene

Previous HGNC Symbols for THEM6 Gene

  • C8orf55

Previous GeneCards Identifiers for THEM6 Gene

  • GC08P143808

Summaries for THEM6 Gene

GeneCards Summary for THEM6 Gene

THEM6 (Thioesterase Superfamily Member 6) is a Protein Coding gene. Diseases associated with THEM6 include Discharging Ear.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for THEM6 Gene

Genomics for THEM6 Gene

Regulatory Elements for THEM6 Gene

Enhancers for THEM6 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08F142674 1.3 Ensembl ENCODE 14.5 -47.5 -47453 11.0 HDGF SIN3A ZNF48 GLIS2 ZNF143 FOS DEK SP5 PPARG SMARCB1 LY6K PSCA THEM6 JRK ZNF623 ZNF696 SLURP1
GH08F142737 1.1 ENCODE 16.5 +11.8 11794 2.5 HDGF MLX ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF143 ZNF207 LY6K THEM6 SLURP1 PIR37820
GH08F142762 0.9 ENCODE 18.8 +36.3 36345 1.9 ELF3 PKNOX1 MLX ZSCAN9 RAD21 RARA SCRT2 ZNF143 ZNF548 CREM LYNX1 THEM6 ZNF623 AK3P2 ENSG00000253196 GC08M142767 PIR62770
GH08F142731 1.1 FANTOM5 ENCODE 13.7 +5.0 5024 1.3 HDGF GTF2F1 PKNOX1 ESRRA SIN3A YBX1 CTBP1 GATA3 ZNF687 MTA2 LY6K SLURP1 THEM6 ENSG00000253715 LY6D GPIHBP1 LYNX1 ENSG00000253806 PIR37820
GH08F142698 0.9 ENCODE 13.4 -27.2 -27170 3.2 TBP INSM2 SIN3A KLF17 FEZF1 ZNF2 ZEB1 SCRT2 ZNF391 FOS LY6K THEM6 SLURP1 PSCA LYPD2 PIR40452
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around THEM6 on UCSC Golden Path with GeneCards custom track

Promoters for THEM6 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001403906 197 2401 PKNOX1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF207 ZNF143 ZNF548 FOS

Genomic Location for THEM6 Gene

142,727,203 bp from pter
142,736,932 bp from pter
9,730 bases
Plus strand

Genomic View for THEM6 Gene

Genes around THEM6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
THEM6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for THEM6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for THEM6 Gene

Proteins for THEM6 Gene

  • Protein details for THEM6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein THEM6
    Protein Accession:
    Secondary Accessions:
    • B2RDN6
    • Q8NBN2
    • Q9NYI2

    Protein attributes for THEM6 Gene

    208 amino acids
    Molecular mass:
    23865 Da
    Quaternary structure:
    No Data Available

neXtProt entry for THEM6 Gene

Post-translational modifications for THEM6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for THEM6 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for THEM6 Gene

Domains & Families for THEM6 Gene

Protein Domains for THEM6 Gene


Suggested Antigen Peptide Sequences for THEM6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the THEM6 family.
  • Belongs to the THEM6 family.
genes like me logo Genes that share domains with THEM6: view

No data available for Gene Families for THEM6 Gene

Function for THEM6 Gene

genes like me logo Genes that share phenotypes with THEM6: view

Animal Model Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for THEM6

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for THEM6 Gene

Localization for THEM6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for THEM6 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for THEM6 gene
Compartment Confidence
extracellular 5
nucleus 2
cytosol 2
plasma membrane 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for THEM6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with THEM6: view

Pathways & Interactions for THEM6 Gene

SuperPathways for THEM6 Gene

No Data Available

Interacting Proteins for THEM6 Gene

STRING Interaction Network Preview (showing 4 interactants - click image to see details)
Selected Interacting proteins: ENSP00000338607 Q8WUY1-THEM6_HUMAN for THEM6 Gene via STRING IID

Gene Ontology (GO) - Biological Process for THEM6 Gene


No data available for Pathways by source and SIGNOR curated interactions for THEM6 Gene

Transcripts for THEM6 Gene

Unigene Clusters for THEM6 Gene

Thioesterase superfamily member 6:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for THEM6

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for THEM6 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3
SP2: -
SP3: - -

Relevant External Links for THEM6 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for THEM6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for THEM6 Gene

Protein differential expression in normal tissues from HIPED for THEM6 Gene

This gene is overexpressed in Nasal epithelium (53.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for THEM6 Gene

Protein tissue co-expression partners for THEM6 Gene

NURSA nuclear receptor signaling pathways regulating expression of THEM6 Gene:


SOURCE GeneReport for Unigene cluster for THEM6 Gene:

genes like me logo Genes that share expression patterns with THEM6: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for THEM6 Gene

Orthologs for THEM6 Gene

This gene was present in the common ancestor of animals.

Orthologs for THEM6 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia THEM6 34 35
  • 99.68 (n)
(Bos Taurus)
Mammalia THEM6 34 35
  • 86.24 (n)
(Canis familiaris)
Mammalia THEM6 35
  • 86 (a)
(Rattus norvegicus)
Mammalia Them6 34
  • 84.57 (n)
(Mus musculus)
Mammalia Them6 34 16 35
  • 83.87 (n)
(Monodelphis domestica)
Mammalia THEM6 35
  • 66 (a)
(Anolis carolinensis)
Reptilia THEM6 35
  • 59 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia them6 34
  • 64.72 (n)
(Danio rerio)
Actinopterygii si:ch73-52e5.2 34
  • 59.32 (n)
THEM6 (1 of 2) 35
  • 50 (a)
THEM6 (2 of 2) 35
  • 47 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG4666 34 35
  • 52.06 (n)
CG4660 35
  • 26 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003487 34
  • 51.5 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 24 (a)
Species where no ortholog for THEM6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for THEM6 Gene

Gene Tree for THEM6 (if available)
Gene Tree for THEM6 (if available)

Paralogs for THEM6 Gene

No data available for Paralogs for THEM6 Gene

Variants for THEM6 Gene

Sequence variations from dbSNP and Humsavar for THEM6 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs10087426 -- 142,733,136(+) gcaac(A/G)tacaa intron-variant
rs10101294 -- 142,728,959(+) ttttc(A/G)gacgg intron-variant, upstream-variant-2KB, splice-acceptor-variant
rs10103654 -- 142,732,163(+) TTGAA(C/T)ATATA intron-variant
rs10624245 -- 142,734,279(+) GACTC(-/TG)TATGT intron-variant
rs10956983 -- 142,730,515(+) CAGGG(G/T)ACACT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for THEM6 Gene

Variant ID Type Subtype PubMed ID
nsv950004 CNV deletion 24416366
nsv831486 CNV gain 17160897
nsv831485 CNV loss 17160897
nsv428207 CNV gain+loss 18775914
nsv1023021 CNV loss 25217958
esv2737925 CNV deletion 23290073
esv2661137 CNV deletion 23128226

Variation tolerance for THEM6 Gene

Gene Damage Index Score: 0.90; 18.71% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for THEM6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for THEM6 Gene

Disorders for THEM6 Gene

MalaCards: The human disease database

(1) MalaCards diseases for THEM6 Gene - From: DISEASES

Disorder Aliases PubMed IDs
discharging ear
- elite association - COSMIC cancer census association via MalaCards
Search THEM6 in MalaCards View complete list of genes associated with diseases

Relevant External Links for THEM6

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with THEM6: view

No data available for UniProtKB/Swiss-Prot and Genatlas for THEM6 Gene

Publications for THEM6 Gene

  1. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PMID: 16303743) Otsuki T. … Isogai T. (DNA Res. 2005) 3 4 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  5. A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface. (PMID: 26638075) Gupta G.D. … Pelletier L. (Cell 2015) 3 64

Products for THEM6 Gene

Sources for THEM6 Gene

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