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Aliases for THEM6 Gene

Aliases for THEM6 Gene

  • Thioesterase Superfamily Member 6 2 3 4
  • Mesenchymal Stem Cell Protein DSCD75 3 4
  • C8orf55 3 4
  • Chromosome 8 Open Reading Frame 55 2
  • UPF0670 Protein C8orf55 3
  • UPF0670 Protein THEM6 3
  • Protein THEM6 3
  • DSCD75 3

External Ids for THEM6 Gene

Previous Symbols for THEM6 Gene

  • C8orf55

Summaries for THEM6 Gene

GeneCards Summary for THEM6 Gene

THEM6 (Thioesterase Superfamily Member 6) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for THEM6 Gene

Genomics for THEM6 Gene

Genomic Location for THEM6 Gene

Start:
142,727,203 bp from pter
End:
142,736,932 bp from pter
Size:
9,730 bases
Orientation:
Plus strand

Genomic View for THEM6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for THEM6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for THEM6 Gene

No data available for Regulatory Elements for THEM6 Gene

Proteins for THEM6 Gene

  • Protein details for THEM6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WUY1-THEM6_HUMAN
    Recommended name:
    Protein THEM6
    Protein Accession:
    Q8WUY1
    Secondary Accessions:
    • B2RDN6
    • Q8NBN2
    • Q9NYI2

    Protein attributes for THEM6 Gene

    Size:
    208 amino acids
    Molecular mass:
    23865 Da
    Quaternary structure:
    No Data Available

neXtProt entry for THEM6 Gene

Proteomics data for THEM6 Gene at MOPED

Post-translational modifications for THEM6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for THEM6 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for THEM6 Gene

Domains for THEM6 Gene

Protein Domains for THEM6 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

THEM6_HUMAN
Family:
  • Belongs to the THEM6 family.:
    • Q8WUY1
genes like me logo Genes that share domains with THEM6: view

No data available for Gene Families for THEM6 Gene

Function for THEM6 Gene

Phenotypes for THEM6 Gene

GenomeRNAi human phenotypes for THEM6:
genes like me logo Genes that share phenotypes with THEM6: view

miRNA for THEM6 Gene

miRTarBase miRNAs that target THEM6

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targeting and HOMER Transcription for THEM6 Gene

Localization for THEM6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for THEM6 Gene

Secreted.

Gene Ontology (GO) - Cellular Components for THEM6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with THEM6: view

Pathways for THEM6 Gene

SuperPathways for THEM6 Gene

No Data Available

Interacting Proteins for THEM6 Gene

STRING Interaction Network Preview (showing 4 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000338607%0d%0a9606.ENSP00000377252%0d%0a9606.ENSP00000221138%0d%0a9606.ENSP00000418447%0d%0a9606.ENSP00000279387%0d%0a
Selected Interacting proteins: ENSP00000338607 Q8WUY1-THEM6_HUMAN for THEM6 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for THEM6 Gene

None

No data available for Pathways by source for THEM6 Gene

Transcripts for THEM6 Gene

Unigene Clusters for THEM6 Gene

Thioesterase superfamily member 6:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for THEM6 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3
SP1:
SP2: -
SP3: - -

Relevant External Links for THEM6 Gene

GeneLoc Exon Structure for
THEM6
ECgene alternative splicing isoforms for
THEM6

Expression for THEM6 Gene

mRNA expression in normal human tissues for THEM6 Gene

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for THEM6 Gene

SOURCE GeneReport for Unigene cluster for THEM6 Gene Hs.368402

genes like me logo Genes that share expressions with THEM6: view

Orthologs for THEM6 Gene

This gene was present in the common ancestor of animals.

Orthologs for THEM6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia THEM6 36
  • 99.68 (n)
  • 100 (a)
THEM6 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia THEM6 36
  • 86.24 (n)
  • 86.77 (a)
THEM6 37
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia THEM6 37
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Them6 36
  • 83.87 (n)
  • 89.36 (a)
Them6 16
Them6 37
  • 88 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia THEM6 37
  • 66 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Them6 36
  • 84.57 (n)
  • 88.83 (a)
lizard
(Anolis carolinensis)
Reptilia THEM6 37
  • 59 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia them6 36
  • 64.72 (n)
  • 60.64 (a)
zebrafish
(Danio rerio)
Actinopterygii si:ch73-52e5.2 36
  • 59.32 (n)
  • 53.23 (a)
THEM6 (1 of 2) 37
  • 50 (a)
OneToMany
THEM6 (2 of 2) 37
  • 47 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003487 36
  • 51.5 (n)
  • 35.39 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG4660 37
  • 26 (a)
OneToMany
CG4666 36
  • 52.06 (n)
  • 37.08 (a)
CG4666 37
  • 36 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 24 (a)
OneToOne
Species with no ortholog for THEM6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for THEM6 Gene

ENSEMBL:
Gene Tree for THEM6 (if available)
TreeFam:
Gene Tree for THEM6 (if available)

Paralogs for THEM6 Gene

No data available for Paralogs for THEM6 Gene

Variants for THEM6 Gene

Sequence variations from dbSNP and Humsavar for THEM6 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs749610 -- 142,737,085(+) AGGCT(C/G)GCAGG downstream-variant-500B
rs2572912 -- 142,732,474(+) agaac(C/T)ggaac intron-variant
rs2572913 -- 142,733,121(+) tgtcc(C/G)gattg intron-variant
rs2585134 -- 142,734,117(-) atgat(A/G)gaaga intron-variant
rs2585135 -- 142,732,775(-) gaaat(C/T)gagac intron-variant

Relevant External Links for THEM6 Gene

HapMap Linkage Disequilibrium report
THEM6

No data available for Structural Variations from Database of Genomic Variants (DGV) for THEM6 Gene

Disorders for THEM6 Gene

No disorders were found for THEM6 Gene.

No data available for UniProtKB/Swiss-Prot for THEM6 Gene

Publications for THEM6 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PMID: 16303743) Otsuki T. … Isogai T. (DNA Res. 2005) 3 4
  4. Transcriptome analysis of human gastric cancer. (PMID: 16341674) Oh J.H. … Kim N.S. (Mamm. Genome 2005) 3
  5. Hsp90 cochaperone Aha1 downregulation rescues misfolding of CFTR in cystic fibrosis. (PMID: 17110338) Wang X. … Balch W.E. (Cell 2006) 3

Products for THEM6 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate THEM6
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for THEM6
    • Block miRNA regulation of THEM6 using miScript Target Protectors

    Sources for THEM6 Gene

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