Aliases for THEM5 Gene
External Ids for THEM5 Gene
Previous GeneCards Identifiers for THEM5 Gene
GeneCards Summary for THEM5 Gene
THEM5 (Thioesterase Superfamily Member 5) is a Protein Coding gene. Diseases associated with THEM5 include median rhomboid glossitis and geographic tongue. Among its related pathways are Metabolism and Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha). GO annotations related to this gene include palmitoyl-CoA hydrolase activity. An important paralog of this gene is THEM4.
UniProtKB/Swiss-Prot for THEM5 Gene
Has acyl-CoA thioesterase activity towards long-chain (C16 and C18) fatty acyl-CoA substrates, with a preference for linoleyl-CoA and other unsaturated long-chain fatty acid-CoA esters. Plays an important role in mitochondrial fatty acid metabolism, and in remodeling of the mitochondrial lipid cardiolipin. Required for normal mitochondrial function.