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Aliases for THEM5 Gene

Aliases for THEM5 Gene

  • Thioesterase Superfamily Member 5 2 3 4 5
  • Acyl-Coenzyme A Thioesterase 15 3 4
  • Acyl-CoA Thioesterase THEM5 3 4
  • ACOT15 3 4
  • Acyl-Coenzyme A Thioesterase THEM5 3
  • EC 3.1.2.2 4

External Ids for THEM5 Gene

Previous GeneCards Identifiers for THEM5 Gene

  • GC01M148632
  • GC01M150084
  • GC01M151818
  • GC01M123196
  • GC01M151819

Summaries for THEM5 Gene

GeneCards Summary for THEM5 Gene

THEM5 (Thioesterase Superfamily Member 5) is a Protein Coding gene. Diseases associated with THEM5 include Median Rhomboid Glossitis and Geographic Tongue. Among its related pathways are Metabolism and Fatty Acyl-CoA Biosynthesis. GO annotations related to this gene include palmitoyl-CoA hydrolase activity. An important paralog of this gene is THEM4.

UniProtKB/Swiss-Prot for THEM5 Gene

  • Has acyl-CoA thioesterase activity towards long-chain (C16 and C18) fatty acyl-CoA substrates, with a preference for linoleyl-CoA and other unsaturated long-chain fatty acid-CoA esters. Plays an important role in mitochondrial fatty acid metabolism, and in remodeling of the mitochondrial lipid cardiolipin. Required for normal mitochondrial function.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for THEM5 Gene

Genomics for THEM5 Gene

Regulatory Elements for THEM5 Gene

Enhancers for THEM5 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F151818 1 FANTOM5 Ensembl ENCODE 11.3 +33.3 33307 3.2 SUZ12 HINFP ZNF335 ZNF121 GLIS2 ZBTB48 ELK1 SCRT2 PATZ1 ZNF600 ENSG00000203288 TDRKH C2CD4D ENSG00000201134 THEM5 ENSG00000232937 MRPL9 OAZ3 RPS10P6 TUFT1
GH01F151891 0.8 ENCODE 11.1 -38.0 -38043 0.2 ARID1B NCOR1 TAL1 KDM1A THEM4 ENSG00000229021 S100A10 THEM5 PIR59936 PIR54702
GH01F151897 1 FANTOM5 Ensembl ENCODE 10.9 -44.7 -44734 1.9 ZNF687 MAFG ZNF316 CTBP1 NONO GATA3 MTA3 ZBTB48 PBX2 ZNF341 THEM4 THEM5 PIR59936
GH01F151934 1.2 FANTOM5 Ensembl ENCODE 10.9 -82.1 -82135 3.4 HDGF PKNOX1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 SLC30A9 ZNF766 MRPL9 THEM4 GABPB2 ENSG00000229021 S100A10 LINGO4 THEM5 HRNR RPS10P6 C1orf56
GH01F151885 1 ENCODE 10.8 -33.2 -33171 3.2 ZNF362 SP3 JUN MNT DPF2 ZIC2 GATA3 CTBP1 ZNF366 IKZF1 THEM4 ENSG00000229021 S100A10 THEM5 PIR59936 PIR54702
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around THEM5 on UCSC Golden Path with GeneCards custom track

Genomic Location for THEM5 Gene

Chromosome:
1
Start:
151,847,101 bp from pter
End:
151,853,697 bp from pter
Size:
6,597 bases
Orientation:
Minus strand

Genomic View for THEM5 Gene

Genes around THEM5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
THEM5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for THEM5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for THEM5 Gene

Proteins for THEM5 Gene

  • Protein details for THEM5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N1Q8-ACO15_HUMAN
    Recommended name:
    Acyl-coenzyme A thioesterase THEM5
    Protein Accession:
    Q8N1Q8
    Secondary Accessions:
    • Q5T1C3

    Protein attributes for THEM5 Gene

    Size:
    247 amino acids
    Molecular mass:
    27677 Da
    Quaternary structure:
    • Homodimer.

    Three dimensional structures from OCA and Proteopedia for THEM5 Gene

neXtProt entry for THEM5 Gene

Post-translational modifications for THEM5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for THEM5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for THEM5 Gene

Domains & Families for THEM5 Gene

Protein Domains for THEM5 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for THEM5 Gene

Graphical View of Domain Structure for InterPro Entry

Q8N1Q8

UniProtKB/Swiss-Prot:

ACO15_HUMAN :
  • Belongs to the THEM4/THEM5 thioesterase family.
Family:
  • Belongs to the THEM4/THEM5 thioesterase family.
genes like me logo Genes that share domains with THEM5: view

No data available for Gene Families for THEM5 Gene

Function for THEM5 Gene

Molecular function for THEM5 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=2.4 uM for palmitoyl-CoA (C16:0) {ECO:0000269 PubMed:22586271}; KM=4.2 uM for stearoyl-CoA (C18:0) {ECO:0000269 PubMed:22586271}; KM=2.9 uM for oleoyl-CoA (C18:1) {ECO:0000269 PubMed:22586271}; KM=4.2 uM for linoleyl-CoA (C18:2) {ECO:0000269 PubMed:22586271};
UniProtKB/Swiss-Prot CatalyticActivity:
Palmitoyl-CoA + H(2)O = CoA + palmitate.
UniProtKB/Swiss-Prot Function:
Has acyl-CoA thioesterase activity towards long-chain (C16 and C18) fatty acyl-CoA substrates, with a preference for linoleyl-CoA and other unsaturated long-chain fatty acid-CoA esters. Plays an important role in mitochondrial fatty acid metabolism, and in remodeling of the mitochondrial lipid cardiolipin. Required for normal mitochondrial function.

Enzyme Numbers (IUBMB) for THEM5 Gene

Gene Ontology (GO) - Molecular Function for THEM5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0016290 palmitoyl-CoA hydrolase activity IEA,IDA 22586271
GO:0016787 hydrolase activity IEA --
GO:0047617 acyl-CoA hydrolase activity TAS --
genes like me logo Genes that share ontologies with THEM5: view
genes like me logo Genes that share phenotypes with THEM5: view

Animal Models for THEM5 Gene

MGI Knock Outs for THEM5:

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for THEM5 Gene

Localization for THEM5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for THEM5 Gene

Mitochondrion matrix.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for THEM5 Gene COMPARTMENTS Subcellular localization image for THEM5 gene
Compartment Confidence
mitochondrion 5
cytosol 2
extracellular 1
golgi apparatus 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for THEM5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005759 mitochondrial matrix TAS --
genes like me logo Genes that share ontologies with THEM5: view

Pathways & Interactions for THEM5 Gene

genes like me logo Genes that share pathways with THEM5: view

Interacting Proteins for THEM5 Gene

Gene Ontology (GO) - Biological Process for THEM5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process IEA --
GO:0006631 fatty acid metabolic process IEA --
GO:0035336 long-chain fatty-acyl-CoA metabolic process IDA 22586271
GO:0035338 long-chain fatty-acyl-CoA biosynthetic process TAS --
GO:0035965 cardiolipin acyl-chain remodeling IEA,ISS --
genes like me logo Genes that share ontologies with THEM5: view

No data available for SIGNOR curated interactions for THEM5 Gene

Drugs & Compounds for THEM5 Gene

(3) Drugs for THEM5 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Water Approved Pharma 0
Palmitic Acid Experimental Pharma Full agonist, Agonist 22
Coenzyme A Nutra 0

(1) Additional Compounds for THEM5 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
hexadecanoyl-CoA
genes like me logo Genes that share compounds with THEM5: view

Transcripts for THEM5 Gene

mRNA/cDNA for THEM5 Gene

(2) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(3) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for THEM5 Gene

Thioesterase superfamily member 5:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for THEM5 Gene

No ASD Table

Relevant External Links for THEM5 Gene

GeneLoc Exon Structure for
THEM5
ECgene alternative splicing isoforms for
THEM5

Expression for THEM5 Gene

mRNA expression in normal human tissues for THEM5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for THEM5 Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (x24.7) and Skin - Not Sun Exposed (Suprapubic) (x19.1).

Protein differential expression in normal tissues from HIPED for THEM5 Gene

This gene is overexpressed in Skin (43.9) and Heart (25.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for THEM5 Gene



Protein tissue co-expression partners for THEM5 Gene

NURSA nuclear receptor signaling pathways regulating expression of THEM5 Gene:

THEM5

SOURCE GeneReport for Unigene cluster for THEM5 Gene:

Hs.132648
genes like me logo Genes that share expression patterns with THEM5: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for THEM5 Gene

Orthologs for THEM5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for THEM5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia THEM5 34 35
  • 96.21 (n)
dog
(Canis familiaris)
Mammalia THEM5 34 35
  • 86.5 (n)
rat
(Rattus norvegicus)
Mammalia Them5 34
  • 83.47 (n)
mouse
(Mus musculus)
Mammalia Them5 34 16 35
  • 83.4 (n)
cow
(Bos Taurus)
Mammalia THEM5 34 35
  • 80.14 (n)
oppossum
(Monodelphis domestica)
Mammalia THEM5 35
  • 61 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia THEM5 35
  • 50 (a)
OneToOne
chicken
(Gallus gallus)
Aves -- 35
  • 32 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 30 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii THEM4 35
  • 29 (a)
OneToMany
Species where no ortholog for THEM5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for THEM5 Gene

ENSEMBL:
Gene Tree for THEM5 (if available)
TreeFam:
Gene Tree for THEM5 (if available)

Paralogs for THEM5 Gene

Paralogs for THEM5 Gene

(1) SIMAP similar genes for THEM5 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with THEM5: view

Variants for THEM5 Gene

Sequence variations from dbSNP and Humsavar for THEM5 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1056037 -- 151,851,521(+) TAATA(C/G)TAAAC intron-variant
rs111260545 -- 151,850,035(+) CACAG(C/T)CTAGT intron-variant
rs111583050 -- 151,853,376(+) GAGAT(A/T)TGGGG intron-variant
rs111615522 -- 151,849,698(+) GAAAA(G/T)AGTTG intron-variant
rs112273666 -- 151,847,147(+) TCCCT(C/T)GCCTC reference, synonymous-codon, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for THEM5 Gene

Variant ID Type Subtype PubMed ID
esv2717906 CNV deletion 23290073
esv2717918 CNV deletion 23290073
nsv516369 CNV gain 19592680

Variation tolerance for THEM5 Gene

Residual Variation Intolerance Score: 75.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.68; 46.07% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for THEM5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
THEM5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for THEM5 Gene

Disorders for THEM5 Gene

MalaCards: The human disease database

(2) MalaCards diseases for THEM5 Gene - From: DISEASES

Disorder Aliases PubMed IDs
median rhomboid glossitis
  • persistent tuberculum impar
geographic tongue
  • benign migratory glossitis
- elite association - COSMIC cancer census association via MalaCards
Search THEM5 in MalaCards View complete list of genes associated with diseases

Relevant External Links for THEM5

Genetic Association Database (GAD)
THEM5
Human Genome Epidemiology (HuGE) Navigator
THEM5
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
THEM5
genes like me logo Genes that share disorders with THEM5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for THEM5 Gene

Publications for THEM5 Gene

  1. Acyl coenzyme A thioesterase Them5/Acot15 is involved in cardiolipin remodeling and fatty liver development. (PMID: 22586271) Zhuravleva E. … Hemmings B.A. (Mol. Cell. Biol. 2012) 3 4 64
  2. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 46 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 64
  5. New genetic associations detected in a host response study to hepatitis B vaccine. (PMID: 20237496) Davila S. … Seielstad M. (Genes Immun. 2010) 3 64

Products for THEM5 Gene

Sources for THEM5 Gene

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