THEM4 Gene
protein-coding GIFtS: 54
GCID: GC01M151846
|
|
thioesterase superfamily member 4
| |
Aliases
for THEM4 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Thioesterase Superfamily Member 41 2 3 | | Acyl-Coenzyme A Thioesterase THEM42 | | CTMP1 2 3 5 | | C-Terminal Modulator Protein2 | | Acyl-CoA Thioesterase THEM42 3 | | EC 3.1.2.23 | | Carboxyl-Terminal Modulator Protein2 3 | | |
Export aliases for THEM4 gene to outside databasesPrevious GC identifers: GC01M148660 GC01M150112 GC01M123223 |
Summaries
for THEM4 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for THEM4:
Protein kinase B (PKB) is a major downstream target of receptor tyrosine kinases that signal via phosphatidylinositol3-kinase. Upon cell stimulation, PKB is translocated to the plasma membrane, where it is phosphorylated in theC-terminal regulatory domain. The protein encoded by this gene negatively regulates PKB activity by inhibitingphosphorylation. Transcription of this gene is commonly downregulated in glioblastomas. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: THEM4_HUMAN, Q5T1C6Function: Has acyl-CoA thioesterase activity towards medium and long-chain (C14 to C18) fatty acyl-CoA substrates, andprobably plays an role in mitochondrial fatty acid metabolism. Plays a role in the apoptotic process, possibly via itsregulation of AKT1 activity. According to PubMed:11598301, inhibits AKT1 phosphorylation and activity. According toPubMed:17615157, enhances AKT1 activity by favoring its phosphorylation and translocation to plasma membrane
|
Genomic Views
for THEM4 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_004487.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the THEM4 gene promoter:
Egr-2 S8
Other transcription factors
Search SABiosciences Chromatin IP Primers for THEM4
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat THEM4 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1q21 Ensembl cytogenetic band: 1q21.3 HGNC cytogenetic band: 1q21.3THEM4 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01M151846: view genomic region
(about GC identifiers)
Start:
|
151,846,060 bp from pter |
End:
|
151,882,284 bp from pter |
Size:
|
36,225 bases |
Orientation:
|
minus strand |
|
Proteins
for THEM4 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: THEM4_HUMAN, Q5T1C6 (See
protein sequence)Recommended Name: Acyl-coenzyme A thioesterase THEM4 precursor Size: 240 amino acids; 27130 Da
Subunit: Homodimer and homotetramer. Interacts with AKT1 in the cytosol
Subcellular location: Cell membrane. Cell projection, ruffle membrane. Cytoplasm. Mitochondrion. Mitochondrion innermembrane; Peripheral membrane protein. Mitochondrion intermembrane space. Note=Released from the mitochondria into thecytosol in response to apoptotic stimuli
2 PDB 3D structures from  and Proteopedia  for THEM4:4AE8 (3D)
4GAH (3D)
Secondary accessions: B2RBX2 Q96KR2Explore the universe of human proteins at neXtProt for THEM4: NX_Q5T1C6
Post-translational modifications:
Phosphorylated1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q5T1C6
THEM4 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_444283.2
ENSEMBL proteins: ENSP00000357804 ENSP00000431288 ENSP00000433304 Reactome Protein details: Q5T1C6
Human Recombinant Protein Products:
Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7): About this table
THEM4 for ontologies About GeneDecksing
THEM4 Antibody Products:
Assay Products for THEM4: |
Protein
Domains /
Families
for THEM4 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
THEM4 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q5T1C6ProtoNet protein and cluster: Q5T1C6 UniProtKB/Swiss-Prot: THEM4_HUMAN, Q5T1C6Similarity: Belongs to the THEM4/THEM5 thioesterase family |
Function
for THEM4 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: THEM4_HUMAN, Q5T1C6Function: Has acyl-CoA thioesterase activity towards medium and long-chain (C14 to C18) fatty acyl-CoA substrates, andprobably plays an role in mitochondrial fatty acid metabolism. Plays a role in the apoptotic process, possibly via itsregulation of AKT1 activity. According to PubMed:11598301, inhibits AKT1 phosphorylation and activity. According toPubMed:17615157, enhances AKT1 activity by favoring its phosphorylation and translocation to plasma membraneCatalytic activity: Palmitoyl-CoA + H(2)O = CoA + palmitateBiophysicochemical properties: Kinetic parameters: KM=2.4 uM for myristoyl-CoA; KM=2.6 uM for palmitoyl-CoA; KM=5.2 uMfor oleoyl-CoA;Enzyme Number (IUBMB): EC 3.1.2.21
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for THEM4 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for THEM4 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: THEM4 (NM_053055) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for THEM4 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat THEM4 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for THEM4 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016290 | palmitoyl-CoA hydrolase activity |
IDA | -- |
THEM4 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for THEM4:
Animal Models:
3 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Them4):
THEM4 for phenotypes About GeneDecksing
|
Pathways & Interactions
for THEM4 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/9 super-pathways (see all 9) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Signaling by FGFR | | | 2 | PIP3 activates AKT signaling | | | 3 | IRS-related events | | | 4 | Immune System | | | 5 | Negative regulation of the PI3K/AKT network | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 
Cell Signaling Technology (CST) Pathway for THEM4
5/38 
Reactome Pathways for THEM4 (see all 38)
THEM4 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for THEM4
STRING Interaction
Network Preview (showing 4 interactants - click image to see more details)
4 Interacting proteins for THEM4 (Q5T1C62, 3 ENSP000003578044) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006631 | fatty acid metabolic process |
IDA | -- | | GO:0006915 | apoptotic process |
IMP | 19168129 | | GO:0007173 | epidermal growth factor receptor signaling pathway |
TAS | -- | | GO:0008286 | insulin receptor signaling pathway |
TAS | -- | | GO:0008543 | fibroblast growth factor receptor signaling pathway |
TAS | -- |
THEM4 for ontologies About GeneDecksing
|
Drugs & Compounds
for THEM4 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for THEM4
Search CenterWatch for drugs/clinical trials and news about THEM4
|
Transcripts
for THEM4 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for THEM4 gene (2 alternative transcripts): NM_053055.4 NM_176853.2 Unigene Cluster for THEM4: Thioesterase superfamily member 4 Hs.164070 [show with all ESTs]Unigene Representative Sequence: NM_0530555 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000368814(uc001ezj.2 uc001ezk.2) ENST00000471464 ENST00000483207
ENST00000477437 ENST00000489410
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for THEM4 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for THEM4 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: THEM4 (NM_053055) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for THEM4 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat THEM4 |
Additional cDNA sequence: AF075119.1 AJ313515.1 AK024219.1 AK096211.1 AK130716.1 AK289494.1 AK314852.1 BC017339.2 BC065277.1 14 DOTS entries: DT.100785377 DT.95073221 DT.101958305 DT.95073218 DT.40285681 DT.109450 DT.121382313 DT.95093278 DT.100785376 DT.100785380 DT.75153948 DT.121055363 DT.75189924 DT.97773650 24/109 AceView cDNA sequences (see all 109): NM_176853 AI702843 AW014523 CA414415 BQ774123 BF196099 AA505115 BX482249 W60771 R78215 BM973487 BX390253 AW835661 BU183570 BM787449 AK024219 BI224263 BE067599 AF075119 AA402743 AK096211 AI887946 W60709 BM843221
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for THEM4 About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5a | · | 5b | · | 5c | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 |
|---|
|
| SP1: | | | | | | | - | | | | - | | - | | - | | - | | | | | | | | | | | | | | |
| SP2: | | | | | | | - | | | | - | | | | | | - | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for THEM4
|
Expression
for THEM4 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| THEM4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AATCTTTTTT
About this image
See THEM4 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for THEM4
SOURCE GeneReport for Unigene cluster: Hs.164070
UniProtKB/Swiss-Prot: THEM4_HUMAN, Q5T1C6Tissue specificity: Expressed predominantly in skeletal muscle, testis, uterus, brain and kidney. Down-regulated inglioblastoma or glioma compared to non-neoplastic brain due to promoter hypermethylation
SABiosciences Custom PCR Arrays for THEM4
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for THEM4
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat THEM4 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat THEM4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat THEM4 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for THEM4 |
Orthologs
for THEM4 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for THEM4 gene from 4/10 species (see all 10) About this table
ENSEMBL Gene Tree for THEM4 (if available)
TreeFam Gene Tree for THEM4 (if available) |
Paralogs
for THEM4 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for THEM4 gene
- THEM52
1 SIMAP similar gene for THEM4 using alignment to 3 protein entries: THEM4_HUMAN (see all proteins):THEM5
THEM4 for paralogs About GeneDecksing
2 Pseudogenes.org Pseudogenes for THEM4
PGOHUM00000239704 PGOHUM00000246791
|
Genomic Variants
for THEM4 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for THEM4 (151846060 - 151882284 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for THEM4: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing THEM4 |
|
Disorders
/ Diseases
for THEM4 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
THEM4 for disorders About GeneDecksing
OMIM gene information: 606388
OMIM disorders: --
2  diseases for THEM4: About MalaCardsglioblastoma focal cortical dysplasia
Human Genome Epidemiology (HuGE) Navigator: THEM4 (1 document)
Export disorders for THEM4 gene to outside databases
|
Publications
for THEM4 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for THEM4 gene, integrated from 9 sources (see all 21):
(articles sorted by number of sources associating them with THEM4) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Carboxyl-terminal modulator protein (CTMP), a negative regulator of PKB/Akt and v-Akt at the plasma membrane. (PubMed id 11598301)1, 2, 3 Maira S.-M....Hemmings B.A. (2001)
- Heat shock protein 70-mediated sensitization of cells to apoptosis by Carboxyl-Terminal Modulator Protein. (PubMed id 19604401)1, 2 Piao L....Park J. (2009)
- Carboxy-Terminal Modulator Protein (CTMP) is a mitochondrial protein that sensitizes cells to apoptosis. (PubMed id 19168129)1, 2 Parcellier A....Hemmings B.A. (2009)
- Carboxy-terminal modulator protein induces Akt phosphorylation and activation, thereby enhancing antiapoptotic, glycogen synthetic, and glucose uptake pathways. (PubMed id 17615157)1, 2 Ono H.... Asano T. (2007)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Hypermethylation and transcriptional downregulation of the carboxyl- terminal modulator protein gene in glioblastomas. (PubMed id 15026474)1, 2 Knobbe C.B.... Reifenberger G. (2004)
- Correlation of structure and function in the human hotdog-fold enzyme hTHEM4. (PubMed id 22871024)2 Zhao H.... Dunaway-Mariano D. (2012)
- Carboxyl-terminal modulator protein induces apoptosis by regulating mitochondrial function in lung cancer cells. (PubMed id 22200884)1 Hwang S.K....Cho M.H. (2012)
- Acyl coenzyme A thioesterase Them5/Acot15 is involved in cardiolipin remodeling and fatty liver development. (PubMed id 22586271)2 Zhuravleva E.... Hemmings B.A. (2012)
- Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1 Hendrickson S.L....O'Brien S.J. (2010)
|
External Searches for THEM4 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing THEM4 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing THEM4 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing THEM4 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for THEM4 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for THEM4 gene:
Search GeneIP for patents involving THEM4
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for THEM4 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | OriGene Antibodies for THEM4 | | OriGene shRNA RFP for THEM4 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for THEM4 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for THEM4 | | | OriGene Protein Over-expression Lysate for THEM4 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for THEM4 | | OriGene 3'-UTR Clone for THEM4 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for THEM4 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for THEM4 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for THEM4 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for THEM4 | | OriGene Custom Protein Services for THEM4 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat THEM4 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing THEM4 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat THEM4 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat THEM4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat THEM4 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat THEM4 |
| |
 |  |  |  | |
| | Antibodies & Assays for THEM4 (CTMP) |
| | | | Search Tocris compounds for THEM4 |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | THEM4 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for THEM4 |
|  |  |  | | | | ThermoFisher Antibodies for THEM4 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat THEM4 |
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