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Aliases for THEM4 Gene

Aliases for THEM4 Gene

  • Thioesterase Superfamily Member 4 2 3 4 5
  • Carboxyl-Terminal Modulator Protein 3 4
  • C-Terminal Modulator Protein 2 3
  • Acyl-CoA Thioesterase THEM4 3 4
  • CTMP 3 4
  • EC 3.1.2.2 4

External Ids for THEM4 Gene

Previous GeneCards Identifiers for THEM4 Gene

  • GC01M148660
  • GC01M150112
  • GC01M151846
  • GC01M123223

Summaries for THEM4 Gene

Entrez Gene Summary for THEM4 Gene

  • Protein kinase B (PKB) is a major downstream target of receptor tyrosine kinases that signal via phosphatidylinositol 3-kinase. Upon cell stimulation, PKB is translocated to the plasma membrane, where it is phosphorylated in the C-terminal regulatory domain. The protein encoded by this gene negatively regulates PKB activity by inhibiting phosphorylation. Transcription of this gene is commonly downregulated in glioblastomas. [provided by RefSeq, Jul 2008]

GeneCards Summary for THEM4 Gene

THEM4 (Thioesterase Superfamily Member 4) is a Protein Coding gene. Diseases associated with THEM4 include anus disease and myiasis. Among its related pathways are Signaling by GPCR and Metabolism. GO annotations related to this gene include palmitoyl-CoA hydrolase activity. An important paralog of this gene is THEM5.

UniProtKB/Swiss-Prot for THEM4 Gene

  • Has acyl-CoA thioesterase activity towards medium and long-chain (C14 to C18) fatty acyl-CoA substrates, and probably plays an role in mitochondrial fatty acid metabolism. Plays a role in the apoptotic process, possibly via its regulation of AKT1 activity. According to PubMed:11598301, inhibits AKT1 phosphorylation and activity. According to PubMed:17615157, enhances AKT1 activity by favoring its phosphorylation and translocation to plasma membrane.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for THEM4 Gene

Genomics for THEM4 Gene

Regulatory Elements for THEM4 Gene

Promoters for THEM4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around THEM4 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the THEM4 gene promoter:

Genomic Location for THEM4 Gene

Chromosome:
1
Start:
151,870,866 bp from pter
End:
151,909,885 bp from pter
Size:
39,020 bases
Orientation:
Minus strand

Genomic View for THEM4 Gene

Genes around THEM4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
THEM4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for THEM4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for THEM4 Gene

Proteins for THEM4 Gene

  • Protein details for THEM4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5T1C6-THEM4_HUMAN
    Recommended name:
    Acyl-coenzyme A thioesterase THEM4
    Protein Accession:
    Q5T1C6
    Secondary Accessions:
    • B2RBX2
    • Q96KR2

    Protein attributes for THEM4 Gene

    Size:
    240 amino acids
    Molecular mass:
    27130 Da
    Quaternary structure:
    • Homodimer and homotetramer. Interacts with AKT1 in the cytosol.

    Three dimensional structures from OCA and Proteopedia for THEM4 Gene

neXtProt entry for THEM4 Gene

Proteomics data for THEM4 Gene at MOPED

Post-translational modifications for THEM4 Gene

Other Protein References for THEM4 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for THEM4 (CTMP)

No data available for DME Specific Peptides for THEM4 Gene

Domains & Families for THEM4 Gene

Protein Domains for THEM4 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for THEM4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5T1C6

UniProtKB/Swiss-Prot:

THEM4_HUMAN :
  • Belongs to the THEM4/THEM5 thioesterase family.
Family:
  • Belongs to the THEM4/THEM5 thioesterase family.
genes like me logo Genes that share domains with THEM4: view

No data available for Gene Families for THEM4 Gene

Function for THEM4 Gene

Molecular function for THEM4 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=2.4 uM for myristoyl-CoA {ECO:0000269 PubMed:19453107, ECO:0000269 PubMed:22871024}; KM=2.6 uM for palmitoyl-CoA {ECO:0000269 PubMed:19453107, ECO:0000269 PubMed:22871024}; KM=5.2 uM for oleoyl-CoA {ECO:0000269 PubMed:19453107, ECO:0000269 PubMed:22871024};
UniProtKB/Swiss-Prot CatalyticActivity:
Palmitoyl-CoA + H(2)O = CoA + palmitate.
UniProtKB/Swiss-Prot Function:
Has acyl-CoA thioesterase activity towards medium and long-chain (C14 to C18) fatty acyl-CoA substrates, and probably plays an role in mitochondrial fatty acid metabolism. Plays a role in the apoptotic process, possibly via its regulation of AKT1 activity. According to PubMed:11598301, inhibits AKT1 phosphorylation and activity. According to PubMed:17615157, enhances AKT1 activity by favoring its phosphorylation and translocation to plasma membrane.

Enzyme Numbers (IUBMB) for THEM4 Gene

Phenotypes for THEM4 Gene

genes like me logo Genes that share phenotypes with THEM4: view

Animal Models for THEM4 Gene

MGI Knock Outs for THEM4:

Animal Model Products

CRISPR Products

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for THEM4 Gene

Localization for THEM4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for THEM4 Gene

Cell membrane. Cell projection, ruffle membrane. Cytoplasm. Mitochondrion. Mitochondrion inner membrane; Peripheral membrane protein. Mitochondrion intermembrane space. Note=Released from the mitochondria into the cytosol in response to apoptotic stimuli. {ECO:0000269 PubMed:19168129}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for THEM4 Gene COMPARTMENTS Subcellular localization image for THEM4 gene
Compartment Confidence
cytosol 5
mitochondrion 5
plasma membrane 5

Gene Ontology (GO) - Cellular Components for THEM4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IDA 19604401
GO:0005886 plasma membrane TAS --
genes like me logo Genes that share ontologies with THEM4: view

Pathways & Interactions for THEM4 Gene

SuperPathways for THEM4 Gene

Superpath Contained pathways
1 Interleukin-3, 5 and GM-CSF signaling
2 PI3K events in ERBB4 signaling
3 CD28 co-stimulation
4 Immune System
5 Metabolism
genes like me logo Genes that share pathways with THEM4: view

Pathways by source for THEM4 Gene

SIGNOR curated interactions for THEM4 Gene

Inactivates:

Gene Ontology (GO) - Biological Process for THEM4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007173 epidermal growth factor receptor signaling pathway TAS --
GO:0008286 insulin receptor signaling pathway TAS --
GO:0035338 long-chain fatty-acyl-CoA biosynthetic process TAS --
GO:0044255 cellular lipid metabolic process TAS --
GO:0045087 innate immune response TAS --
genes like me logo Genes that share ontologies with THEM4: view

Drugs & Compounds for THEM4 Gene

(2) Drugs for THEM4 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Palmitic Acid Experimental Pharma Full agonist, Agonist 20
Coenzyme A Nutra 0

(2) Additional Compounds for THEM4 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
hexadecanoyl-CoA
Water
  • Dihydrogen oxide
  • Steam
7732-18-5
genes like me logo Genes that share compounds with THEM4: view

Transcripts for THEM4 Gene

Unigene Clusters for THEM4 Gene

Thioesterase superfamily member 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for THEM4 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8
SP1: - - - - -
SP2: - - -
SP3: -
SP4:
SP5: -

Relevant External Links for THEM4 Gene

GeneLoc Exon Structure for
THEM4
ECgene alternative splicing isoforms for
THEM4

Expression for THEM4 Gene

mRNA expression in normal human tissues for THEM4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for THEM4 Gene

This gene is overexpressed in Tlymphocyte (19.2), CD4 Tcells (9.2), Retina (6.9), Heart (6.8), and Pancreatic juice (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for THEM4 Gene



SOURCE GeneReport for Unigene cluster for THEM4 Gene Hs.164070

mRNA Expression by UniProt/SwissProt for THEM4 Gene

Q5T1C6-THEM4_HUMAN
Tissue specificity: Expressed predominantly in skeletal muscle, testis, uterus, brain and kidney. Down-regulated in glioblastoma or glioma compared to non-neoplastic brain due to promoter hypermethylation.
genes like me logo Genes that share expression patterns with THEM4: view

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and Protein tissue co-expression partners for THEM4 Gene

Orthologs for THEM4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for THEM4 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia THEM4 35
  • 83.4 (n)
  • 70.04 (a)
THEM4 36
  • 68 (a)
OneToOne
dog
(Canis familiaris)
Mammalia THEM4 35
  • 80.63 (n)
  • 70.72 (a)
THEM4 36
  • 67 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Them4 35
  • 79.71 (n)
  • 69.57 (a)
Them4 16
Them4 36
  • 69 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia THEM4 35
  • 98.75 (n)
  • 97.08 (a)
THEM4 36
  • 97 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Them4 35
  • 80.14 (n)
  • 70.87 (a)
chicken
(Gallus gallus)
Aves -- 36
  • 46 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 45 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia them4 35
  • 55.15 (n)
  • 53.18 (a)
zebrafish
(Danio rerio)
Actinopterygii zgc:158847 35
  • 55.44 (n)
  • 50.53 (a)
THEM4 36
  • 39 (a)
OneToMany
Species with no ortholog for THEM4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for THEM4 Gene

ENSEMBL:
Gene Tree for THEM4 (if available)
TreeFam:
Gene Tree for THEM4 (if available)

Paralogs for THEM4 Gene

Paralogs for THEM4 Gene

(1) SIMAP similar genes for THEM4 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for THEM4 Gene

genes like me logo Genes that share paralogs with THEM4: view

Variants for THEM4 Gene

Sequence variations from dbSNP and Humsavar for THEM4 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs3748805 - 151,909,409(-) GTGCC(G/T)GCCGC reference, missense, utr-variant-5-prime
rs144257719 - 151,895,181(+) CCTCA(C/G)AAGAA reference, missense, utr-variant-5-prime
rs13320 -- 151,874,041(-) GTACT(A/G)TTGTT utr-variant-3-prime
rs902314 -- 151,892,963(-) acttc(C/T)aggac intron-variant
rs902315 -- 151,892,758(-) TGGTT(C/G)AAATT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for THEM4 Gene

Variant ID Type Subtype PubMed ID
nsv872441 CNV Gain 21882294

Variation tolerance for THEM4 Gene

Residual Variation Intolerance Score: 58.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.99; 20.32% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for THEM4 Gene

HapMap Linkage Disequilibrium report
THEM4
Human Gene Mutation Database (HGMD)
THEM4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for THEM4 Gene

Disorders for THEM4 Gene

MalaCards: The human disease database

(4) MalaCards diseases for THEM4 Gene - From: DISEASES

Disorder Aliases PubMed IDs
anus disease
  • anal disease
myiasis
  • infestation by fly larvae
adamantinous craniopharyngioma
  • adamantinous rathke's pouch tumor
chronic cervicitis
- elite association - COSMIC cancer census association via MalaCards
Search THEM4 in MalaCards View complete list of genes associated with diseases

Relevant External Links for THEM4

Genetic Association Database (GAD)
THEM4
Human Genome Epidemiology (HuGE) Navigator
THEM4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
THEM4
genes like me logo Genes that share disorders with THEM4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for THEM4 Gene

Publications for THEM4 Gene

  1. Carboxyl-terminal modulator protein (CTMP), a negative regulator of PKB/Akt and v-Akt at the plasma membrane. (PMID: 11598301) Maira S.-M. … Hemmings B.A. (Science 2001) 2 3 4 67
  2. Genetic determinants influencing human serum metabolome among African Americans. (PMID: 24625756) Yu B. … Boerwinkle E. (PLoS Genet. 2014) 3
  3. An atlas of genetic influences on human blood metabolites. (PMID: 24816252) Shin S.Y. … Soranzo N. (Nat. Genet. 2014) 3
  4. Carboxyl-terminal modulator protein induces apoptosis by regulating mitochondrial function in lung cancer cells. (PMID: 22200884) Hwang S.K. … Cho M.H. (Int. J. Oncol. 2012) 3
  5. Correlation of structure and function in the human hotdog-fold enzyme hTHEM4. (PMID: 22871024) Zhao H. … Dunaway-Mariano D. (Biochemistry 2012) 3

Products for THEM4 Gene

Sources for THEM4 Gene

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