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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

THEM4 Gene

protein-coding   GIFtS: 58
GCID: GC01M151846

Thioesterase Superfamily Member 4

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Thioesterase Superfamily Member 41 2 3     Carboxyl-Terminal Modulator Protein2 3
CTMP2 3 5     Acyl-Coenzyme A Thioesterase THEM42
C-Terminal Modulator Protein1 2     EC 3.1.2.23
Acyl-CoA Thioesterase THEM42 3     

External Ids:    HGNC: 179471   Entrez Gene: 1171452   Ensembl: ENSG000001594457   OMIM: 6063885   UniProtKB: Q5T1C63   

Export aliases for THEM4 gene to outside databases

Previous GC identifers: GC01M148660 GC01M150112 GC01M123223


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for THEM4 Gene:
Protein kinase B (PKB) is a major downstream target of receptor tyrosine kinases that signal via
phosphatidylinositol 3-kinase. Upon cell stimulation, PKB is translocated to the plasma membrane, where it is
phosphorylated in the C-terminal regulatory domain. The protein encoded by this gene negatively regulates PKB
activity by inhibiting phosphorylation. Transcription of this gene is commonly downregulated in glioblastomas.
(provided by RefSeq, Jul 2008)

GeneCards Summary for THEM4 Gene: 
THEM4 (thioesterase superfamily member 4) is a protein-coding gene. Diseases associated with THEM4 include glioblastoma, and gastric cancer, and among its related super-pathways are Signaling by FGFR and Constitutive PI3K/AKT Signaling in Cancer. GO annotations related to this gene include palmitoyl-CoA hydrolase activity. An important paralog of this gene is THEM5.

UniProtKB/Swiss-Prot: THEM4_HUMAN, Q5T1C6
Function: Has acyl-CoA thioesterase activity towards medium and long-chain (C14 to C18) fatty acyl-CoA substrates,
and probably plays an role in mitochondrial fatty acid metabolism. Plays a role in the apoptotic process,
possibly via its regulation of AKT1 activity. According to PubMed:11598301, inhibits AKT1 phosphorylation and
activity. According to PubMed:17615157, enhances AKT1 activity by favoring its phosphorylation and translocation
to plasma membrane




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.2  NT_004487.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the THEM4 gene promoter:
         Egr-2   S8   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTHEM4 promoter sequence
   Search SABiosciences Chromatin IP Primers for THEM4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat THEM4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q21   Ensembl cytogenetic band:  1q21.3   HGNC cytogenetic band: 1q21.3

THEM4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
THEM4 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M151846:  view genomic region     (about GC identifiers)

Start:
151,843,342 bp from pter      End:
151,882,361 bp from pter
Size:
39,020 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: THEM4_HUMAN, Q5T1C6 (See protein sequence)
Recommended Name: Acyl-coenzyme A thioesterase THEM4 precursor  
Size: 240 amino acids; 27130 Da
Subunit: Homodimer and homotetramer. Interacts with AKT1 in the cytosol
Subcellular location: Cell membrane. Cell projection, ruffle membrane. Cytoplasm. Mitochondrion. Mitochondrion
inner membrane; Peripheral membrane protein. Mitochondrion intermembrane space. Note=Released from the
mitochondria into the cytosol in response to apoptotic stimuli
2 PDB 3D structures from and Proteopedia for THEM4:
4AE8 (3D)        4GAH (3D)    
Secondary accessions: B2RBX2 Q96KR2

Explore the universe of human proteins at neXtProt for THEM4: NX_Q5T1C6

Explore proteomics data for THEM4 at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylated
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q5T1C6

  • THEM4 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    THEM4 Protein Expression
    REFSEQ proteins: NP_444283.2  
    ENSEMBL proteins: 
     ENSP00000357804   ENSP00000431288   ENSP00000433304  
    Reactome Protein details: Q5T1C6
    Human Recombinant Protein Products for THEM4: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for THEM4
    OriGene Protein Over-expression Lysate for THEM4
    OriGene MassSpec for THEM4 
    OriGene Custom Protein Services for THEM4
    GenScript Custom Purified and Recombinant Proteins Services for THEM4
    Novus Biologicals THEM4 Proteins
    Novus Biologicals THEM4 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for THEM4 

    Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion IDA19604401
    GO:0005743mitochondrial inner membrane IEA--
    GO:0005758mitochondrial intermembrane space IEA--
    GO:0005829cytosol TAS--
    GO:0005886plasma membrane TAS--

    THEM4 for ontologies           About GeneDecksing



    THEM4 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of THEM4
    Browse R&D Systems for Antibodies
    Cell Signaling Technology (CST) Antibodies for THEM4  (CTMP)
    OriGene Antibodies for THEM4
    OriGene Custom Antibody Services for THEM4
    GenScript Custom Superior Antibodies Services for THEM4
    Novus Biologicals THEM4 Antibodies
    Abcam antibodies for THEM4
    Cloud-Clone Corp. Antibodies for THEM4 
    ThermoFisher Antibodies for THEM4
    LSBio Antibodies in human, mouse, rat for THEM4 

    Assay Products for THEM4: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for THEM4
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for THEM4
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for THEM4 
    Cloud-Clone Corp. CLIAs for THEM4


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR006683 Thioestr_supf

    Graphical View of Domain Structure for InterPro Entry Q5T1C6

    ProtoNet protein and cluster: Q5T1C6

    UniProtKB/Swiss-Prot: THEM4_HUMAN, Q5T1C6
    Similarity: Belongs to the THEM4/THEM5 thioesterase family


    THEM4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: THEM4_HUMAN, Q5T1C6
    Function: Has acyl-CoA thioesterase activity towards medium and long-chain (C14 to C18) fatty acyl-CoA substrates,
    and probably plays an role in mitochondrial fatty acid metabolism. Plays a role in the apoptotic process,
    possibly via its regulation of AKT1 activity. According to PubMed:11598301, inhibits AKT1 phosphorylation and
    activity. According to PubMed:17615157, enhances AKT1 activity by favoring its phosphorylation and translocation
    to plasma membrane
    Catalytic activity: Palmitoyl-CoA + H(2)O = CoA + palmitate
    Biophysicochemical properties: Kinetic parameters: KM=2.4 uM for myristoyl-CoA; KM=2.6 uM for palmitoyl-CoA;
    KM=5.2 uM for oleoyl-CoA;

         Enzyme Number (IUBMB): EC 3.1.2.21

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016290palmitoyl-CoA hydrolase activity IDA--
         
    THEM4 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for THEM4:
     Decreased viability with pacli 

         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Them4):
     cellular  liver/biliary system  reproductive system 

    THEM4 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for THEM4 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for THEM4

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for THEM4 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for THEM4 

    miRNA
    Products:
        
    miRTarBase miRNAs that target THEM4:
    hsa-mir-30a (MIRT005171)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat THEM4
    4 QIAGEN miScript miRNA Assays for microRNAs that regulate THEM4:
    hsa-miR-4291 hsa-miR-516b hsa-miR-202 hsa-miR-490-3p
    SwitchGear 3'UTR luciferase reporter plasmidTHEM4 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for THEM4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat THEM4

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for THEM4
    Sirion Biotech Customized adenovirus for overexpression of THEM4

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for THEM4 (see all 8)
    OriGene ORF clones in mouse, rat for THEM4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: THEM4 (NM_053055)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for THEM4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat THEM4
    Sirion Biotech Customized lentivirus for stable overexpression of THEM4 
                         Customized lentivirus expression plasmids for stable overexpression of THEM4 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for THEM4
    Search LifeMap BioReagents cell lines for THEM4
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for THEM4


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for THEM4 About   (see all 11)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Signaling by FGFR
    Downstream signaling of activated FGFR0.92
    Downstream signal transduction0.90
    Signaling by FGFR0.92
    Signaling by PDGF0.85
    Signaling by FGFR in disease0.91
    Signaling by EGFR0.84
    DAP12 signaling0.91
    Signaling by EGFR in Cancer0.83
    2PIP3 activates AKT signaling
    GAB1 signalosome0.93
    PI3K events in ERBB2 signaling0.88
    PI3K/AKT activation0.93
    PI3K events in ERBB4 signaling0.88
    PIP3 activates AKT signaling0.88
    Signaling by SCF-KIT0.72
    PI3K/AKT Signaling in Cancer0.88
    Signaling by ERBB40.67
    3IRS-related events
    Insulin receptor signalling cascade0.94
    IGF1R signaling cascade0.92
    IRS-related events0.94
    Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)0.92
    IRS-related events triggered by IGF1R0.93
    PI3K Cascade0.86
    IRS-mediated signalling0.92
    Signaling by Insulin receptor0.79
    4Immune System
    Immune System0.56
    Innate Immune System0.50
    Adaptive Immune System0.56
    5Signaling by the B Cell Receptor (BCR)
    Signaling by the B Cell Receptor (BCR)0.81
    Downstream Signaling Events Of B Cell Receptor (BCR)0.81

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for THEM4
        PI3K / Akt Signaling

    5/40        Reactome Pathways for THEM4 (see all 40)
        Activation of PKB
    Signaling by EGFR in Cancer
    Negative regulation of the PI3K/AKT network
    Downstream signal transduction
    IRS-mediated signalling


    1         Kegg Pathway  (Kegg details for THEM4):
        PI3K-Akt signaling pathway


    THEM4 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for THEM4

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    4 Interacting proteins for THEM4 (Q5T1C62, 3 ENSP000003578044) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    AKT1P317492, 3, ENSP000002702024MINT-8306257 I2D: score=3 STRING: ENSP00000270202
    AKT2ENSP000003758924STRING: ENSP00000375892
    TRIB3ENSP000002172334STRING: ENSP00000217233
    MAP3K8ENSP000002630564STRING: ENSP00000263056
    About this table

    Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006631fatty acid metabolic process IDA--
    GO:0007173epidermal growth factor receptor signaling pathway TAS--
    GO:0008286insulin receptor signaling pathway TAS--
    GO:0008543fibroblast growth factor receptor signaling pathway TAS--
    GO:0038095Fc-epsilon receptor signaling pathway TAS--

    THEM4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for THEM4

    Search CenterWatch for drugs/clinical trials and news about THEM4

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for THEM4 gene (2 alternative transcripts): 
    NM_053055.4  NM_176853.2  

    Unigene Cluster for THEM4:

    Thioesterase superfamily member 4
    Hs.164070  [show with all ESTs]
    Unigene Representative Sequence: NM_053055
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000368814(uc001ezj.2 uc001ezk.2) ENST00000471464 ENST00000483207
    ENST00000477437 ENST00000489410
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat THEM4
    4 QIAGEN miScript miRNA Assays for microRNAs that regulate THEM4:
    hsa-miR-4291 hsa-miR-516b hsa-miR-202 hsa-miR-490-3p
    SwitchGear 3'UTR luciferase reporter plasmidTHEM4 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for THEM4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat THEM4
    Clone
    Products:
         
    OriGene clones in human, mouse for THEM4 (see all 8)
    OriGene ORF clones in mouse, rat for THEM4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: THEM4 (NM_053055)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for THEM4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat THEM4
    Sirion Biotech Customized lentivirus for stable overexpression of THEM4 
                         Customized lentivirus expression plasmids for stable overexpression of THEM4 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for THEM4
    OriGene qSTAR qPCR primer pairs in human, mouse for THEM4
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat THEM4
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat THEM4
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat THEM4

    Additional mRNA sequence: 

    AF075119.1 AJ313515.1 AK024219.1 AK096211.1 AK130716.1 AK289494.1 AK314852.1 BC017339.2 
    BC065277.1 

    14 DOTS entries:

    DT.100785377  DT.95073221  DT.101958305  DT.95073218  DT.40285681  DT.109450  DT.121382313  DT.95093278 
    DT.100785376  DT.100785380  DT.75153948  DT.121055363  DT.75189924  DT.97773650 

    24/109 AceView cDNA sequences (see all 109):

    AW014523 AI702843 NM_176853 BG468483 AW074631 AI097570 BM973487 BX390253 
    CB986058 BE067599 BX355566 BG386295 CB133281 BU183570 R78215 CB111766 
    AI887946 BG762885 AU123291 AW300402 BF196099 BM715605 CK824554 AI810952 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for THEM4    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8
    SP1:                    -           -     -     -     -                                       
    SP2:                    -           -                 -                                       
    SP3:                                -                                                         
    SP4:                                                                                          
    SP5:                    -                                                                     


    ECgene alternative splicing isoforms for THEM4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    THEM4 expression in normal human tissues (normalized intensities)      THEM4 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AATCTTTTTT
    THEM4 Expression
    About this image


    THEM4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/3 selected tissues (see all 3) fully expand
     
     Blood (Cardiovascular System)    fully expand to see all 3 entries
             T Helper Cells Thymus
             cd3+ t cells   
     
     Thymus (Hematopoietic System)
             T Helper Cells Thymus
     
     Spinal Cord (Nervous System)
             motor neurons   

    See THEM4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for THEM4

    SOURCE GeneReport for Unigene cluster: Hs.164070

    UniProtKB/Swiss-Prot: THEM4_HUMAN, Q5T1C6
    Tissue specificity: Expressed predominantly in skeletal muscle, testis, uterus, brain and kidney. Down-regulated
    in glioblastoma or glioma compared to non-neoplastic brain due to promoter hypermethylation

        SABiosciences Custom PCR Arrays for THEM4
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for THEM4
    OriGene qSTAR qPCR primer pairs in human, mouse for THEM4
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat THEM4
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat THEM4
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat THEM4
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for THEM4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for THEM4 gene from 4/8 species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Them41 , 5 thioesterase superfamily member 41, 5 79.71(n)1
    69.57(a)1
      3 (40.51 cM)5
    757781  NM_029431.11  NP_083707.11 
     943100895 
    chicken
    (Gallus gallus)
    Aves LOC1008582231 thioesterase superfamily member 4-like 51.07(n)
    46.2(a)
      100858223  XM_003642701.1  XP_003642749.1 
    lizard
    (Anolis carolinensis)
    Reptilia THEM56
    Uncharacterized protein
    46(a)
    1 → many
    GL344049.1(19514-22505)
    zebrafish
    (Danio rerio)
    Actinopterygii zgc:1588471 zgc:158847 55.44(n)
    50.53(a)
      791152  NM_001080634.1  NP_001074103.1 


    ENSEMBL Gene Tree for THEM4 (if available)
    TreeFam Gene Tree for THEM4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for THEM4 gene
    THEM52  
    1 SIMAP similar gene for THEM4 using alignment to 3 protein entries:     THEM4_HUMAN (see all proteins):
    THEM5

    THEM4 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for THEM4
    PGOHUM00000239704 PGOHUM00000246791


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/754 SNPs in THEM4 are shown (see all 754)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1813569531,2
    --151842922(+) AAGGAA/GTAAAC 1 -- ds50010--------
    rs730096481,2
    C,F--151842950(+) ACTGGC/TCAGAG 1 -- ds50012Minor allele frequency- T:0.04WA 120
    rs1499744591,2
    --151842984(+) CAAGTA/GAAATT 1 -- ds50010--------
    rs168336101,2
    C,F,H--151843044(+) AAAGAT/CTGCCT 1 -- ds500113Minor allele frequency- C:0.07NA NS EA WA 1354
    rs168336121,2
    C,F--151843188(+) AGAAGG/ATAATG 1 -- ds50015Minor allele frequency- A:0.01NA 146
    rs1851352321,2
    --151843413(+) CTCACA/GGCCTA 1 -- ut310--------
    rs1489101081,2
    --151843436(+) CTGATA/GGTTTA 1 -- ut310--------
    rs1898934541,2
    --151843441(+) AGTTTA/CAAGAT 1 -- ut310--------
    rs1470079221,2
    --151843743(+) TTGCAC/TTGAGC 1 -- ut310--------
    rs113043991,2
    C--151843802(+) TCTTG-/A/AA  
            
    AAAAA
    2 -- ut311CSA 2

    HapMap Linkage Disequilibrium report for THEM4 (151843342 - 151882361 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for THEM4:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv872441CNV Gain21882294

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 606388    OMIM disorders: --

    3 diseases for THEM4:    About MalaCards
    glioblastoma    gastric cancer    lung cancer


    THEM4 for disorders           About GeneDecksing

    Genetic Association Database (GAD): THEM4
    Human Genome Epidemiology (HuGE) Navigator: THEM4 (1 document)

    Export disorders for THEM4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for THEM4 gene, integrated from 9 sources (see all 22):
    (articles sorted by number of sources associating them with THEM4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Carboxyl-terminal modulator protein (CTMP), a negative regulator of PKB/Akt and v-Akt at the plasma membrane. (PubMed id 11598301)1, 2, 3 Maira S.-M....Hemmings B.A. (2001)
    2. Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (2010)
    3. Heat shock protein 70-mediated sensitization of cells to apoptosis by Carboxyl-Terminal Modulator Protein. (PubMed id 19604401)1, 2 Piao L....Park J. (2009)
    4. Carboxy-Terminal Modulator Protein (CTMP) is a mitochondrial protein that sensitizes cells to apoptosis. (PubMed id 19168129)1, 2 Parcellier A....Hemmings B.A. (2009)
    5. Carboxy-terminal modulator protein induces Akt phosphorylation and activation, thereby enhancing antiapoptotic, glycogen synthetic, and glucose uptake pathways. (PubMed id 17615157)1, 2 Ono H.... Asano T. (2007)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    7. Hypermethylation and transcriptional downregulation of the carboxyl- terminal modulator protein gene in glioblastomas. (PubMed id 15026474)1, 2 Knobbe C.B.... Reifenberger G. (2004)
    8. Correlation of structure and function in the human hotdog-fold enzyme hTHEM4. (PubMed id 22871024)2 Zhao H.... Dunaway-Mariano D. (2012)
    9. Carboxyl-terminal modulator protein induces apoptosis by regulating mitochondrial function in lung cancer cells. (PubMed id 22200884)1 Hwang S.K....Cho M.H. (2012)
    10. Acyl coenzyme A thioesterase Them5/Acot15 is involved in cardiolipin remodeling and fatty liver development. (PubMed id 22586271)2 Zhuravleva E.... Hemmings B.A. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 117145 HGNC: 17947 AceView: CTMP Ensembl:ENSG00000159445 euGenes: HUgn117145
    ECgene: THEM4 Kegg: 117145 H-InvDB: THEM4

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for THEM4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for THEM4 gene:
    Search GeneIP for patents involving THEM4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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