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Aliases for THEGL Gene

Aliases for THEGL Gene

  • Theg Spermatid Protein-Like 2 3 5
  • Theg Spermatid-Like Protein 4

External Ids for THEGL Gene

Previous GeneCards Identifiers for THEGL Gene

  • GC04P057398

Summaries for THEGL Gene

GeneCards Summary for THEGL Gene

THEGL (Theg Spermatid Protein-Like) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for THEGL Gene

Genomics for THEGL Gene

Regulatory Elements for THEGL Gene

Enhancers for THEGL Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04F056530 0.9 ENCODE 17.6 +0.4 395 0.8 TBP CBX3 CREB3L1 BMI1 SCRT2 ZHX1 SP3 SMAD5 REST SP1 SRP72 ARL9 THEGL ENSG00000251799 SPINK2 GLDCP1
GH04F056544 1.3 Ensembl ENCODE 0.4 +14.2 14220 1.2 CREB3L1 ARID4B DMAP1 ZNF2 ZNF143 ZNF207 SP3 MXD4 REST SMARCB1 SPINK2 ENSG00000251799 AASDH ARL9 THEGL GLDCP1
GH04F056531 0.4 ENCODE 0.8 +1.0 1015 0.2 MGA ARL9 SRP72 ENSG00000251799 SPINK2 THEGL GLDCP1
GH04F056540 0.5 Ensembl 0.4 +10.3 10326 0.2 ATF3 ZNF512 ATF2 ARL9 SRP72 PAICS PPAT SPINK2 ENSG00000251799 HOPX AASDH THEGL GLDCP1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around THEGL on UCSC Golden Path with GeneCards custom track

Promoters for THEGL Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001431445 26 1200 TBP CBX3 CREB3L1 BMI1 SCRT2 ZHX1 SP3 SMAD5 REST SP1

Genomic Location for THEGL Gene

Chromosome:
4
Start:
56,530,575 bp from pter
End:
56,641,550 bp from pter
Size:
110,976 bases
Orientation:
Plus strand

Genomic View for THEGL Gene

Genes around THEGL on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
THEGL Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for THEGL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for THEGL Gene

Proteins for THEGL Gene

  • Protein details for THEGL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0DJG4-THEGL_HUMAN
    Recommended name:
    Testicular haploid expressed gene protein-like
    Protein Accession:
    P0DJG4

    Protein attributes for THEGL Gene

    Size:
    465 amino acids
    Molecular mass:
    53028 Da
    Quaternary structure:
    No Data Available

neXtProt entry for THEGL Gene

Post-translational modifications for THEGL Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for THEGL Gene

No data available for DME Specific Peptides for THEGL Gene

Domains & Families for THEGL Gene

Protein Domains for THEGL Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

P0DJG4

UniProtKB/Swiss-Prot:

THEGL_HUMAN :
  • Contains 8 THEG repeats.
Similarity:
  • Contains 8 THEG repeats.
genes like me logo Genes that share domains with THEGL: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for THEGL Gene

Function for THEGL Gene

Phenotypes for THEGL Gene

genes like me logo Genes that share phenotypes with THEGL: view

Animal Models for THEGL Gene

MGI Knock Outs for THEGL:

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for THEGL Gene

Localization for THEGL Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for THEGL Gene

Pathways & Interactions for THEGL Gene

SuperPathways for THEGL Gene

No Data Available

Interacting Proteins for THEGL Gene

Selected Interacting proteins: P0DJG4-THEGL_HUMAN for THEGL Gene via IID

Symbol External ID(s) Details
MAPK3

Gene Ontology (GO) - Biological Process for THEGL Gene

None

No data available for Pathways by source and SIGNOR curated interactions for THEGL Gene

Transcripts for THEGL Gene

mRNA/cDNA for THEGL Gene

(6) REFSEQ mRNAs :
(0) Additional mRNA sequences :
-
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for THEGL Gene

Theg spermatid protein-like:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for THEGL Gene

No ASD Table

Relevant External Links for THEGL Gene

GeneLoc Exon Structure for
THEGL
ECgene alternative splicing isoforms for
THEGL

Expression for THEGL Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for THEGL Gene

mRNA differential expression in normal tissues according to GTEx for THEGL Gene

This gene is overexpressed in Testis (x29.2).

Protein differential expression in normal tissues from HIPED for THEGL Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (48.6) and Cerebrospinal fluid (14.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for THEGL Gene



Protein tissue co-expression partners for THEGL Gene

NURSA nuclear receptor signaling pathways regulating expression of THEGL Gene:

THEGL

SOURCE GeneReport for Unigene cluster for THEGL Gene:

Hs.573073
genes like me logo Genes that share expression patterns with THEGL: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for THEGL Gene

Orthologs for THEGL Gene

This gene was present in the common ancestor of chordates.

Orthologs for THEGL Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia THEGL 34
  • 98.91 (n)
cow
(Bos Taurus)
Mammalia THEGL 34
  • 78.54 (n)
dog
(Canis familiaris)
Mammalia THEGL 35 34
  • 77.88 (n)
OneToOne
mouse
(Mus musculus)
Mammalia 1700023E05Rik 34 35
  • 71.51 (n)
Thegl 16
rat
(Rattus norvegicus)
Mammalia LOC498350 34
  • 70.4 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia THEGL 35
  • 39 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia THEGL 35
  • 37 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 36 (a)
OneToOne
Species where no ortholog for THEGL was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for THEGL Gene

ENSEMBL:
Gene Tree for THEGL (if available)
TreeFam:
Gene Tree for THEGL (if available)

Paralogs for THEGL Gene

No data available for Paralogs for THEGL Gene

Variants for THEGL Gene

Sequence variations from dbSNP and Humsavar for THEGL Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs10000144 -- 56,543,897(+) GAGAg(A/T)gtgtg intron-variant
rs10000346 -- 56,583,157(+) taatc(C/T)gagct intron-variant
rs10004985 -- 56,621,470(+) CAAAC(A/G)TCTCA intron-variant, utr-variant-3-prime
rs10006347 -- 56,560,673(+) tcctt(C/T)tgcct intron-variant
rs10006458 -- 56,590,882(+) TTTAA(C/T)TAGTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for THEGL Gene

Variant ID Type Subtype PubMed ID
nsv964047 CNV duplication 23825009
nsv829942 CNV gain 17160897
nsv829941 CNV loss 17160897
esv3600579 CNV loss 21293372
esv3600578 CNV loss 21293372
dgv5213n100 CNV gain 25217958

Variation tolerance for THEGL Gene

Gene Damage Index Score: 6.67; 78.48% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for THEGL Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
THEGL

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for THEGL Gene

Disorders for THEGL Gene

Relevant External Links for THEGL

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
THEGL

No disorders were found for THEGL Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for THEGL Gene

Publications for THEGL Gene

  1. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 4 64
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64

Products for THEGL Gene

Sources for THEGL Gene

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