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Aliases for THEG Gene

Aliases for THEG Gene

  • Theg Spermatid Protein 2 3 5
  • Cancer/Testis Antigen 56 2 3 4
  • CT56 3 4
  • Testicular Haploid Expressed Gene Protein 3
  • Theg Homolog (Mouse) 2
  • Testis-Specific 3
  • Theg Homolog 3
  • THEG1 3

External Ids for THEG Gene

Previous GeneCards Identifiers for THEG Gene

  • GC19M000302
  • GC19M000313
  • GC19M000131

Summaries for THEG Gene

Entrez Gene Summary for THEG Gene

  • This gene is specifically expressed in the nucleus of haploid male germ cells. The orthologous gene in mice encodes a protein that may play a role in protein assembly through interactions with T-complex protein 1 subunit epsilon. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]

GeneCards Summary for THEG Gene

THEG (Theg Spermatid Protein) is a Protein Coding gene.

UniProtKB/Swiss-Prot for THEG Gene

  • May be involved (but not essential) in spermatogenesis.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for THEG Gene

Genomics for THEG Gene

Regulatory Elements for THEG Gene

Enhancers for THEG Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F000341 1.3 FANTOM5 ENCODE 11.5 +33.0 33019 3.5 CREB3L1 SIN3A ZNF48 KLF13 ZNF263 SP5 NFYC MXD4 KAT8 MBD2 THEG MIER2 GC19M000319
GH19F000412 0.7 ENCODE 11.6 -35.7 -35718 0.7 CTCF ZNF263 KLF1 MAZ SP2 ZIC2 ZFP69B ZNF692 POLR2A GLIS1 THEG PIR44542 PIR54633
GH19F000417 0.4 ENCODE 11.6 -41.1 -41062 1.0 RFX1 KDM1A THEG SHC2 C2CD4C LOC101928450 PIR44542 PIR54633
GH19F000603 1.5 FANTOM5 Ensembl ENCODE 1.5 -228.4 -228354 2.6 HDGF ATF1 PKNOX1 ARNT CREB3L1 GATA2 ZNF143 NCOA1 MEF2D SMARCA4 FSTL3 HCN2 THEG GC19P000606 LOC100420586
GH19F000371 0.6 ENCODE 0.8 +4.4 4433 1.6 CTCF RAD51 BHLHE40 USF2 ELF1 FOXP2 REST GC19P000369 THEG
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around THEG on UCSC Golden Path with GeneCards custom track

Genomic Location for THEG Gene

Chromosome:
19
Start:
361,747 bp from pter
End:
376,703 bp from pter
Size:
14,957 bases
Orientation:
Minus strand

Genomic View for THEG Gene

Genes around THEG on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
THEG Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for THEG Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for THEG Gene

Proteins for THEG Gene

  • Protein details for THEG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P2T0-THEG_HUMAN
    Recommended name:
    Testicular haploid expressed gene protein
    Protein Accession:
    Q9P2T0
    Secondary Accessions:
    • A6NMJ8

    Protein attributes for THEG Gene

    Size:
    379 amino acids
    Molecular mass:
    43444 Da
    Quaternary structure:
    • Interacts with CCT5.

    Alternative splice isoforms for THEG Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for THEG Gene

Post-translational modifications for THEG Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for THEG Gene

No data available for DME Specific Peptides for THEG Gene

Domains & Families for THEG Gene

Protein Domains for THEG Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for THEG Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9P2T0

UniProtKB/Swiss-Prot:

THEG_HUMAN :
  • Contains 6 THEG repeats.
Similarity:
  • Contains 6 THEG repeats.
genes like me logo Genes that share domains with THEG: view

No data available for Gene Families for THEG Gene

Function for THEG Gene

Molecular function for THEG Gene

UniProtKB/Swiss-Prot Function:
May be involved (but not essential) in spermatogenesis.

Gene Ontology (GO) - Molecular Function for THEG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with THEG: view
genes like me logo Genes that share phenotypes with THEG: view

Animal Models for THEG Gene

MGI Knock Outs for THEG:

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for THEG Gene

Localization for THEG Gene

Subcellular locations from UniProtKB/Swiss-Prot for THEG Gene

Nucleus. Note=Localized predominantly in the nucleus of haploid round spermatid. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for THEG gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for THEG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with THEG: view

Pathways & Interactions for THEG Gene

No Data Available

Gene Ontology (GO) - Biological Process for THEG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organism development IEA --
GO:0007283 spermatogenesis IEA,TAS --
GO:0030154 cell differentiation IEA --
GO:0051131 chaperone-mediated protein complex assembly TAS 10747865
genes like me logo Genes that share ontologies with THEG: view

No data available for Pathways by source and SIGNOR curated interactions for THEG Gene

Transcripts for THEG Gene

mRNA/cDNA for THEG Gene

Unigene Clusters for THEG Gene

Theg spermatid protein:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for THEG Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b
SP1: - -
SP2:
SP3: - - - - -

Relevant External Links for THEG Gene

GeneLoc Exon Structure for
THEG
ECgene alternative splicing isoforms for
THEG

Expression for THEG Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for THEG Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for THEG Gene

This gene is overexpressed in Testis (x46.5).

Protein differential expression in normal tissues from HIPED for THEG Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (67.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for THEG Gene



Protein tissue co-expression partners for THEG Gene

NURSA nuclear receptor signaling pathways regulating expression of THEG Gene:

THEG

SOURCE GeneReport for Unigene cluster for THEG Gene:

Hs.250002

mRNA Expression by UniProt/SwissProt for THEG Gene:

Q9P2T0-THEG_HUMAN
Tissue specificity: Testis specific.
genes like me logo Genes that share expression patterns with THEG: view

Primer Products

Orthologs for THEG Gene

This gene was present in the common ancestor of chordates.

Orthologs for THEG Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia THEG 34 35
  • 99.21 (n)
cow
(Bos Taurus)
Mammalia THEG 34 35
  • 77.4 (n)
dog
(Canis familiaris)
Mammalia THEG 34 35
  • 76.54 (n)
mouse
(Mus musculus)
Mammalia Theg 34 16 35
  • 76.46 (n)
rat
(Rattus norvegicus)
Mammalia Theg 34
  • 69.7 (n)
oppossum
(Monodelphis domestica)
Mammalia THEG 35
  • 44 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia THEG 35
  • 34 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii THEG 35
  • 28 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 30 (a)
OneToOne
Species where no ortholog for THEG was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for THEG Gene

ENSEMBL:
Gene Tree for THEG (if available)
TreeFam:
Gene Tree for THEG (if available)

Paralogs for THEG Gene

No data available for Paralogs for THEG Gene

Variants for THEG Gene

Sequence variations from dbSNP and Humsavar for THEG Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1020384 -- 366,804(+) CAACA(C/T)CCATT intron-variant
rs10401538 -- 370,591(+) gtgat(A/C)caccc intron-variant
rs10409341 -- 376,031(+) TGTGG(C/T)GGCCG upstream-variant-2KB, reference, synonymous-codon
rs10410345 -- 374,492(+) GAAGC(C/G)TGGGT intron-variant
rs10413577 -- 371,129(+) CAAAC(A/G)CAAAG intron-variant, downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for THEG Gene

Variant ID Type Subtype PubMed ID
nsv9660 CNV loss 18304495
nsv953938 CNV deletion 24416366
nsv833702 CNV loss 17160897
nsv577980 CNV gain 21841781
nsv577978 CNV gain 21841781
nsv522660 CNV loss 19592680
nsv509711 CNV insertion 20534489
nsv428360 CNV gain 18775914
nsv1146930 CNV deletion 26484159
nsv1134737 CNV deletion 24896259
nsv1127641 CNV deletion 24896259
nsv1065558 CNV gain 25217958
esv3643348 CNV loss 21293372
esv3583200 CNV loss 25503493
esv2758742 CNV gain 17122850
esv2669963 CNV deletion 23128226
esv2422333 CNV duplication 17116639
esv1010364 CNV insertion 20482838
dgv3420n100 CNV gain 25217958

Variation tolerance for THEG Gene

Residual Variation Intolerance Score: 98.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.16; 80.76% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for THEG Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
THEG

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for THEG Gene

Disorders for THEG Gene

Relevant External Links for THEG

Genetic Association Database (GAD)
THEG
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
THEG

No disorders were found for THEG Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for THEG Gene

Publications for THEG Gene

  1. Alternative splicing, chromosome assignment and subcellular localization of the testicular haploid expressed gene (THEG). (PMID: 11173852) Mannan A. … Burfeind P. (Cytogenet. Cell Genet. 2000) 2 3 4 64
  2. Insertional mutation of the murine kisimo locus caused a defect in spermatogenesis. (PMID: 10747865) Yanaka N. … Mori C. (J. Biol. Chem. 2000) 3 4 64
  3. Next-generation sequencing to generate interactome datasets. (PMID: 21516116) Yu H. … Vidal M. (Nat. Methods 2011) 3 64
  4. An empirical framework for binary interactome mapping. (PMID: 19060904) Venkatesan K. … Vidal M. (Nat. Methods 2009) 3 64
  5. Towards a proteome-scale map of the human protein-protein interaction network. (PMID: 16189514) Rual J.F. … Vidal M. (Nature 2005) 3 64

Products for THEG Gene

Sources for THEG Gene

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