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Aliases for THEG Gene

Aliases for THEG Gene

  • Theg Spermatid Protein 2 3
  • Cancer/Testis Antigen 56 2 3 4
  • CT56 3 4
  • Testicular Haploid Expressed Gene Protein 3
  • Theg Homolog (Mouse) 2
  • Testis-Specific 3
  • Theg Homolog 3
  • THEG1 3

External Ids for THEG Gene

Previous GeneCards Identifiers for THEG Gene

  • GC19M000302
  • GC19M000313
  • GC19M000131

Summaries for THEG Gene

Entrez Gene Summary for THEG Gene

  • This gene is specifically expressed in the nucleus of haploid male germ cells. The orthologous gene in mice encodes a protein that may play a role in protein assembly through interactions with T-complex protein 1 subunit epsilon. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]

GeneCards Summary for THEG Gene

THEG (Theg Spermatid Protein) is a Protein Coding gene.

UniProtKB/Swiss-Prot for THEG Gene

  • May be involved (but not essential) in spermatogenesis.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for THEG Gene

Genomics for THEG Gene

Regulatory Elements for THEG Gene

Genomic Location for THEG Gene

361,750 bp from pter
376,688 bp from pter
14,939 bases
Minus strand

Genomic View for THEG Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for THEG Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for THEG Gene

Proteins for THEG Gene

  • Protein details for THEG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Testicular haploid expressed gene protein
    Protein Accession:
    Secondary Accessions:
    • A6NMJ8

    Protein attributes for THEG Gene

    379 amino acids
    Molecular mass:
    43444 Da
    Quaternary structure:
    • Interacts with CCT5.

    Alternative splice isoforms for THEG Gene


neXtProt entry for THEG Gene

Proteomics data for THEG Gene at MOPED

Post-translational modifications for THEG Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for THEG Gene

No data available for DME Specific Peptides for THEG Gene

Domains for THEG Gene

Protein Domains for THEG Gene


Suggested Antigen Peptide Sequences for THEG Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 6 THEG repeats.
  • Contains 6 THEG repeats.
genes like me logo Genes that share domains with THEG: view

No data available for Gene Families for THEG Gene

Function for THEG Gene

Molecular function for THEG Gene

UniProtKB/Swiss-Prot Function:
May be involved (but not essential) in spermatogenesis.

Gene Ontology (GO) - Molecular Function for THEG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with THEG: view
genes like me logo Genes that share phenotypes with THEG: view

Animal Models for THEG Gene

MGI Knock Outs for THEG:

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for THEG

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targets and HOMER Transcription for THEG Gene

Localization for THEG Gene

Subcellular locations from UniProtKB/Swiss-Prot for THEG Gene

Nucleus. Note=Localized predominantly in the nucleus of haploid round spermatid. {ECO:0000250}.

Subcellular locations from

Jensen Localization Image for THEG Gene COMPARTMENTS Subcellular localization image for THEG gene
Compartment Confidence
nucleus 3
chloroplast 1
golgi apparatus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for THEG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with THEG: view

Pathways for THEG Gene

SuperPathways for THEG Gene

No Data Available

Interacting Proteins for THEG Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
Selected Interacting proteins: Q9P2T0-THEG_HUMAN ENSP00000340088 for THEG Gene via MINT STRING UniProtKB I2D

Gene Ontology (GO) - Biological Process for THEG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organismal development IEA --
GO:0007283 spermatogenesis IEA --
GO:0030154 cell differentiation IEA --
GO:0051131 chaperone-mediated protein complex assembly TAS 10747865
genes like me logo Genes that share ontologies with THEG: view

No data available for Pathways by source for THEG Gene

Transcripts for THEG Gene

mRNA/cDNA for THEG Gene

(6) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(13) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for THEG Gene

Theg spermatid protein:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for THEG

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for THEG Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b
SP1: - -
SP3: - - - - -

Relevant External Links for THEG Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for THEG Gene

mRNA expression in normal human tissues for THEG Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for THEG Gene

This gene is overexpressed in Testis (46.5).

Protein differential expression in normal tissues for THEG Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (67.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for THEG Gene

SOURCE GeneReport for Unigene cluster for THEG Gene Hs.250002

mRNA Expression by UniProt/SwissProt for THEG Gene

Tissue specificity: Testis specific.
genes like me logo Genes that share expressions with THEG: view

Expression partners for THEG Gene

* - Elite partner

Primer Products

In Situ Assay Products

Orthologs for THEG Gene

This gene was present in the common ancestor of chordates.

Orthologs for THEG Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia THEG 35
  • 77.4 (n)
  • 71.23 (a)
  • 67 (a)
(Canis familiaris)
Mammalia THEG 35
  • 76.54 (n)
  • 65.92 (a)
  • 66 (a)
(Mus musculus)
Mammalia Theg 35
  • 76.46 (n)
  • 70.63 (a)
Theg 16
Theg 36
  • 59 (a)
(Pan troglodytes)
Mammalia THEG 35
  • 99.21 (n)
  • 98.15 (a)
  • 98 (a)
(Rattus norvegicus)
Mammalia Theg 35
  • 69.7 (n)
  • 62.94 (a)
(Monodelphis domestica)
Mammalia THEG 36
  • 44 (a)
(Ornithorhynchus anatinus)
Mammalia THEG 36
  • 34 (a)
(Danio rerio)
Actinopterygii THEG 36
  • 28 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 30 (a)
Species with no ortholog for THEG:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for THEG Gene

Gene Tree for THEG (if available)
Gene Tree for THEG (if available)

Paralogs for THEG Gene

No data available for Paralogs for THEG Gene

Variants for THEG Gene

Sequence variations from dbSNP and Humsavar for THEG Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs583307 -- 366,846(+) TCTGG(C/T)TCCTG intron-variant
rs585487 -- 367,313(+) ACACT(A/G)AAAGA intron-variant
rs597763 -- 367,726(+) TGACC(C/G)GAGGA intron-variant
rs608177 -- 369,604(+) TTTCA(G/T)GCACA intron-variant
rs617479 -- 364,502(+) acagc(A/G)agacc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for THEG Gene

Variant ID Type Subtype PubMed ID
dgv1054e1 CNV Complex 17122850
nsv428360 CNV Gain 18775914
nsv833702 CNV Loss 17160897
esv2422333 CNV Duplication 17116639
dgv3496n71 CNV Loss 21882294
dgv3497n71 CNV Loss 21882294
nsv910077 CNV Loss 21882294
dgv3498n71 CNV Loss 21882294
nsv910083 CNV Loss 21882294
nsv509711 CNV Insertion 20534489
dgv3499n71 CNV Loss 21882294
nsv9660 CNV Loss 18304495
nsv522660 CNV Loss 19592680
esv2669963 CNV Deletion 23128226
nsv910085 CNV Loss 21882294
dgv3500n71 CNV Loss 21882294
esv1010364 CNV Insertion 20482838

Relevant External Links for THEG Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for THEG Gene

Disorders for THEG Gene

Relevant External Links for THEG

Genetic Association Database (GAD)

No disorders were found for THEG Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for THEG Gene

Publications for THEG Gene

  1. Alternative splicing, chromosome assignment and subcellular localization of the testicular haploid expressed gene (THEG). (PMID: 11173852) Mannan A. … Burfeind P. (Cytogenet. Cell Genet. 2000) 2 3 4
  2. Insertional mutation of the murine kisimo locus caused a defect in spermatogenesis. (PMID: 10747865) Yanaka N. … Mori C. (J. Biol. Chem. 2000) 3 4
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  4. Male mice lacking the Theg (testicular haploid expressed gene) protein undergo normal spermatogenesis and are fertile. (PMID: 12748127) Mannan A.U. … Engel W. (Biol. Reprod. 2003) 3
  5. Towards a proteome-scale map of the human protein-protein interaction network. (PMID: 16189514) Rual J.F. … Vidal M. (Nature 2005) 3

Products for THEG Gene

Sources for THEG Gene

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