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Aliases for THEG Gene

Aliases for THEG Gene

  • Theg Spermatid Protein 2 3 5
  • Cancer/Testis Antigen 56 2 3 4
  • CT56 3 4
  • Testicular Haploid Expressed Gene Protein 3
  • Theg Homolog (Mouse) 2
  • Testis-Specific 3
  • Theg Homolog 3
  • THEG1 3

External Ids for THEG Gene

Previous GeneCards Identifiers for THEG Gene

  • GC19M000302
  • GC19M000313
  • GC19M000131

Summaries for THEG Gene

Entrez Gene Summary for THEG Gene

  • This gene is specifically expressed in the nucleus of haploid male germ cells. The orthologous gene in mice encodes a protein that may play a role in protein assembly through interactions with T-complex protein 1 subunit epsilon. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]

GeneCards Summary for THEG Gene

THEG (Theg Spermatid Protein) is a Protein Coding gene.

UniProtKB/Swiss-Prot for THEG Gene

  • May be involved (but not essential) in spermatogenesis.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for THEG Gene

Genomics for THEG Gene

Regulatory Elements for THEG Gene

Enhancers for THEG Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19G000341 1.3 FANTOM5 ENCODE 11.5 +33.0 33019 3.5 CREB3L1 SIN3A ZNF48 FOS KLF13 KDM4B ZNF263 SP5 NFYC MXD4 THEG MIER2 GC19M000319
GH19G000412 0.7 ENCODE 11.6 -35.7 -35718 0.7 CTCF KLF1 ZIC2 ZBTB48 POLR2A PATZ1 KLF8 ZNF263 MAZ SP2 THEG PIR44542 PIR54633
GH19G000281 0.6 dbSUPER 11.4 +95.2 95247 0.8 OSR2 ZNF263 NR2C1 NFXL1 ZIC2 EZH2 THEG PLPP2 C2CD4C LILRA3
GH19G000417 0.5 ENCODE 11.6 -41.1 -41062 1.0 RFX1 KDM1A RBBP5 THEG SHC2 C2CD4C LOC101928450 PIR44542 PIR54633
GH19G000282 0.5 dbSUPER 11.4 +94.4 94439 0.5 CTCF ADNP ZMYM3 KDM1A PLPP2 THEG C2CD4C LILRA3
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around THEG on UCSC Golden Path with GeneCards custom track

Genomic Location for THEG Gene

361,747 bp from pter
376,703 bp from pter
14,957 bases
Minus strand

Genomic View for THEG Gene

Genes around THEG on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
THEG Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for THEG Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for THEG Gene

Proteins for THEG Gene

  • Protein details for THEG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Testicular haploid expressed gene protein
    Protein Accession:
    Secondary Accessions:
    • A6NMJ8

    Protein attributes for THEG Gene

    379 amino acids
    Molecular mass:
    43444 Da
    Quaternary structure:
    • Interacts with CCT5.

    Alternative splice isoforms for THEG Gene


neXtProt entry for THEG Gene

Post-translational modifications for THEG Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for THEG Gene

No data available for DME Specific Peptides for THEG Gene

Domains & Families for THEG Gene

Protein Domains for THEG Gene


Suggested Antigen Peptide Sequences for THEG Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with THEG: view

No data available for Gene Families and UniProtKB/Swiss-Prot for THEG Gene

Function for THEG Gene

Molecular function for THEG Gene

UniProtKB/Swiss-Prot Function:
May be involved (but not essential) in spermatogenesis.

Gene Ontology (GO) - Molecular Function for THEG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with THEG: view
genes like me logo Genes that share phenotypes with THEG: view

Animal Models for THEG Gene

MGI Knock Outs for THEG:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for THEG Gene

Localization for THEG Gene

Subcellular locations from UniProtKB/Swiss-Prot for THEG Gene

Nucleus. Note=Localized predominantly in the nucleus of haploid round spermatid. {ECO:0000250}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for THEG gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for THEG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with THEG: view

Pathways & Interactions for THEG Gene

No Data Available

Interacting Proteins for THEG Gene

Gene Ontology (GO) - Biological Process for THEG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organism development IEA --
GO:0007283 spermatogenesis TAS,IEA --
GO:0030154 cell differentiation IEA --
GO:0051131 chaperone-mediated protein complex assembly TAS 10747865
genes like me logo Genes that share ontologies with THEG: view

No data available for Pathways by source and SIGNOR curated interactions for THEG Gene

Drugs & Compounds for THEG Gene

No Compound Related Data Available

Transcripts for THEG Gene

mRNA/cDNA for THEG Gene

Unigene Clusters for THEG Gene

Theg spermatid protein:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for THEG Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b
SP1: - -
SP3: - - - - -

Relevant External Links for THEG Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for THEG Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for THEG Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for THEG Gene

This gene is overexpressed in Testis (x46.5).

Protein differential expression in normal tissues from HIPED for THEG Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (67.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for THEG Gene

Protein tissue co-expression partners for THEG Gene

NURSA nuclear receptor signaling pathways regulating expression of THEG Gene:


SOURCE GeneReport for Unigene cluster for THEG Gene:


mRNA Expression by UniProt/SwissProt for THEG Gene:

Tissue specificity: Testis specific.
genes like me logo Genes that share expression patterns with THEG: view

Primer Products

No data available for Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for THEG Gene

Orthologs for THEG Gene

This gene was present in the common ancestor of chordates.

Orthologs for THEG Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia THEG 34 35
  • 99.21 (n)
(Bos Taurus)
Mammalia THEG 34 35
  • 77.4 (n)
(Canis familiaris)
Mammalia THEG 34 35
  • 76.54 (n)
(Mus musculus)
Mammalia Theg 34 16 35
  • 76.46 (n)
(Rattus norvegicus)
Mammalia Theg 34
  • 69.7 (n)
(Monodelphis domestica)
Mammalia THEG 35
  • 44 (a)
(Ornithorhynchus anatinus)
Mammalia THEG 35
  • 34 (a)
(Danio rerio)
Actinopterygii THEG 35
  • 28 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 30 (a)
Species where no ortholog for THEG was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for THEG Gene

Gene Tree for THEG (if available)
Gene Tree for THEG (if available)

Paralogs for THEG Gene

No data available for Paralogs for THEG Gene

Variants for THEG Gene

Sequence variations from dbSNP and Humsavar for THEG Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000184247 -- 367,533(+) CAAAA(C/T)ATCAC intron-variant
rs1000368630 -- 371,419(+) GTCTG(C/T)CTTTC intron-variant, utr-variant-3-prime
rs1000417116 -- 373,271(+) CTATC(C/T)TAGAG intron-variant
rs1000702549 -- 370,669(+) TTATC(A/G)TAACA intron-variant
rs1000760372 -- 366,357(+) GAGTG(A/C)GTGCG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for THEG Gene

Variant ID Type Subtype PubMed ID
dgv3420n100 CNV gain 25217958
esv1010364 CNV insertion 20482838
esv2422333 CNV duplication 17116639
esv2669963 CNV deletion 23128226
esv2758742 CNV gain 17122850
esv3583200 CNV loss 25503493
esv3643348 CNV loss 21293372
nsv1065558 CNV gain 25217958
nsv1127641 CNV deletion 24896259
nsv1134737 CNV deletion 24896259
nsv1146930 CNV deletion 26484159
nsv428360 CNV gain 18775914
nsv509711 CNV insertion 20534489
nsv522660 CNV loss 19592680
nsv577978 CNV gain 21841781
nsv577980 CNV gain 21841781
nsv833702 CNV loss 17160897
nsv953938 CNV deletion 24416366
nsv9660 CNV loss 18304495

Variation tolerance for THEG Gene

Residual Variation Intolerance Score: 98.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.16; 80.76% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for THEG Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for THEG Gene

Disorders for THEG Gene

Relevant External Links for THEG

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for THEG Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for THEG Gene

Publications for THEG Gene

  1. Alternative splicing, chromosome assignment and subcellular localization of the testicular haploid expressed gene (THEG). (PMID: 11173852) Mannan A. … Burfeind P. (Cytogenet. Cell Genet. 2000) 2 3 4 64
  2. Insertional mutation of the murine kisimo locus caused a defect in spermatogenesis. (PMID: 10747865) Yanaka N. … Mori C. (J. Biol. Chem. 2000) 3 4 64
  3. Next-generation sequencing to generate interactome datasets. (PMID: 21516116) Yu H. … Vidal M. (Nat. Methods 2011) 3 64
  4. An empirical framework for binary interactome mapping. (PMID: 19060904) Venkatesan K. … Vidal M. (Nat. Methods 2009) 3 64
  5. Towards a proteome-scale map of the human protein-protein interaction network. (PMID: 16189514) Rual J.F. … Vidal M. (Nature 2005) 3 64

Products for THEG Gene

Sources for THEG Gene

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