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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

THEG Gene

protein-coding   GIFtS: 46
GCID: GC19M000313

theg spermatid protein

(Previous name: Theg homolog (mouse) )
  Search for THEG
in our new
 Human Malady Compendium 
Biological research products
for THEG
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Theg Spermatid Protein1 2     Theg Homolog (Mouse)1
CT561 2 3     Testicular Haploid Expressed Gene Protein2
THEG11 2     Testis-Specific1
Cancer/Testis Antigen 562 3     Theg Homolog2

External Ids:    HGNC: 137061   Entrez Gene: 512982   Ensembl: ENSG000001055497   OMIM: 6095035   UniProtKB: Q9P2T03   

Export aliases for THEG gene to outside databases

Previous GC identifers: GC19M000302 GC19M000131


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for THEG:
This gene is specifically expressed in the nucleus of haploid male germ cells. The orthologous gene in mice encodes a
protein that may play a role in protein assembly through interactions with T-complex protein 1 subunit epsilon.
Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. (provided by
RefSeq, Nov 2011)

UniProtKB/Swiss-Prot: THEG_HUMAN, Q9P2T0
Function: May be involved (but not essential) in spermatogenesis (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.1  NT_011255.14  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the THEG gene promoter:
         AP-1   ATF-2   SEF-1 (1)   Olf-1   c-Jun   HNF-4alpha1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTHEG promoter sequence
   Search SABiosciences Chromatin IP Primers for THEG

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat THEG


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.3   Ensembl cytogenetic band:  19p13.3   HGNC cytogenetic band: 19p13.3

THEG Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
THEG gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M000313:  view genomic region     (about GC identifiers)

Start:
361,750 bp from pter      End:
376,013 bp from pter
Size:
14,264 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: THEG_HUMAN, Q9P2T0 (See protein sequence)
Recommended Name: Testicular haploid expressed gene protein  
Size: 379 amino acids; 43444 Da
Subunit: Interacts with CCT5 (By similarity)
Subcellular location: Nucleus (By similarity). Note=Localized predominantly in the nucleus of haploid round spermatid
(By similarity)
Secondary accessions: A6NMJ8
Alternative splicing: 2 isoforms:  Q9P2T0-1   Q9P2T0-2   

Explore the universe of human proteins at neXtProt for THEG: NX_Q9P2T0

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9P2T0

  • THEG Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_057669.1  NP_954672.1  

    ENSEMBL proteins: 
     ENSP00000340088   ENSP00000264820  

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    Uscn Proteins for THEG

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--


    THEG for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    THEG for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR006623 THEG

    Graphical View of Domain Structure for InterPro Entry Q9P2T0

    ProtoNet protein and cluster: Q9P2T0

    UniProtKB/Swiss-Prot: THEG_HUMAN, Q9P2T0
    Similarity: Contains 6 THEG repeats


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: THEG_HUMAN, Q9P2T0
    Function: May be involved (but not essential) in spermatogenesis (By similarity)

    miRNA
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    hsa-miR-609
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    Inhib. RNA
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    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI19060904


    THEG for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for THEG:
     Decreased Wnt reporter activit  Increased cell number in G2M,  

    Animal Models:
         Mouse knock-outs for THEG: Thegtm2Wen Thegtm1Wen
         3 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Theg):
     endocrine/exocrine gland  normal  reproductive system 

    THEG for phenotypes           About GeneDecksing


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for THEG

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for THEG (Q9P2T01, 2, 3 ENSP000003400884) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MDFIQ997501, 2, 3, ENSP000002303214EBI-751020,EBI-724076 MINT-67996 I2D: score=5 STRING: ENSP00000230321
    CCT5P486433, ENSP000002803264I2D: score=4 STRING: ENSP00000280326
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007275multicellular organismal development IEA--
    GO:0007283spermatogenesis IEA--
    GO:0030154cell differentiation IEA--
    GO:0051131chaperone-mediated protein complex assembly TAS10747865


    THEG for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for THEG
    Search CenterWatch for drugs/clinical trials and news about THEG 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for THEG gene (2 alternative transcripts): 
    NM_016585.4  NM_199202.2  

    Unigene Cluster for THEG:

    Theg spermatid protein
    Hs.250002  [show with all ESTs]
    Unigene Representative Sequence: NM_016585
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000342640(uc002lol.3 uc002lom.3) ENST00000530711 ENST00000346878
    ENST00000528213

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    1 QIAGEN miScript miRNA Assays for microRNA that regulate THEG:
    hsa-miR-609
    SwitchGear 3'UTR luciferase reporter plasmidTHEG 3' UTR sequence
    Inhib. RNA
    Products:
         
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for THEG (see all 7)
    OriGene shRNA RFP: THEG
    OriGene siRNA: THEG
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    Clone
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    Primer
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    Additional cDNA sequence: 

    AB033129.1 AF268610.1 BC028574.2 

    2 DOTS entries:

    DT.75151807  DT.101975273 

    13 AceView cDNA sequences:

    AF268610 AB033129 BC028574 BQ436576 NM_016585 NM_199202 BI829530 BP356751 
    BE792048 AW592414 BG716992 AI377385 AW173089 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for THEG    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b
    SP1:        -           -                                             
    SP2:                                                                  
    SP3:                    -     -     -     -     -                     


    ECgene alternative splicing isoforms for THEG

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    THEG expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TCTGAGGTGT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image

    THEG expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    TestisSeminiferous TubulesElongated SpermatidGerm Cells, Male Gametocytes
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See THEG Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for THEG

    SOURCE GeneReport for Unigene cluster: Hs.250002

    UniProtKB/Swiss-Prot: THEG_HUMAN, Q9P2T0
    Tissue specificity: Testis specific

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for THEG

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for THEG gene from 2/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Theg1 , 5 testicular haploid expressed gene1, 5 71.07(n)1
    62.92(a)1
      10 (39.72 cM)5
    218301  NM_011583.31  NP_035713.11 
     795763795 
    zebrafish
    (Danio rerio)
    Actinopterygii si:ch211-137c4.46
    si:ch211-137c4.4
    27(a)
    1 ↔ 1
    2(52669981-52687014)


    ENSEMBL Gene Tree for THEG (if available)
    TreeFam Gene Tree for THEG (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/589 NCBI SNPs in THEG are shown (see all 589    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs764412821,2
    F--361648(+) GGAGCG/ATCGGC 2 -- int11Minor allele frequency- A:0.50NA 4
    rs129769181,2
    F--361697(+) CGTGGC/GCCCTC 2 -- int13Minor allele frequency- G:0.38NA 8
    rs129771131,2
    --361705(+) CTCAGC/GAGGAG 2 -- int12Minor allele frequency- G:0.17NA 6
    rs1826804151,2
    --361710(+) GAGGAA/GCGTCA 2 -- int10--------
    rs1459425951,2
    --361712(+) GGAGCA/GTCAGC 2 -- int10--------
    rs772513191,2
    F,--361715(+) GCGTCG/AGCTGC 2 -- int12Minor allele frequency- A:0.50NA 6
    rs129859641,2
    --361720(+) AGCTGG/CTTTGA 2 -- int12Minor allele frequency- C:0.17NA 6
    rs1931699661,2
    --361747(+) GACTCC/TGACGG 2 -- int10--------
    rs1837333871,2
    --361751(+) CCGACA/GGTCCC 2 -- int10--------
    rs129860181,2
    --361784(+) GGCTGG/CTTTGA 2 -- int11Minor allele frequency- C:0.50NA 2

    HapMap Linkage Disequilibrium report for THEG (361750 - 376013 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for THEG
         2 CNVs: 4065 32228

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    THEG for disorders           About MalaCards

    THEG for disorders           About GeneDecksing

    OMIM gene information: 609503    OMIM disorders: --


    Export disorders for THEG gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for THEG gene integrated from 9 sources:
    (articles sorted by number of sources associating them with THEG)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Alternative splicing, chromosome assignment and subcellular localization of the testicular haploid expressed gene (THEG). (PubMed id 11173852)1, 2, 3 Mannan A....Burfeind P. (2000)
    2. Insertional mutation of the murine kisimo locus caused a defect in spermatogenesis. (PubMed id 10747865)1, 2 Yanaka N....Mori C. (2000)
    3. An empirical framework for binary interactome mapping . (PubMed id 19060904)1 Venkatesan K....Vidal M. (2009)
    4. Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (2005)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    6. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)2 Grimwood J.... Lucas S.M. (2004)
    7. Male mice lacking the Theg (testicular haploid expressed gene) protein undergo normal spermatogenesis and are fertile. (PubMed id 12748127)1 Mannan A.U....Engel W. (2003)
    8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 51298 HGNC: 13706 AceView: THEG Ensembl:ENSG00000105549 euGenes: HUgn51298
    ECgene: THEG H-InvDB: THEG

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for THEG Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for THEG gene:
    Search GeneIP for patents involving THEG

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
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    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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    VWF
    (GIFTS: 73)
    von Willebrand factor
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