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Aliases for THBS4 Gene

Aliases for THBS4 Gene

  • Thrombospondin 4 2 3 5
  • TSP4 3 4
  • Thrombospondin-4 3
  • TSP-4 3

External Ids for THBS4 Gene

Previous GeneCards Identifiers for THBS4 Gene

  • GC05P078134
  • GC05P079570
  • GC05P079369
  • GC05P079415
  • GC05P079366
  • GC05P079287
  • GC05P074539

Summaries for THBS4 Gene

Entrez Gene Summary for THBS4 Gene

  • The protein encoded by this gene belongs to the thrombospondin protein family. Thrombospondin family members are adhesive glycoproteins that mediate cell-to-cell and cell-to-matrix interactions. This protein forms a pentamer and can bind to heparin and calcium. It is involved in local signaling in the developing and adult nervous system, and it contributes to spinal sensitization and neuropathic pain states. This gene is activated during the stromal response to invasive breast cancer. It may also play a role in inflammatory responses in Alzheimer's disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]

GeneCards Summary for THBS4 Gene

THBS4 (Thrombospondin 4) is a Protein Coding gene. Diseases associated with THBS4 include Mycetoma and Myocardial Infarction. Among its related pathways are PI3K-Akt signaling pathway and RET signaling. Gene Ontology (GO) annotations related to this gene include calcium ion binding and heparin binding. An important paralog of this gene is THBS3.

UniProtKB/Swiss-Prot for THBS4 Gene

  • Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions and is involved in various processes including cellular proliferation, migration, adhesion and attachment, inflammatory response to CNS injury, regulation of vascular inflammation and adaptive responses of the heart to pressure overload and in myocardial function and remodeling. Binds to structural extracellular matrix (ECM) proteins and modulates the ECM in response to tissue damage, contributing to cardioprotective and adaptive ECM remodeling. Plays a role in ER stress response, via its interaction with the activating transcription factor 6 alpha (ATF6) which produces adaptive ER stress response factors and protects myocardium from pressure overload. May contribute to spinal presynaptic hypersensitivity and neuropathic pain states after peripheral nerve injury. May play a role in regulating protective astrogenesis from the subventricular zone (SVZ) niche after injury in a NOTCH1-dependent manner (By similarity).

Gene Wiki entry for THBS4 Gene

Additional gene information for THBS4 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for THBS4 Gene

Genomics for THBS4 Gene

GeneHancer (GH) Regulatory Elements for THBS4 Gene

Promoters and enhancers for THBS4 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05I079989 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 550.8 -0.3 -345 2.1 HDGF MLX ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 KLF13 SP3 MTX3 THBS4 LINC01455
GH05I080035 Promoter 0.6 EPDnew 560.5 +44.0 44018 0.1 EZH2 THBS4 CTD-2201I18.1 MTX3 ENSG00000251675 TRMT112P2
GH05I079955 Enhancer 0.7 ENCODE 38.3 -34.8 -34791 2 ZBTB21 ZIC2 HIC1 ZNF335 CTBP1 GATA3 ZNF366 POLR2A ATF7 FOSL2 THBS4 CTD-2201I18.1 LINC01455 MTX3 LOC105379048
GH05I080251 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 10.3 +263.9 263878 7.7 HDGF PKNOX1 SMAD1 ARID4B SIN3A ZNF2 YY1 POLR2B ZNF766 E2F8 GC05P080257 SERINC5 PAPD4 RPS3AP20 MTX3 ENSG00000251675 CTD-2201I18.1 THBS4 DHFR GC05P080258
GH05I080092 Enhancer 0.9 Ensembl ENCODE 24.6 +101.2 101229 1.1 CTCF ZNF384 ZNF2 RAD21 TEAD3 CC2D1A ARID2 SMC3 PRDM10 ZNF362 THBS4 ENSG00000251675 SERINC5 CTD-2201I18.1 GC05P080097
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around THBS4 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the THBS4 gene promoter:

Genomic Locations for THBS4 Gene

Genomic Locations for THBS4 Gene
chr5:79,991,311-80,083,637
(GRCh38/hg38)
Size:
92,327 bases
Orientation:
Plus strand
chr5:79,287,134-79,379,110
(GRCh37/hg19)

Genomic View for THBS4 Gene

Genes around THBS4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
THBS4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for THBS4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for THBS4 Gene

Proteins for THBS4 Gene

  • Protein details for THBS4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P35443-TSP4_HUMAN
    Recommended name:
    Thrombospondin-4
    Protein Accession:
    P35443
    Secondary Accessions:
    • B2R909
    • Q86TG2

    Protein attributes for THBS4 Gene

    Size:
    961 amino acids
    Molecular mass:
    105869 Da
    Quaternary structure:
    • Homopentamer; disulfide-linked. Interacts with PTBP3. Interacts with NOTCH1 (By similarity). Interacts (via EGF-like 3; calcium-binding domain) with ATF6 and facilitates its processing, activation and nuclear translocation.

neXtProt entry for THBS4 Gene

Post-translational modifications for THBS4 Gene

  • Glycosylation at isoforms=612 and posLast=941941

Other Protein References for THBS4 Gene

Antibody Products

  • R&D Systems Antibodies for THBS4 (Thrombospondin-4)
  • Abcam antibodies for THBS4

No data available for DME Specific Peptides for THBS4 Gene

Domains & Families for THBS4 Gene

Gene Families for THBS4 Gene

Human Protein Atlas (HPA):
  • Cancer-related genes
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for THBS4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P35443

UniProtKB/Swiss-Prot:

TSP4_HUMAN :
  • Belongs to the thrombospondin family.
Family:
  • Belongs to the thrombospondin family.
genes like me logo Genes that share domains with THBS4: view

Function for THBS4 Gene

Molecular function for THBS4 Gene

GENATLAS Biochemistry:
thrombospondin 4,cell adhesion molecule expressed in heart,skeletal muscle,bone tissues
UniProtKB/Swiss-Prot Function:
Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions and is involved in various processes including cellular proliferation, migration, adhesion and attachment, inflammatory response to CNS injury, regulation of vascular inflammation and adaptive responses of the heart to pressure overload and in myocardial function and remodeling. Binds to structural extracellular matrix (ECM) proteins and modulates the ECM in response to tissue damage, contributing to cardioprotective and adaptive ECM remodeling. Plays a role in ER stress response, via its interaction with the activating transcription factor 6 alpha (ATF6) which produces adaptive ER stress response factors and protects myocardium from pressure overload. May contribute to spinal presynaptic hypersensitivity and neuropathic pain states after peripheral nerve injury. May play a role in regulating protective astrogenesis from the subventricular zone (SVZ) niche after injury in a NOTCH1-dependent manner (By similarity).

Phenotypes From GWAS Catalog for THBS4 Gene

Gene Ontology (GO) - Molecular Function for THBS4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005178 integrin binding IDA 16099885
GO:0005509 calcium ion binding IDA,IEA 7852353
GO:0005515 protein binding IPI 22682248
GO:0008083 growth factor activity IEA --
GO:0008201 heparin binding IDA 7852353
genes like me logo Genes that share ontologies with THBS4: view
genes like me logo Genes that share phenotypes with THBS4: view

Animal Models for THBS4 Gene

MGI Knock Outs for THBS4:

miRNA for THBS4 Gene

miRTarBase miRNAs that target THBS4

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for THBS4 Gene

Localization for THBS4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for THBS4 Gene

Endoplasmic reticulum. Sarcoplasmic reticulum. Secreted. Secreted, extracellular space. Secreted, extracellular space, extracellular matrix.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for THBS4 gene
Compartment Confidence
extracellular 5
endoplasmic reticulum 4
plasma membrane 3
cytoskeleton 1
mitochondrion 1
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for THBS4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS,IEA --
GO:0005578 proteinaceous extracellular matrix IEA --
GO:0005604 basement membrane IDA 17927980
GO:0005615 extracellular space IDA,IEA 12952849
GO:0005783 endoplasmic reticulum ISS --
genes like me logo Genes that share ontologies with THBS4: view

Pathways & Interactions for THBS4 Gene

genes like me logo Genes that share pathways with THBS4: view

Pathways by source for THBS4 Gene

1 BioSystems pathway for THBS4 Gene
2 Reactome pathways for THBS4 Gene
1 R&D Systems pathway for THBS4 Gene

Gene Ontology (GO) - Biological Process for THBS4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001938 positive regulation of endothelial cell proliferation IDA 12952849
GO:0006986 response to unfolded protein IEA --
GO:0007155 cell adhesion IEA --
GO:0010469 regulation of receptor activity IEA --
GO:0016525 negative regulation of angiogenesis IEP 18802666
genes like me logo Genes that share ontologies with THBS4: view

No data available for SIGNOR curated interactions for THBS4 Gene

Drugs & Compounds for THBS4 Gene

(6) Drugs for THBS4 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with THBS4: view

Transcripts for THBS4 Gene

Unigene Clusters for THBS4 Gene

Thrombospondin 4:
Representative Sequences:

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for THBS4 Gene

No ASD Table

Relevant External Links for THBS4 Gene

GeneLoc Exon Structure for
THBS4
ECgene alternative splicing isoforms for
THBS4

Expression for THBS4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for THBS4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for THBS4 Gene

This gene is overexpressed in Heart - Left Ventricle (x6.9), Muscle - Skeletal (x5.5), and Nerve - Tibial (x5.4).

Protein differential expression in normal tissues from HIPED for THBS4 Gene

This gene is overexpressed in Synovial fluid (14.1), Monocytes (9.0), Colon (8.3), and Plasma (7.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for THBS4 Gene



NURSA nuclear receptor signaling pathways regulating expression of THBS4 Gene:

THBS4

SOURCE GeneReport for Unigene cluster for THBS4 Gene:

Hs.211426

Evidence on tissue expression from TISSUES for THBS4 Gene

  • Heart(4.6)
  • Nervous system(4.5)
  • Muscle(3.2)
genes like me logo Genes that share expression patterns with THBS4: view

Primer Products

No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for THBS4 Gene

Orthologs for THBS4 Gene

This gene was present in the common ancestor of animals.

Orthologs for THBS4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia THBS4 33 34
  • 98.89 (n)
dog
(Canis familiaris)
Mammalia THBS4 33 34
  • 90.27 (n)
cow
(Bos Taurus)
Mammalia THBS4 33 34
  • 88.75 (n)
rat
(Rattus norvegicus)
Mammalia Thbs4 33
  • 87.34 (n)
mouse
(Mus musculus)
Mammalia Thbs4 33 16 34
  • 87.3 (n)
oppossum
(Monodelphis domestica)
Mammalia THBS4 34
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 36 (a)
ManyToMany
chicken
(Gallus gallus)
Aves THBS4 33 34
  • 73.9 (n)
lizard
(Anolis carolinensis)
Reptilia THBS4 34
  • 76 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia thbs4 33
  • 71.7 (n)
African clawed frog
(Xenopus laevis)
Amphibia LOC397943 33
zebrafish
(Danio rerio)
Actinopterygii thbs4b 33 34
  • 68.24 (n)
thbs4a 34
  • 63 (a)
OneToMany
thbs4 33
fruit fly
(Drosophila melanogaster)
Insecta Tsp 35 34
  • 53 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 59 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3131 33
Species where no ortholog for THBS4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for THBS4 Gene

ENSEMBL:
Gene Tree for THBS4 (if available)
TreeFam:
Gene Tree for THBS4 (if available)

Paralogs for THBS4 Gene

Paralogs for THBS4 Gene

(5) SIMAP similar genes for THBS4 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with THBS4: view

Variants for THBS4 Gene

Sequence variations from dbSNP and Humsavar for THBS4 Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
rs745310807 uncertain-significance, Hirschsprung disease 1 80,073,320(+) C/T coding_sequence_variant, stop_gained
rs1000061489 -- 80,003,899(+) A/G genic_upstream_transcript_variant, intron_variant
rs1000134493 -- 80,013,893(+) C/A genic_upstream_transcript_variant, intron_variant
rs1000187041 -- 80,013,661(+) C/T genic_upstream_transcript_variant, intron_variant
rs1000200550 -- 80,059,915(+) C/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for THBS4 Gene

Variant ID Type Subtype PubMed ID
esv2287240 CNV deletion 18987734
esv3570228 CNV loss 25503493
esv3605549 CNV loss 21293372
esv3890662 CNV loss 25118596
nsv4894 CNV insertion 18451855
nsv598743 CNV loss 21841781

Variation tolerance for THBS4 Gene

Residual Variation Intolerance Score: 40% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.43; 77.27% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for THBS4 Gene

Human Gene Mutation Database (HGMD)
THBS4
SNPedia medical, phenotypic, and genealogical associations of SNPs for
THBS4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for THBS4 Gene

Disorders for THBS4 Gene

MalaCards: The human disease database

(2) MalaCards diseases for THBS4 Gene - From: HGMD, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
mycetoma
  • madura foot
myocardial infarction
  • myocardial infarction, susceptibility to
- elite association - COSMIC cancer census association via MalaCards
Search THBS4 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for THBS4

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with THBS4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for THBS4 Gene

Publications for THBS4 Gene

  1. Characterization of human thrombospondin-4. (PMID: 7852353) Lawler J … Derick L (The Journal of biological chemistry 1995) 2 3 4 22 58
  2. Polymorphisms in genes involved in innate immunity predispose toward mycetoma susceptibility. (PMID: 17709521) van de Sande WW … van Belkum A (Journal of immunology (Baltimore, Md. : 1950) 2007) 3 22 44 58
  3. Thrombospondin-4 1186G>C (A387P) is a sex-dependent risk factor for myocardial infarction: a large replication study with increased sample size from the same population. (PMID: 16923428) Cui J … Xie YG (American heart journal 2006) 3 22 44 58
  4. Association of common promoter polymorphisms of MCP1 with hepatitis B virus clearance. (PMID: 17202846) Park BL … Shin HD (Experimental & molecular medicine 2006) 3 22 44 58
  5. Thrombospondin-4 A387P polymorphism is not associated with coronary artery disease and myocardial infarction in the Chinese Han population. (PMID: 14674882) Zhou X … Gu D (Clinical science (London, England : 1979) 2004) 3 22 44 58

Products for THBS4 Gene

  • Addgene plasmids for THBS4

Sources for THBS4 Gene

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