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THBS4 Gene

protein-coding   GIFtS: 63
GCID: GC05P079287

Thrombospondin 4

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Thrombospondin 41 2
TSP42 3
thrombospondin-42

External Ids:    HGNC: 117881   Entrez Gene: 70602   Ensembl: ENSG000001132967   OMIM: 6007155   UniProtKB: P354433   
ORGUL members:         

Export aliases for THBS4 gene to outside databases

Previous GC identifers: GC05P078134 GC05P079570 GC05P079369 GC05P079415 GC05P079366 GC05P074539


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for THBS4 Gene:
The protein encoded by this gene belongs to the thrombospondin protein family. Thrombospondin family members are
adhesive glycoproteins that mediate cell-to-cell and cell-to-matrix interactions. This protein forms a pentamer
and can bind to heparin and calcium. Studies of the rat counterpart suggest that this protein may be involved in
local signaling in the developing and adult nervous system. (provided by RefSeq, Jul 2008)

GeneCards Summary for THBS4 Gene:
THBS4 (thrombospondin 4) is a protein-coding gene. Diseases associated with THBS4 include mycetoma, and hypertrophic scars. GO annotations related to this gene include heparin binding and calcium ion binding. An important paralog of this gene is THBS1.

UniProtKB/Swiss-Prot: TSP4_HUMAN, P35443
Function: Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions and is involved in
various processes including cellular proliferation, migration, adhesion and attachment, inflammatory response to
CNS injury, regulation of vascular inflammation and adaptive responses of the heart to pressure overload and in
myocardial function and remodeling. Binds to structural extracellular matrix (ECM) proteins and modulates the ECM
in response to tissue damage, contributing to cardioprotective and adaptive ECM remodeling. Plays a role in ER
stress response, via its interaction with the activating transcription factor 6 alpha (ATF6) which produces
adaptive ER stress response factors and protects myocardium from pressure overload. May contribute to spinal
presynaptic hypersensitivity and neuropathic pain states after peripheral nerve injury. May play a role in
regulating protective astrogenesis from the subventricular zone (SVZ) niche after injury in a NOTCH1-dependent
manner (By similarity)

Gene Wiki entry for THBS4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000005.10  NC_018916.2  NT_034772.7  
Regulatory elements:
   Regulatory transcription factor binding sites in the THBS4 gene promoter:
         RFX1   Pbx1a   AML1a   MEF-2   HSF1 (long)   MEF-2A   HSF1short   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTHBS4 promoter sequence
   Search Chromatin IP Primers for THBS4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat THBS4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q13   Ensembl cytogenetic band:  5q14.1   HGNC cytogenetic band: 5q13

THBS4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
THBS4 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P079287:  view genomic region     (about GC identifiers)

Start:
79,287,134 bp from pter      End:
79,379,110 bp from pter
Size:
91,977 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: TSP4_HUMAN, P35443 (See protein sequence)
Recommended Name: Thrombospondin-4 precursor  
Size: 961 amino acids; 105869 Da
Subunit: Homopentamer; disulfide-linked. Interacts with PTBP3. Interacts with NOTCH1 (By similarity). Interacts
(via EGF-like 3; calcium-binding domain) with ATF6 and facilitates its processing, activation and nuclear
translocation
Secondary accessions: B2R909 Q86TG2

Explore the universe of human proteins at neXtProt for THBS4: NX_P35443

Explore proteomics data for THBS4 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn612, Asn941

  • See THBS4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_003239.2  
    ENSEMBL proteins: 
     ENSP00000339730   ENSP00000422298  
    Reactome Protein details: P35443

    THBS4 Human Recombinant Protein Products:

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    Cloud-Clone Corp. CLIAs for THBS4


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    Selected InterPro protein domains (see all 11):
     IPR001881 EGF-like_Ca-bd_dom
     IPR000742 EG-like_dom
     IPR013320 ConA-like_subgrp
     IPR001791 Laminin_G
     IPR013032 EGF-like_CS

    Graphical View of Domain Structure for InterPro Entry P35443

    ProtoNet protein and cluster: P35443

    3 Blocks protein domains:
    IPB001881 EGF-like calcium-binding
    IPB003129 Thrombospondin
    IPB008859 Thrombospondin


    UniProtKB/Swiss-Prot: TSP4_HUMAN, P35443
    Similarity: Belongs to the thrombospondin family
    Similarity: Contains 4 EGF-like domains
    Similarity: Contains 1 laminin G-like domain
    Similarity: Contains 1 TSP C-terminal (TSPC) domain
    Similarity: Contains 8 TSP type-3 repeats


    THBS4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TSP4_HUMAN, P35443
    Function: Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions and is involved in
    various processes including cellular proliferation, migration, adhesion and attachment, inflammatory response to
    CNS injury, regulation of vascular inflammation and adaptive responses of the heart to pressure overload and in
    myocardial function and remodeling. Binds to structural extracellular matrix (ECM) proteins and modulates the ECM
    in response to tissue damage, contributing to cardioprotective and adaptive ECM remodeling. Plays a role in ER
    stress response, via its interaction with the activating transcription factor 6 alpha (ATF6) which produces
    adaptive ER stress response factors and protects myocardium from pressure overload. May contribute to spinal
    presynaptic hypersensitivity and neuropathic pain states after peripheral nerve injury. May play a role in
    regulating protective astrogenesis from the subventricular zone (SVZ) niche after injury in a NOTCH1-dependent
    manner (By similarity)

         Genatlas biochemistry entry for THBS4:
    thrombospondin 4,cell adhesion molecule expressed in heart,skeletal muscle,bone tissues

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005178integrin binding IDA16099885
    GO:0005509calcium ion binding IDA16246837
    GO:0005515protein binding IPI--
    GO:0008083growth factor activity IEA--
    GO:0008201heparin binding IDA7852353
         
    THBS4 for ontologies           About GeneDecksing


    Phenotypes:
         5 MGI mutant phenotypes (inferred from 1 allele(MGI details for Thbs4):
     cardiovascular system  growth/size/body  hematopoietic system  homeostasis/metabolism  muscle 

    THBS4 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for THBS4
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for THBS4
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    miRNA
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    5 qRT-PCR Assays for microRNAs that regulate THBS4:
    hsa-miR-181c hsa-miR-181a hsa-miR-181d hsa-miR-4262 hsa-miR-181b
    SwitchGear 3'UTR luciferase reporter plasmidTHBS4 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat THBS4

    Gene Editing
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    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for THBS4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat THBS4

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for THBS4


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TSP4_HUMAN, P35443: Endoplasmic reticulum (By similarity). Sarcoplasmic reticulum (By similarity). Secreted.
    Secreted, extracellular space (By similarity). Secreted, extracellular space, extracellular matrix (By
    similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    plasma membrane3
    cytoskeleton1
    mitochondrion1
    nucleus1
    peroxisome1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005604basement membrane IDA17927980
    GO:0005615extracellular space IDA12952849
    GO:0005783endoplasmic reticulum ISS--
    GO:0016529sarcoplasmic reticulum ISS--

    THBS4 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for THBS4 About   (see all 7)  
    See pathways by source

    SuperPathContained pathways About
    1Focal adhesion
    Focal adhesion0.65
    ECM-receptor interaction0.31
    Focal Adhesion0.65
    2Signaling by FGFR
    Signaling by PDGF0.87
    3Signaling by GPCR
    Signal Transduction0.58
    4PI3K-Akt signaling pathway
    PI3K-Akt signaling pathway
    5Phagosome
    Phagosome

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for THBS4
        Notch Signaling Pathways


    1 BioSystems Pathway for THBS4
        Focal Adhesion

    1 Reactome Pathway for THBS4
        Signaling by PDGF


    5 Kegg Pathways  (Kegg details for THBS4):
        Phagosome
    PI3K-Akt signaling pathway
    Focal adhesion
    ECM-receptor interaction
    Malaria


    THBS4 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including THBS4: 
              Atherosclerosis in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for THBS4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for THBS4 (P354433 ENSP000003397304) via UniProtKB, MINT, STRING, and/or I2D (see all 35)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CACNA2D2Q9NY473, ENSP000003903294I2D: score=1 STRING: ENSP00000390329
    PDGFBENSP000003303824STRING: ENSP00000330382
    THBS1ENSP000002603564STRING: ENSP00000260356
    THBS2ENSP000003557514STRING: ENSP00000355751
    THBS3ENSP000003573624STRING: ENSP00000357362
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001938positive regulation of endothelial cell proliferation IDA12952849
    GO:0006986response to unfolded protein IEA--
    GO:0007155cell adhesion ----
    GO:0016525negative regulation of angiogenesis IEP18802666
    GO:0034103regulation of tissue remodeling ISS--

    THBS4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for THBS4 (TSP4)

    6 Novoseek inferred chemical compound relationships for THBS4 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    proline 16.5 4 16099885 (1), 15094117 (1)
    calcium 0 12 16246837 (5), 7852353 (2), 16148025 (1)
    tyrosine 0 1 16138928 (1)
    alanine 0 4 16099885 (1), 15094117 (1)
    serine 0 2 15094117 (1)
    heparin 0 1 7852353 (1)



    THBS4 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for THBS4 gene: 
    NM_003248.4  

    Unigene Cluster for THBS4:

    Thrombospondin 4
    Hs.211426  [show with all ESTs]
    Unigene Representative Sequence: BC050456
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000513310 ENST00000510218 ENST00000350881(uc021yaw.1) ENST00000511733
    ENST00000515510 ENST00000504720 ENST00000511888
    miRNA
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    5 qRT-PCR Assays for microRNAs that regulate THBS4:
    hsa-miR-181c hsa-miR-181a hsa-miR-181d hsa-miR-4262 hsa-miR-181b
    SwitchGear 3'UTR luciferase reporter plasmidTHBS4 3' UTR sequence
    Inhib. RNA
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      QuantiFast Probe-based Assays in human, mouse, rat THBS4

    Additional mRNA sequence: 

    AK302842.1 AK313587.1 BC050456.1 Z19585.1 

    9 DOTS entries:

    DT.213234  DT.100024005  DT.100711683  DT.100711682  DT.40261982  DT.91714150  DT.100778846  DT.120864323 
    DT.99950566 

    Selected AceView cDNA sequences (see all 99):

    BQ575643 BU740185 CB043832 BC050456 F29860 BM703838 AA437064 BQ004168 
    BM697959 H27672 H27465 BM722350 BM667123 CD676188 BM698536 CA447187 
    NM_003248 BM667457 BM668816 AA826612 AI718900 AA423957 BQ774281 BF347276 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    THBS4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGGAAGCAGA
    THBS4 Expression
    About this image


    THBS4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 11) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 4 entries
             Chondrocytes Zeugopod Epiphyseal End
             Zeugopod Long Bone
     
     Limb (Muscoskeletal System)    fully expand to see all 2 entries
             Mesenchymal Condensate Cells Zeugopod
             Zeugopod
     
     Cartilage (Muscoskeletal System)    fully expand to see all 2 entries
             Mesenchymal Condensate Cells Zeugopod
     
     Heart (Cardiovascular System)    fully expand to see all 2 entries
             Primitive Heart Tube Cells Primitive Heart Tube
     
     Gut Tube (Gastrointestinal Tract)
             Foregut
    THBS4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    THBS4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.211426
        Pathway & Disease-focused RT2 Profiler PCR Array including THBS4: 
              Atherosclerosis in human mouse rat

    Primer
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    OriGene qPCR primer pairs and template standards for THBS4
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    QuantiFast Probe-based Assays in human, mouse, rat THBS4
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for THBS4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for THBS4 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Thbs41 , 5 thrombospondin 41, 5 87.3(n)1
    92.4(a)1
      13 (47.75 cM)5
    218281  NM_011582.31  NP_035712.11 
     927515905 
    chicken
    (Gallus gallus)
    Aves THBS41 thrombospondin 4 73.9(n)
    76.83(a)
      396306  XM_424763.4  XP_424763.4 
    lizard
    (Anolis carolinensis)
    Reptilia THBS46
    thrombospondin 4
    76(a)
    1 ↔ 1
    2(12477406-12526986)
    African clawed frog
    (Xenopus laevis)
    Amphibia LOC3979432 thrombospondin-4 75.35(n)    Z19091.1 
    zebrafish
    (Danio rerio)
    Actinopterygii thbs42 thrombospondin 4 77.3(n)   252850  AY081009.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Tsp3 cell adhesion molecule 53(a)     --


    ENSEMBL Gene Tree for THBS4 (if available)
    TreeFam Gene Tree for THBS4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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    Paralogs for THBS4 gene
    THBS12  COMP2  THBS32  THBS22  
    5 SIMAP similar genes for THBS4 using alignment to 2 protein entries:     TSP4_HUMAN (see all proteins):
    THBS3    COMP    DKFZp686G02190    THBS2    THBS1

    THBS4 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for THBS4 (see all 1047)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1428435321,2
    --79329196(+) TACATA/CTATAG 1 -- us2k10--------
    rs1510345831,2
    --79329277(+) AATGTC/TATGGC 1 -- us2k10--------
    rs737706921,2
    C,F--79329414(+) TCTTAT/CTGCTC 1 -- us2k12Minor allele frequency- C:0.03WA 120
    rs1397864461,2
    --79329536(+) GGCATC/TCACTA 1 -- us2k10--------
    rs178789191,2
    C,F--79329538(+) CATCCA/GCTAGG 1 -- us2k119Minor allele frequency- G:0.26NS NA WA CSA EA 1126
    rs1875694841,2
    --79329609(+) TGATAC/TAGCAT 1 -- us2k10--------
    rs1927867431,2
    --79329680(+) AAATTC/TCCCAG 1 -- us2k10--------
    rs1497904641,2
    --79329686(+) CCCAGG/TAGATT 1 -- us2k10--------
    rs178786971,2
    C--79329756(+) AAATAT/CTGTCT 1 -- us2k12Minor allele frequency- C:0.01NS 88
    rs559099501,2
    C,F--79329812(+) AGGCAA/GGGCTG 1 -- us2k12Minor allele frequency- G:0.03WA 120

    HapMap Linkage Disequilibrium report for THBS4 (79287134 - 79379110 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10 variations for THBS4:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2287240CNV Deletion18987734
    nsv4894CNV Insertion18451855
    nsv882230CNV Loss21882294
    dgv6187n71CNV Loss21882294
    nsv882225CNV Loss21882294
    nsv882223CNV Loss21882294
    dgv6188n71CNV Loss21882294
    nsv882224CNV Loss21882294
    nsv882220CNV Loss21882294
    nsv882227CNV Loss21882294

    Human Gene Mutation Database (HGMD): THBS4
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing THBS4
    DNA2.0 Custom Variant and Variant Library Synthesis for THBS4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 600715    OMIM disorders: --

    Selected diseases for THBS4 (see all 26):    
    About MalaCards
    mycetoma    hypertrophic scars    mesoblastic nephroma    cutaneous t cell lymphoma
    synovial sarcoma    coronary artery disease    dermatomyositis    wilms tumor
    atherosclerosis    myocardial infarction    coronary heart disease    malaria
    gastric adenocarcinoma    muscular dystrophy    sarcoma    kidney disease
    hepatitis b    retinitis    ovarian cancer    hepatitis


    THBS4 for disorders           About GeneDecksing

    4 Novoseek inferred disease relationships for THBS4 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    coronary artery disease 31.2 1 14674882 (1)
    myocardial infarction 23.7 7 16099885 (1), 14674882 (1), 15131549 (1), 16923428 (1) (see all 5)
    atherosclerosis 0 2 12952849 (1)
    tumors 0 2 15897551 (1), 15302496 (1)

    Genetic Association Database (GAD): THBS4
    Human Genome Epidemiology (HuGE) Navigator: THBS4 (20 documents)

    Export disorders for THBS4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for THBS4 gene, integrated from 10 sources (see all 75):
    (articles sorted by number of sources associating them with THBS4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of human thrombospondin-4. (PubMed id 7852353)1, 2, 3, 9 Lawler J.... Derick L. (J. Biol. Chem. 1995)
    2. Replication of the association between the thrombospondin-4 A387P polymorphism and myocardial infarction. (PubMed id 15131549)1, 4, 9 Wessel J....McCarthy J.J. (Am. Heart J. 2004)
    3. Large scale association analysis for identification of genes underlying premature coronary heart disease: cumulative perspective from analysis of 111 candidate genes. (PubMed id 15121769)1, 4, 9 McCarthy J.J....Topol E.J. (J. Med. Genet. 2004)
    4. Polymorphisms in genes involved in innate immunity predispose toward mycetoma susceptibility. (PubMed id 17709521)1, 4, 9 van de Sande W.W....van Belkum A. (J. Immunol. 2007)
    5. Thrombospondin-4 1186G&gt;C (A387P) is a sex-dependent risk factor for myocardial infarction: a large replication study with increased sample size from the same population. (PubMed id 16923428)1, 4, 9 Cui J....Xie Y.G. (Am. Heart J. 2006)
    6. Association of common promoter polymorphisms of MCP1 with hepatitis B virus clearance. (PubMed id 17202846)1, 4, 9 Park B.L....Shin H.D. (amp 2006)
    7. Thrombospondin-4 A387P polymorphism is not associated with coronary artery disease and myocardial infarction in the Chinese Han population. (PubMed id 14674882)1, 4, 9 Zhou X....Gu D. (Clin. Sci. 2004)
    8. Thrombospondin-4 polymorphism (A387P) predicts cardiovascular risk in postinfarction patients with high HDL cholesterol and C-reactive protein levels. (PubMed id 22011848)1, 2 Corsetti J.P....Sparks C.E. (Thromb. Haemost. 2011)
    9. Common polymorphisms in ITGA2, PON1 and THBS2 are associated with coronary atherosclerosis in a candidate gene association study of the Chinese Han population. (PubMed id 20485444)1, 4 Wang Y....Huang W. (J. Hum. Genet. 2010)
    10. Identification of fetal and maternal single nucleotide polymorphisms in candidate genes that predispose to spontaneous preterm labor with intact membranes. (PubMed id 20452482)1, 4 Romero R....Menon R. (Am. J. Obstet. Gynecol. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 7060 HGNC: 11788 AceView: THBS4 Ensembl:ENSG00000113296 euGenes: HUgn7060
    ECgene: THBS4 Kegg: 7060 H-InvDB: THBS4

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for THBS4 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for THBS4 Genetics and Cytogenetics in Oncology and Haematology
    SeattleSNPshttp://pga.gs.washington.edu/data/thbs4/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for THBS4 gene:
    Search GeneIP for patents involving THBS4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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