Free for academic non-profit institutions. Other users need a Commercial license

Aliases for THBS4 Gene

Aliases for THBS4 Gene

  • Thrombospondin 4 2 3
  • TSP4 3 4
  • Thrombospondin-4 3

External Ids for THBS4 Gene

Summaries for THBS4 Gene

Entrez Gene Summary for THBS4 Gene

  • The protein encoded by this gene belongs to the thrombospondin protein family. Thrombospondin family members are adhesive glycoproteins that mediate cell-to-cell and cell-to-matrix interactions. This protein forms a pentamer and can bind to heparin and calcium. Studies of the rat counterpart suggest that this protein may be involved in local signaling in the developing and adult nervous system. [provided by RefSeq, Jul 2008]

GeneCards Summary for THBS4 Gene

THBS4 (Thrombospondin 4) is a Protein Coding gene. Diseases associated with THBS4 include hypertrophic scars and mycetoma. Among its related pathways are PI3K-Akt signaling pathway and Signaling by FGFR. GO annotations related to this gene include calcium ion binding and heparin binding. An important paralog of this gene is THBS2.

UniProtKB/Swiss-Prot for THBS4 Gene

  • Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions and is involved in various processes including cellular proliferation, migration, adhesion and attachment, inflammatory response to CNS injury, regulation of vascular inflammation and adaptive responses of the heart to pressure overload and in myocardial function and remodeling. Binds to structural extracellular matrix (ECM) proteins and modulates the ECM in response to tissue damage, contributing to cardioprotective and adaptive ECM remodeling. Plays a role in ER stress response, via its interaction with the activating transcription factor 6 alpha (ATF6) which produces adaptive ER stress response factors and protects myocardium from pressure overload. May contribute to spinal presynaptic hypersensitivity and neuropathic pain states after peripheral nerve injury. May play a role in regulating protective astrogenesis from the subventricular zone (SVZ) niche after injury in a NOTCH1-dependent manner (By similarity).

Gene Wiki entry for THBS4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for THBS4 Gene

Genomics for THBS4 Gene

Genomic Location for THBS4 Gene

Start:
79,991,311 bp from pter
End:
80,083,287 bp from pter
Size:
91,977 bases
Orientation:
Plus strand

Genomic View for THBS4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for THBS4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for THBS4 Gene

Regulatory Elements for THBS4 Gene

Proteins for THBS4 Gene

  • Protein details for THBS4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P35443-TSP4_HUMAN
    Recommended name:
    Thrombospondin-4
    Protein Accession:
    P35443
    Secondary Accessions:
    • B2R909
    • Q86TG2

    Protein attributes for THBS4 Gene

    Size:
    961 amino acids
    Molecular mass:
    105869 Da
    Quaternary structure:
    • Homopentamer; disulfide-linked. Interacts with PTBP3. Interacts with NOTCH1 (By similarity). Interacts (via EGF-like 3; calcium-binding domain) with ATF6 and facilitates its processing, activation and nuclear translocation.

neXtProt entry for THBS4 Gene

Proteomics data for THBS4 Gene at MOPED

Post-translational modifications for THBS4 Gene

  • Glycosylation at Asn612 and Asn941

Other Protein References for THBS4 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for THBS4 Gene

Domains for THBS4 Gene

Suggested Antigen Peptide Sequences for THBS4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P35443

UniProtKB/Swiss-Prot:

TSP4_HUMAN
Domain:
  • Contains 4 EGF-like domains.:
    • P35443
  • Contains 1 laminin G-like domain.:
    • P35443
  • Contains 1 TSP C-terminal (TSPC) domain.:
    • P35443
Family:
  • Belongs to the thrombospondin family.:
    • P35443
Similarity:
  • Contains 8 TSP type-3 repeats.:
    • P35443
genes like me logo Genes that share domains with THBS4: view

No data available for Gene Families for THBS4 Gene

Function for THBS4 Gene

Molecular function for THBS4 Gene

GENATLAS Biochemistry: thrombospondin 4,cell adhesion molecule expressed in heart,skeletal muscle,bone tissues
UniProtKB/Swiss-Prot Function: Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions and is involved in various processes including cellular proliferation, migration, adhesion and attachment, inflammatory response to CNS injury, regulation of vascular inflammation and adaptive responses of the heart to pressure overload and in myocardial function and remodeling. Binds to structural extracellular matrix (ECM) proteins and modulates the ECM in response to tissue damage, contributing to cardioprotective and adaptive ECM remodeling. Plays a role in ER stress response, via its interaction with the activating transcription factor 6 alpha (ATF6) which produces adaptive ER stress response factors and protects myocardium from pressure overload. May contribute to spinal presynaptic hypersensitivity and neuropathic pain states after peripheral nerve injury. May play a role in regulating protective astrogenesis from the subventricular zone (SVZ) niche after injury in a NOTCH1-dependent manner (By similarity).

Gene Ontology (GO) - Molecular Function for THBS4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005178 integrin binding IDA 16099885
GO:0005509 calcium ion binding IDA 16246837
GO:0005515 protein binding IPI 22682248
GO:0008083 growth factor activity IEA --
GO:0008201 heparin binding IDA 7852353
genes like me logo Genes that share ontologies with THBS4: view
genes like me logo Genes that share phenotypes with THBS4: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for THBS4 Gene

Localization for THBS4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for THBS4 Gene

Endoplasmic reticulum. Sarcoplasmic reticulum. Secreted. Secreted, extracellular space. Secreted, extracellular space, extracellular matrix.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for THBS4 Gene COMPARTMENTS Subcellular localization image for THBS4 gene
Compartment Confidence
extracellular 5
plasma membrane 3
cytoskeleton 1
mitochondrion 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for THBS4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005604 basement membrane IDA 17927980
GO:0005615 extracellular space IDA 12952849
GO:0005783 endoplasmic reticulum ISS --
GO:0016529 sarcoplasmic reticulum ISS --
genes like me logo Genes that share ontologies with THBS4: view

Pathways for THBS4 Gene

genes like me logo Genes that share pathways with THBS4: view

Pathways by source for THBS4 Gene

1 R&D Systems pathway for THBS4 Gene
1 BioSystems pathway for THBS4 Gene

Interacting Proteins for THBS4 Gene

Gene Ontology (GO) - Biological Process for THBS4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001938 positive regulation of endothelial cell proliferation IDA 12952849
GO:0006986 response to unfolded protein IEA --
GO:0007155 cell adhesion --
GO:0016525 negative regulation of angiogenesis IEP 18802666
GO:0034103 regulation of tissue remodeling ISS --
genes like me logo Genes that share ontologies with THBS4: view

Compounds for THBS4 Gene

(6) Novoseek inferred chemical compound relationships for THBS4 Gene

Compound -log(P) Hits PubMed IDs
proline 16.5 2
calcium 0 8
tyrosine 0 1
alanine 0 2
serine 0 1
genes like me logo Genes that share compounds with THBS4: view

Transcripts for THBS4 Gene

Unigene Clusters for THBS4 Gene

Thrombospondin 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for THBS4 Gene

No ASD Table

Relevant External Links for THBS4 Gene

GeneLoc Exon Structure for
THBS4
ECgene alternative splicing isoforms for
THBS4

Expression for THBS4 Gene

mRNA expression in normal human tissues for THBS4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for THBS4 Gene

This gene is overexpressed in Heart - Left Ventricle (6.9), Muscle - Skeletal (5.5), and Nerve - Tibial (5.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for THBS4 Gene

SOURCE GeneReport for Unigene cluster for THBS4 Gene Hs.211426

genes like me logo Genes that share expressions with THBS4: view

No data available for mRNA Expression by UniProt/SwissProt for THBS4 Gene

Orthologs for THBS4 Gene

This gene was present in the common ancestor of animals.

Orthologs for THBS4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia THBS4 35
  • 98.89 (n)
  • 99.08 (a)
THBS4 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia THBS4 35
  • 88.75 (n)
  • 91.98 (a)
THBS4 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia THBS4 35
  • 90.27 (n)
  • 93.78 (a)
THBS4 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Thbs4 35
  • 87.3 (n)
  • 92.4 (a)
Thbs4 16
Thbs4 36
  • 92 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia THBS4 36
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 36 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Thbs4 35
  • 87.34 (n)
  • 93.34 (a)
chicken
(Gallus gallus)
Aves THBS4 35
  • 73.9 (n)
  • 76.83 (a)
THBS4 36
  • 76 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia THBS4 36
  • 76 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia LOC397943 35
tropical clawed frog
(Silurana tropicalis)
Amphibia thbs4 35
  • 71.7 (n)
  • 75.94 (a)
zebrafish
(Danio rerio)
Actinopterygii thbs4 35
thbs4a 36
  • 63 (a)
OneToMany
thbs4b 35
  • 68.24 (n)
  • 71.85 (a)
thbs4b 36
  • 69 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Tsp 36
  • 37 (a)
OneToMany
Tsp 37
  • 53 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3131 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 59 (a)
OneToMany
Species with no ortholog for THBS4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for THBS4 Gene

ENSEMBL:
Gene Tree for THBS4 (if available)
TreeFam:
Gene Tree for THBS4 (if available)

Paralogs for THBS4 Gene

Paralogs for THBS4 Gene

Selected SIMAP similar genes for THBS4 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with THBS4: view

Variants for THBS4 Gene

Sequence variations from dbSNP and Humsavar for THBS4 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs166270 -- 80,044,756(+) taaat(A/G)ttGAA intron-variant
rs194375 -- 80,044,570(+) tgtgc(A/G)cacca intron-variant
rs256440 -- 80,046,696(+) AAGTC(A/G)CTTAT intron-variant
rs256441 -- 80,046,048(+) CACAC(A/G)TAAGA intron-variant
rs256442 -- 80,045,746(+) GGCTG(A/G)TCTCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for THBS4 Gene

Variant ID Type Subtype PubMed ID
nsv4894 CNV Insertion 18451855
dgv6187n71 CNV Loss 21882294
nsv882220 CNV Loss 21882294
nsv882223 CNV Loss 21882294
nsv882224 CNV Loss 21882294
nsv882225 CNV Loss 21882294
dgv6188n71 CNV Loss 21882294
nsv882227 CNV Loss 21882294
nsv882230 CNV Loss 21882294
esv2287240 CNV Deletion 18987734

Relevant External Links for THBS4 Gene

HapMap Linkage Disequilibrium report
THBS4
Human Gene Mutation Database (HGMD)
THBS4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for THBS4 Gene

Disorders for THBS4 Gene

(4) Novoseek inferred disease relationships for THBS4 Gene

Disease -log(P) Hits PubMed IDs
coronary artery disease 31.2 1
myocardial infarction 23.7 5
atherosclerosis 0 1
tumors 0 2

Relevant External Links for THBS4

Genetic Association Database (GAD)
THBS4
Human Genome Epidemiology (HuGE) Navigator
THBS4
genes like me logo Genes that share disorders with THBS4: view

No data available for UniProtKB/Swiss-Prot for THBS4 Gene

Publications for THBS4 Gene

  1. Characterization of human thrombospondin-4. (PMID: 7852353) Lawler J. … Derick L. (J. Biol. Chem. 1995) 2 3 4 23
  2. Thrombospondin-4 A387P polymorphism is not associated with coronary artery disease and myocardial infarction in the Chinese Han population. (PMID: 14674882) Zhou X. … Gu D. (Clin. Sci. 2004) 3 23 48
  3. Large scale association analysis for identification of genes underlying premature coronary heart disease: cumulative perspective from analysis of 111 candidate genes. (PMID: 15121769) McCarthy J.J. … Topol E.J. (J. Med. Genet. 2004) 3 23 48
  4. Replication of the association between the thrombospondin-4 A387P polymorphism and myocardial infarction. (PMID: 15131549) Wessel J. … McCarthy J.J. (Am. Heart J. 2004) 3 23 48
  5. Thrombospondin-4 1186G>C (A387P) is a sex-dependent risk factor for myocardial infarction: a large replication study with increased sample size from the same population. (PMID: 16923428) Cui J. … Xie Y.G. (Am. Heart J. 2006) 3 23 48

Products for THBS4 Gene

  • Addgene plasmids for THBS4

Sources for THBS4 Gene

Back to Top

Content