Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

THBS4 Gene

protein-coding   GIFtS: 60
GCID: GC05P079287

thrombospondin 4
 Explore 25 diseases affiliated with
THBS4 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for THBS4    

Aliases
for THBS4 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Thrombospondin 41 2
TSP42 3
Thrombospondin-41

External Ids:    HGNC: 117881   Entrez Gene: 70602   Ensembl: ENSG000001132967   OMIM: 6007155   UniProtKB: P354433   

Export aliases for THBS4 gene to outside databases

Previous GC identifers: GC05P078134 GC05P079570 GC05P079369 GC05P079415 GC05P079366 GC05P074539


Summaries
for THBS4 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for THBS4:
The protein encoded by this gene belongs to the thrombospondin protein family. Thrombospondin family members are
adhesive glycoproteins that mediate cell-to-cell and cell-to-matrix interactions. This protein forms a pentamer and
can bind to heparin and calcium. Studies of the rat counterpart suggest that this protein may be involved in local
signaling in the developing and adult nervous system. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: TSP4_HUMAN, P35443
Function: Acts as an extracellular mitogen and stimulates early erythroid progenitors proliferation in presence of EPO.
Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Can bind to fibrinogen, fibronectin,
laminin and type V collagen

Gene Wiki entry for THBS4


Genomic Views
for THBS4 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NC_018916.1  NT_006713.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the THBS4 gene promoter:
         RFX1   Pbx1a   AML1a   MEF-2   HSF1 (long)   MEF-2A   HSF1short   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: THBS4 promoter sequence
   Search SABiosciences Chromatin IP Primers for THBS4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat THBS4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q13   Ensembl cytogenetic band:  5q14.1   HGNC cytogenetic band: 5q13

THBS4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
THBS4 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P079287:  view genomic region     (about GC identifiers)

Start:
 79,287,134 bp from pter      End:
 79,379,110 bp from pter
Size:
 91,977 bases      Orientation:
 plus strand

Proteins
for THBS4 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: TSP4_HUMAN, P35443 (See protein sequence)
Recommended Name: Thrombospondin-4 precursor  
Size: 961 amino acids; 105869 Da
Subunit: Homopentamer; disulfide-linked. Interacts with PTBP3
Secondary accessions: B2R909 Q86TG2

Explore the universe of human proteins at neXtProt for THBS4: NX_P35443

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P35443

    • THBS4 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_003239.2  
    ENSEMBL proteins: 
     ENSP00000339730   ENSP00000422298  
    Reactome Protein details: P35443
    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for THBS4 (Thrombospondin-4)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom Protein Services for THBS4 
    GenScript Custom Purified and Recombinant Proteins Services for THBS4
    Novus Biologicals THBS4 Proteins
    Novus Biologicals THBS4 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for THBS4

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005578proteinaceous extracellular matrix ----
    GO:0005604basement membrane IDA17927980
    GO:0005615extracellular space IDA12952849
    GO:0031594neuromuscular junction ----


    THBS4 for ontologies           About GeneDecksing



    THBS4 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for THBS4 (Thrombospondin-4)
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for THBS4 
    GenScript Custom Superior Antibodies Services for THBS4
    Novus Biologicals THBS4 Antibody
    Search for Antibodies for THBS4 at Abcam  
    Uscn Antibodies for THBS4
    Search ThermoFisher Antibodies for THBS4

    Assay Products for THBS4: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for THBS4
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for THBS4

    Protein Domains /
    Families
    for THBS4 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    THBS4 for domains           About GeneDecksing

    5/11 InterPro domains/families (see all 11):
     IPR001881 EGF-like_Ca-bd
     IPR000742 EG-like_dom
     IPR013320 ConA-like_subgrp
     IPR001791 Laminin_G
     IPR013032 EGF-like_CS

    Graphical View of Domain Structure for InterPro Entry P35443

    ProtoNet protein and cluster: P35443

    3 Blocks protein families:
    IPB001881 EGF-like calcium-binding
    IPB003129 Thrombospondin
    IPB008859 Thrombospondin


    UniProtKB/Swiss-Prot: TSP4_HUMAN, P35443
    Similarity: Belongs to the thrombospondin family
    Similarity: Contains 4 EGF-like domains
    Similarity: Contains 1 laminin G-like domain
    Similarity: Contains 1 TSP C-terminal (TSPC) domain
    Similarity: Contains 8 TSP type-3 repeats


    Function
    for THBS4 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: TSP4_HUMAN, P35443
    Function: Acts as an extracellular mitogen and stimulates early erythroid progenitors proliferation in presence of EPO.
    Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Can bind to fibrinogen, fibronectin,
    laminin and type V collagen

         Genatlas biochemistry entry for THBS4:
    thrombospondin 4,cell adhesion molecule expressed in heart,skeletal muscle,bone tissues

    miRNA
    Products:            		 OriGene 3'-UTR Clone: THBS4
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat THBS4
    5 QIAGEN miScript miRNA Assays for microRNAs that regulate THBS4:
    hsa-miR-181c hsa-miR-181a hsa-miR-181d hsa-miR-4262 hsa-miR-181b
    SwitchGear 3'UTR luciferase reporter plasmid: THBS4 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for THBS4 (see all 4)
    OriGene shRNA RFP: THBS4
    OriGene siRNA: THBS4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat THBS4

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for THBS4

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for THBS4 (see all 2)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for THBS4
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: THBS4 (NM_003248)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for THBS4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat THBS4 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for THBS4
    Search LifeMap BioReagents cell lines for THBS4

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for THBS4

    Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001968fibronectin binding ----
    GO:0005178integrin binding IDA16099885
    GO:0005509calcium ion binding IDA16246837
    GO:0005518collagen binding ----
    GO:0008083growth factor activity IEA--


    THBS4 for ontologies           About GeneDecksing


    Animal Models:
         5 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Thbs4):
     cardiovascular system  growth/size  hematopoietic system  homeostasis/metabolism  muscle 

    THBS4 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for THBS4 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/7 super-pathways (see all 7) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Focal Adhesion
    		Focal Adhesion1.00
    		Focal adhesion0.66
    2Malaria
    		Malaria1.00
    3ECM-receptor interaction
    		ECM-receptor interaction1.00
    4Phagosome
    		Phagosome1.00
    5TGF-beta signaling pathway
    		TGF-beta signaling pathway1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    1 BioSystems Pathway for THBS4 
        Focal Adhesion

    2        Reactome Pathways for THBS4
        Signal Transduction
    Signaling by PDGF


    5         Kegg Pathways  (Kegg details for THBS4):
        Phagosome
    TGF-beta signaling pathway
    Focal adhesion
    ECM-receptor interaction
    Malaria


    THBS4 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for THBS4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/33 Interacting proteins for THBS4 (P354433 ENSP000003397304) via UniProtKB, MINT, STRING, and/or I2D (see all 33)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CACNA2D2Q9NY473I2D: score=1 
    PDGFBENSP000003303824STRING: ENSP00000330382
    THBS1ENSP000002603564STRING: ENSP00000260356
    THBS2ENSP000003557514STRING: ENSP00000355751
    THBS3ENSP000003573624STRING: ENSP00000357362
    About this table

    Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001938positive regulation of endothelial cell proliferation IDA12952849
    GO:0007155cell adhesion ----
    GO:0007399nervous system development ----
    GO:0016525negative regulation of angiogenesis IEP18802666
    GO:0048812neuron projection morphogenesis ----


    THBS4 for ontologies           About GeneDecksing



    Drugs & Compounds
    for THBS4 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    THBS4 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for THBS4
    6 Novoseek chemical compound relationships for THBS4 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    proline 16.5 4 16099885 (1), 15094117 (1)
    calcium 0 12 16246837 (5), 7852353 (2), 16148025 (1)
    tyrosine 0 1 16138928 (1)
    alanine 0 4 16099885 (1), 15094117 (1)
    serine 0 2 15094117 (1)
    heparin 0 1 7852353 (1)

    Search CenterWatch for drugs/clinical trials and news about THBS4 / TSP4 

    Transcripts
    for THBS4 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for THBS4 gene: 
    NM_003248.4  

    Unigene Cluster for THBS4:

    Thrombospondin 4
    Hs.211426  [show with all ESTs]
    Unigene Representative Sequence: BC050456
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000513310 ENST00000510218 ENST00000350881(uc021yaw.1) ENST00000511733
    ENST00000515510 ENST00000504720 ENST00000511888

    miRNA
    Products:             		 OriGene 3'-UTR Clone: THBS4
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat THBS4
    5 QIAGEN miScript miRNA Assays for microRNAs that regulate THBS4:
    hsa-miR-181c hsa-miR-181a hsa-miR-181d hsa-miR-4262 hsa-miR-181b
    SwitchGear 3'UTR luciferase reporter plasmid: THBS4 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for THBS4 (see all 4)
    OriGene shRNA RFP: THBS4
    OriGene siRNA: THBS4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat THBS4
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for THBS4 (see all 2)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for THBS4
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: THBS4 (NM_003248)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for THBS4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat THBS4 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for THBS4
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat THBS4
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat THBS4
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat THBS4

    Additional cDNA sequence: 

    AK302842.1 AK313587.1 BC050456.1 Z19585.1 

    9 DOTS entries:

    DT.213234  DT.100024005  DT.100711683  DT.100711682  DT.40261982  DT.91714150  DT.100778846  DT.120864323 
    DT.99950566 

    24/99 AceView cDNA sequences (see all 99):

    BC050456 CB043832 AI718900 BM667457 BM697959 CD676188 F29860 AA437064 
    BU740185 AA423957 BM722350 NM_003248 BM668816 BM703838 BM667123 CA447187 
    AA826612 H27672 H27465 BQ575643 BQ004168 BM698536 BF347276 BM468464 

    GeneLoc Exon Structure


    Expression
    for THBS4 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    THBS4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TGGAAGCAGA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    THBS4 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    6 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    BoneZeugopod Epiphyseal EndChondrocytesBone, Cartilage
    HeartPrimitive Heart TubePrimitive Heart Tube CellsMyocardium
    LimbZeugopodMesenchymal Condensate CellsBone, Cartilage
    BoneZeugopod Epiphyseal EndBone
    BoneZeugopod Long BoneBone
    LimbZeugopodLimb
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 3 LifeMap Cells 
    NameCategory
    Sclerotome cells (Primary Cell)Bone, Cartilage, Somite
    N2/LSB/S/F8/CHIR-induced cells (Generation of midbra...)
    Intervertebral disc (IVD) annulus fibrosus (AF) cells (Differentiation of s...)Cartilage

    See THBS4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for THBS4

    SOURCE GeneReport for Unigene cluster: Hs.211426
        SABiosciences Expression via Pathway-Focused PCR Array including THBS4: 
              Atherosclerosis in human mouse rat

    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for THBS4
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat THBS4
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat THBS4
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat THBS4
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for THBS4

    Orthologs
    for THBS4 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for THBS4 gene from 6/18 species (see all 18)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Thbs41 , 5 thrombospondin 41, 5 87.37(n)1
    92.51(a)1    		   13 (47.75 cM)5
    218281  NM_011582.31  NP_035712.11 
     927515905 
    chicken
    (Gallus gallus)    		 Aves THBS41 thrombospondin 4 73.5(n)
    76.45(a)    		   396306  XM_424763.3  XP_424763.3 
    lizard
    (Anolis carolinensis)    		 Reptilia THBS46
    		 --
    		 76(a)
    		 1 ↔ 1
    		 2(12478576-12526986)
    African clawed frog
    (Xenopus laevis)    		 Amphibia LOC3979432 thrombospondin-4 75.35(n)    Z19091.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii thbs42 thrombospondin 4 77.3(n)   252850  AY081009.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Tsp3 cell adhesion molecule 53(a)     --


    ENSEMBL Gene Tree for THBS4 (if available)
    TreeFam Gene Tree for THBS4 (if available) 

    Paralogs
    for THBS4 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for THBS4 gene
    THBS12  COMP2  THBS32  THBS22  
    5 SIMAP similar genes for THBS4 using alignment to 2 protein entries:     TSP4_HUMAN (see all proteins):
    THBS3    COMP    DKFZp686G02190    THBS2    THBS1

    THBS4 for paralogs           About GeneDecksing



    Genomic Variants
    for THBS4 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/852 NCBI SNPs in THBS4 are shown (see all 852)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 5 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1428435321,2
    		--79329196(+) TACATA/CTATAG 1 -- us2k10--------
    rs1510345831,2
    		--79329277(+) AATGTC/TATGGC 1 -- us2k10--------
    rs737706921,2
    		C,--79329414(+) TCTTAT/CTGCTC 1 -- us2k12Minor allele frequency- C:0.03WA 120
    rs1397864461,2
    		--79329536(+) GGCATC/TCACTA 1 -- us2k10--------
    rs178789191,2
    		C,F,--79329538(+) CATCCA/GCTAGG 1 -- us2k119Minor allele frequency- G:0.26NS NA WA CSA EA 1126
    rs1875694841,2
    		--79329609(+) TGATAC/TAGCAT 1 -- us2k10--------
    rs1927867431,2
    		--79329680(+) AAATTC/TCCCAG 1 -- us2k10--------
    rs1497904641,2
    		--79329686(+) CCCAGG/TAGATT 1 -- us2k10--------
    rs178786971,2
    		C,--79329756(+) AAATAT/CTGTCT 1 -- us2k12Minor allele frequency- C:0.01NS 88
    rs559099501,2
    		C,--79329812(+) AGGCAA/GGGCTG 1 -- us2k12Minor allele frequency- G:0.03WA 120

    HapMap Linkage Disequilibrium report for THBS4 (79287134 - 79379110 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for THBS4: --
    Human Gene Mutation Database (HGMD): THBS4

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing THBS4
    DNA2.0 Custom Variant and Variant Library Synthesis for THBS4

    Disorders / Diseases
    for THBS4 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    THBS4 for disorders           About GeneDecksing

    OMIM gene information: 600715    OMIM disorders: --

    20/25 diseases for THBS4 (see all 25):    About MalaCards
    myocardial infarction    coronary heart disease    mycetoma    synovial sarcoma
    muscular dystrophy    cutaneous t cell lymphoma    wilms tumor    dermatomyositis
    hepatitis b    atherosclerosis    sarcoma    ovarian cancer
    breast carcinoma    colorectal cancer    nephropathy    glioblastoma
    hepatitis    fibrosis    retinitis    adenocarcinoma

    4 Novoseek disease relationships for THBS4 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    coronary artery disease 31.2 1 14674882 (1)
    myocardial infarction 23.7 7 16099885 (1), 14674882 (1), 15131549 (1), 16923428 (1) (see all 5)
    atherosclerosis 0 2 12952849 (1)
    tumors 0 2 15897551 (1), 15302496 (1)

    Genetic Association Database (GAD): THBS4
    Human Genome Epidemiology (HuGE) Navigator: THBS4 (20 documents)

    Export disorders for THBS4 gene to outside databases

    Publications
    for THBS4 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for THBS4 gene, integrated from 9 sources (see all 69):
    (articles sorted by number of sources associating them with THBS4)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of human thrombospondin-4. (PubMed id 7852353)1, 2, 3, 9 Lawler J.... Derick L. (1995)
    2. Replication of the association between the thrombospondin-4 A387P polymorphism and myocardial infarction. (PubMed id 15131549)1, 4, 9 Wessel J....McCarthy J.J. (2004)
    3. Large scale association analysis for identification of genes underlying premature coronary heart disease: cumulative perspective from analysis of 111 candidate genes. (PubMed id 15121769)1, 4, 9 McCarthy J.J....Topol E.J. (2004)
    4. Thrombospondin-4 A387P polymorphism is not associated with coronary artery disease and myocardial infarction in the Chinese Han population. (PubMed id 14674882)1, 4, 9 Zhou X....Gu D. (2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Thrombospondin-2 polymorphism is associated with a reduced risk of premature myocardial infarction. (PubMed id 12482844)1, 4 Boekholdt S.M....Reitsma P.H. (2002)
    7. The evolution of the thrombospondin gene family. (PubMed id 8350346)1, 2 Lawler J.... Smith T.F. (1993)
    8. Thrombospondin-4 and its variants: expression and differential effects on endothelial cells. (PubMed id 12952849)1, 9 Stenina O.I....Plow E.F. (2003)
    9. Mechanism and effect of thrombospondin-4 polymorphisms on neutrophil function. (PubMed id 16099885)1, 9 Pluskota E....Plow E.F. (2005)
    10. Biophysical characterization of the signature domains of thrombospondin-4 and thrombospondin-2. (PubMed id 16246837)1, 9 Misenheimer T.M. and Mosher D.F. (2005)

    External Searches for THBS4 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing THBS4 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7060 HGNC: 11788 AceView: THBS4 Ensembl:ENSG00000113296 euGenes: HUgn7060
    ECgene: THBS4 Kegg: 7060 H-InvDB: THBS4

    Other Databases showing THBS4 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing THBS4 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for THBS4 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for THBS4 Genetics and Cytogenetics in Oncology and Haematology
    SeattleSNPshttp://pga.gs.washington.edu/data/thbs4/

    Intellectual Property
    for THBS4 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for THBS4 gene:
    Search GeneIP for patents involving THBS4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for THBS4 gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Antibodies for THBS4 (Thrombospondin-4)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Recombinant/Natural Proteins for THBS4 (Thrombospondin-4)  
     Browse OriGene Antibodies   OriGene shRNA RFP for THBS4  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for THBS4   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for THBS4  
     Browse OriGene Protein Over-expression Lysates   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for THBS4   OriGene 3'-UTR Clone for THBS4  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for THBS4   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for THBS4  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     Browse OriGene full length recombinant human proteins expressed in human HEK293 cells   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for THBS4   OriGene Custom Protein Services for THBS4  
     OriGene Custom Immunoassay Development  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat THBS4
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing THBS4
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat THBS4
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat THBS4
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat THBS4
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat THBS4
     GenScript Custom Purified and Recombinant Proteins Services for THBS4 GenScript cDNA clones with any tag delivered in your preferred vector for THBS4
     GenScript Custom Assay Services for THBS4 GenScript Custom Superior Antibodies Services for THBS4
     GenScript Custom overexpressing Cell Line Services for THBS4 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in THBS4 promoter
     Search Chromatin IP Primers for THBS4
     RT2 qPCR Primer Assay in human, mouse, rat THBS4
     Search GNC Networks for THBS4
     SABiosciences PCR Arrays including human, mouse, rat THBS4
     Search Tocris compounds for THBS4
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     THBS4 antibodies
     THBS4 proteins
     THBS4 lysates
     Search for Antibodies for THBS4 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for THBS4
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     THBS4 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for THBS4
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for THBS4
     SwitchGear 3'UTR luciferase reporter plasmids for THBS4
     SwitchGear Promoter luciferase reporter plasmids for THBS4
     Search ThermoFisher Antibodies for THBS4
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat THBS4
           
    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2013 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      THBS4 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 100 solr: 1.4