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Aliases for THBS3 Gene

Aliases for THBS3 Gene

  • Thrombospondin 3 2 3 5
  • TSP3 3 4
  • Thrombospondin-3 3

External Ids for THBS3 Gene

Previous GeneCards Identifiers for THBS3 Gene

  • GC01M153043
  • GC01M150906
  • GC01M151943
  • GC01M152382
  • GC01M151979
  • GC01M153432
  • GC01M126528

Summaries for THBS3 Gene

Entrez Gene Summary for THBS3 Gene

  • The protein encoded by this gene belongs to the thrombospondin family. Thrombospondin family members are adhesive glycoproteins that mediate cell-to-cell and cell-to-matrix interactions. This protein forms a pentameric molecule linked by a single disulfide bond. This gene shares a common promoter with metaxin 1. Alternate splicing results in coding and non-coding transcript variants. [provided by RefSeq, Nov 2011]

GeneCards Summary for THBS3 Gene

THBS3 (Thrombospondin 3) is a Protein Coding gene. Diseases associated with THBS3 include Gaucher Disease, Type I. Among its related pathways are RET signaling and Malaria. GO annotations related to this gene include calcium ion binding and heparin binding. An important paralog of this gene is THBS4.

UniProtKB/Swiss-Prot for THBS3 Gene

  • Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Can bind to fibrinogen, fibronectin, laminin and type V collagen.

Gene Wiki entry for THBS3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for THBS3 Gene

Genomics for THBS3 Gene

Regulatory Elements for THBS3 Gene

Enhancers for THBS3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F155242 0.6 ENCODE 61.4 -35.1 -35063 2.9 CREB3L1 YBX1 FEZF1 YY1 ZNF416 ZNF143 ZNF548 ZNF263 SP3 TBX21 KIAA0907 ENSG00000271267 MSTO2P RUSC1-AS1 THBS3 ASH1L PYGO2 LOC101928120 KRTCAP2 GBA
GH01F155222 0.4 ENCODE 52.8 -16.6 -16551 5.9 CREB3L1 ZFP64 DMAP1 YY1 ZNF143 ZNF548 ZNF263 SP3 NFYC TBX21 KIAA0907 ENSG00000271267 MSTO2P THBS3 LOC101928120 PYGO2 GBAP1 ASH1L DPM3 RUSC1-AS1
GH01F154950 1 ENCODE 50.1 +254.5 254452 8.7 PKNOX1 ZFP64 ARID4B SIN3A FOS ZNF263 NFYC REST KAT8 SMARCA4 KIAA0907 ENSG00000271267 MSTO2P THBS3 LOC101928120 PYGO2 RUSC1-AS1 ASH1L-AS1 ASH1L CHRNB2
GH01F154324 1 FANTOM5 ENCODE 50.1 +882.1 882065 5.7 HDGF PKNOX1 CREB3L1 WRNIP1 ZFP64 ARID4B SIN3A ZNF2 YY1 ZNF143 CHTOP LOC101928120 INTS3 THBS3 PYGO2 SLC27A3 RUSC1-AS1 DPM3 ENSG00000272654 ENSG00000238279
GH01F155253 1 ENCODE 48.7 -46.2 -46166 3.6 HDGF PKNOX1 CREB3L1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF766 KIAA0907 ENSG00000271267 THBS3 MSTO2P RUSC1-AS1 GBA KRTCAP2 LOC101928120 DPM3 PYGO2
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around THBS3 on UCSC Golden Path with GeneCards custom track

Promoters for THBS3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001524958 -20 1601 HDGF PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF207 SP3
ENSR00001750400 1280 201 DPF2 MNT ZIC2 OSR2 GLIS2 CTBP1 POLR2A GLIS1 FOS

Genomic Location for THBS3 Gene

Chromosome:
1
Start:
155,195,584 bp from pter
End:
155,209,180 bp from pter
Size:
13,597 bases
Orientation:
Minus strand

Genomic View for THBS3 Gene

Genes around THBS3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
THBS3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for THBS3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for THBS3 Gene

Proteins for THBS3 Gene

  • Protein details for THBS3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P49746-TSP3_HUMAN
    Recommended name:
    Thrombospondin-3
    Protein Accession:
    P49746
    Secondary Accessions:
    • B1AVR8
    • B4DQ20
    • Q8WV34

    Protein attributes for THBS3 Gene

    Size:
    956 amino acids
    Molecular mass:
    104201 Da
    Quaternary structure:
    • Oligomer; disulfide-linked.

    Alternative splice isoforms for THBS3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for THBS3 Gene

Post-translational modifications for THBS3 Gene

  • Glycosylation at Asn 310, Asn 407, Asn 644, and Asn 937
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cloud-Clone Corp. Antibodies for THBS3

No data available for DME Specific Peptides for THBS3 Gene

Domains & Families for THBS3 Gene

Suggested Antigen Peptide Sequences for THBS3 Gene

Graphical View of Domain Structure for InterPro Entry

P49746

UniProtKB/Swiss-Prot:

TSP3_HUMAN :
  • Contains 3 EGF-like domains.
  • Belongs to the thrombospondin family.
  • Contains 8 TSP type-3 repeats.
Domain:
  • Contains 3 EGF-like domains.
  • Contains 1 laminin G-like domain.
  • Contains 1 TSP C-terminal (TSPC) domain.
Family:
  • Belongs to the thrombospondin family.
Similarity:
  • Contains 8 TSP type-3 repeats.
genes like me logo Genes that share domains with THBS3: view

No data available for Gene Families for THBS3 Gene

Function for THBS3 Gene

Molecular function for THBS3 Gene

GENATLAS Biochemistry:
thrombospondin III,glycoprotein expressed in lung,cell adhesion molecule
UniProtKB/Swiss-Prot Function:
Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Can bind to fibrinogen, fibronectin, laminin and type V collagen.

Gene Ontology (GO) - Molecular Function for THBS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IEA,NAS 7558000
GO:0008201 heparin binding IEA,IDA 8288588
genes like me logo Genes that share ontologies with THBS3: view
genes like me logo Genes that share phenotypes with THBS3: view

Animal Models for THBS3 Gene

MGI Knock Outs for THBS3:

Animal Model Products

  • Taconic Biosciences Mouse Models for THBS3

miRNA for THBS3 Gene

miRTarBase miRNAs that target THBS3

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for THBS3 Gene

Localization for THBS3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for THBS3 Gene COMPARTMENTS Subcellular localization image for THBS3 gene
Compartment Confidence
extracellular 5
cytosol 2
nucleus 2
lysosome 1
plasma membrane 1
vacuole 1

Gene Ontology (GO) - Cellular Components for THBS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA,TAS --
GO:0048471 perinuclear region of cytoplasm IDA 11943589
genes like me logo Genes that share ontologies with THBS3: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for THBS3 Gene

Pathways & Interactions for THBS3 Gene

genes like me logo Genes that share pathways with THBS3: view

Pathways by source for THBS3 Gene

2 BioSystems pathways for THBS3 Gene
2 Reactome pathways for THBS3 Gene

Gene Ontology (GO) - Biological Process for THBS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003417 growth plate cartilage development IEA --
GO:0007155 cell adhesion IEA --
GO:0007160 cell-matrix adhesion NAS 7558000
GO:0043931 ossification involved in bone maturation IEA --
GO:0060346 bone trabecula formation IEA --
genes like me logo Genes that share ontologies with THBS3: view

No data available for SIGNOR curated interactions for THBS3 Gene

Drugs & Compounds for THBS3 Gene

(1) Drugs for THBS3 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with THBS3: view

Transcripts for THBS3 Gene

Unigene Clusters for THBS3 Gene

Thrombospondin 3:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for THBS3 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c · 4d ^ 5a · 5b · 5c · 5d ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^
SP1: - - - -
SP2: - - - - - - - - - -
SP3: - - - - - - - - - - - -
SP4: - - - - -
SP5:
SP6: -
SP7: - - - - - - -
SP8: - - - - -
SP9: - -
SP10: - - -
SP11:
SP12:
SP13: - -
SP14: -
SP15:
SP16:
SP17:
SP18:

ExUns: 11 ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15a · 15b ^ 16a · 16b ^ 17a · 17b · 17c · 17d ^ 18 ^ 19a · 19b ^ 20a · 20b ^ 21 ^ 22a · 22b · 22c ^ 23 ^ 24a · 24b ·
SP1: - - - - - - -
SP2:
SP3:
SP4:
SP5: -
SP6:
SP7:
SP8:
SP9:
SP10:
SP11: -
SP12:
SP13:
SP14:
SP15: -
SP16:
SP17: -
SP18:

ExUns: 24c ^ 25a · 25b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:

Relevant External Links for THBS3 Gene

GeneLoc Exon Structure for
THBS3
ECgene alternative splicing isoforms for
THBS3

Expression for THBS3 Gene

mRNA expression in normal human tissues for THBS3 Gene

Protein differential expression in normal tissues from HIPED for THBS3 Gene

This gene is overexpressed in Synovial fluid (14.1), Uterus (11.8), Testis (7.7), and Plasma (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for THBS3 Gene



NURSA nuclear receptor signaling pathways regulating expression of THBS3 Gene:

THBS3

SOURCE GeneReport for Unigene cluster for THBS3 Gene:

Hs.169875
genes like me logo Genes that share expression patterns with THBS3: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for THBS3 Gene

Orthologs for THBS3 Gene

This gene was present in the common ancestor of animals.

Orthologs for THBS3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia THBS3 34 35
  • 99.9 (n)
dog
(Canis familiaris)
Mammalia cfa-mir-92b 35
  • 98 (a)
OneToOne
THBS3 34
  • 92.36 (n)
oppossum
(Monodelphis domestica)
Mammalia THBS3 35
  • 94 (a)
OneToOne
cow
(Bos Taurus)
Mammalia THBS3 34 35
  • 92.4 (n)
mouse
(Mus musculus)
Mammalia Thbs3 34 16 35
  • 90.1 (n)
rat
(Rattus norvegicus)
Mammalia LOC681309 34
  • 89.16 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia THBS3 35
  • 89 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia THBS3 35
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia thbs3 34
  • 74.36 (n)
African clawed frog
(Xenopus laevis)
Amphibia thbs3-prov 34
zebrafish
(Danio rerio)
Actinopterygii thbs3a 34 35
  • 68.2 (n)
thbs3b 35
  • 68 (a)
OneToMany
thbs3 34
fruit fly
(Drosophila melanogaster)
Insecta Tsp 36 35
  • 53 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 58 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5547 34
Species where no ortholog for THBS3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for THBS3 Gene

ENSEMBL:
Gene Tree for THBS3 (if available)
TreeFam:
Gene Tree for THBS3 (if available)

Paralogs for THBS3 Gene

Paralogs for THBS3 Gene

(5) SIMAP similar genes for THBS3 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with THBS3: view

Variants for THBS3 Gene

Sequence variations from dbSNP and Humsavar for THBS3 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
VAR_035808 A breast cancer sample
rs193920931 Uncertain significance 155,201,094(-) AAACA(G/T)GTGCA intron-variant, nc-transcript-variant, downstream-variant-500B, reference, missense
rs1058155 -- 155,197,130(-) CGACT(C/G)CTGTG intron-variant, nc-transcript-variant, upstream-variant-2KB, reference, synonymous-codon
rs1058189 -- 155,195,765(-) GAGGT(C/T)TAAGC nc-transcript-variant, downstream-variant-500B, upstream-variant-2KB, utr-variant-3-prime
rs1058195 -- 155,195,730(-) CCCTT(C/T)TCTGG nc-transcript-variant, downstream-variant-500B, upstream-variant-2KB, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for THBS3 Gene

Variant ID Type Subtype PubMed ID
dgv3n68 CNV loss 17160897
esv2758971 CNV gain 17122850
esv2764209 CNV gain+loss 21179565
nsv1010146 CNV gain 25217958
nsv2988 CNV insertion 18451855
nsv464084 CNV loss 19166990
nsv470741 CNV loss 18288195
nsv527682 CNV gain 19592680
nsv547961 CNV loss 21841781

Variation tolerance for THBS3 Gene

Residual Variation Intolerance Score: 2.89% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.74; 78.83% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for THBS3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
THBS3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for THBS3 Gene

Disorders for THBS3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for THBS3 Gene - From: DISEASES and Novoseek

Disorder Aliases PubMed IDs
gaucher disease, type i
  • gaucher's disease
- elite association - COSMIC cancer census association via MalaCards
Search THBS3 in MalaCards View complete list of genes associated with diseases

Relevant External Links for THBS3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
THBS3
genes like me logo Genes that share disorders with THBS3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for THBS3 Gene

Publications for THBS3 Gene

  1. Structure and organization of the human thrombospondin 3 gene (THBS3). (PMID: 7558000) Adolph K.W. … Bornstein P. (Genomics 1995) 3 4 22 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. Corneal stromal cells (keratocytes) express thrombospondins 2 and 3 in wound repair phenotype. (PMID: 11943589) Armstrong D.J. … Kaye S. (Int. J. Biochem. Cell Biol. 2002) 3 22 64
  4. Relative abundance of thrombospondin 2 and thrombospondin 3 mRNAs in human tissues. (PMID: 10329465) Adolph K.W. (Biochem. Biophys. Res. Commun. 1999) 3 22 64
  5. The human thrombospondin 3 gene: analysis of transcription initiation and an alternatively spliced transcript. (PMID: 10527891) Adolph K.W. … Bornstein P. (Mol. Cell Biol. Res. Commun. 1999) 3 22 64

Products for THBS3 Gene

Sources for THBS3 Gene

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