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Aliases for THBS3 Gene

Aliases for THBS3 Gene

  • Thrombospondin 3 2 3
  • TSP3 3 4 6
  • Thrombospondin-3 3

External Ids for THBS3 Gene

Summaries for THBS3 Gene

Entrez Gene Summary for THBS3 Gene

  • The protein encoded by this gene belongs to the thrombospondin family. Thrombospondin family members are adhesive glycoproteins that mediate cell-to-cell and cell-to-matrix interactions. This protein forms a pentameric molecule linked by a single disulfide bond. This gene shares a common promoter with metaxin 1. Alternate splicing results in coding and non-coding transcript variants. [provided by RefSeq, Nov 2011]

GeneCards Summary for THBS3 Gene

THBS3 (Thrombospondin 3) is a Protein Coding gene. Diseases associated with THBS3 include pseudoachondroplasia. Among its related pathways are PI3K-Akt signaling pathway and Signaling by FGFR. GO annotations related to this gene include calcium ion binding and heparin binding. An important paralog of this gene is THBS4.

UniProtKB/Swiss-Prot for THBS3 Gene

  • Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Can bind to fibrinogen, fibronectin, laminin and type V collagen

Gene Wiki entry for THBS3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for THBS3 Gene

Genomics for THBS3 Gene

Genomic Location for THBS3 Gene

Start:
155,195,588 bp from pter
End:
155,209,051 bp from pter
Size:
13,464 bases
Orientation:
Minus strand

Genomic View for THBS3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for THBS3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for THBS3 Gene

Regulatory Elements for THBS3 Gene

Transcription factor binding sites by QIAGEN in the THBS3 gene promoter:

Proteins for THBS3 Gene

  • Protein details for THBS3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P49746-TSP3_HUMAN
    Recommended name:
    Thrombospondin-3
    Protein Accession:
    P49746
    Secondary Accessions:
    • B1AVR8
    • B4DQ20
    • Q8WV34

    Protein attributes for THBS3 Gene

    Size:
    956 amino acids
    Molecular mass:
    104201 Da
    Quaternary structure:
    • Oligomer; disulfide-linked

    Alternative splice isoforms for THBS3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for THBS3 Gene

Proteomics data for THBS3 Gene at MOPED

Post-translational modifications for THBS3 Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn310, Asn407, Asn644, and Asn937

Other Protein References for THBS3 Gene

No data available for DME Specific Peptides for THBS3 Gene

Domains for THBS3 Gene

UniProtKB/Swiss-Prot:

TSP3_HUMAN
Domain:
  • Contains 3 EGF-like domains.:
    • P49746
  • Contains 1 laminin G-like domain.:
    • P49746
  • Contains 1 TSP C-terminal (TSPC) domain.:
    • P49746
Family:
  • Belongs to the thrombospondin family.:
    • P49746
Similarity:
  • Contains 8 TSP type-3 repeats.:
    • P49746
genes like me logo Genes that share domains with THBS3: view

No data available for Gene Families for THBS3 Gene

Function for THBS3 Gene

Molecular function for THBS3 Gene

GENATLAS Biochemistry: thrombospondin III,glycoprotein expressed in lung,cell adhesion molecule
UniProtKB/Swiss-Prot Function: Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Can bind to fibrinogen, fibronectin, laminin and type V collagen

Gene Ontology (GO) - Molecular Function for THBS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding NAS 7558000
GO:0005515 protein binding --
GO:0008201 heparin binding IDA 8288588
genes like me logo Genes that share ontologies with THBS3: view

Phenotypes for THBS3 Gene

genes like me logo Genes that share phenotypes with THBS3: view

Animal Models for THBS3 Gene

MGI Knock Outs for THBS3:

miRNA for THBS3 Gene

miRTarBase miRNAs that target THBS3

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for THBS3 Gene

Localization for THBS3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for THBS3 Gene COMPARTMENTS Subcellular localization image for THBS3 gene
Compartment Confidence
extracellular 4
cytosol 1
lysosome 1
nucleus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for THBS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0048471 perinuclear region of cytoplasm IDA 11943589
genes like me logo Genes that share ontologies with THBS3: view

Pathways for THBS3 Gene

genes like me logo Genes that share pathways with THBS3: view

Pathways by source for THBS3 Gene

2 BioSystems pathways for THBS3 Gene
2 Reactome pathways for THBS3 Gene

Gene Ontology (GO) - Biological Process for THBS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003417 growth plate cartilage development IEA --
GO:0007155 cell adhesion --
GO:0007160 cell-matrix adhesion NAS 7558000
GO:0043931 ossification involved in bone maturation IEA --
GO:0060346 bone trabecula formation IEA --
genes like me logo Genes that share ontologies with THBS3: view

Compounds for THBS3 Gene

(1) Novoseek inferred chemical compound relationships for THBS3 Gene

Compound -log(P) Hits PubMed IDs
calcium 0 2
genes like me logo Genes that share compounds with THBS3: view

Transcripts for THBS3 Gene

Unigene Clusters for THBS3 Gene

Thrombospondin 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for THBS3 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c · 4d ^ 5a · 5b · 5c · 5d ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^
SP1: - - - -
SP2: - - - - - - - - - -
SP3: - - - - - - - - - - - -
SP4: - - - - -
SP5:
SP6: -
SP7: - - - - - - -
SP8: - - - - -
SP9: - -
SP10: - - -
SP11:
SP12:
SP13: - -
SP14: -
SP15:
SP16:
SP17:
SP18:

ExUns: 11 ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15a · 15b ^ 16a · 16b ^ 17a · 17b · 17c · 17d ^ 18 ^ 19a · 19b ^ 20a · 20b ^ 21 ^ 22a · 22b · 22c ^ 23 ^ 24a · 24b ·
SP1: - - - - - - -
SP2:
SP3:
SP4:
SP5: -
SP6:
SP7:
SP8:
SP9:
SP10:
SP11: -
SP12:
SP13:
SP14:
SP15: -
SP16:
SP17: -
SP18:

ExUns: 24c ^ 25a · 25b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:

Relevant External Links for THBS3 Gene

GeneLoc Exon Structure for
THBS3
ECgene alternative splicing isoforms for
THBS3

Expression for THBS3 Gene

mRNA expression in normal human tissues for THBS3 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for THBS3 Gene

SOURCE GeneReport for Unigene cluster for THBS3 Gene Hs.169875

genes like me logo Genes that share expressions with THBS3: view

Orthologs for THBS3 Gene

This gene was present in the common ancestor of animals.

Orthologs for THBS3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia THBS3 36
  • 99.9 (n)
  • 99.9 (a)
THBS3 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia THBS3 36
  • 92.4 (n)
  • 97.38 (a)
THBS3 37
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-92b 37
  • 98 (a)
OneToOne
THBS3 36
  • 92.36 (n)
  • 97.59 (a)
mouse
(Mus musculus)
Mammalia Thbs3 36
  • 90.1 (n)
  • 97.18 (a)
Thbs3 16
Thbs3 37
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia THBS3 37
  • 94 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia THBS3 37
  • 89 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC681309 36
  • 89.16 (n)
  • 96.71 (a)
lizard
(Anolis carolinensis)
Reptilia THBS3 37
  • 73 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia thbs3-prov 36
tropical clawed frog
(Silurana tropicalis)
Amphibia thbs3 36
  • 74.36 (n)
  • 80.43 (a)
zebrafish
(Danio rerio)
Actinopterygii thbs3 36
thbs3a 36
  • 68.2 (n)
  • 70.6 (a)
thbs3a 37
  • 69 (a)
OneToMany
thbs3b 37
  • 68 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Tsp 37
  • 37 (a)
OneToMany
Tsp 38
  • 53 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5547 36
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 58 (a)
OneToMany
Species with no ortholog for THBS3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for THBS3 Gene

ENSEMBL:
Gene Tree for THBS3 (if available)
TreeFam:
Gene Tree for THBS3 (if available)

Paralogs for THBS3 Gene

Paralogs for THBS3 Gene

Selected SIMAP similar genes for THBS3 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with THBS3: view

Variants for THBS3 Gene

Sequence variations from dbSNP and Humsavar for THBS3 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs370545 -- 155,205,599(-) GGTTT(C/T)GCCAT intron-variant, upstream-variant-2KB
rs406141 -- 155,202,386(-) CTGAC(A/C)CCTGT missense, reference, nc-transcript-variant
rs423144 -- 155,199,564(-) GTTGG(A/C)CAGGC intron-variant
rs914615 -- 155,206,101(+) CCCTA(A/G)TGGAG intron-variant, upstream-variant-2KB
rs1058155 -- 155,197,130(-) CGACT(C/G)CTGTG synonymous-codon, reference, nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for THBS3 Gene

Variant ID Type Subtype PubMed ID
nsv464084 CNV Loss 19166990
dgv3n68 CNV Loss 17160897
dgv132e1 CNV Complex 17122850
nsv470741 CNV Loss 18288195
nsv872457 CNV Loss 21882294
nsv872458 CNV Loss 21882294
dgv390n71 CNV Loss 21882294
nsv527682 CNV Gain 19592680
nsv2988 CNV Insertion 18451855
dgv391n71 CNV Loss 21882294

Relevant External Links for THBS3 Gene

HapMap Linkage Disequilibrium report
THBS3

Disorders for THBS3 Gene

(1) MalaCards Diseases for THBS3 Gene

Search for THBS3 Gene in MalaCards »

(1) University of Copenhagen DISEASES for THBS3 Gene

(1) Novoseek inferred disease relationships for THBS3 Gene

Disease -log(P) Hits PubMed IDs
gaucher disease 55 1
genes like me logo Genes that share disorders with THBS3: view

No data available for UniProtKB/Swiss-Prot for THBS3 Gene

Publications for THBS3 Gene

  1. Structure and organization of the human thrombospondin 3 gene (THBS3). (PMID: 7558000) Adolph K.W. … Bornstein P. (Genomics 1995) 3 4 23
  2. Identification of three additional genes contiguous to the glucocerebrosidase locus on chromosome 1q21: implications for Gaucher disease. (PMID: 9331372) Winfield S.L. … Sidransky E. (Genome Res. 1997) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Relative abundance of thrombospondin 2 and thrombospondin 3 mRNAs in human tissues. (PMID: 10329465) Adolph K.W. (Biochem. Biophys. Res. Commun. 1999) 3 23
  5. The human thrombospondin 3 gene: analysis of transcription initiation and an alternatively spliced transcript. (PMID: 10527891) Adolph K.W. … Bornstein P. (Mol. Cell Biol. Res. Commun. 1999) 3 23

Products for THBS3 Gene

Sources for THBS3 Gene

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