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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

THBS3 Gene

protein-coding   GIFtS: 60
GCID: GC01M155165

thrombospondin 3
 Explore 8 diseases affiliated with
THBS3 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for THBS3    

Aliases
for THBS3 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Thrombospondin 31 2
TSP32 3 5
Thrombospondin-31

External Ids:    HGNC: 117871   Entrez Gene: 70592   Ensembl: ENSG000001692317   OMIM: 1880625   UniProtKB: P497463   

Export aliases for THBS3 gene to outside databases

Previous GC identifers: GC01M153043 GC01M150906 GC01M151943 GC01M152382 GC01M151979 GC01M153432 GC01M126528


Summaries
for THBS3 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for THBS3:
The protein encoded by this gene belongs to the thrombospondin family. Thrombospondin family members are adhesive
glycoproteins that mediate cell-to-cell and cell-to-matrix interactions. This protein forms a pentameric molecule
linked by a single disulfide bond. This gene shares a common promoter with metaxin 1. Alternate splicing results in
coding and non-coding transcript variants. (provided by RefSeq, Nov 2011)

UniProtKB/Swiss-Prot: TSP3_HUMAN, P49746
Function: Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Can bind to fibrinogen,
fibronectin, laminin and type V collagen

Gene Wiki entry for THBS3


Genomic Views
for THBS3 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_004487.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the THBS3 gene promoter:
         ATF-2   c-Jun   YY1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: THBS3 promoter sequence
   Search SABiosciences Chromatin IP Primers for THBS3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat THBS3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q21   Ensembl cytogenetic band:  1q22   HGNC cytogenetic band: 1q21

THBS3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
THBS3 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M155165:  view genomic region     (about GC identifiers)

Start:
 155,165,379 bp from pter      End:
 155,178,842 bp from pter
Size:
 13,464 bases      Orientation:
 minus strand

Proteins
for THBS3 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: TSP3_HUMAN, P49746 (See protein sequence)
Recommended Name: Thrombospondin-3 precursor  
Size: 956 amino acids; 104201 Da
Subunit: Oligomer; disulfide-linked
Secondary accessions: B1AVR8 B4DQ20 Q8WV34
Alternative splicing: 2 isoforms:  P49746-1   P49746-2   

Explore the universe of human proteins at neXtProt for THBS3: NX_P49746

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P49746

    • THBS3 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (3 alternative transcripts): 
    NP_001239536.1  NP_001239537.1  NP_009043.1  

    ENSEMBL proteins: 
     ENSP00000357362   ENSP00000392207   ENSP00000437353   ENSP00000444792   ENSP00000404040  
    Reactome Protein details: P49746
    Human Recombinant Protein Products: 
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    OriGene Protein Over-expression Lysate: THBS3
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    Novus Biologicals THBS3 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for THBS3

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0048471perinuclear region of cytoplasm IDA11943589


    THBS3 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for THBS3

    Protein Domains /
    Families
    for THBS3 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    THBS3 for domains           About GeneDecksing

    5/11 InterPro domains/families (see all 11):
     IPR001881 EGF-like_Ca-bd
     IPR000742 EG-like_dom
     IPR013320 ConA-like_subgrp
     IPR001791 Laminin_G
     IPR013032 EGF-like_CS

    Graphical View of Domain Structure for InterPro Entry P49746

    ProtoNet protein and cluster: P49746

    3 Blocks protein families:
    IPB001881 EGF-like calcium-binding
    IPB003129 Thrombospondin
    IPB008859 Thrombospondin


    UniProtKB/Swiss-Prot: TSP3_HUMAN, P49746
    Similarity: Belongs to the thrombospondin family
    Similarity: Contains 3 EGF-like domains
    Similarity: Contains 1 laminin G-like domain
    Similarity: Contains 1 TSP C-terminal (TSPC) domain
    Similarity: Contains 8 TSP type-3 repeats


    Function
    for THBS3 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: TSP3_HUMAN, P49746
    Function: Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Can bind to fibrinogen,
    fibronectin, laminin and type V collagen

         Genatlas biochemistry entry for THBS3:
    thrombospondin III,glycoprotein expressed in lung,cell adhesion molecule

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat THBS3
    7 QIAGEN miScript miRNA Assays for microRNAs that regulate THBS3:
    hsa-miR-3184 hsa-miR-185* hsa-miR-519e hsa-miR-1182 hsa-miR-515-3p hsa-miR-570 hsa-miR-423-5p
    SwitchGear 3'UTR luciferase reporter plasmid: THBS3 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for THBS3 (see all 4)
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    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for THBS3

    Clone
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    Search LifeMap BioReagents cell lines for THBS3

    In Situ Assay
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    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005509calcium ion binding NAS7558000
    GO:0005515protein binding ----
    GO:0008201heparin binding IDA8288588


    THBS3 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for THBS3:
     Increased gamma-H2AX phosphory 

    Animal Models:
         Mouse knock-out Thbs3tm1Bst for THBS3
         3 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Thbs3):
     growth/size  limbs/digits/tail  skeleton 

    THBS3 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for THBS3 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/8 super-pathways (see all 8) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Focal Adhesion
    		Focal Adhesion1.00
    		Focal adhesion0.66
    2Inflammatory Response Pathway
    		Inflammatory Response Pathway1.00
    3Malaria
    		Malaria1.00
    4ECM-receptor interaction
    		ECM-receptor interaction1.00
    5Phagosome
    		Phagosome1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    2 BioSystems Pathways for THBS3 
        Focal Adhesion
    Inflammatory Response Pathway

    2        Reactome Pathways for THBS3
        Signal Transduction
    Signaling by PDGF


    5         Kegg Pathways  (Kegg details for THBS3):
        Phagosome
    TGF-beta signaling pathway
    Focal adhesion
    ECM-receptor interaction
    Malaria


    THBS3 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for THBS3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/32 Interacting proteins for THBS3 (P497463 ENSP000003573624) via UniProtKB, MINT, STRING, and/or I2D (see all 32)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    THBS2P354423, ENSP000003557514I2D: score=2 STRING: ENSP00000355751
    THBS1ENSP000002603564STRING: ENSP00000260356
    THBS4ENSP000003397304STRING: ENSP00000339730
    FURINENSP000002681714STRING: ENSP00000268171
    PDGFBENSP000003303824STRING: ENSP00000330382
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003417growth plate cartilage development IEA--
    GO:0007155cell adhesion ----
    GO:0007160cell-matrix adhesion NAS7558000
    GO:0043931ossification involved in bone maturation IEA--
    GO:0060346bone trabecula formation IEA--


    THBS3 for ontologies           About GeneDecksing



    Drugs & Compounds
    for THBS3 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    THBS3 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for THBS3
    1 Novoseek chemical compound relationship for THBS3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    calcium 0 2 10753957 (2)

    Search CenterWatch for drugs/clinical trials and news about THBS3 / TSP3 

    Transcripts
    for THBS3 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for THBS3 gene (3 alternative transcripts): 
    NM_001252607.1  NM_001252608.1  NM_007112.4  

    Unigene Cluster for THBS3:

    Thrombospondin 3
    Hs.169875  [show with all ESTs]
    Unigene Representative Sequence: NM_007112
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000498500 ENST00000487250 ENST00000368378(uc021pat.1 uc001fix.3 uc009wqi.3 uc001fiy.3 uc010pfu.2)
    ENST00000469769 ENST00000465596 ENST00000486260(uc001fja.2 uc009wqj.1)
    ENST00000496332 ENST00000460050 ENST00000457183 ENST00000541990 ENST00000541576
    ENST00000428962(uc010pfv.2)

    miRNA
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    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat THBS3
    7 QIAGEN miScript miRNA Assays for microRNAs that regulate THBS3:
    hsa-miR-3184 hsa-miR-185* hsa-miR-519e hsa-miR-1182 hsa-miR-515-3p hsa-miR-570 hsa-miR-423-5p
    SwitchGear 3'UTR luciferase reporter plasmid: THBS3 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for THBS3 (see all 4)
    OriGene shRNA RFP: THBS3
    OriGene siRNA: THBS3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat THBS3
    Clone
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    GenScript: all cDNA clones in your preferred vector: THBS3 (NM_007112)
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat THBS3
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat THBS3

    Additional cDNA sequence: 

    AK074796.1 AK223278.1 AK298592.1 AK298914.1 AK314337.1 BC018786.1 BC113846.1 BC113847.1 
    L38969.1 NR_045553.1 

    22 DOTS entries:

    DT.216188  DT.91922420  DT.100041902  DT.100724418  DT.40132697  DT.91649978  DT.92033193  DT.95080465 
    DT.95080493  DT.100785595  DT.447970  DT.91982569  DT.100675232  DT.121449578  DT.40117162  DT.91866301 
    DT.95145298  DT.100879437  DT.121449584  DT.121449681  DT.216190  DT.99974671 

    24/162 AceView cDNA sequences (see all 162):

    BQ876660 BM909409 NM_007112 BQ044953 BM784089 BM709575 BQ005702 CB162257 
    AA774044 CN483167 BM746952 BC018786 BX115945 BM783620 BU633241 BM746462 
    CF125986 BM743042 BM742311 BQ772917 BM753035 AK074796 BU733588 BM772093 

    GeneLoc Exon Structure

    5/18 Alternative Splicing Database (ASD) splice patterns (SP) for THBS3 (see all 18)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c · 4d ^ 5a · 5b · 5c · 5d ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^
    SP1:                                      -     -                             -                                               -                                 
    SP2:                                      -     -                             -     -     -     -     -     -     -           -                                 
    SP3:                                      -     -                             -     -     -     -     -     -     -           -     -           -               
    SP4:                                      -     -           -     -           -                                                                                 
    SP5:                                                                                                                                                            

    ExUns: 11 ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15a · 15b ^ 16a · 16b ^ 17a · 17b · 17c · 17d ^ 18 ^ 19a · 19b ^ 20a · 20b ^ 21 ^ 22a · 22b · 22c ^ 23 ^ 24a · 24b ·
    SP1:        -                                   -           -     -     -           -                                                                 -         
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                -                                                                           

    ExUns: 24c ^ 25a · 25b
    SP1:                  
    SP2:                  
    SP3:                  
    SP4:                  
    SP5:                  


    ECgene alternative splicing isoforms for THBS3

    Expression
    for THBS3 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    THBS3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CGAGGGGGGC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    THBS3 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    2 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Neural TubeNeural TubeSpinal Neural Tube CellsNeural Ectoderm
    Spinal CordPresumptive Spinal CordSpinal Cord
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Posterior foregut-like cells (A scalable, suspensi...)

    See THBS3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for THBS3

    SOURCE GeneReport for Unigene cluster: Hs.169875
        SABiosciences Expression via Pathway-Focused PCR Array including THBS3: 
              Extracellular Matrix & Adhesion Molecules in human mouse rat

    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat THBS3
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for THBS3

    Orthologs
    for THBS3 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for THBS3 gene from 4/17 species (see all 17)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    lizard
    (Anolis carolinensis)    		 Reptilia THBS36
    		 --
    		 75(a)
    		 1 ↔ 1
    		 GL344370.1(23359-42243)
    African clawed frog
    (Xenopus laevis)    		 Amphibia thbs3-prov2 thrombospondin 3 76.98(n)    BC048222.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii thbs32 thrombospondin 3 76.43(n)   252849  AF462310.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Tsp3 cell adhesion molecule 53(a)     --


    ENSEMBL Gene Tree for THBS3 (if available)
    TreeFam Gene Tree for THBS3 (if available) 

    Paralogs
    for THBS3 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for THBS3 gene
    THBS12  THBS42  COMP2  THBS22  
    5 SIMAP similar genes for THBS3 using alignment to 6 protein entries:     TSP3_HUMAN (see all proteins):
    THBS4    COMP    DKFZp686G02190    THBS1    THBS2

    THBS3 for paralogs           About GeneDecksing



    Genomic Variants
    for THBS3 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/205 NCBI SNPs in THBS3 are shown (see all 205)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 1 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1813596201,2
    		--155165242(+) TCCCCA/CACCCG 5 -- ds50010--------
    rs1459504931,2
    		--155165291(+) TTCCAC/TCCTCC 5 -- ds50010--------
    rs1856519851,2
    		--155165318(+) CTCGCC/TGATTC 5 -- ds50010--------
    rs1394720271,2
    		--155165351(+) CGGAAA/GATCCC 5 -- ds50010--------
    rs1911958911,2
    		--155165401(+) CTTTAC/TGGCAA 5 -- ut31 nc-transcript-variantds50010--------
    rs1825736611,2
    		--155165519(+) AGCCAA/GAGAAG 5 -- ds5001 nc-transcript-variantut310--------
    rs10581891,2
    		C--155165556(-) GAGGTC/TTAAGC 5 -- ut31 nc-transcript-variantds5001 ese33Minor allele frequency- T:0.00MN NA 188
    rs1890783351,2
    		C,--155165672(+) GCTCAA/GAGTCC 7 S F mis10--------
    rs1404690441,2
    		C,F--155165843(+) CAAGAC/TGCCCC 7 H R mis12Minor allele frequency- T:0.00NA EU 5855
    rs1465914431,2
    		C,--155165884(+) GAATCC/TGCCAC 7 A nc-transcript-variantsyn11Minor allele frequency- T:0.00NA 4552

    HapMap Linkage Disequilibrium report for THBS3 (155165379 - 155178842 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for THBS3
         2 CNVs: 3315 4257

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing THBS3
    DNA2.0 Custom Variant and Variant Library Synthesis for THBS3

    Disorders / Diseases
    for THBS3 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    THBS3 for disorders           About GeneDecksing

    OMIM gene information: 188062    OMIM disorders: --

    8 diseases for THBS3:    About MalaCards
    gaucher's disease    pseudoachondroplasia    osteosarcoma    lung cancer
    breast cancer    retinitis    malaria    neuronitis

    3 diseases from the University of Copenhagen DISEASES database for THBS3:
    Pseudoachondroplasia     Gaucher's disease     Echinococcosis

    1 Novoseek disease relationship for THBS3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gaucher disease 55 1 7558000 (1)


    Export disorders for THBS3 gene to outside databases

    Publications
    for THBS3 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for THBS3 gene, integrated from 9 sources (see all 36):
    (articles sorted by number of sources associating them with THBS3)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Structure and organization of the human thrombospondin 3 gene (THBS3). (PubMed id 7558000)1, 2, 9 Adolph K.W.... Bornstein P. (1995)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Identification of three additional genes contiguous to the glucocerebrosidase locus on chromosome 1q21: implications for Gaucher disease. (PubMed id 9331372)1, 2 Winfield S.L.... Sidransky E. (1997)
    4. Thrombospondin 3 (Thbs3), a new member of the thrombospondin gene family. (PubMed id 1601886)1, 3 Vos H.L....Bornstein P. (1992)
    5. The human thrombospondin 3 gene: analysis of transcription initiation and an alternatively spliced transcript. (PubMed id 10527891)1, 9 Adolph K.W. and Bornstein P. (1999)
    6. Corneal stromal cells (keratocytes) express thrombospondins 2 and 3 in wound repair phenotype. (PubMed id 11943589)1, 9 Armstrong D.J....Kaye S. (2002)
    7. Thrombospondin 3 is a pentameric molecule held together by interchain disulfide linkage involving two cysteine residues. (PubMed id 7759526)1, 9 Qabar A....Dixit V. (1995)
    8. Relative abundance of thrombospondin 2 and thrombospondin 3 mRNAs in human tissues. (PubMed id 10329465)1, 9 Adolph K.W. (1999)
    9. Effects of THBS3, SPARC and SPP1 expression on biological behavior and survival in patients with osteosarcoma. (PubMed id 17022822)1 Dalla-Torre C.A....Squire J.A. (2006)
    10. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)

    External Searches for THBS3 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing THBS3 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7059 HGNC: 11787 AceView: THBS3 Ensembl:ENSG00000169231 euGenes: HUgn7059
    ECgene: THBS3 Kegg: 7059 H-InvDB: THBS3

    Other Databases showing THBS3 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing THBS3 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for THBS3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for THBS3 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for THBS3 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for THBS3 gene:
    Search GeneIP for patents involving THBS3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

     
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