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Aliases for THBS3 Gene

Aliases for THBS3 Gene

  • Thrombospondin 3 2 3 5
  • TSP3 3 4

External Ids for THBS3 Gene

Previous GeneCards Identifiers for THBS3 Gene

  • GC01M153043
  • GC01M150906
  • GC01M151943
  • GC01M152382
  • GC01M151979
  • GC01M153432
  • GC01M126528

Summaries for THBS3 Gene

Entrez Gene Summary for THBS3 Gene

  • The protein encoded by this gene belongs to the thrombospondin family. Thrombospondin family members are adhesive glycoproteins that mediate cell-to-cell and cell-to-matrix interactions. This protein forms a pentameric molecule linked by a single disulfide bond. This gene shares a common promoter with metaxin 1. Alternate splicing results in coding and non-coding transcript variants. [provided by RefSeq, Nov 2011]

GeneCards Summary for THBS3 Gene

THBS3 (Thrombospondin 3) is a Protein Coding gene. Among its related pathways are Malaria and PI3K-Akt signaling pathway. GO annotations related to this gene include calcium ion binding and heparin binding. An important paralog of this gene is THBS4.

UniProtKB/Swiss-Prot for THBS3 Gene

  • Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Can bind to fibrinogen, fibronectin, laminin and type V collagen.

Gene Wiki entry for THBS3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for THBS3 Gene

Genomics for THBS3 Gene

Regulatory Elements for THBS3 Gene

Enhancers for THBS3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around THBS3 on UCSC Golden Path with GeneCards custom track

Promoters for THBS3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around THBS3 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the THBS3 gene promoter:

Genomic Location for THBS3 Gene

Chromosome:
1
Start:
155,195,584 bp from pter
End:
155,209,180 bp from pter
Size:
13,597 bases
Orientation:
Minus strand

Genomic View for THBS3 Gene

Genes around THBS3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
THBS3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for THBS3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for THBS3 Gene

Proteins for THBS3 Gene

  • Protein details for THBS3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P49746-TSP3_HUMAN
    Recommended name:
    Thrombospondin-3
    Protein Accession:
    P49746
    Secondary Accessions:
    • B1AVR8
    • B4DQ20
    • Q8WV34

    Protein attributes for THBS3 Gene

    Size:
    956 amino acids
    Molecular mass:
    104201 Da
    Quaternary structure:
    • Oligomer; disulfide-linked.

    Alternative splice isoforms for THBS3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for THBS3 Gene

Proteomics data for THBS3 Gene at MOPED

Post-translational modifications for THBS3 Gene

  • Glycosylation at Asn 310, Asn 407, Asn 644, and Asn 937
  • Modification sites at PhosphoSitePlus

Other Protein References for THBS3 Gene

No data available for DME Specific Peptides for THBS3 Gene

Domains & Families for THBS3 Gene

Suggested Antigen Peptide Sequences for THBS3 Gene

Graphical View of Domain Structure for InterPro Entry

P49746

UniProtKB/Swiss-Prot:

TSP3_HUMAN :
  • Contains 3 EGF-like domains.
  • Belongs to the thrombospondin family.
  • Contains 8 TSP type-3 repeats.
Domain:
  • Contains 3 EGF-like domains.
  • Contains 1 laminin G-like domain.
  • Contains 1 TSP C-terminal (TSPC) domain.
Family:
  • Belongs to the thrombospondin family.
Similarity:
  • Contains 8 TSP type-3 repeats.
genes like me logo Genes that share domains with THBS3: view

No data available for Gene Families for THBS3 Gene

Function for THBS3 Gene

Molecular function for THBS3 Gene

GENATLAS Biochemistry:
thrombospondin III,glycoprotein expressed in lung,cell adhesion molecule
UniProtKB/Swiss-Prot Function:
Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Can bind to fibrinogen, fibronectin, laminin and type V collagen.
genes like me logo Genes that share phenotypes with THBS3: view

Animal Models for THBS3 Gene

MGI Knock Outs for THBS3:

Animal Model Products

  • Taconic Biosciences Mouse Models for THBS3

miRNA for THBS3 Gene

miRTarBase miRNAs that target THBS3

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for THBS3 Gene

Localization for THBS3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for THBS3 Gene COMPARTMENTS Subcellular localization image for THBS3 gene
Compartment Confidence
extracellular 5
cytosol 2
nucleus 2
lysosome 1
plasma membrane 1
vacuole 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for THBS3 Gene

Pathways & Interactions for THBS3 Gene

genes like me logo Genes that share pathways with THBS3: view

Pathways by source for THBS3 Gene

2 BioSystems pathways for THBS3 Gene
2 Reactome pathways for THBS3 Gene

Gene Ontology (GO) - Biological Process for THBS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion IEA --
GO:0007160 cell-matrix adhesion NAS 7558000
genes like me logo Genes that share ontologies with THBS3: view

No data available for SIGNOR curated interactions for THBS3 Gene

Drugs & Compounds for THBS3 Gene

(1) Drugs for THBS3 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with THBS3: view

Transcripts for THBS3 Gene

Unigene Clusters for THBS3 Gene

Thrombospondin 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for THBS3 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c · 4d ^ 5a · 5b · 5c · 5d ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^
SP1: - - - -
SP2: - - - - - - - - - -
SP3: - - - - - - - - - - - -
SP4: - - - - -
SP5:
SP6: -
SP7: - - - - - - -
SP8: - - - - -
SP9: - -
SP10: - - -
SP11:
SP12:
SP13: - -
SP14: -
SP15:
SP16:
SP17:
SP18:

ExUns: 11 ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15a · 15b ^ 16a · 16b ^ 17a · 17b · 17c · 17d ^ 18 ^ 19a · 19b ^ 20a · 20b ^ 21 ^ 22a · 22b · 22c ^ 23 ^ 24a · 24b ·
SP1: - - - - - - -
SP2:
SP3:
SP4:
SP5: -
SP6:
SP7:
SP8:
SP9:
SP10:
SP11: -
SP12:
SP13:
SP14:
SP15: -
SP16:
SP17: -
SP18:

ExUns: 24c ^ 25a · 25b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:

Relevant External Links for THBS3 Gene

GeneLoc Exon Structure for
THBS3
ECgene alternative splicing isoforms for
THBS3

Expression for THBS3 Gene

mRNA expression in normal human tissues for THBS3 Gene

Protein differential expression in normal tissues from HIPED for THBS3 Gene

This gene is overexpressed in Synovial fluid (14.1), Uterus (11.8), Testis (7.7), and Plasma (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for THBS3 Gene



SOURCE GeneReport for Unigene cluster for THBS3 Gene Hs.169875

genes like me logo Genes that share expression patterns with THBS3: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for THBS3 Gene

Orthologs for THBS3 Gene

This gene was present in the common ancestor of animals.

Orthologs for THBS3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia THBS3 35
  • 92.4 (n)
  • 97.38 (a)
THBS3 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia THBS3 35
  • 92.36 (n)
  • 97.59 (a)
cfa-mir-92b 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Thbs3 35
  • 90.1 (n)
  • 97.18 (a)
Thbs3 16
Thbs3 36
  • 97 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia THBS3 35
  • 99.9 (n)
  • 99.9 (a)
THBS3 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC681309 35
  • 89.16 (n)
  • 96.71 (a)
oppossum
(Monodelphis domestica)
Mammalia THBS3 36
  • 94 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia THBS3 36
  • 89 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia THBS3 36
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia thbs3 35
  • 74.36 (n)
  • 80.43 (a)
African clawed frog
(Xenopus laevis)
Amphibia thbs3-prov 35
zebrafish
(Danio rerio)
Actinopterygii thbs3 35
thbs3a 35
  • 68.2 (n)
  • 70.6 (a)
thbs3a 36
  • 69 (a)
OneToMany
thbs3b 36
  • 68 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Tsp 37
  • 53 (a)
Tsp 36
  • 37 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5547 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 58 (a)
OneToMany
Species with no ortholog for THBS3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for THBS3 Gene

ENSEMBL:
Gene Tree for THBS3 (if available)
TreeFam:
Gene Tree for THBS3 (if available)

Paralogs for THBS3 Gene

(5) SIMAP similar genes for THBS3 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with THBS3: view

Variants for THBS3 Gene

Sequence variations from dbSNP and Humsavar for THBS3 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
VAR_035808 A breast cancer sample
rs35154152 - 155,202,934(-) ACTGC(A/G)GCCCC nc-transcript-variant, reference, missense
rs370545 -- 155,205,599(-) GGTTT(C/T)GCCAT intron-variant
rs914615 -- 155,206,101(+) CCCTA(A/G)TGGAG intron-variant
rs2361529 -- 155,203,032(+) AGCCA(A/T)TGGTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for THBS3 Gene

Variant ID Type Subtype PubMed ID
nsv464084 CNV Loss 19166990
dgv3n68 CNV Loss 17160897
dgv132e1 CNV Complex 17122850
nsv470741 CNV Loss 18288195
nsv872457 CNV Loss 21882294
nsv872458 CNV Loss 21882294
dgv390n71 CNV Loss 21882294
nsv527682 CNV Gain 19592680
nsv2988 CNV Insertion 18451855
dgv391n71 CNV Loss 21882294

Variation tolerance for THBS3 Gene

Residual Variation Intolerance Score: 2.89% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.74; 78.83% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for THBS3 Gene

Disorders for THBS3 Gene

Relevant External Links for THBS3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
THBS3

No disorders were found for THBS3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for THBS3 Gene

Publications for THBS3 Gene

  1. Structure and organization of the human thrombospondin 3 gene (THBS3). (PMID: 7558000) Adolph K.W. … Bornstein P. (Genomics 1995) 3 4 23 67
  2. Corneal stromal cells (keratocytes) express thrombospondins 2 and 3 in wound repair phenotype. (PMID: 11943589) Armstrong D.J. … Kaye S. (Int. J. Biochem. Cell Biol. 2002) 3 23
  3. Relative abundance of thrombospondin 2 and thrombospondin 3 mRNAs in human tissues. (PMID: 10329465) Adolph K.W. (Biochem. Biophys. Res. Commun. 1999) 3 23
  4. The human thrombospondin 3 gene: analysis of transcription initiation and an alternatively spliced transcript. (PMID: 10527891) Adolph K.W. … Bornstein P. (Mol. Cell Biol. Res. Commun. 1999) 3 23
  5. Thrombospondin 3 is a pentameric molecule held together by interchain disulfide linkage involving two cysteine residues. (PMID: 7759526) Qabar A. … Dixit V. (J. Biol. Chem. 1995) 3 23

Products for THBS3 Gene

Sources for THBS3 Gene

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