Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

THBS2 Gene

protein-coding GIFtS: 64
GCID: GC06M169615

thrombospondin 2

Explore 50 diseases affiliated with
THBS2 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Thrombospondin 2¹ ²
TSP2¹ ² ³
Thrombospondin-2¹

External Ids:	HGNC: 11786¹	Entrez Gene: 7058²	Ensembl: ENSG00000186340⁷	OMIM: 188061⁵	UniProtKB: P35442³

Export aliases for THBS2 gene to outside databases

Previous GC identifers: GC06U990123 GC06M9S0210 GC06M169433 GC06M167041

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for THBS2:

The protein encoded by this gene belongs to the thrombospondin family. It is a disulfide-linked homotrimeric

glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. This protein has been shown to function as a

potent inhibitor of tumor growth and angiogenesis. Studies of the mouse counterpart suggest that this protein may

modulate the cell surface properties of mesenchymal cells and be involved in cell adhesion and migration. (provided by

RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: TSP2_HUMAN, P35442

Function: Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Ligand for CD36 mediating

antiangiogenic properties

Gene Wiki entry for THBS2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000006.11 NC_018917.1 NT_025741.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the THBS2 gene promoter:
MyoD Nkx2-5
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: THBS2 promoter sequence

Search SABiosciences Chromatin IP Primers for THBS2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat THBS2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q27 Ensembl cytogenetic band: 6q27 HGNC cytogenetic band: 6q27

THBS2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
THBS2 gene location

GeneLoc information about chromosome 6 GeneLoc Exon Structure

GeneLoc location for GC06M169615: view genomic region (about GC identifiers)

Start:	169,615,875 bp from pter	End:	169,654,139 bp from pter
Size:	38,265 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: TSP2_HUMAN, P35442 (See protein sequence)

Recommended Name: Thrombospondin-2 precursor

Size: 1172 amino acids; 129991 Da

Subunit: Homotrimer; disulfide-linked. Interacts (via the TSP type I repeats) with CD36; the interaction conveys an

antiangiogenic effect. Interacts (via the TSP type I repeats) with HRG; the interaction blocks the antiangiogenic

effect of THBS2 with CD36 (By similarity). Can bind to fibrinogen, fibronectin, laminin and type V collagen

2 PDB 3D structures from and Proteopedia for THBS2:

1YO8 (3D)

2RHP (3D)

Secondary accessions: A6H8N1 A7E232 Q5RI52

Explore the universe of human proteins at neXtProt for THBS2: NX_P35442

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P35442

THBS2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_003238.2

ENSEMBL proteins:

ENSP00000355751 ENSP00000398928

Reactome Protein details: P35442
Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	R&D Systems Recombinant & Natural Proteins for THBS2 (Thrombospondin-2)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate: THBS2 OriGene Custom Protein Services for THBS2
	GenScript Custom Purified and Recombinant Proteins Services for THBS2
	Novus Biologicals THBS2 Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for THBS2

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	TAS	--
GO:0005604	basement membrane	IEA	--
GO:0031012	extracellular matrix	--	--

THBS2 for ontologies About GeneDecksing

THBS2 Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of THBS2
	R&D Systems Antibodies for THBS2 (Thrombospondin-2)
	Browse OriGene Antibodies OriGene Custom Antibody Services for THBS2
	GenScript Custom Superior Antibodies Services for THBS2
	Novus Biologicals THBS2 Antibodies
	Search for Antibodies for THBS2 at Abcam
	Uscn Antibodies for THBS2
	Search ThermoFisher Antibodies for THBS2

Assay Products for THBS2:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	R&D Systems ELISAs for THBS2 (Thrombospondin-2) (see all)
	GenScript Custom Assay Services for THBS2
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for THBS2

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

THBS2 for domains About GeneDecksing

5/13 InterPro domains/families (see all 13):

IPR000884 Thrombospondin_1_rpt

IPR001881 EGF-like_Ca-bd

IPR000742 EG-like_dom

IPR013320 ConA-like_subgrp

IPR001791 Laminin_G

Graphical View of Domain Structure for InterPro Entry P35442

ProtoNet protein and cluster: P35442

5/6 Blocks protein families (see all 6):

IPB000884 Thrombospondin

IPB001007 von Willebrand factor

IPB001881 EGF-like calcium-binding

IPB006210 Type I EGF

IPB008085 Thrombospondin type 1 repeat signature

UniProtKB/Swiss-Prot: TSP2_HUMAN, P35442

Similarity: Belongs to the thrombospondin family

Similarity: Contains 2 EGF-like domains

Similarity: Contains 1 laminin G-like domain

Similarity: Contains 1 TSP C-terminal (TSPC) domain

Similarity: Contains 3 TSP type-1 domains

Similarity: Contains 8 TSP type-3 repeats

Similarity: Contains 1 VWFC domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: TSP2_HUMAN, P35442

Function: Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Ligand for CD36 mediating

antiangiogenic properties

Genatlas biochemistry entry for THBS2:

thrombospondin II,extracellular,glycoprotein expressed in smooth muscle,fibroblast in cell adhesion molecule

miRNA Products:		OriGene 3'-UTR Clone: THBS2 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat THBS2
		8/35 QIAGEN miScript miRNA Assays for microRNAs that regulate THBS2 (see all 35):
		hsa-miR-582-3p hsa-miR-3938 hsa-miR-30d hsa-miR-9 hsa-miR-124 hsa-miR-30a hsa-miR-506 hsa-miR-181b

		SwitchGear 3'UTR luciferase reporter plasmid: THBS2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for THBS2 (see all 4) OriGene shRNA RFP: THBS2 OriGene siRNA: THBS2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat THBS2

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for THBS2

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for THBS2 (see all 2) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for THBS2 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: THBS2 (NM_003247)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for THBS2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat THBS2

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for THBS2
		LifeMap BioReagents: cell line associated with THBS2: PureStem 4D20.8, NCr-fac Progenitor

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for THBS2

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005509	calcium ion binding	IEA	--
GO:0005515	protein binding	IPI	19818485
GO:0008201	heparin binding	IEA	--

THBS2 for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for THBS2:

Decreased number of cells in m

Animal Models:
Mouse knock-out Thbs2^tm1Bst for THBS2
13 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Thbs2):

behavior/neurological	cardiovascular system	cellular	hematopoietic system	homeostasis/metabolism
immune system	integument	limbs/digits/tail	mortality/aging	muscle
respiratory system	skeleton	tumorigenesis

THBS2 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/8 super-pathways (see all 8) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Focal Adhesion

Focal Adhesion

1.00

Focal adhesion

0.66

Malaria

Malaria

1.00

ECM-receptor interaction

ECM-receptor interaction

1.00

Phagosome

Phagosome

1.00

TGF-beta signaling pathway

TGF-beta signaling pathway

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for THBS2

Inhibition of Matrix Metalloproteinases

1 BioSystems Pathway for THBS2

Focal Adhesion

2 Reactome Pathways for THBS2

	Signal Transduction
	Signaling by PDGF

5 Kegg Pathways (Kegg details for THBS2):

	Phagosome
	TGF-beta signaling pathway
	Focal adhesion
	ECM-receptor interaction
	Malaria

THBS2 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for THBS2

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/37 Interacting proteins for THBS2 (P35442^{1, 3} ENSP00000355751⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 37)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
MMP2	P08253³, ENSP00000219070⁴	I2D: score=2 STRING: ENSP00000219070
THBS3	P49746³, ENSP00000357362⁴	I2D: score=2 STRING: ENSP00000357362
MMP9	P14780³, ENSP00000361405⁴	I2D: score=3 STRING: ENSP00000361405
ITGA4	ENSP00000380227⁴	STRING: ENSP00000380227
ITGA6	ENSP00000386896⁴	STRING: ENSP00000386896

About this table

Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007155	cell adhesion	IEA	--
GO:0016525	negative regulation of angiogenesis	IDA	--
GO:0051965	positive regulation of synapse assembly	--	--

THBS2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

THBS2 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for THBS2
10/12 Novoseek chemical compound relationships for THBS2 gene (see all 12) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
cerivastatin	45.4	1	12605021 (1)
tgf beta1	40.9	4	15347840 (3), 9016857 (1)
procollagen	38	1	1426766 (1)
vegf	32.5	20	16365183 (6), 10448307 (2), 17107379 (2), 10821491 (1) (see all 5)
acth	17.6	3	10342868 (2), 12358136 (1)
oligonucleotide	12.7	1	11563036 (1)
ganciclovir	10.8	1	10950755 (1)
heparin	9.04	2	8663244 (1), 1459996 (1)
thymidine	0	3	9016857 (1), 11723011 (1)
calcium	0	12	16246837 (5), 17620335 (3), 7798222 (1), 18682400 (1)

Search CenterWatch for drugs/clinical trials and news about THBS2 / TSP2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for THBS2 gene:

NM_003247.2

Unigene Cluster for THBS2:

Thrombospondin 2

Hs.371147 [show with all ESTs]

Unigene Representative Sequence: NM_003247

5 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000366787(uc003qwt.3) ENST00000488355 ENST00000461848 ENST00000472733

ENST00000435791

miRNA Products:		OriGene 3'-UTR Clone: THBS2 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat THBS2
		8/35 QIAGEN miScript miRNA Assays for microRNAs that regulate THBS2 (see all 35):
		hsa-miR-582-3p hsa-miR-3938 hsa-miR-30d hsa-miR-9 hsa-miR-124 hsa-miR-30a hsa-miR-506 hsa-miR-181b

		SwitchGear 3'UTR luciferase reporter plasmid: THBS2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for THBS2 (see all 4) OriGene shRNA RFP: THBS2 OriGene siRNA: THBS2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat THBS2

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for THBS2 (see all 2) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for THBS2 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: THBS2 (NM_003247)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for THBS2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat THBS2

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for THBS2 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat THBS2
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat THBS2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat THBS2

Additional cDNA sequence:

AK292429.1 BC127845.1 BC146676.1 BC150175.1 BX641023.1 L12350.1 M81339.1

14 DOTS entries:

DT.318423 DT.86854901 DT.97858822 DT.95261122 DT.100792529 DT.86837324 DT.97858821 DT.100792527

DT.100792528 DT.100792531 DT.121351011 DT.40224336 DT.75150060 DT.95149447

24/320 AceView cDNA sequences (see all 320):

AI750269 BU627598 H88241 CN483550 C00154 AW581293 CA431209 CB267812

AA962069 C21348 AI753153 AA953039 CK000113 AA344029 CA414667 NM_003247

BU728348 AI130835 BX641023 AI753719 AI580302 AL603377 BU736223 CA446830

GeneLoc Exon Structure

5/7 Alternative Splicing Database (ASD) splice patterns (SP) for THBS2 (see all 7) About this scheme

ExUns:	1a	·	1b	^	2	^	3	^	4	^	5a	·	5b	^	6a	·	6b	^	7a	·	7b	·	7c	^	8a	·	8b	^	9	^	10	^	11	^	12	^	13a	·	13b	^	14a	·	14b	^	15	^	16	^	17	^	18	^
SP1:							-		-		-																-										-						-
SP2:							-		-		-
SP3:									-		-
SP4:											-
SP5:

ExUns:	19	^	20	^	21	^	22	^	23	^	24	^	25	^	26
SP1:
SP2:
SP3:
SP4:
SP5:

ECgene alternative splicing isoforms for THBS2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

THBS2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCAGACTCAG

About this image

THBS2 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

8 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Bone

Stylopod Epiphyseal End

Prechondrocytes

Selective marker (cell-identifying gene)

Bone, Cartilage

Bone

Autopod Epiphyseal End

Prechondrocytes

Bone, Cartilage

Bone

Zeugopod Epiphyseal End

Prechondrocytes

Bone, Cartilage

Limb

Autopod

Mesenchymal Condensate Cells

Bone, Cartilage

Limb

Stylopod

Mesenchymal Condensate Cells

Bone, Cartilage

Limb

Zeugopod

Mesenchymal Condensate Cells

Bone, Cartilage

Heart

Atrioventricular Node

Atrioventricular Node Cells

Myocardium

Kidney

Interstitial Stroma

Kidney

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 10 LifeMap Cells

Name

Category

Sclerotome cells (Primary Cell)

Bone, Cartilage, Somite

PureStem™ progenitor E68 (Embryonic Progenitor Cell)

PureStem™ progenitor T42 (Embryonic Progenitor Cell)

PureStem™ mesenchymal Progenitor SK11 (Embryonic Progenitor Cell)

Adipose, Bone, Cartilage

PureStem™ mesenchymal progenitor 4D20.8 (Embryonic Progenitor Cell)

Lateral Plate Mesoderm, Neural Crest

PureStem™ mesenchymal progenitor E15 (Embryonic Progenitor Cell)

Adipose, Bone, Cartilage

PureStem™ progenitor E69 (Embryonic Progenitor Cell)

PureStem™ progenitor T36 (Embryonic Progenitor Cell)

ES04(HES-4) (Embryonic Stem Cell)

Early Embryo, Inner Cell Mass

Line H9 (WA09) (Embryonic Stem Cell)

Early Embryo, Inner Cell Mass

See THBS2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for THBS2

SOURCE GeneReport for Unigene cluster: Hs.371147

UniProtKB/Swiss-Prot: TSP2_HUMAN, P35442

Tissue specificity: High expression in invertebral disk tissue

SABiosciences Expression via Pathway-Focused PCR Arrays including THBS2:

Lung Cancer in human mouse rat

Fibrosis in human mouse rat

Extracellular Matrix & Adhesion Molecules in human mouse rat

Angiogenesis in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for THBS2 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat THBS2
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat THBS2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat THBS2

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for THBS2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for THBS2 gene from 3/16 species (see all 16) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	THBS2¹	thrombospondin 2	73.58(n) 79.59(a)		414837 NM_001001755.1 NP_001001755.1
lizard (Anolis carolinensis)	Reptilia	THBS2⁶	--	79(a)	1 ↔ 1	1(223967288-224015624)
zebrafish (Danio rerio)	Actinopterygii	thbs2a¹	thrombospondin 2a	70.07(n) 72.03(a)		794881 XM_001919813.3 XP_001919848.3

ENSEMBL Gene Tree for THBS2 (if available)
TreeFam Gene Tree for THBS2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for THBS2 gene

THBS1² THBS4² COMP² THBS3²

5 SIMAP similar genes for THBS2 using alignment to 2 protein entries: TSP2_HUMAN (see all proteins):

DKFZp686G02190 THBS3 COMP THBS4 THBS1

THBS2 for paralogs About GeneDecksing

1 Pseudogenes.org Pseudogene for THBS2
PGOHUM00000258302

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 6 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs73238277^1,2	C,	--	169615401(+)	`GCCCGA/GTCGGC`	1	--	ds500¹		2		WA	120
rs59728197^1,2	C,	--	169615416(+)	`TTTTAG/AGCAGT`	1	--	ds500¹		4		WA NA EA	360
rs190689635^1,2		--	169615457(+)	`GGTCCG/TCTACT`	1	--	ds500¹		0	--	--	--	--
rs141048362^1,2		--	169615509(+)	`CAGCTC/TGTATT`	1	--	ds500¹		0	--	--	--	--
rs146875953^1,2		--	169615599(+)	`CCCTCA/GTTTGA`	1	--	ds500¹		0	--	--	--	--
rs139397620^1,2		--	169615612(+)	`ATGAGC/TAGAGG`	1	--	ds500¹		0	--	--	--	--
rs142692504^1,2		--	169615631(+)	`ATGAAC/TTGCTA`	1	--	ds500¹		0	--	--	--	--
rs72566887^1,2	F,	--	169615655(+)	`CACACC/TGTGCT`	1	--	ds500¹		1		EA	120
rs77150007^1,2	C,F,	--	169615656(+)	`ACACCG/ATGCTG`	1	--	ds500¹		1		NA	120
rs200471612^1,2		--	169615821(+)	`ACCCC-/TTTCCC`	1	--	ds500¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for THBS2 (169615875 - 169654139 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 10 variations for THBS2
5 CNVs: 81771 94253 64725 94256 94255
5 Indels: 62601 81773 94254 47060 81772
Human Gene Mutation Database (HGMD): THBS2

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing THBS2

DNA2.0 Custom Variant and Variant Library Synthesis for THBS2

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

THBS2 for disorders           About GeneDecksing

OMIM gene information: 188061
OMIM disorders: 603932
UniProtKB/Swiss-Prot: TSP2_HUMAN, P35442

Genetic variations in THBS2 may be a cause of susceptibility to intervertebral disk disease (IDD)

[MIM:603932]; also known as lumbar disk herniation (LDH). IDD is one of the most common musculo-skeletal disorders and

the predominant cause of low-back pain and unilateral leg pain

20/50 diseases for THBS2 (see all 50): About MalaCards

lumbar disc herniation ehlers-danlos syndrome posterior uveal melanoma thoracic aortic aneurysm

pre-eclampsia back pain type 2 diabetes mellitus aortic aneurysm

uterine fibroid gingival overgrowth myocardial infarction malignant glioma

cytomegalovirus infection coronary heart disease diabetes mellitus malignant mesothelioma

herpes simplex endometrial cancer eclampsia cervical cancer

10/23 Novoseek disease relationships for THBS2 gene (see all 23) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
neovascularization	36.8	1	19578767 (1)
carcinoma lewis lung	32.3	1	11929817 (1)
collagen fibril	29.6	1	12781637 (1)
tumors	29	59	18955754 (6), 10611308 (4), 11929817 (3), 11712798 (3) (see all 20)
carcinoma squamous cell	21.4	6	11929817 (1), 11147670 (1), 14675207 (1), 10611308 (1)
melanoma	20.7	9	12353704 (3), 19082472 (3), 11929817 (1), 9032471 (1) (see all 5)
glioma	18.9	8	10448307 (4), 17919663 (1), 11132930 (1)
metastasis	18.7	14	9888480 (3), 18720079 (2), 12353704 (2), 19082472 (2) (see all 5)
cancer	18.6	3	11147670 (1), 18955754 (1)
breast carcinoma	14.6	4	9012463 (2), 9032471 (1)

Genetic Association Database (GAD): THBS2
Human Genome Epidemiology (HuGE) Navigator: THBS2 (17 documents)

Export disorders for THBS2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for THBS2 gene, integrated from 9 sources (see all 172):
(articles sorted by number of sources associating them with THBS2)

Utopia: connect your pdf to the dynamic
world of online information

A functional polymorphism in THBS2 that affects alternative splicing and MMP binding is associated with lumbar-disc herniation. (PubMed id 18455130)^{1, 2, 3} Hirose Y....Ikegawa S. (2008)
Large scale association analysis for identification of genes underlying premature coronary heart disease: cumulative perspective from analysis of 111 candidate genes. (PubMed id 15121769)^{1, 4, 9} McCarthy J.J....Topol E.J. (2004)
Structure of the calcium-rich signature domain of human thrombospondin-2. (PubMed id 16186819)^{1, 2, 9} Carlson C.B.... Keck J.L. (2005)
Thrombospondin-2 polymorphism is associated with a reduced risk of premature myocardial infarction. (PubMed id 12482844)^{1, 4, 9} Boekholdt S.M....Reitsma P.H. (2002)
Disulfide connectivity of recombinant C-terminal region of human thrombospondin 2. (PubMed id 11590138)^{1, 2, 9} Misenheimer T.M.... Mosher D.F. (2001)
Sequence and characterization of the complete human thrombospondin 2 cDNA: potential regulatory role for the 3' untranslated region. (PubMed id 8406456)^{1, 2, 9} Labell T.L. and Byers P.H. (1993)
Thrombospondin II: partial cDNA sequence, chromosome location, and expression of a second member of the thrombospondin gene family in humans. (PubMed id 1559694)^{1, 2} Labell T.L.... Byers P.H. (1992)
Microvessel density and CpG island methylation of the THBS2 gene in malignant ovarian tumors. (PubMed id 18955754)^{1, 9} Czekierdowski A....Kotarski J. (2008)
Thrombospondin 2 regulates cell proliferation induced by Rac1 redox-dependent signaling. (PubMed id 12861025)^{1, 9} Lopes N....Kovacic H. (2003)
Biophysical characterization of the signature domains of thrombospondin-4 and thrombospondin-2. (PubMed id 16246837)^{1, 9} Misenheimer T.M. and Mosher D.F. (2005)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 7058	HGNC: 11786	AceView: THBS2	Ensembl:ENSG00000186340	euGenes: HUgn7058
ECgene: THBS2	Kegg: 7058	H-InvDB: THBS2

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for THBS2	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for THBS2	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for THBS2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for THBS2 gene:
Search GeneIP for patents involving THBS2

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section

	Browse Small Molecules at EMD Millipore
	Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
	Browse for Gene Knock-down Tools from EMD Millipore
	Browse Kits and Assays available from EMD Millipore
	EMD Millipore Mono- and Polyclonal Antibodies for the study of THBS2
	Browse Purified and Recombinant Proteins at EMD Millipore

	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Antibodies for THBS2 (Thrombospondin-2)		Browse Cell Culture Products
	ELISAs for THBS2 (Thrombospondin-2)		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Multiplex/Array Assay Kits/Reagents for THBS2 (Thrombospondin-2)
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Phosphatase Activity Assays/Reagents		Recombinant/Natural Proteins for THBS2 (Thrombospondin-2)

	Browse OriGene Antibodies		OriGene shRNA RFP for THBS2
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for THBS2		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for THBS2
	OriGene Protein Over-expression Lysate for THBS2		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for THBS2		OriGene 3'-UTR Clone for THBS2
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for THBS2		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for THBS2
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for THBS2		OriGene Custom Protein Services for THBS2
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat THBS2
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing THBS2
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat THBS2
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat THBS2
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat THBS2
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat THBS2

	GenScript Custom Purified and Recombinant Proteins Services for THBS2		GenScript cDNA clones with any tag delivered in your preferred vector for THBS2
	GenScript Custom Assay Services for THBS2		GenScript Custom Superior Antibodies Services for THBS2
	GenScript Custom overexpressing Cell Line Services for THBS2		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in THBS2 promoter
	Search Chromatin IP Primers for THBS2
	RT² qPCR Primer Assay in human, mouse, rat THBS2
	GNC Network for THBS2
	SABiosciences PCR Arrays including human, mouse, rat THBS2

Search Tocris compounds for THBS2

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological cDNA Clones
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	THBS2 antibodies
	THBS2 lysates

	Search for Antibodies for THBS2 at Abcam
	See all of Abcam's Antibodies, Kits and Proteins for THBS2
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

THBS2 Proteins, Antibodies, CLIAs, and ELISAs

Cell Line associated with THBS2: PureStem 4D20.8, NCr-fac Progenitor

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for THBS2

	SwitchGear 3'UTR luciferase reporter plasmids for THBS2
	SwitchGear Promoter luciferase reporter plasmids for THBS2

Search ThermoFisher Antibodies for THBS2

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat THBS2

GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

View Random Gene

Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes THBS2 gene at Home site.

hostname: 356977-web1.xennexinc.com index build: 100 solr: 1.4

Advanced Search

Export list of displayed genes

THBS2 Gene

thrombospondin 2

Aliases
for THBS2 gene

Summaries
for THBS2 gene

Genomic Views
for THBS2 gene

Proteins
for THBS2 gene

Protein Domains /
Families
for THBS2 gene

Function
for THBS2 gene

Pathways & Interactions
for THBS2 gene

Drugs & Compounds
for THBS2 gene

Transcripts
for THBS2 gene

Expression
for THBS2 gene

Orthologs
for THBS2 gene

Paralogs
for THBS2 gene

Genomic Variants
for THBS2 gene

Disorders / Diseases
for THBS2 gene

Publications
for THBS2 gene

External Searches for THBS2 gene

Genome Databases showing THBS2 gene

Other Databases showing THBS2 gene

Specialized Databases showing THBS2 gene

Intellectual Property
for THBS2 gene

Products
for THBS2 gene

View Random Gene

Melanoma
BREAST CARCINOMA
Colon Cancer
Ovarian Cancer
Glioma
Colorectal Cancer
Adenoma
Inflammation
Carcinoma
Carcinoma Squamous Cell
Cervical Cancer
Neovascularization
Tumors
Metastasis
Adenocarcinoma
Necrosis
Cancer
Cancer Lung
Collagen fibril
Endometrial Cancer
Malignant Glioma
Carcinoma Lewis Lung
Myocardial Infarction

Advanced Search

Export list of displayed genes

THBS2 Gene

thrombospondin 2

Aliasesfor THBS2 gene

Summariesfor THBS2 gene

Genomic Viewsfor THBS2 gene

Proteinsfor THBS2 gene

Protein Domains /Familiesfor THBS2 gene

Functionfor THBS2 gene

Pathways & Interactionsfor THBS2 gene

Drugs & Compoundsfor THBS2 gene

Transcriptsfor THBS2 gene

Expression for THBS2 gene

Orthologsfor THBS2 gene

Paralogsfor THBS2 gene

Genomic Variantsfor THBS2 gene

Disorders / Diseasesfor THBS2 gene

Publicationsfor THBS2 gene

External Searches for THBS2 gene

Genome Databases showing THBS2 gene

Other Databases showing THBS2 gene

Specialized Databases showing THBS2 gene

Intellectual Propertyfor THBS2 gene

Productsfor THBS2 gene

View Random Gene

Aliases
for THBS2 gene

Summaries
for THBS2 gene

Genomic Views
for THBS2 gene

Proteins
for THBS2 gene

Protein Domains /
Families
for THBS2 gene

Function
for THBS2 gene

Pathways & Interactions
for THBS2 gene

Drugs & Compounds
for THBS2 gene

Transcripts
for THBS2 gene

Expression
for THBS2 gene

Orthologs
for THBS2 gene

Paralogs
for THBS2 gene

Genomic Variants
for THBS2 gene

Disorders / Diseases
for THBS2 gene

Publications
for THBS2 gene

Intellectual Property
for THBS2 gene

Products
for THBS2 gene