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THBS2 Gene

protein-coding GIFtS: 66

GC06M169433

thrombospondin 2
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
OTTHUMP00000042899 ^²
TSP2 ^¹, ², ³

Descriptions
thrombospondin 2 ^²

External Ids
HGNC: 11786¹
Entrez Gene: 7058²
UniProtKB: P35442³
Ensembl: ENSG00000186340⁷

Search outside databases for aliases for THBS2 gene

Previous GC identifers: GC06U990123 GC06M9S0210

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for THBS2:

The protein encoded by this gene belongs to the thrombospondin family. It is a disulfide-linked

homotrimeric glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. This protein

has been shown to function as a potent inhibitor of tumor growth and angiogenesis. Studies of the

mouse counterpart suggest that this protein may modulate the cell surface properties of

mesenchymal cells and be involved in cell adhesion and migration. [provided by RefSeq]

UniProtKB/Swiss-Prot: TSP2_HUMAN, P35442

Function: Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Can

bind to fibrinogen, fibronectin, laminin and type V collagen

Gene Wiki entry for THBS2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the THBS2 gene

Entrez Gene cytogenetic band: 6q27 Ensembl cytogenetic band: 6q27 HGNC cytogenetic band: 6q27

THBS2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 6 GeneLoc Exon Structure

GeneLoc location for GC06M169433: (about GC identifiers)

Start:	169,357,800 bp from pter
End:	169,396,062 bp from pter
Size:	38,263 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000006.10 NT_007302.13

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: TSP2_HUMAN, P35442 (See protein sequence)

Recommended Name: Thrombospondin-2 precursor

Size: 1172 amino acids; 129991 Da

Subunit: Homotrimer; disulfide-linked

PDB structure from and Proteopedia :

1YO8 (3D)

2RHP (3D)

Secondary accessions: Q5RI52

REFSEQ proteins: NP_003238.2

ENSEMBL proteins:

ENSP00000355751 ENSP00000375948

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	R&D Systems Recombinant & Natural Proteins for THBS2 (Thrombospondin-2)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Thrombospondin 2)
	Browse Abnova for Human Recombinant Proteins

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	IEA	--
GO:0031093	platelet alpha granule lumen	EXP	6338048

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Antibodies for THBS2:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse Antibodies at Sigma-Aldrich
	R&D Systems Antibodies for THBS2 (Thrombospondin-2)
	Antibodies from Abcam (Thrombospondin 2), each with their Abpromise^SM
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Novus Biologicals Antibody for THBS2

Assays for THBS2:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	R&D Systems ELISAs for THBS2 (Thrombospondin-2) (see all)
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P35442

ProtoNet protein and cluster: P35442

5/6 Blocks protein families (see all 6 ):

IPB000884 Thrombospondin

IPB001007 von Willebrand factor

IPB001881 EGF-like calcium-binding

IPB006210 Type I EGF

IPB008085 Thrombospondin type 1 repeat signature

UniProtKB/Swiss-Prot: TSP2_HUMAN, P35442

Similarity: Belongs to the thrombospondin family

Similarity: Contains 3 EGF-like domains

Similarity: Contains 1 TSP C-terminal (TSPC) domain

Similarity: Contains 1 TSP N-terminal (TSPN) domain

Similarity: Contains 3 TSP type-1 domains

Similarity: Contains 8 TSP type-3 repeats

Similarity: Contains 1 VWFC domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (THBS2)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (THBS2)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_003247

Applied Biosystems Silencer® siRNAs for THBS2

Sigma-Aldrich siRNA and siRNA Panels for THBS2

Sigma-Aldrich shRNA Panels and shRNA for THBS2

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_003247
Myc/DDK tagged cDNA clone in CMV expression vector: NM_003247
untagged cDNA clone in CMV expression vector: NM_003247

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_003247

UniProtKB/Swiss-Prot: TSP2_HUMAN, P35442

Function: Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Can

bind to fibrinogen, fibronectin, laminin and type V collagen

Genatlas biochemistry entry for THBS2:

thrombospondin II,extracellular,glycoprotein expressed in smooth muscle,fibroblast in cell adhesion

molecule

14 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Thbs2):

	behavior/neurological	cellular	hematopoietic system	homeostasis/metabolism
immune system	lethality-prenatal/perinatal	life span-post-weaning/aging	limbs/digits/tail	muscle
respiratory system	skeleton	skin/coat/nails	tumorigenesis

4 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005198	structural molecule activity	IEA	--
GO:0005509	calcium ion binding	IEA	--
GO:0005515	protein binding	IEA	--
GO:0008201	heparin binding	TAS	1459996

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Gene Network Central^TM Interacting Genes and Proteins Network for THBS2

5/81 Interacting proteins for THBS2 (ENSP00000355751³) via UniProtKB, MINT, and/or STRING (see all 81 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
MMP2	ENSP00000219070³	STRING (score=.986)
MMP9	ENSP00000361405³	STRING (score=.979)
CD47	ENSP00000355361³	STRING (score=.974)
SPP1	ENSP00000237623³	STRING (score=.967)
THBS3	ENSP00000357362³	STRING (score=.964)

About this table

1 Gene Ontology (GO) biological process term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007155	cell adhesion	IEA	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for THBS2
6 Novoseek chemical compound relationships for THBS2 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
tgf beta1	42.71	4	15347840 (3), 9016857 (1)
procollagen	39.48	1	1426766 (1)
acth	18.89	3	10342868 (2), 12358136 (1)
oligonucleotide	14.17	1	11563036 (1)
calcium	0.00	12	16246837 (5), 17620335 (3), 7798222 (1), 18682400 (1)
thymidine	0.00	3	9016857 (1), 11723011 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (THBS2)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (THBS2)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_003247

Sigma-Aldrich siRNA and siRNA Panels for THBS2

Sigma-Aldrich shRNA Panels and shRNA for THBS2

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_003247

REFSEQ mRNAs for THBS2 gene:

NM_003247.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_003247

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_003247
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_003247
                                 untagged cDNA clone in CMV expression vector: NM_003247

Additional cDNA sequence:

AK292429.1 BC127845.1 BC146676.1 BC150175.1 BX641023.1 L12350.1 M81339.1

14 DOTS entries:

DT.318423 DT.86854901 DT.97858822 DT.95261122 DT.100792529 DT.86837324 DT.97858821 DT.100792527

DT.100792528 DT.100792531 DT.121351011 DT.40224336 DT.95149447 DT.75150060

24/320 AceView cDNA sequences (see all 320 ):

AI753153 BU728348 CA420699 CA414667 CA431209 CB267812 C00154 AL603377

H88241 BQ940133 AA962069 AW581293 BX099356 AA344029 CN483550 BX641023

CK000113 AI580302 BU627598 AI753719 AW068385 CA446830 AI750269 CA449275

highest scoring ESTs for THBS2:

L12350 AI969659 AL603377 AL703695 AA131691 AA137054 AA149811 AA149832 AA149859 AA149866

Unigene Cluster for THBS2:

Thrombospondin 2

Hs.371147 [show with all ESTs]

Unigene Representative Sequence: NM_003247

GeneLoc Exon Structure

5/7 Alternative Splicing Database (ASD) splice patterns (SP) for THBS2 (see all 7 )

ExUns:	1a	·	1b	^	2	^	3	^	4	^	5a	·	5b	^	6a	·	6b	^	7a	·	7b	·	7c	^	8a	·	8b	^	9	^	10	^	11	^	12	^	13a	·	13b	^	14a	·	14b	^	15	^	16	^	17	^	18	^
SP1:							-		-		-																-										-						-
SP2:							-		-		-
SP3:									-		-
SP4:											-
SP5:

ExUns:	19	^	20	^	21	^	22	^	23	^	24	^	25	^	26
SP1:
SP2:
SP3:
SP4:
SP5:

About this scheme

ECgene alternative splicing isoforms for THBS2

2 Ensembl transcripts including schematic representations:

ENST00000366787 ENST00000392099

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

THBS2 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for THBS2

¹ / ² / ³

5 probe-sets matching THBS2 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
43353_at²^{, 3}	U95-B	1	1.00	1.00	0.97	1.33	AI969659	0.80	1.00	0.91	1
658_at²^{, 3}	U95-A	1	1.00	1.00	0.99	0.71	L12350	1.00	1.00	1.00	1
659_g_at²^{, 3}	U95-A	1	1.00	1.00	0.99	0.97	L12350	1.00	1.00	1.00	1
203083_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_003247	0.60	1.00	0.82	1
203083_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks THBS2 for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: GCAGACTCAG

SOURCE GeneReport for Unigene cluster: Hs.371147
Expression variation in blood from EXPOLDB for THBS2
UniProtKB/Swiss-Prot: TSP2_HUMAN, P35442
Tissue specificity: High expression in invertebral disk tissue

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for THBS2 gene from 5/8 species (see all 8 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	THBS2¹	--	thrombospondin 2	85.16(n) 89.98(a)	484087 XM_541204.2 XP_541204.2
cow (Bos taurus)	THBS2¹	--	thrombospondin 2	85.53(n) 90.26(a)	338092 NM_176872.1 NP_789861.1
rat (Rattus norvegicus)	Thbs2¹	--	thrombospondin 2	83.4(n) 88.47(a)	292406 XM_214778.4 XP_214778.2
mouse (Mus musculus)	Thbs2^{1, 5}	17 (8.10 cM)⁵	thrombospondin 2^{1, 5}	83.89(n)¹ 88.56(a)¹	21826¹ NM_011581.1¹ NP_035711.1¹ AK132508⁵ AK142552⁵ (see all 14)
chicken (Gallus gallus)	THBS2¹	--	thrombospondin 2	73.58(n) 79.59(a)	414837 NM_001001755.1 NP_001001755.1

About this table Species with no ortholog for THBS2

ENSEMBL Gene Tree for THBS2

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for THBS2 gene

THBS1²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/377 NCBI SNPs in THBS2 are shown (see all 377 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 138)

AB	SNP ID	Valid	Chr 6 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs1132782^1,2	A,C,F,H	169358348(-)	`TGTCTG/ATCTGA`	1	--	ut3¹ ese³		5	EU EA WA MN	596
	rs8089^1,2	A,C,F,H	169359651(-)	`GGAACT/GCAGAG`	1	--	ut3¹ ese³		10	MN EU EA WA	1200
	rs6605524^1,2	A,C,F,H	169398045(-)	`GGCCAC/TGTTCC`	1	--	ng3¹		12	EA NA EU WA	1046
	rs6921774^1,2	A,C,F,H	169398004(-)	`GACTTG/CCCTGA`	1	--	ng3¹		12	EA NA EU WA	996
	rs1040^1,2	A,C,F,H	169358272(-)	`GGAACA/GATCCA`	1	--	ut3¹		10	MN NA EU EA WA	992
	rs6940801^1,2	A,C,F,H	169397592(-)	`GTCCCT/CAATAG`	1	--	ng3¹		7	EU EA WA NA	562
	rs3253^1,2	A,C,F,H	169358037(-)	`TGGGAG/ATGACG`	1	--	ut3¹		8	NA MN EU EA WA	730
	rs12435^1,2	A,C,F,H	169359765(-)	`CCTTGT/CGGCTT`	1	--	ut3¹		6	MN EU EA WA	782
	rs9505892^1,2	A,C,F,H	169359036(+)	`CCACAG/ACGGCA`	1	--	ut3¹ ese³		3	EU EA	294
--	rs1132755^1,2	A,C,F	169359354(-)	`TCCCGT/CTAAAT`	1	--	ut3¹		1	MN	184

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HapMap Linkage Disequilibrium images for THBS2 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 188061 disorders: 603932

UniProtKB/Swiss-Prot: TSP2_HUMAN, P35442

Genetic variations in THBS2 may be a cause of susceptibility to lumbar disk herniation

(LDH) [MIM:603932]. LDH is the predominant cause of low-back pain and unilateral leg pain

10/22 Novoseek disease relationships for THBS2 gene (see all 22 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
carcinoma lewis lung	33.85	1	11929817 (1)
collagen fibril	31.07	1	12781637 (1)
tumors	27.34	56	18955754 (6), 10611308 (4), 11929817 (3), 11712798 (3) (see all 17)
carcinoma squamous cell	23.30	6	11929817 (1), 11147670 (1), 14675207 (1), 10611308 (1)
melanoma	22.54	9	12353704 (3), 19082472 (3), 11929817 (1), 9032471 (1) (see all 5)
glioma	21.02	8	10448307 (4), 17919663 (1), 11132930 (1)
metastasis	18.35	14	9888480 (3), 18720079 (2), 12353704 (2), 19082472 (2) (see all 5)
cancer	16.22	3	11147670 (1), 18955754 (1)
breast carcinoma	16.20	4	9012463 (2), 9032471 (1)
malignant glioma	15.20	1	11132930 (1)

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Human Gene Mutation Database: THBS2
Genetic Association Database: THBS2
Human Genome Epidemiology Navigator: THBS2 (10 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/150 PubMed articles for THBS2 gene (see all 150 ):

A functional polymorphism in THBS2 that affects alternative splicing and MMP binding is associated with lumbar-disc herniation. (PubMed id 18455130)^{2, 3, 4} Hirose Y....Ikegawa S. (2008)
Large scale association analysis for identification of genes underlying premature coronary heart disease: cumulative perspective from analysis of 111 candidate genes. (PubMed id 15121769)^{1, 3, 6} McCarthy J.J....Topol E.J. (2004)
Thrombospondin-2 polymorphism is associated with a reduced risk of premature myocardial infarction. (PubMed id 12482844)^{1, 3, 6} Boekholdt S.M....Reitsma P.H. (2002)
Disulfide connectivity of recombinant C-terminal region of human thrombospondin 2. (PubMed id 11590138)^{1, 3, 4} Misenheimer T.M.... Mosher D.F. (2001)
Sequence and characterization of the complete human thrombospondin 2 cDNA: potential regulatory role for the 3' untranslated region. (PubMed id 8406456)^{1, 3, 4} Labell T.L. and Byers P.H. (1993)
Thrombospondin II: partial cDNA sequence, chromosome location, and expression of a second member of the thrombospondin gene family in humans. (PubMed id 1559694)^{3, 4} Labell T.L.... Byers P.H. (1992)
Microvessel density and CpG island methylation of the THBS2 gene in malignant ovarian tumors. (PubMed id 18955754)^{1, 3} Czekierdowski A....Kotarski J. (2008)
Thrombospondin 2 regulates cell proliferation induced by Rac1 redox-dependent signaling. (PubMed id 12861025)^{1, 3} Lopes N....Kovacic H. (2003)
Biophysical characterization of the signature domains of thrombospondin-4 and thrombospondin-2. (PubMed id 16246837)^{1, 3} Misenheimer T.M. and Mosher D.F. (2005)
Loss of heterozygosity on chromosome 6q correlates with decreased thrombospondin-2 expression in human salivary gland carcinomas. (PubMed id 12824879)^{1, 3} Kishi M....Konishi N. (2003)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 7058	HGNC: 11786	AceView: THBS2	Ensembl:ENSG00000186340	euGenes: HUgn7058
ECgene: THBS2	H-InvDB: THBS2

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for THBS2	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for THBS2
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for THBS2:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for THBS2-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for THBS2		Browse antibodies at Sigma-Aldrich
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for THBS2		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

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Antibodies for THBS2

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
THBS2 Gene at Home site.
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THBS2 Gene

protein-coding GIFtS: 66

Aliases &
Descriptions
for THBS2

Summaries
for THBS2

Genomic Location
for THBS2

Proteins
for THBS2

Protein Domains/
Families
for THBS2

Gene Function
for THBS2

Pathways & Interactions
for THBS2

Drugs & Compounds
for THBS2

Transcripts
for THBS2

Expression
for THBS2

Orthologs
for THBS2

Paralogs
for THBS2

SNPs/Variants
for THBS2

Disorders & Mutations
for THBS2

Medical News
for THBS2

Publications
for THBS2

Search for THBS2

Genome Databases showing THBS2

Other Databases showing THBS2

Specialized Databases showing THBS2

Licensable Technologies
for THBS2

Services
for THBS2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

THBS2 Gene

protein-coding GIFtS: 66

Aliases & Descriptionsfor THBS2

Summariesfor THBS2

Genomic Locationfor THBS2

Proteinsfor THBS2

Protein Domains/Familiesfor THBS2

Gene Functionfor THBS2

Pathways & Interactionsfor THBS2

Drugs & Compoundsfor THBS2

Transcriptsfor THBS2

Expression for THBS2

Orthologsfor THBS2

Paralogsfor THBS2

SNPs/Variantsfor THBS2

Disorders & Mutationsfor THBS2

Medical Newsfor THBS2

Publicationsfor THBS2

Search for THBS2

Genome Databases showing THBS2

Other Databases showing THBS2

Specialized Databases showing THBS2

Licensable Technologiesfor THBS2

Servicesfor THBS2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for THBS2

Summaries
for THBS2

Genomic Location
for THBS2

Proteins
for THBS2

Protein Domains/
Families
for THBS2

Gene Function
for THBS2

Pathways & Interactions
for THBS2

Drugs & Compounds
for THBS2

Transcripts
for THBS2

Expression
for THBS2

Orthologs
for THBS2

Paralogs
for THBS2

SNPs/Variants
for THBS2

Disorders & Mutations
for THBS2

Medical News
for THBS2

Publications
for THBS2

Licensable Technologies
for THBS2

Services
for THBS2