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THBS2 Gene

protein-coding   GIFtS: 67
GCID: GC06M169615

Thrombospondin 2

  See THBS2-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Thrombospondin 21 2
TSP22 3
thrombospondin-22

External Ids:    HGNC: 117861   Entrez Gene: 70582   Ensembl: ENSG000001863407   OMIM: 1880615   UniProtKB: P354423   

Export aliases for THBS2 gene to outside databases

Previous GC identifers: GC06U990123 GC06M9S0210 GC06M169433 GC06M167041


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for THBS2 Gene:
The protein encoded by this gene belongs to the thrombospondin family. It is a disulfide-linked homotrimeric
glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. This protein has been shown to function
as a potent inhibitor of tumor growth and angiogenesis. Studies of the mouse counterpart suggest that this
protein may modulate the cell surface properties of mesenchymal cells and be involved in cell adhesion and
migration. (provided by RefSeq, Jul 2008)

GeneCards Summary for THBS2 Gene:
THBS2 (thrombospondin 2) is a protein-coding gene. Diseases associated with THBS2 include lumbar disc herniation, and hydrolethalus syndrome 1. GO annotations related to this gene include heparin binding and calcium ion binding. An important paralog of this gene is THBS1.

UniProtKB/Swiss-Prot: TSP2_HUMAN, P35442
Function: Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Ligand for CD36
mediating antiangiogenic properties

Gene Wiki entry for THBS2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000006.11  NC_018917.2  NT_025741.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the THBS2 gene promoter:
         MyoD   Nkx2-5   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTHBS2 promoter sequence
   Search Chromatin IP Primers for THBS2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat THBS2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q27   Ensembl cytogenetic band:  6q27   HGNC cytogenetic band: 6q27

THBS2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
THBS2 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M169615:  view genomic region     (about GC identifiers)

Start:
169,615,875 bp from pter      End:
169,654,139 bp from pter
Size:
38,265 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: TSP2_HUMAN, P35442 (See protein sequence)
Recommended Name: Thrombospondin-2 precursor  
Size: 1172 amino acids; 129991 Da
Subunit: Homotrimer; disulfide-linked. Interacts (via the TSP type I repeats) with CD36; the interaction conveys
an antiangiogenic effect. Interacts (via the TSP type I repeats) with HRG; the interaction blocks the
antiangiogenic effect of THBS2 with CD36 (By similarity). Can bind to fibrinogen, fibronectin, laminin and type V
collagen
2 PDB 3D structures from and Proteopedia for THBS2:
1YO8 (3D)        2RHP (3D)    
Secondary accessions: A6H8N1 A7E232 Q5RI52

Explore the universe of human proteins at neXtProt for THBS2: NX_P35442

Explore proteomics data for THBS2 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn151, Thr251, Thr252, Ser259, Asn316, Asn330, Asn457, Asn584, Asn710, Asn1069
  • Modification sites at PhosphoSitePlus

  • See THBS2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_003238.2  
    ENSEMBL proteins: 
     ENSP00000355751   ENSP00000398928  
    Reactome Protein details: P35442

    THBS2 Human Recombinant Protein Products:

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    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for THBS2

     
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    antibodies-online proteins for THBS2 

     
    antibodies-online peptides for THBS2

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    antibodies-online antibodies for THBS2 (26 products) 

    THBS2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    R&D Systems ELISAs for THBS2 (Thrombospondin-2)         (see all)
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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for THBS2
    Cloud-Clone Corp. CLIAs for THBS2
    Search eBioscience for ELISAs for THBS2 
    antibodies-online kits for THBS2 (27 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    Selected InterPro protein domains (see all 13):
     IPR000884 Thrombospondin_1_rpt
     IPR001881 EGF-like_Ca-bd_dom
     IPR000742 EG-like_dom
     IPR013320 ConA-like_subgrp
     IPR001791 Laminin_G

    Graphical View of Domain Structure for InterPro Entry P35442

    ProtoNet protein and cluster: P35442

    Selected Blocks protein domains (see all 6):
    IPB000884 Thrombospondin
    IPB001007 von Willebrand factor
    IPB001881 EGF-like calcium-binding
    IPB006210 Type I EGF
    IPB008085 Thrombospondin type 1 repeat signature


    UniProtKB/Swiss-Prot: TSP2_HUMAN, P35442
    Similarity: Belongs to the thrombospondin family
    Similarity: Contains 2 EGF-like domains
    Similarity: Contains 1 laminin G-like domain
    Similarity: Contains 1 TSP C-terminal (TSPC) domain
    Similarity: Contains 3 TSP type-1 domains
    Similarity: Contains 8 TSP type-3 repeats
    Similarity: Contains 1 VWFC domain


    Find genes that share domains with THBS2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TSP2_HUMAN, P35442
    Function: Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Ligand for CD36
    mediating antiangiogenic properties

         Genatlas biochemistry entry for THBS2:
    thrombospondin II,extracellular,glycoprotein expressed in smooth muscle,fibroblast in cell adhesion molecule

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005509calcium ion binding IEA--
    GO:0005515protein binding IPI19818485
    GO:0008201heparin binding IEA--
         
    Find genes that share ontologies with THBS2           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for THBS2:
     Decreased number of cells in m 

         13 MGI mutant phenotypes (inferred from 1 allele(MGI details for Thbs2):
     behavior/neurological  cardiovascular system  cellular  hematopoietic system  homeostasis/metabolism 
     immune system  integument  limbs/digits/tail  mortality/aging  muscle 
     respiratory system  skeleton  tumorigenesis 

    Find genes that share phenotypes with THBS2           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Thbs2tm1Bst for THBS2

       genOway: Develop your customized and physiologically relevant rodent model for THBS2

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat THBS2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate THBS2 (see all 35):
    hsa-miR-582-3p hsa-miR-3938 hsa-miR-30d hsa-miR-9 hsa-miR-124 hsa-miR-30a hsa-miR-506 hsa-miR-181b
    SwitchGear 3'UTR luciferase reporter plasmidTHBS2 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for THBS2
    Predesigned siRNA for gene silencing in human, mouse, rat THBS2

    Gene Editing
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    OriGene clones in human, mouse for THBS2 (see all 6)
    OriGene ORF clones in mouse, rat for THBS2
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    GenScript: all cDNA clones in your preferred vector: THBS2 (NM_003247)
    Sino Biological Human cDNA Clone for THBS2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for THBS2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat THBS2
    Addgene plasmids for THBS2 

    Cell Line
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    ESI BIO PureStem Progenitor for THBS2: 
    PureStem 4D20.8, NCr-fac Progenitor
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for THBS2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular4
    cytosol1
    plasma membrane1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005604basement membrane IEA--
    GO:0031012extracellular matrix ----

    Find genes that share ontologies with THBS2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for THBS2 About   (see all 8)  
    See pathways by source

    SuperPathContained pathways About
    1Focal adhesion
    Focal adhesion0.65
    ECM-receptor interaction0.31
    Focal Adhesion0.65
    2Signaling by FGFR
    Signaling by PDGF0.87
    3Matrix Metalloproteinases
    Inhibition of Matrix Metalloproteinases0.68
    4Signaling by GPCR
    Signal Transduction0.58
    5PI3K-Akt signaling pathway
    PI3K-Akt signaling pathway


    Find genes that share SuperPaths with THBS2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for THBS2
        Notch Signaling Pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for THBS2
        Inhibition of Matrix Metalloproteinases

    1 BioSystems Pathway for THBS2
        Focal Adhesion


    2 Reactome Pathways for THBS2
        O-glycosylation of TSR domain-containing proteins
    Signaling by PDGF


    5 Kegg Pathways  (Kegg details for THBS2):
        Phagosome
    PI3K-Akt signaling pathway
    Focal adhesion
    ECM-receptor interaction
    Malaria

        Pathway & Disease-focused RT2 Profiler PCR Arrays including THBS2: 
              Lung Cancer in human mouse rat
              Fibrosis in human mouse rat
              Extracellular Matrix & Adhesion Molecules in human mouse rat
              Angiogenesis in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for THBS2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for THBS2 (P354421, 3 ENSP000003557514) via UniProtKB, MINT, STRING, and/or I2D (see all 37)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MMP2P082533, ENSP000002190704I2D: score=2 STRING: ENSP00000219070
    THBS3P497463, ENSP000003573624I2D: score=2 STRING: ENSP00000357362
    MMP9P147803, ENSP000003614054I2D: score=3 STRING: ENSP00000361405
    ITGA4ENSP000003802274STRING: ENSP00000380227
    ITGA6ENSP000003868964STRING: ENSP00000386896
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007155cell adhesion IEA--
    GO:0016525negative regulation of angiogenesis IDA--
    GO:0051965positive regulation of synapse assembly IEA--

    Find genes that share ontologies with THBS2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for THBS2 (TSP2)

    Selected Novoseek inferred chemical compound relationships for THBS2 gene (see all 12)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cerivastatin 45.4 1 12605021 (1)
    tgf beta1 40.9 4 15347840 (3), 9016857 (1)
    procollagen 38 1 1426766 (1)
    vegf 32.5 20 16365183 (6), 10448307 (2), 17107379 (2), 10821491 (1) (see all 5)
    acth 17.6 3 10342868 (2), 12358136 (1)
    oligonucleotide 12.7 1 11563036 (1)
    ganciclovir 10.8 1 10950755 (1)
    heparin 9.04 2 8663244 (1), 1459996 (1)
    thymidine 0 3 9016857 (1), 11723011 (1)
    calcium 0 12 16246837 (5), 17620335 (3), 7798222 (1), 18682400 (1)



    Find genes that share compounds with THBS2           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for THBS2 gene: 
    NM_003247.3  

    Unigene Cluster for THBS2:

    Thrombospondin 2
    Hs.371147  [show with all ESTs]
    Unigene Representative Sequence: NM_003247
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000366787(uc003qwt.3) ENST00000488355 ENST00000461848 ENST00000472733
    ENST00000435791
    miRNA
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    Block miRNA regulation of human, mouse, rat THBS2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate THBS2 (see all 35):
    hsa-miR-582-3p hsa-miR-3938 hsa-miR-30d hsa-miR-9 hsa-miR-124 hsa-miR-30a hsa-miR-506 hsa-miR-181b
    SwitchGear 3'UTR luciferase reporter plasmidTHBS2 3' UTR sequence
    Inhib. RNA
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      QuantiFast Probe-based Assays in human, mouse, rat THBS2

    Additional mRNA sequence: 

    AK292429.1 BC127845.1 BC146676.1 BC150175.1 BX641023.1 L12350.1 M81339.1 

    14 DOTS entries:

    DT.318423  DT.86854901  DT.97858822  DT.95261122  DT.100792529  DT.86837324  DT.97858821  DT.100792527 
    DT.100792528  DT.100792531  DT.121351011  DT.40224336  DT.75150060  DT.95149447 

    Selected AceView cDNA sequences (see all 320):

    CN483550 AW581293 AA962069 C00154 CB267812 CA431209 AI750269 AI580302 
    CA449275 BQ940133 BX099356 AA953039 AW068385 CA446830 AI753153 BU736223 
    H88241 BU728348 BX641023 NM_003247 AI130835 AA344029 CA420699 CK000113 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for THBS2 (see all 7)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18 ^
    SP1:                    -     -     -                                               -                             -                 -                           
    SP2:                    -     -     -                                                                                                                           
    SP3:                          -     -                                                                                                                           
    SP4:                                -                                                                                                                           
    SP5:                                                                                                                                                            

    ExUns: 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26
    SP1:                                                
    SP2:                                                
    SP3:                                                
    SP4:                                                
    SP5:                                                


    ECgene alternative splicing isoforms for THBS2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    THBS2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCAGACTCAG
    THBS2 Expression
    About this image


    THBS2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 12) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 6 entries
             Prechondrocytes Stylopod Epiphyseal End
     
     Cartilage (Muscoskeletal System)    fully expand to see all 6 entries
             Prechondrocytes Stylopod Epiphyseal End
     
     Brain (Nervous System)    fully expand to see all 8 entries
             Thalamus
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 4 entries
             Line H9 (Naive)
     
     Limb (Muscoskeletal System)    fully expand to see all 3 entries
             Mesenchymal Condensate Cells Zeugopod
    THBS2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    THBS2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.371147

    UniProtKB/Swiss-Prot: TSP2_HUMAN, P35442
    Tissue specificity: High expression in invertebral disk tissue

        Pathway & Disease-focused RT2 Profiler PCR Arrays including THBS2: 
              Lung Cancer in human mouse rat
              Fibrosis in human mouse rat
              Extracellular Matrix & Adhesion Molecules in human mouse rat
              Angiogenesis in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for THBS2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for THBS2 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Thbs21 , 5 thrombospondin 21, 5 83.92(n)1
    88.64(a)1
      17 (8.95 cM)5
    218261  NM_011581.31  NP_035711.21 
     146655005 
    chicken
    (Gallus gallus)
    Aves THBS21 thrombospondin 2 73.58(n)
    79.59(a)
      414837  NM_001001755.1  NP_001001755.1 
    lizard
    (Anolis carolinensis)
    Reptilia THBS26
    thrombospondin 2
    79(a)
    1 ↔ 1
    1(223967288-224016984)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia thbs21 thrombospondin 2 70.23(n)
    75.96(a)
      100494997  XM_002931513.2  XP_002931559.2 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1005352411 thrombospondin-2-like 69.93(n)
    71.7(a)
      100535241  XM_003199745.2  XP_003199793.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta Tsp3 cell adhesion molecule 45(a)     --


    ENSEMBL Gene Tree for THBS2 (if available)
    TreeFam Gene Tree for THBS2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for THBS2 gene
    THBS12  THBS42  COMP2  THBS32  
    5 SIMAP similar genes for THBS2 using alignment to 2 protein entries:     TSP2_HUMAN (see all proteins):
    DKFZp686G02190    THBS3    COMP    THBS4    THBS1

    Find genes that share paralogs with THBS2           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for THBS2
    PGOHUM00000258302


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for THBS2 (see all 1465)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs732382771,2
    C,F--169615401(+) GCCCGA/GTCGGC 1 -- ds50012Minor allele frequency- G:0.11WA 120
    rs597281971,2
    C--169615416(+) TTTTAG/AGCAGT 1 -- ds50014Minor allele frequency- A:0.09WA NA EA 360
    rs1906896351,2
    C--169615457(+) GGTCCG/TCTACT 1 -- ds50010--------
    rs1410483621,2
    --169615509(+) CAGCTC/TGTATT 1 -- ds50010--------
    rs1468759531,2
    --169615599(+) CCCTCA/GTTTGA 1 -- ds50010--------
    rs1393976201,2
    --169615612(+) ATGAGC/TAGAGG 1 -- ds50010--------
    rs1426925041,2
    C--169615631(+) ATGAAC/TTGCTA 1 -- ds50010--------
    rs725668871,2
    C,F--169615655(+) CACACC/TGTGCT 1 -- ds50011Minor allele frequency- T:0.07EA 120
    rs771500071,2
    C,F--169615656(+) ACACCG/ATGCTG 1 -- ds50011Minor allele frequency- A:0.04NA 120
    rs2004716121,2
    --169615821(+) ACCCC-/TTTCCC 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for THBS2 (169615875 - 169654139 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for THBS2 (see all 18):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2662846CNV Deletion23128226
    esv2733482CNV Deletion23290073
    dgv1174e199CNV Deletion23128226
    esv2733483CNV Deletion23290073
    esv2733477CNV Deletion23290073
    esv2733485CNV Deletion23290073
    esv1974260CNV Deletion18987734
    esv2733480CNV Deletion23290073
    esv2733479CNV Deletion23290073
    esv2743386CNV Deletion23290073

    Human Gene Mutation Database (HGMD): THBS2
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing THBS2
    DNA2.0 Custom Variant and Variant Library Synthesis for THBS2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 188061   
    OMIM disorders: 603932  
    UniProtKB/Swiss-Prot: TSP2_HUMAN, P35442
  • Intervertebral disc disease (IDD) [MIM:603932]: A common musculo-skeletal disorder caused by degeneration
    of intervertebral disks of the lumbar spine. It results in low-back pain and unilateral leg pain. Note=Disease
    susceptibility is associated with variations affecting the gene represented in this entry

  • 4 diseases for THBS2:    
    About MalaCards
    lumbar disc herniation    hydrolethalus syndrome 1    posterior uveal melanoma    hydrolethalus syndrome


    Find genes that share disorders with THBS2           About GenesLikeMe

    Selected Novoseek inferred disease relationships for THBS2 gene (see all 23)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    neovascularization 36.8 1 19578767 (1)
    carcinoma lewis lung 32.3 1 11929817 (1)
    collagen fibril 29.6 1 12781637 (1)
    tumors 29 59 18955754 (6), 10611308 (4), 11929817 (3), 11712798 (3) (see all 20)
    carcinoma squamous cell 21.4 6 11929817 (1), 11147670 (1), 14675207 (1), 10611308 (1)
    melanoma 20.7 9 12353704 (3), 19082472 (3), 11929817 (1), 9032471 (1) (see all 5)
    glioma 18.9 8 10448307 (4), 17919663 (1), 11132930 (1)
    metastasis 18.7 14 9888480 (3), 18720079 (2), 12353704 (2), 19082472 (2) (see all 5)
    cancer 18.6 3 11147670 (1), 18955754 (1)
    breast carcinoma 14.6 4 9012463 (2), 9032471 (1)

    Genetic Association Database (GAD): THBS2
    Human Genome Epidemiology (HuGE) Navigator: THBS2 (17 documents)

    Export disorders for THBS2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for THBS2 gene, integrated from 10 sources (see all 179):
    (articles sorted by number of sources associating them with THBS2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A functional polymorphism in THBS2 that affects alternative splicing and MMP binding is associated with lumbar-disc herniation. (PubMed id 18455130)1, 2, 3, 4 Hirose Y....Ikegawa S. (Am. J. Hum. Genet. 2008)
    2. Polymorphisms in thrombospondin genes and myocardial infarction: a case-control study and a meta-analysis of available evidence. (PubMed id 18178577)1, 4, 9 Koch W....Kastrati A. (Hum. Mol. Genet. 2008)
    3. Large scale association analysis for identification of genes underlying premature coronary heart disease: cumulative perspective from analysis of 111 candidate genes. (PubMed id 15121769)1, 4, 9 McCarthy J.J....Topol E.J. (J. Med. Genet. 2004)
    4. Decreased frequency of the 3'UTR T&gt;G single nucleotide polymorphism of thrombospondin-2 gene in sudden death due to plaque erosion. (PubMed id 19631562)1, 4, 9 Burke A....Fowler D. (Cardiovasc. Pathol. 2010)
    5. Assessment of genetic risk factors for thoracic aortic aneurysm in hypertensive patients. (PubMed id 18600213)1, 4, 9 Kato K....Yamada Y. (Am. J. Hypertens. 2008)
    6. Structure of the calcium-rich signature domain of human thrombospondin-2. (PubMed id 16186819)1, 2, 9 Carlson C.B.... Keck J.L. (Nat. Struct. Mol. Biol. 2005)
    7. Thrombospondin-2 polymorphism is associated with a reduced risk of premature myocardial infarction. (PubMed id 12482844)1, 4, 9 Boekholdt S.M....Reitsma P.H. (Arterioscler. Thromb. Vasc. Biol. 2002)
    8. Disulfide connectivity of recombinant C-terminal region of human thrombospondin 2. (PubMed id 11590138)1, 2, 9 Misenheimer T.M.... Mosher D.F. (J. Biol. Chem. 2001)
    9. Sequence and characterization of the complete human thrombospondin 2 cDNA: potential regulatory role for the 3' untranslated region. (PubMed id 8406456)1, 2, 9 Labell T.L. and Byers P.H. (Genomics 1993)
    10. Association of common promoter polymorphisms of MCP1 with hepatitis B virus clearance. (PubMed id 17202846)1, 4, 9 Park B.L....Shin H.D. (amp 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 7058 HGNC: 11786 AceView: THBS2 Ensembl:ENSG00000186340 euGenes: HUgn7058
    ECgene: THBS2 Kegg: 7058 H-InvDB: THBS2

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for THBS2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for THBS2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for THBS2 gene:
    Search GeneIP for patents involving THBS2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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