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Aliases for THBS2 Gene

Aliases for THBS2 Gene

  • Thrombospondin 2 2 3 5
  • TSP2 3 4

External Ids for THBS2 Gene

Previous GeneCards Identifiers for THBS2 Gene

  • GC06U990123
  • GC06M9S0210
  • GC06M169433
  • GC06M169615
  • GC06M167041

Summaries for THBS2 Gene

Entrez Gene Summary for THBS2 Gene

  • The protein encoded by this gene belongs to the thrombospondin family. It is a disulfide-linked homotrimeric glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. This protein has been shown to function as a potent inhibitor of tumor growth and angiogenesis. Studies of the mouse counterpart suggest that this protein may modulate the cell surface properties of mesenchymal cells and be involved in cell adhesion and migration. [provided by RefSeq, Jul 2008]

GeneCards Summary for THBS2 Gene

THBS2 (Thrombospondin 2) is a Protein Coding gene. Diseases associated with THBS2 include Intervertebral Disc Disease and Posterior Uveal Melanoma. Among its related pathways are Malaria and PI3K-Akt signaling pathway. GO annotations related to this gene include calcium ion binding and heparin binding. An important paralog of this gene is THBS4.

UniProtKB/Swiss-Prot for THBS2 Gene

  • Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Ligand for CD36 mediating antiangiogenic properties.

Gene Wiki entry for THBS2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for THBS2 Gene

Genomics for THBS2 Gene

Regulatory Elements for THBS2 Gene

Enhancers for THBS2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around THBS2 on UCSC Golden Path with GeneCards custom track

Promoters for THBS2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around THBS2 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the THBS2 gene promoter:

Genomic Location for THBS2 Gene

169,215,780 bp from pter
169,254,114 bp from pter
38,335 bases
Minus strand

Genomic View for THBS2 Gene

Genes around THBS2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
THBS2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for THBS2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for THBS2 Gene

Proteins for THBS2 Gene

  • Protein details for THBS2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • A6H8N1
    • A7E232
    • Q5RI52

    Protein attributes for THBS2 Gene

    1172 amino acids
    Molecular mass:
    129991 Da
    Quaternary structure:
    • Homotrimer; disulfide-linked. Interacts (via the TSP type I repeats) with CD36; the interaction conveys an antiangiogenic effect. Interacts (via the TSP type I repeats) with HRG; the interaction blocks the antiangiogenic effect of THBS2 with CD36 (By similarity). Can bind to fibrinogen, fibronectin, laminin and type V collagen.

    Three dimensional structures from OCA and Proteopedia for THBS2 Gene

neXtProt entry for THBS2 Gene

Proteomics data for THBS2 Gene at MOPED

Post-translational modifications for THBS2 Gene

  • Glycosylation at Asn 151, Thr 252, Asn 316, Asn 330, Asn 457, Asn 584, Asn 710, and Asn 1069
  • Modification sites at PhosphoSitePlus

Other Protein References for THBS2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for THBS2 (Thrombospondin-2)

No data available for DME Specific Peptides for THBS2 Gene

Domains & Families for THBS2 Gene

Suggested Antigen Peptide Sequences for THBS2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 2 EGF-like domains.
  • Belongs to the thrombospondin family.
  • Contains 8 TSP type-3 repeats.
  • Contains 2 EGF-like domains.
  • Contains 1 laminin G-like domain.
  • Contains 1 TSP C-terminal (TSPC) domain.
  • Contains 3 TSP type-1 domains.
  • Contains 1 VWFC domain.
  • Belongs to the thrombospondin family.
  • Contains 8 TSP type-3 repeats.
genes like me logo Genes that share domains with THBS2: view

No data available for Gene Families for THBS2 Gene

Function for THBS2 Gene

Molecular function for THBS2 Gene

GENATLAS Biochemistry:
thrombospondin II,extracellular,glycoprotein expressed in smooth muscle,fibroblast in cell adhesion molecule
UniProtKB/Swiss-Prot Function:
Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Ligand for CD36 mediating antiangiogenic properties.
genes like me logo Genes that share phenotypes with THBS2: view

Animal Models for THBS2 Gene

MGI Knock Outs for THBS2:

Animal Model Products

miRNA for THBS2 Gene

miRTarBase miRNAs that target THBS2

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for THBS2 Gene

Localization for THBS2 Gene

Subcellular locations from

Jensen Localization Image for THBS2 Gene COMPARTMENTS Subcellular localization image for THBS2 gene
Compartment Confidence
extracellular 5
plasma membrane 3
cytosol 2
nucleus 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for THBS2 Gene

Pathways & Interactions for THBS2 Gene

genes like me logo Genes that share pathways with THBS2: view

Pathways by source for THBS2 Gene

SIGNOR curated interactions for THBS2 Gene


Gene Ontology (GO) - Biological Process for THBS2 Gene


Drugs & Compounds for THBS2 Gene

(8) Drugs for THBS2 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(4) Additional Compounds for THBS2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with THBS2: view

Transcripts for THBS2 Gene

Unigene Clusters for THBS2 Gene

Thrombospondin 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for THBS2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18 ^
SP1: - - - - - -
SP2: - - -
SP3: - -
SP4: -

ExUns: 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26

Relevant External Links for THBS2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for THBS2 Gene

mRNA expression in normal human tissues for THBS2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for THBS2 Gene

This gene is overexpressed in Artery - Aorta (x9.9) and Artery - Coronary (x7.9).

Protein differential expression in normal tissues from HIPED for THBS2 Gene

This gene is overexpressed in Amniocyte (22.7), Breast (17.5), Pancreas (9.1), Cerebrospinal fluid (6.9), and Bone marrow mesenchymal stem cell (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for THBS2 Gene

SOURCE GeneReport for Unigene cluster for THBS2 Gene Hs.371147

mRNA Expression by UniProt/SwissProt for THBS2 Gene

Tissue specificity: High expression in invertebral disk tissue.
genes like me logo Genes that share expression patterns with THBS2: view

Primer Products

No data available for Protein tissue co-expression partners for THBS2 Gene

Orthologs for THBS2 Gene

This gene was present in the common ancestor of animals.

Orthologs for THBS2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia THBS2 35
  • 85.64 (n)
  • 90.48 (a)
THBS2 36
  • 91 (a)
(Canis familiaris)
Mammalia THBS2 35
  • 86.91 (n)
  • 91.46 (a)
THBS2 36
  • 89 (a)
(Mus musculus)
Mammalia Thbs2 35
  • 83.92 (n)
  • 88.64 (a)
Thbs2 16
Thbs2 36
  • 89 (a)
(Pan troglodytes)
Mammalia THBS2 35
  • 94.37 (n)
  • 93.17 (a)
(Rattus norvegicus)
Mammalia Thbs2 35
  • 83.4 (n)
  • 88.47 (a)
(Monodelphis domestica)
Mammalia THBS2 36
  • 85 (a)
(Ornithorhynchus anatinus)
Mammalia THBS2 36
  • 84 (a)
(Gallus gallus)
Aves THBS2 35
  • 73.58 (n)
  • 79.59 (a)
THBS2 36
  • 77 (a)
(Anolis carolinensis)
Reptilia THBS2 36
  • 79 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia thbs2 35
  • 70.23 (n)
  • 75.96 (a)
(Danio rerio)
Actinopterygii LOC100535241 35
  • 69.93 (n)
  • 71.7 (a)
thbs2a 36
  • 71 (a)
thbs2a 36
  • 71 (a)
thbs2b 36
  • 69 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6394 35
fruit fly
(Drosophila melanogaster)
Insecta Tsp 37
  • 45 (a)
Tsp 36
  • 37 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 50 (a)
Species with no ortholog for THBS2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for THBS2 Gene

Gene Tree for THBS2 (if available)
Gene Tree for THBS2 (if available)

Paralogs for THBS2 Gene

(5) SIMAP similar genes for THBS2 Gene using alignment to 2 proteins: Pseudogenes for THBS2 Gene

genes like me logo Genes that share paralogs with THBS2: view

Variants for THBS2 Gene

Sequence variations from dbSNP and Humsavar for THBS2 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs36088849 - 169,248,628(-) CGGCA(C/G)CCGGC reference, missense
VAR_045843 -
rs6422749 -- 169,256,049(-) TCAAC(C/T)GGGGA upstream-variant-2KB
rs6605524 -- 169,256,025(-) GGCCA(C/T)GTTCC upstream-variant-2KB
rs6906765 -- 169,240,434(-) AACAC(A/G)GCTCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for THBS2 Gene

Variant ID Type Subtype PubMed ID
dgv7047n71 CNV Gain 21882294
dgv7048n71 CNV Loss 21882294
esv2733477 CNV Deletion 23290073
esv2733479 CNV Deletion 23290073
esv2662846 CNV Deletion 23128226
esv2733480 CNV Deletion 23290073
esv1974260 CNV Deletion 18987734
nsv887008 CNV Loss 21882294
nsv5597 CNV Loss 18451855
esv28652 CNV Loss 19812545
nsv820425 CNV Duplication 20802225
dgv1174e199 CNV Deletion 23128226
esv2733481 CNV Deletion 23290073
esv6700 CNV Loss 19470904
esv2733482 CNV Deletion 23290073
esv2743386 CNV Deletion 23290073
esv2733483 CNV Deletion 23290073
esv2733485 CNV Deletion 23290073

Variation tolerance for THBS2 Gene

Residual Variation Intolerance Score: 46.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.10; 61.09% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for THBS2 Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for THBS2 Gene

Disorders for THBS2 Gene

MalaCards: The human disease database

(6) MalaCards diseases for THBS2 Gene - From: OMIM, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
intervertebral disc disease
  • lumbar disc herniation
posterior uveal melanoma
  • medium/large size posterior uveal melanoma
spinal stenosis
  • cervical spinal stenosis
intestinal schistosomiasis
  • katayama fever
back pain
- elite association - COSMIC cancer census association via MalaCards
Search THBS2 in MalaCards View complete list of genes associated with diseases


  • Intervertebral disc disease (IDD) [MIM:603932]: A common musculo-skeletal disorder caused by degeneration of intervertebral disks of the lumbar spine. It results in low-back pain and unilateral leg pain. {ECO:0000269 PubMed:18455130}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

Relevant External Links for THBS2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with THBS2: view

No data available for Genatlas for THBS2 Gene

Publications for THBS2 Gene

  1. A functional polymorphism in THBS2 that affects alternative splicing and MMP binding is associated with lumbar-disc herniation. (PMID: 18455130) Hirose Y. … Ikegawa S. (Am. J. Hum. Genet. 2008) 2 3 4 48 67
  2. Decreased frequency of the 3'UTR T>G single nucleotide polymorphism of thrombospondin-2 gene in sudden death due to plaque erosion. (PMID: 19631562) Burke A. … Fowler D. (Cardiovasc. Pathol. 2010) 3 23
  3. Expression profiling of supraglottic carcinoma: PTEN and thrombospondin 2 are associated with inhibition of lymphatic metastasis. (PMID: 18720079) Bai W. … Gao H. (Acta Otolaryngol. 2009) 3 23
  4. Tumor-derived pancreatic stellate cells promote pancreatic cancer cell invasion through release of thrombospondin-2. (PMID: 19592030) Farrow B. … Rowley D. (J. Surg. Res. 2009) 3 23
  5. Polymorphisms in thrombospondin genes and myocardial infarction: a case-control study and a meta-analysis of available evidence. (PMID: 18178577) Koch W. … Kastrati A. (Hum. Mol. Genet. 2008) 3 23

Products for THBS2 Gene

Sources for THBS2 Gene