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Aliases for THBS2 Gene

Aliases for THBS2 Gene

  • Thrombospondin 2 2 3 5
  • TSP2 3 4
  • Thrombospondin-2 3

External Ids for THBS2 Gene

Previous GeneCards Identifiers for THBS2 Gene

  • GC06U990123
  • GC06M9S0210
  • GC06M169433
  • GC06M169615
  • GC06M167041

Summaries for THBS2 Gene

Entrez Gene Summary for THBS2 Gene

  • The protein encoded by this gene belongs to the thrombospondin family. It is a disulfide-linked homotrimeric glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. This protein has been shown to function as a potent inhibitor of tumor growth and angiogenesis. Studies of the mouse counterpart suggest that this protein may modulate the cell surface properties of mesenchymal cells and be involved in cell adhesion and migration. [provided by RefSeq, Jul 2008]

GeneCards Summary for THBS2 Gene

THBS2 (Thrombospondin 2) is a Protein Coding gene. Diseases associated with THBS2 include Intervertebral Disc Disease and Back Pain. Among its related pathways are RET signaling and O-glycosylation of TSR domain-containing proteins. GO annotations related to this gene include calcium ion binding and heparin binding. An important paralog of this gene is THBS1.

UniProtKB/Swiss-Prot for THBS2 Gene

  • Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Ligand for CD36 mediating antiangiogenic properties.

Gene Wiki entry for THBS2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for THBS2 Gene

Genomics for THBS2 Gene

Regulatory Elements for THBS2 Gene

Enhancers for THBS2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06F169069 1.5 FANTOM5 Ensembl ENCODE 12 +181.2 181168 7.8 CTCF MAX SIN3A ZBTB40 RAD21 YY1 HIC1 GATA3 CBX5 HNF4G THBS2 LOC102724357 GC06P169164 PIR53465
GH06F169095 1.7 FANTOM5 Ensembl ENCODE 6.6 +154.8 154791 6.7 CTCF ZBTB11 BHLHE40 RAD21 ZNF316 JUND ZNF157 SMC3 ZBTB33 FOS THBS2 LOC102724357 PIR53465 GC06P169164
GH06F169216 0.6 ENCODE 5.3 +37.1 37065 0.4 RING1 RNF2 LINC01615 THBS2 LOC101929523
GH06F169223 0.9 ENCODE 5.1 +29.0 29025 2.4 PKNOX1 ESRRA JUN RAD21 ZIC2 ZEB1 POLR2A SCRT2 SMC3 TRIM24 LOC101929523 THBS2 LINC01615
GH06F169212 0.2 ENCODE 4.9 +39.8 39778 3.8 ELF3 CBX3 PKNOX1 RAD21 YY1 CBX5 FOS CREM HCFC1 ZBTB11 LOC101929523 LINC01615 THBS2
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around THBS2 on UCSC Golden Path with GeneCards custom track

Promoters for THBS2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001233910 1414 3001 PKNOX1 BHLHE40 MAX SIN3A ATF2 JUND POLR2A POU5F1 SMC3 KDM1A

Genomic Location for THBS2 Gene

Chromosome:
6
Start:
169,215,780 bp from pter
End:
169,254,114 bp from pter
Size:
38,335 bases
Orientation:
Minus strand

Genomic View for THBS2 Gene

Genes around THBS2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
THBS2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for THBS2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for THBS2 Gene

Proteins for THBS2 Gene

  • Protein details for THBS2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P35442-TSP2_HUMAN
    Recommended name:
    Thrombospondin-2
    Protein Accession:
    P35442
    Secondary Accessions:
    • A6H8N1
    • A7E232
    • Q5RI52

    Protein attributes for THBS2 Gene

    Size:
    1172 amino acids
    Molecular mass:
    129991 Da
    Quaternary structure:
    • Homotrimer; disulfide-linked. Interacts (via the TSP type I repeats) with CD36; the interaction conveys an antiangiogenic effect. Interacts (via the TSP type I repeats) with HRG; the interaction blocks the antiangiogenic effect of THBS2 with CD36 (By similarity). Can bind to fibrinogen, fibronectin, laminin and type V collagen.

    Three dimensional structures from OCA and Proteopedia for THBS2 Gene

neXtProt entry for THBS2 Gene

Post-translational modifications for THBS2 Gene

  • Glycosylation at Asn 151, Thr 252, Asn 316, Asn 330, Asn 457, Asn 584, Asn 710, and Asn 1069
  • Modification sites at PhosphoSitePlus

Other Protein References for THBS2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for THBS2 (Thrombospondin-2)
  • Cloud-Clone Corp. Antibodies for THBS2

No data available for DME Specific Peptides for THBS2 Gene

Domains & Families for THBS2 Gene

Suggested Antigen Peptide Sequences for THBS2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P35442

UniProtKB/Swiss-Prot:

TSP2_HUMAN :
  • Contains 2 EGF-like domains.
  • Belongs to the thrombospondin family.
  • Contains 8 TSP type-3 repeats.
Domain:
  • Contains 2 EGF-like domains.
  • Contains 1 laminin G-like domain.
  • Contains 1 TSP C-terminal (TSPC) domain.
  • Contains 3 TSP type-1 domains.
  • Contains 1 VWFC domain.
Family:
  • Belongs to the thrombospondin family.
Similarity:
  • Contains 8 TSP type-3 repeats.
genes like me logo Genes that share domains with THBS2: view

No data available for Gene Families for THBS2 Gene

Function for THBS2 Gene

Molecular function for THBS2 Gene

GENATLAS Biochemistry:
thrombospondin II,extracellular,glycoprotein expressed in smooth muscle,fibroblast in cell adhesion molecule
UniProtKB/Swiss-Prot Function:
Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Ligand for CD36 mediating antiangiogenic properties.

Gene Ontology (GO) - Molecular Function for THBS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IEA --
GO:0005515 protein binding IPI 19818485
GO:0008201 heparin binding IEA,TAS --
genes like me logo Genes that share ontologies with THBS2: view
genes like me logo Genes that share phenotypes with THBS2: view

Animal Models for THBS2 Gene

MGI Knock Outs for THBS2:

Animal Model Products

miRNA for THBS2 Gene

miRTarBase miRNAs that target THBS2

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for THBS2

Cell Line Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for THBS2 Gene

Localization for THBS2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for THBS2 Gene COMPARTMENTS Subcellular localization image for THBS2 gene
Compartment Confidence
extracellular 5
plasma membrane 3
cytosol 2
nucleus 2

Gene Ontology (GO) - Cellular Components for THBS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005578 proteinaceous extracellular matrix IEA --
GO:0005604 basement membrane IEA --
GO:0005615 extracellular space IEA --
GO:0031012 extracellular matrix IEA --
genes like me logo Genes that share ontologies with THBS2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for THBS2 Gene

Pathways & Interactions for THBS2 Gene

genes like me logo Genes that share pathways with THBS2: view

Pathways by source for THBS2 Gene

SIGNOR curated interactions for THBS2 Gene

Activates:

Gene Ontology (GO) - Biological Process for THBS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion IEA --
GO:0016525 negative regulation of angiogenesis IDA 20714802
GO:0051965 positive regulation of synapse assembly IEA --
genes like me logo Genes that share ontologies with THBS2: view

Drugs & Compounds for THBS2 Gene

(8) Drugs for THBS2 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(4) Additional Compounds for THBS2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with THBS2: view

Transcripts for THBS2 Gene

Unigene Clusters for THBS2 Gene

Thrombospondin 2:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for THBS2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for THBS2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18 ^
SP1: - - - - - -
SP2: - - -
SP3: - -
SP4: -
SP5:
SP6:
SP7:

ExUns: 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:

Relevant External Links for THBS2 Gene

GeneLoc Exon Structure for
THBS2
ECgene alternative splicing isoforms for
THBS2

Expression for THBS2 Gene

mRNA expression in normal human tissues for THBS2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for THBS2 Gene

This gene is overexpressed in Artery - Aorta (x9.9) and Artery - Coronary (x7.9).

Protein differential expression in normal tissues from HIPED for THBS2 Gene

This gene is overexpressed in Amniocyte (22.7), Breast (17.5), Pancreas (9.1), Cerebrospinal fluid (6.9), and Bone marrow mesenchymal stem cell (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for THBS2 Gene



NURSA nuclear receptor signaling pathways regulating expression of THBS2 Gene:

THBS2

SOURCE GeneReport for Unigene cluster for THBS2 Gene:

Hs.371147

mRNA Expression by UniProt/SwissProt for THBS2 Gene:

P35442-TSP2_HUMAN
Tissue specificity: High expression in invertebral disk tissue.
genes like me logo Genes that share expression patterns with THBS2: view

Primer Products

No data available for Protein tissue co-expression partners for THBS2 Gene

Orthologs for THBS2 Gene

This gene was present in the common ancestor of animals.

Orthologs for THBS2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia THBS2 34
  • 94.37 (n)
dog
(Canis familiaris)
Mammalia THBS2 34 35
  • 86.91 (n)
cow
(Bos Taurus)
Mammalia THBS2 34 35
  • 85.64 (n)
oppossum
(Monodelphis domestica)
Mammalia THBS2 35
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia THBS2 35
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Thbs2 34 16 35
  • 83.92 (n)
rat
(Rattus norvegicus)
Mammalia Thbs2 34
  • 83.4 (n)
chicken
(Gallus gallus)
Aves THBS2 34 35
  • 73.58 (n)
lizard
(Anolis carolinensis)
Reptilia THBS2 35
  • 79 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia thbs2 34
  • 70.23 (n)
zebrafish
(Danio rerio)
Actinopterygii thbs2a 35 35
  • 71 (a)
OneToMany
LOC100535241 34
  • 69.93 (n)
thbs2b 35
  • 69 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6394 34
fruit fly
(Drosophila melanogaster)
Insecta Tsp 36 35
  • 45 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 50 (a)
OneToMany
Species where no ortholog for THBS2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for THBS2 Gene

ENSEMBL:
Gene Tree for THBS2 (if available)
TreeFam:
Gene Tree for THBS2 (if available)

Paralogs for THBS2 Gene

Paralogs for THBS2 Gene

(5) SIMAP similar genes for THBS2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with THBS2: view

Variants for THBS2 Gene

Sequence variations from dbSNP and Humsavar for THBS2 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1003 -- 169,216,342(-) TAGTA(A/G)GAGAA intron-variant, utr-variant-3-prime
rs10280 -- 169,217,335(+) TTTAA(C/T)GGGAT intron-variant, utr-variant-3-prime
rs1040 -- 169,216,252(-) GGAAC(A/G)ATCCA intron-variant, utr-variant-3-prime
rs1041 -- 169,216,332(-) AGTCT(A/G)TCTGT intron-variant, utr-variant-3-prime
rs1042 -- 169,216,236(-) TTAGT(C/T)TTAAT intron-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for THBS2 Gene

Variant ID Type Subtype PubMed ID
dgv1174e199 CNV deletion 23128226
dgv1856e212 CNV loss 25503493
dgv3719e59 CNV duplication 20981092
dgv6203n100 CNV gain 25217958
esv1974260 CNV deletion 18987734
esv2662846 CNV deletion 23128226
esv2733477 CNV deletion 23290073
esv2733479 CNV deletion 23290073
esv2733480 CNV deletion 23290073
esv2733481 CNV deletion 23290073
esv2733482 CNV deletion 23290073
esv2733483 CNV deletion 23290073
esv2733485 CNV deletion 23290073
esv2743386 CNV deletion 23290073
esv28652 CNV loss 19812545
esv3331909 CNV duplication 20981092
esv3386316 CNV duplication 20981092
esv3540936 CNV deletion 23714750
esv3540937 CNV deletion 23714750
esv3571545 CNV loss 25503493
esv6700 CNV loss 19470904
nsv1024782 CNV gain 25217958
nsv1032232 CNV loss 25217958
nsv1128293 CNV deletion 24896259
nsv1150260 CNV deletion 26484159
nsv5597 CNV deletion 18451855
nsv605497 CNV gain 21841781
nsv605499 CNV gain 21841781
nsv605505 CNV gain 21841781
nsv605506 CNV loss 21841781
nsv820425 CNV duplication 20802225
nsv949901 CNV deletion 24416366

Variation tolerance for THBS2 Gene

Residual Variation Intolerance Score: 46.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.10; 61.09% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for THBS2 Gene

Human Gene Mutation Database (HGMD)
THBS2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
THBS2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for THBS2 Gene

Disorders for THBS2 Gene

MalaCards: The human disease database

(5) MalaCards diseases for THBS2 Gene - From: OMIM, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
intervertebral disc disease
  • lumbar disc herniation
back pain
posterior uveal melanoma
  • medium/large size posterior uveal melanoma
spinal stenosis
  • cervical spinal stenosis
intestinal schistosomiasis
  • katayama fever
- elite association - COSMIC cancer census association via MalaCards
Search THBS2 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

TSP2_HUMAN
  • Intervertebral disc disease (IDD) [MIM:603932]: A common musculo-skeletal disorder caused by degeneration of intervertebral disks of the lumbar spine. It results in low-back pain and unilateral leg pain. {ECO:0000269 PubMed:18455130}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

Relevant External Links for THBS2

Genetic Association Database (GAD)
THBS2
Human Genome Epidemiology (HuGE) Navigator
THBS2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
THBS2
genes like me logo Genes that share disorders with THBS2: view

No data available for Genatlas for THBS2 Gene

Publications for THBS2 Gene

  1. A functional polymorphism in THBS2 that affects alternative splicing and MMP binding is associated with lumbar-disc herniation. (PMID: 18455130) Hirose Y. … Ikegawa S. (Am. J. Hum. Genet. 2008) 2 3 4 46 64
  2. Decreased frequency of the 3'UTR T>G single nucleotide polymorphism of thrombospondin-2 gene in sudden death due to plaque erosion. (PMID: 19631562) Burke A. … Fowler D. (Cardiovasc. Pathol. 2010) 3 22 46 64
  3. Polymorphisms in thrombospondin genes and myocardial infarction: a case-control study and a meta-analysis of available evidence. (PMID: 18178577) Koch W. … Kastrati A. (Hum. Mol. Genet. 2008) 3 22 46 64
  4. Assessment of genetic risk factors for thoracic aortic aneurysm in hypertensive patients. (PMID: 18600213) Kato K. … Yamada Y. (Am. J. Hypertens. 2008) 3 22 46 64
  5. Association of common promoter polymorphisms of MCP1 with hepatitis B virus clearance. (PMID: 17202846) Park B.L. … Shin H.D. (Exp. Mol. Med. 2006) 3 22 46 64

Products for THBS2 Gene

Sources for THBS2 Gene

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