External Ids for THBS2 Gene
Previous GeneCards Identifiers for THBS2 Gene
The protein encoded by this gene belongs to the thrombospondin family. It is a disulfide-linked homotrimeric glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. This protein has been shown to function as a potent inhibitor of tumor growth and angiogenesis. Studies of the mouse counterpart suggest that this protein may modulate the cell surface properties of mesenchymal cells and be involved in cell adhesion and migration. [provided by RefSeq, Jul 2008]
GeneCards Summary for THBS2 Gene
THBS2 (Thrombospondin 2) is a Protein Coding gene. Diseases associated with THBS2 include Intervertebral Disc Disease and Posterior Uveal Melanoma. Among its related pathways are Notch signaling pathway (KEGG) and O-glycosylation of TSR domain-containing proteins. GO annotations related to this gene include calcium ion binding and heparin binding. An important paralog of this gene is THBS1.
UniProtKB/Swiss-Prot for THBS2 Gene
Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Ligand for CD36 mediating antiangiogenic properties.