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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

THBS2 Gene

protein-coding   GIFtS: 67
GCID: GC06M169615

Thrombospondin 2

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Thrombospondin 21 2
TSP22 3
thrombospondin-22

External Ids:    HGNC: 117861   Entrez Gene: 70582   Ensembl: ENSG000001863407   OMIM: 1880615   UniProtKB: P354423   

Export aliases for THBS2 gene to outside databases

Previous GC identifers: GC06U990123 GC06M9S0210 GC06M169433 GC06M167041


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for THBS2 Gene:
The protein encoded by this gene belongs to the thrombospondin family. It is a disulfide-linked homotrimeric
glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. This protein has been shown to function
as a potent inhibitor of tumor growth and angiogenesis. Studies of the mouse counterpart suggest that this
protein may modulate the cell surface properties of mesenchymal cells and be involved in cell adhesion and
migration. (provided by RefSeq, Jul 2008)

GeneCards Summary for THBS2 Gene: 
THBS2 (thrombospondin 2) is a protein-coding gene. Diseases associated with THBS2 include lumbar disc herniation, and posterior uveal melanoma, and among its related super-pathways are Focal Adhesion and Downstream signal transduction. GO annotations related to this gene include heparin binding and calcium ion binding. An important paralog of this gene is THBS1.

UniProtKB/Swiss-Prot: TSP2_HUMAN, P35442
Function: Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Ligand for CD36
mediating antiangiogenic properties

Gene Wiki entry for THBS2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NC_018917.2  NT_025741.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the THBS2 gene promoter:
         MyoD   Nkx2-5   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTHBS2 promoter sequence
   Search SABiosciences Chromatin IP Primers for THBS2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat THBS2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q27   Ensembl cytogenetic band:  6q27   HGNC cytogenetic band: 6q27

THBS2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
THBS2 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M169615:  view genomic region     (about GC identifiers)

Start:
169,615,875 bp from pter      End:
169,654,139 bp from pter
Size:
38,265 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TSP2_HUMAN, P35442 (See protein sequence)
Recommended Name: Thrombospondin-2 precursor  
Size: 1172 amino acids; 129991 Da
Subunit: Homotrimer; disulfide-linked. Interacts (via the TSP type I repeats) with CD36; the interaction conveys
an antiangiogenic effect. Interacts (via the TSP type I repeats) with HRG; the interaction blocks the
antiangiogenic effect of THBS2 with CD36 (By similarity). Can bind to fibrinogen, fibronectin, laminin and type V
collagen
2 PDB 3D structures from and Proteopedia for THBS2:
1YO8 (3D)        2RHP (3D)    
Secondary accessions: A6H8N1 A7E232 Q5RI52

Explore the universe of human proteins at neXtProt for THBS2: NX_P35442

Explore proteomics data for THBS2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P35442

  • THBS2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    THBS2 Protein Expression
    REFSEQ proteins: NP_003238.2  
    ENSEMBL proteins: 
     ENSP00000355751   ENSP00000398928  
    Reactome Protein details: P35442
    Human Recombinant Protein Products for THBS2: 
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    Novus Biologicals THBS2 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for THBS2 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005604basement membrane IEA--
    GO:0031012extracellular matrix ----

    THBS2 for ontologies           About GeneDecksing



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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for THBS2 
    Cloud-Clone Corp. CLIAs for THBS2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5/13 InterPro protein domains (see all 13):
     IPR000884 Thrombospondin_1_rpt
     IPR001881 EGF-like_Ca-bd
     IPR000742 EG-like_dom
     IPR013320 ConA-like_subgrp
     IPR001791 Laminin_G

    Graphical View of Domain Structure for InterPro Entry P35442

    ProtoNet protein and cluster: P35442

    5/6 Blocks protein domains (see all 6):
    IPB000884 Thrombospondin
    IPB001007 von Willebrand factor
    IPB001881 EGF-like calcium-binding
    IPB006210 Type I EGF
    IPB008085 Thrombospondin type 1 repeat signature


    UniProtKB/Swiss-Prot: TSP2_HUMAN, P35442
    Similarity: Belongs to the thrombospondin family
    Similarity: Contains 2 EGF-like domains
    Similarity: Contains 1 laminin G-like domain
    Similarity: Contains 1 TSP C-terminal (TSPC) domain
    Similarity: Contains 3 TSP type-1 domains
    Similarity: Contains 8 TSP type-3 repeats
    Similarity: Contains 1 VWFC domain


    THBS2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TSP2_HUMAN, P35442
    Function: Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Ligand for CD36
    mediating antiangiogenic properties

         Genatlas biochemistry entry for THBS2:
    thrombospondin II,extracellular,glycoprotein expressed in smooth muscle,fibroblast in cell adhesion molecule

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005509calcium ion binding IEA--
    GO:0005515protein binding IPI19818485
    GO:0008201heparin binding IEA--
         
    THBS2 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for THBS2:
     Decreased number of cells in m 

         13 MGI mutant phenotypes (inferred from 1 allele(MGI details for Thbs2):
     behavior/neurological  cardiovascular system  cellular  hematopoietic system  homeostasis/metabolism 
     immune system  integument  limbs/digits/tail  mortality/aging  muscle 
     respiratory system  skeleton  tumorigenesis 

    THBS2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Thbs2tm1Bst for THBS2

       inGenious Targeting Laboratory - Custom generated mouse model solutions for THBS2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for THBS2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for THBS2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for THBS2 

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    SwitchGear 3'UTR luciferase reporter plasmidTHBS2 3' UTR sequence
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for THBS2 About   (see all 9)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Focal Adhesion
    Focal Adhesion0.64
    Focal adhesion0.64
    2Signaling by FGFR
    Signaling by PDGF0.85
    3Matrix Metalloproteinases
    Inhibition of Matrix Metalloproteinases0.68
    4Signaling by GPCR
    Signal Transduction0.55
    5Non-integrin membrane-ECM interactions
    ECM-receptor interaction0.42

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for THBS2
        Notch Signaling Pathways

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for THBS2
        Inhibition of Matrix Metalloproteinases

    1 BioSystems Pathway for THBS2
        Focal Adhesion


    2        Reactome Pathways for THBS2
        Signal Transduction
    Signaling by PDGF


    5         Kegg Pathways  (Kegg details for THBS2):
        Phagosome
    PI3K-Akt signaling pathway
    Focal adhesion
    ECM-receptor interaction
    Malaria


    THBS2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for THBS2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/37 Interacting proteins for THBS2 (P354421, 3 ENSP000003557514) via UniProtKB, MINT, STRING, and/or I2D (see all 37)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MMP2P082533, ENSP000002190704I2D: score=2 STRING: ENSP00000219070
    THBS3P497463, ENSP000003573624I2D: score=2 STRING: ENSP00000357362
    MMP9P147803, ENSP000003614054I2D: score=3 STRING: ENSP00000361405
    ITGA4ENSP000003802274STRING: ENSP00000380227
    ITGA6ENSP000003868964STRING: ENSP00000386896
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007155cell adhesion IEA--
    GO:0016525negative regulation of angiogenesis IDA--

    THBS2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    THBS2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for THBS2 (TSP2)

    10/12 Novoseek inferred chemical compound relationships for THBS2 gene (see all 12)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cerivastatin 45.4 1 12605021 (1)
    tgf beta1 40.9 4 15347840 (3), 9016857 (1)
    procollagen 38 1 1426766 (1)
    vegf 32.5 20 16365183 (6), 10448307 (2), 17107379 (2), 10821491 (1) (see all 5)
    acth 17.6 3 10342868 (2), 12358136 (1)
    oligonucleotide 12.7 1 11563036 (1)
    ganciclovir 10.8 1 10950755 (1)
    heparin 9.04 2 8663244 (1), 1459996 (1)
    thymidine 0 3 9016857 (1), 11723011 (1)
    calcium 0 12 16246837 (5), 17620335 (3), 7798222 (1), 18682400 (1)

    Search CenterWatch for drugs/clinical trials and news about THBS2 / TSP2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for THBS2 gene: 
    NM_003247.3  

    Unigene Cluster for THBS2:

    Thrombospondin 2
    Hs.371147  [show with all ESTs]
    Unigene Representative Sequence: NM_003247
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000366787(uc003qwt.3) ENST00000488355 ENST00000461848 ENST00000472733
    ENST00000435791
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    8/35 QIAGEN miScript miRNA Assays for microRNAs that regulate THBS2 (see all 35):
    hsa-miR-582-3p hsa-miR-3938 hsa-miR-30d hsa-miR-9 hsa-miR-124 hsa-miR-30a hsa-miR-506 hsa-miR-181b
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    Additional mRNA sequence: 

    AK292429.1 BC127845.1 BC146676.1 BC150175.1 BX641023.1 L12350.1 M81339.1 

    14 DOTS entries:

    DT.318423  DT.86854901  DT.97858822  DT.95261122  DT.100792529  DT.86837324  DT.97858821  DT.100792527 
    DT.100792528  DT.100792531  DT.121351011  DT.40224336  DT.75150060  DT.95149447 

    24/320 AceView cDNA sequences (see all 320):

    AL603377 AA953039 AW068385 CA420699 CN483431 BX099356 BX641023 AI753153 
    CB267812 C00154 BU736223 AI750269 CN483550 CA449275 AW581293 BQ940133 
    NM_003247 BU728348 C21348 CA431209 BU627598 AI130835 H88241 AA962069 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for THBS2 (see all 7)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18 ^
    SP1:                    -     -     -                                               -                             -                 -                           
    SP2:                    -     -     -                                                                                                                           
    SP3:                          -     -                                                                                                                           
    SP4:                                -                                                                                                                           
    SP5:                                                                                                                                                            

    ExUns: 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26
    SP1:                                                
    SP2:                                                
    SP3:                                                
    SP4:                                                
    SP5:                                                


    ECgene alternative splicing isoforms for THBS2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    THBS2 expression in normal human tissues (normalized intensities)      THBS2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCAGACTCAG
    THBS2 Expression
    About this image


    THBS2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/26 selected tissues (see all 26) fully expand
     
     Brain (Nervous System)    fully expand to see all 13 entries
             Thalamus
             Human Brain Vascular Smooth Muscle Cells (HBVSMC)   
             Septum   
     
     Bone (Muscoskeletal System)    fully expand to see all 8 entries
             Prechondrocytes Stylopod Epiphyseal End
             Human Calvarial Osteoblasts (HCO)   
     
     Cartilage (Muscoskeletal System)    fully expand to see all 6 entries
             Prechondrocytes Stylopod Epiphyseal End
     
     Heart (Cardiovascular System)    fully expand to see all 5 entries
             Atrioventricular Node Cells Atrioventricular Node
             Coronary Artery Smooth Muscle Cells (CASMC)   
             Cardiac Myocytes   
     
     Fibroblast
             Human Prostate Fibroblasts (HPrF)   

    See THBS2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for THBS2

    SOURCE GeneReport for Unigene cluster: Hs.371147

    UniProtKB/Swiss-Prot: TSP2_HUMAN, P35442
    Tissue specificity: High expression in invertebral disk tissue

        SABiosciences Expression via Pathway-Focused PCR Arrays including THBS2: 
              Lung Cancer in human mouse rat
              Fibrosis in human mouse rat
              Extracellular Matrix & Adhesion Molecules in human mouse rat
              Angiogenesis in human mouse rat

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for THBS2 gene from 5/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Thbs21 , 5 thrombospondin 21, 5 83.92(n)1
    88.64(a)1
      17 (8.95 cM)5
    218261  NM_011581.31  NP_035711.21 
     146655005 
    chicken
    (Gallus gallus)
    Aves THBS21 thrombospondin 2 73.58(n)
    79.59(a)
      414837  NM_001001755.1  NP_001001755.1 
    lizard
    (Anolis carolinensis)
    Reptilia THBS26
    thrombospondin 2
    79(a)
    1 ↔ 1
    1(223967288-224016984)
    zebrafish
    (Danio rerio)
    Actinopterygii thbs2a1 thrombospondin 2a 70.07(n)
    72.03(a)
      794881  XM_001919813.3  XP_001919848.3 
    fruit fly
    (Drosophila melanogaster)
    Insecta Tsp3 cell adhesion molecule 45(a)     --


    ENSEMBL Gene Tree for THBS2 (if available)
    TreeFam Gene Tree for THBS2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for THBS2 gene
    THBS12  THBS42  COMP2  THBS32  
    5 SIMAP similar genes for THBS2 using alignment to 2 protein entries:     TSP2_HUMAN (see all proteins):
    DKFZp686G02190    THBS3    COMP    THBS4    THBS1

    THBS2 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for THBS2
    PGOHUM00000258302


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1465 SNPs in THBS2 are shown (see all 1465)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs732382771,2
    C,F--169615401(+) GCCCGA/GTCGGC 1 -- ds50012Minor allele frequency- G:0.11WA 120
    rs597281971,2
    C--169615416(+) TTTTAG/AGCAGT 1 -- ds50014Minor allele frequency- A:0.09WA NA EA 360
    rs1906896351,2
    C--169615457(+) GGTCCG/TCTACT 1 -- ds50010--------
    rs1410483621,2
    --169615509(+) CAGCTC/TGTATT 1 -- ds50010--------
    rs1468759531,2
    --169615599(+) CCCTCA/GTTTGA 1 -- ds50010--------
    rs1393976201,2
    --169615612(+) ATGAGC/TAGAGG 1 -- ds50010--------
    rs1426925041,2
    C--169615631(+) ATGAAC/TTGCTA 1 -- ds50010--------
    rs725668871,2
    C,F--169615655(+) CACACC/TGTGCT 1 -- ds50011Minor allele frequency- T:0.07EA 120
    rs771500071,2
    C,F--169615656(+) ACACCG/ATGCTG 1 -- ds50011Minor allele frequency- A:0.04NA 120
    rs2004716121,2
    --169615821(+) ACCCC-/TTTCCC 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for THBS2 (169615875 - 169654139 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/18 variations for THBS2 (see all 18):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2662846CNV Deletion23128226
    esv2733482CNV Deletion23290073
    dgv1174e199CNV Deletion23128226
    esv2733483CNV Deletion23290073
    esv2733477CNV Deletion23290073
    esv2733485CNV Deletion23290073
    esv1974260CNV Deletion18987734
    esv2733480CNV Deletion23290073
    esv2733479CNV Deletion23290073
    esv2743386CNV Deletion23290073


    Human Gene Mutation Database (HGMD): THBS2
    SABiosciences Cancer Mutation PCR Assays
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    DNA2.0 Custom Variant and Variant Library Synthesis for THBS2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 188061   
    OMIM disorders: 603932  
    UniProtKB/Swiss-Prot: TSP2_HUMAN, P35442
  • Intervertebral disc disease (IDD) [MIM:603932]: A common musculo-skeletal disorder caused by degeneration
    of intervertebral disks of the lumbar spine. It results in low-back pain and unilateral leg pain. Note=Disease
    susceptibility is associated with variations affecting the gene represented in this entry

  • 20/47 diseases for THBS2 (see all 47):    About MalaCards
    lumbar disc herniation    posterior uveal melanoma    back pain    thoracic aortic aneurysm
    uterine fibroid    gingival overgrowth    ehlers-danlos syndrome    gingivitis
    malignant glioma    cytomegalovirus infection    cervical cancer    malignant mesothelioma
    aortic aneurysm    myocarditis    eclampsia    pre-eclampsia
    myocardial infarction    herpes simplex    coronary heart disease    cervicitis


    THBS2 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014

    10/23 Novoseek inferred disease relationships for THBS2 gene (see all 23)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    neovascularization 36.8 1 19578767 (1)
    carcinoma lewis lung 32.3 1 11929817 (1)
    collagen fibril 29.6 1 12781637 (1)
    tumors 29 59 18955754 (6), 10611308 (4), 11929817 (3), 11712798 (3) (see all 20)
    carcinoma squamous cell 21.4 6 11929817 (1), 11147670 (1), 14675207 (1), 10611308 (1)
    melanoma 20.7 9 12353704 (3), 19082472 (3), 11929817 (1), 9032471 (1) (see all 5)
    glioma 18.9 8 10448307 (4), 17919663 (1), 11132930 (1)
    metastasis 18.7 14 9888480 (3), 18720079 (2), 12353704 (2), 19082472 (2) (see all 5)
    cancer 18.6 3 11147670 (1), 18955754 (1)
    breast carcinoma 14.6 4 9012463 (2), 9032471 (1)

    Genetic Association Database (GAD): THBS2
    Human Genome Epidemiology (HuGE) Navigator: THBS2 (17 documents)

    Export disorders for THBS2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for THBS2 gene, integrated from 9 sources (see all 178):
    (articles sorted by number of sources associating them with THBS2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A functional polymorphism in THBS2 that affects alternative splicing and MMP binding is associated with lumbar-disc herniation. (PubMed id 18455130)1, 2, 3, 4 Hirose Y....Ikegawa S. (2008)
    2. Polymorphisms in thrombospondin genes and myocardial infarction: a case-control study and a meta-analysis of available evidence. (PubMed id 18178577)1, 4, 9 Koch W....Kastrati A. (2008)
    3. Large scale association analysis for identification of genes underlying premature coronary heart disease: cumulative perspective from analysis of 111 candidate genes. (PubMed id 15121769)1, 4, 9 McCarthy J.J....Topol E.J. (2004)
    4. Decreased frequency of the 3'UTR T>G single nucleo tide polymorphism of thrombospondin-2 gene in sudden death due to plaque erosio n. (PubMed id 19631562)1, 4, 9 Burke A....Fowler D. (2009)
    5. Assessment of Genetic Risk Factors for Thoracic Aortic Aneurysm in Hypertensive Patients. (PubMed id 18600213)1, 4, 9 Kato K....Yamada Y. (2008)
    6. Structure of the calcium-rich signature domain of human thrombospondin-2. (PubMed id 16186819)1, 2, 9 Carlson C.B.... Keck J.L. (2005)
    7. Thrombospondin-2 polymorphism is associated with a reduced risk of premature myocardial infarction. (PubMed id 12482844)1, 4, 9 Boekholdt S.M....Reitsma P.H. (2002)
    8. Disulfide connectivity of recombinant C-terminal region of human thrombospondin 2. (PubMed id 11590138)1, 2, 9 Misenheimer T.M.... Mosher D.F. (2001)
    9. Sequence and characterization of the complete human thrombospondin 2 cDNA: potential regulatory role for the 3' untranslated region. (PubMed id 8406456)1, 2, 9 Labell T.L. and Byers P.H. (1993)
    10. Association of common promoter polymorphisms of MCP1 with hepatitis B virus clearance. (PubMed id 17202846)1, 4, 9 Park B.L....Shin H.D. (2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7058 HGNC: 11786 AceView: THBS2 Ensembl:ENSG00000186340 euGenes: HUgn7058
    ECgene: THBS2 Kegg: 7058 H-InvDB: THBS2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for THBS2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for THBS2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for THBS2 gene:
    Search GeneIP for patents involving THBS2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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