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Aliases for THBS2 Gene

Aliases for THBS2 Gene

  • Thrombospondin 2 2 3
  • TSP2 3 4
  • Thrombospondin-2 3

External Ids for THBS2 Gene

Previous GeneCards Identifiers for THBS2 Gene

  • GC06U990123
  • GC06M9S0210
  • GC06M169433
  • GC06M169615
  • GC06M167041

Summaries for THBS2 Gene

Entrez Gene Summary for THBS2 Gene

  • The protein encoded by this gene belongs to the thrombospondin family. It is a disulfide-linked homotrimeric glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. This protein has been shown to function as a potent inhibitor of tumor growth and angiogenesis. Studies of the mouse counterpart suggest that this protein may modulate the cell surface properties of mesenchymal cells and be involved in cell adhesion and migration. [provided by RefSeq, Jul 2008]

GeneCards Summary for THBS2 Gene

THBS2 (Thrombospondin 2) is a Protein Coding gene. Diseases associated with THBS2 include intervertebral disc disease and posterior uveal melanoma. Among its related pathways are PI3K-Akt signaling pathway and Signaling by FGFR. GO annotations related to this gene include calcium ion binding and heparin binding. An important paralog of this gene is THBS4.

UniProtKB/Swiss-Prot for THBS2 Gene

  • Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Ligand for CD36 mediating antiangiogenic properties.

Gene Wiki entry for THBS2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for THBS2 Gene

Genomics for THBS2 Gene

Regulatory Elements for THBS2 Gene

Transcription factor binding sites by QIAGEN in the THBS2 gene promoter:

Genomic Location for THBS2 Gene

Start:
169,215,780 bp from pter
End:
169,254,114 bp from pter
Size:
38,335 bases
Orientation:
Minus strand

Genomic View for THBS2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for THBS2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for THBS2 Gene

Proteins for THBS2 Gene

  • Protein details for THBS2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P35442-TSP2_HUMAN
    Recommended name:
    Thrombospondin-2
    Protein Accession:
    P35442
    Secondary Accessions:
    • A6H8N1
    • A7E232
    • Q5RI52

    Protein attributes for THBS2 Gene

    Size:
    1172 amino acids
    Molecular mass:
    129991 Da
    Quaternary structure:
    • Homotrimer; disulfide-linked. Interacts (via the TSP type I repeats) with CD36; the interaction conveys an antiangiogenic effect. Interacts (via the TSP type I repeats) with HRG; the interaction blocks the antiangiogenic effect of THBS2 with CD36 (By similarity). Can bind to fibrinogen, fibronectin, laminin and type V collagen.

    Three dimensional structures from OCA and Proteopedia for THBS2 Gene

neXtProt entry for THBS2 Gene

Proteomics data for THBS2 Gene at MOPED

Post-translational modifications for THBS2 Gene

  • Glycosylation at Asn151, Thr251, Thr252, Ser259, Asn316, Asn330, Asn457, Asn584, Asn710, and Asn1069
  • Modification sites at PhosphoSitePlus

Other Protein References for THBS2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for THBS2 Gene

Domains for THBS2 Gene

Suggested Antigen Peptide Sequences for THBS2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P35442

UniProtKB/Swiss-Prot:

TSP2_HUMAN :
  • P35442
Domain:
  • Contains 2 EGF-like domains.
  • Contains 1 laminin G-like domain.
  • Contains 1 TSP C-terminal (TSPC) domain.
  • Contains 3 TSP type-1 domains.
  • Contains 1 VWFC domain.
Family:
  • Belongs to the thrombospondin family.
Similarity:
  • Contains 8 TSP type-3 repeats.
genes like me logo Genes that share domains with THBS2: view

No data available for Gene Families for THBS2 Gene

Function for THBS2 Gene

Molecular function for THBS2 Gene

GENATLAS Biochemistry: thrombospondin II,extracellular,glycoprotein expressed in smooth muscle,fibroblast in cell adhesion molecule
UniProtKB/Swiss-Prot Function: Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Ligand for CD36 mediating antiangiogenic properties.

Gene Ontology (GO) - Molecular Function for THBS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IEA --
GO:0005515 protein binding IPI 19818485
GO:0008201 heparin binding IEA --
genes like me logo Genes that share ontologies with THBS2: view
genes like me logo Genes that share phenotypes with THBS2: view

Animal Models for THBS2 Gene

MGI Knock Outs for THBS2:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for THBS2 Gene

Localization for THBS2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for THBS2 Gene COMPARTMENTS Subcellular localization image for THBS2 gene
Compartment Confidence
extracellular 4
cytosol 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for THBS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005604 basement membrane IEA --
GO:0031012 extracellular matrix --
GO:0031091 platelet alpha granule IDA 1737102
genes like me logo Genes that share ontologies with THBS2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for THBS2 Gene

Pathways for THBS2 Gene

genes like me logo Genes that share pathways with THBS2: view

Pathways by source for THBS2 Gene

1 Qiagen pathway for THBS2 Gene
1 BioSystems pathway for THBS2 Gene
2 Reactome pathways for THBS2 Gene
1 R&D Systems pathway for THBS2 Gene

Gene Ontology (GO) - Biological Process for THBS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion IEA --
GO:0016525 negative regulation of angiogenesis IDA 20714802
GO:0051965 positive regulation of synapse assembly IEA --
genes like me logo Genes that share ontologies with THBS2: view

Compounds for THBS2 Gene

(12) Novoseek inferred chemical compound relationships for THBS2 Gene

Compound -log(P) Hits PubMed IDs
cerivastatin 45.4 1
tgf beta1 40.9 4
procollagen 38 1
vegf 32.5 12
acth 17.6 3
genes like me logo Genes that share compounds with THBS2: view

Transcripts for THBS2 Gene

Unigene Clusters for THBS2 Gene

Thrombospondin 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for THBS2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18 ^
SP1: - - - - - -
SP2: - - -
SP3: - -
SP4: -
SP5:
SP6:
SP7:

ExUns: 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:

Relevant External Links for THBS2 Gene

GeneLoc Exon Structure for
THBS2
ECgene alternative splicing isoforms for
THBS2

Expression for THBS2 Gene

mRNA expression in normal human tissues for THBS2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for THBS2 Gene

This gene is overexpressed in Artery - Aorta (9.9) and Artery - Coronary (7.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for THBS2 Gene

SOURCE GeneReport for Unigene cluster for THBS2 Gene Hs.371147

mRNA Expression by UniProt/SwissProt for THBS2 Gene

P35442-TSP2_HUMAN
Tissue specificity: High expression in invertebral disk tissue.
genes like me logo Genes that share expressions with THBS2: view

Orthologs for THBS2 Gene

This gene was present in the common ancestor of animals.

Orthologs for THBS2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia THBS2 35
  • 94.37 (n)
  • 93.17 (a)
cow
(Bos Taurus)
Mammalia THBS2 35
  • 85.64 (n)
  • 90.48 (a)
THBS2 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia THBS2 35
  • 86.91 (n)
  • 91.46 (a)
THBS2 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Thbs2 35
  • 83.92 (n)
  • 88.64 (a)
Thbs2 16
Thbs2 36
  • 89 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia THBS2 36
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia THBS2 36
  • 84 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Thbs2 35
  • 83.4 (n)
  • 88.47 (a)
chicken
(Gallus gallus)
Aves THBS2 35
  • 73.58 (n)
  • 79.59 (a)
THBS2 36
  • 77 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia THBS2 36
  • 79 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia thbs2 35
  • 70.23 (n)
  • 75.96 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6394 35
zebrafish
(Danio rerio)
Actinopterygii LOC100535241 35
  • 69.93 (n)
  • 71.7 (a)
thbs2a 36
  • 71 (a)
OneToMany
thbs2a 36
  • 71 (a)
OneToMany
thbs2b 36
  • 69 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Tsp 36
  • 37 (a)
OneToMany
Tsp 37
  • 45 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 50 (a)
OneToMany
Species with no ortholog for THBS2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for THBS2 Gene

ENSEMBL:
Gene Tree for THBS2 (if available)
TreeFam:
Gene Tree for THBS2 (if available)

Paralogs for THBS2 Gene

Paralogs for THBS2 Gene

Selected SIMAP similar genes for THBS2 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for THBS2 Gene

genes like me logo Genes that share paralogs with THBS2: view

Variants for THBS2 Gene

Sequence variations from dbSNP and Humsavar for THBS2 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs1003 -- 169,216,342(-) TAGTA(A/G)GAGAA utr-variant-3-prime
rs1040 -- 169,216,252(-) GGAAC(A/G)ATCCA utr-variant-3-prime
rs1041 -- 169,216,332(-) AGTCT(A/G)TCTGT utr-variant-3-prime
rs1042 -- 169,216,236(-) TTAGT(C/T)TTAAT utr-variant-3-prime
rs3253 -- 169,216,017(-) TGGGA(A/G)TGACG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for THBS2 Gene

Variant ID Type Subtype PubMed ID
dgv7047n71 CNV Gain 21882294
dgv7048n71 CNV Loss 21882294
esv2733477 CNV Deletion 23290073
esv2733479 CNV Deletion 23290073
esv2662846 CNV Deletion 23128226
esv2733480 CNV Deletion 23290073
esv1974260 CNV Deletion 18987734
nsv887008 CNV Loss 21882294
nsv5597 CNV Loss 18451855
esv28652 CNV Loss 19812545
nsv820425 CNV Duplication 20802225
dgv1174e199 CNV Deletion 23128226
esv2733481 CNV Deletion 23290073
esv6700 CNV Loss 19470904
esv2733482 CNV Deletion 23290073
esv2743386 CNV Deletion 23290073
esv2733483 CNV Deletion 23290073
esv2733485 CNV Deletion 23290073

Relevant External Links for THBS2 Gene

HapMap Linkage Disequilibrium report
THBS2
Human Gene Mutation Database (HGMD)
THBS2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for THBS2 Gene

Disorders for THBS2 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for THBS2 Gene including...

Search for THBS2 Gene in MalaCards »

(1) OMIM Diseases for THBS2 Gene (188061)

UniProtKB/Swiss-Prot

TSP2_HUMAN
  • Intervertebral disc disease (IDD) [MIM:603932]: A common musculo-skeletal disorder caused by degeneration of intervertebral disks of the lumbar spine. It results in low-back pain and unilateral leg pain. {ECO:0000269 PubMed:18455130}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

(23) Novoseek inferred disease relationships for THBS2 Gene

Disease -log(P) Hits PubMed IDs
neovascularization 36.8 1
carcinoma lewis lung 32.3 1
collagen fibril 29.6 1
tumors 29 35
carcinoma squamous cell 21.4 4

Relevant External Links for THBS2

Genetic Association Database (GAD)
THBS2
Human Genome Epidemiology (HuGE) Navigator
THBS2
genes like me logo Genes that share disorders with THBS2: view

Publications for THBS2 Gene

  1. A functional polymorphism in THBS2 that affects alternative splicing and MMP binding is associated with lumbar-disc herniation. (PMID: 18455130) Hirose Y. … Ikegawa S. (Am. J. Hum. Genet. 2008) 2 3 4 48
  2. Large scale association analysis for identification of genes underlying premature coronary heart disease: cumulative perspective from analysis of 111 candidate genes. (PMID: 15121769) McCarthy J.J. … Topol E.J. (J. Med. Genet. 2004) 3 23 48
  3. Polymorphisms in thrombospondin genes and myocardial infarction: a case-control study and a meta-analysis of available evidence. (PMID: 18178577) Koch W. … Kastrati A. (Hum. Mol. Genet. 2008) 3 23 48
  4. Association of common promoter polymorphisms of MCP1 with hepatitis B virus clearance. (PMID: 17202846) Park B.L. … Shin H.D. (Exp. Mol. Med. 2006) 3 23 48
  5. Assessment of genetic risk factors for thoracic aortic aneurysm in hypertensive patients. (PMID: 18600213) Kato K. … Yamada Y. (Am. J. Hypertens. 2008) 3 23 48

Products for THBS2 Gene

Sources for THBS2 Gene

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