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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

THBS1 Gene

protein-coding GIFtS: 68
GCID: GC15P039873

thrombospondin 1

Explore 167 diseases affiliated with
THBS1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Thrombospondin 1¹ ²		THBS-1¹ ²
TSP¹ ² ³		TSP-1¹ ²
TSP1¹ ² ³		Thrombospondin-1¹
THBS¹ ²		Thrombospondin-1p180¹

External Ids:	HGNC: 11785¹	Entrez Gene: 7057²	Ensembl: ENSG00000137801⁷	OMIM: 188060⁵	UniProtKB: P07996³

Export aliases for THBS1 gene to outside databases

Previous GC identifers: GC15P035240 GC15P032769 GC15P037452 GC15P037589 GC15P037660 GC15P016716

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for THBS1:

The protein encoded by this gene is a subunit of a disulfide-linked homotrimeric protein. This protein is an adhesive

glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. This protein can bind to fibrinogen,

fibronectin, laminin, type V collagen and integrins alpha-V/beta-1. This protein has been shown to play roles in

platelet aggregation, angiogenesis, and tumorigenesis. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: TSP1_HUMAN, P07996

Function: Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Binds heparin. May play a

role in dentinogenesis and/or maintenance of dentin and dental pulp (By similarity). Ligand for CD36 mediating

antiangiogenic properties

Gene Wiki entry for THBS1 (Thrombospondin 1)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000015.9 NC_018926.1 NT_010194.17

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the THBS1 gene promoter:
CREB PPAR-gamma1 deltaCREB MyoD GR-alpha PPAR-gamma2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: THBS1 promoter sequence

Search SABiosciences Chromatin IP Primers for THBS1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat THBS1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q15 Ensembl cytogenetic band: 15q14 HGNC cytogenetic band: 15q15

THBS1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
THBS1 gene location

GeneLoc information about chromosome 15 GeneLoc Exon Structure

GeneLoc location for GC15P039873: view genomic region (about GC identifiers)

Start:	39,873,280 bp from pter	End:	39,891,667 bp from pter
Size:	18,388 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: TSP1_HUMAN, P07996 (See protein sequence)

Recommended Name: Thrombospondin-1 precursor

Size: 1170 amino acids; 129383 Da

Subunit: Homotrimer; disulfide-linked. Interacts (via the TSP type I repeats) with HRG; the interaction blocks the

antiangiogenic effect of THBS1 with CD36 (By similarity). Can bind to fibrinogen, fibronectin, laminin, type V

collagen and integrins alpha-V/beta-1, alpha-V/beta-3 and alpha-IIb/beta-3. Interacts (via the TSP type I repeats)

with CD36; the interaction conveys an antiangiogenic effect

6/9 PDB 3D structures from and Proteopedia for THBS1 (see all 9):

1LSL (3D)

1UX6 (3D)

1Z78 (3D)

1ZA4 (3D)

2ERF (3D)

2ES3 (3D)

Secondary accessions: A8K6H4 B9EGH6 Q15667

Explore the universe of human proteins at neXtProt for THBS1: NX_P07996

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P07996

THBS1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_003237.2

ENSEMBL proteins:

ENSP00000380720 ENSP00000260356

Reactome Protein details: P07996
Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
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	Novus Biologicals THBS1 Proteins Novus Biologicals THBS1 Lysates
	Browse Sino Biological Recombinant Proteins
	ProSpec Recombinant Protein for THBS1
	Uscn Proteins for THBS1

Gene Ontology (GO): 5/9 cellular component terms (GO ID links to tree view) (see all 9): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	TAS	--
GO:0005577	fibrinogen complex	IDA	3997886
GO:0005615	extracellular space	IDA	--
GO:0009897	external side of plasma membrane	IDA	6777381
GO:0030141	secretory granule	IDA	101549

THBS1 for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for THBS1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

THBS1 for domains About GeneDecksing

5/11 InterPro domains/families (see all 11):

IPR000884 Thrombospondin_1_rpt

IPR001881 EGF-like_Ca-bd

IPR000742 EG-like_dom

IPR013320 ConA-like_subgrp

IPR001791 Laminin_G

Graphical View of Domain Structure for InterPro Entry P07996

ProtoNet protein and cluster: P07996

5/7 Blocks protein families (see all 7):

IPB000884 Thrombospondin

IPB001007 von Willebrand factor

IPB001881 EGF-like calcium-binding

IPB003129 Thrombospondin

IPB006210 Type I EGF

UniProtKB/Swiss-Prot: TSP1_HUMAN, P07996

Similarity: Belongs to the thrombospondin family

Similarity: Contains 2 EGF-like domains

Similarity: Contains 1 laminin G-like domain

Similarity: Contains 1 TSP C-terminal (TSPC) domain

Similarity: Contains 3 TSP type-1 domains

Similarity: Contains 8 TSP type-3 repeats

Similarity: Contains 1 VWFC domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: TSP1_HUMAN, P07996

Function: Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Binds heparin. May play a

role in dentinogenesis and/or maintenance of dentin and dental pulp (By similarity). Ligand for CD36 mediating

antiangiogenic properties

Genatlas biochemistry entry for THBS1:

thrombospondin I (140kDa),glycoprotein expressed in extracellular matrix protein involved in platelet

aggregation,embryogenesis,morphogenesis,cell adhesion molecule,major activator of TGFB1

miRNA Products:		miRTarBase miRNAs that target THBS1: hsa-mir-1 (MIRT001328), hsa-mir-20a (MIRT005627), hsa-mir-30a (MIRT001763), hsa-let-7b (MIRT001586), hsa-mir-17 (MIRT005626), hsa-mir-92a (MIRT005628), hsa-let-7a (MIRT004958), hsa-mir-98 (MIRT004943)

		OriGene 3'-UTR Clone: THBS1 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat THBS1
		8/40 QIAGEN miScript miRNA Assays for microRNAs that regulate THBS1 (see all 40):
		hsa-let-7d hsa-miR-139-5p hsa-let-7g hsa-let-7a hsa-miR-3148 hsa-miR-2113 hsa-miR-3163 hsa-miR-4264

		SwitchGear 3'UTR luciferase reporter plasmid: THBS1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for THBS1 (see all 7) OriGene shRNA RFP: THBS1 OriGene siRNA: THBS1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat THBS1

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for THBS1

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		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for THBS1 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for THBS1 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: THBS1 (NM_003246)
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		Search LifeMap BioReagents cell lines for THBS1

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for THBS1

Gene Ontology (GO): 5/17 molecular function terms (GO ID links to tree view) (see all 17): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001786	phosphatidylserine binding	IDA	18940719
GO:0001948	glycoprotein binding	NAS	6438154
GO:0001968	fibronectin binding	IDA	6693501
GO:0005178	integrin binding	IMP	18757424
GO:0005509	calcium ion binding	NAS	9304800

THBS1 for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for THBS1:

Decreased TP53 protein express

Animal Models:
Mouse knock-out Thbs1^tm1Hyn for THBS1
15/19 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Thbs1) (see all 19):

cardiovascular system	cellular	digestive/alimentary	endocrine/exocrine gland	growth/size
hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail
liver/biliary system	mortality/aging	muscle	renal/urinary system	reproductive system

THBS1 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/20 super-pathways (see all 20) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Platelet activation, signaling and aggregation

Platelet activation, signaling and aggregation

1.00

Hemostasis

0.43

Platelet degranulation

Platelet degranulation

1.00

Response to elevated platelet cytosolic Ca2+

0.94

ECM-receptor interaction

ECM-receptor interaction

1.00

Integrin cell surface interactions

0.32

Focal Adhesion

Focal Adhesion

1.00

Focal adhesion

0.66

Integrated Pancreatic Cancer Pathway

Integrated Pancreatic Cancer Pathway

1.00

Integrated Pancreatic Cancer Pathway

0.99

Pathway sources
See GeneCards unified pathways
Show all pathways

2 EMD Millipore Pathways for THBS1

	Selected targets of ESR1
	Selected targets of p53

2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for THBS1

	Inhibition of Angiogenesis by TSP1
	p53 Signaling

5/7 BioSystems Pathways for THBS1 (see all 7)

	Focal Adhesion
	Senescence and Autophagy
	TGF Beta Signaling Pathway
	Integrated Pancreatic Cancer Pathway
	Integrated Pancreatic Cancer Pathway

5/7 Reactome Pathways for THBS1 (see all 7)

	Hemostasis
	Integrin cell surface interactions
	Platelet degranulation
	Signal Transduction
	Signaling by PDGF

5/7 Kegg Pathways (Kegg details for THBS1) (see all 7):

	p53 signaling pathway
	Phagosome
	TGF-beta signaling pathway
	Focal adhesion
	ECM-receptor interaction

THBS1 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for THBS1

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/81 Interacting proteins for THBS1 (P07996^{2, 3} ENSP00000260356⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 81)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
IGFBP5	P24593³, ENSP00000233813⁴	I2D: score=4 STRING: ENSP00000233813
COL1A1	P02452³, ENSP00000225964⁴	I2D: score=3 STRING: ENSP00000225964
COL3A1	P02461³, ENSP00000304408⁴	I2D: score=3 STRING: ENSP00000304408
FN1	P02751³, ENSP00000346839⁴	I2D: score=3 STRING: ENSP00000346839
LRP1	Q07954³, ENSP00000243077⁴	I2D: score=3 STRING: ENSP00000243077

About this table

Gene Ontology (GO): 5/59 biological process terms (GO ID links to tree view) (see all 59): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000187	activation of MAPK activity	IMP	17413041
GO:0001666	response to hypoxia	NAS	9304800
GO:0001937	negative regulation of endothelial cell proliferation	IMP	17413041
GO:0001953	negative regulation of cell-matrix adhesion	IDA	17416590
GO:0002040	sprouting angiogenesis	IMP	17879962

THBS1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

THBS1 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for THBS1
10/103 Novoseek chemical compound relationships for THBS1 gene (see all 103) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
vegf	74.6	341	11856116 (9), 19762163 (7), 12963968 (6), 18788631 (6) (see all 99)
grgdsp	60.4	7	9362073 (1), 7695484 (1), 7519904 (1), 9351379 (1) (see all 6)
heparin	51.7	128	1703153 (9), 10222132 (7), 18940719 (6), 14517432 (4) (see all 45)
grgesp	47	3	9351379 (1), 7737404 (1)
dauricine	45.4	6	10678148 (2), 11477827 (1)
tgf beta1	45	22	11955611 (5), 16100902 (4), 15347840 (3), 14583181 (2) (see all 7)
matrigel	44.3	3	17704650 (1), 9489491 (1), 19158196 (1), 10398144 (1)
fibrinogen	43.1	81	11094060 (8), 1309961 (3), 7693024 (3), 7947604 (2) (see all 28)
grgds	42.4	5	1873028 (2), 8305744 (1), 1716458 (1), 7518179 (1)
procollagen	39.4	8	11016937 (3), 1426766 (2), 11691800 (1), 10391381 (1)

Search CenterWatch for drugs/clinical trials and news about THBS1 / TSP1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for THBS1 gene:

NM_003246.2

Unigene Cluster for THBS1:

Thrombospondin 1

Hs.164226 [show with all ESTs]

Unigene Representative Sequence: NM_003246

9 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000397591 ENST00000260356(uc001zkh.3 uc010bbi.3) ENST00000478845

ENST00000497720 ENST00000466755 ENST00000490247 ENST00000560894 ENST00000484734

ENST00000559746

miRNA Products:		OriGene 3'-UTR Clone: THBS1 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat THBS1
		8/40 QIAGEN miScript miRNA Assays for microRNAs that regulate THBS1 (see all 40):
		hsa-let-7d hsa-miR-139-5p hsa-let-7g hsa-let-7a hsa-miR-3148 hsa-miR-2113 hsa-miR-3163 hsa-miR-4264

		SwitchGear 3'UTR luciferase reporter plasmid: THBS1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat THBS1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat THBS1

Additional cDNA sequence:

AB209912.1 AK291639.1 AK293230.1 AK304754.1 AK309613.1 AK310820.1 BC028145.1 BC136469.1

BC136470.1 M14326.1 M25631.1 M99425.1 X04665.1 X14787.1

24/33 DOTS entries (see all 33):

DT.95317311 DT.100877416 DT.451114 DT.110480 DT.100877417 DT.100823315 DT.70104615 DT.91873884

DT.121037763 DT.91765697 DT.121037756 DT.121037716 DT.86836637 DT.100823317 DT.121037762 DT.100751785

DT.121637399 DT.40244713 DT.95371378 DT.91765704 DT.92009463 DT.121037724 DT.121037736 DT.121037766

24/563 AceView cDNA sequences (see all 563):

C01864 CA952498 AI492979 AA232790 BP337099 AA343622 BP363183 BF058799

BF430952 BP363916 BG413413 AW997017 BQ014354 AI168683 BX474156 AL703097

AI755232 BP354076 BQ019617 BG952002 CF272424 BP358277 AV660617 BP364427

GeneLoc Exon Structure

5/6 Alternative Splicing Database (ASD) splice patterns (SP) for THBS1 (see all 6) About this scheme

ExUns:	1a	·	1b	^	2a	·	2b	^	3a	·	3b	^	4	^	5	^	6	^	7	^	8a	·	8b	·	8c	^	9a	·	9b	^	10a	·	10b	^	11	^	12	^	13	^	14	^	15a	·	15b	^	16	^	17	^	18a	·
SP1:					-																-								-														-
SP2:
SP3:																													-
SP4:
SP5:

ExUns:	18b	^	19a	·	19b	^	20	^	21	^	22
SP1:					-
SP2:
SP3:
SP4:
SP5:

ECgene alternative splicing isoforms for THBS1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

THBS1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AGGTCTTCAA

About this image

THBS1 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

10/19 LifeMap In Vivo Development Anatomical Compartments/Cells (see all 19)

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Tendons & Ligaments

Axial Tendons and Ligamnets

Tenocytes

Selective marker (cell-identifying gene)

Tendons & Ligaments

Limb Tendons and Ligamnets

Tenocytes

Tendons & Ligaments

Adipose

Visceral White Adipose

Visceral White Adipocytes

Adipose

Epicardium

Respiratory Bronchioles

Basal Cells

Lung

Bone

Rostral Endochondral Facial Bones

Bone

Rostral Skull Membranous Bones

Bone

Brain

Brain

Brain

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 3 LifeMap Cells

Name

Category

PureStem™ progenitor T36 (Embryonic Progenitor Cell)

Posterior foregut-like cells (A scalable, suspensi...)

Epiblast-like cells (Reconstitution of mo...)

See THBS1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for THBS1

SOURCE GeneReport for Unigene cluster: Hs.164226

SABiosciences Expression via Pathway-Focused PCR Arrays including THBS1 (see all 12):

Fibrosis in human mouse rat

Extracellular Matrix & Adhesion Molecules in human mouse rat

Angiogenic Growth Factors in human mouse rat

TGFB/BMP Signaling Pathway in human mouse rat

Angiogenesis in human mouse rat

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat THBS1

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for THBS1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for THBS1 gene from 4/16 species (see all 16) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	THBS1¹	thrombospondin 1	78.9(n) 85.96(a)		373987 NM_001199453.1 NP_001186382.1
lizard (Anolis carolinensis)	Reptilia	THBS1⁶	--	86(a)	1 ↔ 1	GL343264.1(1927571-1932401)
African clawed frog (Xenopus laevis)	Amphibia	L04278.1²	--	76.71(n)		L04278.1
zebrafish (Danio rerio)	Actinopterygii	AI877511.1²	--	75.58(n)		324926 AI877511.1

ENSEMBL Gene Tree for THBS1 (if available)
TreeFam Gene Tree for THBS1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for THBS1 gene

THBS4² COMP² THBS3² THBS2²

5 SIMAP similar genes for THBS1 using alignment to 3 protein entries: TSP1_HUMAN (see all proteins):

DKFZp686G02190 THBS3 COMP THBS4 THBS2

THBS1 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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SNP ID	Valid	Clinical significance	Chr 15 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs12324889^1,2	C,	--	39871308(+)	`GTGAGT/CGCTGG`	1	--	us2k¹		2		CSA WA	120
rs187184969^1,2		--	39871518(+)	`TGGAAA/GGAAGA`	1	--	us2k¹		0	--	--	--	--
rs112115280^1,2		--	39871630(+)	`TGCTTG/CGATGA`	1	--	us2k¹		2		CSA WA	120
rs192480490^1,2		--	39871650(+)	`TATGAC/TTTGCG`	1	--	us2k¹		0	--	--	--	--
rs139822095^1,2	C,	--	39871813(+)	`GTAAT-/ACACACA`	1	--	us2k¹		0	--	--	--	--
rs72093362^1,2	C,	--	39871814(+)	`GTAAT-/ACAC ACACA`	1	--	us2k¹		0	--	--	--	--
rs71309409^1,2	C	--	39871841(-)	`AGATGGT/-GTGTG`	1	--	us2k¹		1		NA	2
rs114056845^1,2	F,	--	39871902(+)	`GTAAAC/AACTTG`	1	--	us2k¹		1		WA	118
rs142362851^1,2		--	39871928(+)	`CGGGAC/GTCCTG`	1	--	us2k¹		0	--	--	--	--
rs61464827^1,2	C,F,	--	39872038(+)	`GGAGCG/CAGCCC`	1	--	us2k¹		4		NA CSA WA	428

HapMap Linkage Disequilibrium report for THBS1 (39873280 - 39891667 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for THBS1: --
Human Gene Mutation Database (HGMD): THBS1

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing THBS1

DNA2.0 Custom Variant and Variant Library Synthesis for THBS1

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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THBS1 for disorders           About GeneDecksing

OMIM gene information: 188060    OMIM disorders: --

20/167 diseases for THBS1 (see all 167):    About MalaCards

glanzmann's thrombasthenia thrombotic thrombocytopenic purpura proliferative diabetic retinopathy focal segmental glomerulosclerosis

inclusion body myositis corneal neovascularization non-small cell lung carcinoma posterior uveal melanoma

leiomyomatosis and renal cell cancer critical limb ischemia hereditary leiomyomatosis and renal cell cancer diabetic retinopathy

leiomyomatosis pilocytic astrocytoma thrombasthenia testicular germ cell tumor

malignant pleural mesothelioma type 2 diabetes mellitus idiopathic interstitial pneumonia hemorrhagic fever

2 diseases from the University of Copenhagen DISEASES database for THBS1:

Cancer Vascular disease

10/98 Novoseek disease relationships for THBS1 gene (see all 98) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
purpura thrombotic thrombocytopenic	66.3	8	17367414 (1), 16204318 (1), 16831327 (1), 15890682 (1) (see all 8)
neovascularization	64	32	19080117 (5), 19024308 (2), 8780385 (1), 12719977 (1) (see all 19)
tumors	62.5	730	9017002 (10), 10375104 (8), 11712798 (7), 8093068 (6) (see all 99)
metastasis	51.5	114	17709727 (3), 10427124 (3), 12429967 (3), 7527299 (3) (see all 58)
cancer	48.3	143	9600434 (4), 10650779 (3), 10427124 (3), 16204059 (3) (see all 76)
skin carcinoma	47.8	3	9833775 (1), 10051595 (1), 9365532 (1)
corneal neovascularization	45.1	2	11134179 (1), 12714043 (1)
ductal breast carcinoma	41.4	3	9012463 (1), 12814189 (1), 7511188 (1)
melanoma	40.3	70	12447621 (6), 7599038 (4), 9679984 (4), 9618039 (3) (see all 28)
blood vessel tumors	39.9	1	10595934 (1)

Genetic Association Database (GAD): THBS1
Human Genome Epidemiology (HuGE) Navigator: THBS1 (26 documents)

Export disorders for THBS1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for THBS1 gene, integrated from 9 sources (see all 1153):
(articles sorted by number of sources associating them with THBS1)

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Genetic association analysis of myocardial infarction with thrombospondin-1 N700S variant in a Chinese population. (PubMed id 15140581)^{1, 4, 9} Zhou X....Gu D. (2004)
[Correlation of thrombospondin-1 G1678A polymorphism to stroke: a study in Chinese population] (PubMed id 15730804)^{1, 4, 9} Liu X.N....Hui R.T. (2004)
Biophysical characterization, including disulfide bond assignments, of the anti-angiogenic type 1 domains of human thrombospondin-1. (PubMed id 12450399)^{1, 2, 9} Huwiler K.G.... Mosher D.F. (2002)
Crystal structure of the TSP-1 type 1 repeats: a novel layered fold and its biological implication. (PubMed id 12391027)^{1, 2, 9} Tan K....Wang J.H. (2002)
Histidine-rich glycoprotein inhibits the antiangiogenic effect of thrombospondin-1. (PubMed id 11134179)^{1, 2, 9} Simantov R....Silverstein R.L. (2001)
Structure and chromosomal localization of the human thrombospondin gene. (PubMed id 2341158)^{1, 3, 9} Wolf F.W....Dixit V.M. (1990)
Elucidation of N-glycosylation sites on human platelet proteins: a glycoproteomic approach. (PubMed id 16263699)^{1, 2} Lewandrowski U.... Sickmann A. (2006)
Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry. (PubMed id 16740002)^{1, 2} Ramachandran P....Loo J.A. (2006)
Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PubMed id 16335952)^{1, 2} Liu T.... Smith R.D. (2005)
Structure of a thrombospondin C-terminal fragment reveals a novel calcium core in the type 3 repeats. (PubMed id 15014436)^{1, 2} Kvansakul M.... Hohenester E. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 7057	HGNC: 11785	AceView: THBS1	Ensembl:ENSG00000137801	euGenes: HUgn7057
ECgene: THBS1	Kegg: 7057	H-InvDB: THBS1

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for THBS1	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for THBS1	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for THBS1 gene
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Patent Information for THBS1 gene:
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GeneCards and IP:
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