Aliases for THBS1 Gene
External Ids for THBS1 Gene
Previous GeneCards Identifiers for THBS1 Gene
The protein encoded by this gene is a subunit of a disulfide-linked homotrimeric protein. This protein is an adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. This protein can bind to fibrinogen, fibronectin, laminin, type V collagen and integrins alpha-V/beta-1. This protein has been shown to play roles in platelet aggregation, angiogenesis, and tumorigenesis. [provided by RefSeq, Jul 2008]
GeneCards Summary for THBS1 Gene
THBS1 (Thrombospondin 1) is a Protein Coding gene. Diseases associated with THBS1 include Thrombotic Thrombocytopenic Purpura and Babesiosis. Among its related pathways are Interleukin-3, 5 and GM-CSF signaling and Diseases associated with O-glycosylation of proteins. GO annotations related to this gene include calcium ion binding and heparin binding. An important paralog of this gene is THBS2.
UniProtKB/Swiss-Prot for THBS1 Gene
Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Binds heparin. May play a role in dentinogenesis and/or maintenance of dentin and dental pulp (By similarity). Ligand for CD36 mediating antiangiogenic properties. Plays a role in ER stress response, via its interaction with the activating transcription factor 6 alpha (ATF6) which produces adaptive ER stress response factors (By similarity).