Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



THBS1 Gene

protein-coding   GIFtS: 71
GCID: GC15P039873

Thrombospondin 1

  See THBS1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Thrombospondin 11 2     THBS2
thrombospondin-1p1801 2     THBS-12
TSP2 3     TSP-12
TSP12 3     thrombospondin-12

External Ids:    HGNC: 117851   Entrez Gene: 70572   Ensembl: ENSG000001378017   OMIM: 1880605   UniProtKB: P079963   

Export aliases for THBS1 gene to outside databases

Previous GC identifers: GC15P035240 GC15P032769 GC15P037452 GC15P037589 GC15P037660 GC15P016716


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for THBS1 Gene:
The protein encoded by this gene is a subunit of a disulfide-linked homotrimeric protein. This protein is an
adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. This protein can bind to
fibrinogen, fibronectin, laminin, type V collagen and integrins alpha-V/beta-1. This protein has been shown to
play roles in platelet aggregation, angiogenesis, and tumorigenesis. (provided by RefSeq, Jul 2008)

GeneCards Summary for THBS1 Gene:
THBS1 (thrombospondin 1) is a protein-coding gene. Diseases associated with THBS1 include hereditary leiomyomatosis and renal cell cancer, and gastric cardia adenocarcinoma. GO annotations related to this gene include heparin binding and calcium ion binding. An important paralog of this gene is THBS4.

UniProtKB/Swiss-Prot: TSP1_HUMAN, P07996
Function: Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Binds heparin. May
play a role in dentinogenesis and/or maintenance of dentin and dental pulp (By similarity). Ligand for CD36
mediating antiangiogenic properties. Plays a role in ER stress response, via its interaction with the activating
transcription factor 6 alpha (ATF6) which produces adaptive ER stress response factors (By similarity)

Gene Wiki entry for THBS1 (Thrombospondin 1) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000015.9  NC_018926.2  NT_010194.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the THBS1 gene promoter:
         CREB   PPAR-gamma1   deltaCREB   MyoD   GR-alpha   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTHBS1 promoter sequence
   Search Chromatin IP Primers for THBS1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat THBS1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q15   Ensembl cytogenetic band:  15q14   HGNC cytogenetic band: 15q15

THBS1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
THBS1 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15P039873:  view genomic region     (about GC identifiers)

Start:
39,873,280 bp from pter      End:
39,891,667 bp from pter
Size:
18,388 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: TSP1_HUMAN, P07996 (See protein sequence)
Recommended Name: Thrombospondin-1 precursor  
Size: 1170 amino acids; 129383 Da
Subunit: Homotrimer; disulfide-linked. Interacts (via the TSP type I repeats) with HRG; the interaction blocks the
antiangiogenic effect of THBS1 with CD36 (By similarity). Can bind to fibrinogen, fibronectin, laminin, type V
collagen and integrins alpha-V/beta-1, alpha-V/beta-3 and alpha-IIb/beta-3. Interacts (via the TSP type I
repeats) with CD36; the interaction conveys an antiangiogenic effect. Interacts with ATF6 (via lumenal domain)
(By similarity)
Selected PDB 3D structures from and Proteopedia for THBS1 (see all 9):
1LSL (3D)        1UX6 (3D)        1Z78 (3D)        1ZA4 (3D)        2ERF (3D)        2ES3 (3D)    
Secondary accessions: A8K6H4 B9EGH6 Q15667

Explore the universe of human proteins at neXtProt for THBS1: NX_P07996

Explore proteomics data for THBS1 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn248, Thr289, Thr292, Thr293, Thr302, Asn360, Trp385, Ser394, Trp438, Trp441,
                                 Thr450, Trp498, Thr507, Thr638, Asn708, Asn1067
  • Modification sites at PhosphoSitePlus

  • See THBS1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_003237.2  
    ENSEMBL proteins: 
     ENSP00000380720   ENSP00000260356  
    Reactome Protein details: P07996

    THBS1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for THBS1 (Thrombospondin-1)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for THBS1
    OriGene Protein Over-expression Lysate for THBS1
    OriGene MassSpec for THBS1
    OriGene Custom Protein Services for THBS1
    GenScript Custom Purified and Recombinant Proteins Services for THBS1
    Novus Biologicals THBS1 Proteins
    Novus Biologicals THBS1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for THBS1
    Cloud-Clone Corp. Proteins for THBS1

     
    Search eBioscience for Proteins for THBS1 

     
    antibodies-online proteins for THBS1 (19 products) 

     
    antibodies-online peptides for THBS1

    THBS1 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for THBS1 (Thrombospondin-1)
    OriGene Antibodies for THBS1
    OriGene Custom Antibody Services for THBS1
    Novus Biologicals THBS1 Antibodies
    Abcam antibodies for THBS1
    Cloud-Clone Corp. Antibodies for THBS1
    ThermoFisher Antibody for THBS1
    antibodies-online antibodies for THBS1 (121 products) 

    THBS1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for THBS1
    R&D Systems ELISAs for THBS1 (Thrombospondin-1)         (see all)
    GenScript Custom Assay Services for THBS1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for THBS1
    Cloud-Clone Corp. CLIAs for THBS1
    Search eBioscience for ELISAs for THBS1 
    antibodies-online kits for THBS1 (29 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    Selected InterPro protein domains (see all 12):
     IPR000884 Thrombospondin_1_rpt
     IPR001881 EGF-like_Ca-bd_dom
     IPR000742 EG-like_dom
     IPR013320 ConA-like_subgrp
     IPR001791 Laminin_G

    Graphical View of Domain Structure for InterPro Entry P07996

    ProtoNet protein and cluster: P07996

    Selected Blocks protein domains (see all 7):
    IPB000884 Thrombospondin
    IPB001007 von Willebrand factor
    IPB001881 EGF-like calcium-binding
    IPB003129 Thrombospondin
    IPB006210 Type I EGF


    UniProtKB/Swiss-Prot: TSP1_HUMAN, P07996
    Similarity: Belongs to the thrombospondin family
    Similarity: Contains 2 EGF-like domains
    Similarity: Contains 1 laminin G-like domain
    Similarity: Contains 1 TSP C-terminal (TSPC) domain
    Similarity: Contains 3 TSP type-1 domains
    Similarity: Contains 8 TSP type-3 repeats
    Similarity: Contains 1 VWFC domain


    Find genes that share domains with THBS1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TSP1_HUMAN, P07996
    Function: Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Binds heparin. May
    play a role in dentinogenesis and/or maintenance of dentin and dental pulp (By similarity). Ligand for CD36
    mediating antiangiogenic properties. Plays a role in ER stress response, via its interaction with the activating
    transcription factor 6 alpha (ATF6) which produces adaptive ER stress response factors (By similarity)

         Genatlas biochemistry entry for THBS1:
    thrombospondin I (140kDa),glycoprotein expressed in extracellular matrix protein involved in platelet
    aggregation,embryogenesis,morphogenesis,cell adhesion molecule,major activator of TGFB1

         Gene Ontology (GO): Selected molecular function terms (see all 16):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001786phosphatidylserine binding IDA18940719
    GO:0001948glycoprotein binding NAS6438154
    GO:0001968fibronectin binding IDA6693501
    GO:0005178integrin binding IMP17413041
    GO:0005509calcium ion binding NAS9304800
         
    Find genes that share ontologies with THBS1           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for THBS1:
     Decreased TP53 protein express 

         Selected MGI mutant phenotypes (inferred from 1 allele(MGI details for Thbs1) (see all 19):
     cardiovascular system  cellular  digestive/alimentary  endocrine/exocrine gland  growth/size/body 
     hematopoietic system  homeostasis/metabolism  immune system  integument  limbs/digits/tail 
     liver/biliary system  mortality/aging  muscle  renal/urinary system  reproductive system 

    Find genes that share phenotypes with THBS1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Thbs1tm1Hyn for THBS1

       genOway: Develop your customized and physiologically relevant rodent model for THBS1

    miRNA
    Products:
        
    miRTarBase miRNAs that target THBS1:
    hsa-mir-1 (MIRT001328), hsa-let-7b-5p (MIRT001586), hsa-mir-30a-5p (MIRT028645), hsa-let-7d-5p (MIRT032122), hsa-mir-92a-3p (MIRT005628), hsa-let-7a-5p (MIRT004958), hsa-mir-20a-5p (MIRT005627), hsa-mir-30a-3p (MIRT001763), hsa-mir-17-5p (MIRT005626), hsa-mir-155-5p (MIRT020932), hsa-mir-132-3p (MIRT021834), hsa-mir-98-5p (MIRT004943)

    Block miRNA regulation of human, mouse, rat THBS1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate THBS1 (see all 40):
    hsa-let-7d hsa-miR-139-5p hsa-let-7g hsa-let-7a hsa-miR-3148 hsa-miR-2113 hsa-miR-3163 hsa-miR-4264
    SwitchGear 3'UTR luciferase reporter plasmidTHBS1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for THBS1
    Predesigned siRNA for gene silencing in human, mouse, rat THBS1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for THBS1

    Clone
    Products:
         
    OriGene clones in human, mouse for THBS1 (see all 7)
    OriGene ORF clones in mouse, rat for THBS1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: THBS1 (NM_003246)
    Sino Biological Human cDNA Clone for THBS1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for THBS1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat THBS1
    Addgene plasmids for THBS1 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for THBS1
    Browse ESI BIO Cell Lines and PureStem Progenitors for THBS1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for THBS1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    TSP1_HUMAN, P07996: Endoplasmic reticulum (By similarity). Sarcoplasmic reticulum (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    plasma membrane4
    cytoskeleton2
    nucleus2
    cytosol1
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): Selected cellular component terms (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005577fibrinogen complex IDA3997886
    GO:0005615extracellular space IDA--
    GO:0005737cytoplasm ----
    GO:0005783endoplasmic reticulum ISS--

    Find genes that share ontologies with THBS1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for THBS1 About   (see all 26)  
    See pathways by source

    SuperPathContained pathways About
    1Focal adhesion
    Focal adhesion0.65
    ECM-receptor interaction0.31
    Focal Adhesion0.65
    2Response to elevated platelet cytosolic Ca2+
    Response to elevated platelet cytosolic Ca2+0.94
    Platelet degranulation0.94
    3Hemostasis
    Hemostasis0.43
    Platelet activation, signaling and aggregation0.43
    4Non-integrin membrane-ECM interactions
    Non-integrin membrane-ECM interactions0.35
    Syndecan interactions0.00
    5Signaling by FGFR
    Signaling by PDGF0.87


    Find genes that share SuperPaths with THBS1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for THBS1
        Inhibition of Angiogenesis by TSP1
    p53 Signaling

    Selected BioSystems Pathways for THBS1 (see all 6)
        Focal Adhesion
    TGF Beta Signaling Pathway
    Senescence and Autophagy
    Integrated Pancreatic Cancer Pathway
    Syndecan-4-mediated signaling events


    5 Reactome Pathways for THBS1
        Integrin cell surface interactions
    Platelet degranulation
    O-glycosylation of TSR domain-containing proteins
    Signaling by PDGF
    Syndecan interactions


    Selected Kegg Pathways  (Kegg details for THBS1) (see all 11):
        Rap1 signaling pathway
    p53 signaling pathway
    Phagosome
    PI3K-Akt signaling pathway
    TGF-beta signaling pathway

        Pathway & Disease-focused RT2 Profiler PCR Arrays including THBS1 (see all 12): 
              Fibrosis in human mouse rat
              Extracellular Matrix & Adhesion Molecules in human mouse rat
              Angiogenic Growth Factors in human mouse rat
              TGFB/BMP Signaling Pathway in human mouse rat
              Angiogenesis in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for THBS1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for THBS1 (P079961, 2, 3 ENSP000002603564) via UniProtKB, MINT, STRING, and/or I2D (see all 83)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TGFB1P011371, 3, ENSP000002219304EBI-2530274,EBI-779636 I2D: score=3 STRING: ENSP00000221930
    IGFBP5P245933, ENSP000002338134I2D: score=4 STRING: ENSP00000233813
    COL1A1P024523, ENSP000002259644I2D: score=3 STRING: ENSP00000225964
    COL3A1P024613, ENSP000003044084I2D: score=3 STRING: ENSP00000304408
    FN1P027513, ENSP000003468394I2D: score=3 STRING: ENSP00000346839
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 70):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000187activation of MAPK activity IMP17413041
    GO:0001666response to hypoxia NAS9304800
    GO:0001937negative regulation of endothelial cell proliferation IMP17413041
    GO:0001953negative regulation of cell-matrix adhesion IDA17416590
    GO:0002040sprouting angiogenesis IMP17879962

    Find genes that share ontologies with THBS1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for THBS1 (TSP1)

    Selected Novoseek inferred chemical compound relationships for THBS1 gene (see all 103)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    vegf 74.6 341 11856116 (9), 19762163 (7), 12963968 (6), 18788631 (6) (see all 99)
    grgdsp 60.4 7 9362073 (1), 7695484 (1), 7519904 (1), 9351379 (1) (see all 6)
    heparin 51.7 128 1703153 (9), 10222132 (7), 18940719 (6), 14517432 (4) (see all 45)
    grgesp 47 3 9351379 (1), 7737404 (1)
    dauricine 45.4 6 10678148 (2), 11477827 (1)
    tgf beta1 45 22 11955611 (5), 16100902 (4), 15347840 (3), 14583181 (2) (see all 7)
    matrigel 44.3 3 17704650 (1), 9489491 (1), 19158196 (1), 10398144 (1)
    fibrinogen 43.1 81 11094060 (8), 1309961 (3), 7693024 (3), 7947604 (2) (see all 28)
    grgds 42.4 5 1873028 (2), 8305744 (1), 1716458 (1), 7518179 (1)
    procollagen 39.4 8 11016937 (3), 1426766 (2), 11691800 (1), 10391381 (1)



    Find genes that share compounds with THBS1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for THBS1 gene: 
    NM_003246.2  

    Unigene Cluster for THBS1:

    Thrombospondin 1
    Hs.164226  [show with all ESTs]
    Unigene Representative Sequence: NM_003246
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000397591 ENST00000260356(uc001zkh.3 uc010bbi.3) ENST00000478845
    ENST00000497720 ENST00000466755 ENST00000490247 ENST00000560894 ENST00000484734
    ENST00000559746
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat THBS1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate THBS1 (see all 40):
    hsa-let-7d hsa-miR-139-5p hsa-let-7g hsa-let-7a hsa-miR-3148 hsa-miR-2113 hsa-miR-3163 hsa-miR-4264
    SwitchGear 3'UTR luciferase reporter plasmidTHBS1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for THBS1
    Predesigned siRNA for gene silencing in human, mouse, rat THBS1
    Clone
    Products:
         
    OriGene clones in human, mouse for THBS1 (see all 7)
    OriGene ORF clones in mouse, rat for THBS1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: THBS1 (NM_003246)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for THBS1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat THBS1
    Addgene plasmids for THBS1 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for THBS1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat THBS1
      QuantiTect SYBR Green Assays in human, mouse, rat THBS1
      QuantiFast Probe-based Assays in human, mouse, rat THBS1

    Additional mRNA sequence: 

    AB209912.1 AK291639.1 AK293230.1 AK304754.1 AK309613.1 AK310820.1 BC028145.1 BC136469.1 
    BC136470.1 M14326.1 M25631.1 M99425.1 X04665.1 X14787.1 

    Selected DOTS entries (see all 33):

    DT.95317311  DT.100877416  DT.451114  DT.110480  DT.100877417  DT.100823315  DT.70104615  DT.91873884 
    DT.121037763  DT.91765697  DT.121037756  DT.121037716  DT.86836637  DT.100823317  DT.121037762  DT.100751785 
    DT.121637399  DT.40244713  DT.95371378  DT.91765704  DT.92009463  DT.121037724  DT.121037736  DT.121037766 

    Selected AceView cDNA sequences (see all 563):

    AL703097 BP363183 AA343622 AI435944 AI735132 BP356741 BP353916 BQ777478 
    BP352772 AA344177 AI803562 AA164489 AI597702 AW069887 AA373735 BX474156 
    BQ001338 AA056585 BM708062 AL706182 BP364211 BQ014354 AL702954 BU623812 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for THBS1 (see all 6)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18a ·
    SP1:              -                                               -                       -                                         -                           
    SP2:                                                                                                                                                            
    SP3:                                                                                      -                                                                     
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 18b ^ 19a · 19b ^ 20 ^ 21 ^ 22
    SP1:              -                     
    SP2:                                    
    SP3:                                    
    SP4:                                    
    SP5:                                    


    ECgene alternative splicing isoforms for THBS1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    THBS1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGGTCTTCAA
    THBS1 Expression
    About this image


    THBS1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 28) fully expand
     
     Tendon & Ligament (Muscoskeletal System)    fully expand to see all 2 entries
             Tenocytes Limb Tendons and Ligaments
     
     Bone (Muscoskeletal System)    fully expand to see all 3 entries
             Bone Marrow
             Notch-transfected mesenchymal stromal cells (SB623)
     
     Pancreas (Endocrine System)    fully expand to see all 2 entries
             Duct Cells Pancreatic Ducts
             Islets of Langerhans
     
     Fibroblasts
             Cardiac Fibroblasts Myocardium
             Detroit 551
     
     Epithelial Cells
             Duct Cells Pancreatic Ducts
    THBS1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    THBS1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.164226
        Pathway & Disease-focused RT2 Profiler PCR Arrays including THBS1 (see all 12): 
              Fibrosis in human mouse rat
              Extracellular Matrix & Adhesion Molecules in human mouse rat
              Angiogenic Growth Factors in human mouse rat
              TGFB/BMP Signaling Pathway in human mouse rat
              Angiogenesis in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for THBS1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat THBS1
    QuantiTect SYBR Green Assays in human, mouse, rat THBS1
    QuantiFast Probe-based Assays in human, mouse, rat THBS1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for THBS1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for THBS1 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Thbs11 , 5 thrombospondin 11, 5 89.05(n)1
    94.78(a)1
      2 (59.34 cM)5
    218251  NM_011580.31  NP_035710.21 
     1181118765 
    chicken
    (Gallus gallus)
    Aves THBS11 thrombospondin 1 78.8(n)
    85.7(a)
      373987  NM_001199453.1  NP_001186382.1 
    lizard
    (Anolis carolinensis)
    Reptilia THBS16
    thrombospondin 1
    85(a)
    1 ↔ 1
    GL343264.1(1920550-1932401)
    African clawed frog
    (Xenopus laevis)
    Amphibia L04278.12   -- 76.71(n)    L04278.1 
    zebrafish
    (Danio rerio)
    Actinopterygii AI877511.12   -- 75.58(n)   324926  AI877511.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Tsp3 cell adhesion molecule 47(a)     --


    ENSEMBL Gene Tree for THBS1 (if available)
    TreeFam Gene Tree for THBS1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for THBS1 gene
    THBS42  COMP2  THBS32  THBS22  
    5 SIMAP similar genes for THBS1 using alignment to 3 protein entries:     TSP1_HUMAN (see all proteins):
    DKFZp686G02190    THBS3    COMP    THBS4    THBS2

    Find genes that share paralogs with THBS1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for THBS1 (see all 531)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs123248891,2
    C--39871308(+) GTGAGT/CGCTGG 1 -- us2k12Minor allele frequency- C:0.04CSA WA 120
    rs1871849691,2
    --39871518(+) TGGAAA/GGAAGA 1 -- us2k10--------
    rs1121152801,2
    C,F--39871630(+) TGCTTG/CGATGA 1 -- us2k12Minor allele frequency- C:0.04CSA WA 120
    rs1924804901,2
    --39871650(+) TATGAC/TTTGCG 1 -- us2k10--------
    rs720933621,2
    C--39871814(+) GTAAT-/ACAC  
            
    ACACA
    1 -- us2k10--------
    rs1140568451,2
    F--39871902(+) GTAAAC/AACTTG 1 -- us2k11Minor allele frequency- A:0.03WA 118
    rs1423628511,2
    --39871928(+) CGGGAC/GTCCTG 1 -- us2k10--------
    rs614648271,2
    C,F--39872038(+) GGAGCG/CAGCCC 1 -- us2k14Minor allele frequency- C:0.10NA CSA WA 428
    rs21698301,2
    C,F,A,H--39872056(-) CTGTGA/GTCCAG 1 -- us2k122Minor allele frequency- G:0.48NS EA NA WA CSA 2347
    rs1820439111,2
    --39872083(+) GCTGAA/CGTCCC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for THBS1 (39873280 - 39891667 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for THBS1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv1502CNV Loss18451855
    nsv832977CNV Gain17160897
    nsv904094CNV Gain21882294

    Human Gene Mutation Database (HGMD): THBS1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing THBS1
    DNA2.0 Custom Variant and Variant Library Synthesis for THBS1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 188060    OMIM disorders: --

    11 diseases for THBS1:    
    About MalaCards
    hereditary leiomyomatosis and renal cell cancer    gastric cardia adenocarcinoma    thrombotic thrombocytopenic purpura    posterior uveal melanoma
    myxofibrosarcoma    acute chest syndrome    diabetic retinopathy    pilocytic astrocytoma
    astrocytoma    cholangiocarcinoma    malaria

    2 diseases from the University of Copenhagen DISEASES database for THBS1:
    Cancer     Vascular disease

    Find genes that share disorders with THBS1           About GenesLikeMe

    Selected Novoseek inferred disease relationships for THBS1 gene (see all 98)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    purpura thrombotic thrombocytopenic 66.3 8 17367414 (1), 16204318 (1), 16831327 (1), 15890682 (1) (see all 8)
    neovascularization 64 32 19080117 (5), 19024308 (2), 8780385 (1), 12719977 (1) (see all 19)
    tumors 62.5 730 9017002 (10), 10375104 (8), 11712798 (7), 8093068 (6) (see all 99)
    metastasis 51.5 114 17709727 (3), 10427124 (3), 12429967 (3), 7527299 (3) (see all 58)
    cancer 48.3 143 9600434 (4), 10650779 (3), 10427124 (3), 16204059 (3) (see all 76)
    skin carcinoma 47.8 3 9833775 (1), 10051595 (1), 9365532 (1)
    corneal neovascularization 45.1 2 11134179 (1), 12714043 (1)
    ductal breast carcinoma 41.4 3 9012463 (1), 12814189 (1), 7511188 (1)
    melanoma 40.3 70 12447621 (6), 7599038 (4), 9679984 (4), 9618039 (3) (see all 28)
    blood vessel tumors 39.9 1 10595934 (1)

    Genetic Association Database (GAD): THBS1
    Human Genome Epidemiology (HuGE) Navigator: THBS1 (26 documents)

    Export disorders for THBS1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for THBS1 gene, integrated from 10 sources (see all 1175):
    (articles sorted by number of sources associating them with THBS1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The thrombospondin-1 N700S polymorphism is associated with early myocardial infarction without altering von Willebrand factor multimer size. (PubMed id 16684956)1, 4, 9 Zwicker J.I....Mannucci P. (Blood 2006)
    2. Polymorphisms in thrombospondin genes and myocardial infarction: a case-control study and a meta-analysis of available evidence. (PubMed id 18178577)1, 4, 9 Koch W....Kastrati A. (Hum. Mol. Genet. 2008)
    3. TSP1 and MMP9 genetic variants in sporadic prostate cancer. (PubMed id 17175378)1, 4, 9 Sfar S....Chouchane L. (Cancer Genet. Cytogenet. 2007)
    4. Genetic association analysis of myocardial infarction with thrombospondin-1 N700S variant in a Chinese population. (PubMed id 15140581)1, 4, 9 Zhou X....Gu D. (Thromb. Res. 2004)
    5. [Correlation of thrombospondin-1 G1678A polymorphism to stroke: a study in Chinese population]. (PubMed id 15730804)1, 4, 9 Liu X.N....Hui R.T. (Zhonghua Yi Xue Za Zhi 2004)
    6. Biophysical characterization, including disulfide bond assignments, of the anti-angiogenic type 1 domains of human thrombospondin-1. (PubMed id 12450399)1, 2, 9 Huwiler K.G.... Mosher D.F. (Biochemistry 2002)
    7. Crystal structure of the TSP-1 type 1 repeats: a novel layered fold and its biological implication. (PubMed id 12391027)1, 2, 9 Tan K.... Wang J.-H. (J. Cell Biol. 2002)
    8. Histidine-rich glycoprotein inhibits the antiangiogenic effect of thrombospondin-1. (PubMed id 11134179)1, 2, 9 Simantov R....Silverstein R.L. (J. Clin. Invest. 2001)
    9. Structure and chromosomal localization of the human thrombospondin gene. (PubMed id 2341158)1, 3, 9 Wolf F.W....Dixit V.M. (Genomics 1990)
    10. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 7057 HGNC: 11785 AceView: THBS1 Ensembl:ENSG00000137801 euGenes: HUgn7057
    ECgene: THBS1 Kegg: 7057 H-InvDB: THBS1

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for THBS1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for THBS1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for THBS1 gene:
    Search GeneIP for patents involving THBS1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Antibodies for THBS1 (Thrombospondin-1)   Browse Cell Culture Products  
     ELISAs for THBS1 (Thrombospondin-1)   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Recombinant/Natural Proteins for THBS1 (Thrombospondin-1)   Browse Stem Cell Products  
     Browse cDNA Clones   Proteome Profiler Antibody Arrays for THBS1 (Thrombospondin-1)  
     OriGene Antibodies for THBS1   OriGene RNAi products in human, mouse, rat for THBS1  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for THBS1  
     OriGene MassSpec for THBS1   OriGene clones in human, mouse for THBS1  
     OriGene qSTAR qPCR primer pairs in human, mouse for THBS1   OriGene Purified Protein for THBS1  
     OriGene ORF clones in mouse, rat for THBS1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for THBS1   OriGene Custom Protein Services for THBS1  

     
     
     Block miRNA regulation of human, mouse, rat THBS1 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing THBS1
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat THBS1 Predesigned siRNA for gene silencing in human, mouse, rat THBS1
     QuantiFast Probe-based Assays in human, mouse, rat THBS1 QuantiTect SYBR Green Assays in human, mouse, rat THBS1
     PCR Arrays including human, mouse, rat THBS1 Search Chromatin IP Primers for THBS1
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat THBS1  GeneGlobe Interaction Network for THBS1
     Regulatory tfbs in THBS1 promoter
     GenScript Custom Purified and Recombinant Proteins Services for THBS1 GenScript cDNA clones with any tag delivered in your preferred vector for THBS1
     GenScript Custom Assay Services for THBS1 GenScript Custom overexpressing Cell Line Services for THBS1
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for THBS1 (TSP1)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for THBS1
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     THBS1 antibodies
     THBS1 proteins
     THBS1 lysates
     Antibodies for THBS1
     See all of Abcam's Antibodies, Kits and Proteins for THBS1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for THBS1
     Proteins for THBS1
     Antibodies for THBS1
     ELISAs for THBS1
     CLIAs for THBS1



     Browse ESI BIO Cell Lines and PureStem Progenitors for THBS1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for THBS1
     SwitchGear 3'UTR luciferase reporter plasmids for THBS1
     SwitchGear Promoter luciferase reporter plasmids for THBS1
     ThermoFisher Antibody for THBS1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat THBS1
     Browse compounds at ApexBio
     Addgene plasmids for THBS1
      Search eBioscience for proteins for THBS1
      Search eBioscience for elisas for THBS1
      eBioscience FlowRNA Probe Sets
     genOway: Develop your customized and physiologically relevant rodent model for THBS1
     antibodies-online antibodies for THBS1 (121 products)
     antibodies-online kits for THBS1 (29 products)
     antibodies-online peptides for THBS1
     antibodies-online proteins for THBS1 (19 products)
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      THBS1 gene at Home site.
    Version: 3.12.252 27 Nov 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4