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THBS1 Gene

protein-coding GIFtS: 69

GC15P037660

thrombospondin 1
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
THBS ^¹, ²
THBS-1 ^¹, ²
TSP ^¹, ², ³
TSP-1 ^¹, ²
TSP1 ^¹, ², ³
thrombospondin-1p180 ^²

Descriptions
thrombospondin 1 ^²

External Ids
HGNC: 11785¹
Entrez Gene: 7057²
UniProtKB: P07996³
Ensembl: ENSG00000137801⁷

Search outside databases for aliases for THBS1 gene

Previous GC identifers: GC15P035240 GC15P032769 GC15P037452 GC15P037589

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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EntrezGene summary for THBS1:

The protein encoded by this gene is a subunit of a disulfide-linked homotrimeric protein. This

protein is an adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions.

This protein can bind to fibrinogen, fibronectin, laminin, type V collagen and integrins

alpha-V/beta-1. This protein has been shown to play roles in platelet aggregation, angiogenesis,

and tumorigenesis. [provided by RefSeq]

UniProtKB/Swiss-Prot: TSP1_HUMAN, P07996

Function: Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Can

bind to fibrinogen, fibronectin, laminin, type V collagen and integrins alpha-V/beta-1,

alpha-V/beta-3 and alpha-IIb/beta-3

Gene Wiki entry for THBS1 (Thrombospondin_1)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the THBS1 gene

Entrez Gene cytogenetic band: 15q15 Ensembl cytogenetic band: 15q14 HGNC cytogenetic band: 15q15

THBS1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 15 GeneLoc Exon Structure

GeneLoc location for GC15P037660: (about GC identifiers)

Start:	37,660,572 bp from pter
End:	37,681,845 bp from pter
Size:	21,274 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000015.8 NT_010194.16

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: TSP1_HUMAN, P07996 (See protein sequence)

Recommended Name: Thrombospondin-1 precursor

Size: 1170 amino acids; 129383 Da

Subunit: Homotrimer; disulfide-linked

PDB structures from and Proteopedia :

1LSL (3D)

1UX6 (3D)

1Z78 (3D)

1ZA4 (3D)

2ERF (3D)

2ES3 (3D)

2OUH (3D)

2OUJ (3D)

Secondary accessions: Q15667

REFSEQ proteins: NP_003237.2

ENSEMBL proteins:

ENSP00000380720 ENSP00000260356 ENSP00000380721

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	R&D Systems Recombinant & Natural Proteins for THBS1 (Thrombospondin-1)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Thrombospondin)
	Browse Abnova for Human Recombinant Proteins

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

5 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	IEA	--
GO:0005577	fibrinogen complex	IDA	3997886
GO:0009897	external side of plasma membrane	IDA	6777381
GO:0031012	extracellular matrix	TAS	9304800
GO:0031093	platelet alpha granule lumen	EXP	6338048

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Antibodies for THBS1:

	Invitrogen Antibodies for THBS1
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for THBS1
	R&D Systems Antibodies for THBS1 (Thrombospondin-1)
	Antibodies from Abcam (Thrombospondin), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (THBS1)
	Novus Biologicals Antibody for THBS1

Assays for THBS1:

	Browse Invitrogen for biochemical assays
	Millipore Kits and Assays for the Analysis of THBS1
	R&D Systems ELISAs for THBS1 (Thrombospondin-1) (see all)
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P07996

ProtoNet protein and cluster: P07996

5/7 Blocks protein families (see all 7 ):

IPB000884 Thrombospondin

IPB001007 von Willebrand factor

IPB001881 EGF-like calcium-binding

IPB003129 Thrombospondin

IPB006210 Type I EGF

UniProtKB/Swiss-Prot: TSP1_HUMAN, P07996

Similarity: Belongs to the thrombospondin family

Similarity: Contains 3 EGF-like domains

Similarity: Contains 1 TSP C-terminal (TSPC) domain

Similarity: Contains 1 TSP N-terminal (TSPN) domain

Similarity: Contains 3 TSP type-1 domains

Similarity: Contains 8 TSP type-3 repeats

Similarity: Contains 1 VWFC domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (THBS1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (THBS1)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_003246

Applied Biosystems Silencer® siRNAs for THBS1

Sigma-Aldrich siRNA for THBS1

Sigma-Aldrich shRNA Panels and shRNA for THBS1

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_003246
Myc/DDK tagged cDNA clone in CMV expression vector: NM_003246
untagged cDNA clone in CMV expression vector: NM_003246

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_003246

UniProtKB/Swiss-Prot: TSP1_HUMAN, P07996

Function: Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Can

bind to fibrinogen, fibronectin, laminin, type V collagen and integrins alpha-V/beta-1,

alpha-V/beta-3 and alpha-IIb/beta-3

Genatlas biochemistry entry for THBS1:

thrombospondin I (140kDa),glycoprotein expressed in extracellular matrix protein involved in

platelet aggregation,embryogenesis,morphogenesis,cell adhesion molecule,major activator of TGFB1

15/18 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Thbs1) (see all 18 ):

	digestive/alimentary	endocrine/exocrine gland	growth/size	hematopoietic system
homeostasis/metabolism	immune system	lethality-prenatal/perinatal	life span-post-weaning/aging	limbs/digits/tail
liver/biliary system	muscle	renal/urinary system	reproductive system	respiratory system

5/14 Gene Ontology (GO) molecular function terms (links to tree view) (see all 14 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001968	fibronectin binding	IPI	6693501
GO:0005178	integrin binding	IMP	17413041 18757424
GO:0005198	structural molecule activity	IEA	--
GO:0005509	calcium ion binding	IEA	--
GO:0008201	heparin binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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2 Sigma-Aldrich "Your Favorite Gene" Pathways for THBS1 (Your Favorite Gene powered by Ingenuity)

Bladder Cancer Signaling
p53 Signaling

GeneDecks THBS1 for the pathways selected above

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Gene Network Central^TM Interacting Genes and Proteins Network for THBS1

5/152 Interacting proteins for THBS1 (P07996² ENSP00000260356³) via UniProtKB, MINT, and/or STRING (see all 152 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CD47	ENSP00000355361³	STRING (score=.999)
FN1	ENSP00000323534³	STRING (score=.998)
MMP9	ENSP00000361405³	STRING (score=.995)
PDGFB	ENSP00000330382³	STRING (score=.988)
TGFB1	ENSP00000221930³	STRING (score=.988)

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5/40 Gene Ontology (GO) biological process terms (links to tree view) (see all 40 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000187	activation of MAPK activity	IMP	17413041
GO:0001666	response to hypoxia	NAS	9304800
GO:0001937	negative regulation of endothelial cell proliferation	IMP	17413041
GO:0002040	sprouting angiogenesis	IMP	17879962
GO:0002544	chronic inflammatory response	IEP	18674744

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for THBS1
10/51 Novoseek chemical compound relationships for THBS1 gene (see all 51 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
grgdsp	61.55	7	9362073 (1), 7695484 (1), 7519904 (1), 9351379 (1) (see all 6)
grgesp	48.01	3	9351379 (1), 7737404 (1)
tgf beta1	44.58	22	11955611 (5), 16100902 (4), 15347840 (3), 14583181 (2) (see all 7)
fibrinogen	44.21	81	11094060 (8), 1309961 (3), 7693024 (3), 7947604 (2) (see all 28)
matrigel	43.63	3	17704650 (1), 9489491 (1), 19158196 (1), 10398144 (1)
procollagen	38.29	8	11016937 (3), 1426766 (2), 11691800 (1), 10391381 (1)
lm 609	36.97	1	1384794 (1)
heparan sulfate	24.62	23	14517432 (3), 9989246 (2), 9328841 (1), 15868907 (1) (see all 6)
sulfatide	22.55	2	18226512 (1), 8375932 (1)
aminosugars	22.35	2	9127003 (1)

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(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (THBS1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (THBS1)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_003246

Sigma-Aldrich siRNA for THBS1

Sigma-Aldrich shRNA Panels and shRNA for THBS1

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_003246

REFSEQ mRNAs for THBS1 gene:

NM_003246.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_003246

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_003246
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_003246
                                 untagged cDNA clone in CMV expression vector: NM_003246

Additional cDNA sequence:

AB209912.1 AK291639.1 AK293230.1 AK304754.1 AK309613.1 AK310820.1 BC015134.1 BC028145.1

BC136469.1 BC136470.1 M14326.1 M25631.1 M99425.1 X04665.1 X14787.1

24/33 DOTS entries (see all 33 ):

DT.95317311 DT.451114 DT.100877416 DT.110480 DT.100877417 DT.100823315 DT.70104615 DT.121037763

DT.91873884 DT.91765697 DT.86836637 DT.92050749 DT.121037716 DT.121037756 DT.121037762 DT.100823317

DT.40244713 DT.92009463 DT.95371378 DT.91765704 DT.97803063 DT.121037724 DT.121037736 DT.121037766

24/563 AceView cDNA sequences (see all 563 ):

BX951694 X04665 BQ001338 AW997017 AL703372 AA232790 BX501555 CA411820

BQ019617 BF001661 AA373735 AL706182 CA952741 AI750877 AW629780 BP363450

BX504657 N39897 NM_003246 BG251073 CN482761 BI907705 AV660617 AV656566

highest scoring ESTs for THBS1:

X14787 AA007557 AA027235 AA037609 AA056491 AA080998 AA080999 AA081394 AA225986 AA308199

Unigene Cluster for THBS1:

Thrombospondin 1

Hs.164226 [show with all ESTs]

Unigene Representative Sequence: NM_003246

GeneLoc Exon Structure

5/6 Alternative Splicing Database (ASD) splice patterns (SP) for THBS1 (see all 6 )

ExUns:	1a	·	1b	^	2a	·	2b	^	3a	·	3b	^	4	^	5	^	6	^	7	^	8a	·	8b	·	8c	^	9a	·	9b	^	10a	·	10b	^	11	^	12	^	13	^	14	^	15a	·	15b	^	16	^	17	^	18a	·
SP1:					-																-								-														-
SP2:
SP3:																													-
SP4:
SP5:

ExUns:	18b	^	19a	·	19b	^	20	^	21	^	22
SP1:					-
SP2:
SP3:
SP4:
SP5:

About this scheme

ECgene alternative splicing isoforms for THBS1

3 Ensembl transcripts including schematic representations:

ENST00000397591 ENST00000260356 ENST00000397593

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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THBS1 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for THBS1

¹ / ² / ³

11 probe-sets matching THBS1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
867_s_at²^{, 3}	U95-A	1	1.00	1.00	0.80	1.02	U12471	0.20	1.00	0.72	1
115_at²^{, 3}	U95-A	1	1.00	1.00	0.95	0.92	X14787	1.00	1.00	1.00	1
866_at*²^{, 3}	U95-A	1	--	--	0.20	1.10	U12471	0.20	1.00	0.72	1
201107_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AI812030	0.40	1.00	0.76	1
201110_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_003246	0.60	1.00	0.82	1
201109_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AV726673	0.60	1.00	0.82	1
201108_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	BF055462	0.80	1.00	0.91	1
201107_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
201110_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
201109_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
201108_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks THBS1 for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: AGGTCTTCAA

SOURCE GeneReport for Unigene cluster: Hs.164226
Expression variation in blood from EXPOLDB for THBS1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
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Orthologs for THBS1 gene from 5/9 species (see all 9 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	THBS1¹	--	thrombospondin 1	91.3(n) 97.26(a)	487486 XM_544610.2 XP_544610.2
chimpanzee (Pan troglodytes)	THBS1¹	--	thrombospondin 1	99.69(n) 99.74(a)	453319 XM_510294.2 XP_510294.2
cow (Bos taurus)	THBS1¹	--	thrombospondin 1	92.13(n) 96.75(a)	281530 NM_174196.1 NP_776621.1
mouse (Mus musculus)	Thbs1^{1, 5}	2 (65.00 cM)⁵	thrombospondin 1^{1, 5}	89.05(n)¹ 94.78(a)¹	21825¹ NM_011580.3¹ NP_035710.2¹ AI385532⁵ AK080686⁵ (see all 39)
chicken (Gallus gallus)	THBS1¹	--	thrombospondin 1	78.9(n) 85.96(a)	373987 XM_421205.2 XP_421205.2

About this table Species with no ortholog for THBS1

ENSEMBL Gene Tree for THBS1

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
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Paralogs for THBS1 gene

THBS2²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/126 NCBI SNPs in THBS1 are shown (see all 126 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 74)

AB	SNP ID	Valid	Chr 15 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs1478604^1,2	A,C,F,H,O	37660613(-)	`GAGCGA/GCAGGA`	1	--	ut5¹		10		MN EU EA WA NA	1030
	rs1051442^1,2	C,F,H,O	37674941(+)	`GAAAAC/TCCCCA`	1	--	ut3¹ ese³		19		MN NA EU EA WA	1722
--	rs2292305^1,2	A,C,F,H	37668114(-)	`GGGTGT/CGGGGT`	1	A/T	mis¹ ese³		15		EA EU WA NA	2068
	rs2228262^1,2	C,F,H,O	37669470(+)	`GCCCAA/GTGAGA`	1	N/S	mis¹ ese³		14		MN NA EU EA WA	1172
	rs3743125^1,2	A,C,F,H	37675140(-)	`CTTCCC/TAACTG`	1	--	ut3¹		14		EA NA EU WA	2124
	rs1478605^1,2	A,C,F,H	37660576(-)	`CGCAGC/TGGCTG`	1	--	ut5¹ ese³		7		MN EU EA WA NA	610
	rs17633107^1,2	C,F,H	37675573(+)	`AGGGAA/CTCAGA`	1	--	ut3¹		9		NA EU EA WA	652
	rs7163020^1,2	C,F,H	37675360(+)	`GAAGAA/TAATAT`	1	--	ut3¹		5		EU EA WA NA	460
	rs2169830^1,2	A,C	37659348(-)	`CTGTGA/GTCCAG`	1	--	ng5¹		0	--	--	--	--
--	rs2664139^1,2	C,F	37659875(+)	`AGGCGT/CCTCTG`	1	--	ng5¹		2		MN EA	356

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HapMap Linkage Disequilibrium images for THBS1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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OMIM: 188060

10/97 Novoseek disease relationships for THBS1 gene (see all 97 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
purpura thrombotic thrombocytopenic	65.94	8	17367414 (1), 16204318 (1), 16831327 (1), 15890682 (1) (see all 8)
neovascularization	65.56	32	19080117 (5), 19024308 (2), 8780385 (1), 12719977 (1) (see all 19)
tumors	61.43	666	9017002 (10), 10375104 (8), 11712798 (7), 8093068 (6) (see all 99)
metastasis	50.27	105	17709727 (3), 10427124 (3), 12429967 (3), 7527299 (3) (see all 53)
skin carcinoma	49.72	3	9833775 (1), 10051595 (1), 9365532 (1)
cancer	46.11	130	9600434 (4), 10650779 (3), 10427124 (3), 16204059 (3) (see all 67)
blood vessel tumors	42.51	1	10595934 (1)
cancer invasiveness	40.46	2	16732887 (1)
melanoma	39.40	70	12447621 (6), 7599038 (4), 9679984 (4), 9618039 (3) (see all 28)
breast carcinoma	38.73	28	10196234 (3), 7527299 (3), 9012463 (2), 15838828 (2) (see all 15)

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Human Gene Mutation Database: THBS1
Genetic Association Database: THBS1
Human Genome Epidemiology Navigator: THBS1 (13 documents)

(Possibly Related Articles in Doctor's Guide)
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(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/944 PubMed articles for THBS1 gene (see all 944 ):

Genetic association analysis of myocardial infarction with thrombospondin-1 N700S variant in a Chinese population. (PubMed id 15140581)^{1, 3, 6} Zhou X....Gu D. (2004)
[Correlation of thrombospondin-1 G1678A polymorphism to stroke: a study in Chinese population] (PubMed id 15730804)^{1, 3, 6} Liu X.N....Hui R.T. (2004)
Biophysical characterization, including disulfide bond assignments, of the anti-angiogenic type 1 domains of human thrombospondin-1. (PubMed id 12450399)^{1, 3, 4} Huwiler K.G.... Mosher D.F. (2002)
Structure and chromosomal localization of the human thrombospondin gene. (PubMed id 2341158)^{1, 2, 3} Wolf F.W....Dixit V.M. (1990)
Elucidation of N-glycosylation sites on human platelet proteins: a glycoproteomic approach. (PubMed id 16263699)^{3, 4} Lewandrowski U.... Sickmann A. (2006)
Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry. (PubMed id 16740002)^{3, 4} Ramachandran P....Loo J.A. (2006)
Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PubMed id 16335952)^{3, 4} Liu T.... Smith R.D. (2005)
Evidence for substantial effect modification by gender in a large-scale genetic association study of the metabolic syndrome among coronary heart disease patients. (PubMed id 14557872)^{3, 6} McCarthy J.J....Topol E.J. (2003)
Thrombospondin-2 polymorphism is associated with a reduced risk of premature myocardial infarction. (PubMed id 12482844)^{3, 6} Boekholdt S.M....Reitsma P.H. (2002)
C-mannosylation and O-fucosylation of the thrombospondin type 1 module. (PubMed id 11067851)^{3, 4} Hofsteenge J.... Peter-Katalinic J. (2001)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 7057	HGNC: 11785	AceView: THBS1	Ensembl:ENSG00000137801	euGenes: HUgn7057
ECgene: THBS1	H-InvDB: THBS1

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for THBS1	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for THBS1
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for THBS1:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for THBS1-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for THBS1		Antibodies for THBS1
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for THBS1		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Search for Recombinant Proteins
	Antibodies (THBS1)
	Chimera RNAi (THBS1)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (Thrombospondin)
	Antibodies (Thrombospondin)

Search OriGene for THBS1

Search Tocris compounds for THBS1

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for THBS1

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

about GIFtS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
THBS1 Gene at Home site.
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THBS1 Gene

protein-coding GIFtS: 69

Aliases &
Descriptions
for THBS1

Summaries
for THBS1

Genomic Location
for THBS1

Proteins
for THBS1

Protein Domains/
Families
for THBS1

Gene Function
for THBS1

Pathways & Interactions
for THBS1

Drugs & Compounds
for THBS1

Transcripts
for THBS1

Expression
for THBS1

Orthologs
for THBS1

Paralogs
for THBS1

SNPs/Variants
for THBS1

Disorders & Mutations
for THBS1

Medical News
for THBS1

Publications
for THBS1

Search for THBS1

Genome Databases showing THBS1

Other Databases showing THBS1

Specialized Databases showing THBS1

Licensable Technologies
for THBS1

Services
for THBS1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

THBS1 Gene

protein-coding GIFtS: 69

Aliases & Descriptionsfor THBS1

Summariesfor THBS1

Genomic Locationfor THBS1

Proteinsfor THBS1

Protein Domains/Familiesfor THBS1

Gene Functionfor THBS1

Pathways & Interactionsfor THBS1

Drugs & Compoundsfor THBS1

Transcriptsfor THBS1

Expression for THBS1

Orthologsfor THBS1

Paralogsfor THBS1

SNPs/Variantsfor THBS1

Disorders & Mutationsfor THBS1

Medical Newsfor THBS1

Publicationsfor THBS1

Search for THBS1

Genome Databases showing THBS1

Other Databases showing THBS1

Specialized Databases showing THBS1

Licensable Technologiesfor THBS1

Servicesfor THBS1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for THBS1

Summaries
for THBS1

Genomic Location
for THBS1

Proteins
for THBS1

Protein Domains/
Families
for THBS1

Gene Function
for THBS1

Pathways & Interactions
for THBS1

Drugs & Compounds
for THBS1

Transcripts
for THBS1

Expression
for THBS1

Orthologs
for THBS1

Paralogs
for THBS1

SNPs/Variants
for THBS1

Disorders & Mutations
for THBS1

Medical News
for THBS1

Publications
for THBS1

Licensable Technologies
for THBS1

Services
for THBS1