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Aliases for THBS1 Gene

Aliases for THBS1 Gene

  • Thrombospondin 1 2 3 5
  • Thrombospondin-1p180 2 3
  • TSP1 3 4
  • TSP 3 4
  • Thrombospondin-P50 3
  • THBS-1 3
  • TSP-1 3
  • THBS 3

External Ids for THBS1 Gene

Previous GeneCards Identifiers for THBS1 Gene

  • GC15P035240
  • GC15P032769
  • GC15P037452
  • GC15P037589
  • GC15P037660
  • GC15P039873
  • GC15P016716

Summaries for THBS1 Gene

Entrez Gene Summary for THBS1 Gene

  • The protein encoded by this gene is a subunit of a disulfide-linked homotrimeric protein. This protein is an adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. This protein can bind to fibrinogen, fibronectin, laminin, type V collagen and integrins alpha-V/beta-1. This protein has been shown to play roles in platelet aggregation, angiogenesis, and tumorigenesis. [provided by RefSeq, Jul 2008]

GeneCards Summary for THBS1 Gene

THBS1 (Thrombospondin 1) is a Protein Coding gene. Diseases associated with THBS1 include posterior uveal melanoma and thrombotic thrombocytopenic purpura, acquired. Among its related pathways are Bladder cancer and ECM-receptor interaction. GO annotations related to this gene include calcium ion binding and heparin binding. An important paralog of this gene is THBS4.

UniProtKB/Swiss-Prot for THBS1 Gene

  • Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Binds heparin. May play a role in dentinogenesis and/or maintenance of dentin and dental pulp (By similarity). Ligand for CD36 mediating antiangiogenic properties. Plays a role in ER stress response, via its interaction with the activating transcription factor 6 alpha (ATF6) which produces adaptive ER stress response factors (By similarity).

Gene Wiki entry for THBS1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for THBS1 Gene

Genomics for THBS1 Gene

Regulatory Elements for THBS1 Gene

Enhancers for THBS1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around THBS1 on UCSC Golden Path with GeneCards custom track

Promoters for THBS1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around THBS1 on UCSC Golden Path with GeneCards custom track

Genomic Location for THBS1 Gene

Chromosome:
15
Start:
39,581,079 bp from pter
End:
39,599,466 bp from pter
Size:
18,388 bases
Orientation:
Plus strand

Genomic View for THBS1 Gene

Genes around THBS1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
THBS1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for THBS1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for THBS1 Gene

Proteins for THBS1 Gene

  • Protein details for THBS1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P07996-TSP1_HUMAN
    Recommended name:
    Thrombospondin-1
    Protein Accession:
    P07996
    Secondary Accessions:
    • A8K6H4
    • B4E3J7
    • B9EGH6
    • Q15667
    • Q59E99

    Protein attributes for THBS1 Gene

    Size:
    1170 amino acids
    Molecular mass:
    129383 Da
    Quaternary structure:
    • Homotrimer; disulfide-linked. Interacts (via the TSP type I repeats) with HRG; the interaction blocks the antiangiogenic effect of THBS1 with CD36 (By similarity). Can bind to fibrinogen, fibronectin, laminin, type V collagen and integrins alpha-V/beta-1, alpha-V/beta-3 and alpha-IIb/beta-3. Interacts (via the TSP type I repeats) with CD36; the interaction conveys an antiangiogenic effect. Interacts with ATF6 (via lumenal domain) (By similarity).
    SequenceCaution:
    • Sequence=BAD93149.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for THBS1 Gene

    Alternative splice isoforms for THBS1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for THBS1 Gene

Proteomics data for THBS1 Gene at MOPED

Post-translational modifications for THBS1 Gene

  • Glycosylation at Asn 248, Thr 292, Thr 302, Asn 360, Trp 385, Ser 394, Trp 438, Trp 441, Thr 450, Trp 498, Thr 507, Thr 638, Asn 708, and Asn 1067
  • Modification sites at PhosphoSitePlus

Other Protein References for THBS1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for THBS1 (Thrombospondin-1)
  • Cell Signaling Technology (CST) Antibodies for THBS1 (THBS1)

No data available for DME Specific Peptides for THBS1 Gene

Domains & Families for THBS1 Gene

Suggested Antigen Peptide Sequences for THBS1 Gene

Graphical View of Domain Structure for InterPro Entry

P07996

UniProtKB/Swiss-Prot:

TSP1_HUMAN :
  • Contains 2 EGF-like domains.
  • Belongs to the thrombospondin family.
  • Contains 8 TSP type-3 repeats.
Domain:
  • Contains 2 EGF-like domains.
  • Contains 1 laminin G-like domain.
  • Contains 1 TSP C-terminal (TSPC) domain.
  • Contains 3 TSP type-1 domains.
  • Contains 1 VWFC domain.
Family:
  • Belongs to the thrombospondin family.
Similarity:
  • Contains 8 TSP type-3 repeats.
genes like me logo Genes that share domains with THBS1: view

No data available for Gene Families for THBS1 Gene

Function for THBS1 Gene

Molecular function for THBS1 Gene

GENATLAS Biochemistry:
thrombospondin I (140kDa),glycoprotein expressed in extracellular matrix protein involved in platelet aggregation,embryogenesis,morphogenesis,cell adhesion molecule,major activator of TGFB1
UniProtKB/Swiss-Prot Function:
Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Binds heparin. May play a role in dentinogenesis and/or maintenance of dentin and dental pulp (By similarity). Ligand for CD36 mediating antiangiogenic properties. Plays a role in ER stress response, via its interaction with the activating transcription factor 6 alpha (ATF6) which produces adaptive ER stress response factors (By similarity).

Gene Ontology (GO) - Molecular Function for THBS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005178 integrin binding IMP 17413041
genes like me logo Genes that share ontologies with THBS1: view
genes like me logo Genes that share phenotypes with THBS1: view

Animal Models for THBS1 Gene

MGI Knock Outs for THBS1:

Animal Model Products

miRNA for THBS1 Gene

miRTarBase miRNAs that target THBS1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for THBS1 Gene

Localization for THBS1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for THBS1 Gene

Endoplasmic reticulum. Sarcoplasmic reticulum.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for THBS1 Gene COMPARTMENTS Subcellular localization image for THBS1 gene
Compartment Confidence
extracellular 5
plasma membrane 5
endoplasmic reticulum 4
cytoskeleton 2
cytosol 2
nucleus 2
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for THBS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum ISS --
GO:0031093 platelet alpha granule lumen TAS --
genes like me logo Genes that share ontologies with THBS1: view

Pathways & Interactions for THBS1 Gene

genes like me logo Genes that share pathways with THBS1: view

Pathways by source for THBS1 Gene

SIGNOR curated interactions for THBS1 Gene

Activates:

Gene Ontology (GO) - Biological Process for THBS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000187 activation of MAPK activity IMP 17413041
GO:0001666 response to hypoxia NAS 9304800
GO:0001937 negative regulation of endothelial cell proliferation IMP 17413041
GO:0002544 chronic inflammatory response IEP 18674744
GO:0002605 negative regulation of dendritic cell antigen processing and presentation IDA 16882710
genes like me logo Genes that share ontologies with THBS1: view

Drugs & Compounds for THBS1 Gene

(49) Drugs for THBS1 Gene - From: DGIdb and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
CVX-045 Pharma Antibody Others 0

(55) Additional Compounds for THBS1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with THBS1: view

Transcripts for THBS1 Gene

Unigene Clusters for THBS1 Gene

Thrombospondin 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for THBS1 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18a ·
SP1: - - - -
SP2:
SP3: -
SP4:
SP5:
SP6:

ExUns: 18b ^ 19a · 19b ^ 20 ^ 21 ^ 22
SP1: -
SP2:
SP3:
SP4:
SP5:
SP6:

Relevant External Links for THBS1 Gene

GeneLoc Exon Structure for
THBS1
ECgene alternative splicing isoforms for
THBS1

Expression for THBS1 Gene

mRNA expression in normal human tissues for THBS1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for THBS1 Gene

This gene is overexpressed in Platelet (25.4), Bone marrow mesenchymal stem cell (18.2), Amniocyte (9.7), and Peripheral blood mononuclear cells (7.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for THBS1 Gene



SOURCE GeneReport for Unigene cluster for THBS1 Gene Hs.164226

genes like me logo Genes that share expression patterns with THBS1: view

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for THBS1 Gene

Orthologs for THBS1 Gene

This gene was present in the common ancestor of animals.

Orthologs for THBS1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia THBS1 35
  • 92.13 (n)
  • 96.75 (a)
THBS1 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia THBS1 35
  • 91.3 (n)
  • 97.26 (a)
THBS1 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Thbs1 35
  • 89.05 (n)
  • 94.78 (a)
Thbs1 16
Thbs1 36
  • 95 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia THBS1 35
  • 99.69 (n)
  • 99.74 (a)
THBS1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Thbs1 35
  • 88.99 (n)
  • 95.3 (a)
oppossum
(Monodelphis domestica)
Mammalia THBS1 36
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia THBS1 36
  • 87 (a)
OneToOne
chicken
(Gallus gallus)
Aves THBS1 35
  • 78.8 (n)
  • 85.7 (a)
THBS1 36
  • 85 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia THBS1 36
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia thbs1 35
  • 75.06 (n)
  • 81.93 (a)
zebrafish
(Danio rerio)
Actinopterygii -- 35
thbs1 35
  • 71.94 (n)
  • 75.77 (a)
THBS1 (2 of 2) 36
  • 80 (a)
OneToMany
thbs1b 36
  • 75 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Tsp 37
  • 47 (a)
Tsp 36
  • 36 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 51 (a)
OneToMany
Species with no ortholog for THBS1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for THBS1 Gene

ENSEMBL:
Gene Tree for THBS1 (if available)
TreeFam:
Gene Tree for THBS1 (if available)

Paralogs for THBS1 Gene

(5) SIMAP similar genes for THBS1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with THBS1: view

Variants for THBS1 Gene

Sequence variations from dbSNP and Humsavar for THBS1 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs2292305 - 39,588,621(-) GGGTG(C/G/T)GGGGT intron-variant, nc-transcript-variant, reference, missense
rs2228262 - 39,589,977(+) GCCCA(A/G)TGAGA nc-transcript-variant, reference, missense
rs41515347 - 39,582,195(+) CAGAG(G/T)CTGGC nc-transcript-variant, reference, missense
rs9719 -- 39,598,734(+) AGTTT(A/T)TTGTC utr-variant-3-prime
rs11282 -- 39,597,349(+) TAGGA(A/G)TGTGC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for THBS1 Gene

Variant ID Type Subtype PubMed ID
nsv904094 CNV Gain 21882294
nsv832977 CNV Gain 17160897
nsv1502 CNV Loss 18451855

Variation tolerance for THBS1 Gene

Residual Variation Intolerance Score: 23.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.94; 89.85% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for THBS1 Gene

HapMap Linkage Disequilibrium report
THBS1
Human Gene Mutation Database (HGMD)
THBS1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for THBS1 Gene

Disorders for THBS1 Gene

MalaCards: The human disease database

(21) MalaCards diseases for THBS1 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
posterior uveal melanoma
  • medium/large size posterior uveal melanoma
thrombotic thrombocytopenic purpura, acquired
  • idiopathic thrombotic thrombocytopenic purpura
myositis
  • inflammatory disorder of muscle
gastric cardia adenocarcinoma
  • adenocarcinoma of cardia of stomach
corneal neovascularization
- elite association - COSMIC cancer census association via MalaCards
Search THBS1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for THBS1

Genetic Association Database (GAD)
THBS1
Human Genome Epidemiology (HuGE) Navigator
THBS1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
THBS1
genes like me logo Genes that share disorders with THBS1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for THBS1 Gene

Publications for THBS1 Gene

  1. The thrombospondin-1 N700S polymorphism is associated with early myocardial infarction without altering von Willebrand factor multimer size. (PMID: 16684956) Zwicker J.I. … Mannucci P. (Blood 2006) 3 48 67
  2. Aberrant methylation of thrombospondin-1 and its association with reduced expression in gastric cardia adenocarcinoma. (PMID: 20300551) Guo W. … Kuang G. (J. Biomed. Biotechnol. 2010) 3 23
  3. Differential changes in platelet VEGF, Tsp, CXCL12, and CXCL4 in patients with metastatic cancer. (PMID: 20182908) Wiesner T. … Kopp H.G. (Clin. Exp. Metastasis 2010) 3 23
  4. The role of thymidine phosphorylase in the induction of early growth response protein-1 and thrombospondin-1 by 5-fluorouracil in human cancer carcinoma cells. (PMID: 20372793) Matsushita S. … Akiyama S. (Int. J. Oncol. 2010) 3 23
  5. Overexpression of RRM2 decreases thrombspondin-1 and increases VEGF production in human cancer cells in vitro and in vivo: implication of RRM2 in angiogenesis. (PMID: 19250552) Zhang K. … Yen Y. (Mol. Cancer 2009) 3 23

Products for THBS1 Gene

Sources for THBS1 Gene

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