Aliases for THBD Gene
Aliases for THBD Gene
External Ids for THBD Gene
- HGNC: 11784
- Entrez Gene: 7056
- Ensembl: ENSG00000178726
- OMIM: 188040
- UniProtKB: P07204
Previous GeneCards Identifiers for THBD Gene
- GC20M023014
- GC20M023021
- GC20M022974
Summaries for THBD Gene
-
The protein encoded by this intronless gene is an endothelial-specific type I membrane receptor that binds thrombin. This binding results in the activation of protein C, which degrades clotting factors Va and VIIIa and reduces the amount of thrombin generated. Mutations in this gene are a cause of thromboembolic disease, also known as inherited thrombophilia. [provided by RefSeq, Jul 2008]
GeneCards Summary for THBD Gene
THBD (Thrombomodulin) is a Protein Coding gene. Diseases associated with THBD include Thrombophilia Due To Thrombomodulin Defect and Hemolytic Uremic Syndrome, Atypical 6. Among its related pathways are Complement and coagulation cascades and Response to elevated platelet cytosolic Ca2+. Gene Ontology (GO) annotations related to this gene include calcium ion binding and transmembrane signaling receptor activity. An important paralog of this gene is CD93.
UniProtKB/Swiss-Prot for THBD Gene
-
Thrombomodulin is a specific endothelial cell receptor that forms a 1:1 stoichiometric complex with thrombin. This complex is responsible for the conversion of protein C to the activated protein C (protein Ca). Once evolved, protein Ca scissions the activated cofactors of the coagulation mechanism, factor Va and factor VIIIa, and thereby reduces the amount of thrombin generated.
Additional gene information for THBD Gene
- Monarch Initiative
- Search for THBD at DataMed
- Search for THBD at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for THBD Gene
Genomics for THBD Gene
GeneHancer (GH) Regulatory Elements for THBD Gene
- Top Transcription factor binding sites by QIAGEN in the THBD gene promoter:
Regulatory Element Products
Genomic Locations for THBD Gene
- chr20:23,045,633-23,049,741
- (GRCh38/hg38)
- Size:
- 4,109 bases
- Orientation:
- Minus strand
- chr20:23,026,270-23,030,378
- (GRCh37/hg19)
Genomic View for THBD Gene
- Cytogenetic band:
-
- 20p11.21 by Ensembl
- 20p11.21 by Entrez Gene
- 20p11.21 by HGNC


RefSeq DNA sequence for THBD Gene
Proteins for THBD Gene
-
Protein details for THBD Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P07204-TRBM_HUMAN
- Recommended name:
- Thrombomodulin
- Protein Accession:
- P07204
- Q8IV29
- Q9UC32
Protein attributes for THBD Gene
- Size:
- 575 amino acids
- Molecular mass:
- 60329 Da
- Quaternary structure:
-
- Interacts with ITGAL, ITGAM and ITGB2.
Protein Expression for THBD Gene
Post-translational modifications for THBD Gene
- N-glycosylated.
- The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.
- Glycosylation at posLast=4747, isoforms=115, posLast=116116, isoforms=382, isoforms=409, posLast=490490, and isoforms=492
Other Protein References for THBD Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for THBD (Thrombomodulin/BDCA-3)
-
Custom Antibody ServicesOriGene Antibodies for THBD
- Novus Biologicals Antibodies for THBD
-
Abcam antibodies for THBD
-
Cloud-Clone Corp. Antibodies for THBD
- Invitrogen Antibodies for THBD
- GeneTex THBD antibody for THBD
- Sino Biological Antibodies for THBD
Protein Products
- R&D Systems Proteins and Enzymes for THBD (Thrombomodulin/BDCA-3)
-
OriGene Purified Proteins for THBD
- Search Origene for MassSpec and Protein Over-expression Lysates for THBD
- Origene Custom Protein Services for THBD
- Novus Biologicals proteins for THBD
- Sino Biological Recombinant Proteins for THBD
- Sino Biological Cell Lysates for THBD
-
Cloud-Clone Corp. Proteins for THBD
- GeneTex Proteins for THBD
-
ProSci Proteins for THBD
-
Abcam proteins for THBD
Assay Products
- R&D Systems Luminex Assays, ELISAs, and other biochemical assays for THBD (Thrombomodulin/BDCA-3)
-
Cloud-Clone Corp. Assay Kits for THBD
-
Abcam assays for THBD
No data available for DME Specific Peptides for THBD Gene
Domains & Families for THBD Gene
Gene Families for THBD Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Candidate cardiovascular disease genes
- CD markers
- Disease related genes
- Predicted membrane proteins
Protein Domains for THBD Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for THBD Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P07204UniProtKB/Swiss-Prot:
TRBM_HUMAN :- Extracellular region (481-515) contains a binding side for alpha-L/beta-2 and alpha-M/beta-2 integrin.
- Domain:
-
- Extracellular region (481-515) contains a binding side for alpha-L/beta-2 and alpha-M/beta-2 integrin.
Function for THBD Gene
Molecular function for THBD Gene
- GENATLAS Biochemistry:
- thrombomodulin coagulation factor complexing with thrombin,the complex activating PROC,with mutations in the promoter region putatively associated with a risk for arterial thrombosis and myocardial infarction
- UniProtKB/Swiss-Prot Function:
- Thrombomodulin is a specific endothelial cell receptor that forms a 1:1 stoichiometric complex with thrombin. This complex is responsible for the conversion of protein C to the activated protein C (protein Ca). Once evolved, protein Ca scissions the activated cofactors of the coagulation mechanism, factor Va and factor VIIIa, and thereby reduces the amount of thrombin generated.
Phenotypes From GWAS Catalog for THBD Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004872 | receptor activity | TAS | 2822087 |
GO:0004888 | transmembrane signaling receptor activity | IEA | -- |
GO:0005509 | calcium ion binding | IEA,TAS | -- |
GO:0005515 | protein binding | IPI | 14691232 |
Phenotypes for THBD Gene
- MGI mutant phenotypes for THBD:
-
inferred from 11 alleles
- nervous system phenotype
- normal phenotype
- homeostasis/metabolism phenotype
- respiratory system phenotype
- cardiovascular system phenotype
- mortality/aging
- immune system phenotype
- cellular phenotype
- growth/size/body region phenotype
- digestive/alimentary phenotype
- reproductive system phenotype
- integument phenotype
- embryo phenotype
- hematopoietic system phenotype
- renal/urinary system phenotype
- liver/biliary system phenotype
- GenomeRNAi human phenotypes for THBD:
-
- Increased vaccinia virus (VACV) infection
- Decreased viability in esophageal squamous lineage
- Increased transferrin (TF) endocytosis
- Negative genetic interaction between PTEN-/- and PTEN+/+
- Negative genetic interaction between PTTG1-/- and PTTG1+/+
- Increased cell number in S
- Synthetic lethal with vaccinia virus (VACV) infection
Animal Models for THBD Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for THBD
-
-
ViGene Biosciences lentiviral particle packaged cDNA for THBD gene
-
ViGene Biosciences ready-to-package AAV shRNAs for THBD gene
- Search ViGene Biosciences for THBD
CRISPR Products
-
OriGene CRISPR knockouts for THBD
- Applied Biological Materials CRISPR for THBD
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for THBD
- GenScript: Design CRISPR guide RNA sequences for THBD
miRNA for THBD Gene
- miRTarBase miRNAs that target THBD
-
- hsa-mir-335-5p (MIRT017044)
- hsa-mir-215-5p (MIRT024294)
- hsa-mir-192-5p (MIRT026159)
- hsa-mir-3127-5p (MIRT636176)
- hsa-mir-2115-5p (MIRT636177)
- hsa-mir-6879-5p (MIRT636178)
- hsa-mir-7843-5p (MIRT636179)
- hsa-mir-6735-5p (MIRT636180)
- hsa-mir-4632-5p (MIRT636181)
- hsa-mir-4436b-3p (MIRT636182)
- hsa-mir-578 (MIRT639318)
- hsa-mir-4763-3p (MIRT639319)
- hsa-mir-1207-5p (MIRT639320)
- hsa-mir-6836-5p (MIRT639321)
- hsa-mir-6132 (MIRT639322)
miRNA Products
- Search ViGene Biosciences for THBD
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for THBD
- Browse OriGene Inhibitory RNA Products For THBD
- genomics-online: shRNA clones - Search results for 133 available Thrombomodulin gene related products
- Overview of 133 available Thrombomodulin gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for THBD gene
Clone Products
- Sino Biological Human cDNA Clone for THBD
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for THBD
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for THBD
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for 133 available Thrombomodulin gene related products
- Overview of 133 available Thrombomodulin gene related products
- orf clones - Search results for 133 available Thrombomodulin gene related products
- Overview of 133 available Thrombomodulin gene related products
- Applied Biological Materials Clones for THBD
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
- R&D Systems cDNA Clones for THBD (Thrombomodulin/BDCA-3)
Cell Line Products
-
Horizon Cell Lines for THBD
-
ViGene Biosciences adenoviral particle packaged cDNA for THBD gene
-
ViGene Biosciences lentiviral particle packaged cDNA for THBD gene
-
ViGene Biosciences ready-to-package AAV shRNAs for THBD gene
No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for THBD Gene
Localization for THBD Gene
Subcellular locations from UniProtKB/Swiss-Prot for THBD Gene
- Membrane; Single-pass type I membrane protein.
- Cytosol (2)
- Nucleoplasm (2)
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005615 | extracellular space | IEA | -- |
GO:0005774 | vacuolar membrane | IEA | -- |
GO:0005886 | plasma membrane | IEA,TAS | -- |
GO:0005887 | integral component of plasma membrane | TAS,IEA | -- |
GO:0009986 | cell surface | IDA | 17379830 |
Pathways & Interactions for THBD Gene
Pathways by source for THBD Gene
2 BioSystems pathways for THBD Gene
4 Reactome pathways for THBD Gene
3 KEGG pathways for THBD Gene
2 R&D Systems pathways for THBD Gene
3 Qiagen pathways for THBD Gene
Interacting Proteins for THBD Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0007165 | signal transduction | IEA | -- |
GO:0007565 | female pregnancy | IEA | -- |
GO:0007596 | blood coagulation | TAS | -- |
GO:0007599 | hemostasis | IEA | -- |
GO:0010165 | response to X-ray | IEA | -- |
No data available for SIGNOR curated interactions for THBD Gene
Drugs & Compounds for THBD Gene
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Warfarin | Approved | Pharma | 505 | |||
Dexibuprofen | Approved, Investigational | Pharma | Target, modulator | 0 | ||
Drotrecogin alfa | Approved, Investigational, Withdrawn | Pharma | Target | 0 | ||
Ibuprofen | Approved | Pharma | Channel blocker, Target, modulator | 547 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
---|
Transcripts for THBD Gene
mRNA/cDNA for THBD Gene
- (1) REFSEQ mRNAs :
- (7) Additional mRNA sequences :
- (122) Selected AceView cDNA sequences:
- (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for THBD
- Applied Biological Materials CRISPR for THBD
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for THBD
- GenScript: Design CRISPR guide RNA sequences for THBD
miRNA Products
- Search ViGene Biosciences for THBD
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for THBD
- Browse OriGene Inhibitory RNA Products For THBD
- genomics-online: shRNA clones - Search results for 133 available Thrombomodulin gene related products
- Overview of 133 available Thrombomodulin gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for THBD gene
Clone Products
- Sino Biological Human cDNA Clone for THBD
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for THBD
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for THBD
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for 133 available Thrombomodulin gene related products
- Overview of 133 available Thrombomodulin gene related products
- orf clones - Search results for 133 available Thrombomodulin gene related products
- Overview of 133 available Thrombomodulin gene related products
- Applied Biological Materials Clones for THBD
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
- R&D Systems cDNA Clones for THBD (Thrombomodulin/BDCA-3)
Expression for THBD Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Cartilage (Muscoskeletal System)
- Intervertebral Disc Nucleus Pulposus Cells Nucleus Pulposus
- Mesenchymal Condensate Cells Zeugopod
- Nucleus Pulposus
- Intervertebral Disc
-
Blood (Hematopoietic System)
- Granulocytes Peripheral Blood
- Monocytes Peripheral Blood
-
Lung (Respiratory System)
- Basal Cells Respiratory Bronchioles
- Trachea
-
Peripheral Nervous System (Nervous System)
- Pro-myelinating Schwann Cells Peripheral Nerve Domain
- Immature Schwann Cells Peripheral Nerve Domain
-
Skeletal Muscle (Muscoskeletal System)
- Muscle Progenitor Cells Mandibular Arch Muscles
- Muscle Progenitor Cells Hyoid Arch Muscles
- Bone (Muscoskeletal System)
- NULL (Uncategorized)
-
Epithelial Cells
- Basal Cells Respiratory Bronchioles
-
Hypoblast (Extraembryonic Tissues)
- Extraembryonic Endoderm Cells Extraembryonic Endoderm
-
Yolk Sac (Extraembryonic Tissues)
- Extraembryonic Endoderm Cells Extraembryonic Endoderm
-
Testis (Reproductive System)
- Testicular Interstitial Cells Testis Interstitium
-
Limb (Muscoskeletal System)
- Mesenchymal Condensate Cells Zeugopod
- Brain (Nervous System)
- Primitive Streak (Early Embryonic Tissues)
- Gut Tube (Gastrointestinal Tract)
- Umbilical Cord (Extraembryonic Tissues)
- Extraembryonic Tissues (Extraembryonic Tissues)
- Uncategorized
- Endothelium (Cardiovascular System)
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for THBD Gene
NURSA nuclear receptor signaling pathways regulating expression of THBD Gene:
THBDSOURCE GeneReport for Unigene cluster for THBD Gene:
Hs.2030mRNA Expression by UniProt/SwissProt for THBD Gene:
P07204-TRBM_HUMANEvidence on tissue expression from TISSUES for THBD Gene
- Lung(4.7)
- Nervous system(4.5)
- Heart(3.5)
- Blood(3.2)
- Spleen(3.2)
- Lymph node(2.6)
- Muscle(2.5)
- Skin(2.5)
- Kidney(2.2)
- Liver(2.1)
- Pancreas(2.1)
- Bone marrow(2)
- Intestine(2)
Phenotype-based relationships between genes and organs from Gene ORGANizer for THBD Gene
- ectoderm
- endoderm
- mesoderm
- cardiovascular
- digestive
- immune
- integumentary
- nervous
- respiratory
- urinary
- brain
- ear
- head
- heart
- lung
- kidney
- liver
- pancreas
- blood
- blood vessel
- coagulation system
- red blood cell
- skin
Primer Products
-
OriGene qPCR primer pairs for THBD
-
OriGene qPCR primer pairs and template standards for THBD
- genomics-online: primer clones - Search results for 133 available Thrombomodulin gene related products
- Overview of 133 available Thrombomodulin gene related products
No data available for mRNA differential expression in normal tissues and Protein tissue co-expression partners for THBD Gene
Orthologs for THBD Gene
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
chimpanzee (Pan troglodytes) |
Mammalia | THBD 33 34 |
|
||
dog (Canis familiaris) |
Mammalia | THBD 33 34 |
|
||
cow (Bos Taurus) |
Mammalia | THBD 33 34 |
|
||
mouse (Mus musculus) |
Mammalia | Thbd 33 16 34 |
|
||
rat (Rattus norvegicus) |
Mammalia | Thbd 33 |
|
||
oppossum (Monodelphis domestica) |
Mammalia | THBD 34 |
|
OneToOne | |
platypus (Ornithorhynchus anatinus) |
Mammalia | THBD 34 |
|
OneToOne | |
chicken (Gallus gallus) |
Aves | THBD 33 34 |
|
||
tropical clawed frog (Silurana tropicalis) |
Amphibia | thbd 33 |
|
||
zebrafish (Danio rerio) |
Actinopterygii | THBD 34 |
|
OneToOne |
- Species where no ortholog for THBD was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for THBD Gene
Variants for THBD Gene
SNP ID | Clin | Chr 20 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs1039499682 | uncertain-significance, Atypical hemolytic uremic syndrome | 23,045,908(-) | C/T | 3_prime_UTR_variant | |
rs1042579 | benign, Atypical hemolytic uremic syndrome | 23,048,087(-) | G/A/T | coding_sequence_variant, missense_variant | |
rs1042580 | benign, Atypical hemolytic uremic syndrome | 23,046,984(-) | T/C | 3_prime_UTR_variant | |
rs113252822 | likely-benign, Atypical hemolytic uremic syndrome | 23,046,007(-) | A/G | 3_prime_UTR_variant | |
rs11696919 | likely-benign, Atypical hemolytic uremic syndrome | 23,047,426(-) | T/C | 3_prime_UTR_variant |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv2758789 | CNV | loss | 17122850 |
nsv482065 | CNV | gain | 20164927 |
Additional Variant Information for THBD Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for THBD Gene
Disorders for THBD Gene

(77) MalaCards diseases for THBD Gene - From: HGMD, OMIM, ClinVar, GTR, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards
Disorder | Aliases | PubMed IDs |
---|---|---|
thrombophilia due to thrombomodulin defect |
|
|
hemolytic uremic syndrome, atypical 6 |
|
|
thrombosis |
|
|
dengue shock syndrome |
|
|
sarcomatoid mesothelioma |
|
|
UniProtKB/Swiss-Prot
TRBM_HUMAN- Hemolytic uremic syndrome atypical 6 (AHUS6) [MIM:612926]: An atypical form of hemolytic uremic syndrome. It is a complex genetic disease characterized by microangiopathic hemolytic anemia, thrombocytopenia, renal failure and absence of episodes of enterocolitis and diarrhea. In contrast to typical hemolytic uremic syndrome, atypical forms have a poorer prognosis, with higher death rates and frequent progression to end-stage renal disease. {ECO:0000269 PubMed:19625716, ECO:0000269 PubMed:20513133}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry. Other genes may play a role in modifying the phenotype.
- Thrombophilia due to thrombomodulin defect (THPH12) [MIM:614486]: A hemostatic disorder characterized by a tendency to thrombosis. {ECO:0000269 PubMed:12139752, ECO:0000269 PubMed:7811989, ECO:0000269 PubMed:9198186}. Note=The disease may be caused by mutations affecting the gene represented in this entry. The role of thrombomodulin in thrombosis is controversial. It is likely that genetic or environmental risk factors in addition to THBD variation are involved in the pathogenesis of venous thrombosis.
Genatlas disease for THBD Gene
Additional Disease Information for THBD
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Publications for THBD Gene
- Thrombomodulin mutations in atypical hemolytic-uremic syndrome. (PMID: 19625716) Delvaeye M … Conway EM (The New England journal of medicine 2009) 3 4 22 44 58
- Thrombomodulin Ala455Val polymorphism and risk of coronary heart disease. (PMID: 11245641) Wu KK … Atherosclerosis Risk in Communities Study (ARIC) Investigators (Circulation 2001) 3 4 22 44 58
- Mutations in alternative pathway complement proteins in American patients with atypical hemolytic uremic syndrome. (PMID: 20513133) Maga TK … Smith RJ (Human mutation 2010) 3 4 44 58
- Thrombomodulin gene polymorphisms or haplotypes as potential risk factors for venous thromboembolism: a population-based case-control study. (PMID: 15842356) Heit JA … Melton LJ (Journal of thrombosis and haemostasis : JTH 2005) 3 22 44 58
- Genetic risk for restenosis after coronary balloon angioplasty. (PMID: 15135268) Horibe H … Yokota M (Atherosclerosis 2004) 3 22 44 58
Products for THBD Gene
- R&D Systems Antibodies for THBD (Thrombomodulin/BDCA-3)
- R&D Systems Proteins and Enzymes for THBD (Thrombomodulin/BDCA-3)
- R&D Systems ELISAs, Luminex Assays, and other biochemical assays for THBD (Thrombomodulin/BDCA-3)
- R&D Systems cDNA Clones for THBD (Thrombomodulin/BDCA-3)
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody ServicesOriGene Antibodies for THBD
- Custom Assay ServicesOriGene ELISA Kits for THBD
- OriGene Purified Proteins for THBD
- Search Origene for MassSpec and Protein Over-expression Lysates for THBD
- Origene Custom Protein Services for THBD
- Origene shrna, sirna, and RNAi products in human, mouse, rat for THBD
- Browse OriGene Inhibitory RNA Products For THBD
- OriGene qPCR primer pairs and template standards for THBD
- OriGene qPCR primer pairs for THBD
- OriGene CRISPR knockouts for THBD
- OriGene ORF clones in human for THBD
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For THBD
- GenScript: Next-day shipping of latest version cDNA ORF clones for THBD in any vector
- GenScript Custom Purified and Recombinant Proteins Services for THBD
- GenScript Custom Assay Services for THBD
- GenScript Custom overexpressing Cell Line Services for THBD
- GenScript: Design CRISPR guide RNA sequences for THBD
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for THBD
- Sino Biological Human cDNA Clone for THBD
- Sino Biological Cell Lysates for THBD
- Sino Biological Recombinant Proteins for THBD
- Sino Biological Antibodies for THBD
- Browse Sino Biological Assays
- Browse Sino Biological ELISA Kits
- Browse Sino Biological ELISA Pair Sets
- Browse Sino Biological CRO Services
- Browse Sino Biological Control Vectors
- Sino Biological Transfection Reagent
- Sino Biological Anti-His Tag Antibody
- Novus Biologicals Antibodies for THBD
- Novus Biologicals proteins for THBD
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Abcam antibodies for THBD
- Abcam proteins for THBD
- Abcam assays for THBD
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- Cloud-Clone Corp. Antibodies for THBD
- Cloud-Clone Corp. Proteins for THBD
- Cloud-Clone Corp. Assay Kits for THBD
- Browse Knockouts at Cloud-Clone Corp.
- Browse Knockins at Cloud-Clone Corp.
- Cloud-Clone Corp. disease models service
- Browse cDNA clones at Cloud-Clone Corp.
- Browse primers at Cloud-Clone Corp.
- Cloud-Clone Corp. primary cells service
- Invitrogen Antibodies for THBD
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Cyagen custom Knockout/knockin (KOKI) mouse models for THBD
- VectorBuilder custom plasmid, inducible vectors for THBD
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for THBD
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 266 available Thrombomodulin Antibodies ranked by validation data
- Compare Top Thrombomodulin Antibodies
- antibodies-online: Search results for 91 available Thrombomodulin Elisa Kits ranked by validation data
- Compare Top Thrombomodulin Elisa Kits
- Quality Products:
- antibodies-online: Search results for 25 available Thrombomodulin Proteins ranked by validation data
- Compare Top Thrombomodulin Proteins
- GeneTex THBD antibody for THBD
- GeneTex Proteins for THBD
- ViGene Biosciences adenoviral particle packaged cDNA for THBD gene
- ViGene Biosciences lentiviral particle packaged cDNA for THBD gene
- ViGene Biosciences ready-to-package AAV shRNAs for THBD gene
- Search ViGene Biosciences for THBD
- Search Santa Cruz Biotechnology (SCBT) for THBD siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for THBD
- Search for THBD Antibodies at ProSci
- Custom Antibody Services
- ProSci Proteins for THBD
- Horizon Cell Lines for THBD
- genomics-online: cdna clones - Search results for 133 available Thrombomodulin gene related products
- Overview of 133 available Thrombomodulin gene related products
- orf clones - Search results for 133 available Thrombomodulin gene related products
- Overview of 133 available Thrombomodulin gene related products
- genomics-online: gRNA clones - Search results for 133 available Thrombomodulin gene related products
- Overview of 133 available Thrombomodulin gene related products
- genomics-online: primer clones - Search results for 133 available Thrombomodulin gene related products
- Overview of 133 available Thrombomodulin gene related products
- genomics-online: shRNA clones - Search results for 133 available Thrombomodulin gene related products
- Overview of 133 available Thrombomodulin gene related products
Sources for THBD Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew