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Aliases for THAP9 Gene

Aliases for THAP9 Gene

  • THAP Domain Containing 9 2 3 5
  • THAP Domain-Containing Protein 9 3 4
  • HTh9 3 4
  • EC 2.7.7.- 4

External Ids for THAP9 Gene

Previous GeneCards Identifiers for THAP9 Gene

  • GC04P084214
  • GC04P084280
  • GC04P084179
  • GC04P084040
  • GC04P083821
  • GC04P079563

Summaries for THAP9 Gene

GeneCards Summary for THAP9 Gene

THAP9 (THAP Domain Containing 9) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding and transferase activity. An important paralog of this gene is THAP6.

UniProtKB/Swiss-Prot for THAP9 Gene

  • Active transposase that specifically recognizes the bipartite 5-TXXGGGX(A/T)-3 consensus motif and mediates transposition.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for THAP9 Gene

Genomics for THAP9 Gene

Regulatory Elements for THAP9 Gene

Enhancers for THAP9 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around THAP9 on UCSC Golden Path with GeneCards custom track

Genomic Location for THAP9 Gene

82,900,684 bp from pter
82,920,283 bp from pter
19,600 bases
Plus strand

Genomic View for THAP9 Gene

Genes around THAP9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
THAP9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for THAP9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for THAP9 Gene

Proteins for THAP9 Gene

  • Protein details for THAP9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    DNA transposase THAP9
    Protein Accession:
    Secondary Accessions:
    • B3KRE2
    • Q59AC9

    Protein attributes for THAP9 Gene

    903 amino acids
    Molecular mass:
    103411 Da
    Quaternary structure:
    No Data Available
    • Able to mediate mobilization of P-elements when transfected in Drosophila.

neXtProt entry for THAP9 Gene

Proteomics data for THAP9 Gene at MOPED

Post-translational modifications for THAP9 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for THAP9 Gene

No data available for DME Specific Peptides for THAP9 Gene

Domains & Families for THAP9 Gene

Gene Families for THAP9 Gene

Protein Domains for THAP9 Gene


Suggested Antigen Peptide Sequences for THAP9 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 THAP-type zinc finger.
  • Contains 1 THAP-type zinc finger.
genes like me logo Genes that share domains with THAP9: view

Function for THAP9 Gene

Molecular function for THAP9 Gene

UniProtKB/Swiss-Prot Function:
Active transposase that specifically recognizes the bipartite 5-TXXGGGX(A/T)-3 consensus motif and mediates transposition.

Enzyme Numbers (IUBMB) for THAP9 Gene

Gene Ontology (GO) - Molecular Function for THAP9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004803 transposase activity IDA 23349291
genes like me logo Genes that share ontologies with THAP9: view

Phenotypes for THAP9 Gene

genes like me logo Genes that share phenotypes with THAP9: view

Animal Model Products

CRISPR Products

miRNA for THAP9 Gene

miRTarBase miRNAs that target THAP9

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for THAP9 Gene

Localization for THAP9 Gene

Subcellular locations from

Jensen Localization Image for THAP9 Gene COMPARTMENTS Subcellular localization image for THAP9 gene
Compartment Confidence
mitochondrion 3
nucleus 3
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for THAP9 Gene

Pathways & Interactions for THAP9 Gene

SuperPathways for THAP9 Gene

No Data Available

Interacting Proteins for THAP9 Gene

Gene Ontology (GO) - Biological Process for THAP9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015074 DNA integration IDA 23349291
genes like me logo Genes that share ontologies with THAP9: view

No data available for Pathways by source and SIGNOR curated interactions for THAP9 Gene

Drugs & Compounds for THAP9 Gene

No Compound Related Data Available

Transcripts for THAP9 Gene

Unigene Clusters for THAP9 Gene

THAP domain containing 9:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for THAP9 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9a · 9b
SP1: - - - - -
SP3: - -
SP4: - - -
SP6: - - -

Relevant External Links for THAP9 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for THAP9 Gene

mRNA expression in normal human tissues for THAP9 Gene

SOURCE GeneReport for Unigene cluster for THAP9 Gene Hs.582050

genes like me logo Genes that share expression patterns with THAP9: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for THAP9 Gene

Orthologs for THAP9 Gene

This gene was present in the common ancestor of chordates.

Orthologs for THAP9 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia THAP9 35
  • 88.03 (n)
  • 85.95 (a)
THAP9 36
  • 86 (a)
(Canis familiaris)
Mammalia THAP9 35
  • 90.47 (n)
  • 90.8 (a)
THAP9 36
  • 91 (a)
(Pan troglodytes)
Mammalia THAP9 35
  • 99.67 (n)
  • 99.45 (a)
THAP9 36
  • 99 (a)
(Gallus gallus)
Aves THAP9 35
  • 54.22 (n)
  • 46.1 (a)
THAP9 36
  • 44 (a)
(Anolis carolinensis)
Reptilia THAP9 36
  • 34 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100493283 35
  • 40.92 (n)
  • 26.07 (a)
(Danio rerio)
Actinopterygii LOC101883007 35
  • 45.57 (n)
  • 33.76 (a)
THAP9 (1 of 3) 36
  • 28 (a)
THAP9 (2 of 3) 36
  • 28 (a)
THAP9 (3 of 3) 36
  • 27 (a)
Species with no ortholog for THAP9:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for THAP9 Gene

Gene Tree for THAP9 (if available)
Gene Tree for THAP9 (if available)

Paralogs for THAP9 Gene

Paralogs for THAP9 Gene

(2) SIMAP similar genes for THAP9 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with THAP9: view

Variants for THAP9 Gene

Sequence variations from dbSNP and Humsavar for THAP9 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs1031639 - 82,917,064(-) AGAGG(C/T)ATACT reference, missense
rs897945 - 82,917,109(-) CCCTG(A/C)AAACT reference, missense
rs6535411 - 82,918,646(+) ATATT(A/G)ATCTT reference, missense
rs35532215 - 82,918,709(+) ACTTT(A/G)TCAAG reference, missense
rs1026452 -- 82,915,096(-) tcttc(A/G)acaaa intron-variant

Variation tolerance for THAP9 Gene

Residual Variation Intolerance Score: 30.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.20; 84.85% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for THAP9 Gene

Disorders for THAP9 Gene

Relevant External Links for THAP9

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for THAP9 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for THAP9 Gene

Publications for THAP9 Gene

  1. The human THAP9 gene encodes an active P-element DNA transposase. (PMID: 23349291) Majumdar S. … Rio D.C. (Science 2013) 3 4 67
  2. The THAP domain: a novel protein motif with similarity to the DNA-binding domain of P element transposase. (PMID: 12575992) Roussigne M. … Girard J.P. (Trends Biochem. Sci. 2003) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  5. THAP proteins target specific DNA sites through bipartite recognition of adjacent major and minor grooves. (PMID: 20010837) Sabogal A. … Rio D.C. (Nat. Struct. Mol. Biol. 2010) 3

Products for THAP9 Gene

Sources for THAP9 Gene