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Aliases for THAP9 Gene

Aliases for THAP9 Gene

  • THAP Domain Containing 9 2 3
  • THAP Domain-Containing Protein 9 3 4
  • HTh9 3 4
  • DNA Transposase THAP9 3
  • EC 2.7.7.- 4

External Ids for THAP9 Gene

Previous GeneCards Identifiers for THAP9 Gene

  • GC04P084214
  • GC04P084280
  • GC04P084179
  • GC04P084040
  • GC04P083821
  • GC04P079563

Summaries for THAP9 Gene

GeneCards Summary for THAP9 Gene

THAP9 (THAP Domain Containing 9) is a Protein Coding gene. GO annotations related to this gene include sequence-specific DNA binding and transposase activity. An important paralog of this gene is THAP6.

UniProtKB/Swiss-Prot for THAP9 Gene

  • Active transposase that specifically recognizes the bipartite 5-TXXGGGX(A/T)-3 consensus motif and mediates transposition.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for THAP9 Gene

Genomics for THAP9 Gene

Regulatory Elements for THAP9 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for THAP9 Gene

82,900,684 bp from pter
82,920,131 bp from pter
19,448 bases
Plus strand

Genomic View for THAP9 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for THAP9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for THAP9 Gene

Proteins for THAP9 Gene

  • Protein details for THAP9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    DNA transposase THAP9
    Protein Accession:
    Secondary Accessions:
    • B3KRE2
    • Q59AC9

    Protein attributes for THAP9 Gene

    903 amino acids
    Molecular mass:
    103411 Da
    Quaternary structure:
    No Data Available
    • Able to mediate mobilization of P-elements when transfected in Drosophila.

neXtProt entry for THAP9 Gene

Proteomics data for THAP9 Gene at MOPED

Post-translational modifications for THAP9 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for THAP9 Gene

No data available for DME Specific Peptides for THAP9 Gene

Domains for THAP9 Gene

Gene Families for THAP9 Gene

Protein Domains for THAP9 Gene


Suggested Antigen Peptide Sequences for THAP9 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 THAP-type zinc finger.
  • Contains 1 THAP-type zinc finger.
genes like me logo Genes that share domains with THAP9: view

Function for THAP9 Gene

Molecular function for THAP9 Gene

UniProtKB/Swiss-Prot Function:
Active transposase that specifically recognizes the bipartite 5-TXXGGGX(A/T)-3 consensus motif and mediates transposition.

Enzyme Numbers (IUBMB) for THAP9 Gene

Gene Ontology (GO) - Molecular Function for THAP9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0004803 transposase activity IDA 23349291
GO:0016740 transferase activity IEA --
GO:0043565 sequence-specific DNA binding IDA 20010837
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with THAP9: view

Animal Model Products

CRISPR Products

miRNA for THAP9 Gene

miRTarBase miRNAs that target THAP9

No data available for Phenotypes , Animal Models , Transcription Factor Targets and HOMER Transcription for THAP9 Gene

Localization for THAP9 Gene

Subcellular locations from

Jensen Localization Image for THAP9 Gene COMPARTMENTS Subcellular localization image for THAP9 gene
Compartment Confidence
nucleus 3
cytosol 2
mitochondrion 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for THAP9 Gene

Pathways for THAP9 Gene

SuperPathways for THAP9 Gene

No Data Available

Interacting Proteins for THAP9 Gene

Gene Ontology (GO) - Biological Process for THAP9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006310 DNA recombination IDA 23349291
GO:0006313 transposition, DNA-mediated IDA 23349291
GO:0015074 DNA integration IDA 23349291
genes like me logo Genes that share ontologies with THAP9: view

No data available for Pathways by source for THAP9 Gene

Transcripts for THAP9 Gene

Unigene Clusters for THAP9 Gene

THAP domain containing 9:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for THAP9 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9a · 9b
SP1: - - - - -
SP3: - -
SP4: - - -
SP6: - - -

Relevant External Links for THAP9 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for THAP9 Gene

mRNA expression in normal human tissues for THAP9 Gene

SOURCE GeneReport for Unigene cluster for THAP9 Gene Hs.582050

genes like me logo Genes that share expressions with THAP9: view

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Expression partners for THAP9 Gene

Orthologs for THAP9 Gene

This gene was present in the common ancestor of chordates.

Orthologs for THAP9 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia THAP9 35
  • 88.03 (n)
  • 85.95 (a)
THAP9 36
  • 86 (a)
(Canis familiaris)
Mammalia THAP9 35
  • 90.47 (n)
  • 90.8 (a)
THAP9 36
  • 91 (a)
(Pan troglodytes)
Mammalia THAP9 35
  • 99.67 (n)
  • 99.45 (a)
THAP9 36
  • 99 (a)
(Gallus gallus)
Aves THAP9 35
  • 54.22 (n)
  • 46.1 (a)
THAP9 36
  • 44 (a)
(Anolis carolinensis)
Reptilia THAP9 36
  • 34 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100493283 35
  • 40.92 (n)
  • 26.07 (a)
(Danio rerio)
Actinopterygii LOC101883007 35
  • 45.57 (n)
  • 33.76 (a)
THAP9 (1 of 3) 36
  • 28 (a)
THAP9 (2 of 3) 36
  • 28 (a)
THAP9 (3 of 3) 36
  • 27 (a)
Species with no ortholog for THAP9:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for THAP9 Gene

Gene Tree for THAP9 (if available)
Gene Tree for THAP9 (if available)

Paralogs for THAP9 Gene

Paralogs for THAP9 Gene

(2) SIMAP similar genes for THAP9 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with THAP9: view

Variants for THAP9 Gene

Sequence variations from dbSNP and Humsavar for THAP9 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs1471149 -- 82,915,856(-) CATGA(C/T)TTTTT intron-variant
rs3811840 -- 82,905,258(-) GATAA(C/T)TTCAA intron-variant
rs4693527 -- 82,910,367(+) AAACA(C/T)AGTAC intron-variant
rs10022876 -- 82,909,226(+) AAATT(A/G)TAGAT intron-variant
rs11306469 -- 82,910,439(+) TAAAT(-/A)AAAAA intron-variant

Relevant External Links for THAP9 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for THAP9 Gene

Disorders for THAP9 Gene

No disorders were found for THAP9 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for THAP9 Gene

Publications for THAP9 Gene

  1. The THAP domain: a novel protein motif with similarity to the DNA-binding domain of P element transposase. (PMID: 12575992) Roussigne M. … Girard J.P. (Trends Biochem. Sci. 2003) 2 3
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. Homologs of Drosophila P transposons were mobile in zebrafish but have been domesticated in a common ancestor of chicken and human. (PMID: 15616143) Hammer S.E. … Hagemann S. (Mol. Biol. Evol. 2005) 3 4
  4. THAP proteins target specific DNA sites through bipartite recognition of adjacent major and minor grooves. (PMID: 20010837) Sabogal A. … Rio D.C. (Nat. Struct. Mol. Biol. 2010) 3 4
  5. The human THAP9 gene encodes an active P-element DNA transposase. (PMID: 23349291) Majumdar S. … Rio D.C. (Science 2013) 3 4

Products for THAP9 Gene

Sources for THAP9 Gene

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