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Aliases for THAP8 Gene

Aliases for THAP8 Gene

  • THAP Domain Containing 8 2 3 5

External Ids for THAP8 Gene

Previous GeneCards Identifiers for THAP8 Gene

  • GC19M041201
  • GC19M041217
  • GC19M036525
  • GC19M033031

Summaries for THAP8 Gene

GeneCards Summary for THAP8 Gene

THAP8 (THAP Domain Containing 8) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is THAP3.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for THAP8 Gene

Genomics for THAP8 Gene

Regulatory Elements for THAP8 Gene

Enhancers for THAP8 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around THAP8 on UCSC Golden Path with GeneCards custom track

Promoters for THAP8 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around THAP8 on UCSC Golden Path with GeneCards custom track

Genomic Location for THAP8 Gene

36,034,984 bp from pter
36,054,762 bp from pter
19,779 bases
Minus strand

Genomic View for THAP8 Gene

Genes around THAP8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
THAP8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for THAP8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for THAP8 Gene

Proteins for THAP8 Gene

  • Protein details for THAP8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    THAP domain-containing protein 8
    Protein Accession:
    Secondary Accessions:
    • Q0P5Z7
    • Q96M21

    Protein attributes for THAP8 Gene

    274 amino acids
    Molecular mass:
    30082 Da
    Quaternary structure:
    No Data Available

neXtProt entry for THAP8 Gene

Proteomics data for THAP8 Gene at MOPED

Post-translational modifications for THAP8 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for THAP8 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for THAP8 Gene

Domains & Families for THAP8 Gene

Gene Families for THAP8 Gene

Protein Domains for THAP8 Gene


Suggested Antigen Peptide Sequences for THAP8 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 THAP-type zinc finger.
  • Contains 1 THAP-type zinc finger.
genes like me logo Genes that share domains with THAP8: view

Function for THAP8 Gene

Gene Ontology (GO) - Molecular Function for THAP8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with THAP8: view
genes like me logo Genes that share phenotypes with THAP8: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for THAP8 Gene

Localization for THAP8 Gene

Subcellular locations from

Jensen Localization Image for THAP8 Gene COMPARTMENTS Subcellular localization image for THAP8 gene
Compartment Confidence
extracellular 2
cytosol 1
mitochondrion 1
nucleus 1
peroxisome 1
plasma membrane 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for THAP8 Gene

Pathways & Interactions for THAP8 Gene

SuperPathways for THAP8 Gene

No Data Available

Interacting Proteins for THAP8 Gene

Gene Ontology (GO) - Biological Process for THAP8 Gene


No data available for Pathways by source and SIGNOR curated interactions for THAP8 Gene

Drugs & Compounds for THAP8 Gene

No Compound Related Data Available

Transcripts for THAP8 Gene

Unigene Clusters for THAP8 Gene

THAP domain containing 8:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for THAP8 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b
SP2: -
SP4: -

Relevant External Links for THAP8 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for THAP8 Gene

mRNA expression in normal human tissues for THAP8 Gene

SOURCE GeneReport for Unigene cluster for THAP8 Gene Hs.350209

genes like me logo Genes that share expression patterns with THAP8: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for THAP8 Gene

Orthologs for THAP8 Gene

This gene was present in the common ancestor of chordates.

Orthologs for THAP8 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia THAP8 35
  • 80.42 (n)
  • 73.15 (a)
THAP8 36
  • 72 (a)
(Canis familiaris)
Mammalia THAP8 35
  • 77.78 (n)
  • 70.08 (a)
THAP8 36
  • 66 (a)
(Pan troglodytes)
Mammalia THAP8 35
  • 98.02 (n)
  • 96.43 (a)
THAP8 36
  • 97 (a)
(Anolis carolinensis)
Reptilia THAP8 36
  • 61 (a)
(Danio rerio)
Actinopterygii si:ch211-253b1.6 36
  • 13 (a)
Species with no ortholog for THAP8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for THAP8 Gene

Gene Tree for THAP8 (if available)
Gene Tree for THAP8 (if available)

Paralogs for THAP8 Gene

Paralogs for THAP8 Gene

(2) SIMAP similar genes for THAP8 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with THAP8: view

Variants for THAP8 Gene

Sequence variations from dbSNP and Humsavar for THAP8 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
VAR_020264 -
VAR_034552 -
VAR_034553 -
VAR_052288 -
VAR_052289 -

Structural Variations from Database of Genomic Variants (DGV) for THAP8 Gene

Variant ID Type Subtype PubMed ID
nsv911638 CNV Loss 21882294
nsv911641 CNV Loss 21882294
nsv833815 CNV Loss 17160897

Variation tolerance for THAP8 Gene

Residual Variation Intolerance Score: 67.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.87; 87.03% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for THAP8 Gene

Disorders for THAP8 Gene

Relevant External Links for THAP8

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for THAP8 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for THAP8 Gene

Publications for THAP8 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 67
  2. The THAP domain: a novel protein motif with similarity to the DNA-binding domain of P element transposase. (PMID: 12575992) Roussigne M. … Girard J.P. (Trends Biochem. Sci. 2003) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  5. Toward an understanding of the protein interaction network of the human liver. (PMID: 21988832) Wang J. … Yang X. (Mol. Syst. Biol. 2011) 3

Products for THAP8 Gene

Sources for THAP8 Gene