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Aliases for THAP8 Gene

Aliases for THAP8 Gene

  • THAP Domain Containing 8 2 3

External Ids for THAP8 Gene

Previous GeneCards Identifiers for THAP8 Gene

  • GC19M041201
  • GC19M041217
  • GC19M036525
  • GC19M033031

Summaries for THAP8 Gene

GeneCards Summary for THAP8 Gene

THAP8 (THAP Domain Containing 8) is a Protein Coding gene. An important paralog of this gene is THAP3.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for THAP8 Gene

Genomics for THAP8 Gene

Regulatory Elements for THAP8 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for THAP8 Gene

Start:
36,034,984 bp from pter
End:
36,054,762 bp from pter
Size:
19,779 bases
Orientation:
Minus strand

Genomic View for THAP8 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for THAP8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for THAP8 Gene

Proteins for THAP8 Gene

  • Protein details for THAP8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NA92-THAP8_HUMAN
    Recommended name:
    THAP domain-containing protein 8
    Protein Accession:
    Q8NA92
    Secondary Accessions:
    • Q0P5Z7
    • Q96M21

    Protein attributes for THAP8 Gene

    Size:
    274 amino acids
    Molecular mass:
    30082 Da
    Quaternary structure:
    No Data Available

neXtProt entry for THAP8 Gene

Proteomics data for THAP8 Gene at MOPED

Post-translational modifications for THAP8 Gene

No Post-translational modifications

Other Protein References for THAP8 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for THAP8 Gene

Domains for THAP8 Gene

Gene Families for THAP8 Gene

HGNC:
  • THAP :THAP (C2CH-type zinc finger) domain containing

Protein Domains for THAP8 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for THAP8 Gene

Graphical View of Domain Structure for InterPro Entry

Q8NA92

UniProtKB/Swiss-Prot:

THAP8_HUMAN :
  • Q8NA92
Similarity:
  • Contains 1 THAP-type zinc finger.
genes like me logo Genes that share domains with THAP8: view

Function for THAP8 Gene

Gene Ontology (GO) - Molecular Function for THAP8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 25416956
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with THAP8: view

Phenotypes for THAP8 Gene

genes like me logo Genes that share phenotypes with THAP8: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for THAP8

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for THAP8 Gene

Localization for THAP8 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for THAP8 Gene COMPARTMENTS Subcellular localization image for THAP8 gene
Compartment Confidence
extracellular 2
cytosol 1
mitochondrion 1
nucleus 1
peroxisome 1
plasma membrane 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for THAP8 Gene

Pathways for THAP8 Gene

SuperPathways for THAP8 Gene

No Data Available

Interacting Proteins for THAP8 Gene

Gene Ontology (GO) - Biological Process for THAP8 Gene

None

No data available for Pathways by source for THAP8 Gene

Transcripts for THAP8 Gene

Unigene Clusters for THAP8 Gene

THAP domain containing 8:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for THAP8

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for THAP8 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b
SP1:
SP2: -
SP3:
SP4: -

Relevant External Links for THAP8 Gene

GeneLoc Exon Structure for
THAP8
ECgene alternative splicing isoforms for
THAP8

Expression for THAP8 Gene

mRNA expression in normal human tissues for THAP8 Gene

SOURCE GeneReport for Unigene cluster for THAP8 Gene Hs.350209

genes like me logo Genes that share expressions with THAP8: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein expression and mRNA Expression by UniProt/SwissProt for THAP8 Gene

Orthologs for THAP8 Gene

This gene was present in the common ancestor of chordates.

Orthologs for THAP8 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia THAP8 35
  • 98.02 (n)
  • 96.43 (a)
THAP8 36
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia THAP8 35
  • 80.42 (n)
  • 73.15 (a)
THAP8 36
  • 72 (a)
OneToOne
dog
(Canis familiaris)
Mammalia THAP8 35
  • 77.78 (n)
  • 70.08 (a)
THAP8 36
  • 66 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia THAP8 36
  • 61 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii si:ch211-253b1.6 36
  • 13 (a)
ManyToMany
Species with no ortholog for THAP8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for THAP8 Gene

ENSEMBL:
Gene Tree for THAP8 (if available)
TreeFam:
Gene Tree for THAP8 (if available)

Paralogs for THAP8 Gene

Paralogs for THAP8 Gene

Selected SIMAP similar genes for THAP8 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with THAP8: view

Variants for THAP8 Gene

Sequence variations from dbSNP and Humsavar for THAP8 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs1009381 -- 36,047,057(+) GCAAT(A/G)TTGCT intron-variant
rs4806256 -- 36,047,969(+) GCTGT(C/T)TCTCT intron-variant
rs7245415 -- 36,049,736(+) aacta(C/T)tgttg intron-variant
rs7245686 -- 36,050,118(+) ATGAG(A/T)AGTAG intron-variant
rs7250448 -- 36,052,511(+) tgttt(G/T)gtgag intron-variant

Structural Variations from Database of Genomic Variants (DGV) for THAP8 Gene

Variant ID Type Subtype PubMed ID
nsv911638 CNV Loss 21882294
nsv911641 CNV Loss 21882294
nsv833815 CNV Loss 17160897

Relevant External Links for THAP8 Gene

HapMap Linkage Disequilibrium report
THAP8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for THAP8 Gene

Disorders for THAP8 Gene

No disorders were found for THAP8 Gene.

No data available for UniProtKB/Swiss-Prot for THAP8 Gene

Publications for THAP8 Gene

  1. The THAP domain: a novel protein motif with similarity to the DNA-binding domain of P element transposase. (PMID: 12575992) Roussigne M. … Girard J.P. (Trends Biochem. Sci. 2003) 2 3
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. A human protein-protein interaction network: a resource for annotating the proteome. (PMID: 16169070) Stelzl U. … Wanker E.E. (Cell 2005) 3
  5. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3

Products for THAP8 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate THAP8
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for THAP8
    • Block miRNA regulation of THAP8 using miScript Target Protectors

    Sources for THAP8 Gene

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