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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

THAP7 Gene

protein-coding   GIFtS: 47
GCID: GC22M021353

THAP Domain Containing 7

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
THAP Domain Containing 71 2
THAP Domain-Containing Protein 72

External Ids:    HGNC: 231901   Entrez Gene: 807642   Ensembl: ENSG000001844367   OMIM: 6095185   UniProtKB: Q9BT493   
ORGUL members:         
NONCODE14:n337964      

Export aliases for THAP7 gene to outside databases

Previous GC identifers: GC22M019678 GC22M004622


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for THAP7 Gene: 
THAP7 (THAP domain containing 7) is a protein-coding gene, and is affiliated with the lncRNA class. Diseases associated with THAP7 include gastric cancer. GO annotations related to this gene include C2H2 zinc finger domain binding and protein N-terminus binding.

UniProtKB/Swiss-Prot: THAP7_HUMAN, Q9BT49
Function: Chromatin-associated, histone tail-binding protein that represses transcription via recruitment of HDAC3
and nuclear hormone receptor corepressors

Gene Wiki entry for THAP7 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000022.10  NC_018933.2  NT_011520.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the THAP7 gene promoter:
         p53   Lmo2   MyoD   Olf-1   Pax-2   CUTL1   Pax-2a   MIF-1   c-Ets-1   Pax-2b   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTHAP7 promoter sequence
   Search SABiosciences Chromatin IP Primers for THAP7

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat THAP7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q11.2   Ensembl cytogenetic band:  22q11.21   HGNC cytogenetic band: 22q11.2

THAP7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
THAP7 gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22M021353:  view genomic region     (about GC identifiers)

Start:
21,353,393 bp from pter      End:
21,356,485 bp from pter
Size:
3,093 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: THAP7_HUMAN, Q9BT49 (See protein sequence)
Recommended Name: THAP domain-containing protein 7  
Size: 309 amino acids; 34414 Da
Subunit: Interacts with HDAC3 and nuclear hormone receptor corepressors
Subcellular location: Nucleus. Chromosome
Secondary accessions: B2RD97 D3DX40

Explore the universe of human proteins at neXtProt for THAP7: NX_Q9BT49

Explore proteomics data for THAP7 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9BT49

  • THAP7 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    THAP7 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001008695.1  NP_085050.2  

    ENSEMBL proteins: 
     ENSP00000215742   ENSP00000382084  

    Human Recombinant Protein Products for THAP7: 
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    Browse Sino Biological Cell Lysates 
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    Cloud-Clone Corp. Proteins for THAP7 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005694chromosome IEA--
    GO:0016607nuclear speck IDA17577209

    THAP7 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    THAP: THAP (C2CH-type zinc finger) domain containing

    2 InterPro protein domains:
     IPR026519 THAP7
     IPR006612 Znf_C2CH

    Graphical View of Domain Structure for InterPro Entry Q9BT49

    ProtoNet protein and cluster: Q9BT49

    UniProtKB/Swiss-Prot: THAP7_HUMAN, Q9BT49
    Similarity: Contains 1 THAP-type zinc finger


    THAP7 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: THAP7_HUMAN, Q9BT49
    Function: Chromatin-associated, histone tail-binding protein that represses transcription via recruitment of HDAC3
    and nuclear hormone receptor corepressors

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0046872metal ion binding IEA--
    GO:0047485protein N-terminus binding IPI17577209
    GO:0070742C2H2 zinc finger domain binding IDA17577209
         
    THAP7 for ontologies           About GeneDecksing


    Animal Models:
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for THAP7

    STRING Interaction Network Preview (showing 5 interactants - click image to see 19)

    5/52 Interacting proteins for THAP7 (Q9BT492, 3 ENSP000002157424) via UniProtKB, MINT, STRING, and/or I2D (see all 52)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053, ENSP000003529804I2D: score=1 STRING: ENSP00000352980
    HIST1H4BP628053I2D: score=1 
    HIST1H4CP628053I2D: score=1 
    HIST1H4DP628053I2D: score=1 
    HIST1H4EP628053I2D: score=1 
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0045892negative regulation of transcription, DNA-dependent IDA17577209

    THAP7 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for THAP7

    Search CenterWatch for drugs/clinical trials and news about THAP7

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for THAP7 gene (3 alternative transcripts): 
    NM_001008696.1  NM_001008695.1  NM_030573.2  

    Unigene Cluster for THAP7:

    THAP domain containing 7
    Hs.512756  [show with all ESTs]
    Unigene Representative Sequence: AK024609
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000498406 ENST00000215742(uc002zts.1) ENST00000471073 ENST00000399133(uc002ztr.1)
    ENST00000476667 ENST00000466670 ENST00000488975 ENST00000471723
    miRNA
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    Additional mRNA sequence: 

    AK024609.1 AK025906.1 AK300715.1 AK315457.1 BC004346.1 CR456343.1 

    21 DOTS entries:

    DT.100844487  DT.452213  DT.102840430  DT.85105373  DT.100711945  DT.100844474  DT.100844478  DT.100844491 
    DT.100658699  DT.100772056  DT.97807924  DT.97845803  DT.95221873  DT.120667977  DT.97845804  DT.100663213 
    DT.100802112  DT.100808092  DT.100844488  DT.75176386  DT.108347 

    24/257 AceView cDNA sequences (see all 257):

    AI686972 CR456343 CR611968 BM919759 AW246698 BE207070 BC004346 BQ944953 
    CR614644 BU552453 BF972786 BU782953 BG762824 CA313778 CR594608 BP368954 
    AA403296 AW025197 BG760461 CB242040 BX099067 CR605890 BQ267940 AI890725 

    GeneLoc Exon Structure

    5/10 Alternative Splicing Database (ASD) splice patterns (SP) for THAP7 (see all 10)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b · 3c · 3d · 3e ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b · 6c ^ 7a · 7b · 7c · 7d · 7e · 7f · 7g
    SP1:                    -           -     -     -     -     -     -     -                 -                                                               
    SP2:                    -           -     -     -     -     -     -     -           -     -     -                                                         
    SP3:                                -     -     -     -     -     -     -                 -                                                               
    SP4:                                                              -     -                 -                                                               
    SP5:                                                        -     -     -                 -                                                               


    ECgene alternative splicing isoforms for THAP7

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    THAP7 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCCTGAGGGG
    THAP7 Expression
    About this image


    See THAP7 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for THAP7

    SOURCE GeneReport for Unigene cluster: Hs.512756
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for THAP7 gene from 5/9 species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Thap71 , 5 THAP domain containing 71, 5 89(n)1
    92.88(a)1
      16 (10.86 cM)5
    690091  NM_026909.21  NP_081185.11 
     175279825 
    chicken
    (Gallus gallus)
    Aves THAP71 THAP domain containing 7 64.95(n)
    64.82(a)
      776094  XM_001235649.2  XP_001235650.2 
    lizard
    (Anolis carolinensis)
    Reptilia THAP76
    THAP domain containing 7
    57(a)
    1 ↔ 1
    6(78771256-78775854)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.102372 Transcribed sequence with moderate similarity to protein more 69.6(n)    BX689880.1 
    zebrafish
    (Danio rerio)
    Actinopterygii thap71 THAP domain containing 7 49.31(n)
    45.66(a)
      100006965  NM_001103198.1  NP_001096668.1 


    ENSEMBL Gene Tree for THAP7 (if available)
    TreeFam Gene Tree for THAP7 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/13 SNPs in THAP7 are shown (see all 13)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 22 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0602774
    ----see VAR_0602772 A P mis40--------
    rs37470841,2
    C,F,H--21353925(+) TCTGAG/AGGGTG 2 -- ds500119Minor allele frequency- A:0.08EA NS NA CSA WA 4008
    rs1862100171,2
    C--21354151(+) CCCTCG/AGTCAG 2 -- ut311Minor allele frequency- A:0.00EU 995
    rs2018718071,2
    --21354152(+) CCTCGA/GTCAGT 2 -- ut310--------
    rs125741,2
    C,F--21354158(+) TCAGTC/GCAGCA 2 -- ut31 ese34Minor allele frequency- G:0.02MN NA WA EU 1403
    rs3734912811,2
    ----21354164(+) CAGCAA/GCCCTC 2 -- ut310--------
    rs3683711481,2
    ----21354178(+) GCCATA/GCTGCT 4 S syn10--------
    rs3750310701,2
    ----21354166(+) GCAGCC/TCCTCA 2 -- ut310--------
    rs3706402951,2
    ----21354165(+) AGCAGC/TCCCTC 2 -- ut310--------
    rs2001090891,2
    ----21354125(+) AAGAGG/ACTGCA 2 -- ut311Minor allele frequency- A:0.00EU 353

    HapMap Linkage Disequilibrium report for THAP7 (21353393 - 21356485 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/15 variations for THAP7 (see all 15):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2678175CNV Deletion23128226
    nsv436864CNV Insertion17901297
    nsv834141CNV Loss17160897
    nsv523162CNV Loss19592680
    nsv914428CNV Loss21882294
    dgv4872n71CNV Loss21882294
    nsv828960CNV Loss20364138
    nsv471185CNV Loss18288195
    dgv4873n71CNV Loss21882294
    nsv914423CNV Gain21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 609518    OMIM disorders: --

    2 diseases for THAP7:    About MalaCards
    gastric cancer    


    THAP7 for disorders           About GeneDecksing


    Export disorders for THAP7 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for THAP7 gene, integrated from 9 sources (see all 18):
    (articles sorted by number of sources associating them with THAP7)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human THAP7 is a chromatin-associated, histone tail-binding protein that represses transcription via recruitment of HDAC3 and nuclear hormone receptor corepressor. (PubMed id 15561719)1, 2 Macfarlan T....Chakravarti D. (2005)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802)1, 2 Collins J.E.... Dunham I. (2004)
    4. The THAP domain: a novel protein motif with similarity to the DNA-binding domain of P element transposase. (PubMed id 12575992)1, 3 Roussigne M....Girard J.P. (2003)
    5. Thanatos-associated protein 7 associates with template activating factor-Ibeta and inhibits histone acetylation to repress transcription. (PubMed id 16195249)1, 9 Macfarlan T....Chakravarti D. (2006)
    6. A directed protein interaction network for investigat ing intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (2011)
    7. Toward an understanding of the protein interaction net work of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (2011)
    8. Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
    9. An atlas of combinatorial transcriptional regulation in mouse and man. (PubMed id 20211142)1 Ravasi T....Hayashizaki Y. (2010)
    10. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 80764 HGNC: 23190 AceView: THAP7 Ensembl:ENSG00000184436 euGenes: HUgn80764
    ECgene: THAP7 H-InvDB: THAP7

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for THAP7 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for THAP7 gene:
    Search GeneIP for patents involving THAP7

    GeneCards and IP:
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    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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