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Aliases for THAP7 Gene

Aliases for THAP7 Gene

  • THAP Domain Containing 7 2 3 5

External Ids for THAP7 Gene

Previous GeneCards Identifiers for THAP7 Gene

  • GC22M019678
  • GC22M021353
  • GC22M004622

Summaries for THAP7 Gene

GeneCards Summary for THAP7 Gene

THAP7 (THAP Domain Containing 7) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding and C2H2 zinc finger domain binding.

UniProtKB/Swiss-Prot for THAP7 Gene

  • Chromatin-associated, histone tail-binding protein that represses transcription via recruitment of HDAC3 and nuclear hormone receptor corepressors.

Gene Wiki entry for THAP7 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for THAP7 Gene

Genomics for THAP7 Gene

Regulatory Elements for THAP7 Gene

Enhancers for THAP7 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around THAP7 on UCSC Golden Path with GeneCards custom track

Promoters for THAP7 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around THAP7 on UCSC Golden Path with GeneCards custom track

Genomic Location for THAP7 Gene

Chromosome:
22
Start:
20,999,104 bp from pter
End:
21,002,196 bp from pter
Size:
3,093 bases
Orientation:
Minus strand

Genomic View for THAP7 Gene

Genes around THAP7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
THAP7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for THAP7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for THAP7 Gene

Proteins for THAP7 Gene

  • Protein details for THAP7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BT49-THAP7_HUMAN
    Recommended name:
    THAP domain-containing protein 7
    Protein Accession:
    Q9BT49
    Secondary Accessions:
    • B2RD97
    • D3DX40

    Protein attributes for THAP7 Gene

    Size:
    309 amino acids
    Molecular mass:
    34414 Da
    Quaternary structure:
    • Interacts with HDAC3 and nuclear hormone receptor corepressors.

neXtProt entry for THAP7 Gene

Proteomics data for THAP7 Gene at MOPED

Post-translational modifications for THAP7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for THAP7 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for THAP7 Gene

Domains & Families for THAP7 Gene

Gene Families for THAP7 Gene

Protein Domains for THAP7 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for THAP7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BT49

UniProtKB/Swiss-Prot:

THAP7_HUMAN :
  • Contains 1 THAP-type zinc finger.
Similarity:
  • Contains 1 THAP-type zinc finger.
genes like me logo Genes that share domains with THAP7: view

Function for THAP7 Gene

Molecular function for THAP7 Gene

UniProtKB/Swiss-Prot Function:
Chromatin-associated, histone tail-binding protein that represses transcription via recruitment of HDAC3 and nuclear hormone receptor corepressors.

Gene Ontology (GO) - Molecular Function for THAP7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0047485 protein N-terminus binding IPI 17577209
genes like me logo Genes that share ontologies with THAP7: view
genes like me logo Genes that share phenotypes with THAP7: view

Animal Model Products

miRNA for THAP7 Gene

miRTarBase miRNAs that target THAP7

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for THAP7 Gene

Localization for THAP7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for THAP7 Gene

Nucleus. Chromosome.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for THAP7 Gene COMPARTMENTS Subcellular localization image for THAP7 gene
Compartment Confidence
nucleus 5
extracellular 2
cytosol 1
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for THAP7 Gene

Pathways & Interactions for THAP7 Gene

SuperPathways for THAP7 Gene

No Data Available

Gene Ontology (GO) - Biological Process for THAP7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0045892 negative regulation of transcription, DNA-templated IDA 17577209
genes like me logo Genes that share ontologies with THAP7: view

No data available for Pathways by source and SIGNOR curated interactions for THAP7 Gene

Drugs & Compounds for THAP7 Gene

No Compound Related Data Available

Transcripts for THAP7 Gene

Unigene Clusters for THAP7 Gene

THAP domain containing 7:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for THAP7 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b · 3c · 3d · 3e ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b · 6c ^ 7a · 7b · 7c · 7d · 7e · 7f · 7g
SP1: - - - - - - - - -
SP2: - - - - - - - - - - -
SP3: - - - - - - - -
SP4: - - -
SP5: - - - -
SP6: -
SP7: -
SP8: - -
SP9: - - - - - - -
SP10:

Relevant External Links for THAP7 Gene

GeneLoc Exon Structure for
THAP7
ECgene alternative splicing isoforms for
THAP7

Expression for THAP7 Gene

mRNA expression in normal human tissues for THAP7 Gene

Protein differential expression in normal tissues from HIPED for THAP7 Gene

This gene is overexpressed in Adipocyte (66.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for THAP7 Gene



SOURCE GeneReport for Unigene cluster for THAP7 Gene Hs.512756

genes like me logo Genes that share expression patterns with THAP7: view

Protein tissue co-expression partners for THAP7 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for THAP7 Gene

Orthologs for THAP7 Gene

This gene was present in the common ancestor of chordates.

Orthologs for THAP7 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia THAP7 35
  • 90.26 (n)
  • 97.4 (a)
THAP7 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia THAP7 35
  • 91.05 (n)
  • 96.76 (a)
THAP7 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Thap7 35
  • 89 (n)
  • 92.88 (a)
Thap7 16
Thap7 36
  • 93 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia THAP7 35
  • 99.35 (n)
  • 99.35 (a)
THAP7 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Thap7 35
  • 87.92 (n)
  • 91.91 (a)
chicken
(Gallus gallus)
Aves THAP7 35
  • 64.82 (n)
  • 64.82 (a)
THAP7 36
  • 53 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia THAP7 36
  • 60 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.10237 35
thap7 35
  • 56.66 (n)
  • 57.76 (a)
zebrafish
(Danio rerio)
Actinopterygii thap7 35
  • 48.91 (n)
  • 44.83 (a)
thap7 36
  • 21 (a)
OneToOne
Species with no ortholog for THAP7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for THAP7 Gene

ENSEMBL:
Gene Tree for THAP7 (if available)
TreeFam:
Gene Tree for THAP7 (if available)

Paralogs for THAP7 Gene

No data available for Paralogs for THAP7 Gene

Variants for THAP7 Gene

Sequence variations from dbSNP and Humsavar for THAP7 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
VAR_060277 -
rs12574 -- 20,999,869(+) TCAGT(C/G)CAGCA utr-variant-3-prime
rs3747084 -- 20,999,636(+) TCTGA(A/C/G)GGGTG downstream-variant-500B
rs374664770 -- 20,999,595(+) GCTGC(A/G)CTAGC downstream-variant-500B
rs375031070 -- 20,999,877(+) GCAGC(C/T)CCTCA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for THAP7 Gene

Variant ID Type Subtype PubMed ID
nsv436864 CNV Insertion 17901297
nsv914390 CNV Gain 21882294
nsv523162 CNV Loss 19592680
esv2678175 CNV Deletion 23128226
nsv914419 CNV Gain 21882294
nsv834141 CNV Loss 17160897
dgv4872n71 CNV Loss 21882294
nsv914423 CNV Gain 21882294
nsv828960 CNV Loss 20364138
dgv4873n71 CNV Loss 21882294
nsv471185 CNV Loss 18288195
nsv834142 CNV Gain 17160897
nsv828961 CNV Gain 20364138
nsv914428 CNV Loss 21882294
nsv482071 CNV Gain 20164927

Variation tolerance for THAP7 Gene

Residual Variation Intolerance Score: 37.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.83; 34.42% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for THAP7 Gene

Disorders for THAP7 Gene

Relevant External Links for THAP7

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
THAP7

No disorders were found for THAP7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for THAP7 Gene

Publications for THAP7 Gene

  1. Human THAP7 is a chromatin-associated, histone tail-binding protein that represses transcription via recruitment of HDAC3 and nuclear hormone receptor corepressor. (PMID: 15561719) Macfarlan T. … Chakravarti D. (J. Biol. Chem. 2005) 3 4 67
  2. Thanatos-associated protein 7 associates with template activating factor-Ibeta and inhibits histone acetylation to repress transcription. (PMID: 16195249) Macfarlan T. … Chakravarti D. (Mol. Endocrinol. 2006) 3 23
  3. The THAP domain: a novel protein motif with similarity to the DNA-binding domain of P element transposase. (PMID: 12575992) Roussigne M. … Girard J.P. (Trends Biochem. Sci. 2003) 2 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. The palmitoyl acyltransferase HIP14 shares a high proportion of interactors with huntingtin: implications for a role in the pathogenesis of Huntington's disease. (PMID: 24705354) Butland S.L. … Hayden M.R. (Hum. Mol. Genet. 2014) 3

Products for THAP7 Gene

Sources for THAP7 Gene

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