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Aliases for THAP7 Gene

Aliases for THAP7 Gene

  • THAP Domain Containing 7 2 3 5

External Ids for THAP7 Gene

Previous GeneCards Identifiers for THAP7 Gene

  • GC22M019678
  • GC22M021353
  • GC22M004622

Summaries for THAP7 Gene

GeneCards Summary for THAP7 Gene

THAP7 (THAP Domain Containing 7) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding and C2H2 zinc finger domain binding.

UniProtKB/Swiss-Prot for THAP7 Gene

  • Chromatin-associated, histone tail-binding protein that represses transcription via recruitment of HDAC3 and nuclear hormone receptor corepressors.

Gene Wiki entry for THAP7 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for THAP7 Gene

Genomics for THAP7 Gene

Regulatory Elements for THAP7 Gene

Enhancers for THAP7 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH22F020494 1.5 FANTOM5 ENCODE 35.7 +506.4 506353 2.7 CREB3L1 FEZF1 YBX1 SLC30A9 ZNF416 ZNF143 ZNF548 ZNF263 SP3 MEF2D DGCR8 RPL7AP70 LOC100420177 THAP7 THAP7-AS1 TUBA3GP RPL8P5 TBX1 TUBA3FP LOC105372938
GH22F020605 1.3 Ensembl ENCODE 33.5 +395.7 395656 1.7 HDGF ATF1 ZFP64 ARID4B SIN3A ZNF48 ZNF2 ZNF143 KLF13 MCM3 DGCR8 THAP7 LOC100420177 RPL7AP70 THAP7-AS1 PI4KA SCARF2 SERPIND1 TUBA3FP TBX1
GH22F020978 1.2 ENCODE 35.3 +20.6 20632 5.3 HDGF PKNOX1 ARNT CREB3L1 MLX ARID4B SIN3A FEZF1 DMAP1 ZNF2 THAP7-AS1 LOC100420177 THAP7 LZTR1 SCARF2 ENSG00000273342 ABHD17AP4 ENSG00000273343 DGCR8 PI4KA
GH22F021936 1.5 FANTOM5 ENCODE 27.6 -942.6 -942552 17.5 HDGF PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF143 ENSG00000224086 TOP3BP1 TOP3B IGLV5-52 THAP7 THAP7-AS1 ENSG00000234630 ENSG00000272779 PPM1F PPIL2
GH22F020548 1.7 FANTOM5 Ensembl ENCODE 24.2 +448.5 448507 11.0 HDGF PKNOX1 ARNT CREB3L1 MLX SIN3A ARID4B FEZF1 YBX1 YY1 THAP7-AS1 SCARF2 MED15 LOC100420177 THAP7 PI4KA LOC105372938 ABHD17AP4 KLHL22 DGCR8
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around THAP7 on UCSC Golden Path with GeneCards custom track

Promoters for THAP7 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000292002 -204 2801 HDGF PKNOX1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 SLC30A9

Genomic Location for THAP7 Gene

Chromosome:
22
Start:
20,999,104 bp from pter
End:
21,002,196 bp from pter
Size:
3,093 bases
Orientation:
Minus strand

Genomic View for THAP7 Gene

Genes around THAP7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
THAP7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for THAP7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for THAP7 Gene

Proteins for THAP7 Gene

  • Protein details for THAP7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BT49-THAP7_HUMAN
    Recommended name:
    THAP domain-containing protein 7
    Protein Accession:
    Q9BT49
    Secondary Accessions:
    • B2RD97
    • D3DX40

    Protein attributes for THAP7 Gene

    Size:
    309 amino acids
    Molecular mass:
    34414 Da
    Quaternary structure:
    • Interacts with HDAC3 and nuclear hormone receptor corepressors.

neXtProt entry for THAP7 Gene

Post-translational modifications for THAP7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for THAP7 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for THAP7 Gene

Domains & Families for THAP7 Gene

Gene Families for THAP7 Gene

Protein Domains for THAP7 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for THAP7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BT49

UniProtKB/Swiss-Prot:

THAP7_HUMAN :
  • Contains 1 THAP-type zinc finger.
Similarity:
  • Contains 1 THAP-type zinc finger.
genes like me logo Genes that share domains with THAP7: view

Function for THAP7 Gene

Molecular function for THAP7 Gene

UniProtKB/Swiss-Prot Function:
Chromatin-associated, histone tail-binding protein that represses transcription via recruitment of HDAC3 and nuclear hormone receptor corepressors.

Gene Ontology (GO) - Molecular Function for THAP7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 16189514
GO:0042802 identical protein binding IPI 25416956
GO:0046872 metal ion binding IEA --
GO:0047485 protein N-terminus binding IPI 17577209
genes like me logo Genes that share ontologies with THAP7: view
genes like me logo Genes that share phenotypes with THAP7: view

Animal Model Products

miRNA for THAP7 Gene

miRTarBase miRNAs that target THAP7

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for THAP7 Gene

Localization for THAP7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for THAP7 Gene

Nucleus. Chromosome.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for THAP7 gene
Compartment Confidence
nucleus 5
extracellular 2
peroxisome 1
cytosol 1

Gene Ontology (GO) - Cellular Components for THAP7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005694 chromosome IEA --
GO:0016607 nuclear speck IDA 17577209
genes like me logo Genes that share ontologies with THAP7: view

Pathways & Interactions for THAP7 Gene

SuperPathways for THAP7 Gene

No Data Available

Gene Ontology (GO) - Biological Process for THAP7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0045892 negative regulation of transcription, DNA-templated IDA 17577209
genes like me logo Genes that share ontologies with THAP7: view

No data available for Pathways by source and SIGNOR curated interactions for THAP7 Gene

Transcripts for THAP7 Gene

Unigene Clusters for THAP7 Gene

THAP domain containing 7:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for THAP7 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b · 3c · 3d · 3e ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b · 6c ^ 7a · 7b · 7c · 7d · 7e · 7f · 7g
SP1: - - - - - - - - -
SP2: - - - - - - - - - - -
SP3: - - - - - - - -
SP4: - - -
SP5: - - - -
SP6: -
SP7: -
SP8: - -
SP9: - - - - - - -
SP10:

Relevant External Links for THAP7 Gene

GeneLoc Exon Structure for
THAP7
ECgene alternative splicing isoforms for
THAP7

Expression for THAP7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for THAP7 Gene

Protein differential expression in normal tissues from HIPED for THAP7 Gene

This gene is overexpressed in Adipocyte (66.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for THAP7 Gene



Protein tissue co-expression partners for THAP7 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of THAP7 Gene:

THAP7

SOURCE GeneReport for Unigene cluster for THAP7 Gene:

Hs.512756
genes like me logo Genes that share expression patterns with THAP7: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for THAP7 Gene

Orthologs for THAP7 Gene

This gene was present in the common ancestor of chordates.

Orthologs for THAP7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia THAP7 34 35
  • 99.35 (n)
dog
(Canis familiaris)
Mammalia THAP7 34 35
  • 91.05 (n)
cow
(Bos Taurus)
Mammalia THAP7 34 35
  • 90.26 (n)
mouse
(Mus musculus)
Mammalia Thap7 34 16 35
  • 89 (n)
rat
(Rattus norvegicus)
Mammalia Thap7 34
  • 87.92 (n)
chicken
(Gallus gallus)
Aves THAP7 34 35
  • 64.82 (n)
lizard
(Anolis carolinensis)
Reptilia THAP7 35
  • 60 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia thap7 34
  • 56.66 (n)
Str.10237 34
zebrafish
(Danio rerio)
Actinopterygii thap7 34 35
  • 48.91 (n)
Species where no ortholog for THAP7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for THAP7 Gene

ENSEMBL:
Gene Tree for THAP7 (if available)
TreeFam:
Gene Tree for THAP7 (if available)

Paralogs for THAP7 Gene

No data available for Paralogs for THAP7 Gene

Variants for THAP7 Gene

Sequence variations from dbSNP and Humsavar for THAP7 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs1053775 -- 21,002,864(+) GAATA(C/T)AGAGG intron-variant, upstream-variant-2KB
rs1053777 -- 21,003,050(+) GGCCG(A/C)ACTTA intron-variant, nc-transcript-variant, upstream-variant-2KB
rs111960103 -- 21,003,615(+) CTCTG(C/T)CTCAG intron-variant, upstream-variant-2KB
rs112735480 -- 21,003,378(+) CTTCT(C/T)CTCCT intron-variant, upstream-variant-2KB
rs113800442 -- 21,002,261(+) CGCGT(C/T)GTCCC nc-transcript-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for THAP7 Gene

Variant ID Type Subtype PubMed ID
nsv834142 CNV gain 17160897
nsv834141 CNV loss 17160897
nsv828961 CNV gain 20364138
nsv828960 CNV loss 20364138
nsv588306 CNV gain 21841781
nsv588305 CNV loss 21841781
nsv523162 CNV loss 19592680
nsv482071 CNV gain 20164927
nsv471185 CNV loss 18288195
nsv436864 CNV insertion 17901297
nsv1065617 CNV gain 25217958
nsv1062280 CNV gain 25217958
nsv1056614 CNV loss 25217958
esv3893441 CNV gain+loss 25118596
esv3647305 CNV gain 21293372
esv3647304 CNV loss 21293372
esv2763693 CNV gain 21179565
esv2678175 CNV deletion 23128226
dgv7994n54 CNV gain 21841781
dgv7993n54 CNV gain 21841781
dgv4483n100 CNV gain 25217958

Variation tolerance for THAP7 Gene

Residual Variation Intolerance Score: 37.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.83; 34.42% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for THAP7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
THAP7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for THAP7 Gene

Disorders for THAP7 Gene

Relevant External Links for THAP7

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
THAP7

No disorders were found for THAP7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for THAP7 Gene

Publications for THAP7 Gene

  1. Thanatos-associated protein 7 associates with template activating factor-Ibeta and inhibits histone acetylation to repress transcription. (PMID: 16195249) Macfarlan T. … Chakravarti D. (Mol. Endocrinol. 2006) 3 22 64
  2. Human THAP7 is a chromatin-associated, histone tail-binding protein that represses transcription via recruitment of HDAC3 and nuclear hormone receptor corepressor. (PMID: 15561719) Macfarlan T. … Chakravarti D. (J. Biol. Chem. 2005) 3 4 64
  3. A genome annotation-driven approach to cloning the human ORFeome. (PMID: 15461802) Collins J.E. … Dunham I. (Genome Biol. 2004) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. The THAP domain: a novel protein motif with similarity to the DNA-binding domain of P element transposase. (PMID: 12575992) Roussigne M. … Girard J.P. (Trends Biochem. Sci. 2003) 2 3 64

Products for THAP7 Gene

Sources for THAP7 Gene

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