Aliases for THAP6 Gene
External Ids for THAP6 Gene
- HGNC: 23189
- Entrez Gene: 152815
- Ensembl: ENSG00000174796
- OMIM: 612535
- UniProtKB: Q8TBB0
Previous GeneCards Identifiers for THAP6 Gene
- GC04P076832
- GC04P076898
- GC04P076796
- GC04P076658
- GC04P076439
- GC04P072186
Summaries for THAP6 Gene
GeneCards Summary for THAP6 Gene
THAP6 (THAP Domain Containing 6) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is THAP9.
No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for THAP6 Gene
Genomics for THAP6 Gene
GeneHancer (GH) Regulatory Elements for THAP6 Gene
Promoters and enhancers for THAP6 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around THAP6 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for THAP6 Gene
Genomic Locations for THAP6 Gene
- chr4:75,509,860-75,550,473
- (GRCh38/hg38)
- Size:
- 40,614 bases
- Orientation:
- Plus strand
- chr4:76,439,156-76,475,683
- (GRCh37/hg19)
Genomic View for THAP6 Gene
Genes around THAP6 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 4q21.1 by Ensembl
- 4q21.1 by Entrez Gene
- 4q21.1 by HGNC
THAP6 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for THAP6 Gene
Proteins for THAP6 Gene
-
Protein details for THAP6 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q8TBB0-THAP6_HUMAN
- Recommended name:
- THAP domain-containing protein 6
- Protein Accession:
- Q8TBB0
- B4E146
- Q5HYJ7
- Q5JPC6
Protein attributes for THAP6 Gene
- Size:
- 222 amino acids
- Molecular mass:
- 25691 Da
- Quaternary structure:
- No Data Available
Protein Expression for THAP6 Gene
Post-translational modifications for THAP6 Gene
No Post-translational modifications
Other Protein References for THAP6 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for THAP6
- Invitrogen Antibodies for THAP6
- Search GeneTex for Antibodies for THAP6
Protein Products
-
OriGene Purified Proteins for THAP6
- Search Origene for MassSpec and Protein Over-expression Lysates for THAP6
- Origene Custom Protein Services for THAP6
- Search GeneTex for Proteins for THAP6
-
Abcam proteins for THAP6
Assay Products
No data available for DME Specific Peptides for THAP6 Gene
Domains & Families for THAP6 Gene
Gene Families for THAP6 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
- Transcription factors
Suggested Antigen Peptide Sequences for THAP6 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for THAP6 Gene
Function for THAP6 Gene
Phenotypes From GWAS Catalog for THAP6 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003677 | DNA binding | IEA | -- |
| GO:0005515 | protein binding | IPI | 25416956 |
| GO:0046872 | metal ion binding | IEA | -- |
Phenotypes for THAP6 Gene
- GenomeRNAi human phenotypes for THAP6:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for THAP6 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for THAP6 gene
- Search ViGene Biosciences for THAP6
CRISPR Products
-
OriGene CRISPR knockouts for THAP6
- genomics-online: gRNA clones - Search results for 62 available THAP6 gene related products
- Overview of 62 available THAP6 gene related products
- Applied Biological Materials CRISPR for THAP6
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for THAP6
- GenScript: Design CRISPR guide RNA sequences for THAP6
miRNA for THAP6 Gene
- miRTarBase miRNAs that target THAP6
-
- hsa-mir-106b-5p (MIRT020464)
- hsa-mir-943 (MIRT094189)
- hsa-mir-548t-5p (MIRT094192)
- hsa-mir-4318 (MIRT094193)
- hsa-mir-3609 (MIRT094194)
- hsa-mir-3688-5p (MIRT094195)
- hsa-mir-548ah-5p (MIRT094197)
- hsa-mir-548az-5p (MIRT094199)
- hsa-mir-3529-5p (MIRT694902)
- hsa-mir-599 (MIRT694903)
- hsa-mir-5089-5p (MIRT694904)
- hsa-mir-891a-3p (MIRT694905)
- hsa-mir-1290 (MIRT694906)
- hsa-mir-4771 (MIRT694907)
- hsa-mir-6506-5p (MIRT694908)
- hsa-mir-619-5p (MIRT694909)
- hsa-mir-4494 (MIRT694910)
- hsa-mir-3677-5p (MIRT694911)
- hsa-mir-4463 (MIRT694912)
- hsa-mir-548n (MIRT694913)
- hsa-mir-6805-3p (MIRT706910)
- hsa-mir-5691 (MIRT706911)
- hsa-mir-1178-3p (MIRT706912)
- hsa-mir-431-5p (MIRT706913)
- hsa-mir-3652 (MIRT706914)
- hsa-mir-4430 (MIRT706915)
- hsa-mir-122-5p (MIRT706916)
- hsa-mir-504-3p (MIRT706917)
- hsa-mir-3194-3p (MIRT706918)
- hsa-mir-3135b (MIRT706919)
- hsa-mir-3934-3p (MIRT706920)
- hsa-mir-891a-5p (MIRT706921)
- hsa-mir-367-5p (MIRT706922)
- hsa-mir-1267 (MIRT706923)
- hsa-mir-484 (MIRT706924)
- hsa-mir-3155b (MIRT706925)
- hsa-mir-3155a (MIRT706926)
- hsa-mir-454-3p (MIRT706927)
- hsa-mir-4295 (MIRT706928)
- hsa-mir-3666 (MIRT706929)
- hsa-mir-301b-3p (MIRT706930)
- hsa-mir-301a-3p (MIRT706931)
- hsa-mir-130b-3p (MIRT706932)
- hsa-mir-130a-3p (MIRT706933)
- hsa-mir-1247-3p (MIRT761576)
- hsa-mir-1281 (MIRT762154)
- hsa-mir-150-5p (MIRT762875)
- hsa-mir-1976 (MIRT763600)
- hsa-mir-2116-3p (MIRT763818)
- hsa-mir-3653-5p (MIRT766395)
- hsa-mir-4264 (MIRT768216)
- hsa-mir-4279 (MIRT768348)
- hsa-mir-4532 (MIRT770090)
- hsa-mir-4713-5p (MIRT771400)
- hsa-mir-4722-3p (MIRT771513)
- hsa-mir-498 (MIRT772865)
- hsa-mir-532-3p (MIRT773933)
- hsa-mir-5571-5p (MIRT774678)
- hsa-mir-562 (MIRT774906)
- hsa-mir-5697 (MIRT775126)
- hsa-mir-622 (MIRT776081)
- hsa-mir-6727-3p (MIRT777915)
- hsa-mir-6747-3p (MIRT778302)
- hsa-mir-6778-3p (MIRT778832)
- hsa-mir-6814-5p (MIRT779805)
miRNA Products
- Search ViGene Biosciences for THAP6
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for THAP6
- Browse OriGene Inhibitory RNA Products For THAP6
- genomics-online: shRNA clones - Search results for 62 available THAP6 gene related products
- Overview of 62 available THAP6 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for THAP6 gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Applied Biological Materials Clones for THAP6
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for THAP6
-
ViGene Biosciences adenoviral particle packaged cDNA for THAP6 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for THAP6 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for THAP6 gene
No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for THAP6 Gene
Localization for THAP6 Gene
| Compartment | Confidence |
|---|---|
| cytoskeleton | 5 |
| nucleus | 3 |
| extracellular | 1 |
| mitochondrion | 1 |
| cytosol | 1 |
- Centrosome (2)
- Nucleus (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0015630 | microtubule cytoskeleton | IDA | -- |
No data available for Subcellular locations from UniProtKB/Swiss-Prot for THAP6 Gene
Transcripts for THAP6 Gene
mRNA/cDNA for THAP6 Gene
- (9) REFSEQ mRNAs :
- (9) Additional mRNA sequences :
- (111) Selected AceView cDNA sequences:
- (13) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for THAP6 Gene
CRISPR Products
-
OriGene CRISPR knockouts for THAP6
- genomics-online: gRNA clones - Search results for 62 available THAP6 gene related products
- Overview of 62 available THAP6 gene related products
- Applied Biological Materials CRISPR for THAP6
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for THAP6
- GenScript: Design CRISPR guide RNA sequences for THAP6
miRNA Products
- Search ViGene Biosciences for THAP6
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for THAP6
- Browse OriGene Inhibitory RNA Products For THAP6
- genomics-online: shRNA clones - Search results for 62 available THAP6 gene related products
- Overview of 62 available THAP6 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for THAP6 gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Applied Biological Materials Clones for THAP6
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1 | ^ | 2a | · | 2b | · | 2c | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6a | · | 6b | ^ | 7a | · | 7b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | |||||||||||||||||||||
| SP2: | - | ||||||||||||||||||||||
| SP3: | - | - | - | ||||||||||||||||||||
| SP4: | |||||||||||||||||||||||
| SP5: | - | - | - | - | |||||||||||||||||||
| SP6: | - | - |
Expression for THAP6 Gene
This gene is overexpressed in Heart (57.5) and Monocytes (9.6).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for THAP6 Gene
NURSA nuclear receptor signaling pathways regulating expression of THAP6 Gene:
THAP6SOURCE GeneReport for Unigene cluster for THAP6 Gene:
Hs.479971Evidence on tissue expression from TISSUES for THAP6 Gene
- Heart(4.2)
- Nervous system(2)
Primer Products
-
OriGene qPCR primer pairs for THAP6
- genomics-online: primer clones - Search results for 62 available THAP6 gene related products
- Overview of 62 available THAP6 gene related products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for THAP6 Gene
Orthologs for THAP6 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | THAP6 33 34 |
|
||
| dog (Canis familiaris) |
Mammalia | THAP6 33 34 |
|
||
| cow (Bos Taurus) |
Mammalia | THAP6 33 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Thap6 33 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | THAP6 34 |
|
OneToOne | |
| zebrafish (Danio rerio) |
Actinopterygii | THAP6 (2 of 2) 34 |
|
OneToMany | |
| CU655961.1 34 |
|
OneToMany |
- Species where no ortholog for THAP6 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- mouse (Mus musculus)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for THAP6 Gene
(2) SIMAP similar genes for THAP6 Gene using alignment to 9 proteins:
Variants for THAP6 Gene
| SNP ID | Clin | Chr 04 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000407828 | -- | 75,517,460(+) | TTTT/TTT | intron_variant | |
| rs1000528743 | -- | 75,518,562(+) | T/G | intron_variant | |
| rs1000587755 | -- | 75,512,164(+) | T/G | upstream_transcript_variant | |
| rs1000595253 | -- | 75,517,190(+) | G/A | intron_variant | |
| rs1000632925 | -- | 75,523,686(+) | C/T | intron_variant |
Residual Variation Intolerance Score:
86.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
3.40;
54.27% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for THAP6 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- THAP6
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for THAP6 Gene
Disorders for THAP6 Gene
Additional Disease Information for THAP6
- Genetic Association Database
- (GAD)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No disorders were found for THAP6 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for THAP6 Gene
Publications for THAP6 Gene
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
- The THAP domain: a novel protein motif with similarity to the DNA-binding domain of P element transposase. (PMID: 12575992) Roussigne M … Girard JP (Trends in biochemical sciences 2003) 2 3 58
- A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 58
- Toward an understanding of the protein interaction network of the human liver. (PMID: 21988832) Wang J … Yang X (Molecular systems biology 2011) 3 58
Products for THAP6 Gene
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- Browse Primary Antibodies
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- Custom Antibody ServicesOriGene Antibodies for THAP6
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- Novus Biologicals
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- Cloud-Clone Corp. disease models service
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- Cloud-Clone Corp. primary cells service
- Invitrogen Antibodies for THAP6
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- antibodies-online: Search results for available THAP6 related products ranked by validation data
- antibodies-online: Search results for available THAP6 related products ranked by validation data
- antibodies-online: Search results for available THAP6 related products ranked by validation data
- Search GeneTex for Antibodies for THAP6
- Search GeneTex for Proteins for THAP6
- ViGene Biosciences adenoviral particle packaged cDNA for THAP6 gene
- ViGene Biosciences lentiviral particle packaged cDNA for THAP6 gene
- ViGene Biosciences ready-to-package AAV shRNAs for THAP6 gene
- Search ViGene Biosciences for THAP6
- Horizon Cell Lines for THAP6
- genomics-online: cdna clones - Search results for 62 available THAP6 gene related products
- Overview of 62 available THAP6 gene related products
- orf clones - Search results for 62 available THAP6 gene related products
- Overview of 62 available THAP6 gene related products
- genomics-online: gRNA clones - Search results for 62 available THAP6 gene related products
- Overview of 62 available THAP6 gene related products
- genomics-online: primer clones - Search results for 62 available THAP6 gene related products
- Overview of 62 available THAP6 gene related products
- genomics-online: shRNA clones - Search results for 62 available THAP6 gene related products
- Overview of 62 available THAP6 gene related products
Sources for THAP6 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew