THAP6 Gene
protein-coding GIFtS: 46
GCID: GC04P076439
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THAP Domain Containing 6
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Aliases
for THAP6 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
10fRNAdb,
12H-InvDB,
13NCBI,
14NONCODE,
and/or 15RNAdb)
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| Aliases |
|---|
| THAP Domain Containing 61 2 | | THAP Domain-Containing Protein 62 |
Export aliases for THAP6 gene to outside databasesPrevious GC identifers: GC04P076832 GC04P076898 GC04P076796 GC04P076658 GC04P072186 |
Summaries
for THAP6 gene(According to Entrez Gene,
GeneCards,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
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GeneCards Summary for THAP6 Gene:
THAP6 (THAP domain containing 6) is a protein-coding gene. An important paralog of this gene is THAP9.
Gene Wiki entry for THAP6 Gene
|
Genomic Views
for THAP6 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 75),
Regulatory elements and Epigenetics data according to
QIAGEN, and/or
SwitchGear Genomics)
About This Section
TryGeneCards Plus | RefSeq DNA sequence:- NC_000004.12 NT_016354.20 NC_018915.2
Regulatory elements:
 Regulatory transcription factor binding sites in the THAP6 gene promoter:
NF-1 NF-1/L LCR-F1
Other transcription factors
Search Chromatin IP Primers for THAP6
Epigenetics:
| | DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat THAP6 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 4q21.1 Ensembl cytogenetic band: 4q21.1 HGNC cytogenetic band: 4q21.21THAP6 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 4 GeneLoc Exon Structure GeneLoc location for GC04P076439: view genomic region
(about GC identifiers)
Start:
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76,439,156 bp from pter |
End:
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76,475,683 bp from pter |
Size:
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36,528 bases |
Orientation:
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plus strand |
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Proteins
for THAP6 gene
(According to
1UniProtKB,
HORDE,
2neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to PhosphoSitePlus,
Specific Peptides from DME,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Cloud-Clone Corp.,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Cloud-Clone Corp.,
Antibodies by
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
LSBio,
Abcam, and/or
Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: THAP6_HUMAN, Q8TBB0 (See
protein sequence)Recommended Name: THAP domain-containing protein 6 Size: 222 amino acids; 25691 Da
Secondary accessions: Q5HYJ7 Q5JPC6Alternative splicing: 2 isoforms: Q8TBB0-1 Q8TBB0-2 Explore the universe of human proteins at neXtProt for THAP6: NX_Q8TBB0
Explore proteomics data for THAP6 at MOPED
See THAP6 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB
REFSEQ proteins: NP_653322.1
ENSEMBL proteins: ENSP00000422402 ENSP00000425646 ENSP00000424949 ENSP00000426760 ENSP00000309007 ENSP00000370217 ENSP00000427651 ENSP00000426581 ENSP00000424255 ENSP00000426698 ENSP00000423720
THAP6 Human Recombinant
Protein Products:THAP6 Antibody
Products:THAP6 Assay Products: |
Domains /
Families
for THAP6 gene(According to HGNC, IUPHAR, InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
TryGeneCards Plus | HGNC Gene Families:
THAP: THAP (C2CH-type zinc finger) domain containing
2 InterPro protein domains:Graphical View of Domain Structure for InterPro Entry Q8TBB0ProtoNet protein and cluster: Q8TBB0 UniProtKB/Swiss-Prot: THAP6_HUMAN, Q8TBB0Similarity: Contains 1 THAP-type zinc finger
THAP6 for domains About GeneDecksing
|
Function
for THAP6 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
genOway,
transcription factor targeting from QIAGEN
and/or HOMER,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
SwitchGear Genomics,
Gene Editing from DNA2.0,
Clones from OriGene,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
ESI BIO,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Apr 2014 via
Entrez Gene.)
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Gene Ontology (GO): 3 molecular function terms: About this table
THAP6 for ontologies About GeneDecksing
Phenotypes:
1 GenomeRNAi human phenotype for THAP6:
Animal Models:
Inhib. RNA
Products: |  | OriGene RNAi products in human, mouse, rat for THAP6
| | | Predesigned siRNA for gene silencing in human, mouse, rat THAP6 |
Cell Line
Products: |  | GenScript Custom overexpressing Cell Line Services for THAP6 | |  | Browse ESI BIO Cell Lines and PureStem Progenitors for THAP6  | In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for THAP6 |
Localization
for THAP6 gene
(According to UniProtKB, COMPARTMENTS Subcellular localization database,
Ontologies according to Gene Ontology Consortium 01 Apr 2014 via
Entrez Gene.)
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Subcellular locations from COMPARTMENTS:
| Compartment | Confidence |
|---|
|
| cytoskeleton | 4 | | nucleus | 2 | | cytosol | 1 | | extracellular | 1 | | mitochondrion | 1 |
Gene Ontology (GO): 1 cellular component term: About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0015630 | microtubule cytoskeleton |
IDA | -- |
THAP6 for ontologies About GeneDecksing
|
Pathways & Interactions
for THAP6 gene
(SuperPaths according to PathCards,
Pathways according to
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Sino Biological,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
QIAGEN,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2014 via
Entrez Gene).
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Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for THAP6
Interactions:
Search GeneGlobe Interaction Network for THAP6
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
1 Interacting protein for THAP6 (ENSP000003090074) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for THAP6 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience,
ApexBio,
HMDB,
BitterDB, and/or
Novoseek,
Ligands according to IUPHAR,
and Drugs according to DrugBank,
Enzo Life Sciences, and/or
PharmGKB)
About This Section
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 Browse compounds at ApexBio
 Browse Tocris compounds for THAP6
|
Transcripts
for THAP6 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
Conferences by KenesGroup,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
SwitchGear Genomics,
Tagged/untagged cDNA clones from
OriGene,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene, and/or
QIAGEN
)
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REFSEQ mRNAs for THAP6 gene: NM_144721.4 Unigene Cluster for THAP6: THAP domain containing 6 Hs.479971 [show with all ESTs]Unigene Representative Sequence: AL83335013 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000506261 ENST00000504218 ENST00000504384 ENST00000507557 ENST00000508105(uc010iis.1)
ENST00000311638(uc003him.3 uc010iiv.3) ENST00000380837(uc003hin.3)
ENST00000507556(uc011cbm.2) ENST00000504190 ENST00000507885(uc010iiu.1 uc003hio.1)
ENST00000502620 ENST00000503831 ENST00000514480
Inhib. RNA
Products: | | OriGene RNAi products in human, mouse, rat for THAP6
| |
| | Predesigned siRNA for gene silencing in human, mouse, rat THAP6 |
Primer
Products: | | OriGene qSTAR qPCR primer pairs in human, mouse for THAP6
| | | Pre-validated RT2 qPCR Primer Assay in human, mouse / rat THAP6 | | | QuantiTect SYBR Green Assays in human, mouse, rat THAP6 | | | QuantiFast Probe-based Assays in human, mouse, rat THAP6 |
Additional mRNA sequence: AK056959.1 AK303658.1 AK308914.1 AK309187.1 AK310575.1 AK313765.1 AL833350.1 BC022989.2 BX647579.1 9 DOTS entries: DT.97826213 DT.40279395 DT.95262753 DT.70104960 DT.75159976 DT.100774661 DT.121262247 DT.97805625 DT.121262260 Selected AceView cDNA sequences (see all 111): AI692280 C16675 AI743405 AI149757 AA625663 AW514141 AI863288 BE048145 CA844235 AW303925 NM_144721 BX441095 BC022989 AI445613 AI299820 AI199523 AW511818 AI701582 AA551198 AL833350 AI243354 AW135173 BG055369 BX111715
GeneLoc Exon Structure
Selected Alternative Splicing Database (ASD) splice patterns (SP) for THAP6 (see all 6) About this scheme
| ExUns: | 1 | ^ | 2a | · | 2b | · | 2c | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6a | · | 6b | ^ | 7a | · | 7b |
|---|
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| SP1: | | | | | | | | | - | | | | | | | | | | - | | | | | | |
| SP2: | | | | | | | | | - | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | - | | | | | | | | - | | - | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | - | | - | | - | | - | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for THAP6
|
Expression
for THAP6 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
Protein expression images according to data from SPIRE 1MOPED,
2PaxDb, and 3MaxQB,
plus additional links to
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
QIAGEN,
Primers from
OriGene, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
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THAP6 expression in normal human tissues
(normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: CCTTTCACAA
About this image THAP6 Protein expression data from MOPED1, PaxDb2 and
MaxQB3:  About this image
SOURCE GeneReport for Unigene cluster: Hs.479971
Custom PCR Arrays for THAP6
Primer
Products: | | OriGene qSTAR qPCR primer pairs in human, mouse for THAP6
| | | Pre-validated RT2 qPCR Primer Assay in human, mouse / rat THAP6 | | | QuantiTect SYBR Green Assays in human, mouse, rat THAP6 | | | QuantiFast Probe-based Assays in human, mouse, rat THAP6 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for THAP6 |
Orthologs
for THAP6 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
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This gene was present in the common ancestor of chordates.
Orthologs for THAP6 gene from Selected species (see all 6) About this table
ENSEMBL Gene Tree for THAP6 (if available)
TreeFam Gene Tree for THAP6 (if available) |
Paralogs
for THAP6 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
TryGeneCards Plus | Paralogs for THAP6 gene
- THAP92
2 SIMAP similar genes for THAP6 using alignment to 9 protein entries: THAP6_HUMAN (see all proteins):THAP9 THAP3
THAP6 for paralogs About GeneDecksing
|
Genomic Variants
for THAP6 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
4UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD), the Human Cytochrome P450 Allele
Nomenclature Database, and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
About This Section
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| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 4 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for THAP6 (76439156 - 76475683 bp)
Structural Variations
Database of Genomic Variants (DGV) 1 variation for THAP6: About this table
| | Site Specific Mutation Identification with PCR Assays |
| | SeqTarget long-range PCR primers for resequencing THAP6 |
|
Disorders
/ Diseases
for THAP6 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Conferences by KenesGroup,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
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OMIM gene information: 612535
OMIM disorders: --
THAP6 for disorders About GeneDecksing
Genetic Association Database (GAD): THAP6
Export disorders for THAP6 gene to outside databases
|
Publications
for THAP6 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
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PubMed articles for THAP6 gene, integrated from 10 sources (see all 12):
(articles sorted by number of sources associating them with THAP6) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
- The THAP domain: a novel protein motif with similarity to the DNA-binding domain of P element transposase. (PubMed id 12575992)1, 3 Roussigne M....Girard J.P. (Trends Biochem. Sci. 2003)
- Toward an understanding of the protein interaction network of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (Mol. Syst. Biol. 2011)
- The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (BMC Genomics 2007)
- The LIFEdb database in 2006. (PubMed id 16381901)1 Mehrle A....Wiemann S. (Nucleic Acids Res. 2006)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
- From ORFeome to biology: a functional genomics pipeline. (PubMed id 15489336)1 Wiemann S....Poustka A. (Genome Res. 2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
- Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1 Wiemann S.... Poustka A. (Genome Res. 2001)
|
External Searches for THAP6 gene (in PubMed,
OMIM, and NCBI Bookshelf)
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Genome Databases showing THAP6 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
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|
Other Databases showing THAP6 gene
(According to HUGE)
About This Section
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Specialized Databases showing THAP6 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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| Name | Description |
| PharmGKB entry for THAP6 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
TryGeneCards Plus | Patent Information for THAP6 gene:
Search GeneIP for patents involving THAP6
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for THAP6 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or
ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory,
genOway)
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 | |
 |
| | | | |
 |
 |
|  | Block miRNA regulation of human, mouse, rat THAP6 using miScript Target Protectors | | SeqTarget long-range PCR primers for resequencing THAP6 | | | DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat THAP6 | | Predesigned siRNA for gene silencing in human, mouse, rat THAP6 | | | QuantiFast Probe-based Assays in human, mouse, rat THAP6 | | QuantiTect SYBR Green Assays in human, mouse, rat THAP6 | | | Custom PCR Arrays for THAP6 | | Search Chromatin IP Primers for THAP6 | | | Pre-validated RT2 qPCR Primer Assay in human, mouse / rat THAP6 | | Search GeneGlobe Interaction Network for THAP6 | | | Regulatory tfbs in THAP6 promoter |
| |
 |  |  |  | |
| | | Search Tocris compounds for THAP6 |
| | |  |  |  |
 | | | | |
 |
 |
 |  | | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for THAP6 |
| |  |  |  |  | | | ThermoFisher Antibody for THAP6 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat THAP6 |
| | | | LSBio Antibodies in human, mouse, rat for THAP6 |
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