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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

THAP6 Gene

protein-coding   GIFtS: 46
GCID: GC04P076439

THAP domain containing 6
  Search for THAP6
in
MalaCards
our new
 Human Malady Compendium 
Biological research products
for THAP6    

Aliases
for THAP6 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
THAP Domain Containing 61 2
MGC300521
THAP Domain-Containing Protein 62

External Ids:    HGNC: 231891   Entrez Gene: 1528152   Ensembl: ENSG000001747967   OMIM: 6125355   UniProtKB: Q8TBB03   

Export aliases for THAP6 gene to outside databases

Previous GC identifers: GC04P076832 GC04P076898 GC04P076796 GC04P076658 GC04P072186


Summaries
for THAP6 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Gene Wiki entry for THAP6


Genomic Views
for THAP6 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NC_018915.1  NT_016354.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the THAP6 gene promoter:
         NF-1   NF-1/L   LCR-F1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: THAP6 promoter sequence
   Search SABiosciences Chromatin IP Primers for THAP6

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat THAP6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q21.1   Ensembl cytogenetic band:  4q21.1   HGNC cytogenetic band: 4q21.21

THAP6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
THAP6 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P076439:  view genomic region     (about GC identifiers)

Start:
 76,439,156 bp from pter      End:
 76,475,683 bp from pter
Size:
 36,528 bases      Orientation:
 plus strand

Proteins
for THAP6 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: THAP6_HUMAN, Q8TBB0 (See protein sequence)
Recommended Name: THAP domain-containing protein 6  
Size: 222 amino acids; 25691 Da
Secondary accessions: Q5HYJ7 Q5JPC6
Alternative splicing: 2 isoforms:  Q8TBB0-1   Q8TBB0-2   

Explore the universe of human proteins at neXtProt for THAP6: NX_Q8TBB0

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q8TBB0

    • THAP6 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_653322.1  
    ENSEMBL proteins: 
     ENSP00000422402   ENSP00000425646   ENSP00000424949   ENSP00000309007   ENSP00000370217  
     ENSP00000426760   ENSP00000426581   ENSP00000427651   ENSP00000424255   ENSP00000426698  
     ENSP00000423720  

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    Browse ProSpec Recombinant Proteins
    Uscn Proteins for THAP6

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0015630microtubule cytoskeleton IDA--


    THAP6 for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for THAP6 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    THAP6 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR026517 THAP6
     IPR006612 Znf_C2CH

    Graphical View of Domain Structure for InterPro Entry Q8TBB0

    ProtoNet protein and cluster: Q8TBB0

    UniProtKB/Swiss-Prot: THAP6_HUMAN, Q8TBB0
    Similarity: Contains 1 THAP-type zinc finger


    Function
    for THAP6 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    miRNA
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    8/25 QIAGEN miScript miRNA Assays for microRNAs that regulate THAP6 (see all 25):
    hsa-miR-607 hsa-miR-126 hsa-miR-16-2* hsa-miR-631 hsa-miR-513c hsa-miR-944 hsa-miR-3661 hsa-miR-890
    SwitchGear 3'UTR luciferase reporter plasmid: THAP6 3' UTR sequence
    Inhib. RNA
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    In Situ Assay
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    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0046872metal ion binding IEA--


    THAP6 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for THAP6:
     Low eccentricity cells 


    Pathways & Interactions
    for THAP6 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for THAP6

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for THAP6 (ENSP000003090074) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SDCBP2ENSP000003429354STRING: ENSP00000342935
    About this table

    Drugs & Compounds
    for THAP6 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for THAP6
    Search CenterWatch for drugs/clinical trials and news about THAP6 

    Transcripts
    for THAP6 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    About This Section
    REFSEQ mRNAs for THAP6 gene: 
    NM_144721.4  

    Unigene Cluster for THAP6:

    THAP domain containing 6
    Hs.479971  [show with all ESTs]
    Unigene Representative Sequence: AL833350
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000506261 ENST00000504218 ENST00000504384 ENST00000507557 ENST00000311638(uc003him.3 uc010iiv.3)
    ENST00000380837(uc003hin.3) ENST00000508105(uc010iis.1) ENST00000504190
    ENST00000507556(uc011cbm.2) ENST00000507885(uc010iiu.1 uc003hio.1)
    ENST00000502620 ENST00000503831 ENST00000514480

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    8/25 QIAGEN miScript miRNA Assays for microRNAs that regulate THAP6 (see all 25):
    hsa-miR-607 hsa-miR-126 hsa-miR-16-2* hsa-miR-631 hsa-miR-513c hsa-miR-944 hsa-miR-3661 hsa-miR-890
    SwitchGear 3'UTR luciferase reporter plasmid: THAP6 3' UTR sequence
    Inhib. RNA
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    OriGene siRNA: THAP6
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    Clone
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    Additional cDNA sequence: 

    AK056959.1 AK303658.1 AK308914.1 AK309187.1 AK310575.1 AK313765.1 AL833350.1 BC022989.2 
    BX647579.1 

    9 DOTS entries:

    DT.97826213  DT.40279395  DT.95262753  DT.70104960  DT.75159976  DT.100774661  DT.121262247  DT.97805625 
    DT.121262260 

    24/111 AceView cDNA sequences (see all 111):

    AW303925 AI299820 AI743405 AA551198 AI149757 AA625663 AI445613 AW514141 
    AI199523 C16675 NM_144721 CA844235 AI701582 AI863288 BE048145 AI692280 
    AL833350 AW511818 BX441095 BC022989 AI040531 AI342528 AW058657 BF685892 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for THAP6 (see all 6)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b
    SP1:                          -                             -               
    SP2:                          -                                             
    SP3:                          -                       -     -               
    SP4:                                                                        
    SP5:        -     -     -     -                                             


    ECgene alternative splicing isoforms for THAP6

    Expression
    for THAP6 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    THAP6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CCTTTCACAA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    THAP6 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    BoneMandibular ProcessBone
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See THAP6 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for THAP6

    SOURCE GeneReport for Unigene cluster: Hs.479971
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    In Situ
    Assay Products:     
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    Orthologs
    for THAP6 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for THAP6 gene from 2/7 species (see all 7)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Thap65 THAP domain containing 6   --   5 (45.62 cM) 91962882 
    zebrafish
    (Danio rerio)    		 Actinopterygii LOC1005351211 THAP domain-containing protein 6-like 49.18(n)
    38.8(a)    		   100535121  XM_003200095.1  XP_003200143.1 


    ENSEMBL Gene Tree for THAP6 (if available)
    TreeFam Gene Tree for THAP6 (if available) 

    Paralogs
    for THAP6 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for THAP6 gene
    THAP72  THAP92  
    2 SIMAP similar genes for THAP6 using alignment to 9 protein entries:     THAP6_HUMAN (see all proteins):
    THAP9    THAP3

    THAP6 for paralogs           About GeneDecksing



    Genomic Variants
    for THAP6 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section
    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing THAP6
    DNA2.0 Custom Variant and Variant Library Synthesis for THAP6

    Disorders / Diseases
    for THAP6 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    THAP6 for disorders           About MalaCards

    THAP6 for disorders           About GeneDecksing

    OMIM gene information: 612535    OMIM disorders: --


    Export disorders for THAP6 gene to outside databases

    Publications
    for THAP6 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for THAP6 gene, integrated from 9 sources (see all 11):
    (articles sorted by number of sources associating them with THAP6)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    3. The THAP domain: a novel protein motif with similarity to the DNA-binding domain of P element transposase. (PubMed id 12575992)1, 3 Roussigne M....Girard J.P. (2003)
    4. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
    5. The LIFEdb database in 2006. (PubMed id 16381901)1 Mehrle A....Wiemann S. (2006)
    6. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
    7. From ORFeome to biology: a functional genomics pipeline. (PubMed id 15489336)1 Wiemann S....Poustka A. (2004)
    8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    9. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1 Wiemann S.... Poustka A. (2001)
    10. Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing. (PubMed id 11256614)1 Simpson J.C.... Wiemann S. (2000)

    External Searches for THAP6 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing THAP6 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 152815 HGNC: 23189 AceView: THAP6 Ensembl:ENSG00000174796 euGenes: HUgn152815
    ECgene: THAP6 H-InvDB: THAP6

    Other Databases showing THAP6 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing THAP6 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for THAP6 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for THAP6 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for THAP6 gene:
    Search GeneIP for patents involving THAP6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for THAP6 gene

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    Advanced Cell Diagnostics
    About This Section

     
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