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Aliases for THAP6 Gene

Aliases for THAP6 Gene

  • THAP Domain Containing 6 2 3 5

External Ids for THAP6 Gene

Previous GeneCards Identifiers for THAP6 Gene

  • GC04P076832
  • GC04P076898
  • GC04P076796
  • GC04P076658
  • GC04P076439
  • GC04P072186

Summaries for THAP6 Gene

GeneCards Summary for THAP6 Gene

THAP6 (THAP Domain Containing 6) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is THAP9.

Gene Wiki entry for THAP6 Gene

Additional gene information for THAP6 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for THAP6 Gene

Genomics for THAP6 Gene

GeneHancer (GH) Regulatory Elements for THAP6 Gene

Promoters and enhancers for THAP6 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04I075511 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 570.2 +4.0 3961 4.9 HDGF PKNOX1 CLOCK FOXA2 SMAD1 MLX ARNT ZFP64 ARID4B SIN3A THAP6 RCHY1 NUP54
GH04I076146 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 23.9 +638.3 638311 2.5 FEZF1 DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF416 ZNF143 ZNF548 SP3 NUP54 GC04P076146 THAP6 ART3 RPL7P17 SDAD1
GH04I076205 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 16 +700.9 700934 10.3 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A DMAP1 ZNF2 IRF4 YY1 FAM47E SCARB2 GC04P076210 NUP54 THAP6 SDAD1 ART3 NAAA G3BP2 STBD1
GH04I074531 Enhancer 1.3 Ensembl ENCODE dbSUPER 16 -977.7 -977722 1.3 HDAC1 PKNOX1 ARNT NFRKB FEZF1 RAD21 ZBTB40 SCRT2 ZNF143 ATF7 THAP6 ENSG00000249942 AREG
GH04I076192 Enhancer 1.5 Ensembl ENCODE dbSUPER 9.7 +687.9 687933 9.7 HDGF PKNOX1 FOXA2 SMAD1 MLX ARID4B FEZF1 YBX1 ZNF2 IRF4 NUP54 SCARB2 RCHY1 THAP6 ART3 NAAA GC04P076210
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around THAP6 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the THAP6 gene promoter:

Genomic Locations for THAP6 Gene

Genomic Locations for THAP6 Gene
chr4:75,509,860-75,550,473
(GRCh38/hg38)
Size:
40,614 bases
Orientation:
Plus strand
chr4:76,439,156-76,475,683
(GRCh37/hg19)

Genomic View for THAP6 Gene

Genes around THAP6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
THAP6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for THAP6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for THAP6 Gene

Proteins for THAP6 Gene

  • Protein details for THAP6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TBB0-THAP6_HUMAN
    Recommended name:
    THAP domain-containing protein 6
    Protein Accession:
    Q8TBB0
    Secondary Accessions:
    • B4E146
    • Q5HYJ7
    • Q5JPC6

    Protein attributes for THAP6 Gene

    Size:
    222 amino acids
    Molecular mass:
    25691 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for THAP6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for THAP6 Gene

Post-translational modifications for THAP6 Gene

No Post-translational modifications

No data available for DME Specific Peptides for THAP6 Gene

Domains & Families for THAP6 Gene

Gene Families for THAP6 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for THAP6 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for THAP6 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with THAP6: view

No data available for UniProtKB/Swiss-Prot for THAP6 Gene

Function for THAP6 Gene

Phenotypes From GWAS Catalog for THAP6 Gene

Gene Ontology (GO) - Molecular Function for THAP6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 25416956
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with THAP6: view

Phenotypes for THAP6 Gene

genes like me logo Genes that share phenotypes with THAP6: view

miRNA for THAP6 Gene

miRTarBase miRNAs that target THAP6

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for THAP6 Gene

Localization for THAP6 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for THAP6 gene
Compartment Confidence
cytoskeleton 5
nucleus 3
extracellular 1
mitochondrion 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Centrosome (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for THAP6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015630 microtubule cytoskeleton IDA --
genes like me logo Genes that share ontologies with THAP6: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for THAP6 Gene

Pathways & Interactions for THAP6 Gene

SuperPathways for THAP6 Gene

No Data Available

Interacting Proteins for THAP6 Gene

Gene Ontology (GO) - Biological Process for THAP6 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for THAP6 Gene

Drugs & Compounds for THAP6 Gene

No Compound Related Data Available

Transcripts for THAP6 Gene

Unigene Clusters for THAP6 Gene

THAP domain containing 6:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for THAP6 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b
SP1: - -
SP2: -
SP3: - - -
SP4:
SP5: - - - -
SP6: - -

Relevant External Links for THAP6 Gene

GeneLoc Exon Structure for
THAP6
ECgene alternative splicing isoforms for
THAP6

Expression for THAP6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for THAP6 Gene

Protein differential expression in normal tissues from HIPED for THAP6 Gene

This gene is overexpressed in Heart (57.5) and Monocytes (9.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for THAP6 Gene



Protein tissue co-expression partners for THAP6 Gene

NURSA nuclear receptor signaling pathways regulating expression of THAP6 Gene:

THAP6

SOURCE GeneReport for Unigene cluster for THAP6 Gene:

Hs.479971

Evidence on tissue expression from TISSUES for THAP6 Gene

  • Heart(4.2)
  • Nervous system(2)
genes like me logo Genes that share expression patterns with THAP6: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for THAP6 Gene

Orthologs for THAP6 Gene

This gene was present in the common ancestor of chordates.

Orthologs for THAP6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia THAP6 33 34
  • 99.85 (n)
dog
(Canis familiaris)
Mammalia THAP6 33 34
  • 92.49 (n)
cow
(Bos Taurus)
Mammalia THAP6 33 34
  • 92.22 (n)
rat
(Rattus norvegicus)
Mammalia Thap6 33
  • 89.41 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia THAP6 34
  • 59 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii THAP6 (2 of 2) 34
  • 23 (a)
OneToMany
CU655961.1 34
  • 19 (a)
OneToMany
Species where no ortholog for THAP6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for THAP6 Gene

ENSEMBL:
Gene Tree for THAP6 (if available)
TreeFam:
Gene Tree for THAP6 (if available)

Paralogs for THAP6 Gene

Paralogs for THAP6 Gene

(2) SIMAP similar genes for THAP6 Gene using alignment to 9 proteins:

genes like me logo Genes that share paralogs with THAP6: view

Variants for THAP6 Gene

Sequence variations from dbSNP and Humsavar for THAP6 Gene

SNP ID Clin Chr 04 pos Variation AA Info Type
rs1000407828 -- 75,517,460(+) TTTT/TTT intron_variant
rs1000528743 -- 75,518,562(+) T/G intron_variant
rs1000587755 -- 75,512,164(+) T/G upstream_transcript_variant
rs1000595253 -- 75,517,190(+) G/A intron_variant
rs1000632925 -- 75,523,686(+) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for THAP6 Gene

Variant ID Type Subtype PubMed ID
esv3601031 CNV loss 21293372
nsv594687 CNV loss 21841781
nsv7363 OTHER inversion 18451855

Variation tolerance for THAP6 Gene

Residual Variation Intolerance Score: 86.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.40; 54.27% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for THAP6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
THAP6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for THAP6 Gene

Disorders for THAP6 Gene

Additional Disease Information for THAP6

No disorders were found for THAP6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for THAP6 Gene

Publications for THAP6 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. The THAP domain: a novel protein motif with similarity to the DNA-binding domain of P element transposase. (PMID: 12575992) Roussigne M … Girard JP (Trends in biochemical sciences 2003) 2 3 58
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 58
  5. Toward an understanding of the protein interaction network of the human liver. (PMID: 21988832) Wang J … Yang X (Molecular systems biology 2011) 3 58

Products for THAP6 Gene

Sources for THAP6 Gene

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