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THAP6 Gene

protein-coding   GIFtS: 46
GCID: GC04P076439

THAP Domain Containing 6

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
THAP Domain Containing 61 2
THAP Domain-Containing Protein 62

External Ids:    HGNC: 231891   Entrez Gene: 1528152   Ensembl: ENSG000001747967   OMIM: 6125355   UniProtKB: Q8TBB03   

Export aliases for THAP6 gene to outside databases

Previous GC identifers: GC04P076832 GC04P076898 GC04P076796 GC04P076658 GC04P072186


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for THAP6 Gene:
THAP6 (THAP domain containing 6) is a protein-coding gene. An important paralog of this gene is THAP9.

Gene Wiki entry for THAP6 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000004.11  NT_016354.20  NC_018915.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the THAP6 gene promoter:
         NF-1   NF-1/L   LCR-F1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTHAP6 promoter sequence
   Search Chromatin IP Primers for THAP6

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat THAP6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q21.1   Ensembl cytogenetic band:  4q21.1   HGNC cytogenetic band: 4q21.21

THAP6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
THAP6 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P076439:  view genomic region     (about GC identifiers)

Start:
76,439,156 bp from pter      End:
76,475,683 bp from pter
Size:
36,528 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: THAP6_HUMAN, Q8TBB0 (See protein sequence)
Recommended Name: THAP domain-containing protein 6  
Size: 222 amino acids; 25691 Da
Secondary accessions: Q5HYJ7 Q5JPC6
Alternative splicing: 2 isoforms:  Q8TBB0-1   Q8TBB0-2   

Explore the universe of human proteins at neXtProt for THAP6: NX_Q8TBB0

Explore proteomics data for THAP6 at MOPED


See THAP6 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_653322.1  
ENSEMBL proteins: 
 ENSP00000422402   ENSP00000425646   ENSP00000424949   ENSP00000426760   ENSP00000309007  
 ENSP00000370217   ENSP00000427651   ENSP00000426581   ENSP00000424255   ENSP00000426698  
 ENSP00000423720  

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
THAP: THAP (C2CH-type zinc finger) domain containing

2 InterPro protein domains:
 IPR026517 THAP6
 IPR006612 Znf_C2CH

Graphical View of Domain Structure for InterPro Entry Q8TBB0

ProtoNet protein and cluster: Q8TBB0

UniProtKB/Swiss-Prot: THAP6_HUMAN, Q8TBB0
Similarity: Contains 1 THAP-type zinc finger


Find genes that share domains with THAP6           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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     Gene Ontology (GO): 3 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0003676nucleic acid binding ----
GO:0003677DNA binding IEA--
GO:0046872metal ion binding IEA--
     
Find genes that share ontologies with THAP6           About GenesLikeMe


Phenotypes:
     1 GenomeRNAi human phenotype for THAP6:
 Low eccentricity cells 

Animal Models:
   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for THAP6
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miRNA
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miRTarBase miRNAs that target THAP6:
hsa-mir-106b-5p (MIRT020464)

Block miRNA regulation of human, mouse, rat THAP6 using miScript Target Protectors
Selected qRT-PCR Assays for microRNAs that regulate THAP6 (see all 25):
hsa-miR-607 hsa-miR-126 hsa-miR-16-2* hsa-miR-631 hsa-miR-513c hsa-miR-944 hsa-miR-3661 hsa-miR-890
SwitchGear 3'UTR luciferase reporter plasmidTHAP6 3' UTR sequence
Inhib. RNA
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Predesigned siRNA for gene silencing in human, mouse, rat THAP6

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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for THAP6


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
cytoskeleton4
nucleus2
cytosol1
extracellular1
mitochondrion1

Gene Ontology (GO): 1 cellular component term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0015630microtubule cytoskeleton IDA--

Find genes that share ontologies with THAP6           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for THAP6
Interactions:

    Search GeneGlobe Interaction Network for THAP6

STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

1 Interacting protein for THAP6 (ENSP000003090074) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
SDCBP2ENSP000003429354STRING: ENSP00000342935
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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for THAP6



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for THAP6 gene: 
NM_144721.4  

Unigene Cluster for THAP6:

THAP domain containing 6
Hs.479971  [show with all ESTs]
Unigene Representative Sequence: AL833350
13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000506261 ENST00000504218 ENST00000504384 ENST00000507557 ENST00000508105(uc010iis.1)
ENST00000311638(uc003him.3 uc010iiv.3) ENST00000380837(uc003hin.3)
ENST00000507556(uc011cbm.2) ENST00000504190 ENST00000507885(uc010iiu.1 uc003hio.1)
ENST00000502620 ENST00000503831 ENST00000514480
miRNA
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Selected qRT-PCR Assays for microRNAs that regulate THAP6 (see all 25):
hsa-miR-607 hsa-miR-126 hsa-miR-16-2* hsa-miR-631 hsa-miR-513c hsa-miR-944 hsa-miR-3661 hsa-miR-890
SwitchGear 3'UTR luciferase reporter plasmidTHAP6 3' UTR sequence
Inhib. RNA
Products:
     
OriGene RNAi products in human, mouse, rat for THAP6
Predesigned siRNA for gene silencing in human, mouse, rat THAP6
Clone
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OriGene ORF clones in mouse, rat for THAP6
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GenScript: all cDNA clones in your preferred vector: THAP6 (NM_144721)
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Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat THAP6
Primer
Products:
    
OriGene qSTAR qPCR primer pairs in human, mouse for THAP6
Pre-validated RT2 qPCR Primer Assay in human, mouse / rat THAP6
  QuantiTect SYBR Green Assays in human, mouse, rat THAP6
  QuantiFast Probe-based Assays in human, mouse, rat THAP6

Additional mRNA sequence: 

AK056959.1 AK303658.1 AK308914.1 AK309187.1 AK310575.1 AK313765.1 AL833350.1 BC022989.2 
BX647579.1 

9 DOTS entries:

DT.97826213  DT.40279395  DT.95262753  DT.70104960  DT.75159976  DT.100774661  DT.121262247  DT.97805625 
DT.121262260 

Selected AceView cDNA sequences (see all 111):

AI692280 C16675 AI743405 AI149757 AA625663 AW514141 AI863288 BE048145 
CA844235 AW303925 NM_144721 BX441095 BC022989 AI445613 AI299820 AI199523 
AW511818 AI701582 AA551198 AL833350 AI243354 AW135173 BG055369 BX111715 

GeneLoc Exon Structure

Selected Alternative Splicing Database (ASD) splice patterns (SP) for THAP6 (see all 6)    About this scheme

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b
SP1:                          -                             -               
SP2:                          -                                             
SP3:                          -                       -     -               
SP4:                                                                        
SP5:        -     -     -     -                                             


ECgene alternative splicing isoforms for THAP6

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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THAP6 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: CCTTTCACAA
THAP6 Expression
About this image

THAP6 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

THAP6 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.479971
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In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for THAP6

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for THAP6 gene from Selected species (see all 6)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Thap65 THAP domain containing 6   --   5 (45.62 cM) 91962882 
zebrafish
(Danio rerio)
Actinopterygii THAP6 (2 of 2)6
CU655961.16
Uncharacterized protein
23(a)
19(a)
1 ↔ many
1 ↔ many
19(31099647-31106581) ENSDARG00000056213
15(42902515-42912556) ENSDARG00000055690


ENSEMBL Gene Tree for THAP6 (if available)
TreeFam Gene Tree for THAP6 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for THAP6 gene
THAP92  
2 SIMAP similar genes for THAP6 using alignment to 9 protein entries:     THAP6_HUMAN (see all proteins):
THAP9    THAP3

Find genes that share paralogs with THAP6           About GenesLikeMe



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for THAP6 (see all 244)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 4 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1924268341,2
--76441725(+) AATATA/CCATTG 1 -- int10--------
rs1837287621,2
--76441733(+) TTGAAA/GCTTTT 1 -- int10--------
rs1882064291,2
--76441784(+) ATCTGC/TAGCAT 1 -- int10--------
rs1156944071,2
F--76441834(+) AAAGCA/GTGAAT 1 -- int11Minor allele frequency- G:0.01NA 120
rs1929131631,2
--76441887(+) GTTAAC/TGAATC 1 -- int10--------
rs1997957461,2
C--76441933(+) AATTAC/TATAGC 1 -- int10--------
rs349428001,2
C,F--76442052(+) CAGCCG/AGCATT 2 /S /G mis15Minor allele frequency- A:0.03NA WA CSA 4752
rs2015045071,2
--76442098(+) GCACTG/TTAAGA 2 C F mis10--------
rs1847356091,2
C--76442163(+) CTTCTA/GTCTTT 2 I V mis10--------
rs1439203651,2
C,F--76442171(+) TTTGAT/CTCTCC 2 /D syn12Minor allele frequency- C:0.00NA EU 5849

HapMap Linkage Disequilibrium report for THAP6 (76439156 - 76475683 bp)

Structural Variations
     Database of Genomic Variants (DGV) 1 variation for THAP6:    About this table    
Variant IDTypeSubtypePubMed ID
nsv7363OTHER Inversion18451855

Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing THAP6
DNA2.0 Custom Variant and Variant Library Synthesis for THAP6

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 612535    OMIM disorders: --


Find genes that share disorders with THAP6           About GenesLikeMe

Genetic Association Database (GAD): THAP6

Export disorders for THAP6 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for THAP6 gene, integrated from 10 sources (see all 12):
(articles sorted by number of sources associating them with THAP6)
    Utopia: connect your pdf to the dynamic
world of online information

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
  3. The THAP domain: a novel protein motif with similarity to the DNA-binding domain of P element transposase. (PubMed id 12575992)1, 3 Roussigne M....Girard J.P. (Trends Biochem. Sci. 2003)
  4. Toward an understanding of the protein interaction network of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (Mol. Syst. Biol. 2011)
  5. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (BMC Genomics 2007)
  6. The LIFEdb database in 2006. (PubMed id 16381901)1 Mehrle A....Wiemann S. (Nucleic Acids Res. 2006)
  7. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
  8. From ORFeome to biology: a functional genomics pipeline. (PubMed id 15489336)1 Wiemann S....Poustka A. (Genome Res. 2004)
  9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
  10. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1 Wiemann S.... Poustka A. (Genome Res. 2001)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 152815 HGNC: 23189 AceView: THAP6 Ensembl:ENSG00000174796 euGenes: HUgn152815
ECgene: THAP6 H-InvDB: THAP6

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for THAP6 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for THAP6 gene:
Search GeneIP for patents involving THAP6

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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 OriGene Antibodies for THAP6   OriGene RNAi products in human, mouse, rat for THAP6  
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 Custom PCR Arrays for THAP6 Search Chromatin IP Primers for THAP6
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 Search Tocris compounds for THAP6
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 Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

 Novus Tissue Slides
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 Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for THAP6
 SwitchGear 3'UTR luciferase reporter plasmids for THAP6
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 ThermoFisher Antibody for THAP6
 Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat THAP6
 inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for THAP6
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 LSBio Antibodies in human, mouse, rat for THAP6
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 Search Addgene for plasmids for THAP6
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GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

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