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Aliases for THAP6 Gene

Aliases for THAP6 Gene

  • THAP Domain Containing 6 2 3

External Ids for THAP6 Gene

Previous GeneCards Identifiers for THAP6 Gene

  • GC04P076832
  • GC04P076898
  • GC04P076796
  • GC04P076658
  • GC04P076439
  • GC04P072186

Summaries for THAP6 Gene

GeneCards Summary for THAP6 Gene

THAP6 (THAP Domain Containing 6) is a Protein Coding gene. An important paralog of this gene is THAP9.

Gene Wiki entry for THAP6 Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for THAP6 Gene

Genomics for THAP6 Gene

Regulatory Elements for THAP6 Gene

Genomic Location for THAP6 Gene

Start:
75,513,946 bp from pter
End:
75,550,473 bp from pter
Size:
36,528 bases
Orientation:
Plus strand

Genomic View for THAP6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for THAP6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for THAP6 Gene

Proteins for THAP6 Gene

  • Protein details for THAP6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TBB0-THAP6_HUMAN
    Recommended name:
    THAP domain-containing protein 6
    Protein Accession:
    Q8TBB0
    Secondary Accessions:
    • B4E146
    • Q5HYJ7
    • Q5JPC6

    Protein attributes for THAP6 Gene

    Size:
    222 amino acids
    Molecular mass:
    25691 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for THAP6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for THAP6 Gene

Proteomics data for THAP6 Gene at MOPED

Post-translational modifications for THAP6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

No data available for DME Specific Peptides for THAP6 Gene

Domains for THAP6 Gene

Gene Families for THAP6 Gene

HGNC:
  • THAP :THAP (C2CH-type zinc finger) domain containing

Protein Domains for THAP6 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for THAP6 Gene

Graphical View of Domain Structure for InterPro Entry

Q8TBB0

UniProtKB/Swiss-Prot:

THAP6_HUMAN :
  • Q8TBB0
Similarity:
  • Contains 1 THAP-type zinc finger.
genes like me logo Genes that share domains with THAP6: view

Function for THAP6 Gene

Gene Ontology (GO) - Molecular Function for THAP6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 25416956
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with THAP6: view

Phenotypes for THAP6 Gene

GenomeRNAi human phenotypes for THAP6:
genes like me logo Genes that share phenotypes with THAP6: view

Animal Model Products

CRISPR Products

miRNA for THAP6 Gene

miRTarBase miRNAs that target THAP6

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for THAP6

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for THAP6 Gene

Localization for THAP6 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for THAP6 Gene COMPARTMENTS Subcellular localization image for THAP6 gene
Compartment Confidence
cytoskeleton 4
nucleus 2
cytosol 1
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for THAP6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015630 microtubule cytoskeleton IDA --
genes like me logo Genes that share ontologies with THAP6: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for THAP6 Gene

Pathways for THAP6 Gene

SuperPathways for THAP6 Gene

No Data Available

Interacting Proteins for THAP6 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000309007%0d%0a9606.ENSP00000342935%0d%0a9606.ENSP00000369445%0d%0a
Selected Interacting proteins: ENSP00000309007 Q8TBB0-THAP6_HUMAN for THAP6 Gene via STRING UniProtKB

Gene Ontology (GO) - Biological Process for THAP6 Gene

None

No data available for Pathways by source for THAP6 Gene

Transcripts for THAP6 Gene

Unigene Clusters for THAP6 Gene

THAP domain containing 6:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for THAP6

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for THAP6 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b
SP1: - -
SP2: -
SP3: - - -
SP4:
SP5: - - - -
SP6: - -

Relevant External Links for THAP6 Gene

GeneLoc Exon Structure for
THAP6
ECgene alternative splicing isoforms for
THAP6

Expression for THAP6 Gene

mRNA expression in normal human tissues for THAP6 Gene

Protein differential expression in normal tissues for THAP6 Gene

This gene is overexpressed in Heart (57.5) and Monocytes (9.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for THAP6 Gene

SOURCE GeneReport for Unigene cluster for THAP6 Gene Hs.479971

genes like me logo Genes that share expressions with THAP6: view

Expression partners for THAP6 Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for THAP6 Gene

Orthologs for THAP6 Gene

This gene was present in the common ancestor of chordates.

Orthologs for THAP6 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia THAP6 35
  • 92.22 (n)
  • 92.22 (a)
THAP6 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia THAP6 35
  • 92.49 (n)
  • 91.44 (a)
THAP6 36
  • 94 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia THAP6 35
  • 99.85 (n)
  • 99.55 (a)
THAP6 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Thap6 35
  • 89.41 (n)
  • 87.38 (a)
mouse
(Mus musculus)
Mammalia Thap6 16
platypus
(Ornithorhynchus anatinus)
Mammalia THAP6 36
  • 59 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii CU655961.1 36
  • 19 (a)
OneToMany
THAP6 (2 of 2) 36
  • 23 (a)
OneToMany
Species with no ortholog for THAP6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for THAP6 Gene

ENSEMBL:
Gene Tree for THAP6 (if available)
TreeFam:
Gene Tree for THAP6 (if available)

Paralogs for THAP6 Gene

Paralogs for THAP6 Gene

Selected SIMAP similar genes for THAP6 Gene using alignment to 9 proteins:

genes like me logo Genes that share paralogs with THAP6: view

Variants for THAP6 Gene

Sequence variations from dbSNP and Humsavar for THAP6 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs9041 -- 75,529,640(+) AACTG(G/T)CCTGT utr-variant-3-prime, intron-variant
rs12791 -- 75,529,486(-) AAATG(A/G)GCAGC utr-variant-3-prime, intron-variant
rs1817387 -- 75,521,008(-) TCCTC(A/G)ATATC intron-variant
rs2126854 -- 75,527,939(-) TGTCA(A/G)AGCAA utr-variant-3-prime, intron-variant
rs2868597 -- 75,521,365(+) TTGTC(A/G)CCTTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for THAP6 Gene

Variant ID Type Subtype PubMed ID
nsv7363 OTHER Inversion 18451855

Relevant External Links for THAP6 Gene

HapMap Linkage Disequilibrium report
THAP6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for THAP6 Gene

Disorders for THAP6 Gene

Relevant External Links for THAP6

Genetic Association Database (GAD)
THAP6

No disorders were found for THAP6 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for THAP6 Gene

Publications for THAP6 Gene

  1. The THAP domain: a novel protein motif with similarity to the DNA-binding domain of P element transposase. (PMID: 12575992) Roussigne M. … Girard J.P. (Trends Biochem. Sci. 2003) 2 3
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. From ORFeome to biology: a functional genomics pipeline. (PMID: 15489336) Wiemann S. … Poustka A. (Genome Res. 2004) 3
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3

Products for THAP6 Gene

Sources for THAP6 Gene

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