Aliases for THAP6 Gene
External Ids for THAP6 Gene
- HGNC: 23189
- Entrez Gene: 152815
- Ensembl: ENSG00000174796
- OMIM: 612535
- UniProtKB: Q8TBB0
Previous GeneCards Identifiers for THAP6 Gene
- GC04P076832
- GC04P076898
- GC04P076796
- GC04P076658
- GC04P076439
- GC04P072186
Summaries for THAP6 Gene
GeneCards Summary for THAP6 Gene
THAP6 (THAP Domain Containing 6) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is THAP9.
No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for THAP6 Gene
Genomics for THAP6 Gene
Regulatory Elements for THAP6 Gene
Enhancers for THAP6 Gene
| GeneHancer Identifier | Score | Enhancer Sources | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Other Gene Targets for Enhancer |
|---|
Enhancers around THAP6 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the THAP6 gene promoter:
Regulatory Element Products
Genomic Location for THAP6 Gene
- Chromosome:
- 4
- Start:
- 75,509,860 bp from pter
- End:
- 75,550,473 bp from pter
- Size:
- 40,614 bases
- Orientation:
- Plus strand
Genomic View for THAP6 Gene
Genes around THAP6 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 4q21.1 by Ensembl
- 4q21.1 by Entrez Gene
- 4q21.21 by HGNC
THAP6 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for THAP6 Gene
Proteins for THAP6 Gene
-
Protein details for THAP6 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q8TBB0-THAP6_HUMAN
- Recommended name:
- THAP domain-containing protein 6
- Protein Accession:
- Q8TBB0
- B4E146
- Q5HYJ7
- Q5JPC6
Protein attributes for THAP6 Gene
- Size:
- 222 amino acids
- Molecular mass:
- 25691 Da
- Quaternary structure:
- No Data Available
Protein Expression for THAP6 Gene
Post-translational modifications for THAP6 Gene
Other Protein References for THAP6 Gene
Antibody Products
- Novus Biologicals Antibodies for THAP6
- Abcam antibodies for THAP6
- Search GeneTex for Antibodies for THAP6
-
Santa Cruz Biotechnology (SCBT) Antibodies for THAP6
Protein Products
-
OriGene Purified Proteins for THAP6
- Search Origene for MassSpec and Protein Over-expression Lysates for THAP6
- Origene Custom Protein Services for THAP6
- Search GeneTex for Proteins for THAP6
- Abcam proteins for THAP6
Assay Products
No data available for DME Specific Peptides for THAP6 Gene
Domains & Families for THAP6 Gene
Gene Families for THAP6 Gene
Suggested Antigen Peptide Sequences for THAP6 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q8TBB0- Similarity:
-
- Contains 1 THAP-type zinc finger.
Function for THAP6 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003677 | DNA binding | IEA | -- |
Phenotypes for THAP6 Gene
- GenomeRNAi human phenotypes for THAP6:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for THAP6 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for THAP6 gene
- Search ViGene Biosciences for THAP6
CRISPR Products
-
OriGene CRISPR knockouts for THAP6
-
Santa Cruz Biotechnology (SCBT) CRISPR for THAP6
- GenScript: Design CRISPR guide RNA sequences for THAP6
miRNA for THAP6 Gene
- miRTarBase miRNAs that target THAP6
-
- hsa-mir-106b-5p (MIRT020464)
- hsa-mir-943 (MIRT094189)
- hsa-mir-548t-5p (MIRT094192)
- hsa-mir-4318 (MIRT094193)
- hsa-mir-3609 (MIRT094194)
- hsa-mir-3688-5p (MIRT094195)
- hsa-mir-548ah-5p (MIRT094197)
- hsa-mir-548az-5p (MIRT094199)
- hsa-mir-3529-5p (MIRT694902)
- hsa-mir-599 (MIRT694903)
- hsa-mir-5089-5p (MIRT694904)
- hsa-mir-891a-3p (MIRT694905)
- hsa-mir-1290 (MIRT694906)
- hsa-mir-4771 (MIRT694907)
- hsa-mir-6506-5p (MIRT694908)
- hsa-mir-619-5p (MIRT694909)
- hsa-mir-4494 (MIRT694910)
- hsa-mir-3677-5p (MIRT694911)
- hsa-mir-4463 (MIRT694912)
- hsa-mir-548n (MIRT694913)
- hsa-mir-6805-3p (MIRT706910)
- hsa-mir-5691 (MIRT706911)
- hsa-mir-1178-3p (MIRT706912)
- hsa-mir-431-5p (MIRT706913)
- hsa-mir-3652 (MIRT706914)
- hsa-mir-4430 (MIRT706915)
- hsa-mir-122-5p (MIRT706916)
- hsa-mir-504-3p (MIRT706917)
- hsa-mir-3194-3p (MIRT706918)
- hsa-mir-3135b (MIRT706919)
- hsa-mir-3934-3p (MIRT706920)
- hsa-mir-891a-5p (MIRT706921)
- hsa-mir-367-5p (MIRT706922)
- hsa-mir-1267 (MIRT706923)
- hsa-mir-484 (MIRT706924)
- hsa-mir-3155b (MIRT706925)
- hsa-mir-3155a (MIRT706926)
- hsa-mir-454-3p (MIRT706927)
- hsa-mir-4295 (MIRT706928)
- hsa-mir-3666 (MIRT706929)
- hsa-mir-301b-3p (MIRT706930)
- hsa-mir-301a-3p (MIRT706931)
- hsa-mir-130b-3p (MIRT706932)
- hsa-mir-130a-3p (MIRT706933)
miRNA Products
- Search ViGene Biosciences for THAP6
Inhibitory RNA Products
- Origene RNAi, shRNA, rat_shrna, and siRNA products in human, mouse, rat for THAP6
- Browse OriGene Inhibitory RNA Products For THAP6
-
ViGene Biosciences ready-to-package AAV shRNAs for THAP6 gene
Clone Products
- OriGene clones in human for THAP6
- OriGene ORF clones in human,rat for THAP6
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Cell Line Products
-
ViGene Biosciences adenoviral particle packaged cDNA for THAP6 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for THAP6 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for THAP6 gene
Flow Cytometry Products
No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for THAP6 Gene
Localization for THAP6 Gene
| Compartment | Confidence |
|---|---|
| cytoskeleton | 5 |
| nucleus | 3 |
| cytosol | 1 |
| extracellular | 1 |
| mitochondrion | 1 |
No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for THAP6 Gene
Pathways & Interactions for THAP6 Gene
More details on SuperPathways for THAP6
No Data Available
Interacting Proteins for THAP6 Gene
Selected Interacting proteins:
ENSP00000309007
Q8TBB0-THAP6_HUMAN
for THAP6 Gene via
STRING
UniProtKB
No data available for Pathways by source and SIGNOR curated interactions for THAP6 Gene
Transcripts for THAP6 Gene
mRNA/cDNA for THAP6 Gene
- (8) REFSEQ mRNAs :
- (9) Additional mRNA sequences :
- (111) Selected AceView cDNA sequences:
- (13) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for THAP6 Gene
CRISPR Products
-
OriGene CRISPR knockouts for THAP6
-
Santa Cruz Biotechnology (SCBT) CRISPR for THAP6
- GenScript: Design CRISPR guide RNA sequences for THAP6
miRNA Products
- Search ViGene Biosciences for THAP6
Inhibitory RNA Products
- Origene RNAi, shRNA, rat_shrna, and siRNA products in human, mouse, rat for THAP6
- Browse OriGene Inhibitory RNA Products For THAP6
-
ViGene Biosciences ready-to-package AAV shRNAs for THAP6 gene
Clone Products
- OriGene clones in human for THAP6
- OriGene ORF clones in human,rat for THAP6
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Flow Cytometry Products
| ExUns: | 1 | ^ | 2a | · | 2b | · | 2c | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6a | · | 6b | ^ | 7a | · | 7b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | |||||||||||||||||||||
| SP2: | - | ||||||||||||||||||||||
| SP3: | - | - | - | ||||||||||||||||||||
| SP4: | |||||||||||||||||||||||
| SP5: | - | - | - | - | |||||||||||||||||||
| SP6: | - | - |
Expression for THAP6 Gene
This gene is overexpressed in Heart (57.5) and Monocytes (9.6).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for THAP6 Gene
SOURCE GeneReport for Unigene cluster for THAP6 Gene Hs.479971
Primer Products
-
OriGene qPCR primer pairs for THAP6
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for THAP6 Gene
Orthologs for THAP6 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| cow (Bos Taurus) |
Mammalia | THAP6 35 |
|
||
| THAP6 36 |
|
OneToOne | |||
| dog (Canis familiaris) |
Mammalia | THAP6 35 |
|
||
| THAP6 36 |
|
OneToOne | |||
| chimpanzee (Pan troglodytes) |
Mammalia | THAP6 35 |
|
||
| THAP6 36 |
|
OneToOne | |||
| rat (Rattus norvegicus) |
Mammalia | Thap6 35 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | THAP6 36 |
|
OneToOne | |
| zebrafish (Danio rerio) |
Actinopterygii | CU655961.1 36 |
|
OneToMany | |
| THAP6 (2 of 2) 36 |
|
OneToMany |
- Species with no ortholog for THAP6:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- mouse (Mus musculus)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for THAP6 Gene
(2) SIMAP similar genes for THAP6 Gene using alignment to 9 proteins:
Variants for THAP6 Gene
| SNP ID | Clin | Chr 04 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs9041 | -- | 75,529,640(+) | AACTG(G/T)CCTGT | intron-variant, utr-variant-3-prime | |
| rs12791 | -- | 75,529,486(-) | AAATG(A/G)GCAGC | intron-variant, utr-variant-3-prime | |
| rs1817387 | -- | 75,521,008(-) | TCCTC(A/G)ATATC | intron-variant | |
| rs2126854 | -- | 75,527,939(-) | TGTCA(A/G)AGCAA | intron-variant, utr-variant-3-prime | |
| rs2868597 | -- | 75,521,365(+) | TTGTC(A/G)CCTTA | intron-variant |
Residual Variation Intolerance Score:
86.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
3.40;
54.27% of all genes are more intolerant (likely to be disease-causing)
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for THAP6 Gene
Disorders for THAP6 Gene
Relevant External Links for THAP6
No disorders were found for THAP6 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for THAP6 Gene
Publications for THAP6 Gene
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 67
- The THAP domain: a novel protein motif with similarity to the DNA-binding domain of P element transposase. (PMID: 12575992) Roussigne M. … Girard J.P. (Trends Biochem. Sci. 2003) 2 3
- A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
- Toward an understanding of the protein interaction network of the human liver. (PMID: 21988832) Wang J. … Yang X. (Mol. Syst. Biol. 2011) 3
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
Products for THAP6 Gene
- Browse R&D Systems for Antibodies
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
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- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody ServicesOriGene Antibodies for THAP6
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for THAP6
- Search Origene for MassSpec and Protein Over-expression Lysates for THAP6
- Origene Custom Protein Services for THAP6
- Origene siRNA, shRNA, rat_shrna, and RNAi products in human, mouse, rat for THAP6
- Browse OriGene Inhibitory RNA Products For THAP6
- OriGene qPCR primer pairs for THAP6
- OriGene CRISPR knockouts for THAP6
- OriGene clones in human for THAP6
- OriGene ORF clones in human,rat for THAP6
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- GenScript: Next-day shipping cDNA clones in your preferred vector
- GenScript Custom Purified and Recombinant Proteins Services for THAP6
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- GenScript: Design CRISPR guide RNA sequences for THAP6
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for THAP6
- Novus Biologicals Antibodies for THAP6
- Novus Biologicals proteins and lysates for THAP6
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Abcam antibodies for THAP6
- Abcam proteins for THAP6
- Search for Assays for THAP6 at Abcam
- Find your target
- Search knockout validated antibodies
- Browse monoclonal antibodies
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- ViGene Biosciences adenoviral particle packaged cDNA for THAP6 gene
- ViGene Biosciences lentiviral particle packaged cDNA for THAP6 gene
- ViGene Biosciences lentiviral particle packaged cDNA for THAP6 gene
- ViGene Biosciences ready-to-package AAV shRNAs for THAP6 gene
- ViGene Biosciences ready-to-package AAV shRNAs for THAP6 gene
- ViGene Biosciences ready-to-package AAV shRNAs for THAP6 gene
- Search ViGene Biosciences for THAP6
- Search ViGene Biosciences for THAP6
- Santa Cruz Biotechnology (SCBT) Antibodies for THAP6
- Search Santa Cruz Biotechnology (SCBT) for THAP6 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for THAP6
Sources for THAP6 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) I2D
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) UniGene
- (28) AceView
- (29) RNAdb
- (30) ASD
- (31) ECgene
- (32) GeneAnnot
- (33) SAGE
- (34) SOURCE
- (35) HomoloGene
- (36) PanEnsembl
- (37) euGenes
- (38) SGD
- (39) FlyBase
- (40) WormBase
- (41) Pseudogene
- (42) DGV
- (43) dbSNP
- (44) HapMap
- (45) GenAtlas
- (46) GeneTests
- (47) HGMD
- (48) GAD
- (49) LSDB
- (50) BGMUT
- (51) HuGE
- (52) eBioscience
- (53) Atlas
- (54) Cell Signaling Technology
- (55) GenBank
- (56) H-invDB
- (57) HORDE
- (58) HUGE
- (59) IMGT
- (60) Leiden
- (61) MILLIPORE
- (62) miRBase
- (63) DME
- (64) Nature
- (65) NCBI
- (66) OriGene
- (67) PubMed
- (68) R&D Systems
- (69) Salk
- (70) TGDB
- (71) Tufts
- (72) YEDA
- (73) CROW21
- (74) Tocris
- (75) Abcam
- (76) Novus
- (77) ProSpec
- (78) Sino Biological
- (79) GenScript
- (80) Qiagen
- (81) Cloud-Clone Corp.
- (82) Enzo Life Sciences
- (83) OCA
- (84) Proteopedia
- (85) MOPED
- (86) SPIRE
- (87) neXtProt
- (88) Reactome
- (89) GeneGo (Thomson Reuters)
- (90) fRNAdb
- (91) DISEASES
- (92) SIMAP
- (93) GenomeRNAi
- (94) LifeMap
- (95) miRTarBase
- (96) MalaCards
- (97) Invitrogen
- (98) BitterDB
- (99) Vector BioLabs
- (100) ESI-BIO
- (101) RefSeq
- (102) BioSystems
- (103) MaxQB
- (104) IUPHAR
- (105) BioGPS
- (106) Illumina
- (107) COMPARTMENTS
- (108) HOMER
- (109) PaxDb
- (110) ApexBio
- (111) Addgene
- (112) Advanced Cell Diagnostics
- (113) antibodies-online
- (114) CYP
- (115) NONCODE
- (116) SwitchGear Genomics
- (117) TreeFam
- (118) PathCards
- (119) GeneReviews
- (120) GeneTex
- (121) Taconic Biosciences
- (122) GTEx
- (123) ProteomicsDB
- (124) SCBT
- (125) DGIdb
- (126) ClinicalTrials
- (127) FDA Approved Drugs
- (128) RVIS
- (129) SIGNOR
- (130) diseasecard
- (131) NIH Rare Diseases
- (132) Orphanet
- (133) UMLS
- (134) GTR
- (135) Disease Ontology
- (136) Genetics Home Reference
- (137) MeSH
- (138) MedlinePlus
- (139) CDC
- (140) NINDS
- (141) NCBI Bookshelf
- (142) ClinVar
- (143) Gene Damage Index
- (144) ViGene Biosciences
- (145) HPO
- (146) UDN
- (147) VISTA
- (148) FANTOM5
- (149) ENCODE
- (150) ProSci
- (151) Horizon