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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

THAP6 Gene

protein-coding GIFtS: 46
GCID: GC04P076439

THAP Domain Containing 6

Search for THAP6
at

MalaCards

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
About This Section

Aliases
THAP Domain Containing 6¹ ²
THAP Domain-Containing Protein 6²

External Ids:	HGNC: 23189¹	Entrez Gene: 152815²	Ensembl: ENSG00000174796⁷	OMIM: 612535⁵	UniProtKB: Q8TBB0³

Export aliases for THAP6 gene to outside databases

Previous GC identifers: GC04P076832 GC04P076898 GC04P076796 GC04P076658 GC04P072186

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for THAP6 Gene:

THAP6 (THAP domain containing 6) is a protein-coding gene. GO annotations related to this gene include DNA binding and metal ion binding. An important paralog of this gene is THAP9.

Gene Wiki entry for THAP6 Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000004.11 NT_016354.19 NC_018915.2

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the THAP6 gene promoter:
NF-1 NF-1/L LCR-F1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: THAP6 promoter sequence

Search SABiosciences Chromatin IP Primers for THAP6

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat THAP6

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q21.1 Ensembl cytogenetic band: 4q21.1 HGNC cytogenetic band: 4q21.21

THAP6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
THAP6 gene location

GeneLoc information about chromosome 4 GeneLoc Exon Structure

GeneLoc location for GC04P076439: view genomic region (about GC identifiers)

Start:	76,439,156 bp from pter	End:	76,475,683 bp from pter
Size:	36,528 bases	Orientation:	plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: THAP6_HUMAN, Q8TBB0 (See protein sequence)

Recommended Name: THAP domain-containing protein 6

Size: 222 amino acids; 25691 Da

Secondary accessions: Q5HYJ7 Q5JPC6

Alternative splicing: 2 isoforms: Q8TBB0-1 Q8TBB0-2

Explore the universe of human proteins at neXtProt for THAP6: NX_Q8TBB0

Explore proteomics data for THAP6 at MOPED

Post-translational modifications:

View modification sites using PhosphoSitePlus

View neXtProt modification sites for NX_Q8TBB0

THAP6 Protein expression data from MOPED¹, PaxDb² and MAXQB³ : About this image

REFSEQ proteins: NP_653322.1

ENSEMBL proteins:

ENSP00000422402 ENSP00000425646 ENSP00000424949 ENSP00000426760 ENSP00000309007

ENSP00000370217 ENSP00000427651 ENSP00000426581 ENSP00000424255 ENSP00000426698

ENSP00000423720

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Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0015630	microtubule cytoskeleton	IDA	--

THAP6 for ontologies About GeneDecksing

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

HGNC Gene Families:

THAP: THAP (C2CH-type zinc finger) domain containing

2 InterPro protein domains:

IPR026517 THAP6

IPR006612 Znf_C2CH

Graphical View of Domain Structure for InterPro Entry Q8TBB0

ProtoNet protein and cluster: Q8TBB0

UniProtKB/Swiss-Prot: THAP6_HUMAN, Q8TBB0

Similarity: Contains 1 THAP-type zinc finger

THAP6 for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003676	nucleic acid binding	--	--
GO:0003677	DNA binding	IEA	--
GO:0046872	metal ion binding	IEA	--

THAP6 for ontologies About GeneDecksing

Phenotypes:
1 GenomeRNAi human phenotype for THAP6:

Low eccentricity cells

Animal Models:

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inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for THAP6

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		SwitchGear 3'UTR luciferase reporter plasmid: THAP6 3' UTR sequence

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In Situ Assay
Products:

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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for THAP6

STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

1 Interacting protein for THAP6 (ENSP00000309007⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
SDCBP2	ENSP00000342935⁴	STRING: ENSP00000342935

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, IUPHAR, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for THAP6

Search CenterWatch for drugs/clinical trials and news about THAP6

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for THAP6 gene:

NM_144721.4

Unigene Cluster for THAP6:

THAP domain containing 6

Hs.479971 [show with all ESTs]

Unigene Representative Sequence: AL833350

13 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000506261 ENST00000504218 ENST00000504384 ENST00000507557 ENST00000508105(uc010iis.1)

ENST00000311638(uc003him.3 uc010iiv.3) ENST00000380837(uc003hin.3)

ENST00000507556(uc011cbm.2) ENST00000504190 ENST00000507885(uc010iiu.1 uc003hio.1)

ENST00000502620 ENST00000503831 ENST00000514480

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		8/25 QIAGEN miScript miRNA Assays for microRNAs that regulate THAP6 (see all 25):
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		SwitchGear 3'UTR luciferase reporter plasmid: THAP6 3' UTR sequence

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Additional mRNA sequence:

AK056959.1 AK303658.1 AK308914.1 AK309187.1 AK310575.1 AK313765.1 AL833350.1 BC022989.2

BX647579.1

9 DOTS entries:

DT.97826213 DT.40279395 DT.95262753 DT.70104960 DT.75159976 DT.100774661 DT.121262247 DT.97805625

DT.121262260

24/111 AceView cDNA sequences (see all 111):

CA844235 BC022989 C16675 AI199523 AI743405 AW514141 AA551198 AI445613

AI149757 AI692280 NM_144721 AI863288 AW511818 AA625663 BX441095 BE048145

AI299820 AI701582 AL833350 AW303925 BM553289 BQ224147 AI688291 BG055370

GeneLoc Exon Structure

5/6 Alternative Splicing Database (ASD) splice patterns (SP) for THAP6 (see all 6) About this scheme

ExUns:	1	^	2a	·	2b	·	2c	^	3	^	4	^	5a	·	5b	^	6a	·	6b	^	7a	·	7b
SP1:									-										-
SP2:									-
SP3:									-								-		-
SP4:
SP5:			-		-		-		-

ECgene alternative splicing isoforms for THAP6

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

THAP6 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: CCTTTCACAA

About this image

See THAP6 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for THAP6

SOURCE GeneReport for Unigene cluster: Hs.479971

SABiosciences Custom PCR Arrays for THAP6

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for THAP6

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for THAP6 gene from 2/6 species (see all 6) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Thap6⁵	THAP domain containing 6	--		5 (45.62 cM) 91962882
zebrafish (Danio rerio)	Actinopterygii	LOC100535121¹	THAP domain-containing protein 6-like	49.18(n) 38.8(a)		100535121 XM_003200095.1 XP_003200143.1

ENSEMBL Gene Tree for THAP6 (if available)
TreeFam Gene Tree for THAP6 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for THAP6 gene

THAP9²

2 SIMAP similar genes for THAP6 using alignment to 9 protein entries: THAP6_HUMAN (see all proteins):

THAP9 THAP3

THAP6 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 4 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs192426834^1,2		--	76441725(+)	`AATATA/CCATTG`	1	--	int¹		0	--	--	--	--
rs183728762^1,2		--	76441733(+)	`TTGAAA/GCTTTT`	1	--	int¹		0	--	--	--	--
rs188206429^1,2		--	76441784(+)	`ATCTGC/TAGCAT`	1	--	int¹		0	--	--	--	--
rs115694407^1,2	F	--	76441834(+)	`AAAGCA/GTGAAT`	1	--	int¹		1		NA	120
rs192913163^1,2		--	76441887(+)	`GTTAAC/TGAATC`	1	--	int¹		0	--	--	--	--
rs199795746^1,2	C	--	76441933(+)	`AATTAC/TATAGC`	1	--	int¹		0	--	--	--	--
rs34942800^1,2	C,F	--	76442052(+)	`CAGCCG/AGCATT`	2	/S /G	mis¹		5		NA WA CSA	4752
rs201504507^1,2		--	76442098(+)	`GCACTG/TTAAGA`	2	C F	mis¹		0	--	--	--	--
rs184735609^1,2	C	--	76442163(+)	`CTTCTA/GTCTTT`	2	I V	mis¹		0	--	--	--	--
rs143920365^1,2	C,F	--	76442171(+)	`TTTGAT/CTCTCC`	2	/D	syn¹		2		NA EU	5849

HapMap Linkage Disequilibrium report for THAP6 (76439156 - 76475683 bp)

Structural Variations
Database of Genomic Variants (DGV) 1 variation for THAP6: About this table

Variant ID	Type	Subtype	PubMed ID
nsv7363	OTHER	Inversion	18451855

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing THAP6

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

THAP6 for disorders About MalaCards

THAP6 for disorders About GeneDecksing

OMIM gene information: 612535 OMIM disorders: --

Genetic Association Database (GAD): THAP6

Export disorders for THAP6 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for THAP6 gene, integrated from 9 sources (see all 12):
(articles sorted by number of sources associating them with THAP6)

Utopia: connect your pdf to the dynamic
world of online information

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
The THAP domain: a novel protein motif with similarity to the DNA-binding domain of P element transposase. (PubMed id 12575992)^{1, 3} Roussigne M....Girard J.P. (2003)
Toward an understanding of the protein interaction net work of the human liver. (PubMed id 21988832)¹ Wang J....Yang X. (2011)
The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)² Bechtel S.... Schupp I. (2007)
The LIFEdb database in 2006. (PubMed id 16381901)¹ Mehrle A....Wiemann S. (2006)
Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)¹ Kimura K.... Sugano S. (2006)
From ORFeome to biology: a functional genomics pipeline. (PubMed id 15489336)¹ Wiemann S....Poustka A. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)
Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)¹ Wiemann S.... Poustka A. (2001)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 152815	HGNC: 23189	AceView: THAP6	Ensembl:ENSG00000174796	euGenes: HUgn152815
ECgene: THAP6	H-InvDB: THAP6

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for THAP6	Pharmacogenomics, SNPs, Pathways

Intellectual Property for THAP6 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for THAP6 gene:
Search GeneIP for patents involving THAP6

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section


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	OriGene ORF clones in mouse, rat for THAP6		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat THAP6
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	GenScript Custom Purified and Recombinant Proteins Services for THAP6		GenScript cDNA clones with any tag delivered in your preferred vector for THAP6
	GenScript Custom Assay Services for THAP6		GenScript Custom Superior Antibodies Services for THAP6
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	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
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Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for THAP6

	SwitchGear 3'UTR luciferase reporter plasmids for THAP6
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ThermoFisher Antibody for THAP6

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat THAP6

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Customized:

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LSBio Antibodies in human, mouse, rat for THAP6

GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013

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Category			TGFB1 (GIFtS: 73) transforming growth factor, beta 1
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The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes THAP6 gene at Home site.

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THAP6 Gene

THAP Domain Containing 6

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THAP6 Gene

THAP Domain Containing 6

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