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THAP6 Gene(Protein Coding)

THAP Domain Containing 6

GCID:
GC04P075513
GIFtS:
45
Genes Participants
UDN Logo

Aliases for THAP6 Gene

Aliases for THAP6 Gene

  • THAP Domain Containing 6 2 3 5

External Ids for THAP6 Gene

Previous GeneCards Identifiers for THAP6 Gene

  • GC04P076832
  • GC04P076898
  • GC04P076796
  • GC04P076658
  • GC04P076439
  • GC04P072186

Summaries for THAP6 Gene

GeneCards Summary for THAP6 Gene

THAP6 (THAP Domain Containing 6) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is THAP9.

Gene Wiki entry for THAP6 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for THAP6 Gene

Genomics for THAP6 Gene

Products:

  1. Regulatory Element

Regulatory Elements for THAP6 Gene

Enhancers for THAP6 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04G076154 1.2 dbSUPER 22.3 +646.3 646325 2.4 CREB3L1 MLX DMAP1 FEZF1 YY1 SLC30A9 ZNF143 ZNF416 ZNF263 SP3 RPL7P17 NUP54 THAP6 SCARB2 CDKL2 FAM47E RNU6-1000P NAAA GC04P076210
GH04G076027 1.7 FANTOM5 Ensembl ENCODE 12.1 +518.6 518575 1.1 HNRNPUL1 HDGF PKNOX1 AGO1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 ART3 CXCL9 SDAD1 CXCL10 CXCL11 THAP6 NAAA GC04M075923 RPL36P8
GH04G076152 0.9 dbSUPER 20.6 +643.4 643424 2.1 SIN3A EGR1 ZSCAN5C PRPF4 CREM EGR2 ZNF174 SMAD5 CEBPB TSHZ1 NUP54 THAP6 ART3 SDAD1 RPL7P17 GC04P076210
GH04G076233 1.7 Ensembl ENCODE dbSUPER 10.2 +726.1 726059 5.5 CREB3L1 MLX DMAP1 FEZF1 YY1 ZNF143 ZNF263 SP3 NFYC TBX21 FAM47E RPL7P17 SCARB2 THAP6 RCHY1 ENSG00000251185 STBD1 LOC105377286
GH04G076146 1.2 ENCODE 13.2 +638.3 638312 2.5 CREB3L1 AGO1 FEZF1 DMAP1 YY1 ZNF416 ZNF143 ZNF548 SP3 TBX21 NUP54 ART3 THAP6 SDAD1 GC04P076146
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around THAP6 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the THAP6 gene promoter:

Genomic Location for THAP6 Gene

Chromosome:
4
Start:
75,509,860 bp from pter
End:
75,550,473 bp from pter
Size:
40,614 bases
Orientation:
Plus strand

Genomic View for THAP6 Gene

Genes around THAP6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
THAP6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for THAP6 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for THAP6 Gene

Proteins for THAP6 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for THAP6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TBB0-THAP6_HUMAN
    Recommended name:
    THAP domain-containing protein 6
    Protein Accession:
    Q8TBB0
    Secondary Accessions:
    • B4E146
    • Q5HYJ7
    • Q5JPC6

    Protein attributes for THAP6 Gene

    Size:
    222 amino acids
    Molecular mass:
    25691 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for THAP6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for THAP6 Gene

Protein Expression for THAP6 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for THAP6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for THAP6 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for THAP6 Gene

Domains & Families for THAP6 Gene

Gene Families for THAP6 Gene

HGNC:

Protein Domains for THAP6 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for THAP6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with THAP6: view

No data available for UniProtKB/Swiss-Prot for THAP6 Gene

Function for THAP6 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Gene Ontology (GO) - Molecular Function for THAP6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 25416956
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with THAP6: view

Phenotypes for THAP6 Gene

GenomeRNAi human phenotypes for THAP6:
genes like me logo Genes that share phenotypes with THAP6: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for THAP6 Gene

Localization for THAP6 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for THAP6 gene
Compartment Confidence
cytoskeleton 5
nucleus 3
extracellular 1
mitochondrion 1
cytosol 1

Gene Ontology (GO) - Cellular Components for THAP6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015630 microtubule cytoskeleton IDA --
genes like me logo Genes that share ontologies with THAP6: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for THAP6 Gene

Pathways & Interactions for THAP6 Gene

SuperPathways for THAP6 Gene

PathCards logo More details on SuperPathways for THAP6
No Data Available

Interacting Proteins for THAP6 Gene

Selected Interacting proteins: Q8TBB0-THAP6_HUMAN for THAP6 Gene via UniProtKB IID

Gene Ontology (GO) - Biological Process for THAP6 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for THAP6 Gene

Drugs & Compounds for THAP6 Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for THAP6 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for THAP6 Gene

(9) REFSEQ mRNAs :
(9) Additional mRNA sequences :
(111) Selected AceView cDNA sequences:
(13) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for THAP6 Gene

THAP domain containing 6:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for THAP6 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b
SP1: - -
SP2: -
SP3: - - -
SP4:
SP5: - - - -
SP6: - -

Relevant External Links for THAP6 Gene

GeneLoc Exon Structure for
THAP6
ECgene alternative splicing isoforms for
THAP6

Expression for THAP6 Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for THAP6 Gene

mRNA expression in normal human tissues for THAP6 Gene
mRNA expression by BioGPS for THAP6 GenemRNA expression by GTEx for THAP6 Gene

Protein differential expression in normal tissues from HIPED for THAP6 Gene

This gene is overexpressed in Heart (57.5) and Monocytes (9.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for THAP6 Gene



Protein tissue co-expression partners for THAP6 Gene

NURSA nuclear receptor signaling pathways regulating expression of THAP6 Gene:

THAP6

SOURCE GeneReport for Unigene cluster for THAP6 Gene:

Hs.479971

Evidence on tissue expression from TISSUES for THAP6 Gene

  • Heart(4.2)
  • Nervous system(2)
genes like me logo Genes that share expression patterns with THAP6: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for THAP6 Gene

Orthologs for THAP6 Gene

This gene was present in the common ancestor of chordates.

Orthologs for THAP6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia THAP6 34 35
  • 99.85 (n)
dog
(Canis familiaris)
 Mammalia THAP6 34 35
  • 92.49 (n)
cow
(Bos Taurus)
 Mammalia THAP6 34 35
  • 92.22 (n)
rat
(Rattus norvegicus)
 Mammalia Thap6 34
  • 89.41 (n)
platypus
(Ornithorhynchus anatinus)
 Mammalia THAP6 35
  • 59 (a)
 OneToOne
zebrafish
(Danio rerio)
 Actinopterygii THAP6 (2 of 2) 35
  • 23 (a)
 OneToMany
CU655961.1 35
  • 19 (a)
 OneToMany
Species where no ortholog for THAP6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for THAP6 Gene

ENSEMBL:
Gene Tree for THAP6 (if available)
TreeFam:
Gene Tree for THAP6 (if available)

Paralogs for THAP6 Gene

Paralogs for THAP6 Gene

(2) SIMAP similar genes for THAP6 Gene using alignment to 9 proteins:

genes like me logo Genes that share paralogs with THAP6: view

Variants for THAP6 Gene

Sequence variations from dbSNP and Humsavar for THAP6 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs1000407828 -- 75,517,460(+) GAGTA(-/T)TTTAC intron-variant
rs1000528743 -- 75,518,562(+) TCATT(G/T)TATCA intron-variant
rs1000587755 -- 75,512,164(+) TGAGG(G/T)GGACA intron-variant, upstream-variant-2KB
rs1000595253 -- 75,517,190(+) TTTTT(A/G)TATTT intron-variant
rs1000632925 -- 75,523,686(+) CTACC(C/T)AGCTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for THAP6 Gene

Variant ID Type Subtype PubMed ID
esv3601031 CNV loss 21293372
nsv594687 CNV loss 21841781
nsv7363 OTHER inversion 18451855

Variation tolerance for THAP6 Gene

Residual Variation Intolerance Score: 86.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.40; 54.27% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for THAP6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
THAP6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for THAP6 Gene

Disorders for THAP6 Gene

Relevant External Links for THAP6

Genetic Association Database (GAD)
THAP6
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
THAP6

No disorders were found for THAP6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for THAP6 Gene

Publications for THAP6 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. The THAP domain: a novel protein motif with similarity to the DNA-binding domain of P element transposase. (PMID: 12575992) Roussigne M. … Girard J.P. (Trends Biochem. Sci. 2003) 2 3 64
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 64
  5. Toward an understanding of the protein interaction network of the human liver. (PMID: 21988832) Wang J. … Yang X. (Mol. Syst. Biol. 2011) 3 64

Products for THAP6 Gene

Sources for THAP6 Gene

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