THAP6 Gene

Aliases
for THAP6 gene

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Previous GC identifers: GC04P076832 GC04P076898 GC04P076796 GC04P076658 GC04P072186

Summaries
for THAP6 gene

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Genomic Views
for THAP6 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:

NC_000004.11  NT_016354.20  NC_018915.2  

SwitchGear Promoter luciferase reporter plasmid: THAP6 promoter sequence

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat THAP6

THAP6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P076439:  view genomic region     (about GC identifiers)

Proteins
for THAP6 gene

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, antibodies-online, and/or GeneTex,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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Explore the universe of human proteins at neXtProt for THAP6: NX_Q8TBB0

Explore proteomics data for THAP6 at MOPED


See THAP6 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

THAP6 Human Recombinant Protein Products:

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	antibodies-online peptides for THAP6

THAP6 Antibody Products:

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THAP6 Assay Products:

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	Search eBioscience for ELISAs for THAP6
	antibodies-online kits for THAP6 (2 products)

Domains /
Families
for THAP6 gene

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GenesLikeMe)
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ProtoNet protein and cluster: Q8TBB0

Find genes that share domains with THAP6           About GenesLikeMe

Function
for THAP6 gene

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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     Gene Ontology (GO): 3 molecular function terms:    About this table

genOway: Develop your customized and physiologically relevant rodent model for THAP6

miRNA Products:		miRTarBase miRNAs that target THAP6: hsa-mir-106b-5p (MIRT020464)
		Block miRNA regulation of human, mouse, rat THAP6 using miScript Target Protectors
		Selected qRT-PCR Assays for microRNAs that regulate THAP6 (see all 25):
		hsa-miR-607 hsa-miR-126 hsa-miR-16-2* hsa-miR-631 hsa-miR-513c hsa-miR-944 hsa-miR-3661 hsa-miR-890
		SwitchGear 3'UTR luciferase reporter plasmid: THAP6 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for THAP6
		Predesigned siRNA for gene silencing in human, mouse, rat THAP6

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for THAP6

Clone Products:		OriGene clones in human, mouse for THAP6 (see all 5) OriGene ORF clones in mouse, rat for THAP6 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: THAP6 (NM_144721)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for THAP6
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat THAP6

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for THAP6
		Browse ESI BIO Cell Lines and PureStem Progenitors for THAP6

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for THAP6

Localization
for THAP6 gene

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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Subcellular locations from COMPARTMENTS: 

Compartment	Confidence
cytoskeleton	4
nucleus	2
cytosol	1
extracellular	1
mitochondrion	1

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Gene Ontology (GO): 1 cellular component term:    About this table

Pathways & Interactions
for THAP6 gene

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GenesLikeMe, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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Drugs & Compounds
for THAP6 gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, Sets of similar genes according to GenesLikeMe)
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Transcripts
for THAP6 gene

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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Expression
for THAP6 gene

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GenesLikeMe, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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THAP6 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: CCTTTCACAA

About this image

Primer Products:		OriGene qSTAR qPCR primer pairs in human, mouse for THAP6
		Pre-validated RT2 qPCR Primer Assay in human, mouse / rat THAP6
		QuantiTect SYBR Green Assays in human, mouse, rat THAP6
		QuantiFast Probe-based Assays in human, mouse, rat THAP6

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for THAP6

Orthologs
for THAP6 gene

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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Paralogs
for THAP6 gene

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68,Sets of similar genes according to GenesLikeMe)
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Paralogs for THAP6 gene

THAP9²  

2 SIMAP similar genes for THAP6 using alignment to 9 protein entries:     THAP6_HUMAN (see all proteins):

THAP9    THAP3

Find genes that share paralogs with THAP6           About GenesLikeMe

Genomic Variants
for THAP6 gene

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for THAP6 (see all 244)    About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 4 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs1924268341,2		--	76441725(+)	AATATA/CCATTG	1	--	int1		0	--	--	--	--
rs1837287621,2		--	76441733(+)	TTGAAA/GCTTTT	1	--	int1		0	--	--	--	--
rs1882064291,2		--	76441784(+)	ATCTGC/TAGCAT	1	--	int1		0	--	--	--	--
rs1156944071,2	F	--	76441834(+)	AAAGCA/GTGAAT	1	--	int1		1		NA	120
rs1929131631,2		--	76441887(+)	GTTAAC/TGAATC	1	--	int1		0	--	--	--	--
rs1997957461,2	C	--	76441933(+)	AATTAC/TATAGC	1	--	int1		0	--	--	--	--
rs349428001,2	C,F	--	76442052(+)	CAGCCG/AGCATT	2	/S /G	mis1		5		NA WA CSA	4752
rs2015045071,2		--	76442098(+)	GCACTG/TTAAGA	2	C F	mis1		0	--	--	--	--
rs1847356091,2	C	--	76442163(+)	CTTCTA/GTCTTT	2	I V	mis1		0	--	--	--	--
rs1439203651,2	C,F	--	76442171(+)	TTTGAT/CTCTCC	2	/D	syn1		2		NA EU	5849

HapMap Linkage Disequilibrium report for THAP6 (76439156 - 76475683 bp)

Structural Variations
     Database of Genomic Variants (DGV) 1 variation for THAP6:    About this table    

Variant ID	Type	Subtype	PubMed ID
nsv7363	OTHER	Inversion	18451855

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing THAP6

DNA2.0 Custom Variant and Variant Library Synthesis for THAP6

Disorders / Diseases
for THAP6 gene

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB, Sets of similar genes according to GenesLikeMe)
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Publications
for THAP6 gene

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for THAP6 gene, integrated from 10 sources (see all 12): (articles sorted by number of sources associating them with THAP6)

Utopia: connect your pdf to the dynamic world of online information

1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S.... Malek J. (Genome Res. 2004)
2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (Nat. Genet. 2004)
3. The THAP domain: a novel protein motif with similarity to the DNA-binding domain of P element transposase. (PubMed id 12575992)^{1, 3} Roussigne M....Girard J.P. (Trends Biochem. Sci. 2003)
4. Toward an understanding of the protein interaction network of the human liver. (PubMed id 21988832)¹ Wang J....Yang X. (Mol. Syst. Biol. 2011)
5. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)² Bechtel S.... Schupp I. (BMC Genomics 2007)
6. The LIFEdb database in 2006. (PubMed id 16381901)¹ Mehrle A....Wiemann S. (Nucleic Acids Res. 2006)
7. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)¹ Kimura K.... Sugano S. (Genome Res. 2006)
8. From ORFeome to biology: a functional genomics pipeline. (PubMed id 15489336)¹ Wiemann S....Poustka A. (Genome Res. 2004)
9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
10. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)¹ Wiemann S.... Poustka A. (Genome Res. 2001)

External Searches for THAP6 gene

Genome Databases showing THAP6 gene

Other Databases showing THAP6 gene

Specialized Databases showing THAP6 gene

Products
for THAP6 gene

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, GeneTex, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
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