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Aliases for THAP5 Gene

Aliases for THAP5 Gene

  • THAP Domain Containing 5 2 3

External Ids for THAP5 Gene

Previous GeneCards Identifiers for THAP5 Gene

  • GC07M107718
  • GC07M107763
  • GC07M107796
  • GC07M107990
  • GC07M108194
  • GC07M102571

Summaries for THAP5 Gene

GeneCards Summary for THAP5 Gene

THAP5 (THAP Domain Containing 5) is a Protein Coding gene. GO annotations related to this gene include protease binding. An important paralog of this gene is THAP3.

UniProtKB/Swiss-Prot for THAP5 Gene

  • May be a regulator of cell cycle: THAP5 overexpression in human cell lines causes cell cycle arrest at G2/M phase

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for THAP5 Gene

Genomics for THAP5 Gene

Regulatory Elements for THAP5 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for THAP5 Gene

Start:
108,554,543 bp from pter
End:
108,569,768 bp from pter
Size:
15,226 bases
Orientation:
Minus strand

Genomic View for THAP5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for THAP5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for THAP5 Gene

Proteins for THAP5 Gene

  • Protein details for THAP5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z6K1-THAP5_HUMAN
    Recommended name:
    THAP domain-containing protein 5
    Protein Accession:
    Q7Z6K1
    Secondary Accessions:

    Protein attributes for THAP5 Gene

    Size:
    395 amino acids
    Molecular mass:
    45416 Da
    Quaternary structure:
    • Interacts with HTRA2; under apoptotic conditions.
    SequenceCaution:
    • Sequence=AAH53634.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=EAL24383.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for THAP5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for THAP5 Gene

Proteomics data for THAP5 Gene at MOPED

Post-translational modifications for THAP5 Gene

Other Protein References for THAP5 Gene

No data available for DME Specific Peptides for THAP5 Gene

Domains for THAP5 Gene

Gene Families for THAP5 Gene

HGNC:
  • THAP :THAP (C2CH-type zinc finger) domain containing

Protein Domains for THAP5 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for THAP5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q7Z6K1

UniProtKB/Swiss-Prot:

THAP5_HUMAN :
  • Q7Z6K1
Similarity:
  • Contains 1 THAP-type zinc finger.
genes like me logo Genes that share domains with THAP5: view

Function for THAP5 Gene

Molecular function for THAP5 Gene

UniProtKB/Swiss-Prot Function: May be a regulator of cell cycle: THAP5 overexpression in human cell lines causes cell cycle arrest at G2/M phase

Gene Ontology (GO) - Molecular Function for THAP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002020 protease binding IPI 19502560
GO:0003676 nucleic acid binding --
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with THAP5: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for THAP5 Gene

Localization for THAP5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for THAP5 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for THAP5 Gene COMPARTMENTS Subcellular localization image for THAP5 gene
Compartment Confidence
nucleus 5
cytosol 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for THAP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm IDA --
genes like me logo Genes that share ontologies with THAP5: view

Pathways for THAP5 Gene

SuperPathways for THAP5 Gene

No Data Available

Interacting Proteins for THAP5 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000400500%0d%0a9606.ENSP00000298492%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: Q7Z6K1-THAP5_HUMAN ENSP00000400500 for THAP5 Gene via MINT STRING I2D

Gene Ontology (GO) - Biological Process for THAP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007049 cell cycle IEA --
GO:0045786 negative regulation of cell cycle IMP 19502560
genes like me logo Genes that share ontologies with THAP5: view

No data available for Pathways by source for THAP5 Gene

Transcripts for THAP5 Gene

Unigene Clusters for THAP5 Gene

THAP domain containing 5:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for THAP5

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for THAP5 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b · 4c
SP1: - - -
SP2: - -
SP3: -
SP4: -

Relevant External Links for THAP5 Gene

GeneLoc Exon Structure for
THAP5
ECgene alternative splicing isoforms for
THAP5

Expression for THAP5 Gene

mRNA expression in normal human tissues for THAP5 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for THAP5 Gene

SOURCE GeneReport for Unigene cluster for THAP5 Gene Hs.707689

mRNA Expression by UniProt/SwissProt for THAP5 Gene

Q7Z6K1-THAP5_HUMAN
Tissue specificity: Highly expressed in the heart. Also found in brain and skeletal muscle.
genes like me logo Genes that share expressions with THAP5: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for THAP5 Gene

Orthologs for THAP5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for THAP5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia THAP5 35
  • 99.83 (n)
  • 99.75 (a)
THAP5 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia THAP5 35
  • 87.41 (n)
  • 82.39 (a)
THAP5 36
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia THAP5 35
  • 89.17 (n)
  • 86.04 (a)
THAP5 36
  • 86 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia THAP5 36
  • 65 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia THAP5 36
  • 90 (a)
OneToOne
chicken
(Gallus gallus)
Aves THAP5 35
  • 62.52 (n)
  • 51.27 (a)
THAP5 36
  • 47 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia THAP5 36
  • 38 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia thap5 35
  • 51.83 (n)
  • 40.56 (a)
Species with no ortholog for THAP5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for THAP5 Gene

ENSEMBL:
Gene Tree for THAP5 (if available)
TreeFam:
Gene Tree for THAP5 (if available)

Paralogs for THAP5 Gene

Paralogs for THAP5 Gene

Selected SIMAP similar genes for THAP5 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for THAP5 Gene

genes like me logo Genes that share paralogs with THAP5: view

Variants for THAP5 Gene

Sequence variations from dbSNP and Humsavar for THAP5 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs40939 -- 108,562,348(+) ATCTC(C/T)CCATA utr-variant-3-prime
rs40940 -- 108,562,450(+) ATTAA(C/T)ATTAG utr-variant-3-prime
rs40941 -- 108,562,481(+) TATGG(C/T)CAAAA utr-variant-3-prime
rs40942 -- 108,562,606(+) GCCAC(C/T)CTTTA utr-variant-3-prime
rs40943 -- 108,564,035(+) TAAAT(A/G)AGTAT utr-variant-3-prime

Relevant External Links for THAP5 Gene

HapMap Linkage Disequilibrium report
THAP5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for THAP5 Gene

Disorders for THAP5 Gene

Relevant External Links for THAP5

Genetic Association Database (GAD)
THAP5
Human Genome Epidemiology (HuGE) Navigator
THAP5
genes like me logo Genes that share disorders with THAP5: view

No data available for UniProtKB/Swiss-Prot for THAP5 Gene

Publications for THAP5 Gene

  1. THAP5 is a human cardiac-specific inhibitor of cell cycle that is cleaved by the proapoptotic Omi/HtrA2 protease during cell death. (PMID: 19502560) Balakrishnan M.P. … Zervos A.S. (Am. J. Physiol. 2009) 3 4
  2. The THAP domain: a novel protein motif with similarity to the DNA-binding domain of P element transposase. (PMID: 12575992) Roussigne M. … Girard J.P. (Trends Biochem. Sci. 2003) 2 3
  3. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer S.W. … Tsui L.-C. (Science 2003) 3 4
  4. Functional proteomics mapping of a human signaling pathway. (PMID: 15231748) Colland F. … Gauthier J.M. (Genome Res. 2004) 3
  5. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3

Products for THAP5 Gene

Sources for THAP5 Gene

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