THAP5 Gene
protein-coding GIFtS: 45
GCID: GC07M108194
|
|
THAP domain containing 5
| |
Aliases
for THAP5 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| THAP Domain Containing 51 2 | | DKFZp313O11321 | | THAP Domain-Containing Protein 52 |
Export aliases for THAP5 gene to outside databasesPrevious GC identifers: GC07M107718 GC07M107763 GC07M107796 GC07M107990 GC07M102571 |
Summaries
for THAP5 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: THAP5_HUMAN, Q7Z6K1Function: May be a regulator of cell cycle: THAP5 overexpression in human cell lines causes cell cycle arrest at G2/Mphase
|
Genomic Views
for THAP5 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000007.13 NC_018918.1 NT_007933.15 NT_079596.2
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the THAP5 gene promoter:
POU2F1 POU2F1a Pax-2 Pax-2a Nkx2-5
Other transcription factors
Search SABiosciences Chromatin IP Primers for THAP5
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat THAP5 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 7q31.1 Ensembl cytogenetic band: 7q31.1 HGNC cytogenetic band: 7q22.3THAP5 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 7 GeneLoc Exon Structure GeneLoc location for GC07M108194: view genomic region
(about GC identifiers)
Start:
|
108,194,987 bp from pter |
End:
|
108,210,194 bp from pter |
Size:
|
15,208 bases |
Orientation:
|
minus strand |
1 alternative location:
| Chr7-,CRA_TCAG 107,569,889-107,577,381 |
|
Proteins
for THAP5 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: THAP5_HUMAN, Q7Z6K1 (See
protein sequence)Recommended Name: THAP domain-containing protein 5 Size: 395 amino acids; 45416 Da
Subunit: Interacts with HTRA2; under apoptotic conditions
Subcellular location: Nucleus
Sequence caution: Sequence=AAH53634.1; Type=Erroneous initiation; Note=Translation N-terminally extended;Sequence=EAL24383.1; Type=Erroneous gene model prediction;Alternative splicing: 2 isoforms: Q7Z6K1-1 Q7Z6K1-2 Explore the universe of human proteins at neXtProt for THAP5: NX_Q7Z6K1
Post-translational modifications:
Cleaved by HTRA2 during apoptosis1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q7Z6K1
THAP5 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001123947.1 NP_872335.2
ENSEMBL proteins: ENSP00000400500 ENSP00000322440 ENSP00000415841
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table
THAP5 for ontologies About GeneDecksing
THAP5 Antibody Products:
Assay Products for THAP5: |
Protein
Domains /
Families
for THAP5 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
THAP5 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q7Z6K1ProtoNet protein and cluster: Q7Z6K1 UniProtKB/Swiss-Prot: THAP5_HUMAN, Q7Z6K1Similarity: Contains 1 THAP-type zinc finger |
Function
for THAP5 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: THAP5_HUMAN, Q7Z6K1Function: May be a regulator of cell cycle: THAP5 overexpression in human cell lines causes cell cycle arrest at G2/Mphase
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for THAP5 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for THAP5 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): THAP5 (NM_001130475) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for THAP5 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat THAP5 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for THAP5 |
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table
THAP5 for ontologies About GeneDecksing
|
Pathways & Interactions
for THAP5 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for THAP5
STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)
3 Interacting proteins for THAP5 (Q7Z6K12, 3 ENSP000004005004) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table
THAP5 for ontologies About GeneDecksing
|
Drugs & Compounds
for THAP5 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for THAP5
Search CenterWatch for drugs/clinical trials and news about THAP5
|
Transcripts
for THAP5 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for THAP5 gene (2 alternative transcripts): NM_001130475.1 NM_182529.2 Unigene Cluster for THAP5: THAP domain containing 5 Hs.707689 [show with all ESTs]Unigene Representative Sequence: NM_1825298 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000468884 ENST00000415914(uc003vfl.3 uc003vfm.3) ENST00000313516
ENST00000493722 ENST00000438865 ENST00000446771 ENST00000412935 ENST00000484452
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for THAP5 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for THAP5 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): THAP5 (NM_001130475) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for THAP5 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat THAP5 |
Additional cDNA sequence: AL833137.1 BC016973.1 BC040353.1 BC053634.1 11 DOTS entries: DT.70103440 DT.95156924 DT.121054297 DT.406553 DT.100738827 DT.91981888 DT.100762241 DT.100752341 DT.101975427 DT.121054230 DT.101975699 24/82 AceView cDNA sequences (see all 82): AI917649 AI376239 BU753298 BU616488 BQ024141 BC053634 AW407519 AI032020 AA724524 BG575430 NM_182529 AI806817 CD516314 CA418235 BX483062 CB148114 BQ441619 BI830307 BI560073 BU568978 BG500677 BG568721 BX089307 BF939577
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for THAP5 About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3a | · | 3b | · | 3c | ^ | 4a | · | 4b | · | 4c |
|---|
|
| SP1: | | | | | | | - | | | | - | | - | | | | | | | | |
| SP2: | | | | | | | - | | | | | | - | | | | | | | | |
| SP3: | | | | | | | | | | | | | - | | | | | | | | |
| SP4: | | | | | | | - | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for THAP5
|
Expression
for THAP5 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| THAP5 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See THAP5 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for THAP5
SOURCE GeneReport for Unigene cluster: Hs.707689
UniProtKB/Swiss-Prot: THAP5_HUMAN, Q7Z6K1Tissue specificity: Highly expressed in the heart. Also found in brain and skeletal muscle
SABiosciences Custom PCR Arrays for THAP5
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for THAP5
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat THAP5 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat THAP5 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat THAP5 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for THAP5 |
Orthologs
for THAP5 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for THAP5 gene from 2/7 species (see all 7) About this table
ENSEMBL Gene Tree for THAP5 (if available)
TreeFam Gene Tree for THAP5 (if available) |
Paralogs
for THAP5 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for THAP5 gene
- THAP32 THAP12 ENSG000002580642 THAP22 THAP82
3 SIMAP similar genes for THAP5 using alignment to 2 protein entries: THAP5_HUMAN (see all proteins):LOC285872 THAP8 PRKRIR
THAP5 for paralogs About GeneDecksing
2 Pseudogenes.org Pseudogenes for THAP5
PGOHUM00000257057 PGOHUM00000233094
|
Genomic Variants
for THAP5 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 7 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for THAP5 (108194987 - 108210194 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for THAP5: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing THAP5 |
|
Disorders
/ Diseases
for THAP5 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
THAP5 for disorders About GeneDecksing
OMIM gene information: 612534
OMIM disorders: --
2  diseases for THAP5: About MalaCardsmelanoma myocardial infarcation
Human Genome Epidemiology (HuGE) Navigator: THAP5 (2 documents)
Export disorders for THAP5 gene to outside databases
|
Publications
for THAP5 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for THAP5 gene, integrated from 9 sources (see all 11):
(articles sorted by number of sources associating them with THAP5) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- THAP5 is a human cardiac-specific inhibitor of cell cycle that is cleaved by the proapoptotic Omi/HtrA2 protease during cell death. (PubMed id 19502560)1, 2 Balakrishnan M.P....Zervos A.S. (2009)
- The THAP domain: a novel protein motif with similarity to the DNA-binding domain of P element transposase. (PubMed id 12575992)1, 3 Roussigne M....Girard J.P. (2003)
- Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)1, 2 Scherer S.W.... Tsui L.-C. (2003)
- Large-scale genome-wide association study of Asian pop ulation reveals genetic factors in FRMD4A and other loci influencing smoking ini tiation and nicotine dependence. (PubMed id 22006218)1 Yoon D....Park T. (2012)
- THAP5 is a DNA-binding transcriptional repressor that is regulated in melanoma cells during DNA damage-induced cell death. (PubMed id 21110952)1 Balakrishnan M.P....Zervos A.S. (2011)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Regulation of Abro1/KIAA0157 during myocardial infarc tion and cell death reveals a novel cardioprotective mechanism for Lys63-specif ic deubiquitination. (PubMed id 21195082)1 Cilenti L....Zervos A.S. (2011)
- Generalist genes analysis of DNA markers associated w ith mathematical ability and disability reveals shared influence across ages an d abilities. (PubMed id 20602751)1 Docherty S.J....Plomin R. (2010)
- hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
|
External Searches for THAP5 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing THAP5 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing THAP5 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing THAP5 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for THAP5 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for THAP5 gene:
Search GeneIP for patents involving THAP5
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for THAP5 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for THAP5 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for THAP5 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for THAP5 | | | OriGene Protein Over-expression Lysate for THAP5 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for THAP5 | | OriGene 3'-UTR Clone for THAP5 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for THAP5 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for THAP5 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for THAP5 | | OriGene Custom Protein Services for THAP5 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat THAP5 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing THAP5 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat THAP5 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat THAP5 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat THAP5 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat THAP5 |
| |
 |  |  |  | |
| | | | Search Tocris compounds for THAP5 |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | THAP5 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for THAP5 |
|  |  |  | | | | Search ThermoFisher Antibodies for THAP5 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat THAP5 |
|
|
|
|
