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THAP5 Gene

protein-coding   GIFtS: 43
GCID: GC07M108194

THAP Domain Containing 5

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
THAP Domain Containing 51 2
THAP Domain-Containing Protein 52

External Ids:    HGNC: 231881   Entrez Gene: 1684512   Ensembl: ENSG000001776837   OMIM: 6125345   UniProtKB: Q7Z6K13   

Export aliases for THAP5 gene to outside databases

Previous GC identifers: GC07M107718 GC07M107763 GC07M107796 GC07M107990 GC07M102571


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for THAP5 Gene:
THAP5 (THAP domain containing 5) is a protein-coding gene. Diseases associated with THAP5 include nicotine dependence, and myocardial infarction. GO annotations related to this gene include protease binding. An important paralog of this gene is THAP3.

UniProtKB/Swiss-Prot: THAP5_HUMAN, Q7Z6K1
Function: May be a regulator of cell cycle: THAP5 overexpression in human cell lines causes cell cycle arrest at
G2/M phase




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the THAP5 gene promoter:
         POU2F1   POU2F1a   Pax-2   Pax-2a   Nkx2-5   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTHAP5 promoter sequence
   Search Chromatin IP Primers for THAP5

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat THAP5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q31.1   Ensembl cytogenetic band:  7q31.1   HGNC cytogenetic band: 7q22.3

THAP5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
THAP5 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M108194:  view genomic region     (about GC identifiers)

Start:
108,194,987 bp from pter      End:
108,210,194 bp from pter
Size:
15,208 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 107,569,889-107,577,381     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: THAP5_HUMAN, Q7Z6K1 (See protein sequence)
Recommended Name: THAP domain-containing protein 5  
Size: 395 amino acids; 45416 Da
Subunit: Interacts with HTRA2; under apoptotic conditions
Sequence caution: Sequence=AAH53634.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=EAL24383.1; Type=Erroneous gene model prediction;
Alternative splicing: 2 isoforms:  Q7Z6K1-1   Q7Z6K1-2   

Explore the universe of human proteins at neXtProt for THAP5: NX_Q7Z6K1

Explore proteomics data for THAP5 at MOPED

Post-translational modifications: 

  • Cleaved by HTRA2 during apoptosis1
  • Ubiquitination2 at Lys360
  • Modification sites at PhosphoSitePlus

  • See THAP5 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (5 alternative transcripts): 
    NP_001123947.1  NP_001274527.1  NP_001274528.1  NP_001274530.1  NP_872335.2  

    ENSEMBL proteins: 
     ENSP00000400500   ENSP00000322440   ENSP00000415841  

    THAP5 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    Novus Biologicals THAP5 Protein
    Novus Biologicals THAP5 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
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    Cloud-Clone Corp. Proteins for THAP5

    THAP5 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Abcam antibodies for THAP5
    Cloud-Clone Corp. Antibodies for THAP5
    Search ThermoFisher Antibodies for THAP5
    LSBio Antibodies in human, mouse, rat for THAP5

    THAP5 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for THAP5
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    GenScript Custom Assay Services for THAP5
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for THAP5
    Cloud-Clone Corp. CLIAs for THAP5


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    THAP: THAP (C2CH-type zinc finger) domain containing

    2 InterPro protein domains:
     IPR006612 Znf_C2CH
     IPR026518 THAP5_mammal

    Graphical View of Domain Structure for InterPro Entry Q7Z6K1

    ProtoNet protein and cluster: Q7Z6K1

    UniProtKB/Swiss-Prot: THAP5_HUMAN, Q7Z6K1
    Similarity: Contains 1 THAP-type zinc finger


    THAP5 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: THAP5_HUMAN, Q7Z6K1
    Function: May be a regulator of cell cycle: THAP5 overexpression in human cell lines causes cell cycle arrest at
    G2/M phase

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002020protease binding IPI19502560
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0046872metal ion binding IEA--
         
    THAP5 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for THAP5
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for THAP5

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for THAP5
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for THAP5

    miRNA
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    Block miRNA regulation of human, mouse, rat THAP5 using miScript Target Protectors
    6 qRT-PCR Assays for microRNAs that regulate THAP5:
    hsa-miR-3926 hsa-miR-875-3p hsa-miR-576-5p hsa-miR-516b hsa-miR-4263 hsa-miR-1299
    SwitchGear 3'UTR luciferase reporter plasmidTHAP5 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for THAP5
    Predesigned siRNA for gene silencing in human, mouse, rat THAP5

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for THAP5

    Clone
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    OriGene clones in human, mouse for THAP5 (see all 14)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): THAP5 (NM_001130475)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for THAP5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat THAP5

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for THAP5
    Browse ESI BIO Cell Lines and PureStem Progenitors for THAP5 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for THAP5


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    THAP5_HUMAN, Q7Z6K1: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2
    mitochondrion1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--

    THAP5 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for THAP5
    Interactions:

        Search GeneGlobe Interaction Network for THAP5

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    3 Interacting proteins for THAP5 (Q7Z6K12, 3 ENSP000004005004) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SKILP127572, 3MINT-61648 I2D: score=2 
    FAM175BQ150183, ENSP000002984924I2D: score=1 STRING: ENSP00000298492
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007049cell cycle IEA--
    GO:0045786negative regulation of cell cycle IMP19502560

    THAP5 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for THAP5



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for THAP5 gene (5 alternative transcripts): 
    NM_001130475.2  NM_001287598.1  NM_001287599.1  NM_001287601.1  NM_182529.3  

    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000468884 ENST00000415914(uc003vfl.3 uc003vfm.3) ENST00000313516
    ENST00000493722 ENST00000438865 ENST00000446771 ENST00000412935 ENST00000484452

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat THAP5 using miScript Target Protectors
    6 qRT-PCR Assays for microRNAs that regulate THAP5:
    hsa-miR-3926 hsa-miR-875-3p hsa-miR-576-5p hsa-miR-516b hsa-miR-4263 hsa-miR-1299
    SwitchGear 3'UTR luciferase reporter plasmidTHAP5 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for THAP5
    Predesigned siRNA for gene silencing in human, mouse, rat THAP5
    Clone
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    OriGene clones in human, mouse for THAP5 (see all 14)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): THAP5 (NM_001130475)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for THAP5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat THAP5
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for THAP5
    OriGene qSTAR qPCR primer pairs in human, mouse for THAP5
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat THAP5
      QuantiTect SYBR Green Assays in human, mouse, rat THAP5
      QuantiFast Probe-based Assays in human, mouse, rat THAP5

    Selected AceView cDNA sequences (see all 82):

    BU753298 BU616488 CB148114 BQ024141 AI917649 AI032020 AI376239 AW407519 
    AI806817 AA724524 NM_182529 CA418235 CD516314 BX483062 BC053634 BG575430 
    BX440727 BF244164 BI461364 BG500677 BX424437 AI510797 R27314 BI766810 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for THAP5    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b · 4c
    SP1:                    -           -     -                     
    SP2:                    -                 -                     
    SP3:                                      -                     
    SP4:                    -                                       


    ECgene alternative splicing isoforms for THAP5

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    THAP5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    THAP5 Expression
    About this image

    THAP5 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    THAP5 Protein Expression

    UniProtKB/Swiss-Prot: THAP5_HUMAN, Q7Z6K1
    Tissue specificity: Highly expressed in the heart. Also found in brain and skeletal muscle

        Custom PCR Arrays for THAP5
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for THAP5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for THAP5 gene from Selected species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    dog
    (Canis familiaris)
    Mammalia THAP51 THAP domain containing 5 89.17(n)
    86.04(a)
      482404  XM_539521.4  XP_539521.2 
    chicken
    (Gallus gallus)
    Aves THAP51 THAP domain containing 5 62.52(n)
    51.27(a)
      417784  NM_001006230.1  NP_001006230.1 
    lizard
    (Anolis carolinensis)
    Reptilia THAP56
    THAP domain containing 5
    38(a)
    1 ↔ 1
    1(133480023-133488083)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia thap51 THAP domain containing 5 51.83(n)
    40.56(a)
      100487932  XM_002932813.2  XP_002932859.1 


    ENSEMBL Gene Tree for THAP5 (if available)
    TreeFam Gene Tree for THAP5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for THAP5 gene
    THAP32  THAP12  ENSG000002580642  THAP22  THAP82  
    3 SIMAP similar genes for THAP5 using alignment to 2 protein entries:     THAP5_HUMAN (see all proteins):
    LOC285872    THAP8    PRKRIR

    THAP5 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for THAP5
    PGOHUM00000257057 PGOHUM00000233094


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for THAP5 (see all 113)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1909463851,2
    --108202241(+) CTACCA/GGCTCT 2 -- ds50010--------
    rs737131491,2
    C--108202256(+) ATGTAG/AGAAGA 2 -- ds50012Minor allele frequency- A:0.22WA 120
    rs22149111,2
    C,F,A--108202260(+) aggaaG/Tagaaa 2 -- ds50018Minor allele frequency- T:0.24NA WA CSA EA 368
    rs1448733011,2
    --108202338(+) CAATGC/TTGTTC 2 -- ds50010--------
    rs21904031,2
    C,F,A,H--108202345(+) gttcaA/Cagttt 2 -- ds500125Minor allele frequency- C:0.26NS EA NA WA CSA 2764
    rs21904041,2
    C,F,A--108202580(+) GTCAAC/ATTTTA 2 -- ds50016Minor allele frequency- A:0.25NA WA CSA EA 364
    rs20671721,2
    C,F--108202724(+) TCTGTATTAA/
            
    ATTAA
    2 -- ut315Minor allele frequency- -:0.26EU NA EA MN 430
    rs409391,2
    C,F,A,H--108202792(+) ATCTCC/TCCATA 2 -- ut3123Minor allele frequency- T:0.21MN NS EA NA WA CSA 2520
    rs1409102771,2
    --108202806(+) TATGCA/TAAAAT 2 -- ut310--------
    rs1812398341,2
    C--108202840(+) CCTAAC/GACATT 2 -- ut310--------

    HapMap Linkage Disequilibrium report for THAP5 (108194987 - 108210194 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for THAP5: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing THAP5
    DNA2.0 Custom Variant and Variant Library Synthesis for THAP5

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 612534    OMIM disorders: --

    3 diseases for THAP5:    
    About MalaCards
    nicotine dependence    myocardial infarction    melanoma


    THAP5 for disorders           About GeneDecksing

    Genetic Association Database (GAD): THAP5
    Human Genome Epidemiology (HuGE) Navigator: THAP5 (2 documents)

    Export disorders for THAP5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for THAP5 gene, integrated from 10 sources (see all 14):
    (articles sorted by number of sources associating them with THAP5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. THAP5 is a human cardiac-specific inhibitor of cell cycle that is cleaved by the proapoptotic Omi/HtrA2 protease during cell death. (PubMed id 19502560)1, 2 Balakrishnan M.P....Zervos A.S. (Am. J. Physiol. 2009)
    2. The THAP domain: a novel protein motif with similarity to the DNA-binding domain of P element transposase. (PubMed id 12575992)1, 3 Roussigne M....Girard J.P. (Trends Biochem. Sci. 2003)
    3. Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)1, 2 Scherer S.W.... Tsui L.-C. (Science 2003)
    4. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    5. Large-scale genome-wide association study of Asian population reveals genetic factors in FRMD4A and other loci influencing smoking initiation and nicotine dependence. (PubMed id 22006218)1 Yoon D....Park T. (Hum. Genet. 2012)
    6. THAP5 is a DNA-binding transcriptional repressor that is regulated in melanoma cells during DNA damage-induced cell death. (PubMed id 21110952)1 Balakrishnan M.P....Zervos A.S. (Biochem. Biophys. Res. Commun. 2011)
    7. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    8. Regulation of Abro1/KIAA0157 during myocardial infarction and cell death reveals a novel cardioprotective mechanism for Lys63-specific deubiquitination. (PubMed id 21195082)1 Cilenti L....Zervos A.S. (J. Mol. Cell. Cardiol. 2011)
    9. Single-nucleotide polymorphisms, acute rejection, and severity of tubulitis in kidney transplantation, accounting for center-to-center variation. (PubMed id 21085059)4 Israni A....Oetting W.S. (Transplantation 2010)
    10. Generalist genes analysis of DNA markers associated with mathematical ability and disability reveals shared influence across ages and abilities. (PubMed id 20602751)1 Docherty S.J....Plomin R. (BMC Genet. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 168451 HGNC: 23188 AceView: THAP5 Ensembl:ENSG00000177683 euGenes: HUgn168451
    ECgene: THAP5 H-InvDB: THAP5

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for THAP5 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for THAP5 gene:
    Search GeneIP for patents involving THAP5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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