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Aliases for THAP5 Gene

Aliases for THAP5 Gene

  • THAP Domain Containing 5 2 3 5

External Ids for THAP5 Gene

Previous GeneCards Identifiers for THAP5 Gene

  • GC07M107718
  • GC07M107763
  • GC07M107796
  • GC07M107990
  • GC07M108194
  • GC07M102571

Summaries for THAP5 Gene

GeneCards Summary for THAP5 Gene

THAP5 (THAP Domain Containing 5) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding and protease binding. An important paralog of this gene is THAP4.

UniProtKB/Swiss-Prot for THAP5 Gene

  • Has sequence-specific DNA-binding activity and can function as transcriptional repressor (in vitro) (PubMed:21110952). May be a regulator of cell cycle: THAP5 overexpression in human cell lines causes cell cycle arrest at G2/M phase (PubMed:19502560).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for THAP5 Gene

Genomics for THAP5 Gene

Regulatory Elements for THAP5 Gene

Enhancers for THAP5 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07F108567 1.2 ENCODE 35.1 -0.1 -69 4.5 MLX CREB3L1 FEZF1 DMAP1 YY1 SLC30A9 ZNF263 SP3 NFYC MEF2D THAP5 CBLL1 ENSG00000272854 RPL7P32 PNPLA8 LOC105375448
GH07F108523 1.2 ENCODE 34.8 +43.8 43793 5.3 HDGF PKNOX1 CREB3L1 MLX ARID4B SIN3A DMAP1 YY1 CBX5 ZNF207 THAP5 PNPLA8 RPL7P32 CBLL1 ENSG00000272854 DNAJB9 GC07M108510 GC07P108537
GH07F108503 0.9 Ensembl ENCODE 36.1 +66.2 66157 1.2 HDGF CTCF TRIM22 MAFG CBX5 POLR2A SMARCA4 PBX2 MLLT1 PRDM1 THAP5 PNPLA8 DNAJB9 RPL7P32 PIR53132
GH07F108453 1.3 FANTOM5 ENCODE 18.5 +114.3 114272 3.2 PKNOX1 SIN3A FEZF1 ZNF2 YY1 GLIS2 ZNF548 FOS SP3 REST THAP5 ENSG00000273055 LAMB1 RPL7P32 NRCAM GC07M108348
GH07F108529 0.6 ENCODE 36.3 +40.2 40244 0.5 ARID1B PKNOX1 RFX1 HLF PBX2 DPF2 KDM1A THAP5 PNPLA8 DNAJB9 GC07P108537 GC07M108510
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around THAP5 on UCSC Golden Path with GeneCards custom track

Promoters for THAP5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000632340 -332 3401 MLX CREB3L1 FEZF1 DMAP1 YY1 SLC30A9 ZNF263 SP3 NFYC MEF2D

Genomic Location for THAP5 Gene

Chromosome:
7
Start:
108,554,543 bp from pter
End:
108,569,768 bp from pter
Size:
15,226 bases
Orientation:
Minus strand

Genomic View for THAP5 Gene

Genes around THAP5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
THAP5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for THAP5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for THAP5 Gene

Proteins for THAP5 Gene

  • Protein details for THAP5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z6K1-THAP5_HUMAN
    Recommended name:
    THAP domain-containing protein 5
    Protein Accession:
    Q7Z6K1

    Protein attributes for THAP5 Gene

    Size:
    395 amino acids
    Molecular mass:
    45416 Da
    Quaternary structure:
    • Interacts with HTRA2; under apoptotic conditions (PubMed:19502560). Interacts with FAM175B (PubMed:21195082).
    SequenceCaution:
    • Sequence=AAH53634.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=EAL24383.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for THAP5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for THAP5 Gene

Post-translational modifications for THAP5 Gene

Other Protein References for THAP5 Gene

No data available for DME Specific Peptides for THAP5 Gene

Domains & Families for THAP5 Gene

Gene Families for THAP5 Gene

Protein Domains for THAP5 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for THAP5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q7Z6K1

UniProtKB/Swiss-Prot:

THAP5_HUMAN :
  • Contains 1 THAP-type zinc finger.
Similarity:
  • Contains 1 THAP-type zinc finger.
genes like me logo Genes that share domains with THAP5: view

Function for THAP5 Gene

Molecular function for THAP5 Gene

UniProtKB/Swiss-Prot Function:
Has sequence-specific DNA-binding activity and can function as transcriptional repressor (in vitro) (PubMed:21110952). May be a regulator of cell cycle: THAP5 overexpression in human cell lines causes cell cycle arrest at G2/M phase (PubMed:19502560).
UniProtKB/Swiss-Prot Induction:
Up-regulated both in response to UV light treatment and cisplatin, agents that cause DNA damage (at protein level).

Gene Ontology (GO) - Molecular Function for THAP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002020 protease binding IPI 19502560
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with THAP5: view

Phenotypes for THAP5 Gene

genes like me logo Genes that share phenotypes with THAP5: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for THAP5 Gene

Localization for THAP5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for THAP5 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for THAP5 gene
Compartment Confidence
nucleus 5
cytosol 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for THAP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 19502560
genes like me logo Genes that share ontologies with THAP5: view

Pathways & Interactions for THAP5 Gene

SuperPathways for THAP5 Gene

No Data Available

Interacting Proteins for THAP5 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000400500%0d%0a9606.ENSP00000298492%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: Q7Z6K1-THAP5_HUMAN ENSP00000400500 for THAP5 Gene via MINT STRING IID

Gene Ontology (GO) - Biological Process for THAP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0007049 cell cycle IEA --
GO:0045786 negative regulation of cell cycle IMP 19502560
genes like me logo Genes that share ontologies with THAP5: view

No data available for Pathways by source and SIGNOR curated interactions for THAP5 Gene

Transcripts for THAP5 Gene

Unigene Clusters for THAP5 Gene

THAP domain containing 5:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for THAP5 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b · 4c
SP1: - - -
SP2: - -
SP3: -
SP4: -

Relevant External Links for THAP5 Gene

GeneLoc Exon Structure for
THAP5
ECgene alternative splicing isoforms for
THAP5

Expression for THAP5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for THAP5 Gene

Protein differential expression in normal tissues from HIPED for THAP5 Gene

This gene is overexpressed in Ovary (36.5), NK cells (17.5), and Pancreas (14.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for THAP5 Gene



Protein tissue co-expression partners for THAP5 Gene

NURSA nuclear receptor signaling pathways regulating expression of THAP5 Gene:

THAP5

SOURCE GeneReport for Unigene cluster for THAP5 Gene:

Hs.707689

mRNA Expression by UniProt/SwissProt for THAP5 Gene:

Q7Z6K1-THAP5_HUMAN
Tissue specificity: Detected in heart (PubMed:19502560, PubMed:21195082). Detected in brain and muscle (at protein level) (PubMed:19502560). Highly expressed in the heart. Also found in brain and skeletal muscle (PubMed:19502560, PubMed:21195082).
genes like me logo Genes that share expression patterns with THAP5: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for THAP5 Gene

Orthologs for THAP5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for THAP5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia THAP5 34 35
  • 99.83 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia THAP5 35
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia THAP5 34 35
  • 89.17 (n)
cow
(Bos Taurus)
Mammalia THAP5 34 35
  • 87.41 (n)
oppossum
(Monodelphis domestica)
Mammalia THAP5 35
  • 65 (a)
OneToOne
chicken
(Gallus gallus)
Aves THAP5 34 35
  • 62.52 (n)
lizard
(Anolis carolinensis)
Reptilia THAP5 35
  • 38 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia thap5 34
  • 51.83 (n)
Species where no ortholog for THAP5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for THAP5 Gene

ENSEMBL:
Gene Tree for THAP5 (if available)
TreeFam:
Gene Tree for THAP5 (if available)

Paralogs for THAP5 Gene

Paralogs for THAP5 Gene

(3) SIMAP similar genes for THAP5 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for THAP5 Gene

genes like me logo Genes that share paralogs with THAP5: view

Variants for THAP5 Gene

Sequence variations from dbSNP and Humsavar for THAP5 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs10258344 -- 108,568,143(+) TTGAG(C/G)CTGGG intron-variant, upstream-variant-2KB
rs10259656 -- 108,563,371(+) cgttt(C/T)tacta utr-variant-3-prime
rs10270723 -- 108,571,142(+) ACATT(A/C)TATTG intron-variant, upstream-variant-2KB
rs111562755 -- 108,570,378(+) CCAGT(C/T)GCCTT intron-variant, upstream-variant-2KB
rs111647889 -- 108,564,662(+) GAATT(A/G)CTTGT reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for THAP5 Gene

Variant ID Type Subtype PubMed ID
nsv970570 CNV duplication 23825009
esv3572052 CNV loss 25503493

Variation tolerance for THAP5 Gene

Residual Variation Intolerance Score: 40.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.61; 45.18% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for THAP5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
THAP5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for THAP5 Gene

Disorders for THAP5 Gene

Relevant External Links for THAP5

Genetic Association Database (GAD)
THAP5
Human Genome Epidemiology (HuGE) Navigator
THAP5
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
THAP5

No disorders were found for THAP5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for THAP5 Gene

Publications for THAP5 Gene

  1. THAP5 is a DNA-binding transcriptional repressor that is regulated in melanoma cells during DNA damage-induced cell death. (PMID: 21110952) Balakrishnan M.P. … Zervos A.S. (Biochem. Biophys. Res. Commun. 2011) 3 4 64
  2. Regulation of Abro1/KIAA0157 during myocardial infarction and cell death reveals a novel cardioprotective mechanism for Lys63-specific deubiquitination. (PMID: 21195082) Cilenti L. … Zervos A.S. (J. Mol. Cell. Cardiol. 2011) 3 4 64
  3. THAP5 is a human cardiac-specific inhibitor of cell cycle that is cleaved by the proapoptotic Omi/HtrA2 protease during cell death. (PMID: 19502560) Balakrishnan M.P. … Zervos A.S. (Am. J. Physiol. 2009) 3 4 64
  4. The THAP domain: a novel protein motif with similarity to the DNA-binding domain of P element transposase. (PMID: 12575992) Roussigne M. … Girard J.P. (Trends Biochem. Sci. 2003) 2 3 64
  5. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer S.W. … Tsui L.-C. (Science 2003) 3 4 64

Products for THAP5 Gene

Sources for THAP5 Gene

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