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Aliases for THAP5 Gene

Aliases for THAP5 Gene

  • THAP Domain Containing 5 2 3 5

External Ids for THAP5 Gene

Previous GeneCards Identifiers for THAP5 Gene

  • GC07M107718
  • GC07M107763
  • GC07M107796
  • GC07M107990
  • GC07M108194
  • GC07M102571

Summaries for THAP5 Gene

GeneCards Summary for THAP5 Gene

THAP5 (THAP Domain Containing 5) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding and protease binding. An important paralog of this gene is THAP3.

UniProtKB/Swiss-Prot for THAP5 Gene

  • Has sequence-specific DNA-binding activity and can function as transcriptional repressor (in vitro) (PubMed:21110952). May be a regulator of cell cycle: THAP5 overexpression in human cell lines causes cell cycle arrest at G2/M phase (PubMed:19502560).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for THAP5 Gene

Genomics for THAP5 Gene

Regulatory Elements for THAP5 Gene

Enhancers for THAP5 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around THAP5 on UCSC Golden Path with GeneCards custom track

Promoters for THAP5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around THAP5 on UCSC Golden Path with GeneCards custom track

Genomic Location for THAP5 Gene

108,554,543 bp from pter
108,569,768 bp from pter
15,226 bases
Minus strand

Genomic View for THAP5 Gene

Genes around THAP5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
THAP5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for THAP5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for THAP5 Gene

Proteins for THAP5 Gene

  • Protein details for THAP5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    THAP domain-containing protein 5
    Protein Accession:

    Protein attributes for THAP5 Gene

    395 amino acids
    Molecular mass:
    45416 Da
    Quaternary structure:
    • Interacts with HTRA2; under apoptotic conditions (PubMed:19502560). Interacts with FAM175B (PubMed:21195082).
    • Sequence=AAH53634.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=EAL24383.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for THAP5 Gene


neXtProt entry for THAP5 Gene

Proteomics data for THAP5 Gene at MOPED

Post-translational modifications for THAP5 Gene

Other Protein References for THAP5 Gene

No data available for DME Specific Peptides for THAP5 Gene

Domains & Families for THAP5 Gene

Gene Families for THAP5 Gene

Protein Domains for THAP5 Gene


Suggested Antigen Peptide Sequences for THAP5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 THAP-type zinc finger.
  • Contains 1 THAP-type zinc finger.
genes like me logo Genes that share domains with THAP5: view

Function for THAP5 Gene

Molecular function for THAP5 Gene

UniProtKB/Swiss-Prot Function:
Has sequence-specific DNA-binding activity and can function as transcriptional repressor (in vitro) (PubMed:21110952). May be a regulator of cell cycle: THAP5 overexpression in human cell lines causes cell cycle arrest at G2/M phase (PubMed:19502560).
UniProtKB/Swiss-Prot Induction:
Up-regulated both in response to UV light treatment and cisplatin, agents that cause DNA damage (at protein level).

Phenotypes for THAP5 Gene

genes like me logo Genes that share phenotypes with THAP5: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for THAP5 Gene

Localization for THAP5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for THAP5 Gene

Subcellular locations from

Jensen Localization Image for THAP5 Gene COMPARTMENTS Subcellular localization image for THAP5 gene
Compartment Confidence
nucleus 5
cytosol 2
mitochondrion 1

No data available for Gene Ontology (GO) - Cellular Components for THAP5 Gene

Pathways & Interactions for THAP5 Gene

SuperPathways for THAP5 Gene

No Data Available

Interacting Proteins for THAP5 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
Selected Interacting proteins: Q7Z6K1-THAP5_HUMAN ENSP00000400500 for THAP5 Gene via MINT STRING I2D

Gene Ontology (GO) - Biological Process for THAP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0045786 negative regulation of cell cycle IMP 19502560
genes like me logo Genes that share ontologies with THAP5: view

No data available for Pathways by source and SIGNOR curated interactions for THAP5 Gene

Drugs & Compounds for THAP5 Gene

No Compound Related Data Available

Transcripts for THAP5 Gene

Unigene Clusters for THAP5 Gene

THAP domain containing 5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for THAP5 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b · 4c
SP1: - - -
SP2: - -
SP3: -
SP4: -

Relevant External Links for THAP5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for THAP5 Gene

mRNA expression in normal human tissues for THAP5 Gene

Protein differential expression in normal tissues from HIPED for THAP5 Gene

This gene is overexpressed in Ovary (36.5), NK cells (17.5), and Pancreas (14.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for THAP5 Gene

SOURCE GeneReport for Unigene cluster for THAP5 Gene Hs.707689

mRNA Expression by UniProt/SwissProt for THAP5 Gene

Tissue specificity: Detected in heart (PubMed:19502560, PubMed:21195082). Detected in brain and muscle (at protein level) (PubMed:19502560). Highly expressed in the heart. Also found in brain and skeletal muscle (PubMed:19502560, PubMed:21195082).
genes like me logo Genes that share expression patterns with THAP5: view

Protein tissue co-expression partners for THAP5 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for THAP5 Gene

Orthologs for THAP5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for THAP5 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia THAP5 35
  • 87.41 (n)
  • 82.39 (a)
THAP5 36
  • 85 (a)
(Canis familiaris)
Mammalia THAP5 35
  • 89.17 (n)
  • 86.04 (a)
THAP5 36
  • 86 (a)
(Pan troglodytes)
Mammalia THAP5 35
  • 99.83 (n)
  • 99.75 (a)
THAP5 36
  • 100 (a)
(Monodelphis domestica)
Mammalia THAP5 36
  • 65 (a)
(Ornithorhynchus anatinus)
Mammalia THAP5 36
  • 90 (a)
(Gallus gallus)
Aves THAP5 35
  • 62.52 (n)
  • 51.27 (a)
THAP5 36
  • 47 (a)
(Anolis carolinensis)
Reptilia THAP5 36
  • 38 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia thap5 35
  • 51.83 (n)
  • 40.56 (a)
Species with no ortholog for THAP5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for THAP5 Gene

Gene Tree for THAP5 (if available)
Gene Tree for THAP5 (if available)

Paralogs for THAP5 Gene

Paralogs for THAP5 Gene

(3) SIMAP similar genes for THAP5 Gene using alignment to 2 proteins: Pseudogenes for THAP5 Gene

genes like me logo Genes that share paralogs with THAP5: view

Variants for THAP5 Gene

Sequence variations from dbSNP and Humsavar for THAP5 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs17155919 -- 108,567,558(+) GATCA(C/T)GTTTC intron-variant
rs35772928 -- 108,565,051(+) ACTTC(-/T)TTTCT reference, frameshift-variant, utr-variant-5-prime
rs55988854 -- 108,564,972(+) GATGG(A/G)GCACA reference, missense, utr-variant-5-prime
rs40943 -- 108,564,035(+) TAAAT(A/G)AGTAT utr-variant-3-prime
rs40944 -- 108,565,356(+) GAGGT(A/C/G)AGGAG intron-variant

Variation tolerance for THAP5 Gene

Residual Variation Intolerance Score: 40.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.61; 45.18% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for THAP5 Gene

Disorders for THAP5 Gene

Relevant External Links for THAP5

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for THAP5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for THAP5 Gene

Publications for THAP5 Gene

  1. THAP5 is a DNA-binding transcriptional repressor that is regulated in melanoma cells during DNA damage-induced cell death. (PMID: 21110952) Balakrishnan M.P. … Zervos A.S. (Biochem. Biophys. Res. Commun. 2011) 3 4 67
  2. The THAP domain: a novel protein motif with similarity to the DNA-binding domain of P element transposase. (PMID: 12575992) Roussigne M. … Girard J.P. (Trends Biochem. Sci. 2003) 2 3
  3. Large-scale genome-wide association study of Asian population reveals genetic factors in FRMD4A and other loci influencing smoking initiation and nicotine dependence. (PMID: 22006218) Yoon D. … Park T. (Hum. Genet. 2012) 3
  4. Regulation of Abro1/KIAA0157 during myocardial infarction and cell death reveals a novel cardioprotective mechanism for Lys63-specific deubiquitination. (PMID: 21195082) Cilenti L. … Zervos A.S. (J. Mol. Cell. Cardiol. 2011) 3
  5. Generalist genes analysis of DNA markers associated with mathematical ability and disability reveals shared influence across ages and abilities. (PMID: 20602751) Docherty S.J. … Plomin R. (BMC Genet. 2010) 3

Products for THAP5 Gene

Sources for THAP5 Gene