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Aliases for THAP4 Gene

Aliases for THAP4 Gene

  • THAP Domain Containing 4 2 3
  • THAP Domain-Containing Protein 4 3
  • CGI-36 3
  • PP238 3

External Ids for THAP4 Gene

Summaries for THAP4 Gene

GeneCards Summary for THAP4 Gene

THAP4 (THAP Domain Containing 4) is a Protein Coding gene.

Gene Wiki entry for THAP4 Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for THAP4 Gene

Genomics for THAP4 Gene

Genomic Location for THAP4 Gene

Start:
241,584,405 bp from pter
End:
241,637,449 bp from pter
Size:
53,045 bases
Orientation:
Minus strand

Genomic View for THAP4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for THAP4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for THAP4 Gene

Regulatory Elements for THAP4 Gene

Proteins for THAP4 Gene

  • Protein details for THAP4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WY91-THAP4_HUMAN
    Recommended name:
    THAP domain-containing protein 4
    Protein Accession:
    Q8WY91
    Secondary Accessions:
    • Q53NU7
    • Q6GRN0
    • Q6IPJ3
    • Q9NW26
    • Q9Y325

    Protein attributes for THAP4 Gene

    Size:
    577 amino acids
    Molecular mass:
    62890 Da
    Quaternary structure:
    • Homodimer.
    SequenceCaution:
    • Sequence=AAH00247.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH09439.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAA91560.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for THAP4 Gene

    Alternative splice isoforms for THAP4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for THAP4 Gene

Proteomics data for THAP4 Gene at MOPED

Post-translational modifications for THAP4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for THAP4 Gene

No data available for DME Specific Peptides for THAP4 Gene

Domains for THAP4 Gene

Gene Families for THAP4 Gene

HGNC:
  • THAP :THAP (C2CH-type zinc finger) domain containing

Protein Domains for THAP4 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

THAP4_HUMAN
Similarity:
  • Contains 1 THAP-type zinc finger.:
    • Q8WY91
genes like me logo Genes that share domains with THAP4: view

Function for THAP4 Gene

Gene Ontology (GO) - Molecular Function for THAP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with THAP4: view

Phenotypes for THAP4 Gene

GenomeRNAi human phenotypes for THAP4:
genes like me logo Genes that share phenotypes with THAP4: view

miRNA for THAP4 Gene

miRTarBase miRNAs that target THAP4

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for THAP4 Gene

Localization for THAP4 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for THAP4 Gene COMPARTMENTS Subcellular localization image for THAP4 gene
Compartment Confidence
cytosol 2
nucleus 2
endoplasmic reticulum 1
extracellular 1
mitochondrion 1

No data available for Gene Ontology (GO) - Cellular Components for THAP4 Gene

Pathways for THAP4 Gene

SuperPathways for THAP4 Gene

No Data Available

Interacting Proteins for THAP4 Gene

Gene Ontology (GO) - Biological Process for THAP4 Gene

None

No data available for Pathways by source for THAP4 Gene

Transcripts for THAP4 Gene

Unigene Clusters for THAP4 Gene

THAP domain containing 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for THAP4 Gene

No ASD Table

Relevant External Links for THAP4 Gene

GeneLoc Exon Structure for
THAP4
ECgene alternative splicing isoforms for
THAP4

Expression for THAP4 Gene

mRNA expression in normal human tissues for THAP4 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for THAP4 Gene

SOURCE GeneReport for Unigene cluster for THAP4 Gene Hs.435759

genes like me logo Genes that share expressions with THAP4: view

Orthologs for THAP4 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for THAP4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia THAP4 36
  • 99.13 (n)
  • 99.31 (a)
THAP4 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia THAP4 36
  • 82.37 (n)
  • 80.43 (a)
THAP4 37
  • 80 (a)
OneToOne
dog
(Canis familiaris)
Mammalia THAP4 37
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Thap4 36
  • 84.39 (n)
  • 84.98 (a)
Thap4 16
Thap4 37
  • 85 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia THAP4 37
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia THAP4 37
  • 71 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Thap4 36
  • 83.95 (n)
  • 85.66 (a)
chicken
(Gallus gallus)
Aves THAP4 36
  • 80.12 (n)
  • 88.3 (a)
THAP4 37
  • 71 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia THAP4 37
  • 68 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.33974 36
tropical clawed frog
(Silurana tropicalis)
Amphibia thap4 36
  • 60.32 (n)
  • 60.63 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6292 36
zebrafish
(Danio rerio)
Actinopterygii thap4 36
  • 64.63 (n)
  • 57.93 (a)
thap4 37
  • 57 (a)
OneToOne
wufb76g01 36
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003313 36
  • 55.84 (n)
  • 43.95 (a)
worm
(Caenorhabditis elegans)
Secernentea C52G5.2 37
  • 29 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G79260 36
  • 49.17 (n)
  • 40.62 (a)
rice
(Oryza sativa)
Liliopsida Os01g0679600 36
  • 52.81 (n)
  • 36.36 (a)
Species with no ortholog for THAP4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for THAP4 Gene

ENSEMBL:
Gene Tree for THAP4 (if available)
TreeFam:
Gene Tree for THAP4 (if available)

Paralogs for THAP4 Gene

No data available for Paralogs for THAP4 Gene

Variants for THAP4 Gene

Sequence variations from dbSNP and Humsavar for THAP4 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs3208142 -- 241,633,431(-) TCCTC(C/T)AAGCA synonymous-codon, reference
rs4072903 -- 241,597,717(+) CCTCA(A/G)TCCTG intron-variant
rs4072904 -- 241,598,291(-) GGCCC(C/T)GTGGG intron-variant
rs4072905 -- 241,598,277(-) TGGTC(A/G)GCCTC intron-variant
rs4075774 -- 241,590,904(-) CTCTG(A/C/T)GTGTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for THAP4 Gene

Variant ID Type Subtype PubMed ID
nsv876226 CNV Loss 21882294
nsv834588 CNV Loss 17160897
dgv4493n71 CNV Loss 21882294
nsv876229 CNV Loss 21882294
dgv4494n71 CNV Loss 21882294
dgv4495n71 CNV Loss 21882294
dgv165e55 CNV Loss 17911159
esv21920 CNV Gain 19812545
esv2676442 CNV Deletion 23128226
esv2722011 CNV Deletion 23290073
esv1008655 CNV Deletion 20482838
dgv4496n71 CNV Loss 21882294
esv1033771 CNV Insertion 17803354
esv2662519 CNV Deletion 23128226
esv2722012 CNV Deletion 23290073
nsv508901 CNV Insertion 20534489
esv2722013 CNV Deletion 23290073

Relevant External Links for THAP4 Gene

HapMap Linkage Disequilibrium report
THAP4

Disorders for THAP4 Gene

Relevant External Links for THAP4

Genetic Association Database (GAD)
THAP4
genes like me logo Genes that share disorders with THAP4: view

No data available for UniProtKB/Swiss-Prot for THAP4 Gene

Publications for THAP4 Gene

  1. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PMID: 10810093) Lai C.-H. … Lin W.-C. (Genome Res. 2000) 2 3 4
  2. The THAP domain: a novel protein motif with similarity to the DNA-binding domain of P element transposase. (PMID: 12575992) Roussigne M. … Girard J.P. (Trends Biochem. Sci. 2003) 2 3
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Large-scale cDNA transfection screening for genes related to cancer development and progression. (PMID: 15498874) Wan D. … Gu J. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4

Products for THAP4 Gene

Sources for THAP4 Gene

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