Free for academic non-profit institutions. Other users need a Commercial license

Aliases for THAP4 Gene

Aliases for THAP4 Gene

  • THAP Domain Containing 4 2 3
  • CGI-36 3
  • PP238 3

External Ids for THAP4 Gene

Previous GeneCards Identifiers for THAP4 Gene

  • GC02M242543
  • GC02M242844
  • GC02M242243
  • GC02M234277

Summaries for THAP4 Gene

GeneCards Summary for THAP4 Gene

THAP4 (THAP Domain Containing 4) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding.

Gene Wiki entry for THAP4 Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for THAP4 Gene

Genomics for THAP4 Gene

Regulatory Elements for THAP4 Gene

Genomic Location for THAP4 Gene

Chromosome:
2
Start:
241,584,405 bp from pter
End:
241,637,525 bp from pter
Size:
53,121 bases
Orientation:
Minus strand

Genomic View for THAP4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for THAP4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for THAP4 Gene

Proteins for THAP4 Gene

  • Protein details for THAP4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WY91-THAP4_HUMAN
    Recommended name:
    THAP domain-containing protein 4
    Protein Accession:
    Q8WY91
    Secondary Accessions:
    • Q53NU7
    • Q6GRN0
    • Q6IPJ3
    • Q9NW26
    • Q9Y325

    Protein attributes for THAP4 Gene

    Size:
    577 amino acids
    Molecular mass:
    62890 Da
    Quaternary structure:
    • Homodimer.
    SequenceCaution:
    • Sequence=AAH00247.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH09439.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAA91560.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for THAP4 Gene

    Alternative splice isoforms for THAP4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for THAP4 Gene

Proteomics data for THAP4 Gene at MOPED

Post-translational modifications for THAP4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for THAP4 Gene

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for THAP4

No data available for DME Specific Peptides for THAP4 Gene

Domains & Families for THAP4 Gene

Gene Families for THAP4 Gene

Protein Domains for THAP4 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for THAP4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8WY91

UniProtKB/Swiss-Prot:

THAP4_HUMAN :
  • Contains 1 THAP-type zinc finger.
Similarity:
  • Contains 1 THAP-type zinc finger.
genes like me logo Genes that share domains with THAP4: view

Function for THAP4 Gene

Gene Ontology (GO) - Molecular Function for THAP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with THAP4: view

Phenotypes for THAP4 Gene

genes like me logo Genes that share phenotypes with THAP4: view

Animal Model Products

miRNA for THAP4 Gene

miRTarBase miRNAs that target THAP4

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for THAP4

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for THAP4 Gene

Localization for THAP4 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for THAP4 Gene COMPARTMENTS Subcellular localization image for THAP4 gene
Compartment Confidence
nucleus 3
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for THAP4 Gene

Pathways & Interactions for THAP4 Gene

SuperPathways for THAP4 Gene

No Data Available

Interacting Proteins for THAP4 Gene

Gene Ontology (GO) - Biological Process for THAP4 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for THAP4 Gene

Drugs & Compounds for THAP4 Gene

No Compound Related Data Available

Transcripts for THAP4 Gene

Unigene Clusters for THAP4 Gene

THAP domain containing 4:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for THAP4

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for THAP4 Gene

No ASD Table

Relevant External Links for THAP4 Gene

GeneLoc Exon Structure for
THAP4
ECgene alternative splicing isoforms for
THAP4

Expression for THAP4 Gene

mRNA expression in normal human tissues for THAP4 Gene

Protein differential expression in normal tissues from HIPED for THAP4 Gene

This gene is overexpressed in Tonsil (17.8), Skin (11.7), Heart (11.4), Salivary gland (7.2), and Oral epithelium (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for THAP4 Gene



SOURCE GeneReport for Unigene cluster for THAP4 Gene Hs.435759

genes like me logo Genes that share expression patterns with THAP4: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for THAP4 Gene

Orthologs for THAP4 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for THAP4 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia THAP4 35
  • 82.37 (n)
  • 80.43 (a)
THAP4 36
  • 80 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Thap4 35
  • 84.39 (n)
  • 84.98 (a)
Thap4 16
Thap4 36
  • 85 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia THAP4 35
  • 99.13 (n)
  • 99.31 (a)
THAP4 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Thap4 35
  • 83.95 (n)
  • 85.66 (a)
dog
(Canis familiaris)
Mammalia THAP4 36
  • 86 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia THAP4 36
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia THAP4 36
  • 71 (a)
OneToOne
chicken
(Gallus gallus)
Aves THAP4 35
  • 80.12 (n)
  • 88.3 (a)
THAP4 36
  • 71 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia THAP4 36
  • 68 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia thap4 35
  • 60.32 (n)
  • 60.63 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.33974 35
zebrafish
(Danio rerio)
Actinopterygii thap4 35
  • 64.63 (n)
  • 57.93 (a)
wufb76g01 35
thap4 36
  • 57 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6292 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003313 35
  • 55.84 (n)
  • 43.95 (a)
worm
(Caenorhabditis elegans)
Secernentea C52G5.2 36
  • 29 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G79260 35
  • 49.17 (n)
  • 40.62 (a)
rice
(Oryza sativa)
Liliopsida Os01g0679600 35
  • 52.81 (n)
  • 36.36 (a)
Species with no ortholog for THAP4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for THAP4 Gene

ENSEMBL:
Gene Tree for THAP4 (if available)
TreeFam:
Gene Tree for THAP4 (if available)

Paralogs for THAP4 Gene

No data available for Paralogs for THAP4 Gene

Variants for THAP4 Gene

Sequence variations from dbSNP and Humsavar for THAP4 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs3208142 -- 241,633,431(-) TCCTC(C/T)AAGCA synonymous-codon, reference
rs4072903 -- 241,597,717(+) CCTCA(A/G)TCCTG intron-variant
rs4072904 -- 241,598,291(-) GGCCC(C/T)GTGGG intron-variant
rs4072905 -- 241,598,277(-) TGGTC(A/G)GCCTC intron-variant
rs4075774 -- 241,590,904(-) CTCTG(A/C/T)GTGTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for THAP4 Gene

Variant ID Type Subtype PubMed ID
nsv876226 CNV Loss 21882294
nsv834588 CNV Loss 17160897
dgv4493n71 CNV Loss 21882294
nsv876229 CNV Loss 21882294
dgv4494n71 CNV Loss 21882294
dgv4495n71 CNV Loss 21882294
dgv165e55 CNV Loss 17911159
esv21920 CNV Gain 19812545
esv2676442 CNV Deletion 23128226
esv2722011 CNV Deletion 23290073
esv1008655 CNV Deletion 20482838
dgv4496n71 CNV Loss 21882294
esv1033771 CNV Insertion 17803354
esv2662519 CNV Deletion 23128226
esv2722012 CNV Deletion 23290073
nsv508901 CNV Insertion 20534489
esv2722013 CNV Deletion 23290073

Variation tolerance for THAP4 Gene

Residual Variation Intolerance Score: 35% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.23; 24.73% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for THAP4 Gene

HapMap Linkage Disequilibrium report
THAP4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for THAP4 Gene

Disorders for THAP4 Gene

Relevant External Links for THAP4

Genetic Association Database (GAD)
THAP4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
THAP4
genes like me logo Genes that share disorders with THAP4: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for THAP4 Gene

Publications for THAP4 Gene

  1. The THAP domain: a novel protein motif with similarity to the DNA-binding domain of P element transposase. (PMID: 12575992) Roussigne M. … Girard J.P. (Trends Biochem. Sci. 2003) 2 67
  2. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PMID: 10810093) Lai C.-H. … Lin W.-C. (Genome Res. 2000) 2 67
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  4. Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array. (PMID: 23535732) Eeles R.A. … Easton D.F. (Nat. Genet. 2013) 67
  5. Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition. (PMID: 22939624) Taipale M. … Lindquist S. (Cell 2012) 67

Products for THAP4 Gene

Sources for THAP4 Gene

Back to Top

Content