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Aliases for THAP4 Gene

Aliases for THAP4 Gene

  • THAP Domain Containing 4 2 3 5
  • THAP Domain-Containing Protein 4 3
  • CGI-36 3
  • PP238 3

External Ids for THAP4 Gene

Previous GeneCards Identifiers for THAP4 Gene

  • GC02M242543
  • GC02M242844
  • GC02M242243
  • GC02M234277

Summaries for THAP4 Gene

GeneCards Summary for THAP4 Gene

THAP4 (THAP Domain Containing 4) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is THAP5.

Gene Wiki entry for THAP4 Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for THAP4 Gene

Genomics for THAP4 Gene

Regulatory Elements for THAP4 Gene

Enhancers for THAP4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02F241635 1.1 ENCODE 11.5 -0.1 -78 4.0 PKNOX1 WRNIP1 ARID4B SIN3A DMAP1 YY1 ZNF143 ZNF207 SP3 SP5 BOK THAP4 ATG4B RNA5SP122 ING5 GC02M241661
GH02F241759 0.7 FANTOM5 1.3 -121.7 -121715 0.2 GATA3 PKNOX1 CUX1 EMSY MAFK TRIM28 D2HGDH PDCD1 ATG4B THAP4 ENSG00000234793 PIR37451
GH02F241641 1 Ensembl ENCODE 0.8 -4.5 -4476 0.8 SOX13 GATAD2A MXI1 SAP130 SP5 NR2F1 ARID4B THRB PPARG RAD21 D2HGDH ENSG00000234793 ING5 RNA5SP122 ENSG00000235351 THAP4 GC02M241661
GH02F241640 0.5 Ensembl 0.8 -3.5 -3476 0.8 SCRT1 LEF1 SCRT2 ATG4B THAP4 GC02M241661
GH02F241659 0.8 ENCODE 0.3 -22.0 -21956 0.2 CTCF SAP130 TEAD4 ARID4B CEBPG ZNF48 RAD21 TEAD3 GATAD1 ZNF143 ING5 D2HGDH ENSG00000234793 ANO7 GC02M241661 THAP4
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around THAP4 on UCSC Golden Path with GeneCards custom track

Promoters for THAP4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000610951 225 3401 PKNOX1 WRNIP1 ARID4B SIN3A DMAP1 YY1 ZNF143 ZNF207 SP3 SP5

Genomic Location for THAP4 Gene

Chromosome:
2
Start:
241,584,405 bp from pter
End:
241,637,525 bp from pter
Size:
53,121 bases
Orientation:
Minus strand

Genomic View for THAP4 Gene

Genes around THAP4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
THAP4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for THAP4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for THAP4 Gene

Proteins for THAP4 Gene

  • Protein details for THAP4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WY91-THAP4_HUMAN
    Recommended name:
    THAP domain-containing protein 4
    Protein Accession:
    Q8WY91
    Secondary Accessions:
    • Q53NU7
    • Q6GRN0
    • Q6IPJ3
    • Q9NW26
    • Q9Y325

    Protein attributes for THAP4 Gene

    Size:
    577 amino acids
    Molecular mass:
    62890 Da
    Quaternary structure:
    • Homodimer.
    SequenceCaution:
    • Sequence=AAH00247.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH09439.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAA91560.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for THAP4 Gene

    Alternative splice isoforms for THAP4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for THAP4 Gene

Post-translational modifications for THAP4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for THAP4 Gene

No data available for DME Specific Peptides for THAP4 Gene

Domains & Families for THAP4 Gene

Gene Families for THAP4 Gene

Protein Domains for THAP4 Gene

Suggested Antigen Peptide Sequences for THAP4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8WY91

UniProtKB/Swiss-Prot:

THAP4_HUMAN :
  • Contains 1 THAP-type zinc finger.
Similarity:
  • Contains 1 THAP-type zinc finger.
genes like me logo Genes that share domains with THAP4: view

Function for THAP4 Gene

Gene Ontology (GO) - Molecular Function for THAP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with THAP4: view
genes like me logo Genes that share phenotypes with THAP4: view

Animal Model Products

miRNA for THAP4 Gene

miRTarBase miRNAs that target THAP4

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for THAP4 Gene

Localization for THAP4 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for THAP4 gene
Compartment Confidence
nucleus 4
cytosol 3
extracellular 1
mitochondrion 1
endoplasmic reticulum 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for THAP4 Gene

Pathways & Interactions for THAP4 Gene

SuperPathways for THAP4 Gene

No Data Available

Interacting Proteins for THAP4 Gene

Gene Ontology (GO) - Biological Process for THAP4 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for THAP4 Gene

Transcripts for THAP4 Gene

Unigene Clusters for THAP4 Gene

THAP domain containing 4:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for THAP4 Gene

No ASD Table

Relevant External Links for THAP4 Gene

GeneLoc Exon Structure for
THAP4
ECgene alternative splicing isoforms for
THAP4

Expression for THAP4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for THAP4 Gene

Protein differential expression in normal tissues from HIPED for THAP4 Gene

This gene is overexpressed in Tonsil (17.8), Skin (11.7), Heart (11.4), Salivary gland (7.2), and Oral epithelium (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for THAP4 Gene



NURSA nuclear receptor signaling pathways regulating expression of THAP4 Gene:

THAP4

SOURCE GeneReport for Unigene cluster for THAP4 Gene:

Hs.435759
genes like me logo Genes that share expression patterns with THAP4: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for THAP4 Gene

Orthologs for THAP4 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for THAP4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia THAP4 34 35
  • 99.13 (n)
dog
(Canis familiaris)
Mammalia THAP4 35
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Thap4 34 16 35
  • 84.39 (n)
rat
(Rattus norvegicus)
Mammalia Thap4 34
  • 83.95 (n)
oppossum
(Monodelphis domestica)
Mammalia THAP4 35
  • 83 (a)
OneToOne
cow
(Bos Taurus)
Mammalia THAP4 34 35
  • 82.37 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia THAP4 35
  • 71 (a)
OneToOne
chicken
(Gallus gallus)
Aves THAP4 34 35
  • 80.12 (n)
lizard
(Anolis carolinensis)
Reptilia THAP4 35
  • 68 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia thap4 34
  • 60.32 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.33974 34
zebrafish
(Danio rerio)
Actinopterygii thap4 34 35
  • 64.63 (n)
wufb76g01 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6292 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003313 34
  • 55.84 (n)
worm
(Caenorhabditis elegans)
Secernentea C52G5.2 35
  • 29 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G79260 34
  • 49.17 (n)
rice
(Oryza sativa)
Liliopsida Os01g0679600 34
  • 52.81 (n)
Species where no ortholog for THAP4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for THAP4 Gene

ENSEMBL:
Gene Tree for THAP4 (if available)
TreeFam:
Gene Tree for THAP4 (if available)

Paralogs for THAP4 Gene

Paralogs for THAP4 Gene

genes like me logo Genes that share paralogs with THAP4: view

Variants for THAP4 Gene

Sequence variations from dbSNP and Humsavar for THAP4 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs111162963 -- 241,620,304(+) GAGTC(A/G)TGAGT intron-variant
rs111162964 -- 241,620,380(+) GAGGG(G/T)TGAGT intron-variant
rs111162965 -- 241,620,425(+) TGAGG(C/G)GTGAG intron-variant
rs111162966 -- 241,620,433(+) GAGGG(G/T)TGAGT intron-variant
rs111214888 -- 241,620,140(+) TGAGG(C/G)GTGAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for THAP4 Gene

Variant ID Type Subtype PubMed ID
nsv956705 CNV deletion 24416366
nsv834588 CNV loss 17160897
nsv584974 CNV gain 21841781
nsv584970 CNV loss 21841781
nsv508901 CNV insertion 20534489
nsv1133496 CNV deletion 24896259
nsv1118902 CNV deletion 24896259
nsv1116839 CNV deletion 24896259
esv3561312 CNV deletion 23714750
esv2722013 CNV deletion 23290073
esv2722012 CNV deletion 23290073
esv2722011 CNV deletion 23290073
esv2676442 CNV deletion 23128226
esv2662519 CNV deletion 23128226
esv21920 CNV gain 19812545
esv1033771 CNV insertion 17803354
esv1008655 CNV deletion 20482838
dgv2379e59 CNV duplication 20981092
dgv165e55 CNV loss 17911159

Variation tolerance for THAP4 Gene

Residual Variation Intolerance Score: 35% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.23; 24.73% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for THAP4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
THAP4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for THAP4 Gene

Disorders for THAP4 Gene

Relevant External Links for THAP4

Genetic Association Database (GAD)
THAP4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
THAP4

No disorders were found for THAP4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for THAP4 Gene

Publications for THAP4 Gene

  1. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PMID: 10810093) Lai C.-H. … Lin W.-C. (Genome Res. 2000) 2 3 4 64
  2. Voxelwise genome-wide association study (vGWAS). (PMID: 20171287) Stein J.L. … Thompson P. (Neuroimage 2010) 3 46 64
  3. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 3 4 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for THAP4 Gene

Sources for THAP4 Gene

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