THAP4 Gene
protein-coding GIFtS: 47
GCID: GC02M242543
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THAP domain containing 4
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Aliases
for THAP4 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| THAP Domain Containing 41 2 | | CGI-361 | | PP2382 | | THAP Domain-Containing Protein 42 |
Export aliases for THAP4 gene to outside databasesPrevious GC identifers: GC02M242844 GC02M242243 GC02M234277 |
Summaries
for THAP4 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Gene Wiki entry for THAP4
|
Genomic Views
for THAP4 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000002.11 NC_018913.1 NT_005416.13
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the THAP4 gene promoter:
Tal-1 Pax-6 E47 YY1 GATA-1 MEF-2A E2F-1 E2F HOXA5 aMEF-2
Other transcription factors
Search SABiosciences Chromatin IP Primers for THAP4
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat THAP4 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 2q37.3 Ensembl cytogenetic band: 2q37.3 HGNC cytogenetic band: 2q37.3THAP4 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 2 GeneLoc Exon Structure GeneLoc location for GC02M242543: view genomic region
(about GC identifiers)
Start:
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242,523,820 bp from pter |
End:
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242,576,864 bp from pter |
Size:
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53,045 bases |
Orientation:
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minus strand |
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Proteins
for THAP4 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: THAP4_HUMAN, Q8WY91 (See
protein sequence)Recommended Name: THAP domain-containing protein 4 Size: 577 amino acids; 62890 Da
Subunit: Homodimer (Probable)
Sequence caution: Sequence=AAH00247.1; Type=Erroneous initiation; Note=Translation N-terminally extended;Sequence=AAH09439.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAA91560.1;Type=Erroneous initiation; Note=Translation N-terminally extended;
1 PDB 3D structure from  and Proteopedia  for THAP4:3IA8 (3D)
Secondary accessions: Q53NU7 Q6GRN0 Q6IPJ3 Q9NW26 Q9Y325Alternative splicing: 2 isoforms: Q8WY91-1 Q8WY91-2 Explore the universe of human proteins at neXtProt for THAP4: NX_Q8WY91
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8WY91
THAP4 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001157828.1 NP_057047.4
ENSEMBL proteins: ENSP00000385931 ENSP00000385006 ENSP00000384352
Human Recombinant Protein Products:
THAP4 Antibody Products:
Assay Products for THAP4: |
Protein
Domains /
Families
for THAP4 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
THAP4 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q8WY91ProtoNet protein and cluster: Q8WY91 UniProtKB/Swiss-Prot: THAP4_HUMAN, Q8WY91Similarity: Contains 1 THAP-type zinc finger |
Function
for THAP4 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for THAP4 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for THAP4 (see all 4)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): THAP4 (NM_015963) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for THAP4 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat THAP4 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for THAP4 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003677 | DNA binding |
IEA | -- | | GO:0046872 | metal ion binding |
IEA | -- |
THAP4 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for THAP4:
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Pathways & Interactions
for THAP4 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for THAP4
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
3 Interacting proteins for THAP4 (Q8WY912, 3 ENSP000003850064) via UniProtKB, MINT, STRING, and/or I2DAbout this table
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Drugs & Compounds
for THAP4 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for THAP4
Search CenterWatch for drugs/clinical trials and news about THAP4
|
Transcripts
for THAP4 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for THAP4 gene (2 alternative transcripts): NM_001164356.1 NM_015963.5 Unigene Cluster for THAP4: THAP domain containing 4 Hs.435759 [show with all ESTs]Unigene Representative Sequence: NM_0159635 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000402136(uc002wbs.3) ENST00000407315(uc002wbt.3) ENST00000321679
ENST00000402545 ENST00000497486
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for THAP4 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for THAP4 (see all 4)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): THAP4 (NM_015963) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for THAP4 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat THAP4 |
Additional cDNA sequence: AF132970.1 AF258556.1 AK001216.1 AK225608.1 BC000247.1 BC000767.2 BC001842.2 BC009439.1 BC069235.1 BC071896.1 BC094822.1 15 DOTS entries: DT.86821254 DT.92444131 DT.120930212 DT.100806180 DT.95353131 DT.97847270 DT.218136 DT.92444139 DT.95353139 DT.95363915 DT.120930114 DT.92444132 DT.95353184 DT.100662509 DT.429722 24/335 AceView cDNA sequences (see all 335): BM142680 BC000247 BU734321 BQ960363 BE622038 AK001216 BF345934 BM314497 BG287108 BU165299 NM_015963 AI570785 F27156 BC071896 BM976133 BU683013 BE858768 BF528421 BC001842 AI961301 BQ942495 BE222615 BM471597 BU782671
GeneLoc Exon Structure
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Expression
for THAP4 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| THAP4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCAACCACGA
About this image
See THAP4 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for THAP4
SOURCE GeneReport for Unigene cluster: Hs.435759
SABiosciences Custom PCR Arrays for THAP4
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for THAP4
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat THAP4 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat THAP4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat THAP4 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for THAP4 |
Orthologs
for THAP4 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for THAP4 gene from 9/20 species (see all 20) About this table
ENSEMBL Gene Tree for THAP4 (if available)
TreeFam Gene Tree for THAP4 (if available) |
Paralogs
for THAP4 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for THAP4 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 2 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for THAP4 (242523820 - 242576864 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 5 variations for THAP4
5 CNVs: 34635 4331 68300 8969 23608 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing THAP4 |
|
Disorders
/ Diseases
for THAP4 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
THAP4 for disorders About GeneDecksing
OMIM gene information: 612533
OMIM disorders: --
2  diseases for THAP4: About MalaCardstuberculosis mycobacterium tuberculosis
Export disorders for THAP4 gene to outside databases
|
Publications
for THAP4 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for THAP4 gene, integrated from 9 sources (see all 14):
(articles sorted by number of sources associating them with THAP4) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PubMed id 10810093)1, 2, 3 Lai C.H....Lin W. (2000)
- Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W....Wilson R.K. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Large-scale cDNA transfection screening for genes related to cancer development and progression. (PubMed id 15498874)1, 2 Wan D....Gu J. (2004)
- The THAP domain: a novel protein motif with similarity to the DNA-binding domain of P element transposase. (PubMed id 12575992)1, 3 Roussigne M....Girard J.P. (2003)
- Structure of the C-terminal heme-binding domain of THAP domain containing protein 4 from Homo sapiens. (PubMed id 21387410)2 Bianchetti C.M.... Phillips G.N. Jr. (2011)
- Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
- A directed protein interaction network for investigat ing intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (2011)
- Voxelwise genome-wide association study (vGWAS). (PubMed id 20171287)1 Stein J.L....Thompson P. (2010)
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External Searches for THAP4 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing THAP4 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing THAP4 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing THAP4 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for THAP4 | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for THAP4 gene:
Search GeneIP for patents involving THAP4
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for THAP4 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for THAP4 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for THAP4 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for THAP4 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for THAP4 | | OriGene 3'-UTR Clone for THAP4 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for THAP4 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for THAP4 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for THAP4 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for THAP4 | | OriGene Custom Protein Services for THAP4 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat THAP4 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing THAP4 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat THAP4 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat THAP4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat THAP4 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat THAP4 |
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| | | | Search Tocris compounds for THAP4 |
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 | | | THAP4 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for THAP4 |
|  |  |  | | | | ThermoFisher Antibody for THAP4 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat THAP4 |
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