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THAP3 Gene

protein-coding   GIFtS: 48
GCID: GC01P006684

THAP Domain Containing, Apoptosis Associated Protein 3

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
THAP Domain Containing, Apoptosis Associated Protein 31 2
THAP Domain-Containing Protein 32

External Ids:    HGNC: 208551   Entrez Gene: 903262   Ensembl: ENSG000000419887   OMIM: 6125325   UniProtKB: Q8WTV13   

Export aliases for THAP3 gene to outside databases

Previous GC identifers: GC00U909480 GC01P006620 GC01P006609 GC01P005832


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for THAP3 Gene:
THAP3 (THAP domain containing, apoptosis associated protein 3) is a protein-coding gene. An important paralog of this gene is THAP1.

UniProtKB/Swiss-Prot: THAP3_HUMAN, Q8WTV1
Function: Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional
activity of RRM1




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the THAP3 gene promoter:
         Spz1   AML1a   MIF-1   Ik-3   E47   GATA-1   C/EBPalpha   CHOP-10   PPAR-gamma1   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTHAP3 promoter sequence
   Search Chromatin IP Primers for THAP3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat THAP3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.31   Ensembl cytogenetic band:  1p36.31   HGNC cytogenetic band: 1p36.1

THAP3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
THAP3 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P006684:  view genomic region     (about GC identifiers)

Start:
6,684,925 bp from pter      End:
6,695,646 bp from pter
Size:
10,722 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: THAP3_HUMAN, Q8WTV1 (See protein sequence)
Recommended Name: THAP domain-containing protein 3  
Size: 239 amino acids; 27059 Da
Subunit: Component of a THAP1/THAP3-HCFC1-OGT complex that contains at least, either THAP1 or THAP3, HCFC1 and
OGT. Interacts directly with OGT and HCFC1 (via its HBM)
Secondary accessions: Q569K1 Q5TH66 Q5TH67 Q8N8T6 Q9BSC7 Q9Y3H2 Q9Y3H3
Alternative splicing: 3 isoforms:  Q8WTV1-1   Q8WTV1-3   Q8WTV1-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for THAP3: NX_Q8WTV1

Explore proteomics data for THAP3 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See THAP3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001182681.1  NP_001182682.1  NP_612359.2  

    ENSEMBL proteins: 
     ENSP00000054650   ENSP00000311537   ENSP00000366854   ENSP00000464954   ENSP00000473646  

    THAP3 Human Recombinant Protein Products:

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    ProSpec Recombinant Protein for THAP3
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    Search eBioscience for ELISAs for THAP3 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    THAP: THAP (C2CH-type zinc finger) domain containing

    2 InterPro protein domains:
     IPR006612 Znf_C2CH
     IPR026520 THAP3

    Graphical View of Domain Structure for InterPro Entry Q8WTV1

    ProtoNet protein and cluster: Q8WTV1

    UniProtKB/Swiss-Prot: THAP3_HUMAN, Q8WTV1
    Similarity: Contains 1 THAP-type zinc finger


    Find genes that share domains with THAP3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: THAP3_HUMAN, Q8WTV1
    Function: Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional
    activity of RRM1

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0005515protein binding IPI--
    GO:0046872metal ion binding IEA--
         
    Find genes that share ontologies with THAP3           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for THAP3:
     Decreased p24 protein expressi  Increased S DNA content  Increased cell number in G2M,  

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for THAP3
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for THAP3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for THAP3

    miRNA
    Products:
        
    miRTarBase miRNAs that target THAP3:
    hsa-mir-125b-5p (MIRT045903), hsa-mir-26b-5p (MIRT029166), hsa-mir-335-5p (MIRT017413)

    Block miRNA regulation of human, mouse, rat THAP3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate THAP3 (see all 19):
    hsa-miR-4254 hsa-miR-3200-5p hsa-miR-4251 hsa-miR-146a hsa-miR-340 hsa-miR-548a-3p hsa-miR-124 hsa-miR-3154
    SwitchGear 3'UTR luciferase reporter plasmidTHAP3 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat THAP3

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for THAP3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    extracellular2
    cytosol1
    mitochondrion1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for THAP3
    Interactions:

        Search GeneGlobe Interaction Network for THAP3

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    3 Interacting proteins for THAP3 (Q8WTV13 ENSP000003668544) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HCFC1P516103, ENSP000003095554I2D: score=1 STRING: ENSP00000309555
    OGTO152943, ENSP000003628244I2D: score=1 STRING: ENSP00000362824
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for THAP3



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for THAP3 gene (3 alternative transcripts): 
    NM_001195752.1  NM_001195753.1  NM_138350.3  

    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000054650(uc001aoc.3 uc001aod.3) ENST00000484676 ENST00000307896
    ENST00000377627(uc001aoe.2) ENST00000484669 ENST00000487819 ENST00000472925
    ENST00000480647
    miRNA
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    Block miRNA regulation of human, mouse, rat THAP3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate THAP3 (see all 19):
    hsa-miR-4254 hsa-miR-3200-5p hsa-miR-4251 hsa-miR-146a hsa-miR-340 hsa-miR-548a-3p hsa-miR-124 hsa-miR-3154
    SwitchGear 3'UTR luciferase reporter plasmidTHAP3 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for THAP3
    Predesigned siRNA for gene silencing in human, mouse, rat THAP3
    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 3): THAP3 (NM_138350)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat THAP3
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for THAP3
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      QuantiTect SYBR Green Assays in human, mouse, rat THAP3
      QuantiFast Probe-based Assays in human, mouse, rat THAP3

    Selected AceView cDNA sequences (see all 125):

    BQ681499 CR609298 BU857326 BU684782 CR601567 CD245750 BU190263 AA235985 
    Z41901 CA425222 BM687067 BM126658 BF448596 BU527489 CR600561 BE220041 
    CR600833 AF086370 AI365345 BM675516 BQ056118 CR620139 AW590484 AI984347 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for THAP3    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7
    SP1:        -     -                       -                     
    SP2:        -     -                                   -         
    SP3:        -     -                       -                     
    SP4:                                                            
    SP5:                                                            


    ECgene alternative splicing isoforms for THAP3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    THAP3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGAGGGGGCT
    THAP3 Expression
    About this image


    THAP3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Limb (Muscoskeletal System)
             Limb Bud Mesenchyme Cells Limb Bud
     
     Mesoderm (Gastrulation Derivatives)
             Limb Bud Mesenchyme Cells Limb Bud
    THAP3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    THAP3 Protein Expression

    UniProtKB/Swiss-Prot: THAP3_HUMAN, Q8WTV1
    Tissue specificity: Highly expressed in heart, skeletal muscle and placenta. Weaker expression in brain, kidney
    and liver

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for THAP3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for THAP3 gene from Selected species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Thap31 , 5 THAP domain containing, apoptosis associated protein 3 less1, 5 80.54(n)1
    78.95(a)1
      4 (82.80 cM)5
    698761  NM_175152.41  NP_780361.21 
     1519826395 
    zebrafish
    (Danio rerio)
    Actinopterygii thap31 THAP domain containing, apoptosis associated protein 3 less 50(n)
    46.87(a)
      541481  NM_001014294.1  NP_001014316.1 


    ENSEMBL Gene Tree for THAP3 (if available)
    TreeFam Gene Tree for THAP3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for THAP3 gene
    THAP12  ENSG000002580642  THAP22  THAP52  THAP82  
    3 SIMAP similar genes for THAP3 using alignment to 3 protein entries:     THAP3_HUMAN (see all proteins):
    THAP1    THAP9    THAP6

    Find genes that share paralogs with THAP3           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for THAP3
    PGOHUM00000244826


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for THAP3 (see all 202)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1890852211,2
    --6684760(+) TGCCTC/TTTCAC 3 -- us2k10--------
    rs20763631,2
    C,F,A,H--6684906(-) CCTCAG/CTGTTT 3 -- us2k117Minor allele frequency- C:0.29NS EA NA WA CSA 1145
    rs1123669511,2
    C,F--6684923(+) CCGTTG/AGTTTC 3 -- us2k12Minor allele frequency- A:0.04CSA WA 119
    rs2016308581,2
    C--6685050(+) TGGGG-/TTTTCG 3 -- us2k1 int10--------
    rs1430849751,2
    --6685416(+) CCGAGC/GCCTTG 3 -- int10--------
    rs127465911,2
    C,F,A--6685442(+) GGCCCG/AAAGGC 3 -- int15Minor allele frequency- A:0.37NA WA EA 128
    rs127241671,2
    F,H--6685595(+) GCGGAA/G/TCAGGT 3 -- int14NS EA 416
    rs1398325211,2
    --6685596(+) CGGAGA/CAGGTG 3 -- int10--------
    rs121271911,2
    C,F,A--6685774(+) GAGGAC/TGCTGG 3 -- int18Minor allele frequency- T:0.38NA WA CSA EA 367
    rs1998053521,2
    C--6685825(-) TGGGCC/TGNNNN 3 -- int10--------

    HapMap Linkage Disequilibrium report for THAP3 (6684925 - 6695646 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for THAP3:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv129n71CNV Loss21882294
    dgv130n71CNV Loss21882294
    nsv826253CNV Gain20364138
    nsv871348CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 612532    OMIM disorders: --


    Find genes that share disorders with THAP3           About GenesLikeMe

    Genetic Association Database (GAD): THAP3
    Human Genome Epidemiology (HuGE) Navigator: THAP3 (1 document)

    Export disorders for THAP3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for THAP3 gene, integrated from 10 sources (see all 11):
    (articles sorted by number of sources associating them with THAP3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The THAP-zinc finger protein THAP1 associates with coactivator HCF-1 and O-GlcNAc transferase: a link between DYT6 and DYT3 dystonias. (PubMed id 20200153)1, 2 Mazars R.... Girard J.P. (J. Biol. Chem. 2010)
    2. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. The THAP domain: a novel protein motif with similarity to the DNA-binding domain of P element transposase. (PubMed id 12575992)1, 3 Roussigne M....Girard J.P. (Trends Biochem. Sci. 2003)
    6. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    7. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (J. Biol. Chem. 2011)
    8. Genetic associations of variants in genes encoding HIV-dependency factors required for HIV-1 infection. (PubMed id 21083371)4 Chinn L.W....O'Brien S.J. (J. Infect. Dis. 2010)
    9. Identification of host proteins required for HIV infection through a functional genomic screen. (PubMed id 18187620)1 Brass A.L....Elledge S.J. (Science 2008)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 90326 HGNC: 20855 AceView: MGC33488 Ensembl:ENSG00000041988 euGenes: HUgn90326
    ECgene: THAP3 H-InvDB: THAP3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for THAP3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for THAP3 gene:
    Search GeneIP for patents involving THAP3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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