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Aliases for THAP3 Gene

Aliases for THAP3 Gene

  • THAP Domain Containing, Apoptosis Associated Protein 3 2 3

External Ids for THAP3 Gene

Previous GeneCards Identifiers for THAP3 Gene

  • GC00U909480
  • GC01P006620
  • GC01P006609
  • GC01P006684
  • GC01P005832
  • GC01P006626

Summaries for THAP3 Gene

GeneCards Summary for THAP3 Gene

THAP3 (THAP Domain Containing, Apoptosis Associated Protein 3) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is THAP8.

UniProtKB/Swiss-Prot for THAP3 Gene

  • Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for THAP3 Gene

Genomics for THAP3 Gene

Regulatory Elements for THAP3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for THAP3 Gene

6,624,865 bp from pter
6,635,586 bp from pter
10,722 bases
Plus strand

Genomic View for THAP3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for THAP3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for THAP3 Gene

Proteins for THAP3 Gene

  • Protein details for THAP3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    THAP domain-containing protein 3
    Protein Accession:
    Secondary Accessions:
    • Q569K1
    • Q5TH66
    • Q5TH67
    • Q8N8T6
    • Q9BSC7
    • Q9Y3H2
    • Q9Y3H3

    Protein attributes for THAP3 Gene

    239 amino acids
    Molecular mass:
    27059 Da
    Quaternary structure:
    • Component of a THAP1/THAP3-HCFC1-OGT complex that contains at least, either THAP1 or THAP3, HCFC1 and OGT. Interacts directly with OGT and HCFC1 (via its HBM).

    Alternative splice isoforms for THAP3 Gene


neXtProt entry for THAP3 Gene

Proteomics data for THAP3 Gene at MOPED

Post-translational modifications for THAP3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for THAP3 Gene

No data available for DME Specific Peptides for THAP3 Gene

Domains & Families for THAP3 Gene

Gene Families for THAP3 Gene

Protein Domains for THAP3 Gene


Suggested Antigen Peptide Sequences for THAP3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 THAP-type zinc finger.
  • Contains 1 THAP-type zinc finger.
genes like me logo Genes that share domains with THAP3: view

Function for THAP3 Gene

Molecular function for THAP3 Gene

UniProtKB/Swiss-Prot Function:
Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1.

Gene Ontology (GO) - Molecular Function for THAP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 20200153
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with THAP3: view
genes like me logo Genes that share phenotypes with THAP3: view

Animal Model Products

miRNA for THAP3 Gene

miRTarBase miRNAs that target THAP3

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for THAP3

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for THAP3 Gene

Localization for THAP3 Gene

Subcellular locations from

Jensen Localization Image for THAP3 Gene COMPARTMENTS Subcellular localization image for THAP3 gene
Compartment Confidence
cytosol 2
nucleus 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for THAP3 Gene

Pathways & Interactions for THAP3 Gene

SuperPathways for THAP3 Gene

No Data Available

Interacting Proteins for THAP3 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
Selected Interacting proteins: Q8WTV1-THAP3_HUMAN ENSP00000054650 for THAP3 Gene via I2D STRING

Gene Ontology (GO) - Biological Process for THAP3 Gene


No data available for Pathways by source and SIGNOR curated interactions for THAP3 Gene

Drugs & Compounds for THAP3 Gene

No Compound Related Data Available

Transcripts for THAP3 Gene

Unigene Clusters for THAP3 Gene

THAP domain containing, apoptosis associated protein 3:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for THAP3

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for THAP3 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7
SP1: - - -
SP2: - - -
SP3: - - -

Relevant External Links for THAP3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for THAP3 Gene

mRNA expression in normal human tissues for THAP3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for THAP3 Gene

This gene is overexpressed in Placenta (66.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for THAP3 Gene

SOURCE GeneReport for Unigene cluster for THAP3 Gene Hs.689006

mRNA Expression by UniProt/SwissProt for THAP3 Gene

Tissue specificity: Highly expressed in heart, skeletal muscle and placenta. Weaker expression in brain, kidney and liver.
genes like me logo Genes that share expression patterns with THAP3: view

Protein tissue co-expression partners for THAP3 Gene

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for THAP3 Gene

Orthologs for THAP3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for THAP3 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia THAP3 35
  • 82.49 (n)
  • 74.37 (a)
THAP3 36
  • 74 (a)
(Canis familiaris)
Mammalia THAP3 35
  • 80.97 (n)
  • 75.47 (a)
THAP3 36
  • 75 (a)
(Mus musculus)
Mammalia Thap3 35
  • 80.54 (n)
  • 78.95 (a)
Thap3 16
Thap3 36
  • 77 (a)
(Pan troglodytes)
Mammalia THAP3 35
  • 99.16 (n)
  • 98.74 (a)
THAP3 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Thap3 35
  • 80.09 (n)
  • 77.73 (a)
(Monodelphis domestica)
Mammalia THAP3 36
  • 66 (a)
(Ornithorhynchus anatinus)
Mammalia THAP3 36
  • 59 (a)
(Danio rerio)
Actinopterygii thap3 35
  • 50 (n)
  • 46.87 (a)
thap3 36
  • 37 (a)
Species with no ortholog for THAP3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for THAP3 Gene

Gene Tree for THAP3 (if available)
Gene Tree for THAP3 (if available)

Paralogs for THAP3 Gene

Paralogs for THAP3 Gene

(3) SIMAP similar genes for THAP3 Gene using alignment to 3 proteins: Pseudogenes for THAP3 Gene

genes like me logo Genes that share paralogs with THAP3: view

Variants for THAP3 Gene

Sequence variations from dbSNP and Humsavar for THAP3 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs182123 -- 6,632,236(-) CCCTG(G/T)AACTG intron-variant
rs742394 -- 6,630,080(-) AATCA(C/T)GGTCA intron-variant
rs1556034 -- 6,629,259(+) CCCAC(A/G)TGGAG intron-variant
rs1974075 -- 6,629,117(+) GAATC(G/T)CTTGA intron-variant
rs2076363 -- 6,624,846(-) CCTCA(C/G)TGTTT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for THAP3 Gene

Variant ID Type Subtype PubMed ID
dgv129n71 CNV Loss 21882294
nsv871348 CNV Gain 21882294
dgv130n71 CNV Loss 21882294
nsv826253 CNV Gain 20364138

Variation tolerance for THAP3 Gene

Residual Variation Intolerance Score: 76.89% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.46; 43.27% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for THAP3 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for THAP3 Gene

Disorders for THAP3 Gene

Relevant External Links for THAP3

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with THAP3: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for THAP3 Gene

Publications for THAP3 Gene

  1. The THAP domain: a novel protein motif with similarity to the DNA-binding domain of P element transposase. (PMID: 12575992) Roussigne M. … Girard J.P. (Trends Biochem. Sci. 2003) 2 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  3. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 67
  4. The THAP-zinc finger protein THAP1 associates with coactivator HCF-1 and O-GlcNAc transferase: a link between DYT6 and DYT3 dystonias. (PMID: 20200153) Mazars R. … Girard J.P. (J. Biol. Chem. 2010) 67
  5. Genetic associations of variants in genes encoding HIV-dependency factors required for HIV-1 infection. (PMID: 21083371) Chinn L.W. … O'Brien S.J. (J. Infect. Dis. 2010) 67

Products for THAP3 Gene

Sources for THAP3 Gene

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