THAP3 Gene
protein-coding GIFtS : 47
GCID: GC01 P006684
THAP domain containing, apoptosis associated protein 3
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Aliasesfor THAP3 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases THAP Domain Containing, Apoptosis Associated Protein 3 1 2 THAP Domain-Containing Protein 32
Export aliases for THAP3 gene to outside databases Previous GC identifers: GC00U909480 GC01P006620 GC01P006609 GC01P005832
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Summariesfor THAP3 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section UniProtKB/Swiss-Prot: THAP3_HUMAN, Q8WTV1 Function : Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptionalactivity of RRM1
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Genomic Viewsfor THAP3 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000001.10 NC_018912.1 NT_021937.19 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the THAP3 gene promoter: Spz1 AML1a MIF-1 Ik-3 E47 GATA-1 C/EBPalpha CHOP-10 PPAR-gamma1 PPAR-gamma2 Other transcription factors Search SABiosciences Chromatin IP Primers for THAP3 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat THAP3
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 1p36.31 Ensembl cytogenetic band: 1p36.31 HGNC cytogenetic band: 1p36.1 THAP3 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 1 GeneLoc Exon Structure
GeneLoc location for GC01P006684: view genomic region
(about GC identifiers )
Start:
6,684,926 bp from pter
End:
6,695,646 bp from pter
Size:
10,721 bases
Orientation:
plus strand
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Proteinsfor THAP3 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: THAP3_HUMAN, Q8WTV1 (See
protein sequence )Recommended Name: THAP domain-containing protein 3 Size : 239 amino acids; 27059 Da
Subunit : Component of a THAP1/THAP3-HCFC1-OGT complex that contains at least, either THAP1 or THAP3, HCFC1 and OGT.Interacts directly with OGT and HCFC1 (via its HBM)
Secondary accessions : Q569K1 Q5TH66 Q5TH67 Q8N8T6 Q9BSC7 Q9Y3H2 Q9Y3H3Alternative splicing : 3 isoforms : Q8WTV1-1 Q8WTV1-3 Q8WTV1-4 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for THAP3: NX_Q8WTV1 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q8WTV1 THAP3 Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins (3 alternative transcripts):
NP_001182681.1 NP_001182682.1 NP_612359.2 ENSEMBL proteins: ENSP00000054650 ENSP00000311537 ENSP00000366854 ENSP00000465768 ENSP00000464954 Human Recombinant Protein Products: THAP3 Antibody Products: Assay Products for THAP3:
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Protein
Domains / Familiesfor THAP3 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
THAP3 for domains About GeneDecksing 2 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry Q8WTV1 ProtoNet protein and cluster: Q8WTV1
UniProtKB/Swiss-Prot: THAP3_HUMAN, Q8WTV1 Similarity : Contains 1 THAP-type zinc finger
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Functionfor THAP3 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Function Summary: UniProtKB/Swiss-Prot: THAP3_HUMAN, Q8WTV1 Function : Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptionalactivity of RRM1
Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for THAP3 (see all 6 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for THAP3OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector (see all 3 ): THAP3 (NM_138350 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for THAP3 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat THAP3
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for THAP3
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view) : About this table
THAP3 for ontologies About GeneDecksing 3 GenomeRNAi human phenotypes for THAP3 :
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Pathways & Interactionsfor THAP3 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for THAP3 STRING Interaction
Network Preview (showing 3 interactants - click image to see more details)3 Interacting proteins for THAP3 (Q8WTV1 3 ENSP00000366854 4 ) via UniProtKB, MINT, STRING , and/or I2D About this table
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Drugs & Compoundsfor THAP3 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for THAP3 Search CenterWatch for drugs/clinical trials and news about THAP3
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Transcriptsfor THAP3 gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for THAP3 gene (3 alternative transcripts): NM_001195752.1 NM_001195753.1 NM_138350.3 Unigene Cluster for THAP3:
THAP domain containing, apoptosis associated protein 3 Hs.689006 [show with all ESTs ] Unigene Representative Sequence: NM_138350 8 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000054650 (uc001aoc.3 uc001aod.3 ) ENST00000484676 ENST00000307896 ENST00000377627 (uc001aoe.2 ) ENST00000484669 ENST00000487819 ENST00000472925 ENST00000480647 Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for THAP3 (see all 6 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for THAP3OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector (see all 3 ): THAP3 (NM_138350 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for THAP3 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat THAP3
Additional cDNA sequence: AF086370.1 AK096217.1 BC005114.1 BC022081.2 BC092427.1
13 DOTS entries : DT.447625 DT.100653629
DT.99985402 DT.445231 DT.100758642 DT.91748007 DT.100795639 DT.92051561 DT.121331028 DT.75102383 DT.102832603 DT.40301323 DT.95322862 24/125 AceView cDNA sequences (see all 125 ):
BF448596 BX088984 BQ065768 BU857326 BU527489 CR620139 AI984347 BM687067 Z41901 AA235985 CR600833 BU190263 BM126658 BQ023670 BM675516 BE672540 AI967965 CA425222 CR609298 CR600561 BM691509 BQ681499 AW590484 AW269168 GeneLoc Exon Structure 5 Alternative Splicing Database (ASD) splice patterns (SP) for THAP3 About this scheme ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 SP1 :   -   -         -         SP2 :   -   -             -     SP3 :   -   -         -         SP4 :                     SP5 :                    
ECgene alternative splicing isoforms for THAP3
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Expression for THAP3 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section THAP3 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: TGAGGGGGCT
About this image THAP3 expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table 1 LifeMap In Vivo Development Anatomical Compartment/Cell Tissue Anatomical Compartment
Cell Category (developmental path) Limb Limb Bud Limb Bud Mesenchyme Cells Mesoderm Expression: Positive Negative
Selective markerExperimental details:
Curated
Microarrays
In-situ hybridization
See THAP3 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for THAP3 SOURCE GeneReport for Unigene cluster: Hs.689006 UniProtKB/Swiss-Prot: THAP3_HUMAN, Q8WTV1 Tissue specificity : Highly expressed in heart, skeletal muscle and placenta. Weaker expression in brain, kidney andliver SABiosciences Custom PCR Arrays for THAP3 Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for THAP3Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse / rat THAP3 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat THAP3 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat THAP3 In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for THAP3
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Orthologsfor THAP3 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of chordates.
Orthologs for THAP3 gene from 1/8 species (see all 8 ) About this table
Organism
Taxonomic classification
Gene
Description
Human Similarity
Orthology Type
Details
zebrafish (Danio rerio)
Actinopterygii
thap31
THAP domain containing, apoptosis associated protein 3 less
50(n) 46.87(a)
 
541481 NM_001014294.1 NP_001014316.1
ENSEMBL Gene Tree for THAP3 (if available)TreeFam Gene Tree for THAP3 (if available)
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Paralogsfor THAP3 gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for THAP3 gene THAP1 2 ENSG00000258064 2 THAP2 2 THAP5 2 THAP8 2 3 SIMAP similar genes for THAP3 using alignment to 3 protein entries: THAP3_HUMAN (see all proteins ):THAP9 THAP1 THAP6
THAP3 for paralogs About GeneDecksing 1 Pseudogenes.org Pseudogene for THAP3 PGOHUM00000244826
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Genomic Variantsfor THAP3 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 1 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for THAP3 (6684926 - 6695646 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for THAP3: --
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing THAP3
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Disorders
/ Diseasesfor THAP3 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
THAP3 for disorders About MalaCards
THAP3 for disorders About GeneDecksing
OMIM gene information: 612532
OMIM disorders : --Human Genome Epidemiology (HuGE) Navigator: THAP3 (1 document)Export disorders for THAP3 gene to outside databases
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Publicationsfor THAP3 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for THAP3 gene integrated from 9 sources : (articles sorted by number of sources associating them with THAP3) Utopia : connect your pdf to the dynamic world of online information
The THAP-zinc finger protein THAP1 associates with co activator HCF-1 and O-GlcNAc transferase: a link between DYT6 and DYT3 dystonia s. (PubMed id 20200153) 1 , 2 Mazars R....Girard J.P. (2010) The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414) 1 , 2 Gregory S.G.... Bentley D.R. (2006) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 1 , 2 Gerhard D.S....Malek J. (2004) Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039) 1 , 2 Ota T.... Sugano S. (2004) The THAP domain: a novel protein motif with similarity to the DNA-binding domain of P element transposase. (PubMed id 12575992) 1 , 3 Roussigne M....Girard J.P. (2003) Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983) 1 Kim W....Gygi S.P. (2011) Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049) 1 OlA!h J....OvA!di J. (2011) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932) 1 Strausberg R.L....Marra M.A. (2002) Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548) 1 Bonaldo M.F.... Soares M.B. (1996)
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External Searches for THAP3 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing THAP3 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing THAP3 gene
(According to HUGE )
About This Section --
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Specialized Databases showing THAP3 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for THAP3 Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for THAP3 gene: Search GeneIP for patents involving THAP3 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor THAP3 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
Browse OriGene Antibodies OriGene shRNA RFP for THAP3 OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for THAP3 OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for THAP3 OriGene Protein Over-expression Lysate for THAP3 Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for THAP3 OriGene 3'-UTR Clone for THAP3 OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for THAP3 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for THAP3 Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for THAP3 OriGene Custom Protein Services for THAP3 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat THAP3 QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing THAP3 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat THAP3 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat THAP3 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat THAP3 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat THAP3
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THAP3 Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for THAP3
ThermoFisher Antibody for THAP3
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat THAP3
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Aliases for THAP3
Databases for THAP3
Disorders / Diseases for THAP3
Domains / Families for THAP3
Drugs / Compounds for THAP3
Expression for THAP3
Function for THAP3
Genomic Views for THAP3
Intellectual Property for THAP3
Orthologs for THAP3
Paralogs for THAP3
Pathways / Interactions for THAP3
Products for THAP3
Proteins for THAP3
Publications for THAP3
Search Box for THAP3
Summaries for THAP3
Transcripts for THAP3
Variants for THAP3
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