THAP2 Gene
protein-coding GIFtS: 45
GCID: GC12P072057
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THAP domain containing, apoptosis associated protein 2
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Aliases
for THAP2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| THAP Domain Containing, Apoptosis Associated Protein 21 2 | | DKFZP564I04221 | | THAP Domain-Containing Protein 22 |
Export aliases for THAP2 gene to outside databasesPrevious GC identifers: GC00U909479 GC12P070345 GC12P069106 |
Summaries
for THAP2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Gene Wiki entry for THAP2
|
Genomic Views
for THAP2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000012.11 NC_018923.1 NT_029419.12
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the THAP2 gene promoter:
TBP AML1a Nkx2-5 GATA-1 PPAR-alpha POU2F1 POU2F1a TFIID Pax-4a
Other transcription factors
Search SABiosciences Chromatin IP Primers for THAP2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat THAP2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 12q21.1 Ensembl cytogenetic band: 12q21.1 HGNC cytogenetic band: 12q21.1THAP2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 12 GeneLoc Exon Structure GeneLoc location for GC12P072057: view genomic region
(about GC identifiers)
Start:
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72,056,789 bp from pter |
End:
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72,074,419 bp from pter |
Size:
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17,631 bases |
Orientation:
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plus strand |
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Proteins
for THAP2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: THAP2_HUMAN, Q9H0W7 (See
protein sequence)Recommended Name: THAP domain-containing protein 2 Size: 228 amino acids; 26260 Da
1 PDB 3D structure from  and Proteopedia  for THAP2:2D8R (3D)
Secondary accessions: B2R8P3Explore the universe of human proteins at neXtProt for THAP2: NX_Q9H0W7
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9H0W7
THAP2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_113623.1
ENSEMBL proteins: ENSP00000310796 ENSP00000449826 ENSP00000448904 ENSP00000446986
Human Recombinant Protein Products for THAP2:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005730 | nucleolus |
IDA | -- |
THAP2 for ontologies About GeneDecksing
THAP2 Antibody Products:
Assay Products for THAP2: |
Protein
Domains /
Families
for THAP2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
THAP2 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9H0W7ProtoNet protein and cluster: Q9H0W7 UniProtKB/Swiss-Prot: THAP2_HUMAN, Q9H0W7Similarity: Contains 1 THAP-type zinc finger |
Function
for THAP2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003677 | DNA binding |
IEA | -- | | GO:0046872 | metal ion binding |
IEA | -- |
THAP2 for ontologies About GeneDecksing
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for THAP2 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for THAP2
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: THAP2 (NM_031435) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for THAP2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat THAP2 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for THAP2 |
|
Pathways & Interactions
for THAP2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for THAP2
STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)
3 Interacting proteins for THAP2 (Q9H0W72, 3 ENSP000003107964) via UniProtKB, MINT, STRING, and/or I2DAbout this table
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Drugs & Compounds
for THAP2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for THAP2
Search CenterWatch for drugs/clinical trials and news about THAP2
|
Transcripts
for THAP2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for THAP2 gene: NM_031435.3 Unigene Cluster for THAP2: THAP domain containing, apoptosis associated protein 2 Hs.245798 [show with all ESTs]Unigene Representative Sequence: NM_0314354 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000308086(uc001swq.3) ENST00000547843 ENST00000551488 ENST00000551238
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for THAP2 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for THAP2
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: THAP2 (NM_031435) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for THAP2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat THAP2 |
Additional cDNA sequence: AK313452.1 AL136607.1 BC008358.1 CR533485.1 5 DOTS entries: DT.100729720 DT.437910 DT.40293352 DT.97814562 DT.91706618 24/222 AceView cDNA sequences (see all 222): BU632826 AA437355 AA256905 AI984362 BC008358 AA419390 AA252597 BG677995 AI522043 AW139404 BM663344 AI540554 BM919026 CD364330 CD365674 BU680237 BM724799 AA970093 BU742594 AI141368 BQ020727 BX330945 CD742573 BP355686
GeneLoc Exon Structure
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Expression
for THAP2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| THAP2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTGGTGAAGT
About this image
See THAP2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for THAP2
SOURCE GeneReport for Unigene cluster: Hs.245798
SABiosciences Custom PCR Arrays for THAP2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for THAP2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat THAP2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat THAP2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat THAP2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for THAP2 |
Orthologs
for THAP2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for THAP2 gene from 1/7 species (see all 7) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
zebrafish
(Danio rerio) |
Actinopterygii |
zgc:1532436 |
zgc:153243 |
20(a) |
1 → many |
7(33959194-33963968) |
ENSEMBL Gene Tree for THAP2 (if available)
TreeFam Gene Tree for THAP2 (if available) |
Paralogs
for THAP2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for THAP2 gene
- THAP32 THAP12 ENSG000002580642 THAP52 THAP82
2 SIMAP similar genes for THAP2 using alignment to 4 protein entries: THAP2_HUMAN (see all proteins):DKFZP564I0422 THAP1
THAP2 for paralogs About GeneDecksing
|
Genomic Variants
for THAP2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 12 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for THAP2 (72056789 - 72074419 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for THAP2: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing THAP2 |
|
Disorders
/ Diseases
for THAP2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 THAP2 for disorders About MalaCards
THAP2 for disorders About GeneDecksing
OMIM gene information: 612531
OMIM disorders: --
Export disorders for THAP2 gene to outside databases
|
Publications
for THAP2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for THAP2 gene, integrated from 9 sources (see all 13):
(articles sorted by number of sources associating them with THAP2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The THAP domain: a novel protein motif with similarity to the DNA-binding domain of P element transposase. (PubMed id 12575992)1, 3 Roussigne M....Girard J.P. (2003)
- Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (2001)
- The genetic architecture of economic and political pre ferences. (PubMed id 22566634)1 Benjamin D.J....Visscher P.M. (2012)
- A data set of human endogenous protein ubiquitination sites. (PubMed id 20972266)1 Shi Y....Qin J. (2011)
- The LIFEdb database in 2006. (PubMed id 16381901)1 Mehrle A....Wiemann S. (2006)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. (PubMed id 15342556)1 Suzuki Y.... Sugano S. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
- From ORFeome to biology: a functional genomics pipeline. (PubMed id 15489336)1 Wiemann S....Poustka A. (2004)
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External Searches for THAP2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing THAP2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing THAP2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing THAP2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for THAP2 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for THAP2 gene:
Search GeneIP for patents involving THAP2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for THAP2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for THAP2 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for THAP2 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for THAP2 | | | OriGene Protein Over-expression Lysate for THAP2 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for THAP2 | | OriGene 3'-UTR Clone for THAP2 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for THAP2 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for THAP2 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for THAP2 | | OriGene Custom Protein Services for THAP2 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat THAP2 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing THAP2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat THAP2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat THAP2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat THAP2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat THAP2 |
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 |  |  |  | |
| | | | Search Tocris compounds for THAP2 |
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 | | | THAP2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for THAP2 |
|  |  |  |  | | | | ThermoFisher Antibody for THAP2 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat THAP2 |
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