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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

THAP2 Gene

protein-coding   GIFtS: 46
GCID: GC12P072057

THAP Domain Containing, Apoptosis Associated Protein 2

  Search for THAP2
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
THAP Domain Containing, Apoptosis Associated Protein 21 2
THAP Domain-Containing Protein 22

External Ids:    HGNC: 208541   Entrez Gene: 835912   Ensembl: ENSG000001734517   OMIM: 6125315   UniProtKB: Q9H0W73   

Export aliases for THAP2 gene to outside databases

Previous GC identifers: GC00U909479 GC12P070345 GC12P069106


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for THAP2 Gene: 
THAP2 (THAP domain containing, apoptosis associated protein 2) is a protein-coding gene. GO annotations related to this gene include DNA binding and metal ion binding. An important paralog of this gene is THAP3.

Gene Wiki entry for THAP2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NC_018923.2  NT_029419.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the THAP2 gene promoter:
         TBP   AML1a   Nkx2-5   GATA-1   PPAR-alpha   POU2F1   POU2F1a   TFIID   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTHAP2 promoter sequence
   Search SABiosciences Chromatin IP Primers for THAP2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat THAP2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q21.1   Ensembl cytogenetic band:  12q21.1   HGNC cytogenetic band: 12q21.1

THAP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
THAP2 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P072057:  view genomic region     (about GC identifiers)

Start:
72,056,789 bp from pter      End:
72,074,428 bp from pter
Size:
17,640 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: THAP2_HUMAN, Q9H0W7 (See protein sequence)
Recommended Name: THAP domain-containing protein 2  
Size: 228 amino acids; 26260 Da
1 PDB 3D structure from and Proteopedia for THAP2:
2D8R (3D)    
Secondary accessions: B2R8P3

Explore the universe of human proteins at neXtProt for THAP2: NX_Q9H0W7

Explore proteomics data for THAP2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9H0W7

  • THAP2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    THAP2 Protein Expression
    REFSEQ proteins: NP_113623.1  
    ENSEMBL proteins: 
     ENSP00000310796   ENSP00000449826   ENSP00000448904   ENSP00000446986  

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    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005730nucleolus IDA--

    THAP2 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    THAP: THAP (C2CH-type zinc finger) domain containing

    2 InterPro protein domains:
     IPR006612 Znf_C2CH
     IPR026521 THAP2

    Graphical View of Domain Structure for InterPro Entry Q9H0W7

    ProtoNet protein and cluster: Q9H0W7

    UniProtKB/Swiss-Prot: THAP2_HUMAN, Q9H0W7
    Similarity: Contains 1 THAP-type zinc finger


    THAP2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0046872metal ion binding IEA--
         
    THAP2 for ontologies           About GeneDecksing


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    SwitchGear 3'UTR luciferase reporter plasmidTHAP2 3' UTR sequence
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for THAP2

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    3 Interacting proteins for THAP2 (Q9H0W72, 3 ENSP000003107964) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PTPN12Q052092, 3MINT-61769 I2D: score=2 
    UBCENSP000003448184STRING: ENSP00000344818
    VANGL1ENSP000003108004STRING: ENSP00000310800
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for THAP2

    Search CenterWatch for drugs/clinical trials and news about THAP2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for THAP2 gene: 
    NM_031435.3  

    Unigene Cluster for THAP2:

    THAP domain containing, apoptosis associated protein 2
    Hs.245798  [show with all ESTs]
    Unigene Representative Sequence: NM_031435
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000308086(uc001swq.3) ENST00000547843 ENST00000551488 ENST00000551238

    miRNA
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    8/42 QIAGEN miScript miRNA Assays for microRNAs that regulate THAP2 (see all 42):
    hsa-miR-142-5p hsa-miR-3685 hsa-miR-607 hsa-miR-128 hsa-miR-570 hsa-miR-890 hsa-miR-3142 hsa-miR-183*
    SwitchGear 3'UTR luciferase reporter plasmidTHAP2 3' UTR sequence
    Inhib. RNA
    Products:
         
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    Additional mRNA sequence: 

    AK313452.1 AL136607.1 BC008358.1 CR533485.1 

    6 DOTS entries:

    DT.100729720  DT.437910  DT.40293352  DT.97814562  DT.442262  DT.91706618 

    24/222 AceView cDNA sequences (see all 222):

    BC008358 AI522043 BU680237 BP373217 CR603130 BM919026 AA512902 AW182598 
    AA129086 CD365674 BM852022 AI224500 BM728656 AA970093 CD742573 AA741145 
    AA770521 AA419390 BM728348 BX280526 AA252597 BU689370 AI015547 AA327600 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    THAP2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTGGTGAAGT
    THAP2 Expression
    About this image


    See THAP2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for THAP2

    SOURCE GeneReport for Unigene cluster: Hs.245798
        SABiosciences Custom PCR Arrays for THAP2
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for THAP2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of human and mouse.

    Orthologs for THAP2 gene from 1/6 species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Thap21 , 5 THAP domain containing, apoptosis associated protein 2 less1, 5 90.97(n)1
    89.25(a)1
      10 (63.51 cM)5
    668161  NM_025780.31  NP_080056.11 
     1153699665 


    ENSEMBL Gene Tree for THAP2 (if available)
    TreeFam Gene Tree for THAP2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for THAP2 gene
    THAP32  THAP12  ENSG000002580642  THAP52  THAP82  
    2 SIMAP similar genes for THAP2 using alignment to 4 protein entries:     THAP2_HUMAN (see all proteins):
    DKFZP564I0422    THAP1

    THAP2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/230 SNPs in THAP2 are shown (see all 230)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1424874691,2
    --72059754(+) CTAAAC/TTAAAC 1 -- int10--------
    rs171101411,2
    C,F,H--72059755(+) TAAACT/CAAACC 1 -- int19Minor allele frequency- C:0.03NA NS EA CSA WA 676
    rs1509313731,2
    --72059856(+) CAAGGA/CAAGTC 1 -- int10--------
    rs1900512511,2
    --72060016(+) CCAGTC/GTGGTG 1 -- int10--------
    rs1166240391,2
    F--72060047(+) CACTTC/TGAGAG 1 -- int11Minor allele frequency- T:0.01WA 118
    rs1816334671,2
    C--72060063(+) GGCGGC/GCTGAT 1 -- int10--------
    rs1408747171,2
    C--72060313(+) ACAAAA/CCAAAA 1 -- int10--------
    rs1855648331,2
    C--72060399(+) TCAGAA/CATTTA 1 -- int10--------
    rs1893078201,2
    --72060464(+) AACAAA/GGATTA 1 -- int10--------
    rs171101421,2
    C,F,H--72060466(+) CAAGGA/TTTAAT 1 -- int19Minor allele frequency- T:0.05NA NS EA CSA WA 682

    HapMap Linkage Disequilibrium report for THAP2 (72056789 - 72074428 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for THAP2:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv832451CNV Loss17160897

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    THAP2 for disorders           About MalaCards
    OMIM gene information: 612531    OMIM disorders: --


    THAP2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): THAP2

    Export disorders for THAP2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for THAP2 gene, integrated from 9 sources (see all 15):
    (articles sorted by number of sources associating them with THAP2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    2. The THAP domain: a novel protein motif with similarity to the DNA-binding domain of P element transposase. (PubMed id 12575992)1, 3 Roussigne M....Girard J.P. (2003)
    3. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (2001)
    4. The genetic architecture of economic and political pre ferences. (PubMed id 22566634)1 Benjamin D.J....Visscher P.M. (2012)
    5. Toward an understanding of the protein interaction net work of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (2011)
    6. A data set of human endogenous protein ubiquitination sites. (PubMed id 20972266)1 Shi Y....Qin J. (2011)
    7. The LIFEdb database in 2006. (PubMed id 16381901)1 Mehrle A....Wiemann S. (2006)
    8. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
    9. Functional proteomics mapping of a human signaling pathway. (PubMed id 15231748)1 Colland F....Gauthier J.M. (2004)
    10. Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. (PubMed id 15342556)1 Suzuki Y.... Sugano S. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 83591 HGNC: 20854 AceView: TMEM19andDKFZP564I0422 Ensembl:ENSG00000173451 euGenes: HUgn83591
    ECgene: THAP2 H-InvDB: THAP2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for THAP2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for THAP2 gene:
    Search GeneIP for patents involving THAP2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    (GIFtS: 73)
    transforming growth factor, beta 1
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