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Aliases for THAP2 Gene

Aliases for THAP2 Gene

  • THAP Domain Containing, Apoptosis Associated Protein 2 2 3

External Ids for THAP2 Gene

Previous GeneCards Identifiers for THAP2 Gene

  • GC00U909479
  • GC12P070345
  • GC12P072057
  • GC12P069106

Summaries for THAP2 Gene

GeneCards Summary for THAP2 Gene

THAP2 (THAP Domain Containing, Apoptosis Associated Protein 2) is a Protein Coding gene. An important paralog of this gene is THAP3.

Gene Wiki entry for THAP2 Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for THAP2 Gene

Genomics for THAP2 Gene

Regulatory Elements for THAP2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for THAP2 Gene

71,663,009 bp from pter
71,680,648 bp from pter
17,640 bases
Plus strand

Genomic View for THAP2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for THAP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for THAP2 Gene

Proteins for THAP2 Gene

  • Protein details for THAP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    THAP domain-containing protein 2
    Protein Accession:
    Secondary Accessions:
    • B2R8P3

    Protein attributes for THAP2 Gene

    228 amino acids
    Molecular mass:
    26260 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for THAP2 Gene

neXtProt entry for THAP2 Gene

Proteomics data for THAP2 Gene at MOPED

Post-translational modifications for THAP2 Gene

  • Ubiquitination at Lys143
  • Modification sites at PhosphoSitePlus

Other Protein References for THAP2 Gene

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for THAP2

No data available for DME Specific Peptides for THAP2 Gene

Domains for THAP2 Gene

Gene Families for THAP2 Gene

Protein Domains for THAP2 Gene


Suggested Antigen Peptide Sequences for THAP2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 THAP-type zinc finger.
  • Contains 1 THAP-type zinc finger.
genes like me logo Genes that share domains with THAP2: view

Function for THAP2 Gene

Gene Ontology (GO) - Molecular Function for THAP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with THAP2: view

Animal Model Products

miRNA for THAP2 Gene

miRTarBase miRNAs that target THAP2

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for THAP2

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targets and HOMER Transcription for THAP2 Gene

Localization for THAP2 Gene

Subcellular locations from

Jensen Localization Image for THAP2 Gene COMPARTMENTS Subcellular localization image for THAP2 gene
Compartment Confidence
nucleus 4
mitochondrion 2
cytosol 1
extracellular 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for THAP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005730 nucleolus IDA --
genes like me logo Genes that share ontologies with THAP2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for THAP2 Gene

Pathways for THAP2 Gene

SuperPathways for THAP2 Gene

No Data Available

Interacting Proteins for THAP2 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
Selected Interacting proteins: Q9H0W7-THAP2_HUMAN ENSP00000310796 for THAP2 Gene via MINT STRING I2D

Gene Ontology (GO) - Biological Process for THAP2 Gene


No data available for Pathways by source for THAP2 Gene

Transcripts for THAP2 Gene

mRNA/cDNA for THAP2 Gene

Unigene Clusters for THAP2 Gene

THAP domain containing, apoptosis associated protein 2:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for THAP2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for THAP2 Gene

No ASD Table

Relevant External Links for THAP2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for THAP2 Gene

mRNA expression in normal human tissues for THAP2 Gene

Protein differential expression in normal tissues for THAP2 Gene

This gene is overexpressed in Colon muscle (30.9) and Esophagus (6.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for THAP2 Gene

SOURCE GeneReport for Unigene cluster for THAP2 Gene Hs.245798

genes like me logo Genes that share expressions with THAP2: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Expression partners for THAP2 Gene

Orthologs for THAP2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for THAP2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia THAP2 35
  • 92.25 (n)
  • 93.42 (a)
THAP2 36
  • 93 (a)
(Canis familiaris)
Mammalia THAP2 35
  • 93.33 (n)
  • 93.49 (a)
THAP2 36
  • 93 (a)
(Mus musculus)
Mammalia Thap2 35
  • 90.97 (n)
  • 89.25 (a)
Thap2 16
Thap2 36
  • 88 (a)
(Pan troglodytes)
Mammalia THAP2 35
  • 99.71 (n)
  • 100 (a)
THAP2 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Thap2 35
  • 88.63 (n)
  • 89.25 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 76 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia thap2 35
  • 54.26 (n)
  • 43.6 (a)
Species with no ortholog for THAP2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for THAP2 Gene

Gene Tree for THAP2 (if available)
Gene Tree for THAP2 (if available)

Paralogs for THAP2 Gene

Paralogs for THAP2 Gene

(2) SIMAP similar genes for THAP2 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with THAP2: view

Variants for THAP2 Gene

Sequence variations from dbSNP and Humsavar for THAP2 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs941199 -- 71,676,279(-) TTGAT(A/G)AATAT intron-variant
rs1299291 -- 71,678,414(+) aaaat(A/T)aaaGT utr-variant-3-prime
rs1347218 -- 71,667,371(+) acttg(A/T)tgatg intron-variant
rs1971558 -- 71,669,994(-) TTTTT(C/T)TATTT intron-variant
rs1971559 -- 71,669,875(-) ggttc(A/G)agaga intron-variant

Structural Variations from Database of Genomic Variants (DGV) for THAP2 Gene

Variant ID Type Subtype PubMed ID
nsv832451 CNV Loss 17160897

Relevant External Links for THAP2 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for THAP2 Gene

Disorders for THAP2 Gene

Relevant External Links for THAP2

Genetic Association Database (GAD)

No disorders were found for THAP2 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for THAP2 Gene

Publications for THAP2 Gene

  1. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 3 4
  2. The THAP domain: a novel protein motif with similarity to the DNA-binding domain of P element transposase. (PMID: 12575992) Roussigne M. … Girard J.P. (Trends Biochem. Sci. 2003) 2 3
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. From ORFeome to biology: a functional genomics pipeline. (PMID: 15489336) Wiemann S. … Poustka A. (Genome Res. 2004) 3
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3

Products for THAP2 Gene

Sources for THAP2 Gene

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