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Aliases for THAP12 Gene

Aliases for THAP12 Gene

  • THAP Domain Containing 12 2 3 5
  • Death-Associated Protein 4 2 3 4
  • Protein-Kinase, Interferon-Inducible Double Stranded RNA Dependent Inhibitor, Repressor Of (P58 Repressor) 2 3
  • 58 KDa Interferon-Induced Protein Kinase-Interacting Protein 3 4
  • 52 KDa Repressor Of The Inhibitor Of The Protein Kinase 2 3
  • THAP Domain-Containing Protein 12 3 4
  • THAP Domain-Containing Protein 0 3 4
  • P58IPK-Interacting Protein 3 4
  • P58IPK-Regulatory Protein 2 3
  • P52rIPK 3 4
  • PRKRIR 3 4
  • THAP0 3 4
  • DAP4 3 4
  • Testicular Tissue Protein Li 133 3
  • Inhibitor Of Protein Kinase PKR 3

External Ids for THAP12 Gene

Previous HGNC Symbols for THAP12 Gene

  • PRKRIR

Summaries for THAP12 Gene

GeneCards Summary for THAP12 Gene

THAP12 (THAP Domain Containing 12) is a Protein Coding gene.

UniProtKB/Swiss-Prot for THAP12 Gene

  • Upstream regulator of interferon-induced serine/threonine protein kinase R (PKR). May block the PKR-inhibitory function of DNAJC3, resulting in restoration of kinase activity and suppression of cell growth.

Gene Wiki entry for THAP12 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for THAP12 Gene

Genomics for THAP12 Gene

Regulatory Elements for THAP12 Gene

Enhancers for THAP12 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11F076337 1.4 Ensembl ENCODE 10.9 +42.1 42140 3.3 CBX3 MAX ZFHX2 ZNF316 CBX5 NFE2 MAFK EGR2 CEBPZ CREB3 THAP12 LOC100506127 ENSG00000255135 LOC105369395
GH11F076046 0.8 VISTA 10.7 +332.7 332687 2.6 BCOR ESRRA CBX3 ZMYM3 GLI4 YY1 RARA CBX5 NFE2 CEBPZ ENSG00000255421 THAP12 PIR47539
GH11F075812 0.4 ENCODE 10.6 +565.8 565771 6.2 HDGF PKNOX1 ARNT MLX CREB3L1 WRNIP1 ARID4B SIN3A YBX1 DMAP1 TSKU SERPINH1 ENSG00000261578 LOC101928837 LRRC32 THAP12 RN7SL239P DGAT2 LOC105369391 ENSG00000255507
GH11F076860 0.5 ENCODE 10.1 -480.3 -480349 2.5 HDGF PKNOX1 CREB3L1 ZNF493 SIN3A GLI4 ZNF48 ZNF2 YY1 GLIS2 ACER3 RSF1 LOC100506127 THAP12 ENSG00000254988
GH11F076379 0.2 ENCODE 5.6 -0.2 -195 3.6 HDGF PKNOX1 MLX ARID4B SIN3A DMAP1 YY1 ZNF143 KLF13 DEK ENSG00000255363 ENSG00000255135 THAP12 LOC100506127
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around THAP12 on UCSC Golden Path with GeneCards custom track

Promoters for THAP12 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000565667 -129 2601 HDGF PKNOX1 MLX ARID4B SIN3A DMAP1 YY1 ZNF143 KLF13 DEK

Genomic Location for THAP12 Gene

Chromosome:
11
Start:
76,349,956 bp from pter
End:
76,380,971 bp from pter
Size:
31,016 bases
Orientation:
Minus strand

Genomic View for THAP12 Gene

Genes around THAP12 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
THAP12 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for THAP12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for THAP12 Gene

Proteins for THAP12 Gene

  • Protein details for THAP12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43422-P52K_HUMAN
    Recommended name:
    52 kDa repressor of the inhibitor of the protein kinase
    Protein Accession:
    O43422
    Secondary Accessions:
    • A8K728
    • Q17RY9
    • Q8WTW1
    • Q9Y3Z4

    Protein attributes for THAP12 Gene

    Size:
    761 amino acids
    Molecular mass:
    87704 Da
    Quaternary structure:
    • Interacts with DNAJC3, probably sequestring it.
    SequenceCaution:
    • Sequence=AAH21992.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAB43226.1; Type=Frameshift; Positions=471; Evidence={ECO:0000305};

    Alternative splice isoforms for THAP12 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for THAP12 Gene

Post-translational modifications for THAP12 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for THAP12 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for THAP12 Gene

Domains & Families for THAP12 Gene

Gene Families for THAP12 Gene

Protein Domains for THAP12 Gene

Graphical View of Domain Structure for InterPro Entry

O43422

UniProtKB/Swiss-Prot:

P52K_HUMAN :
  • Contains 1 THAP-type zinc finger.
Similarity:
  • Contains 1 THAP-type zinc finger.
genes like me logo Genes that share domains with THAP12: view

Function for THAP12 Gene

Molecular function for THAP12 Gene

UniProtKB/Swiss-Prot Function:
Upstream regulator of interferon-induced serine/threonine protein kinase R (PKR). May block the PKR-inhibitory function of DNAJC3, resulting in restoration of kinase activity and suppression of cell growth.

Gene Ontology (GO) - Molecular Function for THAP12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IBA --
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IBA --
GO:0005515 protein binding IPI 25416956
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with THAP12: view
genes like me logo Genes that share phenotypes with THAP12: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for THAP12 Gene

Localization for THAP12 Gene

Gene Ontology (GO) - Cellular Components for THAP12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IBA --
GO:0005737 cytoplasm IBA --
genes like me logo Genes that share ontologies with THAP12: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from COMPARTMENTS for THAP12 Gene

Pathways & Interactions for THAP12 Gene

SuperPathways for THAP12 Gene

No Data Available

Gene Ontology (GO) - Biological Process for THAP12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006357 regulation of transcription from RNA polymerase II promoter IEA --
GO:0006950 response to stress TAS 9447982
GO:0007165 signal transduction TAS 9447982
GO:0008285 negative regulation of cell proliferation TAS 9447982
genes like me logo Genes that share ontologies with THAP12: view

No data available for Pathways by source and SIGNOR curated interactions for THAP12 Gene

Transcripts for THAP12 Gene

Unigene Clusters for THAP12 Gene

Protein-kinase, interferon-inducible double stranded RNA dependent inhibitor, repressor of (P58 repressor):
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for THAP12 Gene

No ASD Table

Relevant External Links for THAP12 Gene

GeneLoc Exon Structure for
THAP12
ECgene alternative splicing isoforms for
THAP12

Expression for THAP12 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

NURSA nuclear receptor signaling pathways regulating expression of THAP12 Gene:

THAP12

SOURCE GeneReport for Unigene cluster for THAP12 Gene:

Hs.503315
genes like me logo Genes that share expression patterns with THAP12: view

Primer Products

No data available for mRNA expression in normal human tissues , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for THAP12 Gene

Orthologs for THAP12 Gene

This gene was present in the common ancestor of chordates.

Orthologs for THAP12 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PRKRIR 34 35
  • 99.94 (n)
dog
(Canis familiaris)
Mammalia PRKRIR 34 35
  • 92.25 (n)
cow
(Bos Taurus)
Mammalia PRKRIR 34 35
  • 92.2 (n)
oppossum
(Monodelphis domestica)
Mammalia PRKRIR 35
  • 89 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Prkrir 34
  • 88.55 (n)
mouse
(Mus musculus)
Mammalia Prkrir 34 16 35
  • 88.51 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia PRKRIR 35
  • 73 (a)
OneToOne
chicken
(Gallus gallus)
Aves PRKRIR 34 35
  • 78.67 (n)
lizard
(Anolis carolinensis)
Reptilia PRKRIR 35
  • 80 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia prkrir 34
  • 67.26 (n)
MGC75860 34
zebrafish
(Danio rerio)
Actinopterygii prkrirb 34 35
  • 61.4 (n)
prkrira 35
  • 52 (a)
OneToMany
PRKRIR (3 of 3) 35
  • 9 (a)
OneToMany
Dr.2925 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.12467 34
Species where no ortholog for THAP12 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for THAP12 Gene

ENSEMBL:
Gene Tree for THAP12 (if available)
TreeFam:
Gene Tree for THAP12 (if available)

Paralogs for THAP12 Gene

No data available for Paralogs for THAP12 Gene

Variants for THAP12 Gene

Sequence variations from dbSNP and Humsavar for THAP12 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs10736804 -- 76,369,022(+) CATTC(A/G)AAATA intron-variant
rs10793155 -- 76,354,148(+) TAAGG(C/T)AGAAG intron-variant
rs10793156 -- 76,372,527(+) gcctc(A/G)gcctc intron-variant
rs10899211 -- 76,378,724(+) CTCAC(A/G)TCTTG intron-variant
rs111752008 -- 76,366,577(+) TCGGG(A/G)GGCTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for THAP12 Gene

Variant ID Type Subtype PubMed ID
esv2459110 CNV insertion 19546169
esv3305038 CNV mobile element insertion 20981092
esv3397613 CNV insertion 20981092
nsv521451 CNV loss 19592680
nsv975204 CNV duplication 23825009

Variation tolerance for THAP12 Gene

Residual Variation Intolerance Score: 29.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.46; 54.91% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for THAP12 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
THAP12

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for THAP12 Gene

Disorders for THAP12 Gene

Relevant External Links for THAP12

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
THAP12
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
THAP12

No disorders were found for THAP12 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for THAP12 Gene

Publications for THAP12 Gene

  1. Regulation of interferon-induced protein kinase PKR: modulation of P58IPK inhibitory function by a novel protein, P52rIPK. (PMID: 9447982) Gale M.J. Jr. … Katze M.G. (Mol. Cell. Biol. 1998) 2 3 4 64
  2. The THAP domain of THAP1 is a large C2CH module with zinc-dependent sequence-specific DNA-binding activity. (PMID: 15863623) Clouaire T. … Girard J.-P. (Proc. Natl. Acad. Sci. U.S.A. 2005) 2 3 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64

Products for THAP12 Gene

Sources for THAP12 Gene

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