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Aliases for THAP12 Gene

Aliases for THAP12 Gene

  • THAP Domain Containing 12 2 3
  • Protein-Kinase, Interferon-Inducible Double Stranded RNA Dependent Inhibitor, Repressor Of (P58 Repressor) 2 3 5
  • Death-Associated Protein 4 2 3 4
  • PRKRIR 3 4 5
  • 58 KDa Interferon-Induced Protein Kinase-Interacting Protein 3 4
  • THAP Domain-Containing Protein 0 3 4
  • P58IPK-Interacting Protein 3 4
  • P58IPK-Regulatory Protein 2 3
  • P52rIPK 3 4
  • THAP0 3 4
  • DAP4 3 4
  • 52 KDa Repressor Of The Inhibitor Of The Protein Kinase 2
  • Testicular Tissue Protein Li 133 3
  • Inhibitor Of Protein Kinase PKR 3

External Ids for THAP12 Gene

Previous HGNC Symbols for THAP12 Gene

  • PRKRIR

Summaries for THAP12 Gene

GeneCards Summary for THAP12 Gene

THAP12 (THAP Domain Containing 12) is a Protein Coding gene.

UniProtKB/Swiss-Prot for THAP12 Gene

  • Upstream regulator of interferon-induced serine/threonine protein kinase R (PKR). May block the PKR-inhibitory function of P58IPK, resulting in restoration of kinase activity and suppression of cell growth.

Gene Wiki entry for THAP12 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for THAP12 Gene

Genomics for THAP12 Gene

Regulatory Elements for THAP12 Gene

Enhancers for THAP12 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around THAP12 on UCSC Golden Path with GeneCards custom track

Promoters for THAP12 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around THAP12 on UCSC Golden Path with GeneCards custom track

Genomic Location for THAP12 Gene

Chromosome:
11
Start:
76,349,956 bp from pter
End:
76,380,971 bp from pter
Size:
31,016 bases
Orientation:
Minus strand

Genomic View for THAP12 Gene

Genes around THAP12 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
THAP12 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for THAP12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for THAP12 Gene

Proteins for THAP12 Gene

  • Protein details for THAP12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43422-P52K_HUMAN
    Recommended name:
    52 kDa repressor of the inhibitor of the protein kinase
    Protein Accession:
    O43422
    Secondary Accessions:
    • A8K728
    • Q17RY9
    • Q8WTW1
    • Q9Y3Z4

    Protein attributes for THAP12 Gene

    Size:
    761 amino acids
    Molecular mass:
    87704 Da
    Quaternary structure:
    • Interacts with P58IPK, probably sequestring it.
    SequenceCaution:
    • Sequence=AAH21992.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAB43226.1; Type=Frameshift; Positions=471; Evidence={ECO:0000305};

    Alternative splice isoforms for THAP12 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for THAP12 Gene

Proteomics data for THAP12 Gene at MOPED

Post-translational modifications for THAP12 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for THAP12 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for THAP12 Gene

Domains & Families for THAP12 Gene

Gene Families for THAP12 Gene

Protein Domains for THAP12 Gene

Graphical View of Domain Structure for InterPro Entry

O43422

UniProtKB/Swiss-Prot:

P52K_HUMAN :
  • Contains 1 THAP-type zinc finger.
Similarity:
  • Contains 1 THAP-type zinc finger.
genes like me logo Genes that share domains with THAP12: view

Function for THAP12 Gene

Molecular function for THAP12 Gene

UniProtKB/Swiss-Prot Function:
Upstream regulator of interferon-induced serine/threonine protein kinase R (PKR). May block the PKR-inhibitory function of P58IPK, resulting in restoration of kinase activity and suppression of cell growth.

Gene Ontology (GO) - Molecular Function for THAP12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IBA --
GO:0003677 DNA binding IEA,IBA --
genes like me logo Genes that share ontologies with THAP12: view
genes like me logo Genes that share phenotypes with THAP12: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for THAP12 Gene

Localization for THAP12 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for THAP12 Gene

Pathways & Interactions for THAP12 Gene

SuperPathways for THAP12 Gene

No Data Available

Gene Ontology (GO) - Biological Process for THAP12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006950 response to stress TAS 9447982
genes like me logo Genes that share ontologies with THAP12: view

No data available for Pathways by source and SIGNOR curated interactions for THAP12 Gene

Drugs & Compounds for THAP12 Gene

No Compound Related Data Available

Transcripts for THAP12 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for THAP12 Gene

No ASD Table

Relevant External Links for THAP12 Gene

GeneLoc Exon Structure for
THAP12
ECgene alternative splicing isoforms for
THAP12

Expression for THAP12 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

genes like me logo Genes that share expression patterns with THAP12: view

No data available for mRNA expression in normal human tissues , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for THAP12 Gene

Orthologs for THAP12 Gene

This gene was present in the common ancestor of chordates.

Orthologs for THAP12 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PRKRIR 35
  • 92.2 (n)
  • 96.84 (a)
PRKRIR 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PRKRIR 35
  • 92.25 (n)
  • 96.71 (a)
PRKRIR 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Prkrir 35
  • 88.51 (n)
  • 95.24 (a)
Prkrir 16
Prkrir 36
  • 95 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PRKRIR 35
  • 99.94 (n)
  • 100 (a)
PRKRIR 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Prkrir 35
  • 88.55 (n)
  • 96.3 (a)
oppossum
(Monodelphis domestica)
Mammalia PRKRIR 36
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PRKRIR 36
  • 73 (a)
OneToOne
chicken
(Gallus gallus)
Aves PRKRIR 35
  • 78.67 (n)
  • 86.07 (a)
PRKRIR 36
  • 72 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PRKRIR 36
  • 80 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC75860 35
prkrir 35
  • 67.26 (n)
  • 71.6 (a)
zebrafish
(Danio rerio)
Actinopterygii Dr.2925 35
prkrirb 35
  • 61.4 (n)
  • 57.97 (a)
PRKRIR (3 of 3) 36
  • 9 (a)
OneToMany
prkrira 36
  • 52 (a)
OneToMany
prkrirb 36
  • 56 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.12467 35
Species with no ortholog for THAP12:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for THAP12 Gene

ENSEMBL:
Gene Tree for THAP12 (if available)
TreeFam:
Gene Tree for THAP12 (if available)

Paralogs for THAP12 Gene

genes like me logo Genes that share paralogs with THAP12: view

No data available for Paralogs for THAP12 Gene

Variants for THAP12 Gene

Sequence variations from dbSNP and Humsavar for THAP12 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs2156713 -- 76,355,706(+) ACTGA(C/T)CTCTA intron-variant
rs2226895 -- 76,360,090(+) AACAG(C/T)TTCTC intron-variant
rs7127175 -- 76,363,149(+) AAAAA(A/T)AATAA intron-variant
rs11600953 -- 76,371,298(+) CCTGC(A/G)CTGTT intron-variant
rs11603888 -- 76,376,467(+) AAAGC(A/G)TCCAG intron-variant

Variation tolerance for THAP12 Gene

Residual Variation Intolerance Score: 29.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.46; 54.91% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for THAP12 Gene

Disorders for THAP12 Gene

Relevant External Links for THAP12

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
THAP12
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
THAP12

No disorders were found for THAP12 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for THAP12 Gene

Publications for THAP12 Gene

  1. Regulation of interferon-induced protein kinase PKR: modulation of P58IPK inhibitory function by a novel protein, P52rIPK. (PMID: 9447982) Gale M.J. Jr. … Katze M.G. (Mol. Cell. Biol. 1998) 2 3 4 67
  2. The THAP domain of THAP1 is a large C2CH module with zinc-dependent sequence-specific DNA-binding activity. (PMID: 15863623) Clouaire T. … Girard J.-P. (Proc. Natl. Acad. Sci. U.S.A. 2005) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  5. TRIM65 regulates microRNA activity by ubiquitination of TNRC6. (PMID: 24778252) Li S. … Dorf M.E. (Proc. Natl. Acad. Sci. U.S.A. 2014) 3

Products for THAP12 Gene

Sources for THAP12 Gene

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